KD
MCID: KWS002
MIFTS: 69

Kawasaki Disease (KD) malady

Nephrological, Bone, Immune categories

Summaries for Kawasaki Disease

Sources:
43NIH Rare Diseases, 34MedlinePlus, 21Genetics Home Reference, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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MedlinePlus:34 Kawasaki disease is a rare childhood disease. it makes the walls of the blood vessels in the body become inflamed. it can affect any type of blood vessel, including the arteries, veins, and capillaries. no one knows what causes kawasaki disease. symptoms include high fever that lasts longer than 5 days swollen lymph nodes in the neck a rash on the mid-section and genital area red, dry, cracked lips and a red, swollen tongue red, swollen palms of the hands and soles of the feet redness of the eyes kawasaki disease can't be passed from one child to another. there is no single test. to diagnose it, doctors look at the signs and symptoms. they may also use an echocardiogram or other tests. it is mainly treated with medicines. rarely, medical procedures and surgery also may be used for children whose coronary arteries are affected. kawasaki disease can't be prevented. however, most children who develop the disease fully recover - usually within weeks of getting signs and symptoms. further problems are rare. nih: national heart, lung, and blood institute

MalaCards: Kawasaki Disease, also known as mucocutaneous lymph node syndrome, is related to coronary artery disease, and aneurysm disease, and has symptoms including nausea/vomiting/regurgitation/merycism/hyperemesis, ptosis and humour troubles/anxiety/depression/apathy/euphoria/irritability. An important gene associated with Kawasaki Disease is ITPKC (inositol-trisphosphate 3-kinase C), and among its related pathways are Cell adhesion Cell-matrix glycoconjugates and Cell adhesion ECM remodeling. The compounds lactate and creatinine have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and tongue, and related mouse phenotypes are immune system and homeostasis/metabolism.

NIH Rare Diseases:43 Kawasaki syndrome is a condition that involves inflammation of the blood vessels. it is typically diagnosed in young children, but older children and adults can also develop this condition.  kawasaki syndrome is usually accompanied by a fever that lasts at least 5 days. other classic symptoms may include red eyes, lips, and mouth; rash; swollen and red hands and feet; and swollen lymph nodes. kawasaki syndrome occurs most often in people of asian and pacific island descent. last updated: 1/12/2009

Genetics Home Reference:21 Kawasaki disease is a sudden and time-limited (acute) illness that affects infants and young children. Affected children develop a prolonged fever lasting several days, a skin rash, and swollen lymph nodes in the neck (cervical lymphadenopathy). They also develop redness in the whites of the eyes (conjunctivitis) and redness (erythema) of the lips, lining of the mouth (oral mucosa), tongue, palms of the hands, and soles of the feet.

Wikipedia:64 Kawasaki disease, also known as Kawasaki syndrome, lymph node syndrome and mucocutaneous lymph node... more...

Description from OMIM:47 611775

Aliases & Classifications for Kawasaki Disease

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 61UMLS, 35MeSH, 57SNOMED-CT, 27ICD9CM, 40NCIt, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological, Bone, Immune


Characteristics (Orphanet epidemiological data):

49
kawasaki disease:
Inheritance: Sporadic; Age of onset: Neonatal/infancy


Aliases & Descriptions:

kawasaki disease 8 43 21 47 10 45 49 34
mucocutaneous lymph node syndrome 8 43 21 49 61
acute febrile mucocutaneous lymph node syndrome 8 21
kawasaki syndrome 43 21
acute febrile mucocutaneous lymph node syndrome nos 8
kawasaki disease, susceptibility to 9
kawasaki's disease 8
acute febrile mcls 8
mlns 8
kd 21


External Ids:

Disease Ontology8 DOID:13378
MeSH35 D009080
OMIM47 611775
ICD9CM27 446.1
NCIt40 C34825
ICD10 via Orphanet26 M30.3
ICD1025 M30.3

Related Diseases for Kawasaki Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Kawasaki Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 359)
idRelated DiseaseScoreTop Affiliating Genes
1coronary artery disease,31.6HSPD1, SELE, MMP9, MMP3, CRP, NPPB
2aneurysm disease31.5MMP3, MMP9, SELL, ELANE
3vascular disease30.9HSPD1, CCL2, CRP, MMP9, SELE, ELANE
4rheumatic disease30.7CRP
5rheumatic fever30.7MBL2, CRP
6arthritis30.6TIMP1, MMP3, SELL
7vasculitis30.5HSPD1, CCL2, S100A12, MBL2, CRP, ITPKC
8acute myocardial infarction30.4CRP, MMP9, SELE, ADM, NPPB
9uveitis30.4CCL2, HSPD1
10atherosclerosis30.3MYD88, MMP3, MMP9, SELL, SELE, ELANE
11hepatitis c30.3GPT, CIITA, TIMP1
12systemic lupus erythematosus30.3HSPD1, CCL2, MBL2, CRP, CIITA, MMP3
13coronary heart disease30.3HSPD1, NPPB, CRP, SELE
14aortic aneurysm30.3CRP
15toxic shock syndrome30.2CIITA
16measles30.2CIITA
17ulcerative colitis30.1CRP, MMP3, SELL, SELE, ELANE
18cystic fibrosis30.1ELANE, MBL2
19thyroiditis30.1CIITA, MBL2
20celiac disease30.1CIITA
21asthma30.0TIMP1, CCL2, S100A12, MBL2, CIITA, MMP3
22atopic dermatitis30.0TIMP1, CCL2, FCER2, SELL, SELE
23acute pancreatitis29.9CRP, GPT, ELANE
24acute pyelonephritis29.9CRP
25acquired immunodeficiency syndrome29.9CCL3L1
26appendicitis29.9CRP
27tonsillitis29.9CRP
28graves' disease29.9SELE, SELL, CIITA
29alzheimer's disease29.9S100A12, ELANE
30sepsis29.8CIITA, MYD88, SELL, SELE, ADM, ELANE
31tuberculosis29.8HSPD1, MBL2, CRP, CIITA, MYD88, SELL
32adenocarcinoma29.8TIMP1, MMP9, SELL, ADM
33nephritis29.8CCL2
34pemphigus vulgaris29.8FCER2, CIITA
35coronary aneurysm11.0
36coronary artery aneurysm10.9
37brain disease10.5
38pyuria10.4
39hemophagocytic lymphohistiocytosis10.4
40coronary thrombosis10.3
41n syndrome10.3
42vein disease10.3
43hepatitis a10.3
44mantle cell lymphoma10.3
45x-linked spinal-bulbar muscle atrophy10.3
46spinal-bulbar muscular atrophy10.3
47hereditary leiomyomatosis and renal cell cancer10.3
48anterior uveitis10.3
49q fever10.3
50aortic disease10.3

Graphical network of the top 20 diseases related to Kawasaki Disease:



Diseases related to kawasaki disease

Clinical Features for Kawasaki Disease

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

611775

Symptoms:

49 (show all 40)
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • ptosis
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • dermal/subcutaneous infiltration/induration
  • arthritis/synovitis/synovial proliferation
  • proteinuria
  • asthenia/fatigue/weakness
  • cranial nerves palsy
  • fever/chilling
  • articular/joint pain/arthralgia
  • cardiac rhythm disorder/arrhythmia
  • hepatitis/icterus/cholestasis
  • dry/squaly skin/exfoliation
  • cutaneous rash
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • cutaneous edema
  • cardiac valvulopathy
  • heart/cardiac failure
  • oral mucosa disease/cheilitis
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • acute abdominal pain/colic
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • angor pectoris/myocardial infarction
  • myocardium anomalies/myocarditis
  • biliary/gallbladder stones/lithiasis/cholecystitis
  • facial pain/cephalalgia/migraine
  • aortic root dilatation/dilation/aneurysm
  • pharyngitis
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • vascularitis/vasculitides/arteritis
  • meningitis/meningeal syndrome
  • lymphadenopathy/polyadenopathies
  • acute diarrhea
  • enanthema/aphtosa/aphta/leukoplakia
  • hyperleukocytosis/leukocytosis
  • glossitis
  • acute ischemic syndrome
  • abnormal nails colour/leukonychia/melanonychia
  • aseptic leukocyturia

Drugs & Therapeutics for Kawasaki Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Kawasaki Disease

Drug clinical trials:

Search ClinicalTrials for Kawasaki Disease

Search NIH Clinical Center for Kawasaki Disease

Search CenterWatch for Kawasaki Disease

Genetic Tests for Kawasaki Disease

Anatomical Context for Kawasaki Disease

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Kawasaki Disease:

33
Skin, Liver, Tongue, Brain, Kidney, Lymph node, Lung, Whole blood, Heart, Small intestine, Tonsil, Myeloid, Monocytes, T cells, B cells, Endothelial

Animal Models for Kawasaki Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Kawasaki Disease

Sources:
51PubMed
See all sources

Articles related to Kawasaki Disease:

(show top 50)    (show all 895)
idTitleAuthorsYear
1
The Late Sequalae of Coronary Artery in A Grown Up Kawasaki Disease Patient. (23629576)
2013
2
Frequency-domain optical coherence tomography evaluation of a patient with Kawasaki disease and severely calcified plaque. (24365617)
2013
3
N-terminal pro-brain natriuretic Peptide as a useful diagnostic marker of acute Kawasaki disease in children. (23615024)
2013
4
Rare refractory kawasaki disease in an adolescent boy with cardiac and diffuse coronary artery involvement. (24375247)
2013
5
Coronary artery aneurysm after kawasaki disease in a single coronary artery. (23685733)
2013
6
The role of TNF-I+ in a murine model of Kawasaki disease arteritis induced with a Candida albicans cell wall polysaccharide. (23529573)
2013
7
Successful pregnancy and delivery in patient with artery bypass grafting for coronary lesion caused by Kawasaki disease. (23588640)
2013
8
Acute scrotum in Kawasaki disease: two case reports and a literature review. (24330284)
2013
9
Endothelial and Platelet Function in Children With Previous Kawasaki Disease. (24019084)
2013
10
Persistent coronary arterial inflammation in a patient long after the onset of Kawasaki disease. (22075420)
2012
11
Late coronary sequels of Kawasaki disease. (22634169)
2012
12
Lack of association between CLEC5A gene single-nucleotide polymorphisms and Kawasaki disease in Taiwanese children. (22536019)
2012
13
Kawasaki disease, what about seasonal variation? (22246611)
2012
14
Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial. (22405251)
2012
15
Histopathology of the longest-lived saphenous vein graft in a patient with Kawasaki disease. (22632509)
2012
16
Clinical relevance of the risk factors for coronary artery lesions in Kawasaki disease. (22226058)
2012
17
Incomplete Kawasaki disease with intermittent fever and retropharyngeal inflammation. (22189530)
2012
18
Altered central aortic elastic properties in Kawasaki disease are related to changes in left ventricular geometry and coronary artery aneurysm formation. (22494539)
2012
19
A novel anti-peroxiredoxin autoantibody in patients with Kawasaki disease. (22003971)
2012
20
Microparticles and Kawasaki disease: a marker of vascular damage? (21385556)
2011
21
Alteration of CD4CD25Foxp3 T cell level in Kawasaki disease. (21738549)
2011
22
Notch homolog 4 polymorphism and Kawasaki disease. (21203870)
2011
23
Evidence of acute Mycoplasma infection in a patient with incomplete and atypical kawasaki disease: a case report. (22203852)
2011
24
Increased plasma type B natriuretic peptide in the acute phase of Kawasaki disease. (21410593)
2011
25
Cardiac magnetic resonance imaging for noninvasive assessment of cardiovascular disease during the follow-up of patients with Kawasaki disease. (21921132)
2011
26
Identification of novel susceptibility Loci for kawasaki disease in a Han chinese population by a genome-wide association study. (21326860)
2011
27
Possible new role of vascular endothelial growth factor-D during the acute phase of Kawasaki disease. (21532175)
2011
28
Etanercept as adjunctive treatment for acute Kawasaki disease: study design and rationale. (21392603)
2011
29
Cytokine genetic polymorphisms and susceptibility to Kawasaki disease in Taiwanese children. (21048327)
2010
30
Altered immunoglobulin A and M levels associated with changes in BAFF and APRIL after administration of intravenous immunoglobulin to treat Kawasaki disease. (20945608)
2010
31
Association between polymorphisms of matrix metalloproteinase 11 (MMP-11) and Kawasaki disease in the Korean population. (20230842)
2010
32
Chikungunya mimicking atypical Kawasaki disease in an infant. (19935121)
2010
33
Usefulness of 64-slice MDCT for follow-up of young children with coronary artery aneurysm due to Kawasaki disease: initial experience. (18164157)
2009
34
Enhancement of activated beta1-integrin expression by prostaglandin E2 via EP receptors in isolated human coronary arterial endothelial cells: implication for the treatment of Kawasaki disease. (19169646)
2009
35
Association of mannose-binding lectin gene polymorphisms with Kawasaki disease in the Japanese. (20374367)
2009
36
Chronic granulomatous disease associated with atypical Kawasaki disease. (17676373)
2008
37
Kawasaki disease associated with reactive hemophagocytic lymphohistiocytosis. (18946363)
2008
38
Change of MyD88-independent signal transduction of Toll-like receptor 4 in immunological pathogenesis of Kawasaki disease]. (18282411)
2007
39
Vascular endothelial growth factor gene haplotypes in Kawasaki disease. (16645995)
2006
40
Polymorphism of matrix metalloproteinase-3 promoter gene as a risk factor for coronary artery lesions in Kawasaki disease. (16100452)
2005
41
Adrenomedullin is highly expressed in blood monocytes associated with acute Kawasaki disease: a microarray gene expression study. (15531734)
2005
42
Association of IL-1Ra gene polymorphism, but no association of IL-1beta and IL-4 gene polymorphisms, with Kawasaki disease. (15900570)
2005
43
CD8 T lymphocytes do not express cytotoxic proteins in coronary artery aneurysms in acute Kawasaki disease. (15818305)
2005
44
Sustained activation of neutrophils in the course of Kawasaki disease: an association with matrix metalloproteinases. (15958085)
2005
45
Correlation between mannose-binding lectin gene codon 54 polymorphism and susceptibility of Kawasaki disease]. (15144709)
2004
46
Images in cardiology. Coronary artery aneurysm in Kawasaki's disease. (11129680)
2000
47
Images in cardiovascular medicine. Giant coronary aneurysm of Kawasaki disease developing during postacute phase. (9665066)
1998
48
Increased levels of urinary interleukin-6 in Kawasaki disease. (8404968)
1993
49
Predictive factors of coronary aneurysm in Kawasaki disease--correlation between coronary arterial lesions and serum albumin, cholinesterase activity, prealbumin, retinol-binding protein and immature neutrophils. (3423065)
1987
50
Correlates of coronary artery aneurysm formation in patients with Kawasaki disease. (3812389)
1987

Genetic Variations for Kawasaki Disease

Expression for genes affiliated with Kawasaki Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Kawasaki Disease

Search GEO for disease gene expression data for Kawasaki Disease.

Pathways for genes affiliated with Kawasaki Disease

Sources:
12EMD Millipore, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 54Reactome
See all sources

Compounds for genes affiliated with Kawasaki Disease

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Kawasaki Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
1lactate4511.7CRP, MMP9, HSPD1, TIMP1, NPPB, SELL
2creatinine4511.6HSPD1, GPT, SELL, SELE, MBL2, ADM
3vegf4511.6TIMP1, CRP, MMP9, MMP3, SELE, NPPB
4lipid4511.5HSPD1, CRP, NPPB, CIITA, ADM, GPT
5cholesterol45 29 11 2414.5CRP, ADM, CCL2, GPT, SELE, MBL2
6alanine4511.5ADM, MMP3, HSPD1, TIMP1, CIITA, CRP
7sb 20358045 6012.5FCER2, MMP3, CRP, NPPB, SELL, SELE
8paraffin4511.5MBL2, MMP9, HSPD1, TIMP1, CCL2, ADM
9atorvastatin45 50 29 11 2415.4SELE, MMP9, CRP, SELL, CCL2, TIMP1
10cysteine4511.4ELANE, ADM, FCER2, HSPD1, TIMP1, MBL2
11simvastatin45 50 60 29 11 2416.4CRP, CCL2, MMP3, MMP9, GPT, SELL
12n acetylcysteine4511.4HSPD1, TIMP1, CCL2, CRP, MMP3, GPT
13fibrinogen4511.4GPT, MBL2, MMP9, CCL2, HSPD1, SELE
14histamine45 29 2413.4SELE, TIMP1, CCL2, NPPB, MMP3, FCER2
15genistein45 29 60 2 11 2416.3CCL2, TIMP1, MMP9, NPPB, MMP3, FCER2
16p0024511.3NPPB, TIMP1, GPT, ADM, MMP9, CRP
17glutamine4511.3MMP3, FCER2, GPT, TIMP1, ELANE, CCL2
18prostacyclin4511.3ELANE, CCL2, NPPB, CRP, ADM, TIMP1
19endotoxin4511.3ADM, HSPD1, SELE, SELL, MYD88, CIITA
20dexamethasone45 50 29 1114.3SELL, MMP9, CIITA, NPPB, TIMP1, FCER2
21serine4511.3CCL2, CIITA, FCER2, MMP3, MMP9, TIMP1
22oxygen45 2412.3MYD88, CCL2, CIITA, SELL, ADM, ELANE
23pioglitazone45 50 29 1114.2GPT, NPPB, CRP, CCL2, TIMP1, MMP9
24pravastatin45 50 29 11 2415.2CCL2, NPPB, CRP, MMP3, GPT, SELE
25cyclosporin a45 29 6013.2ADM, CIITA, GPT, ELANE, NPPB
268-isoprostane4511.2NPPB, CRP, MMP9, CCL2, SELE
27superoxide45 2412.2MBL2, ELANE, SELL, FCER2, HSPD1, CCL2
28nitric oxide45 11 2413.1SELE, MBL2, FCER2, CIITA, ADM, NPPB
29prednisolone45 29 1113.1SELL, MMP3, MBL2, NPPB, CRP
30batimastat45 60 1113.1MMP9, FCER2, TIMP1, ELANE, MMP3
31cytochalasin d45 6012.1TIMP1, SELE, SELL, MMP9, MMP3, CCL2
32vitamin d4511.1ELANE, TIMP1, CCL2, NPPB, MBL2, MMP3
33rantes4511.1SELL, MBL2, CIITA
34rosiglitazone45 50 29 11 2415.1TIMP1, GPT, NPPB
35cycloheximide4511.0SELL, HSPD1
36fenofibrate45 50 1113.0CCL2, MMP9, GPT, CRP, SELE
37herbimycin a45 6012.0MMP9, TIMP1, CCL2, FCER2, SELL, SELE
38norepinephrine45 11 2413.0ELANE, ADM
39aspartate4511.0GPT, CCL2, SELE, HSPD1, MBL2
40(4-aminophenyl)mercuric acetate4511.0ELANE, MMP9, MMP3, TIMP1
41pge24511.0MMP9
42glucose4511.0S100A12, NPPB, ADM
43gabexate mesilate4510.9MMP9, ELANE
44fluvastatin45 50 29 1113.9GPT, MMP9, CRP, SELE, CCL2
45isoproterenol45 1111.8CCL2, NPPB, ELANE, SELL, ADM, SELE
46cyclophosphamide45 50 1112.8NPPB, MBL2, CRP
47egcg4510.8ELANE
48doxycycline45 1111.8ELANE, TIMP1, MMP9, HSPD1, MMP3
49neopterin4510.7FCER2, MBL2, CRP, GPT, ELANE
50valsartan45 60 29 1113.4NPPB, CCL2, TIMP1, CRP

GO Terms for genes affiliated with Kawasaki Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Kawasaki Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.2CCL2, S100A12, MBL2, NPPB, CRP, MMP3
2extracellular spaceGO:00561510.8ADM, HSPD1, CCL2, MBL2, NPPB, CRP

Biological processes related to Kawasaki Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:02261710.9ELANE, MMP9, MMP3, TIMP1
2inflammatory responseGO:00695410.9SELE, MYD88, CRP, S100A12, CCL2
3agingGO:00756810.9TIMP1, CCL2, CRP, ADM
4defense response to Gram-positive bacteriumGO:05083010.7MBL2, CRP, MYD88
5extracellular matrix organizationGO:03019810.7ELANE, MMP9, MMP3, TIMP1
6opsonizationGO:00822810.6CRP, MBL2
7collagen catabolic processGO:03057410.6ELANE, MMP9, MMP3
8positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.3CCL2, FCER2

Molecular functions related to Kawasaki Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00510210.7ADM, NPPB, MBL2, CCL2

Products for genes affiliated with Kawasaki Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Kawasaki Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet