MCD
MCID: KPS001
MIFTS: 85

Kaposi's Sarcoma (MCD) malady

Cancer diseases, Infectious diseases, Rare diseases categories
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Summaries for Kaposi's Sarcoma

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Sources:
8Disease Ontology, 34MedlinePlus, 47OMIM, 33MalaCards
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Fully expand this MalaCard
MedlinePlus:34 Kaposi's sarcoma is a cancer that causes patches of abnormal tissue to grow under the skin, in the lining of the mouth, nose, and throat or in other organs. the patches are usually red or purple and are made of cancer cells and blood cells. the red and purple patches often cause no symptoms, though they may be painful. if the cancer spreads to the digestive tract or lungs, bleeding can result. lung tumors can make breathing hard. before the hiv/aids epidemic, ks usually developed slowly. in hiv/aids patients, though, the disease moves quickly. treatment depends on where the lesions are and how bad they are. treatment for hiv itself can shrink the lesions. however, treating ks does not improve survival from hiv/aids itself. nih: national cancer institute

MalaCards: Kaposi's Sarcoma, also known as kaposi sarcoma, is related to sarcoma and acquired immunodeficiency syndrome, and has symptoms including anaemia, platelet disorders/thrombopathies and thrombocytopenia/thrombopenia. An important gene associated with Kaposi's Sarcoma is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Signaling by VEGF and Signaling by FGFR3 mutants. The drugs etoposide and interferon alfa-2a and the compounds pegasys and azd 2171 have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and lymph node, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:8 A connective tissue cancer that derives from lymphatic endothelium, and derives from spindle cells, results in formation of vascular channels that fill with blood cells, has material basis in human herpesvirus 8 (hhv8).

Description from OMIM:47 148000

Aliases & Classifications for Kaposi's Sarcoma

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Sources:
8Disease Ontology, 49Orphanet, 34MedlinePlus, 62UMLS, 47OMIM, 45Novoseek, 9diseasecard, 10DISEASES, 27ICD9CM, 58SNOMED-CT, 40NCIt, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

49
angiofollicular ganglionic hyperplasia:
Inheritance: Sporadic; Age of onset: Variable
kaposi's sarcoma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

kaposi's sarcoma 8 49 34
kaposi sarcoma 8 47 45 62
kaposi's sarcoma of conjunctiva 8 62
kaposi's sarcoma of soft tissue 8 62
kaposi's sarcoma of lymph nodes 8 62
gallbladder kaposi's sarcoma 8 62
kaposi's sarcoma of cornea 8 62
kaposi's sarcoma of palate 8 62
gastric kaposi's sarcoma 8 62
cardiac kaposi's sarcoma 8 62
kaposi sarcoma of the central nervous system 62
kaposi's sarcoma of gastrointestinal sites 8
kaposi's sarcoma of central nervous system 8
multicentric giant lymph node hyperplasia 49
central nervous system kaposi's sarcoma 8
angiofollicular ganglionic hyperplasia 49
kaposi's sarcoma of the gallbladder 8
kaposi sarcoma, susceptibility to 9
lymphadenopathic kaposi's sarcoma 8
angiofollicular lymph hyperplasia 49
kaposi's sarcoma of soft tissues 8
kaposi's sarcoma of the prostate 8
multicentric castleman disease 49
kaposi's sarcoma of esophagus 8
conjunctival kaposi's sarcoma 8
soft tissue kaposi's sarcoma 8
esophageal kaposi's sarcoma 8
intestinal kaposi's sarcoma 8
lymph node kaposi's sarcoma 8
kaposi's sarcoma of the cns 8
cutaneous kaposi's sarcoma 8
pulmonary kaposi's sarcoma 8
kaposi's sarcoma of heart 8
prostate kaposi's sarcoma 8
kaposi's sarcoma of penis 8
kaposi's sarcoma of lung 8
kaposi's sarcoma of skin 8
kaposi's sarcoma of anus 8
corneal kaposi's sarcoma 8
palate kaposi's sarcoma 8
penis kaposi's sarcoma 8
kaposi's sarcoma, skin 8
kaposi's sarcoma, lung 8
anal kaposi's sarcoma 8
castleman disease 49
kaposis sarcoma 10
mcd 49


External Ids:

Disease Ontology8 DOID:8632
ICD9CM27 176, 176.9
NCIt40 C9087
OMIM47 148000
MESH via Orphanet36 C536362, D005871, D012514 C537372, more
ICD10 via Orphanet26 D36.0, C46.1, C46.2 C46.3, C46.0, C46.8, C46.9, C46.7, more
SNOMED-CT via Orphanet59 207036003, 238809002, 109385007 49937004, more
UMLS via Orphanet63 C0017531, C2931179, C0036220 C1334815, more

Related Diseases for Kaposi's Sarcoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Kaposi's Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 202)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma32.0CD34, TAT, FLT4, OSM
2acquired immunodeficiency syndrome31.1IFNA1, IL6, TAT
3castleman's disease30.7IL6, IL6R
4pyogenic granuloma30.6FLT4, LYVE1, CD34
5angiosarcoma30.6CD34, FLT4
6hemangioma30.4VEGFA, FLT4, LYVE1, IFNA2, CD34, FGF4
7hepatitis30.4IFNA1, IFNA2, HGF, TAT
8leukopenia30.3IL6, IFNA2, IFNA1
9lymphangioma30.3CD34, LYVE1, FLT4
10hepatitis c30.3IFNA1, IFNA2, IL6R
11arthritis30.3OSM, IL6
12lymphedema30.2LYVE1, FLT4
13rheumatoid arthritis30.2IL6R, IL6, IL6ST, OSM, VEGFA
14deficiency anemia30.2IFNA1, IFNA2, IL6, TAT, CD34
15poems syndrome30.2VEGFA, IL6
16leukemia30.1OSM, FLT4, IFNA1, IFNA2, IL6ST, IL6
17meningioma30.1CD34
18plasmacytoma30.0OSM, IL6ST, IL6, IL6R
19myeloma29.8VEGFA, OSM, IFNA1, IFNA2, IL6ST, IL6
20classic kaposi sarcoma11.0
21endemic kaposi sarcoma10.6
22primary effusion lymphoma10.6
23endotheliitis10.5
24angiofollicular lymph hyperplasia10.5
25pemphigus10.3
26localized castleman disease10.3
27colon kaposi sarcoma10.3
28secondary syphilis10.3
29syphilis10.3
30hiv/aids10.3
31paraneoplastic pemphigus10.3
32malonyl-coa decarboxylase deficiency10.3
33cryptococcosis10.2
34gingivitis10.2
35non-hodgkin lymphoma10.2
36tuberculosis10.2
37virus associated hemophagocytic syndrome10.2
38polyarteritis nodosa10.1IFNA2
39crohn disease-associated growth failure10.1IL6
40lymphomatoid granulomatosis10.1IFNA2
41focal segmental glomerulosclerosis10.1
42multiple carboxylase deficiency10.1
43nephrotic syndrome10.1
44panuveitis10.1IFNA2
45capillary hemangioma10.1CD34
46central retinal vein occlusion10.1VEGFA
47fibrous histiocytoma10.1CD34
48cryoglobulinemic vasculitis10.1IFNA2, IFNA1
49hydrocele10.1FLT4
50diabetic macular edema10.1VEGFA

Graphical network of the top 20 diseases related to Kaposi's Sarcoma:



Diseases related to kaposi's sarcoma

Symptoms for Kaposi's Sarcoma

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47OMIM, 49Orphanet
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Symptoms by clinical synopsis from OMIM:

148000

Clinical features from OMIM:

148000

Symptoms:

49 (show all 35)
  • anaemia
  • platelet disorders/thrombopathies
  • thrombocytopenia/thrombopenia
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • asthenia/fatigue/weakness
  • tapered fingers
  • monoclonal immunoglobulins/gammapathy/dysglobulinemia
  • arthritis/synovitis/synovial proliferation
  • capillary hemangioma/nevus/naevus flammeus/port-wine stain
  • purpura/petichiae
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • cutaneous edema
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • cutaneous rash
  • gynecomastia/breast/mammary gland enlargement/hyperplasia
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • thoracic/chest pain
  • acute abdominal pain/colic
  • splenomegaly
  • hirsutism/hypertrichosis/increased body hair
  • ascitis
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • peripheral neuropathy
  • precocious menopause/secondary amenorrhea
  • diabetes mellitus
  • hypothyroidy
  • impotence/painful erection/priapism/erection troubles
  • proteinuria
  • renal failure
  • interstitial nephropathy
  • renal glomerular defect/glomerulopathy
  • lymphedema
  • lymphadenopathy/polyadenopathies
  • hepatomegaly/liver enlargement (excluding storage disease)

Drugs & Therapeutics for Kaposi's Sarcoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Kaposi's Sarcoma

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Anatomical Context for Kaposi's Sarcoma

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33MalaCards
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MalaCards organs/tissues related to Kaposi's Sarcoma:

33
Lung, Skin, Lymph node, Endothelial, Prostate, Heart, Liver, B cells, T cells, Breast, Bone, Colon, Monocytes, Kidney, Bone marrow, Brain, Tongue, Myeloid, Spleen, Nk cells

Animal Models for Kaposi's Sarcoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Kaposi's Sarcoma:

37 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.8VEGFA, IL6ST, IL6, IL6R, CD34, SLC7A11
2MP:00053709.7VEGFA, FLT4, IL6ST, IL6, IL6R, HGF
3MP:00053859.4CYSLTR2, VEGFA, FLT4, LYVE1, STIM1, IL6ST
4MP:00053789.4FLT4, STIM1, IL6ST, IL6, IL6R, HGF
5MP:00028739.4VEGFA, FLT4, CCR8, IL6ST, IL6R, FGF4
6MP:00053909.3VEGFA, STIM1, IL6ST, IL6, FGF4, FGF3
7MP:00053979.3VEGFA, LYVE1, STIM1, IL6ST, IL6, IL6R
8MP:00053849.3VEGFA, LYVE1, STIM1, IL6ST, IL6, IL6R
9MP:00107719.1FGF5, CYSLTR2, VEGFA, OSM, FLT4, STIM1
10MP:00107689.1VEGFA, FLT4, STIM1, CCNK, IL6ST, IL6
11MP:00053769.0CYSLTR2, VEGFA, FLT4, STIM1, IL6ST, IL6
12MP:00053878.9CYSLTR2, VEGFA, FLT4, LYVE1, STIM1, CCR8

Publications for Kaposi's Sarcoma

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52PubMed
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Articles related to Kaposi's Sarcoma:

(show top 50)    (show all 1058)
idTitleAuthorsYear
1
Mathematical Modeling of the HIV/Kaposi's Sarcoma Coinfection Dynamics in Areas of High HIV Prevalence. (24348744)
2013
2
Epigenetic diversity of Kaposi's sarcoma-associated herpesvirus. (23361465)
2013
3
Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins down regulate both DC-SIGN and DC-SIGNR. (23460925)
2013
4
The viral interferon regulatory factors of kaposi's sarcoma-associated herpesvirus differ in their inhibition of interferon activation mediated by toll-like receptor 3. (23115281)
2013
5
Bilateral auricular classic Kaposi's sarcoma. (24014559)
2013
6
Myasthenia gravis developing in an HIV-negative patient with Kaposi's sarcoma. (23010878)
2013
7
Association of Kaposi's sarcoma-associated herpesvirus (KSHV) with bladder cancer in Croatian patients. (23959475)
2013
8
Kaposi's sarcoma: a computational approach through protein-protein interaction and gene regulatory networks analysis. (23266878)
2013
9
Development of whole-virus multiplex luminex-based serological assays for diagnosis of infections with kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 homologs in macaques. (23345584)
2013
10
A candidate gene approach for virally induced cancer with application to HIV-related Kaposi's sarcoma. (23818101)
2013
11
False-Negative Results of Endoscopic Biopsy in the Diagnosis of Gastrointestinal Kaposi's Sarcoma in HIV-Infected Patients. (23227427)
2012
12
Phase II study of bevacizumab in patients with HIV-associated Kaposi's sarcoma receiving antiretroviral therapy. (22430271)
2012
13
Impact of antiretroviral therapy on the incidence of Kaposi's sarcoma in resource-rich and resource-limited settings. (22729153)
2012
14
Geographical patterns of Kaposi's sarcoma, nonHodgkin lymphomas, and cervical cancer associated with HIV infection in five African populations. (21955799)
2012
15
Uncommon diagnosis of oral Kaposi's sarcoma in an elderly human immunodeficiency virus-seronegative adult. (22690990)
2012
16
Kaposi's sarcoma in an atopic dermatitis patient: a case report and a review of literature. (21385206)
2011
17
Histone demethylase JMJD2A regulates Kaposi's sarcoma-associated herpesvirus replication and is targeted by a viral transcriptional factor. (21228229)
2011
18
Classic Kaposi's sarcoma in Arabs--widening ethnic involvement. (21546753)
2011
19
Mutational analysis of the latency-associated nuclear antigen DNA-binding domain of Kaposi's sarcoma-associated herpesvirus reveals structural conservation among gammaherpesvirus origin-binding proteins. (20484563)
2010
20
Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. (19939918)
2010
21
Localisation of Mediterranean Kaposi's sarcoma in Morgagni's ventricle. (21302693)
2010
22
Coexistent Kaposi's sarcoma and atypical mycobacterial infection involving lymph node: a case report and review of literature. (21045424)
2010
23
Activation of Akt through gp130 receptor signaling is required for Kaposi's sarcoma-associated herpesvirus-induced lymphatic reprogramming of endothelial cells. (18579585)
2008
24
Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression. (17652396)
2007
25
Intracellular Tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus: role of JAK/STAT signaling. (17151125)
2007
26
The insulin receptor is essential for virus-induced tumorigenesis of Kaposi's sarcoma. (17001305)
2007
27
Identification and characterization of the Orf49 protein of Kaposi's sarcoma-associated herpesvirus. (16501115)
2006
28
Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus. (16585191)
2006
29
Apoptotic effect of ganciclovir on primary effusion lymphoma cells infected with Kaposi's sarcoma-associated herpesvirus. (16838851)
2006
30
RhoA-GTPase facilitates entry of Kaposi's sarcoma-associated herpesvirus into adherent target cells in a Src-dependent manner. (17005646)
2006
31
Activation of mitogen-activated protein kinase and NF-kappaB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane protein. (12915550)
2003
32
Immune activation in AIDS related Kaposi's sarcoma]. (12734931)
2003
33
Human herpesvirus 8-associated primary effusion lymphoma in HIV--patients: a clinicopidemiologic variant resembling classic Kaposi's sarcoma. (11940475)
2002
34
Kaposi's sarcoma-associated herpesvirus LANA2 is a B-cell-specific latent viral protein that inhibits p53. (11119611)
2001
35
Immunomodulatory treatment with low-dose interferon-alpha and oral retinoic acid in lymphangioma-like Kaposi's sarcoma. (10769722)
2000
36
Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) open reading frame 36 protein is a serine protein kinase. (10725434)
2000
37
FGF4 and INT2 oncogenes are amplified and expressed in Kaposi's sarcoma. (10786811)
2000
38
The role of vascular endothelial growth factor (VEGF) in AIDS-related Kaposi's sarcoma. (10804088)
2000
39
Kaposi's sarcoma-associated herpesvirus open reading frame 50/Rta protein activates the entire viral lytic cycle in the HH-B2 primary effusion lymphoma cell line. (10846108)
2000
40
Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas. (10697276)
2000
41
Dihydrofolate reductase from Kaposi's sarcoma-associated herpesvirus. (10683342)
2000
42
Absence of Fas (CD95) and FasL (CD95L) immunohistochemical expression suggests Fas/FasL-mediated apoptotic signal is not relevant in cutaneous Kaposi's sarcoma lesions. (10563496)
1999
43
Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. (10196314)
1999
44
Human interferon-gamma-inducible protein 10 (IP-10) inhibits constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. (9670053)
1998
45
Fibronectin modulates the effects of HIV-1 Tat on the growth of murine Kaposi's sarcoma-like cells through the down-regulation of tyrosine phosphorylation. (9626063)
1998
46
Expression of adhesion molecules in endemic and epidemic Kaposi's sarcoma. (8910041)
1996
47
Expression of transforming growth factor beta and transforming growth factor beta receptors on AIDS-associated Kaposi's sarcoma. (9815902)
1995
48
Possible role of granulocyte-macrophage colony stimulating factor (GM-CSF) on the rapid progression of AIDS-related Kaposi's sarcoma lesions in vivo. (7947290)
1994
49
Histiocytoid hemangioma with features of angiolymphoid hyperplasia and Kaposi's sarcoma. A study by light microscopy, electron microscopy, and immunologic techniques. (6230021)
1983
50
Kaposi's sarcoma and parapsoriasis en plaque in brothers. (5066910)
1972

Variations for Kaposi's Sarcoma

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Expression for genes affiliated with Kaposi's Sarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Kaposi's Sarcoma

Search GEO for disease gene expression data for Kaposi's Sarcoma.

Pathways for genes affiliated with Kaposi's Sarcoma

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 54R&D Systems, 60Thomson Reuters
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Pathways related to Kaposi's Sarcoma according to GeneCards/GeneDecks:

(show all 49)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.2FLT4, VEGFA
2
Show member pathways
10.1FGF4, FGF5
310.1IL6R, IL6, VEGFA
410.1VEGFA, IL6, IL6R
5
Show member pathways
10.0IL6, IFNA2, IFNA1
610.0IL6, IFNA2, IFNA1
710.0IFNA1, IFNA2, IL6
810.0IFNA1, IFNA2, IL6
9
Show member pathways
10.0IL6ST, IL6, IL6R
1010.0IL6ST, IL6, IL6R
1110.0IL6R, IL6, IL6ST
12
Show member pathways
10.0IL6R, IL6, IL6ST
13
Show member pathways
10.0IL6R, IL6, IL6ST
1410.0IL6ST, IL6, IL6R
1510.0IL6R, IL6, IL6ST
16
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
10.0IL6ST, IL6, IL6R
1710.0IL6, IL6R, CD34
1810.0OSM, IL6ST, IL6
1910.0VEGFA, OSM, IL6ST
20
Show member pathways
10.0FGF5, FGF3, FGF4
21
Show member pathways
10.0FGF5, FGF3, FGF4
22
Show member pathways
10.0FGF4, FGF3, FGF5
23
Show member pathways
9.9HGF, IL6R, IL6, IL6ST
24
Show member pathways
9.8STIM1, FGF4, FGF3, FGF5
25
Show member pathways
9.8FGF5, FGF3, FGF4, CYSLTR2
26
Show member pathways
9.8FGF5, FGF3, FGF4, FLT4
27
Show member pathways
9.7FLT4, IL6, HGF, FGF4, FGF5
28
Show member pathways
9.7FLT4, IL6, HGF, FGF4, FGF5
29
Show member pathways
9.7FLT4, IL6, HGF, FGF4, FGF5
30
Show member pathways
9.7FLT4, IL6, HGF, FGF4, FGF5
31
Show member pathways
9.7FGF4, HGF, IL6, FLT4, FGF5
32
Show member pathways
9.7FLT4, IL6, HGF, FGF4, FGF5
33
Show member pathways
Signaling Pathways in Glioblastoma38
9.7VEGFA, HGF, FGF4, FGF3, FGF5
349.7VEGFA, HGF, FGF4, FGF3, FGF5
35
Show member pathways
9.6STIM1, CD34, FGF4, FGF3, FGF5
36
Show member pathways
9.6VEGFA, STIM1, IFNA1, IFNA2, HGF, SLC7A11
37
Show member pathways
9.6IFNA1, IFNA2, IL6ST, IL6, IL6R, HGF
389.6VEGFA, IL6, HGF, FGF4, FGF3, FGF5
39
Show member pathways
9.6FLT4, IL6, HGF, FGF4, FGF3, FGF5
40
Show member pathways
9.5VEGFA, FLT4, HGF, FGF4, FGF3, FGF5
41
Show member pathways
Type III interferon signaling38
9.5OSM, IFNA1, IFNA2, IL6ST, IL6, IL6R
42
Show member pathways
9.5FLT4, IL6ST, IL6, HGF, FGF4, FGF5
43
Show member pathways
9.3CYSLTR2, VEGFA, FLT4, CCR8, FGF4, FGF3
44
Show member pathways
9.2OSM, FGF5, FGF4, HGF, IL6R, IL6
45
Show member pathways
9.2FGF4, HGF, IL6R, IL6, CCR8, FLT4
46
Show member pathways
9.2OSM, FLT4, CCR8, IL6, IL6R, HGF
47
Show member pathways
9.1FLT4, IFNA1, IFNA2, IL6, IL6R, HGF
48
Show member pathways
8.9CCR8, FLT4, OSM, VEGFA, IFNA1, IFNA2
498.8FGF5, VEGFA, OSM, FLT4, IFNA1, IFNA2

Compounds for genes affiliated with Kaposi's Sarcoma

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Sources:
45Novoseek, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Kaposi's Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1pegasys4510.4IFNA1, IFNA2
2azd 21714510.4VEGFA, FLT4
3filgrastim45 1111.4HGF, IL6, IFNA2, OSM
4temozolomide45 1111.4IFNA2, VEGFA, IFNA1
5imiquimod45 61 29 1113.4IL6, IFNA2, IFNA1
6isotretinoin45 1111.3IFNA2, HGF, IFNA1
7sunitinib45 51 1112.3IFNA1, VEGFA, FLT4
82,5-oligoadenylate4510.3TAT, IFNA1, IFNA2, IL6
9tocilizumab45 1111.3IL6, IL6R
10neopterin4510.3IL6R, IFNA2, IFNA1, IL6
11entecavir4510.3IFNA2, IFNA1
12rituximab45 51 1112.3IFNA1, IL6R, IFNA2, IL6
13suramin45 29 1112.3FGF4, IL6R, HGF, VEGFA
14ccl345 2911.2IL6, TAT, IFNA1, CCR8
15neomycin4510.2TAT, FGF4, HGF, LYVE1
16gp 1304510.2IL6R, IL6, IL6ST, OSM
17ursodeoxycholic acid45 24 1112.2IFNA2, IFNA1, HGF
18tgf beta14510.2HGF, OSM, FGF4, IL6
19indomethacin45 29 61 1113.2OSM, IFNA2, IL6, HGF, TAT
20acth4510.1IL6ST, IL6, IFNA2, OSM, CYSLTR2
21cyclophosphamide45 51 1112.1HGF, IFNA2, IFNA1, VEGFA
22infliximab45 51 1112.1VEGFA, IFNA2, IL6
23hyaluronic acid45 2411.1IL6, HGF, VEGFA, LYVE1, OSM
24matrigel4510.1HGF, FLT4, OSM, VEGFA, FGF4
25thalidomide45 51 61 1113.1VEGFA, IFNA2, IL6, IL6R, HGF, IFNA1
26actinomycin d4510.1IL6, TAT, HGF, IFNA1, VEGFA
27leucovorin45 51 1112.0IFNA2, IFNA1, VEGFA
28genistein45 29 61 3 24 1115.0VEGFA, IL6, HGF, TAT, OSM, IL6ST
29ifn-alpha4510.0IFNA2, IFNA1, OSM, IL6ST, IL6R, IL6
30cyclosporin a45 29 6111.9IL6R, IFNA1, IL6, TAT, HGF
31histamine45 29 2411.9IL6R, OSM, HGF, IFNA2, IL6, TAT
32estradiol45 24 1111.9OSM, LYVE1, IL6R, HGF, TAT
33rantes459.9TAT, IL6R, CCR8, OSM, IFNA1, IL6
34prednisolone45 29 1111.9TAT, IL6R, IL6, IL6ST, HGF, IFNA2
35sorafenib45 51 1111.9FLT4, IFNA1, VEGFA
36paraffin459.9LYVE1, CD34, FLT4, VEGFA, HGF
37pge2459.9VEGFA, CYSLTR2, IL6R, IL6, OSM, IL6ST
38heparin45 29 24 1112.8HGF, CYSLTR2, FGF5, FGF3, FGF4, VEGFA
39oxygen45 2410.8SLC7A11, FLT4, CYSLTR2, IFNA2, FGF4, TAT
40cycloheximide459.7VEGFA, TAT, HGF, IL6R, IL6, IL6ST
41lipid459.7IFNA2, TAT, HGF, IL6R, IL6, IL6ST
42agar459.7FGF3, OSM, IFNA2, HGF, TAT, CD34
43methotrexate51 45 1111.7TAT, IL6R, IL6, HGF
44alanine459.6IL6, HGF, IL6ST, IFNA2, TAT, IFNA1
45dexamethasone45 51 29 1112.6IL6ST, HGF, IL6R, OSM, VEGFA, IL6
46thymidine45 2410.4IL6R, FGF5, CD34, OSM, LYVE1, IFNA1
47retinoic acid45 2410.2IL6, IL6ST, IFNA2, IFNA1, FLT4, OSM
48estrogen459.2VEGFA, IL6ST, IFNA2, LYVE1, FLT4, OSM
49tyrosine458.7CYSLTR2, VEGFA, FGF4, OSM, FLT4, IFNA1
50vegf458.4FLT4, CD34, TAT, HGF, IL6R, IL6

GO Terms for genes affiliated with Kaposi's Sarcoma

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Sources:
16Gene Ontology
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Cellular components related to Kaposi's Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oncostatin-M receptor complexGO:00590010.1IL6ST, OSM
2interleukin-6 receptor complexGO:0058969.9IL6ST, IL6, IL6R
3extracellular regionGO:0055769.0FGF5, VEGFA, FLT4, IFNA2, IL6ST, IL6
4extracellular spaceGO:0056159.0VEGFA, OSM, IFNA2, IL6ST, IL6, IL6R

Biological processes related to Kaposi's Sarcoma according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1hepatic immune responseGO:00238410.6IL6R, IL6
2negative regulation of collagen biosynthetic processGO:03296610.6IL6R, IL6
3neutrophil mediated immunityGO:00244610.5IL6R, IL6
4positive regulation of protein kinase C signalingGO:09003710.5VEGFA, FLT4
5ciliary neurotrophic factor-mediated signaling pathwayGO:07012010.5IL6ST, IL6R
6positive regulation of leukocyte chemotaxisGO:00269010.5IL6, IL6R
7negative regulation of neuron deathGO:190121510.5CD34, IL6
8negative regulation of hormone secretionGO:04688810.5OSM, IL6
9negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04315410.5HGF, IL6, VEGFA
10interleukin-6-mediated signaling pathwayGO:07010210.4IL6ST, IL6, IL6R
11positive regulation of chemokine productionGO:03272210.4IL6, IL6R
12monocyte chemotaxisGO:00254810.4IL6R, IL6
13positive regulation of peptidyl-serine phosphorylationGO:03313810.4IL6, OSM, VEGFA
14glutamate metabolic processGO:00653610.4TAT, CD34
15positive regulation of acute inflammatory responseGO:00267510.4IL6, IL6ST, OSM
16cellular response to vascular endothelial growth factor stimulusGO:03592410.3VEGFA, FLT4
17positive regulation of angiogenesisGO:04576610.3CD34, VEGFA, CYSLTR2
18positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.3IL6R, IL6, IL6ST, IFNA2
19positive regulation of osteoblast differentiationGO:04566910.3IL6ST, IL6, IL6R, HGF
20positive regulation of protein phosphorylationGO:00193410.3FGF4, FLT4, VEGFA
21positive regulation of ERK1 and ERK2 cascadeGO:07037410.3CYSLTR2, FLT4, IL6, FGF4
22positive regulation of MAPK cascadeGO:04341010.3IL6R, IL6, FLT4, OSM
23positive regulation vascular endothelial growth factor productionGO:01057510.3IL6ST, FLT4
24cytokine-mediated signaling pathwayGO:01922110.3IFNA2, IL6ST, IL6, IL6R
25defense response to Gram-negative bacteriumGO:05082910.2IL6R, IL6
26vascular endothelial growth factor receptor signaling pathwayGO:04801010.2VEGFA, FLT4
27positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.2VEGFA, OSM, IL6, IL6R, HGF
28blood coagulationGO:00759610.2VEGFA, STIM1, IFNA2, HGF, SLC7A11
29cell-cell signalingGO:00726710.2FGF5, FGF3, FGF4, IFNA2
30phosphatidylinositol-mediated signalingGO:04801510.1FGF5, FGF3, FGF4
31positive regulation of cell divisionGO:05178110.1VEGFA, OSM, FGF4, FGF3, FGF5
32insulin receptor signaling pathwayGO:00828610.0FGF5, FGF3, FGF4
33positive regulation of transcription from RNA polymerase II promoterGO:04594410.0FGF4, HGF, IL6, OSM, VEGFA
34negative regulation of apoptotic processGO:04306610.0VEGFA, FLT4, IL6ST, IL6, HGF, FGF4
35fibroblast growth factor receptor signaling pathwayGO:0085439.9FGF5, FGF3, FGF4
36hyaluronan metabolic processGO:0302129.8HGF, LYVE1
37positive regulation of cell proliferationGO:0082849.5FGF5, VEGFA, OSM, FLT4, IL6ST, IL6

Molecular functions related to Kaposi's Sarcoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1interleukin-6 bindingGO:01998110.3IL6ST, IL6R
2chemoattractant activityGO:04205610.2HGF, VEGFA
3interleukin-6 receptor activityGO:00491510.2IL6ST, IL6R
4interleukin-6 receptor bindingGO:00513810.2IL6ST, IL6, IL6R
5fibroblast growth factor receptor bindingGO:00510410.1FGF5, FGF3, FGF4
6ciliary neurotrophic factor receptor activityGO:00489710.1IL6R, IL6ST
7cytokine activityGO:0051259.9VEGFA, OSM, IFNA2, IL6
8growth factor activityGO:0080839.6FGF5, FGF3, FGF4, HGF, IL6, OSM
9protein bindingGO:0055158.6VEGFA, FLT4, STIM1, CCNK, IFNA2, IL6ST

Products for genes affiliated with Kaposi's Sarcoma

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  • Antibodies
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Sources for Kaposi's Sarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet