Kaposi's Sarcoma malady

MedlinePlus: Kaposi's sarcoma is a cancer that causes patches of abnormal tissue to grow under the skin, in the lining of the mouth, nose, and throat or in other organs. the patches are usually red or purple and are made of cancer cells and blood cells. the red and purple patches often cause no symptoms, though they may be painful. if the cancer spreads to the digestive tract or lungs, bleeding can result. lung tumors can make breathing hard. before the hiv/aids epidemic, ks usually developed slowly. in hiv/aids patients, though, the disease moves quickly. treatment depends on where the lesions are and how bad they are. treatment for hiv itself can shrink the lesions. however, treating ks does not improve survival from hiv/aids itself. nih: national cancer institute²³

MalaCards: Kaposi's Sarcoma, also known as kaposi sarcoma, is related to sarcoma and classic kaposi sarcoma. An important gene associated with Kaposi's Sarcoma is SLC7A11 (solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11), and among its related pathways are Cytokine production by Th17 cells in CF and Immune response IL-9 signaling pathway. The drugs dactinomycin and etoposide and the compounds rantes and ifn-alpha have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and heart, and related mouse phenotypes are homeostasis/metabolism and cellular.

Disease Ontology: A connective tissue cancer that derives from lymphatic endothelium, and derives from spindle cells, results in formation of vascular channels that fill with blood cells, has material basis in human herpesvirus 8 (hhv8).⁶

OMIM: 148000

Aliases & Descriptions:

kaposi's sarcoma 6 23 kaposi sarcoma 33 32 43 kaposi's sarcoma of lymph nodes 6 43 gallbladder kaposi's sarcoma 6 43 cardiac kaposi's sarcoma 6 43 gastric kaposi's sarcoma 6 43 kaposi's sarcoma of skin 6 43 kaposi sarcoma of the central nervous system 43 kaposi's sarcoma of soft tissues (disorder) 6 kaposi's sarcoma of gastrointestinal sites 6 kaposi's sarcoma of conjunctiva (disorder) 6 kaposi's sarcoma of soft tissue (disorder) 6 kaposi's sarcoma of lymph nodes (disorder) 6 kaposi's sarcoma of central nervous system 6 central nervous system kaposi's sarcoma 6 kaposi's sarcoma of cornea (disorder) 6 kaposi's sarcoma of palate (disorder) 6 kaposi's sarcoma of lung (disorder) 6 kaposi's sarcoma of the gallbladder 6 kaposi's sarcoma of skin (disorder) 6 lymphadenopathic kaposi's sarcoma 6 kaposi's sarcoma of the prostate 6 kaposi's sarcoma of soft tissue 43 kaposi's sarcoma of conjunctiva 43 lymphadenopathic kaposi sarcoma 43 conjunctival kaposi's sarcoma 6

kaposi's sarcoma of esophagus 6 soft tissue kaposi's sarcoma 6 lymph node kaposi's sarcoma 6 kaposi's sarcoma of the cns 6 esophageal kaposi's sarcoma 6 intestinal kaposi's sarcoma 6 cutaneous kaposi's sarcoma 6 pulmonary kaposi's sarcoma 6 kaposi's sarcoma of palate 43 kaposi's sarcoma of cornea 43 kaposi's sarcoma of heart 6 esophageal kaposi sarcoma 43 kaposi's sarcoma of penis 6 prostate kaposi's sarcoma 6 kaposi's sarcoma of anus 6 kaposi's sarcoma of lung 43 corneal kaposi's sarcoma 6 palate kaposi's sarcoma 6 prostate kaposi sarcoma 43 kaposi's sarcoma, skin 6 penis kaposi's sarcoma 6 kaposi's sarcoma, lung 6 penile kaposi sarcoma 43 anal kaposi's sarcoma 6 anal kaposi sarcoma 43 kaposis sarcoma 8

Diseases related to kaposi's sarcoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 753)

id	Related Disease	Score	Top Affiliating Genes
1	sarcoma	60.6	ZNF426, PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1
2	classic kaposi sarcoma	39.4	VWF, VEGFA, B2M, CD34, FCGR3A, IL10
3	leukemia	38.9	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2A
4	immunodeficiency	38.7	PIK3CD, PARP1, CFLAR, CD209, CD28, CD4
5	primary effusion lymphoma	35.6	PIK3CA, VEGFA, VDR, MYC, PARP1, BCL2
6	angiosarcoma	35.2	PIK3CG, KIT, VWF, VIM, VEGFA, VEGFC
7	acquired immunodeficiency syndrome	35.0	SELE, VEGFA, VCAM1, MYC, BCL2, BCL6
8	hemangioendothelioma	34.3	VWF, VEGFA, KDR, CD34, FLT1, FLI1
9	herpes simplex	33.4	PIK3CA, PIK3CG, PCNA, VIM, VEGFA, VDR
10	uveitis	33.2	SELE, VEGFA, B2M, CD14, CD4, CD40
11	hemangioma	32.8	RELA, VWF, RB1, SELE, SETD2, VEGFA
12	non-hodgkin lymphoma	32.1	VDR, MYC, BCL2, BCL2L1, BCL6, CHUK
13	lymphangioma	32.1	VEGFC, KDR, CD34, FLT4, IFNA2, IFNG
14	castleman's disease	32.1	VEGFA, B2M, MIR210, IL10, IL6, IL6R
15	arthritis	32.0	PIK3CD, PIK3CG, PDE4A, RELA, RELB, KIT
16	tuberculosis	31.8	VDR, CD209, IL10, IL1B, IL4, CCL2
17	rheumatoid arthritis	31.0	PIK3CD, PIK3CG, PDE4A, RELA, RELB, KIT
18	hodgkin's lymphoma	30.9	PIK3R1, PIK3CG, SELP, BCL2, BCL2L1, BCL6
19	dermatofibrosarcoma protuberans	30.7	KIT, VIM, P4HTM, CD34, MMP2, F13A1
20	neutropenia	30.7	BCL2, UGT1A1, JAK2, CD14, CD34, CD40
21	dermatofibrosarcoma	30.5	KIT, VIM, P4HTM, CD34, MMP2, MDM2
22	anemia	30.4	RELA, KIT, VWF, PCNA, RB1, SELE
23	mycosis fungoides	30.4	KIT, PCNA, SELE, SELP, VCAM1, BCL2
24	t-cell leukemia	30.3	PIK3CG, RELA, MYC, RAF1, BCL2, BCL2L1
25	hypoxia	30.2	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
26	cellulitis	30.1	SETD2, MTOR, JUN, CD36, FLT4, IL1R1
27	leukopenia	29.7	UGT1A1, CD4, ITGB2, IL16, IL1B, IL3
28	sickle cell anemia	29.5	RELA, VWF, SELE, SELP, VCAM1, UGT1A1
29	malignant mesothelioma	29.2	PIK3CG, KIT, PCNA, RB1, VIM, VEGFA
30	leishmaniasis	28.2	PIK3C2A, RELA, JUN, JAK2, CD209, CD28
31	retinoblastoma	27.4	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, KIT
32	ischemia	27.1	PIK3CA, PIK3C2A, PIK3CG, PDE4A, RELA, VWF
33	carcinoma	19.3	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2B
34	viral infectious disease	17.4	PIK3CG, PDE4A, RELA, VTN, RAF1, USO1
35	gonococcal synovitis	16.8	PIK3CB, PIK3CA, PIK3R1, PIK3CG, PDE4A, RELA
36	prostatitis	15.8	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2B
37	disseminated intravascular coagulation	15.7	PIK3C2A, VWF, VTN, SELE, VEGFA, CD14
38	atopic dermatitis	15.5	PDE4A, SELE, SELP, VCAM1, LGALS3, LBR
39	ulcerative colitis	15.5	PDE4A, SELE, SELP, CD28, CD14, ITGA5
40	systemic lupus erythematosus	15.4	VWF, VTN, SELE, VCAM1, LBR, CFI
41	diffuse large b-cell lymphoma	15.4	PIK3CA, PIK3CG, PDE4A, RELA, KIT, RB1
42	bullous pemphigoid	15.2	SELE, VEGFA, VCAM1, RAC1, CD40, ITGB1
43	human immunodeficiency virus infectious disease	15.2	B2M, CD209, CD28, CDK9, CD14, CD4
44	eczema	15.2	SELE, LGALS3, LBR, CD14, FCER2, IL10
45	commensal bacterial infectious disease	15.1	PIK3CA, CHUK, LBR, CFI, CD14, CD9
46	plasmacytoma	15.1	VEGFA, MYC, LIFR, BCL2, BCL2L1, BCL6
47	skin disease	15.1	PDE4A, VTN, SELE, VDR, CHUK, CD40
48	critical limb ischemia	15.0	VWF, SELE, VEGFA, AXL, CD40, FGF1
49	cutaneous leishmaniasis	15.0	PIK3C2A, FLI1, FCER2, IL10, IL13, IL4
50	autoimmune hepatitis	15.0	VDR, UGT1A1, BAX, CD28, CD14, IL10

Clinical features from OMIM: 148000

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 alitretinoin, dactinomycin, daunorubicin citrate liposome, doxorubicin hydrochloride liposome, etoposide, etoposide phosphate, paclitaxel, vinblastine, vinblastine sulfate

MalaCards organs/tissues related to kaposi's sarcoma:

²²

MGI Mouse Phenotypes related to kaposi's sarcoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2A
2	cellular phenotype	MP:0005384	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIK3C3
3	immune system phenotype	MP:0005387	INF	PIK3CD, PIK3C3, PDE4A, RELB, KIT, VWF
4	embryogenesis phenotype	MP:0005380	INF	PIK3CB, PIK3CA, PIK3C3, KIT, KIF3A, RBL2
5	digestive/alimentary phenotype	MP:0005381	INF	RELB, KIT, KIF3A, VWF, RB1, RBPJ
6	muscle phenotype	MP:0005369	INF	PIK3CA, PIK3R2, PIK3R1, PIK3CG, PIK3C3, RELA
7	normal phenotype	MP:0002873	12.1	PIK3R1, PIK3C3, RELA, VTN, BUB1, RBL2
8	respiratory system phenotype	MP:0005388	11.7	RELB, KIF3A, RBPJ, SELP, BCL6, YY1
9	reproductive system phenotype	MP:0005389	10.8	PIK3CA, BUB1, RBL2, BRD4, VEGFA, VDR
10	renal/urinary system phenotype	MP:0005367	10.6	KIT, KIF3A, RBPJ, SELP, BRAF, PAX2
11	other phenotype	MP:0005395	9.6	RELB, BUB1, KDR, JAK2, ITGB1, ITGB3
12	skeleton phenotype	MP:0005390	9.1	PIK3CD, PIK3CG, RELA, KIT, KIF3A, RB1
13	hearing/vestibular/ear phenotype	MP:0005377	8.0	KIT, RB1, VDR, MYC, PARP1, PAX2
14	growth/size phenotype	MP:0005378	INF	PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, PIK3C3
15	adipose tissue phenotype	MP:0005375	INF	PIK3CA, PIK3R1, PIK3C2A, RB1, BRAF, BRD2
16	mortality/aging	MP:0010768	INF	PIK3CB, PIK3CA, PIK3C2A, PIK3C3, RELA, RELB
17	liver/biliary system phenotype	MP:0005370	INF	PIK3C3, RELB, KIT, BUB1, BRD2, BRD4
18	vision/eye phenotype	MP:0005391	INF	PIK3CA, RELA, KIT, KIF3A, RB1, RBL2
19	integument phenotype	MP:0010771	INF	PIK3C2B, PIK3CG, RELA, RELB, KIT, RB1
20	no phenotypic analysis	MP:0003012	INF	PIK3CD, PIK3R1, PIK3C2B, PCNA, BUB1, RB1
21	hematopoietic system phenotype	MP:0005397	INF	KIT, PCNA, BUB1, RBPJ, RBM15, BST2
22	tumorigenesis	MP:0002006	INF	PIK3CB, PIK3CA, PIK3R2, PIK3R1, KIT, BUB1
23	craniofacial phenotype	MP:0005382	INF	KIT, KIF3A, BRD4, BAMBI, , GSK3B
24	cardiovascular system phenotype	MP:0005385	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
25	limbs/digits/tail phenotype	MP:0005371	INF	RELA, RELB, KIT, KIF3A, RB1, RBL2
26	nervous system phenotype	MP:0003631	INF	PDE4A, RELA, KIT, VWF, RB1, RBFOX2
27	pigmentation phenotype	MP:0001186	INF	KIT, RB1, RBPJ, BRAF, MYC, RAC1
28	behavior/neurological phenotype	MP:0005386	INF	PIK3CA, PIK3C3, RELB, KIT, KIF3A, RB1
29	endocrine/exocrine gland phenotype	MP:0005379	INF	RELB, BUB1, RBL2, RBPJ, BRD2, BRD4

Articles related to kaposi's sarcoma:

(show top 50)    (show all 516)

id	Title	Authors	Year	Affiliating Genes
1	PI3KI^ mediates kaposi's sarcoma-associated herpesviru s vGPCR-induced sarcomagenesis. (21665152)	Martin D.... Gutkind J.S.	2011	PIK3CG
2	Ribosomal protein S6 interacts with the latency-assoc iated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. (21734034)	Chen W.... Dittmer D.P.	2011	RPS6
3	Regulation of tumor necrosis factor-like weak inducer of apoptosis receptor protein (TWEAKR) expression by Kaposi's sarcoma-associat ed herpesvirus microRNA prevents TWEAK-induced apoptosis and inflammatory cytok ine expression. (20844036)	Abend J.R.... Ziegelbauer J.M.	2010	TNFRSF12A
4	Pivotal advance: Kaposi's sarcoma-associated herpesvi rus (KSHV)-encoded microRNA specifically induce IL-6 and IL-10 secretion by mac rophages and monocytes. (20052801)	Qin Z.... Parsons C.H.	2010	IL6, IL10
5	Spindle cells from AIDS-associated Kaposi's sarcoma l esions express telomerase activity that is enhanced by Kaposi's sarcoma progres sion factors. (20514465)	Barillari G.... Ensoli B.	2010	IFNG, TAT
6	Kaposi's sarcoma-associated herpesvirus RTA promotes degradation of the Hey1 repressor protein through the ubiquitin proteasome path way. (19369342)	Gould F.... Whitehouse A.	2009	HEY1
7	Kaposi's sarcoma-associated herpesvirus (KSHV) Rta and cellular HMGB1 proteins synergistically transactivate the KSHV ORF50 promoter. (18692049)	Harrison S.M.... Whitehouse A.	2008	HMGB1
8	Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. (18974867)	Boyne J.R.... Whitehouse A.	2008	NXF1, THOC1, THOC5
9	The effects of human herpesvirus 8 infection and interferon-gamma response in cutaneous lesions of Kaposi sarcoma differ among human immunodeficiency virus-infected and uninfected individuals. (18644020)	Guedes F.... Duarte M.I.	2008	IFNG
10	Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor. (18045938)	Garrigues H.J.... Rose T.M.	2008	ITGAV, ITGB3
11	Sulfated polymannuroguluronate, a novel anti-AIDS drug candidate, inhibits HIV-1 Tat-induced angiogenesis in Kaposi's sarcoma cells. (17868650)	Lu C.X.... Geng M.Y.	2007	TAT
12	Conservation of virally encoded microRNAs in Kaposi sarcoma--associated herpesvirus in primary effusion lymphoma cell lines and in patients with Kaposi sarcoma or multicentric Castleman disease. (17262705)	Marshall V.... Whitby D.	2007	KRT15
13	Essential role of RBP-Jkappa in activation of the K8 delayed-early promoter of Kaposi's sarcoma-associated herpesvirus by ORF50/RTA. (17055026)	Wang Y.... Yuan Y.	2007	RBPJ
14	The Galpha12/13 family of heterotrimeric G proteins and the small GTPase RhoA link the Kaposi sarcoma-associated herpes virus G protein-coupled receptor to heme oxygenase-1 expression and tumorigenesis. (17881360)	Martin M.J.... Marinissen M.J.	2007	HMOX1, RHOA
15	Identifying cellular genes crucial for the reactivation of Kaposi's sarcoma-associated herpesvirus latency. (16476973)	Bryan B.A.... Akula S.M.	2006	RRM1, PPARD, MYBL2
16	Ets-1-dependent expression of vascular endothelial growth factor receptors is activated by latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus through interaction with Daxx. (16861237)	Murakami Y.... Fukazawa H.	2006	ETS1, VEGFA, DAXX
17	A common genetic variant in FCGR3A-V158F and risk of Kaposi sarcoma herpesvirus infection and classic Kaposi sarcoma. (15767342)	Brown E.E.... Chanock S.J.	2005	FCGR3A
18	Ki-67 proliferation index in Kaposi's sarcoma after renal transplantation: findings in skin-only cases versus cases with internal-organ involvement. (15964376)	Ozen O.... Demirhan B.	2005	MKI67
19	Efficacy of interferon-alpha for the treatment of Kaposi's sarcoma herpesvirus-associated uveitis. (16226536)	Brasnu E.... Bodaghi B.	2005	IFNA2
20	Kaposi sarcoma-associated herpesvirus (KSHV) induces heme oxygenase-1 expression and activity in KSHV-infected endothelial cells. (14726403)	McAllister S.C.... Moses A.V.	2004	HMOX1
21	Protein kinase CK2 phosphorylation regulates the interaction of Kaposi's sarcoma-associated herpesvirus regulatory protein ORF57 with its multifunctional partner hnRNP K. (15486205)	Malik P.... Clements J.B.	2004	HNRNPK
22	Paclitaxel for anthracycline-resistant AIDS-related Kaposi's sarcoma: clinical and angiogenic correlations. (14581275)	Stebbing J.... Bower M.	2003	FGF2, TNF
23	Cell cycle arrest by Kaposi's sarcoma-associated herpesvirus replication-associated protein is mediated at both the transcriptional and posttranslational levels by binding to CCAAT/enhancer-binding protein alpha and p21(CIP-1). (12885907)	Wu F.Y.... Hayward G.S.	2003	CEBPA
24	Identification of a novel cellular transcriptional repressor interacting with the latent nuclear antigen of Kaposi's sarcoma- associated herpesvirus. (12941884)	Pan H.-Y.... Gao S.-J.	2003	MLF1IP
25	Kaposi's sarcoma-like tumors in a human herpesvirus 8 ORF74 transgenic mouse. (12552002)	Guo H.G.... Reitz M.	2003	VEGFC
26	Kaposi's sarcoma-associated herpesvirus K-bZIP is a coregulator of K-Rta: physical association and promoter-dependent transcriptional repression. (12502859)	Izumiya Y.... Kung H.J.	2003	CREB3, RBFOX2
27	A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency. (12592400)	Fujimuro M.... Hayward S.D.	2003	CTNNB1
28	HIV protease inhibitors are potent anti-angiogenic mo lecules and promote regression of Kaposi sarcoma. (11875492)	Sgadari C.... Ensoli B.	2002	FGF2
29	Vascular endothelial growth factor levels in serum do not increase following HIV type 1 and HHV8 seroconversion and lack correlation with AIDS-related Kaposi's sarcoma. (12167275)	Renwick N.... Goudsmit J.	2002	VEGFA
30	Differential expression of viral Bcl-2 encoded by Kaposi's sarcoma-associated herpesvirus and human Bcl-2 in primary effusion lymphoma cells and Kaposi's sarcoma lesions. (11836434)	Widmer I.... Erb P.	2002	BCL2
31	Spindle cell conversion by Kaposi's sarcoma-associated herpesvirus: formation of colonies and plaques with mixed lytic and latent gene expression in infected primary dermal microvascular endothelial cell cultures. (11356969)	Ciufo D.M.... Hayward G.S.	2001	STAG1
32	FGF4 and INT2 oncogenes are amplified and expressed in Kaposi's sarcoma. (10786811)	Kiuru-Kuhlefelt S.... Knuutila S.	2000	FGF4, FGF3
33	Human Kaposi's sarcoma cell-mediated tumorigenesis in human immunodeficiency type 1 tat-expressing transgenic mice. (10793108)	Prakash O.... Samaniego F.	2000	TAT
34	Implication of TNF receptor-I-mediated extracellular signal-regulated kinases 1 and 2 (ERK1/2) activation in growth of AIDS-associated Kaposi's sarcoma cells: a possible role of a novel death domain protein MADD in TNF-alpha-induced ERK1/2 activation in Kaposi's sarcoma cells. (10092829)	Murakami-Mori K.... Nakamura S.	1999	MAPK3, TNF
35	Vascular endothelial growth factor-C (VEGF-C) and its receptors KDR and flt-4 are expressed in AIDS-associated Kaposi's sarcoma. (10594750)	Skobe M.... Detmar M.	1999	FLT4, KDR, VEGFC
36	Human interferon-gamma-inducible protein 10 (IP-10) inhibits constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. (9670053)	Geras-Raaka E.... Gershengorn M.C.	1998	GPRC6A
37	Human chorionic gonadotropin in the treatment of HIV-related Kaposi's sarcoma. (9893642)	Tavio M.... Tirelli U.	1998	CGB5
38	Kaposi's sarcoma-associated herpesvirus (KSHV) chemokine vMIP-II and human SDF-1alpha inhibit signaling by KSHV G protein-coupled receptor. (9918794)	Geras-Raaka E.... Gershengorn M.C.	1998	CXCL12
39	Inflammatory cytokines induce the expression of basic fibroblast growth factor (bFGF) isoforms required for the growth of Kaposi's sarcoma and endothelial cells through the activation of AP-1 response elements in the bFGF promoter. (9456251)	Faris M.... Nel A.E.	1998	FGF2, OSM
40	Endogenous basic fibroblast growth factor is essential for cyclin E-CDK2 activity in multiple external cytokine-induced proliferation of AIDS-associated Kaposi's sarcoma cells: dual control of AIDS-associated Kaposi's sarcoma cell growth and cyclin E-CDK2 activity by endogenous and external signals. (9712033)	Murakami-Mori K.... Nakamura S.	1998	FGF1, FGF2, OSM
41	Low molecular weight components but not dimeric HCG inhibit growth and down-regulate AP-1 transcription factor in Kaposi's sarcoma cells. (9275098)	Kachra Z.... Antakly T.	1997	CGA
42	Enhancement of gp130-mediated tyrosine phosphorylation of STAT3 and its DNA-binding activity in dexamethasone-treated AIDS-associated Kaposi's sarcoma cells: selective synergy between dexamethasone and gp130-related growth factors in Kaposi's sarcoma cell proliferation. (9164976)	Murakami-Mori K.... Nakamura S.	1997	STAT3, IL6R, OSM
43	Expression and cytokine regulation of glucocorticoid receptors in Kaposi's sarcoma. (8669484)	Guo W.X.... Gill P.	1996	NR3C1, BCL2A1, OSM
44	Expression of the CD34 antigen distinguishes Kaposi's sarcoma from pseudo-Kaposi's sarcoma (acroangiodermatitis). (8745885)	Kanitakis J.... Claudy A.	1996	CD34
45	Classic (non-AIDS-related) Kaposi's sarcoma in a Japanese patient, successfully treated with alpha-2b-interferon. (7547414)	Shimizu S.... Shimizu H.	1995	IFNA2
46	Regulation of PDGF-B and PDGF receptor expression in the pathogenesis of Kaposi's sarcoma in AIDS. (7826042)	Pistritto G.... D'Onofrio C.	1994	PDGFB
47	Intralesional human leukocyte interferon treatment alone or associated with IL-2 in non-AIDS related Kaposi's sarcoma. (1593018)	Ghyka G.... Coman G.	1992	IFNA1
48	Fibroblast growth factor 6 gene expression in AIDS-associated Kaposi's sarcoma. (1349122)	Huang Y.Q.... Freidman-Kien A.E.	1992	FGF6
49	Tumor growth dependent on Kaposi's sarcoma-derived fibroblast growth factor inhibited by pentosan polysulfate. (1708834)	Wellstein A.... Lippman M.E.	1991	FGF4
50	Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients. (2184372)	Ensoli B.... Wong-Staal F.	1990	CD4, TAT

Genes related to kaposi's sarcoma according to GeneCards:

(show top 50)    (show all 407)

id	Symbol	Description	Score	GeneCards Section Context
1	SLC7A11	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	11.1	Summaries, Publications
2	IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	11.1	Summaries, Publications
3	FGF4	fibroblast growth factor 4	11.1	Aliases & Descriptions, Publications
4	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
5	OSM	oncostatin M	11.0	Publications
6	IFNA2	interferon, alpha 2	11.0	Publications
7	IFNA1	interferon, alpha 1	11.0	Publications
8	VEGFA	vascular endothelial growth factor A	11.0	Publications
9	SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	11.0	Publications
10	TAT	tyrosine aminotransferase	11.0	Publications
11	IL6R	interleukin 6 receptor	11.0	Publications
12	CD34	CD34 molecule	11.0	Publications
13	IL4R	interleukin 4 receptor	11.0	Publications
14	CD9	CD9 molecule	11.0	Publications
15	FGF2	fibroblast growth factor 2 (basic)	11.0	Publications
16	B2M	beta-2-microglobulin	11.0	Publications
17	IFNB1	interferon, beta 1, fibroblast	11.0	Publications
18	TNF	tumor necrosis factor	11.0	Publications
19	IL10	interleukin 10	11.0	Publications
20	CCNK	cyclin K	11.0	Publications
21	CCR8	chemokine (C-C motif) receptor 8	11.0	Publications
22	FGF3	fibroblast growth factor 3	11.0	Publications
23	LYVE1	lymphatic vessel endothelial hyaluronan receptor 1	11.0	Publications
24	FGF5	fibroblast growth factor 5	11.0	Publications
25	CYSLTR2	cysteinyl leukotriene receptor 2	11.0	Publications
26	VIL1	villin 1	11.0
27	CCL1	chemokine (C-C motif) ligand 1	11.0	Publications
28	FCGR3A	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	11.0	Publications
29	CXCR2	chemokine (C-X-C motif) receptor 2	11.0	Publications
30	IL13RA2	interleukin 13 receptor, alpha 2	11.0	Publications
31	TRIM63	tripartite motif containing 63, E3 ubiquitin protein ligase	11.0	Publications
32	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	11.0	Publications
33	KAT5	K(lysine) acetyltransferase 5	11.0	Publications
34	PDPN	podoplanin	11.0	Publications
35	PECAM1	platelet/endothelial cell adhesion molecule 1	11.0	Publications
36	IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	11.0	Publications
37	F13A1	coagulation factor XIII, A1 polypeptide	11.0	Publications
38	FLT4	fms-related tyrosine kinase 4	11.0	Publications
39	CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	11.0	Publications
40	PDGFB	platelet-derived growth factor beta polypeptide	11.0	Publications
41	CGB5	chorionic gonadotropin, beta polypeptide 5	11.0	Publications
42	CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	11.0	Publications
43	TNFRSF8	tumor necrosis factor receptor superfamily, member 8	11.0	Publications
44	CCR3	chemokine (C-C motif) receptor 3	11.0	Publications
45	FGF1	fibroblast growth factor 1 (acidic)	11.0	Publications
46	ACTG1	actin, gamma 1	11.0
47	VEGFC	vascular endothelial growth factor C	11.0	Publications
48	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0	Publications
49	TEK	TEK tyrosine kinase, endothelial	11.0	Publications
50	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications

Pathways related to kaposi's sarcoma according to GeneDecks:

(show top 50)    (show all 503)

id	Pathway	Score	Top Affiliating Genes
1	Cytokine production by Th17 cells in CF41	11.2	RELA, RELB, CHUK, JAK2, CD14, IL6
2	Immune response IL-9 signaling pathway10	11.1	PIK3CB, PIK3CD, PIK3R2, RELA, RAF1, MAP2K2
3	Translation Insulin regulation of translation10	11.1	PIK3CB, PIK3CD, PIK3R2, PIK3R1, RAF1, GSK3B
4	Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR141	11.0	PIK3CB, PIK3CD, PIK3R2, PIK3R1, BAD, MAP2K2
5	Regulation of lipid metabolism Insulin signaling-generic cascades10	11.0	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, GSK3B
6	Phagocytosis of Microbes36	11.0	PIK3R2, PIK3R1, VTN, RAC1, ITGA3, ITGA5
7	Development PDGF signaling via STATs and NF-kB10	10.9	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RELA
8	Fc epsilon RI signaling pathway20	10.9	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
9	Development_GDNF family signaling41	10.9	PIK3CB, PIK3CA, PIK3R2, PIK3R1, RELA, RELB
10	Immune response_IL-23 signaling pathway41	10.9	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, CHUK
11	VEGF Signaling Pathway34	10.8	PIK3C2B, PIK3C2A, VEGFA, VEGFC, RAF1, KDR
12	Immune response_Fc epsilon RI pathway41	10.7	PIK3CB, PIK3CD, PIK3CA, PIK3R2, RELA, RELB
13	Renal cell carcinoma20	10.7	PIK3CB, PIK3CD, PIK3R2, PIK3R1, RAF1, RAC1
14	Signal transduction_PTEN pathway41	10.7	PCNA, BCAR1, ITGA5, ITGB1, GSK3B, IGF1R
15	Immune response CD28 signaling10	10.7	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RELA
16	Allograft rejection20	10.6	CD28, CD40, IL10, IL12A, IL4, IFNG
17	B cell receptor signaling pathway20	10.6	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
18	Translation Non-genomic (rapid) action of Androgen Receptor10	10.6	PIK3R1, RELA, RELB, RAF1, MAP2K1, AKT2
19	Development_A3 receptor signaling41	10.5	PIK3CG, RELA, RELB, MYC, RAF1, CHUK
20	Cytoskeleton remodeling Integrin outside-in signaling10	10.5	VTN, RAF1, RAC1, JUN, ITGA3, ITGA5
21	Development Ligand-independent activation of ESR1 and ESR210	10.5	PIK3CA, PIK3R2, PIK3R1, MAP2K2, MAPK1, MAP2K1
22	Development HGF signaling pathway10	10.5	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RAF1
23	Immune response T cell receptor signaling pathway10	10.4	RELA, RELB, RAF1, RAC1, FYN, CD4
24	Apoptosis and survival_APRIL and BAFF signaling41	10.3	RELA, RELB, BCL2, BCL2A1, BCL2L1, CHUK
25	Development_A2B receptor- action via G-protein alpha s41	10.3	PIK3CB, PIK3CD, PIK3CA, RELA, RELB, BRAF
26	Cell adhesion_PLAU signaling41	10.2	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, VTN
27	Mucin expression in CF via TLRs, EGFR signaling pathways41	10.2	RELA, RELB, RAF1, CHUK, JUN, FOS
28	Colorectal cancer20	10.1	PIK3CB, PIK3CD, PIK3R2, PIK3R1, PIK3CG, BRAF
29	TGF-Beta Pathway36	10.1	PIK3R2, PIK3R1, VEGFC, KDR, BCL2, BAX
30	MAPK Signaling36	10.0	PIK3R2, PIK3R1, KIT, BRAF, VEGFC, MYC
31	T cell receptor signaling pathway20	10.0	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
32	Signal transduction_AKT signaling41	10.0	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RELA
33	Neurotrophin signaling pathway20	9.9	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3CG, RELA
34	CDC42 Pathway36	9.9	KIT, RAF1, LIFR, KDR, AXL, JUN
35	PI3K Signaling in B-Lymphocyte36	9.7	PIK3R1, PIK3C2B, PIK3C2G, PIK3C2A, PIK3C3, RAF1
36	HMGB1 Pathway36	9.7	PIK3R2, PIK3R1, RAC1, JUN, FOS, IL1A
37	Sertoli-Sertoli Cell Junction Dynamics36	9.7	BRAF, RAF1, RAC1, BCAR1, ITGA3, ITGA5
38	TGF-beta Signaling Pathways37	9.5	PIK3CB, PIK3CD, PIK3R2, PIK3R1, PIK3C2B, PIK3CG
39	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR241	9.5	RELA, MYC, RAF1, BCL2, BAX, JUN
40	Development Thrombopoietin-regulated cell processes10	9.4	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, BRAF
41	Development Growth hormone signaling via PI3K/AKT and MAPK cascades10	9.4	PIK3CA, PIK3R1, RAF1, MTOR, CEBPB, JUN
42	Bladder cancer20	8.9	RB1, BRAF, VEGFA, VEGFC, MYC, RAF1
43	Estrogen Pathway36	8.4	PIK3R2, PIK3R1, KIT, BRAF, VEGFC, RAF1
44	all-trans-Retinoic Acid Signaling in Brain36	INF	BCL2, BAX, IL10, IL12A, IL13, IL16
45	Ceramide Pathway36	INF	PIK3R2, PIK3R1, RAF1, BCL2, BAD, JUN
46	Pathways in cancer20	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
47	Chemokine Signaling36	INF	PIK3R2, PIK3R1, BCAR1, XCR1, JUN, JAK2
48	Cellular Apoptosis Pathway36	INF	PIK3R2, PIK3R1, KIT, VEGFC, KDR, BCL2
49	Mitochondrial Apoptosis36	INF	PIK3R2, PIK3R1, KIT, VEGFC, KDR, BCL2
50	Akt Signaling36	INF	PIK3R1, PIK3CG, KIT, VEGFC, RAF1, LIFR

Compounds related to kaposi's sarcoma according to GeneDecks:

(show top 50)    (show all 373)

id	Compound	Score	Top Affiliating Genes
1	rantes32	INF	SELE, SELP, VCAM1, RAC1, CHUK,
2	ifn-alpha32	INF	CDK2, IRF1, IRF3, IRF7, IRF9, IL10
3	genistein32 9 18 9	INF	PIK3CA, PIK3R1, PIK3CG, PCNA, RB1, SELE
4	lipid32	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2B, PIK3C2A
5	dexamethasone32 42 34 9 9	INF	PIK3CA, PIK3R1, PDE4A, VWF, VTN, PCNA
6	wortmannin32 42	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2B, PIK3C2G
7	carbachol32 9 9	INF	, CGA, CTSB,
8	gp 13032	11.2	PIK3R1, KIT, LIFR, BCL2L1, CEBPB, JAK2
9	ivig32	11.2	PIK3C2A, VWF, FCGR3A, IL18R1, IL3, IFNB1
10	methylcellulose32	10.8	KIT, CD14, CD34, FGF2, IL1A, IL3
11	ro 31 822032	10.1	PIK3CG, JUN, MAPK8, MAPK1, MAP2K1, CCL2
12	ns 39832 42	11.0	PIK3CG, PCNA, PARP1, CDKN1B, FGF2, IL1A
13	thymidylate32	9.9	PCNA, RB1, VIM, VEGFA, VDR, MYBL2
14	go 697632 42	10.6	PIK3CG, MMP2, IL8, MAPK8, MAPK3, MAPK14
15	carboplatin32 34 9 9	12.6	RB1, VEGFA, PARP1, KDR, BCL2, CGA
16	Adenosine triphosphate9 18 9	11.4	PIK3CB, PIK3CD, PIK3CA, PIK3C2B, PIK3C2G, PIK3C2A
17	ibmx32	9.2	PDE4A, VCAM1, RAF1, CGA, CGB5, CDK2
18	mitoxantrone32 9 9	11.0	BCL2, MTOR, ATM, IL3, IGF1R, IFNA1
19	4-hydroxytamoxifen32	8.9	MYC, PARP1, JUN, MAPK1, MAP2K1, IGF1
20	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	8.6	PCNA, MYC, PARP1, BCL2, BCL2L1, BAX
21	eb 108932	8.6	PCNA, VDR, PARP1, BCL2, BAX, CDK6
22	losartan32 34 9 9	11.4	VWF, PCNA, SELE, SELP, VCAM1, UGT1A1
23	gf 109203x32 42	9.3	PIK3CB, PIK3CG, VEGFA, RAF1, JUN, JAK2
24	erlotinib32 34 9 9	11.3	PIK3CA, KIT, VEGFA, KDR, MTOR, CDKN1B
25	gefitinib32 34 9 9	9.9	PIK3CA, PIK3CG, KIT, SELP, VIM, VEGFA
26	heparin32 9 18 9	INF	PIK3CA, PIK3C2A, PIK3CG, VWF, VTN, VIM
27	glucose32	INF	PDE4A, KIT, SETD2, BRAF, VEGFC, CHUK
28	curcumin32	INF	PIK3CG, VTN, VEGFA, VCAM1, MYC, RAF1
29	resveratrol32 9 18 9	INF	PIK3CA, PIK3CG, PCNA, RB1, VEGFA, VDR
30	camptothecin32 42 9 9	INF	PIK3CG, PCNA, RB1, SETD2, MYC, PARP1
31	depsipeptide32	INF	RB1, BRAF, MYC, RAF1, BCL2, BCL2L1
32	roscovitine32	INF	PIK3CG, PCNA, VIM, PARP1, BCL2L1, CDK9
33	prostacyclin32	INF	PIK3C2A, PDE4A, VWF, VTN, SELE, SELP
34	paclitaxel32 34 9 9	INF	PIK3CA, PIK3CG, KIT, PCNA, BUB1, RB1
35	butyrate32	INF	PCNA, RB1, SETD2, VIM, VDR, MYC
36	estrogen32	INF	PIK3CB, PIK3R1, VWF, PCNA, SETD2, VEGFC
37	zidovudine32 9 9	INF	MYC, , B2M, CGB5, CD4, CD9
38	retinoic acid32 42 18	INF	PIK3CA, PIK3CG, PDE4A, KIT, VWF, VTN
39	5-aza-2deoxycytidine32	INF	PCNA, VIM, MYC, CFLAR, JAK2, CDKN1A
40	bortezomib32 9 9	INF	SETD2, VEGFA, MYC, PARP1, KDR, BCL2
41	cyclosporin a32 42	INF	PIK3CA, PIK3C2A, PIK3CG, PDE4A, VWF, SELP
42	cyclic amp32 18	INF	PIK3R1, PDE4A, RB1, SETD2, BRAF, RARS
43	threonine32	INF	RBL2, RAF1, PAX2, BCAR1, UNG, CDK6
44	il 1032	INF	VDR, CD40, IL10, IL13, IL1A, IL1B
45	doxorubicin32 34 9 9	INF	PIK3CA, PIK3C2A, PIK3CG, KIT, SELE, SETD2
46	hydrocortisone32 9 9	INF	VIM, KDR, CD36, CD14, CD40, MMP2
47	poly(i-c)32	INF	VCAM1, CHUK, IRF1, IRF3, IRF7, IL1B
48	tetracycline32 9 9	INF	VWF, RB1, RAC1, CDK2, MMP2, MMP9
49	fludarabine32 9 9	INF	PARP1, BCL2, BCL2L1, BAG1, BAX, CDK2
50	heparan sulfate32 18	INF	VTN, VIM, KDR, SDC1, SDC2, SDC4

Cellular components related to kaposi's sarcoma according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	INF	VWF, VTN, VEGFA, VEGFC, LIFR, KDR
2	nucleus	GO:005634	INF	ZNF426, PIK3CB, PIK3C2B, PIK3C2A, PDE4A, RELA
3	extracellular space	GO:005615	INF	KIT, VTN, SELE, SELP, VEGFA, VEGFC
4	cytosol	GO:005829	INF	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2B
5	integral to plasma membrane	GO:005887	12.0	SELP, BST2, LIFR, KDR, SDC1, SDC2
6	transcription export complex	GO:000346	11.2	ALYREF, DDX39B, THOC1, THOC2, THOC3, THOC5
7	cell surface	GO:009986	11.1	BST2, VEGFA, VCAM1, SDC4, AXL, CD36
8	nucleoplasm	GO:005654	10.8	RELA, PCBP1, PCNA, RB1, RBL2, RBPJ
9	ER to Golgi transport vesicle membrane	GO:012507	10.7	B2M, HLA-A, HLA-B, HLA-C, HLA-DQB1, HLA-DRA
10	trans-Golgi network membrane	GO:032588	10.6	AP1B1, AP1M1, AP1S1, AP1S2, AP1S3, HLA-DQB1
11	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.5	HLA-A, HLA-B, HLA-C, HLA-DQB1, HLA-DRA, HLA-DRB1
12	membrane	GO:016020	10.2	PIK3C2G, PIK3CG, PDE4A, VEGFA, VEGFC, BCL2
13	platelet alpha granule lumen	GO:031093	9.6	VWF, VEGFA, VEGFC, FN1, IGF1, F13A1
14	plasma membrane	GO:005886	INF	PIK3CD, PIK3R1, PIK3C2B, PIK3C2A, PIK3CG, KIT
15	external side of plasma membrane	GO:009897	INF	KIT, VWF, SELP, VCAM1, KDR, B2M
16	cytoplasm	GO:005737	INF	PIK3C2A, PIK3CG, RELA, KIT, PCBP1, PCNA
17	membrane raft	GO:045121	INF	SELE, BST2, SDC4, JAK2, CD36, CD14
18	nucleolus	GO:005730	INF	PCNA, RBFOX2, RBL2, RBPJ, RBM15, RBM15B

Biological processes related to kaposi's sarcoma according to GeneDecks:

(show top 50)    (show all 97)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:008284	INF	KIT, VEGFA, VEGFC, MYC, LIFR, KDR
2	signal transduction	GO:007165	INF	PIK3CB, PIK3CD, PDE4A, KIT, BST2, VEGFC
3	positive regulation of cell division	GO:051781	11.8	VEGFA, VEGFC, FGF1, FGF2, FGF3, FGF4
4	negative regulation of transcription, DNA-dependent	GO:045892	11.5	RELA, RB1, RBFOX2, RBPJ, RBM15, RBM15B
5	type I interferon-mediated signaling pathway	GO:060337	11.3	ISG20, IRF1, IRF3, IRF5, IRF7, IRF8
6	insulin receptor signaling pathway	GO:008286	11.2	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3C2A, PIK3C3
7	positive regulation of NF-kappaB transcription factor activity	GO:051092	11.0	RELA, CHUK, UBC, CD40, IL1B, IL6
8	leukocyte migration	GO:050900	11.0	PIK3CB, PIK3CA, PIK3R2, PIK3R1, SELP, FYN
9	negative regulation of transcription from RNA polymerase II promoter	GO:000122	10.9	RBPJ, VDR, MYC, PARP1, PAX2, BCL6
10	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.8	BRAF, KDR, FLT4, FGF2, FGF4, FGFR2
11	MyD88-independent toll-like receptor signaling pathway	GO:002756	10.6	RELA, CHUK, UBC, JUN, FOS, IRF3
12	positive regulation of transcription from RNA polymerase II promoter	GO:045944	10.6	RELA, RB1, RBPJ, VEGFA, VDR, MYC
13	positive regulation of cell migration	GO:030335	10.5	VIL1, VEGFA, KDR, BCAR1, CGA, JAK2
14	fibroblast growth factor receptor signaling pathway	GO:008543	10.5	PIK3CA, PIK3R1, BRAF, RAF1, CHUK, UBC
15	Toll signaling pathway	GO:008063	10.5	RELA, CHUK, UBC, JUN, CD14, FOS
16	T cell costimulation	GO:031295	10.5	PIK3CA, PIK3R2, PIK3R1, RAC1, MTOR, FYN
17	T cell receptor signaling pathway	GO:050852	10.4	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RELA
18	toll-like receptor 4 signaling pathway	GO:034142	10.4	RELA, CHUK, UBC, JUN, CD14, FOS
19	toll-like receptor 3 signaling pathway	GO:034138	10.4	RELA, CHUK, UBC, JUN, CD14, FOS
20	TRIF-dependent toll-like receptor signaling pathway	GO:035666	10.4	RELA, CHUK, UBC, JUN, CD14, FOS
21	negative regulation of apoptotic process	GO:043066	10.3	PIK3CG, RELA, BRAF, VEGFA, MYC, RAF1
22	anti-apoptosis	GO:006916	10.2	PIK3CA, RELA, BRAF, PAX2, BCL2, BCL2A1
23	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.1	KIT, SELP, KDR, JAK2, FLT1, ANGPT1
24	peptidyl-tyrosine phosphorylation	GO:018108	10.1	KIT, KDR, FYN, JAK2, FLT1, FLT4
25	toll-like receptor signaling pathway	GO:002224	10.1	RELA, CHUK, UBC, JUN, FOS, MAPK8
26	MyD88-dependent toll-like receptor signaling pathway	GO:002755	10.1	RELA, CHUK, UBC, JUN, FOS, MAPK8
27	positive regulation of transcription, DNA-dependent	GO:045893	10.1	RELA, RB1, MYC, PAX2, BAMBI, KAT5
28	toll-like receptor 1 signaling pathway	GO:034130	10.0	RELA, CHUK, UBC, JUN, FOS, MAPK8
29	toll-like receptor 2 signaling pathway	GO:034134	10.0	RELA, CHUK, UBC, JUN, FOS, MAPK8
30	activation of MAPK activity	GO:000187	9.9	PIK3CB, KIT, UBC, INSR, FGF2, MET
31	negative regulation of cell proliferation	GO:008285	9.9	VDR, RAF1, BCL6, CIB1, CEBPA, JUN
32	blood coagulation	GO:007596	9.9	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, KIF3A
33	response to hypoxia	GO:001666	9.9	VEGFA, VCAM1, RAF1, BCL2, SDC2, ATM
34	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.8	VTN, VEGFA, MTOR, JAK2, CD36, CD4
35	epidermal growth factor receptor signaling pathway	GO:007173	9.6	PIK3CA, PIK3R1, PIK3C2A, VIL1, RAF1, BCAR1
36	platelet degranulation	GO:002576	9.5	VWF, SELP, VEGFA, VEGFC, CD36, CD9
37	positive regulation of smooth muscle cell proliferation	GO:048661	9.5	JUN, FLT1, IL13, IL6, IL6R, IGF1
38	phosphatidylinositol-mediated signaling	GO:048015	9.3	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3C2B, PIK3C2G
39	platelet activation	GO:030168	9.3	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, VWF
40	nerve growth factor receptor signaling pathway	GO:048011	9.2	PIK3CB, PIK3CA, PIK3R2, PIK3R1, RELA, BRAF
41	response to drug	GO:042493	8.2	PDE4A, VEGFC, MYC, BCL2, UGT1A1, BAG1
42	innate immune response	GO:045087	INF	PIK3CD, PIK3CG, PIK3C3, RELA, BST2, BCL2
43	interferon-gamma-mediated signaling pathway	GO:060333	INF	VCAM1, B2M, JAK2, IRF1, IRF3, IRF5
44	apoptotic process	GO:006915	INF	BUB1, VIM, RAF1, RAC1, RAD21, PACS2
45	cytokine-mediated signaling pathway	GO:019221	INF	RELA, KIT, VCAM1, LIFR, UBC, BAD
46	inflammatory response	GO:006954	INF	PIK3CD, PIK3CG, RELA, KIT, SELE, SELP
47	virus-host interaction	GO:019048	INF	PIK3R1, RELA, BUB1, RB1, RBM15, RBM15B
48	chemotaxis	GO:006935	INF	PIK3CB, PIK3C2G, XCR1, FGF2, IL4, MAPK14
49	immune response	GO:006955	INF	VTN, CHUK, XBP1, CEBPB, CD4, IRF8
50	angiogenesis	GO:001525	INF	PIK3CA, PIK3CG, SETD2, VEGFA, VEGFC, KDR

Molecular functions related to kaposi's sarcoma according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	THOC5, STAG1, PSMC1, PRKCD, PRKCZ, PROX1
2	cytokine activity	GO:005125	12.2	IFNB1, IFNG, HMGB1, TNF, TNFSF14, EDN1
3	platelet-derived growth factor receptor binding	GO:005161	11.1	LYN, VEGFA, ITGA5, ITGB3, IL1R1, PDGFA
4	growth factor activity	GO:008083	11.1	VEGFA, VEGFC, FGF1, FGF2, FGF3, FGF4
5	1-phosphatidylinositol-3-kinase activity	GO:016303	10.7	ATM, PIK3C3, PIK3CG, PIK3C2A, PIK3C2G, PIK3R2
6	protein homodimerization activity	GO:042803	10.4	CR2, NR3C1, SP1, DAXX, PTGS2, TERT
7	protein tyrosine kinase activity	GO:004713	10.3	TEK, PTK2B, SRC, PDGFRB, HCK, TYK2
8	transcription factor binding	GO:008134	10.3	DAXX, SUMO1, TP53, HMGB1, ETS1, SP1
9	protein heterodimerization activity	GO:046982	10.1	MET, IL12A, MCL1, TP53, NR3C1, PDGFA
10	insulin receptor substrate binding	GO:043560	10.1	PIK3CA, PIK3R1, JAK2, INSR, IL4R, IGF1R
11	ATP binding	GO:005524	9.9	PIK3CD, PIK3CA, PIK3C2B, PIK3C2G, PIK3C2A, PIK3CG
12	protein kinase activity	GO:004672	9.9	TRIM28, AKT3, AKT1, CCND1, TEK, PTK2
13	integrin binding	GO:005178	9.9	FCER2, IGF1, ICAM1, SRC, THBS1, LYN
14	enzyme binding	GO:019899	9.4	PTEN, PTGS2, DAXX, CTNNB1, NOTCH1, HIF1A
15	identical protein binding	GO:042802	INF	TP53, TRAF2, AKT1, , IGF1R, TNF
16	sequence-specific DNA binding transcription factor activity	GO:003700	INF	NFKB1, NOTCH1, CREBBP, CREB3, NR3C1, PPARD