MCD
MCID: KPS001
MIFTS: 87

Kaposi's Sarcoma (MCD) malady

Cancer diseases, Infectious diseases, Rare diseases categories
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Summaries for Kaposi's Sarcoma

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MedlinePlus:33 Kaposi's sarcoma is a cancer that causes patches of abnormal tissue to grow under the skin, in the lining of the mouth, nose, and throat or in other organs. the patches are usually red or purple and are made of cancer cells and blood cells. the red and purple patches often cause no symptoms, though they may be painful. if the cancer spreads to the digestive tract or lungs, bleeding can result. lung tumors can make breathing hard. before the hiv/aids epidemic, ks usually developed slowly. in hiv/aids patients, though, the disease moves quickly. treatment depends on where the lesions are and how bad they are. treatment for hiv itself can shrink the lesions. however, treating ks does not improve survival from hiv/aids itself. nih: national cancer institute

MalaCards based summary: Kaposi's Sarcoma, also known as kaposi sarcoma, is related to sarcoma and acquired immunodeficiency syndrome, and has symptoms including hepatomegaly/liver enlargement (excluding storage disease), splenomegaly and acute abdominal pain/colic. An important gene associated with Kaposi's Sarcoma is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Signaling by VEGF and Signaling by FGFR3 mutants. The drugs etoposide and etoposide phosphate and the compounds pegasys and azd 2171 have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and lymph node, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:8 A connective tissue cancer that derives from lymphatic endothelium, and derives from spindle cells, results in formation of vascular channels that fill with blood cells, has material basis in human herpesvirus 8 (hhv8).

Description from OMIM:46 148000

Aliases & Classifications for Kaposi's Sarcoma

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Sources:
8Disease Ontology, 48Orphanet, 33MedlinePlus, 46OMIM, 44Novoseek, 62UMLS, 9diseasecard, 10DISEASES, 57SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 63UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Kaposi's Sarcoma, Aliases & Descriptions:

Name: Kaposi's Sarcoma 8 48 33
Kaposi Sarcoma 8 46 44 62
Kaposi's Sarcoma of Gastrointestinal Sites 8 62
Multicentric Giant Lymph Node Hyperplasia 48 62
Angiofollicular Ganglionic Hyperplasia 48 62
Kaposi's Sarcoma of the Gallbladder 8 62
Angiofollicular Lymph Hyperplasia 48 62
Kaposi's Sarcoma of Soft Tissues 8 62
Kaposi's Sarcoma of the Prostate 8 62
Kaposi's Sarcoma of Conjunctiva 8 62
Kaposi's Sarcoma of Lymph Nodes 8 62
Kaposi's Sarcoma of Soft Tissue 8 62
Kaposi's Sarcoma of Esophagus 8 62
Gallbladder Kaposi's Sarcoma 8 62
Kaposi's Sarcoma of Cornea 8 62
Pulmonary Kaposi's Sarcoma 8 62
Kaposi's Sarcoma of Palate 8 62
Kaposi's Sarcoma of Penis 8 62
Kaposi's Sarcoma of Heart 8 62
Gastric Kaposi's Sarcoma 8 62
Cardiac Kaposi's Sarcoma 8 62
Kaposi's Sarcoma of Skin 8 62
Kaposi's Sarcoma of Lung 8 62
Kaposi's Sarcoma of Anus 8 62
 
Castleman Disease 48 62
Kaposis Sarcoma 10 62
Mcd 48 62
Kaposi Sarcoma of the Central Nervous System 62
Kaposi's Sarcoma of Central Nervous System 8
Central Nervous System Kaposi's Sarcoma 8
Lymphadenopathic Kaposi's Sarcoma 8
Multi-Centric Castleman's Disease 62
Kaposi Sarcoma, Susceptibility to 9
Multicentric Castleman Disease 48
Conjunctival Kaposi's Sarcoma 8
Soft Tissue Kaposi's Sarcoma 8
Intestinal Kaposi's Sarcoma 8
Kaposi's Sarcoma of the Cns 8
Esophageal Kaposi's Sarcoma 8
Lymph Node Kaposi's Sarcoma 8
Cutaneous Kaposi's Sarcoma 8
Prostate Kaposi's Sarcoma 8
Corneal Kaposi's Sarcoma 8
Palate Kaposi's Sarcoma 8
Kaposi's Sarcoma, Lung 8
Penis Kaposi's Sarcoma 8
Kaposi's Sarcoma, Skin 8
Anal Kaposi's Sarcoma 8


Classifications:



Characteristics (Orphanet epidemiological data):

48
angiofollicular ganglionic hyperplasia:
Inheritance: Sporadic; Age of onset: Variable
kaposi's sarcoma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


External Ids:

Disease Ontology8 DOID:8632
ICD9CM27 176, 176.9
NCIt39 C9087
OMIM46 148000
UMLS via Orphanet63 C0017531, C2931179, C0036220 C1334815, more
MESH via Orphanet35 C536362, D005871, D012514 C537372, more
ICD10 via Orphanet26 D36.0, C46.3, C46.7 C46.8, C46.9, C46.0, C46.1, C46.2, more

Related Diseases for Kaposi's Sarcoma

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Diseases related to Kaposi's Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 202)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma32.5CD34, TAT, FLT4, OSM
2acquired immunodeficiency syndrome31.6IFNA1, IL6, TAT
3castleman's disease31.4IL6, IL6R
4pyogenic granuloma31.1FLT4, LYVE1, CD34
5lymphangioma31.0CD34, LYVE1, FLT4
6angiosarcoma31.0CD34, FLT4
7leukopenia30.9IL6, IFNA2, IFNA1
8hemangioma30.8VEGFA, FLT4, LYVE1, IFNA2, CD34, FGF4
9hepatitis c30.8IFNA1, IFNA2, IL6R
10poems syndrome30.7VEGFA, IL6
11hepatitis30.7IFNA1, IFNA2, HGF, TAT
12arthritis30.7OSM, IL6
13meningioma30.7CD34
14lymphedema30.7LYVE1, FLT4
15deficiency anemia30.7IFNA1, IFNA2, IL6, TAT, CD34
16rheumatoid arthritis30.6IL6R, IL6, IL6ST, OSM, VEGFA
17plasmacytoma30.5OSM, IL6ST, IL6, IL6R
18leukemia30.3OSM, FLT4, IFNA1, IFNA2, IL6ST, IL6
19myeloma29.8VEGFA, OSM, IFNA1, IFNA2, IL6ST, IL6
20classic kaposi sarcoma11.0
21endemic kaposi sarcoma10.6
22primary effusion lymphoma10.6
23polyarteritis nodosa10.6IFNA2
24crohn disease-associated growth failure10.6IL6
25lymphomatoid granulomatosis10.6IFNA2
26panuveitis10.6IFNA2
27capillary hemangioma10.6CD34
28angiofollicular lymph hyperplasia10.6
29central retinal vein occlusion10.5VEGFA
30fibrous histiocytoma10.5CD34
31cryoglobulinemic vasculitis10.5IFNA2, IFNA1
32hydrocele10.5FLT4
33endotheliitis10.5
34diabetic macular edema10.5VEGFA
35cryoglobulinemia10.5IFNA1, IFNA2
36papilloma10.5FLT4, IFNA2
37hepatitis d10.5IFNA1, IFNA2
38factor vii deficiency10.5VEGFA, IFNA1, IFNA2
39thrombocytosis10.5IL6, IFNA2, IFNA1
40epithelioid hemangioendothelioma10.5FLT4, IFNA2, CD34
41hemangioendothelioma10.5FLT4, IFNA2, CD34
42kidney cancer10.5IFNA2, IFNA1, VEGFA
43vascular cancer10.5VEGFA, FLT4
44neutropenia10.5IFNA1, IFNA2, CD34
45ovarian hyperstimulation syndrome10.5VEGFA, IL6R
46thrombocytopenia10.4IFNA1, IFNA2, IL6, CD34
47choriocarcinoma10.4OSM, IL6ST, IL6R, FGF4
48hypothyroidism10.4IFNA1, IFNA2
49coronary artery anomaly10.4CYSLTR2, FGF4, FGF5
50bladder carcinoma10.4FGF3, FGF4, IFNA2, VEGFA

Graphical network of the top 20 diseases related to Kaposi's Sarcoma:



Diseases related to kaposi's sarcoma

Symptoms for Kaposi's Sarcoma

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Symptoms by clinical synopsis from OMIM:

148000

Clinical features from OMIM:

148000

Symptoms:

48 (show all 35)
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • acute abdominal pain/colic
  • thoracic/chest pain
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • gynecomastia/breast/mammary gland enlargement/hyperplasia
  • tapered fingers
  • cutaneous rash
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • cutaneous edema
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • purpura/petichiae
  • capillary hemangioma/nevus/naevus flammeus/port-wine stain
  • hirsutism/hypertrichosis/increased body hair
  • ascitis
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • lymphadenopathy/polyadenopathies
  • lymphedema
  • renal glomerular defect/glomerulopathy
  • interstitial nephropathy
  • renal failure
  • proteinuria
  • impotence/painful erection/priapism/erection troubles
  • hypothyroidy
  • diabetes mellitus
  • precocious menopause/secondary amenorrhea
  • peripheral neuropathy
  • arthritis/synovitis/synovial proliferation
  • monoclonal immunoglobulins/gammapathy/dysglobulinemia
  • anaemia
  • platelet disorders/thrombopathies
  • thrombocytopenia/thrombopenia
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • asthenia/fatigue/weakness

HPO human phenotypes related to Kaposi's Sarcoma:

(show all 33)
id Description Frequency HPO Source Accession
1 splenomegaly hallmark (90%) HP:0001744
2 hepatomegaly hallmark (90%) HP:0002240
3 abdominal pain typical (50%) HP:0002027
4 chest pain typical (50%) HP:0100749
5 renal insufficiency occasional (7.5%) HP:0000083
6 proteinuria occasional (7.5%) HP:0000093
7 gynecomastia occasional (7.5%) HP:0000771
8 diabetes mellitus occasional (7.5%) HP:0000819
9 hypothyroidism occasional (7.5%) HP:0000821
10 secondary amenorrhea occasional (7.5%) HP:0000869
11 skin rash occasional (7.5%) HP:0000988
12 hypertrichosis occasional (7.5%) HP:0000998
13 lymphedema occasional (7.5%) HP:0001004
14 tapered finger occasional (7.5%) HP:0001182
15 arthritis occasional (7.5%) HP:0001369
16 ascites occasional (7.5%) HP:0001541
17 weight loss occasional (7.5%) HP:0001824
18 thrombocytopenia occasional (7.5%) HP:0001873
19 anemia occasional (7.5%) HP:0001903
20 subcutaneous hemorrhage occasional (7.5%) HP:0001933
21 abnormality of the pleura occasional (7.5%) HP:0002103
22 lymphadenopathy occasional (7.5%) HP:0002716
23 abnormality of temperature regulation occasional (7.5%) HP:0004370
24 generalized hyperpigmentation occasional (7.5%) HP:0007440
25 abnormal blistering of the skin occasional (7.5%) HP:0008066
26 peripheral neuropathy occasional (7.5%) HP:0009830
27 abnormal immunoglobulin level occasional (7.5%) HP:0010701
28 erectile abnormalities occasional (7.5%) HP:0100639
29 glomerulopathy occasional (7.5%) HP:0100820
30 autosomal dominant inheritance HP:0000006
31 edema HP:0000969
32 hypermelanotic macule HP:0001034
33 neoplasm HP:0002664

Drugs & Therapeutics for Kaposi's Sarcoma

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Genetic Tests for Kaposi's Sarcoma

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Anatomical Context for Kaposi's Sarcoma

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MalaCards organs/tissues related to Kaposi's Sarcoma:

32
Lung, Skin, Lymph node, Endothelial, Prostate, Heart, Liver, Breast, T cells, B cells, Bone, Colon, Monocytes, Neutrophil, Bone marrow, Brain, Kidney, Myeloid, Tongue, Spleen, Nk cells

Animal Models for Kaposi's Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Kaposi's Sarcoma:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.8VEGFA, IL6ST, IL6, IL6R, CD34, SLC7A11
2MP:00053709.7VEGFA, FLT4, IL6ST, IL6, IL6R, HGF
3MP:00053859.4CYSLTR2, VEGFA, FLT4, LYVE1, STIM1, IL6ST
4MP:00053789.4FLT4, STIM1, IL6ST, IL6, IL6R, HGF
5MP:00028739.4VEGFA, FLT4, CCR8, IL6ST, IL6R, FGF4
6MP:00053909.3VEGFA, STIM1, IL6ST, IL6, FGF4, FGF3
7MP:00053979.3VEGFA, LYVE1, STIM1, IL6ST, IL6, IL6R
8MP:00053849.3VEGFA, LYVE1, STIM1, IL6ST, IL6, IL6R
9MP:00107719.1FGF5, CYSLTR2, VEGFA, OSM, FLT4, STIM1
10MP:00107689.1VEGFA, FLT4, STIM1, CCNK, IL6ST, IL6
11MP:00053769.0CYSLTR2, VEGFA, FLT4, STIM1, IL6ST, IL6
12MP:00053878.9CYSLTR2, VEGFA, FLT4, LYVE1, STIM1, CCR8

Publications for Kaposi's Sarcoma

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Articles related to Kaposi's Sarcoma:

(show top 50)    (show all 1075)
idTitleAuthorsYear
1
Kaposi's Sarcoma-Associated Herpesvirus-Encoded RTA Impairs Innate Immunity via Ubiquitin-mediated Degradation of MyD88. (25320320)
2014
2
Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation. (25299066)
2014
3
Mathematical Modeling of the HIV/Kaposi's Sarcoma Coinfection Dynamics in Areas of High HIV Prevalence. (24348744)
2013
4
Epigenetic diversity of Kaposi's sarcoma-associated herpesvirus. (23361465)
2013
5
Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins down regulate both DC-SIGN and DC-SIGNR. (23460925)
2013
6
The viral interferon regulatory factors of kaposi's sarcoma-associated herpesvirus differ in their inhibition of interferon activation mediated by toll-like receptor 3. (23115281)
2013
7
Bilateral auricular classic Kaposi's sarcoma. (24014559)
2013
8
Myasthenia gravis developing in an HIV-negative patient with Kaposi's sarcoma. (23010878)
2013
9
Association of Kaposi's sarcoma-associated herpesvirus (KSHV) with bladder cancer in Croatian patients. (23959475)
2013
10
Kaposi's sarcoma: a computational approach through protein-protein interaction and gene regulatory networks analysis. (23266878)
2013
11
Development of whole-virus multiplex luminex-based serological assays for diagnosis of infections with kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 homologs in macaques. (23345584)
2013
12
False-Negative Results of Endoscopic Biopsy in the Diagnosis of Gastrointestinal Kaposi's Sarcoma in HIV-Infected Patients. (23227427)
2012
13
Phase II study of bevacizumab in patients with HIV-associated Kaposi's sarcoma receiving antiretroviral therapy. (22430271)
2012
14
Impact of antiretroviral therapy on the incidence of Kaposi's sarcoma in resource-rich and resource-limited settings. (22729153)
2012
15
Geographical patterns of Kaposi's sarcoma, nonHodgkin lymphomas, and cervical cancer associated with HIV infection in five African populations. (21955799)
2012
16
Uncommon diagnosis of oral Kaposi's sarcoma in an elderly human immunodeficiency virus-seronegative adult. (22690990)
2012
17
Kaposi's sarcoma in an atopic dermatitis patient: a case report and a review of literature. (21385206)
2011
18
Histone demethylase JMJD2A regulates Kaposi's sarcoma-associated herpesvirus replication and is targeted by a viral transcriptional factor. (21228229)
2011
19
Mutational analysis of the latency-associated nuclear antigen DNA-binding domain of Kaposi's sarcoma-associated herpesvirus reveals structural conservation among gammaherpesvirus origin-binding proteins. (20484563)
2010
20
Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. (19939918)
2010
21
Localisation of Mediterranean Kaposi's sarcoma in Morgagni's ventricle. (21302693)
2010
22
Coexistent Kaposi's sarcoma and atypical mycobacterial infection involving lymph node: a case report and review of literature. (21045424)
2010
23
Activation of Akt through gp130 receptor signaling is required for Kaposi's sarcoma-associated herpesvirus-induced lymphatic reprogramming of endothelial cells. (18579585)
2008
24
Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression. (17652396)
2007
25
Intracellular Tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus: role of JAK/STAT signaling. (17151125)
2007
26
The insulin receptor is essential for virus-induced tumorigenesis of Kaposi's sarcoma. (17001305)
2007
27
Identification and characterization of the Orf49 protein of Kaposi's sarcoma-associated herpesvirus. (16501115)
2006
28
Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus. (16585191)
2006
29
Apoptotic effect of ganciclovir on primary effusion lymphoma cells infected with Kaposi's sarcoma-associated herpesvirus. (16838851)
2006
30
RhoA-GTPase facilitates entry of Kaposi's sarcoma-associated herpesvirus into adherent target cells in a Src-dependent manner. (17005646)
2006
31
Activation of mitogen-activated protein kinase and NF-kappaB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane protein. (12915550)
2003
32
Immune activation in AIDS related Kaposi's sarcoma]. (12734931)
2003
33
Human herpesvirus 8-associated primary effusion lymphoma in HIV--patients: a clinicopidemiologic variant resembling classic Kaposi's sarcoma. (11940475)
2002
34
Kaposi's sarcoma-associated herpesvirus LANA2 is a B-cell-specific latent viral protein that inhibits p53. (11119611)
2001
35
Immunomodulatory treatment with low-dose interferon-alpha and oral retinoic acid in lymphangioma-like Kaposi's sarcoma. (10769722)
2000
36
Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) open reading frame 36 protein is a serine protein kinase. (10725434)
2000
37
FGF4 and INT2 oncogenes are amplified and expressed in Kaposi's sarcoma. (10786811)
2000
38
The role of vascular endothelial growth factor (VEGF) in AIDS-related Kaposi's sarcoma. (10804088)
2000
39
Kaposi's sarcoma-associated herpesvirus open reading frame 50/Rta protein activates the entire viral lytic cycle in the HH-B2 primary effusion lymphoma cell line. (10846108)
2000
40
Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas. (10697276)
2000
41
Dihydrofolate reductase from Kaposi's sarcoma-associated herpesvirus. (10683342)
2000
42
Absence of Fas (CD95) and FasL (CD95L) immunohistochemical expression suggests Fas/FasL-mediated apoptotic signal is not relevant in cutaneous Kaposi's sarcoma lesions. (10563496)
1999
43
Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. (10196314)
1999
44
Human interferon-gamma-inducible protein 10 (IP-10) inhibits constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. (9670053)
1998
45
Fibronectin modulates the effects of HIV-1 Tat on the growth of murine Kaposi's sarcoma-like cells through the down-regulation of tyrosine phosphorylation. (9626063)
1998
46
Expression of adhesion molecules in endemic and epidemic Kaposi's sarcoma. (8910041)
1996
47
Expression of transforming growth factor beta and transforming growth factor beta receptors on AIDS-associated Kaposi's sarcoma. (9815902)
1995
48
Possible role of granulocyte-macrophage colony stimulating factor (GM-CSF) on the rapid progression of AIDS-related Kaposi's sarcoma lesions in vivo. (7947290)
1994
49
Histiocytoid hemangioma with features of angiolymphoid hyperplasia and Kaposi's sarcoma. A study by light microscopy, electron microscopy, and immunologic techniques. (6230021)
1983
50
Kaposi's sarcoma and parapsoriasis en plaque in brothers. (5066910)
1972

Variations for Kaposi's Sarcoma

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Expression for genes affiliated with Kaposi's Sarcoma

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Expression patterns in normal tissues for genes affiliated with Kaposi's Sarcoma

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Pathways for genes affiliated with Kaposi's Sarcoma

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Pathways related to Kaposi's Sarcoma according to GeneCards/GeneDecks:

(show all 49)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.2FLT4, VEGFA
2
Show member pathways
10.1FGF4, FGF5
310.1IL6R, IL6, VEGFA
410.1VEGFA, IL6, IL6R
5
Show member pathways
10.0IL6, IFNA2, IFNA1
610.0IL6, IFNA2, IFNA1
710.0IFNA1, IFNA2, IL6
810.0IFNA1, IFNA2, IL6
9
Show member pathways
10.0IL6ST, IL6, IL6R
1010.0IL6ST, IL6, IL6R
1110.0IL6R, IL6, IL6ST
12
Show member pathways
10.0IL6R, IL6, IL6ST
13
Show member pathways
10.0IL6R, IL6, IL6ST
1410.0IL6ST, IL6, IL6R
1510.0IL6R, IL6, IL6ST
16
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
10.0IL6ST, IL6, IL6R
1710.0IL6, IL6R, CD34
1810.0OSM, IL6ST, IL6
1910.0VEGFA, OSM, IL6ST
20
Show member pathways
10.0FGF5, FGF3, FGF4
21
Show member pathways
10.0FGF5, FGF3, FGF4
22
Show member pathways
10.0FGF4, FGF3, FGF5
23
Show member pathways
9.9HGF, IL6R, IL6, IL6ST
24
Show member pathways
9.8STIM1, FGF4, FGF3, FGF5
25
Show member pathways
9.8FGF5, FGF3, FGF4, CYSLTR2
26
Show member pathways
9.8FGF5, FGF3, FGF4, FLT4
27
Show member pathways
9.7FLT4, IL6, HGF, FGF4, FGF5
28
Show member pathways
9.7FLT4, IL6, HGF, FGF4, FGF5
29
Show member pathways
9.7FLT4, IL6, HGF, FGF4, FGF5
30
Show member pathways
9.7FLT4, IL6, HGF, FGF4, FGF5
31
Show member pathways
9.7FGF4, HGF, IL6, FLT4, FGF5
32
Show member pathways
9.7FLT4, IL6, HGF, FGF4, FGF5
33
Show member pathways
Signaling Pathways in Glioblastoma37
9.7VEGFA, HGF, FGF4, FGF3, FGF5
349.7VEGFA, HGF, FGF4, FGF3, FGF5
35
Show member pathways
9.6STIM1, CD34, FGF4, FGF3, FGF5
36
Show member pathways
9.6VEGFA, STIM1, IFNA1, IFNA2, HGF, SLC7A11
37
Show member pathways
9.6IFNA1, IFNA2, IL6ST, IL6, IL6R, HGF
389.6VEGFA, IL6, HGF, FGF4, FGF3, FGF5
39
Show member pathways
9.6FLT4, IL6, HGF, FGF4, FGF3, FGF5
40
Show member pathways
9.5VEGFA, FLT4, HGF, FGF4, FGF3, FGF5
41
Show member pathways
Type III interferon signaling37
9.5OSM, IFNA1, IFNA2, IL6ST, IL6, IL6R
42
Show member pathways
9.5FLT4, IL6ST, IL6, HGF, FGF4, FGF5
43
Show member pathways
9.3CYSLTR2, VEGFA, FLT4, CCR8, FGF4, FGF3
44
Show member pathways
9.2OSM, FGF5, FGF4, HGF, IL6R, IL6
45
Show member pathways
9.2FGF4, HGF, IL6R, IL6, CCR8, FLT4
46
Show member pathways
9.2OSM, FLT4, CCR8, IL6, IL6R, HGF
47
Show member pathways
9.1FLT4, IFNA1, IFNA2, IL6, IL6R, HGF
48
Show member pathways
8.9CCR8, FLT4, OSM, VEGFA, IFNA1, IFNA2
498.8FGF5, VEGFA, OSM, FLT4, IFNA1, IFNA2

Compounds for genes affiliated with Kaposi's Sarcoma

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Compounds related to Kaposi's Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1pegasys4410.4IFNA1, IFNA2
2azd 21714410.4FLT4, VEGFA
3filgrastim44 1111.4OSM, IFNA2, IL6, HGF
4temozolomide44 1111.4VEGFA, IFNA1, IFNA2
5imiquimod44 61 28 1113.4IFNA1, IFNA2, IL6
6isotretinoin44 1111.3HGF, IFNA2, IFNA1
7sunitinib44 50 1112.3VEGFA, FLT4, IFNA1
82,5-oligoadenylate4410.3IFNA1, IFNA2, IL6, TAT
9tocilizumab44 1111.3IL6, IL6R
10neopterin4410.3IL6R, IL6, IFNA2, IFNA1
11entecavir4410.3IFNA1, IFNA2
12rituximab44 50 1112.3IFNA1, IFNA2, IL6, IL6R
13suramin44 28 1112.3FGF4, HGF, IL6R, VEGFA
14ccl344 2811.2TAT, IL6, IFNA1, CCR8
15neomycin4410.2LYVE1, HGF, TAT, FGF4
16gp 1304410.2OSM, IL6ST, IL6, IL6R
17ursodeoxycholic acid44 24 1112.2HGF, IFNA2, IFNA1
18tgf beta14410.2OSM, IL6, HGF, FGF4
19indomethacin44 28 61 1113.2OSM, IFNA2, IL6, HGF, TAT
20acth4410.1CYSLTR2, OSM, IFNA2, IL6ST, IL6
21cyclophosphamide44 50 1112.1VEGFA, IFNA1, IFNA2, HGF
22infliximab44 50 1112.1IL6, IFNA2, VEGFA
23hyaluronic acid44 2411.1VEGFA, OSM, LYVE1, IL6, HGF
24matrigel4410.1VEGFA, OSM, FLT4, HGF, FGF4
25thalidomide44 50 61 1113.1VEGFA, IFNA1, IFNA2, IL6, IL6R, HGF
26actinomycin d4410.1TAT, HGF, IL6, IFNA1, VEGFA
27leucovorin44 50 1112.0IFNA2, IFNA1, VEGFA
28genistein44 28 61 2 24 1115.0VEGFA, OSM, IL6ST, IL6, HGF, TAT
29ifn-alpha4410.0OSM, IFNA1, IFNA2, IL6ST, IL6, IL6R
30cyclosporin a44 28 6111.9IFNA1, IL6, IL6R, HGF, TAT
31histamine44 28 2411.9CYSLTR2, OSM, IFNA2, IL6, IL6R, HGF
32estradiol44 24 1111.9TAT, HGF, IL6R, LYVE1, OSM
33rantes449.9OSM, CCR8, IFNA1, IL6, IL6R, TAT
34prednisolone44 28 1111.9IFNA1, IFNA2, IL6ST, IL6, IL6R, HGF
35sorafenib44 50 1111.9VEGFA, FLT4, IFNA1
36paraffin449.9VEGFA, FLT4, LYVE1, HGF, CD34
37pge2449.9CYSLTR2, VEGFA, OSM, IL6ST, IL6, IL6R
38heparin44 28 24 1112.8CYSLTR2, VEGFA, HGF, TAT, FGF4, FGF3
39oxygen44 2410.8CYSLTR2, FLT4, IFNA2, HGF, TAT, SLC7A11
40cycloheximide449.7VEGFA, OSM, IFNA1, IL6ST, IL6, IL6R
41lipid449.7CYSLTR2, OSM, IFNA2, IL6ST, IL6, IL6R
42agar449.7OSM, IFNA2, IL6ST, HGF, TAT, CD34
43methotrexate50 44 1111.7IL6, IL6R, HGF, TAT
44alanine449.6OSM, LYVE1, IFNA1, IFNA2, IL6ST, IL6
45dexamethasone44 50 28 1112.6VEGFA, OSM, FLT4, IFNA1, IL6ST, IL6
46thymidine44 2410.4OSM, LYVE1, IFNA1, IFNA2, IL6, IL6R
47retinoic acid44 2410.2IFNA2, IFNA1, FLT4, OSM, IL6ST, IL6
48estrogen449.2VEGFA, OSM, FLT4, LYVE1, IFNA2, IL6ST
49tyrosine448.7IFNA2, IFNA1, FLT4, OSM, VEGFA, CYSLTR2
50vegf448.4FGF5, CYSLTR2, VEGFA, OSM, FLT4, LYVE1

GO Terms for genes affiliated with Kaposi's Sarcoma

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Cellular components related to Kaposi's Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oncostatin-M receptor complexGO:00590010.1IL6ST, OSM
2interleukin-6 receptor complexGO:0058969.9IL6ST, IL6, IL6R
3extracellular regionGO:0055769.0FGF5, VEGFA, FLT4, IFNA2, IL6ST, IL6
4extracellular spaceGO:0056159.0VEGFA, OSM, IFNA2, IL6ST, IL6, IL6R

Biological processes related to Kaposi's Sarcoma according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1hepatic immune responseGO:00238410.6IL6R, IL6
2negative regulation of collagen biosynthetic processGO:03296610.6IL6R, IL6
3neutrophil mediated immunityGO:00244610.5IL6R, IL6
4positive regulation of protein kinase C signalingGO:09003710.5VEGFA, FLT4
5ciliary neurotrophic factor-mediated signaling pathwayGO:07012010.5IL6ST, IL6R
6positive regulation of leukocyte chemotaxisGO:00269010.5IL6, IL6R
7negative regulation of neuron deathGO:190121510.5CD34, IL6
8negative regulation of hormone secretionGO:04688810.5OSM, IL6
9negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04315410.5HGF, IL6, VEGFA
10interleukin-6-mediated signaling pathwayGO:07010210.4IL6ST, IL6, IL6R
11positive regulation of chemokine productionGO:03272210.4IL6, IL6R
12monocyte chemotaxisGO:00254810.4IL6R, IL6
13positive regulation of peptidyl-serine phosphorylationGO:03313810.4IL6, OSM, VEGFA
14glutamate metabolic processGO:00653610.4TAT, CD34
15positive regulation of acute inflammatory responseGO:00267510.4IL6, IL6ST, OSM
16cellular response to vascular endothelial growth factor stimulusGO:03592410.3VEGFA, FLT4
17positive regulation of angiogenesisGO:04576610.3CD34, VEGFA, CYSLTR2
18positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.3IL6R, IL6, IL6ST, IFNA2
19positive regulation of osteoblast differentiationGO:04566910.3IL6ST, IL6, IL6R, HGF
20positive regulation of protein phosphorylationGO:00193410.3FGF4, FLT4, VEGFA
21positive regulation of ERK1 and ERK2 cascadeGO:07037410.3CYSLTR2, FLT4, IL6, FGF4
22positive regulation of MAPK cascadeGO:04341010.3IL6R, IL6, FLT4, OSM
23positive regulation vascular endothelial growth factor productionGO:01057510.3IL6ST, FLT4
24cytokine-mediated signaling pathwayGO:01922110.3IFNA2, IL6ST, IL6, IL6R
25defense response to Gram-negative bacteriumGO:05082910.2IL6R, IL6
26vascular endothelial growth factor receptor signaling pathwayGO:04801010.2VEGFA, FLT4
27positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.2VEGFA, OSM, IL6, IL6R, HGF
28blood coagulationGO:00759610.2VEGFA, STIM1, IFNA2, HGF, SLC7A11
29cell-cell signalingGO:00726710.2FGF5, FGF3, FGF4, IFNA2
30phosphatidylinositol-mediated signalingGO:04801510.1FGF5, FGF3, FGF4
31positive regulation of cell divisionGO:05178110.1VEGFA, OSM, FGF4, FGF3, FGF5
32insulin receptor signaling pathwayGO:00828610.0FGF5, FGF3, FGF4
33positive regulation of transcription from RNA polymerase II promoterGO:04594410.0FGF4, HGF, IL6, OSM, VEGFA
34negative regulation of apoptotic processGO:04306610.0VEGFA, FLT4, IL6ST, IL6, HGF, FGF4
35fibroblast growth factor receptor signaling pathwayGO:0085439.9FGF5, FGF3, FGF4
36hyaluronan metabolic processGO:0302129.8HGF, LYVE1
37positive regulation of cell proliferationGO:0082849.5FGF5, VEGFA, OSM, FLT4, IL6ST, IL6

Molecular functions related to Kaposi's Sarcoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1interleukin-6 bindingGO:01998110.3IL6ST, IL6R
2chemoattractant activityGO:04205610.2HGF, VEGFA
3interleukin-6 receptor activityGO:00491510.2IL6ST, IL6R
4interleukin-6 receptor bindingGO:00513810.2IL6ST, IL6, IL6R
5fibroblast growth factor receptor bindingGO:00510410.1FGF5, FGF3, FGF4
6ciliary neurotrophic factor receptor activityGO:00489710.1IL6R, IL6ST
7cytokine activityGO:0051259.9VEGFA, OSM, IFNA2, IL6
8growth factor activityGO:0080839.6FGF5, FGF3, FGF4, HGF, IL6, OSM
9protein bindingGO:0055158.6VEGFA, FLT4, STIM1, CCNK, IFNA2, IL6ST

Products for genes affiliated with Kaposi's Sarcoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Kaposi's Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet