MCID: KPS001
MIFTS: 73

Kaposi's Sarcoma malady

Cancer, Infectious categories

Summaries for Kaposi's Sarcoma

Sources:
8Disease Ontology, 34MedlinePlus, 47OMIM, 33MalaCards
See all sources

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MedlinePlus:34 Kaposi's sarcoma is a cancer that causes patches of abnormal tissue to grow under the skin, in the lining of the mouth, nose, and throat or in other organs. the patches are usually red or purple and are made of cancer cells and blood cells. the red and purple patches often cause no symptoms, though they may be painful. if the cancer spreads to the digestive tract or lungs, bleeding can result. lung tumors can make breathing hard. before the hiv/aids epidemic, ks usually developed slowly. in hiv/aids patients, though, the disease moves quickly. treatment depends on where the lesions are and how bad they are. treatment for hiv itself can shrink the lesions. however, treating ks does not improve survival from hiv/aids itself. nih: national cancer institute

MalaCards: Kaposi's Sarcoma, also known as kaposi sarcoma, is related to acquired immunodeficiency syndrome and angiosarcoma. An important gene associated with Kaposi's Sarcoma is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Immune System and PEDF Induced Signaling. The drugs etoposide and etoposide phosphate and the compounds vegf and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are immune system and integument.

Disease Ontology:8 A connective tissue cancer that derives from lymphatic endothelium, and derives from spindle cells, results in formation of vascular channels that fill with blood cells, has material basis in human herpesvirus 8 (hhv8).

Description from OMIM:47 148000

Aliases & Classifications for Kaposi's Sarcoma

Sources:
8Disease Ontology, 9diseasecard, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer, Infectious


Characteristics (Orphanet epidemiological data):

49
kaposi's sarcoma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

kaposi's sarcoma 8 49 34
kaposi sarcoma 47 45 61
kaposi's sarcoma of soft tissue 8 61
kaposi's sarcoma of lymph nodes 8 61
kaposi's sarcoma of conjunctiva 8 61
gallbladder kaposi's sarcoma 8 61
kaposi's sarcoma of palate 8 61
kaposi's sarcoma of cornea 8 61
gastric kaposi's sarcoma 8 61
cardiac kaposi's sarcoma 8 61
kaposi sarcoma of the central nervous system 61
kaposi's sarcoma of central nervous system 8
kaposi's sarcoma of gastrointestinal sites 8
central nervous system kaposi's sarcoma 8
kaposi's sarcoma of the gallbladder 8
kaposi sarcoma, susceptibility to 9
lymphadenopathic kaposi's sarcoma 8
kaposi's sarcoma of the prostate 8
kaposi's sarcoma of soft tissues 8
conjunctival kaposi's sarcoma 8
kaposi's sarcoma of esophagus 8
soft tissue kaposi's sarcoma 8
esophageal kaposi's sarcoma 8
lymph node kaposi's sarcoma 8
intestinal kaposi's sarcoma 8
kaposi's sarcoma of the cns 8
cutaneous kaposi's sarcoma 8
pulmonary kaposi's sarcoma 8
kaposi's sarcoma of heart 8
kaposi's sarcoma of penis 8
prostate kaposi's sarcoma 8
corneal kaposi's sarcoma 8
kaposi's sarcoma of skin 8
kaposi's sarcoma of anus 8
kaposi's sarcoma of lung 8
palate kaposi's sarcoma 8
kaposi's sarcoma, lung 8
kaposi's sarcoma, skin 8
penis kaposi's sarcoma 8
anal kaposi's sarcoma 8
kaposis sarcoma 10


External Ids:

Disease Ontology8 DOID:8632
NCIt40 C9087
OMIM47 148000
ICD9CM27 176.9, 176
MESH via Orphanet36 D012514
ICD10 via Orphanet26 C46
SNOMED-CT via Orphanet58 109385007, 49937004
UMLS via Orphanet62 C0036220

Related Diseases for Kaposi's Sarcoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Kaposi's Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1acquired immunodeficiency syndrome30.9IFNA1, IL6, TAT
2angiosarcoma30.4PECAM1, CD34
3pyogenic granuloma30.4PECAM1, CD34
4tuberculosis30.3TAT
5arthritis30.1OSM, IL6, IL6ST, TAT, PECAM1
6hepatitis b30.1TAT, IFNA1, IFNA2
7hepatitis c30.1IFNA1, IFNA2
8leukopenia30.1IFNA2, IFNA1, IL6
9classic kaposi sarcoma11.0
10castleman's disease10.8
11multicentric castleman’s disease10.8
12multicentric castleman disease10.8
13endemic kaposi sarcoma10.6
14primary effusion lymphoma10.6
15colon kaposi sarcoma10.4
16secondary syphilis10.3
17syphilis10.3
18cryptococcosis10.2
19n syndrome10.2
20kshv inflammatory cytokine syndrome10.2
21membranous glomerulonephritis10.1
22pulmonary tuberculosis10.1
23molluscum contagiosum10.1
24epstein-barr virus hepatitis10.1
25gonadoblastoma10.1
26atopic dermatitis10.1
27hepatitis e10.1
28sickle cell anemia10.1
29follicular dendritic cell sarcoma10.1
30intussusception10.1
31actinomycosis10.1
32penis sarcoma10.1
33ulcerative colitis10.1
34herpes zoster10.1
35paracoccidioidomycosis10.1
36adult lymphoma10.1
37merkel cell carcinoma10.1
38vitiligo10.1
39granuloma annulare10.1
40lymphogranuloma venereum10.1
41hepatitis a10.1
42skin sarcoma10.1
43synovitis10.1
44venous insufficiency10.1
45micro syndrome10.1
46follicular dendritic cell tumor10.1
47follicular lymphoma10.1
48lichen sclerosus10.1
49nephrogenic systemic fibrosis10.1
50angiomatosis10.1

Graphical network of the top 20 diseases related to Kaposi's Sarcoma:



Diseases related to kaposi's sarcoma

Clinical Features for Kaposi's Sarcoma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

148000

Clinical synopsis from OMIM:

148000

Drugs & Therapeutics for Kaposi's Sarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Kaposi's Sarcoma

Anatomical Context for Kaposi's Sarcoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Kaposi's Sarcoma:

33
Bone marrow, Whole blood, Lymph node, Spleen, Brain, Heart, Small intestine, Colon, Kidney, Liver, Lung, Adrenal gland, Breast, Skin, Prostate, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Temporal lobe, Tongue

Animal Models for Kaposi's Sarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Kaposi's Sarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.9CCL1, CCR8, STIM1, VEGFA, CD34, CYSLTR2
2MP:001077111.7OSM, IL6ST, SLC7A11, IL6, FGF5, CYSLTR2
3MP:000539011.4IL6ST, IL6, FGF4, FGF3, VEGFA, STIM1
4MP:000539711.4HGF, STIM1, VEGFA, CD34, IL6, IL6ST

Publications for Kaposi's Sarcoma

Sources:
51PubMed
See all sources

Articles related to Kaposi's Sarcoma:

(show top 50)    (show all 1309)
idTitleAuthorsYear
1
Genomewide Mapping and Screening of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) 3' Untranslated Regions Identify Bicistronic and Polycistronic Viral Transcripts as Frequent Targets of KSHV MicroRNAs. (24155407)
2014
2
The viral interferon regulatory factors of kaposi's sarcoma-associated herpesvirus differ in their inhibition of interferon activation mediated by toll-like receptor 3. (23115281)
2013
3
Kaposi's sarcoma: a computational approach through protein-protein interaction and gene regulatory networks analysis. (23266878)
2013
4
Oral medicine case book 50: HIV associated Kaposi sarcoma. (23971290)
2013
5
Kaposi's-sarcoma-associated-herpesvirus-activated dendritic cells promote HIV-1 trans-infection and suppress CD4(+) T cell proliferation. (23510674)
2013
6
YGLF motif in the Kaposi sarcoma herpes virus G-protein-coupled receptor adjusts NF-I_B activation and paracrine actions. (24292677)
2013
7
Gemcitabine for the Treatment of Classic Kaposi's Sarcoma: A Case Series. (24324093)
2013
8
Lytic infection of Kaposi's sarcoma-associated herpesvirus induces DNA double-strand breaks and impairs non-homologous end joining. (23677788)
2013
9
Utility of immunohistochemical staining with FLI1, D2-40, CD31, and CD34 in the diagnosis of acquired immunodeficiency syndrome-related and non-acquired immunodeficiency syndrome-related Kaposi sarcoma. (22372906)
2012
10
Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma. (23027923)
2012
11
Immune thrombocytopenic purpura and Kaposi's sarcoma in a liver transplant recipient. (22417011)
2012
12
Regional prevalence and transmission route of Kaposi's sarcoma-associated herpes virus in Zhejiang, China. (22490501)
2012
13
Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppression. (21209110)
2011
14
Clinical challenge: cutaneous Kaposi's sarcoma of the lower extremity. (21310005)
2011
15
The single RBP-Jkappa site within the LANA promoter is crucial for establishing Kaposi's sarcoma-associated herpesvirus latency during primary infection. (21507979)
2011
16
Treatment of Disseminated Classic Type of Kaposi's Sarcoma with Paclitaxel. (22148021)
2011
17
Novel regulatory role for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP in chemosensitization to bleomycin. (22037577)
2011
18
Parasite infection is associated with Kaposi's sarcoma associated herpesvirus (KSHV) in Ugandan women. (21962023)
2011
19
Retrospective analysis of the efficacy of gemcitabine for previously treated AIDS-associated Kaposi's sarcoma in western Kenya. (20215784)
2010
20
Kaposi's sarcoma of the head and neck: a review. (20138796)
2010
21
Characterization of entry and infection of monocytic THP-1 cells by Kaposi's sarcoma associated herpesvirus (KSHV): role of heparan sulfate, DC-SIGN, integrins and signaling. (20674951)
2010
22
HLA polymorphisms and detection of kaposi sarcoma-associated herpesvirus DNA in saliva and peripheral blood among children and their mothers in the uganda sickle cell anemia KSHV Study. (21087485)
2010
23
Binding of RBP-Jkappa (CSL) protein to the promoter of the Kaposi's sarcoma-associated herpesvirus ORF47 (gL) gene is a critical but not sufficient determinant of transactivation by ORF50 protein. (20006367)
2010
24
The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade. (18836096)
2009
25
Rapidly eruptive, treatment-resistant, nodular Kaposi's sarcoma in an acquired immunodeficiency syndrome (AIDS) patient on highly active antiretroviral therapy. (19200196)
2009
26
Identification of caspase-mediated decay of interferon regulatory factor-3, exploited by a Kaposi sarcoma-associated herpesvirus immunoregulatory protein. (19553679)
2009
27
X-box binding protein 1 contributes to induction of the Kaposi's sarcoma-associated herpesvirus lytic cycle under hypoxic conditions. (19403667)
2009
28
Classic Kaposi sarcoma with sarcoid-like granulomas: a case report and literature review. (19679122)
2009
29
Weekly paclitaxel for advanced aggressive classic Kaposi sarcoma: experience in 17 cases. (18363766)
2008
30
Concomitant and fatal HHV-8+ multicentric Castleman's disease and Kaposi's sarcoma in the same lymph node of an HIV- liver transplant patient. (17543090)
2007
31
The transcriptional repressor K-RBP modulates RTA-mediated transactivation and lytic replication of Kaposi's sarcoma-associated herpesvirus. (17409159)
2007
32
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes. (16940503)
2006
33
Matrix metalloproteinases in the progression and regression of Kaposi's sarcoma. (17177939)
2006
34
Iatrogenic Kaposi's sarcoma following steroid therapy for nonspecific interstitial pneumonia with HHV-8 genotyping. (16413694)
2006
35
The expression of CD154 by Kaposi's sarcoma cells mediates the anti-apoptotic and migratory effects of HIV-1-TAT protein. (16569346)
2006
36
Antiangiogenic therapy with pioglitazone, rofecoxib, and trofosfamide in a patient with endemic kaposi sarcoma. (15611430)
2004
37
Immune activation in AIDS related Kaposi's sarcoma]. (12734931)
2003
38
Paclitaxel for anthracycline-resistant AIDS-related Kaposi's sarcoma: clinical and angiogenic correlations. (14581275)
2003
39
HIV-1 infection of primary effusion lymphoma cell line triggers Kaposi's sarcoma-associated herpesvirus (KSHV) reactivation. (11857356)
2002
40
Primary effusion lymphoma in an HIV-negative patient with no serologic evidence of Kaposi's sarcoma virus. (11342372)
2001
41
Immunomodulatory treatment with low-dose interferon-alpha and oral retinoic acid in lymphangioma-like Kaposi's sarcoma. (10769722)
2000
42
Novel association of haemophagocytic syndrome with Kaposi's sarcoma-associated herpesvirus-related primary effusion lymphoma. (11167749)
2000
43
Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. (10702388)
2000
44
p38MAP kinase is a negative regulator for ERK1/2-mediated growth of AIDS-associated Kaposi's sarcoma cells. (10543991)
1999
45
Primary effusion lymphoma containing human herpesvirus 8 DNA in two AIDS patients with Kaposi's sarcoma. (9542317)
1998
46
Kaposi's sarcoma and protection from AIDS dementia complex. (9863882)
1998
47
The structure and coding organization of the genomic termini of Kaposi's sarcoma-associated herpesvirus. (9299627)
1997
48
The cyclin encoded by Kaposi's sarcoma-associated herpesvirus stimulates cdk6 to phosphorylate the retinoblastoma protein and histone H1. (9151805)
1997
49
Kaposi's sarcoma in severe alcoholic hepatitis. (9058638)
1997
50
Over-expression of hepatocyte growth factor in human Kaposi's sarcoma. (8567112)
1996

Genetic Variations for Kaposi's Sarcoma

Expression for genes affiliated with Kaposi's Sarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Kaposi's Sarcoma

Search GEO for disease gene expression data for Kaposi's Sarcoma.

Pathways for genes affiliated with Kaposi's Sarcoma

Sources:
54Reactome, 52QIAGEN, 30KEGG, 12EMD Millipore
See all sources

Pathways related to Kaposi's Sarcoma according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.9IFNA1, STIM1, FGF4, IFNA2, HGF, FGF3
2
Hide members
11.9IL6, HGF, CCL1, CCR8, IFNA2, IFNA1
311.7VEGFA, HGF, IFNA1, OSM, IFNA2, FGF5
4
Hide members
11.6OSM, CCR8, CCL1, HGF, IL13RA2, FGF5
5
Hide members
11.6HGF, CCL1, IL13RA2, IL6, FGF4, FGF5
6
Hide members
11.4FGF4, IL13RA2, FGF5, OSM, CCR8, CCL1
711.3FGF4, FGF5, FGF3, VEGFA, HGF, IL6
811.3IFNA2, OSM, IFNA1, IL13RA2, IL6ST, IL6
9
Hide members
11.3FGF5, IL13RA2, CCL1, FGF4, FGF3, HGF
10
Hide members
11.2STIM1, IFNA2, HGF, IFNA1, VEGFA
11
Hide members
11.2IFNA1, IL6ST, IL6, HGF, IFNA2
1211.2FGF3, FGF4, VEGFA, HGF, FGF5
13
Hide members
11.2HGF, VEGFA, FGF3, FGF5, FGF4
14
Immune response Oncostatin M signaling via JAK-Stat in human cells
Hide members
11.0VEGFA, IL6ST, IL6, OSM
15
Hide members
11.0FGF3, FGF4, STIM1, FGF5
16
Hide members
10.9VEGFA, PECAM1, HGF
1710.9IL6, IFNA1, IFNA2
1810.9IL6, IFNA1, IFNA2
1910.9IFNA1, IFNA2, IL6
2010.9IFNA1, IFNA2, IL6
21
Hide members
10.9FGF5, HGF, IL6
22
Hide members
10.9FGF5, FGF4, FGF3
23
Hide members
10.9FGF3, FGF5, FGF4
2410.6PECAM1

Compounds for genes affiliated with Kaposi's Sarcoma

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Kaposi's Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1vegf4512.9PECAM1, HGF, IFNA2, IFNA1, OSM, VEGFA
2tyrosine4512.7VEGFA, OSM, IFNA1, IFNA2, HGF, CD34
3retinoic acid45 2413.3HGF, IFNA2, IFNA1, OSM, CD34, FGF4
4agar4512.0HGF, OSM, CD34, FGF3, FGF4, IL6ST
5thymidine45 2413.0HGF, IFNA2, IFNA1, OSM, CD34, FGF5
6lipid4512.0HGF, IFNA2, OSM, CYSLTR2, IL6, IL6ST
7histamine45 29 2413.9HGF, IFNA2, OSM, CYSLTR2, IL6, TAT
8dexamethasone45 50 29 1114.8HGF, IFNA1, OSM, VEGFA, IL6, IL6ST
9alanine4511.8HGF, IFNA2, IFNA1, OSM, IL6, IL6ST
10prednisolone45 29 1113.7HGF, IFNA2, IFNA1, IL6, IL6ST, TAT
11heparin45 29 11 2414.7VEGFA, CYSLTR2, FGF3, FGF4, TAT, PECAM1
12actinomycin d4511.7HGF, IFNA1, VEGFA, IL6, TAT, PECAM1
13genistein45 29 60 2 11 2416.7HGF, OSM, VEGFA, IL6, IL6ST, TAT
14ccl345 2912.6CCL1, CCR8, IFNA1, IL6, TAT
15ifn-alpha4511.6IL6ST, IL6, OSM, IFNA1, IFNA2
16thalidomide45 50 60 1114.6HGF, IFNA2, IFNA1, VEGFA, IL6
17acth4511.6IFNA2, OSM, CYSLTR2, IL6, IL6ST
18oxygen45 2412.5HGF, CYSLTR2, FGF4, SLC7A11, PECAM1
19rantes4511.5IFNA1, OSM, IL6, PECAM1
20filgrastim45 1112.5HGF, IFNA2, OSM, IL6
21cyclosporin a45 29 6013.5PECAM1, TAT, IL6, IFNA1, HGF
222,5-oligoadenylate4511.4IFNA2, IFNA1, IL6, TAT
23tgf beta14511.4HGF, OSM, FGF4, IL6
24hyaluronic acid45 2412.4IL6, VEGFA, OSM, HGF
25prostacyclin4511.3HGF, VEGFA, CYSLTR2, PECAM1
26cycloheximide4511.3TAT, IFNA1, HGF
27indomethacin45 60 29 1114.3HGF, OSM, TAT
28temozolomide45 1112.3VEGFA, IFNA1, IFNA2
29imiquimod45 29 60 1114.3IFNA2, IFNA1, IL6
30ursodeoxycholic acid45 11 2413.2HGF, IFNA2, IFNA1
31leucovorin45 50 1113.2VEGFA, IFNA1, IFNA2
32infliximab45 50 1113.2IFNA2, VEGFA, IL6
33pge24511.1CYSLTR2, VEGFA
34matrigel4511.1FGF4, PECAM1
35pegasys4511.1IFNA1, IFNA2
36isotretinoin45 1112.1IFNA2, HGF
37entecavir4511.1IFNA1, IFNA2
38estrogen4511.1TAT
39mizoribine4511.0IFNA2, IFNA1
40famciclovir45 1112.0IFNA2, IFNA1
41intron a4511.0IFNA2, IFNA1
42pf 04217903 mesylate6011.0HGF, IL6
43su 112746010.9HGF, IL6
44pha 6657526010.9HGF, IL6
45melphalan45 1111.9IL6, IFNA1, IFNA2
46n-phosphonacetyl-l-aspartate4510.9IFNA2, IFNA1
47rebamipide4510.8HGF, IL6
48ccl445 2911.8CCR8, CCL1, HGF
49crizotinib50 6011.8HGF, IL6
505fluorouracil4510.7HGF, IFNA2, IFNA1, VEGFA

GO Terms for genes affiliated with Kaposi's Sarcoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Kaposi's Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.9PECAM1, HGF, CCL1, IFNA2, OSM, VEGFA
2extracellular regionGO:00557611.6IFNA2, VEGFA, FGF3, FGF5, FGF4, IL6
3oncostatin-M receptor complexGO:00590010.7OSM, IL6ST
4interleukin-6 receptor complexGO:00589610.5IL6, IL6ST

Biological processes related to Kaposi's Sarcoma according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell proliferationGO:00828411.8OSM, VEGFA, FGF3, FGF5, FGF4, IL6
2blood coagulationGO:00759611.6PECAM1, SLC7A11, VEGFA, STIM1, IFNA2, HGF
3positive regulation of cell divisionGO:05178111.5FGF4, FGF5, FGF3, VEGFA, OSM
4positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.4HGF, OSM, VEGFA, IL6
5negative regulation of apoptotic processGO:04306611.3IL6ST, IL6, FGF4, VEGFA, HGF
6signal transductionGO:00716511.3CCL1, CD34, FGF3, FGF4, IL13RA2, PECAM1
7platelet activationGO:03016811.3PECAM1, IL6, VEGFA, HGF
8cytokine-mediated signaling pathwayGO:01922111.3IFNA2, IL6, IL6ST, IL13RA2
9positive regulation of acute inflammatory responseGO:00267511.2IL6ST, IL6, OSM
10positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251711.2IFNA2, IL6, IL6ST
11cell-cell signalingGO:00726711.2IFNA2, FGF3, FGF5, FGF4
12positive regulation of peptidyl-serine phosphorylationGO:03313811.2OSM, VEGFA, IL6
13positive regulation of osteoblast differentiationGO:04566911.2IL6ST, IL6, HGF
14negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04315411.1HGF, VEGFA, IL6
15glomerular endothelium developmentGO:07201111.0PECAM1, CD34
16platelet degranulationGO:00257611.0HGF, VEGFA, PECAM1
17interleukin-6-mediated signaling pathwayGO:07010211.0IL6, IL6ST
18positive regulation of ERK1 and ERK2 cascadeGO:07037410.9IL6, FGF4, CYSLTR2
19negative regulation of hormone secretionGO:04688810.9IL6, OSM
20glutamate metabolic processGO:00653610.7CD34, TAT
21positive regulation of angiogenesisGO:04576610.6VEGFA, CD34, CYSLTR2

Molecular functions related to Kaposi's Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00808311.4IL6, FGF4, FGF5, FGF3, VEGFA, OSM
2fibroblast growth factor receptor bindingGO:00510410.8FGF3, FGF5, FGF4
3interleukin-6 receptor bindingGO:00513810.8IL6ST, IL6
4cytokine activityGO:00512510.7IL6, VEGFA, OSM, IFNA2

Products for genes affiliated with Kaposi's Sarcoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Kaposi's Sarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet