KH
MCID: KPS002
MIFTS: 27

Kaposiform Hemangioendothelioma (KH) malady

Cardiovascular diseases, Fetal diseases, Cancer diseases categories

Summaries for Kaposiform Hemangioendothelioma

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MalaCards: Kaposiform Hemangioendothelioma, also known as congenital cutaneous multifocal kaposiform hemangioendothelioma, is related to hemangioma and lymphedema. An important gene associated with Kaposiform Hemangioendothelioma is FLT4 (fms-related tyrosine kinase 4), and among its related pathways is Lymphocyte Signaling. The compounds estrogen and vegf have been mentioned in the context of this disorder. Related mouse phenotype immune system.

Aliases & Classifications for Kaposiform Hemangioendothelioma

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42NIH Rare Diseases, 48Orphanet, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases, Cancer diseases
Anatomical: Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

48
kaposiform hemangioendothelioma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

kaposiform hemangioendothelioma 42 48 60
congenital cutaneous multifocal kaposiform hemangioendothelioma 42
kaposiform hemangio-endothelioma 42
khe 42
kh 42


External Ids:

ICD10 via Orphanet26 D18.0
SNOMED-CT via Orphanet57 403983000
UMLS via Orphanet61 C1367420
MESH via Orphanet35 C537007

Related Diseases for Kaposiform Hemangioendothelioma

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17GeneCards, 18GeneDecks
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Diseases related to Kaposiform Hemangioendothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1hemangioma30.6FLI1, FLT4, CD34, IFNA2, PROX1
2lymphedema30.2FLT4, PROX1
3lymphangioma30.2FLT4, PROX1, CD34
4sarcoma30.2FLI1, FLT4, CD34
5acute leukemia29.9FLT4, CD34
6mediastinitis10.4
7fragile x syndrome10.2
8hereditary lymphedema10.2
9tonsillitis10.2
10adult syndrome10.2
11cervicitis10.2
12laryngitis10.2
13pericardial effusion10.2
14hemophilia10.2
15tufted angioma10.2
16hemangioma thrombocytopenia syndrome10.2
17lymphangiosarcoma10.0PROX1
18malignant mesothelioma10.0FLT4
19pancreatic cancer10.0FLT4
20capillary hemangioma10.0CD34
21kaposi's sarcoma10.0CD34
22myeloid leukemia10.0CD34
23hemangiopericytoma10.0CD34
24myelodysplastic syndromes10.0CD34
25myelofibrosis10.0IFNA2
26mycosis fungoides10.0IFNA2
27papilloma10.0FLT4, IFNA2
28polycythemia10.0CD34
29pyogenic granuloma10.0FLT4, CD34
30hepatocellular carcinoma10.0CD34, IFNA2
31epithelioid hemangioendothelioma10.0CD34, FLT4, IFNA2
32liposarcoma10.0FLI1, CD34
33colorectal cancer10.0FLT4, IFNA2, CD34
34angiosarcoma10.0FLT4, FLI1, CD34
35thrombocytopenia10.0CD34, FLI1, IFNA2
36synovial sarcoma10.0CD34, FLI1
37burkitt's lymphoma10.0FLT4, FLI1, CD34
38adenocarcinoma10.0CD34, FLI1, FLT4
39prostate cancer10.0FLI1, FLT4, CD34
40hemangioendothelioma10.0IFNA2, CD34, FLI1, FLT4
41vascular cancer10.0FLI1, FLT4, CD34, IFNA2
42melanoma10.0FLT4, IFNA2, FLI1, CD34
43breast cancer10.0CD34, FLI1, FLT4, PROX1
44macroglobulinemia9.9
45presbyopia9.9
46neuronitis9.9
47muscular atrophy9.9
48amyloidosis9.9
49blood protein disease9.9
50brain stem infarction9.9

Graphical network of the top 20 diseases related to Kaposiform Hemangioendothelioma:



Diseases related to kaposiform hemangioendothelioma

Clinical Features for Kaposiform Hemangioendothelioma

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Drugs & Therapeutics for Kaposiform Hemangioendothelioma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Kaposiform Hemangioendothelioma

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Anatomical Context for Kaposiform Hemangioendothelioma

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Animal Models for Kaposiform Hemangioendothelioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Kaposiform Hemangioendothelioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1CD34, PROX1, FLT4, FLI1

Publications for Kaposiform Hemangioendothelioma

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Genetic Variations for Kaposiform Hemangioendothelioma

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Expression for genes affiliated with Kaposiform Hemangioendothelioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Kaposiform Hemangioendothelioma

Search GEO for disease gene expression data for Kaposiform Hemangioendothelioma.

Pathways for genes affiliated with Kaposiform Hemangioendothelioma

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4Cell Signaling Technology
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Pathways related to Kaposiform Hemangioendothelioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CD34, FLI1

Compounds for genes affiliated with Kaposiform Hemangioendothelioma

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44Novoseek
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Compounds related to Kaposiform Hemangioendothelioma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1estrogen448.7CD34, FLT4, IFNA2
2vegf447.8CD34, PROX1, FLT4, IFNA2

GO Terms for genes affiliated with Kaposiform Hemangioendothelioma

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16Gene Ontology
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Biological processes related to Kaposiform Hemangioendothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lymphangiogenesisGO:0019469.4PROX1, FLT4
2positive regulation of endothelial cell migrationGO:0105959.3PROX1, FLT4
3negative regulation of gene expressionGO:0106299.1CD34, IFNA2
4positive regulation of endothelial cell proliferationGO:0019389.1PROX1, FLT4

Products for genes affiliated with Kaposiform Hemangioendothelioma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Kaposiform Hemangioendothelioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet