Keloids malady

Wikipedia: A keloid (pron.: /ˈkiːlɔɪd/; also keloidal scar) is a type of scar which, depending on its maturity,...⁴⁴ more...

MalaCards: Keloids, also known as keloid, is related to localized scleroderma and basal cell carcinoma. An important gene associated with Keloids is TKCR (torticollis, keloids, cryptorchidism and renal dysplasia), and among its related pathways are Breast Cancer Regulation by Stathmin1 and Colorectal cancer. The compounds glucose and ns 398 have been mentioned in the context of this disorder. Affiliated tissues include skin, b cells and endothelial, and related mouse phenotypes are respiratory system and craniofacial.

keloids 16 keloid 32

Diseases related to keloids by text searches and GeneDecks gene sharing:

(show top 50)    (show all 823)

id	Related Disease	Score	Top Affiliating Genes
1	localized scleroderma	30.8	CD36, MMP1, LOX, F13A1, DCN
2	basal cell carcinoma	28.2	CD44, ITGB1, MMP1, MMP13, F13A1, TP53
3	leiomyoma	22.0	PCNA, SERPINE1, VEGFA, VCAN, BMP6, JUN
4	hypoxia	16.3	PIK3CB, PIK3CG, PCNA, SERPINE1, VEGFA, BMP6
5	fibrosis	15.3	PIK3CG, PCNA, SERPINH1, SERPINE1, VEGFA, VCAN
6	chronic ulcer of skin	14.2	CD36, MMP1, MMP13, MMP8, FGF2, TIMP2
7	dupuytren contracture	14.2	SERPINH1, BMP6, CD36, ELN, DCN
8	nephrogenic systemic fibrosis	14.1	F13A1, CTGF, SMAD2, SMAD3, TIMP1, TGFB1
9	marfan syndrome	14.1	BMP6, CD36, MMP2, FBN1, LOX, ELN
10	fibromatosis, gingival	14.1	SERPINH1, CD36, MMP1, MMP2, TGFB1
11	factor v leiden thrombophilia	14.0	SERPINE1, MMP13, MMP8, IFNB1, F13A1, TNC
12	ehlers-danlos syndrome	14.0	CD36, FBN1, LOX, TNC, COL1A1, ELN
13	connective tissue disease	14.0	BMP6, CD36, FBLN5, FBN1, LOX, CTGF
14	crescentic glomerulonephritis	14.0	VCAN, BMP6, CD36, CCL2, CTGF, TGFB1
15	fibrodysplasia ossificans progressiva	14.0	JUN, FOS, FGF2, MAPK14, MAPK1, SMAD7
16	eisenmenger syndrome	13.9	TGFB1, TGFBR1, TGFBR2, TGFBR3
17	thoracic aortic aneurysm	13.9	MMP1, MMP2, FBN1, ELN, TGFBR2
18	cutis laxa	13.9	BMP6, JUN, FOS, FBLN5, FBN1, LOX
19	familial thoracic aortic aneurysm and dissection	13.9	FBN1, SMAD3, TGFBR1, TGFBR2
20	craniosynostosis	13.9	BMP6, FGF1, FGF2, FGFR1, IL11RA, FBN1
21	skin benign neoplasm	13.8	JUN, MMP13, FAP, MAPK1, TP63, COL1A1
22	telangiectasis	13.8	BMP6, FBN1, ELN, TGFBR1
23	odontogenic myxoma	13.8	VCAN, CD36, MMP1, MMP2, MMP9, COL14A1
24	diastolic heart failure	13.7	BMP6, MMP1, MMP2, MMP9, MAPK8
25	proliferative vitreoretinopathy	13.7	BMP6, FOS, FGF1, FGF2, CCL2, TNC
26	venous insufficiency	13.7	SERPINE1, MMP1, FGF2, PLAU, PDGFRA, PDGFRB
27	refractive error	13.7	MMP1, MMP13, MMP2, MMP8, MMP9, TIMP1
28	ocular cicatricial pemphigoid	13.7	SERPINH1, MIF, HLA-DQB1, HLA-DRB1, CTGF, TGFB1
29	tongue cancer	13.7	MMP2, MMP8, MMP9, TNC
30	primary pulmonary hypertension	13.7	SERPINE1, BMP6, FBN1, CCL2, TIMP1, TGFB1
31	hereditary hemorrhagic telangiectasia	13.7	VEGFA, BMP6, SP1, PDGFRA, TGFB1, TGFB2
32	achilles bursitis	13.7	HLA-B, TNC, COMP
33	recessive dystrophic epidermolysis bullosa	13.6	JUN, MMP1, FGF2, FBN1, TP53
34	sorsby fundus dystrophy	13.6	MMP9, ELN, TIMP1, TIMP3
35	hypodontia	13.6	MMP9, TP63, TIMP2, TGFB1, TGFB3
36	hepatitis	13.6	FAS, IFNA2, IFNB1, HLA-A, HLA-DRB1, SMAD3
37	collagenous colitis	13.6	MMP1, MMP9, CTGF, COL14A1, TIMP1
38	cellulitis	13.6	MTOR, JUN, CD36, FAS, SP1, HIF1A
39	acute promyelocytic leukemia	13.6	PIK3CG, JUN, MAPK8, MAPK1, CASP3, CASP9
40	peyronies disease	13.6	BMP6, CD36, CCL2, IFNA2, HLA-A, HLA-B
41	nephrosclerosis	13.6	SERPINE1, CCL2, CTGF, HIF1A, TGFB1
42	21-hydroxylase deficiency	13.6	ITGB1, IFNA2, IFNB1, TIMP1, TIMP3
43	osteogenesis imperfecta	13.6	SERPINH1, CD36, IGF1, LOX, TNC, COL1A1
44	aneurysm disease	13.6	MMP1, MMP9, FBN1, ELN, TIMP1
45	corneal neovascularization	13.6	VEGFA, KDR, CD36, MMP2, FGF2, TIMP2
46	congenital diaphragmatic hernia	13.6	PAX6, KDR, MMP1, FGF2, NR3C1, PDGFRA
47	cblc	13.6	PIK3CB, PIK3CG, KDR, JAK1, IL11RA, IL6R
48	japanese encephalitis	13.6	RAF1, JUN, MAPK14, CASP3, CASP9, DPT
49	epidermolysis bullosa	13.6	SERPINH1, JUN, CD36, MMP1, MMP13, FGF2
50	sm-ahnmd	13.5	FGFR1, IFNA2, PDGFRA, PDGFRB

Approved drugs:

Drug clinical trials:

Genetic tests related to keloids:

id	Genetic test	Affiliating Genes
1	Keloids clinical/research

MalaCards organs/tissues related to keloids:

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MGI Mouse Phenotypes related to keloids:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	PAX6, MT2A, MT1A, FBLN5, FBN1, F13A1
2	craniofacial phenotype	MP:0005382	10.2	PAX6, IL17A, FBLN5, FBN1, MAPK8, IGF1R
3	endocrine/exocrine gland phenotype	MP:0005379	10.2	SFRP2, FOXL2, FGFR1, IFNG, TP63, DDR1
4	embryogenesis phenotype	MP:0005380	9.7	PIK3CB, SFRP2, RAF1, PAX6, FOS, FGFR1
5	limbs/digits/tail phenotype	MP:0005371	9.0	SFRP2, VEGFA, VCAN, CD44, ITGB1, MMP13
6	renal/urinary system phenotype	MP:0005367	9.0	PAX6, MT2A, MT1A, MTOR, ITGB1, FGFR1
7	pigmentation phenotype	MP:0001186	9.0	PAX6, ITGB1, FBN1, FAS, CCL2, CASP3
8	liver/biliary system phenotype	MP:0005370	9.0	VEGFA, MT2A, MT1A, CD36, IL6, IFNG
9	hematopoietic system phenotype	MP:0005397	8.8	PCNA, MT2A, MT1A, JAK1, MIF, FGF2
10	other phenotype	MP:0005395	8.8	SERPINH1, KDR, ITGB1, IL11RA, IL13, FBN1
11	hearing/vestibular/ear phenotype	MP:0005377	8.7	PAX6, ITGB1, FOS, FGF2, FGFR1, IL13
12	digestive/alimentary phenotype	MP:0005381	8.3	VEGFA, PAX6, MT2A, MT1A, CD36, CD44
13	no phenotypic analysis	MP:0003012	7.5	SFRP2, PCNA, VEGFA, CD44, FGFR1, IL13
14	integument phenotype	MP:0010771	7.5	PIK3CG, RAF1, PAX6, CD44, ITGB1, MMP13
15	nervous system phenotype	MP:0003631	6.9	SFRP2, SERPINH1, VCAN, RAF1, PAX6, MT2A
16	adipose tissue phenotype	MP:0005375	6.7	SERPINE1, MTOR, CD36, MMP19, IL6, IL6R
17	behavior/neurological phenotype	MP:0005386	6.4	PAX6, KDR, MT2A, MT1A, MTOR, JUN
18	immune system phenotype	MP:0005387	6.4	RAF1, PAX6, KDR, MT2A, MT1A, MTOR
19	mortality/aging	MP:0010768	6.3	PIK3CB, SFRP2, SERPINH1, SERPINE1, VEGFA, PAX6
20	growth/size phenotype	MP:0005378	6.3	PIK3CB, PIK3CG, SFRP2, SERPINE1, BMP6, RAF1
21	normal phenotype	MP:0002873	6.2	SFRP2, VEGFA, VCAN, PAX6, KDR, MT2A
22	reproductive system phenotype	MP:0005389	5.7	SFRP2, VEGFA, PAX6, MT2A, MT1A, CD44
23	skeleton phenotype	MP:0005390	5.1	PIK3CG, VEGFA, VCAN, BMP6, RAF1, KDR
24	vision/eye phenotype	MP:0005391	5.0	VEGFA, RAF1, PAX6, KDR, MT2A, MT1A
25	tumorigenesis	MP:0002006	4.4	PIK3CB, SERPINE1, PAX6, MT2A, MT1A, CD44
26	muscle phenotype	MP:0005369	4.2	PIK3CG, SFRP2, VEGFA, RAF1, PAX6, KDR
27	homeostasis/metabolism phenotype	MP:0005376	3.8	PIK3CB, PIK3CG, SFRP2, SERPINE1, VEGFA, RAF1
28	cardiovascular system phenotype	MP:0005385	3.3	PIK3CB, PIK3CG, SFRP2, SERPINE1, VEGFA, RAF1
29	cellular phenotype	MP:0005384	2.3	PIK3CB, PIK3CG, SFRP2, PCNA, VEGFA, RAF1

Articles related to keloids:

(show top 50)    (show all 214)

id	Title	Authors	Year	Affiliating Genes
1	Increased expression of fibroblast activation protein -alpha in keloid fibroblasts: implications for development of a novel treatment option. (20872224)	Dienus K.... Seifert O.	2010	FAP
2	Matrix metalloproteinases and tissue inhibitors of me talloproteinases in patients with different types of scars and keloids. (19464975)	Ulrich D.... Pallua N.	2010	MMP2, MMP9, MMP1
3	Identification of novel keloid biomarkers through pro filing of tissue biopsies versus cell cultures in keloid margin specimens compa red to adjacent normal skin. (20418938)	Shih B.... Bayat A.	2010	TNFAIP6, ASPN
4	Enhanced MCP-1 release by keloid CD14+ cells augments fibroblast proliferation: role of MCP-1 and Akt pathway in keloids. (20100200)	Liao W.T.... Lee C.H.	2010	AKT1, CCL2
5	TGF-A91 antisense impacts the SMAD signalling system i n fibroblasts from keloid scars. (20944123)	Bran G.M.... Sadick H.	2010	TGFB1
6	Troglitazone suppresses transforming growth factor-beta1-induced collagen type I expression in keloid fibroblasts. (19120328)	Zhang G.Y.... Gao W.Y.	2009	CD36
7	Promoted activation of matrix metalloproteinase (MMP)-2 in keloid fibroblasts and increased expression of MMP-2 in collagen bundle regions: implications for mechanisms of keloid progression. (19438747)	Imaizumi R.... Maruyama Y.	2009	MMP2, TIMP2, TIMP3
8	Expression and function of sphingosine kinases 1 and 2 in human keloid fibroblasts (19567073)	Zhang J.... Cai J.L.	2009	TGFB1, SPHK1, SPHK2
9	Effect of camptothecin on collagen synthesis in fibro blasts from patients with keloid. (19546682)	Zhang G.Y.... Guo S.Z.	2009	CD36
10	Gene expression profiling reveals alteration of caspase 6 and 14 transcripts in normal skin of keloid-prone patients. (18762957)	Nassiri M.... Vincek V.	2009	CASP6, CASP14
11	Tumor-like stem cells derived from human keloid are g overned by the inflammatory niche driven by IL-17/IL-6 axis. (19907660)	Zhang Q.... Le A.D.	2009	IL6, IL17A
12	Correlation analysis between clinical phenotypes of keloids and polymorphism of p53 gene codon 72 (19137883)	Liu Y.... Liu H.	2008	TP53
13	Relationship between mutation at 1 573 fragment of TNF receptor II gene and keloid (19068596)	Zhang G.... Liang L.	2008	TNFRSF1B
14	TGF-beta1 antisense therapy modulates expression of matrix metalloproteinases in keloid-derived fibroblasts. (18575776)	Sadick H.... Riedel F.	2008	MMP2, TGFB1, MMP9
15	TWEAK inhibits TGF-beta-induced contraction of normal and keloid fibroblast-embedded collagen gel. (17178215)	Tsuchihashi H.... Okumura K.	2007	TNFSF12
16	Inhibition of Smad3 expression decreases collagen synthesis in keloid disease fibroblasts. (17889631)	Wang Z.... Jin Y.	2007	SMAD3, BMP6
17	Differential p63 and p53 expression in human keloid fibroblasts and hypertrophic scar fibroblasts. (17688405)	De Felice B.... Garbi C.	2007	TP63
18	Association between p53 gene codon 72 polymorphism and keloid in Chinese population (18161363)	Yan L.... Zhuang Q.	2007	TP53
19	Gene expression patterns in isolated keloid fibroblasts. (16939575)	Satish L.... Wells A.	2006	TAGLN
20	Dexamethasone induction of keloid regression through effective suppression of VEGF expression and keloid fibroblast proliferation. (16575391)	Wu W.S.... Kuo Y.R.	2006	KDR, VEGFA, NR3C1
21	Keloids and scars: a review of keloids and scars, the ir pathogenesis, risk factors, and management. (16914994)	Slemp A.E.... Kirschner R.E.	2006	BMP6
22	Increased transcriptional response to mechanical strain in keloid fibroblasts due to increased focal adhesion complex formation. (16155910)	Wang Z.... Yang G.P.	2006	TGFB1, TGFB2
23	Decreased expression of inhibitory SMAD6 and SMAD7 in keloid scarring. (16676428)	Yu H.... Mrowietz U.	2006	SMAD2, SMAD3, BMP6
24	Activated caspase expression and apoptosis increase in keloids: cytochrome c release and caspase-9 activation during the apoptosis of keloid fibroblast lines. (16008726)	Akasaka Y.... Ishii T.	2005	CASP9
25	Expression of thymosin beta4 mRNA expression in keloid tissues and fibroblasts cultured from keloid and its significance. (15698487)	Nie F.F.... Qin Z.L.	2005	TMSB4X
26	Molecular characterization and expression of p63 isoforms in human keloids. (15248062)	De Felice B.... Pinelli C.	2004	TP63
27	Experimental study on apoptosis of keloid-derived fibroblast transducted with Fas gene by recombinant adenovirus (15568750)	Lu F.... Gao J.H.	2004	FAS
28	Increased vascular endothelial growth factor may account for elevated level of plasminogen activator inhibitor-1 via activating ERK1/2 in keloid fibroblasts. (14644771)	Wu Y.... Le A.D.	2004	PLAU, SERPINE1, VEGFA
29	Genetic susceptibility to keloid disease: transforming growth factor beta receptor gene polymorphisms are not associated with keloid disease. (15009106)	Bayat A.... Ferguson M.W.	2004	TGFBR2, TGFBR1, TGFB1
30	Elevated vascular endothelial growth factor in keloids: relevance to tissue fibrosis. (14745238)	Le A.D.... Bertolami C.N.	2004	VEGFA
31	Complex epithelial-mesenchymal interactions modulate transforming growth factor-beta expression in keloid-derived cells. (15453837)	Xia W.... Yang G.P.	2004	TGFB1, SMAD2, CD36
32	A study of the abnormalities of human epiderm in keloids and hypertrophic scars (15363271)	He X.J.... Peng J.P.	2004	TNC
33	Insulin-like growth factor-I enhances transforming growth factor-beta-induced extracellular matrix protein production through the P38/activating transcription factor-2 signaling pathway in keloid fibroblasts. (12787120)	Daian T.... Yamashita S.	2003	IGF1R, MAPK14, CD36
34	Effect of blended CO2 and erbium:YAG laser irradiation on normal and keloid fibroblasts: a serum-free study. (14709217)	Cheng E.T.... Koch R.J.	2003	FGF2
35	Expression of urokinase-type plasminogen activator an d its receptor in keloids. (14676162)	Leake D.... Scott G.	2003	PLAUR
36	Increased plasminogen activator inhibitor-1 in keloid fibroblasts may account for their elevated collagen accumulation in fibrin gel cultures. (12707042)	Tuan T.L.... Le A.	2003	SERPINE1
37	Suppression of insulin-like growth factor signalling pathway and collagen expression in keloid-derived fibroblasts by quercetin: its therapeutic potential use in the treatment and/or prevention of keloids. (12653748)	Phan T.T.... Huynh H.	2003	RAF1, IGF1R
38	An experimental study of antisense TGF-beta 1 inhibi ting keloid fibroblast proliferation in vitro (11838050)	Shang Q.... Wang W.	2001	TGFB1
39	Upregulation of HSP47 and collagen type III in the dermal fibrotic disease, keloid. (11162672)	Naitoh M.... Nagata K.	2001	CD36, SERPINH1
40	Differential effects of hexoses and sucrose, and platelet-derived growth factor isoforms on cyclooxygenase-1 and -2 mRNA expression in keloid, hypertrophic scar and granulation tissue fibroblasts. (11357226)	KAPssi J.... Laato M.	2001	PTGS1, COX5A
41	Enhanced expression of caspase-3 in hypertrophic scars and keloid: induction of caspase-3 and apoptosis in keloid fibroblasts in vitro. (10744070)	Akasaka Y.... Ishii T.	2000	CASP3
42	The distrubution of cell cycle on fibrolasts derived from the pathlogical scars and analysis of Fas gene mutations in keloids using polymerse chain Reaction-based single-strand conformation polymorphism (11798842)	Lu F.... Li X.	2000	FAS
43	The effect of superpulsed carbon dioxide laser energy on keloid and normal dermal fibroblast secretion of growth factors: a serum-free study. (10839401)	Nowak K.C.... Koch R.J.	2000	TGFB1, FGF2
44	Keloids in rural black South Africans. Part 3: a lipid model for the prevention and treatment of keloid formations. (11090251)	Louw L.	2000	DYT10
45	Downregulation of apoptosis-related genes in keloid tissues. (10600351)	Sayah D.N.... Ting K.	1999	NME2, TRADD, DYNLL1
46	Gelatinase activity in keloids and hypertrophic scars. (10417752)	Neely A.N.... Warden G.D.	1999	MMP2
47	p53 and apoptosis alterations in keloids and keloid fibroblasts. (9776848)	Ladin D.A.... Fivenson D.P.	1998	TP53, FAS, IFNG
48	Major suppression of pro-alpha1(I) type I collagen ge ne expression in the dermis after keloid excision and immediate intrawound inje ction of triamcinolone acetonide. (9344198)	Kauh Y.C.... Tan E.M.	1997	CD36
49	Exposure of fibroblasts derived from keloid patients to low-energy electromagnetic fields: preferential inhibition of cell proliferation, collagen synthesis, and transforming growth factor beta expression in keloid fibroblasts in vitro. (9374152)	Nakajima H.... Tajima S.	1997	CD36, BMP6
50	The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblasts. (1282576)	Suzawa H.... Koda A.	1992	TGFB1

Genes related to keloids according to GeneCards:

(show top 50)    (show all 148)

id	Symbol	Description	Score	GeneCards Section Context
1	TKCR	torticollis, keloids, cryptorchidism and renal dysplasia	11.0	Publications, Aliases & Descriptions
2	SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	11.0	Publications
3	CTGF	connective tissue growth factor	11.0	Publications
4	TGFB3	transforming growth factor, beta 3	11.0	Publications
5	SMAD7	SMAD family member 7	11.0	Publications
6	DCN	decorin	11.0	Publications
7	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
8	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
9	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0	Publications
10	KRT14	keratin 14	11.0	Publications
11	DDR1	discoidin domain receptor tyrosine kinase 1	11.0	Publications
12	TGFB2	transforming growth factor, beta 2	11.0	Publications
13	TGFB1	transforming growth factor, beta 1	11.0	Publications
14	TGFBR1	transforming growth factor, beta receptor 1	11.0	Publications
15	LOX	lysyl oxidase	11.0	Publications
16	BMP6	bone morphogenetic protein 6	11.0	Publications
17	TNC	tenascin C	11.0	Publications
18	SMAD2	SMAD family member 2	11.0	Publications
19	SMAD3	SMAD family member 3	11.0	Publications
20	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
21	ELN	elastin	11.0	Publications
22	FGF2	fibroblast growth factor 2 (basic)	11.0	Publications
23	FAS	Fas (TNF receptor superfamily, member 6)	11.0	Publications
24	TIMP2	TIMP metallopeptidase inhibitor 2	11.0	Publications
25	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
26	IFNA2	interferon, alpha 2	11.0	Publications
27	JUN	jun proto-oncogene	11.0	Publications
28	SP1	Sp1 transcription factor	11.0	Publications
29	MAPK8	mitogen-activated protein kinase 8	11.0	Publications
30	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	11.0	Publications
31	IGF1R	insulin-like growth factor 1 receptor	11.0	Publications
32	MAPK14	mitogen-activated protein kinase 14	11.0	Publications
33	F13A1	coagulation factor XIII, A1 polypeptide	11.0
34	MAPK1	mitogen-activated protein kinase 1	11.0	Publications
35	MT1G	metallothionein 1G	10.9	Publications
36	MT1X	metallothionein 1X	10.9	Publications
37	MT1F	metallothionein 1F	10.9	Publications
38	ASPN	asporin	10.9	Publications
39	RRP1	ribosomal RNA processing 1 homolog (S. cerevisiae)	10.9	Publications
40	P4HTM	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)	10.9	Publications
41	HSPB6	heat shock protein, alpha-crystallin-related, B6	10.9	Publications
42	MT1A	metallothionein 1A	10.9	Publications
43	SKOR1	SKI family transcriptional corepressor 1	10.9	Publications
44	CBR3	carbonyl reductase 3	10.9	Publications
45	FAM215A	family with sequence similarity 215, member A (non-protein coding)	10.9	Publications
46	KRT2	keratin 2	10.9	Expressions
47	TGFB1I1	transforming growth factor beta 1 induced transcript 1	10.9	Publications
48	TMSB4X	thymosin beta 4, X-linked	10.9	Publications
49	TNFAIP6	tumor necrosis factor, alpha-induced protein 6	10.9	Publications
50	MMP19	matrix metallopeptidase 19	10.9	Publications

Pathways related to keloids according to GeneDecks:

(show top 50)    (show all 360)

id	Pathway	Score	Top Affiliating Genes
1	Breast Cancer Regulation by Stathmin136	10.7	RAF1, FGF1, FGF2, IGF1R, PDGFA, TIMP3
2	Colorectal cancer20	10.7	PIK3CB, PIK3CG, FOS, MAPK8, CASP9, SMAD2
3	Signal transduction_PTEN pathway41	10.6	PCNA, ITGB1, IGF1R, CASP9
4	Actin-Based Motility by Rho Family GTPases36	10.4	IGF1, CTGF, TGFB3, TGFBR1, HDGF
5	Cell adhesion Plasmin signaling10	10.2	VEGFA, KDR, MMP13, FGF2, FGFR1, MAPK14
6	Cell adhesion_Plasmin signaling41	10.2	PIK3CB, VEGFA, KDR, MMP13, FGF2, FGFR1
7	TGF-beta Signaling Pathways37	10.1	PIK3CB, PIK3CG, RAF1, MTOR, JUN, FOS
8	Glioma Invasiveness36	10.0	BMP6, CD44, ITGB1, FGF1, FGF2, PLAU
9	Ras Pathway36	10.0	RAF1, KDR, JUN, ITGB1, FOS, FGF1
10	PTEN Pathway36	9.8	KDR, FGF1, FGF2, FGFR1, FBN1, MAPK1
11	Th17 Differentiation37	9.7	JAK1, IL17A, IL6, IL6R, SMAD2, SMAD3
12	MAPK signaling pathway20	9.5	RAF1, JUN, FOS, FGF1, FGF2, FGFR1
13	mTOR Pathway36	9.4	BMP6, FGF1, FGF2, IL6, MAPK8, MAPK14
14	Focal adhesion20	9.4	PIK3CB, PIK3CG, RAF1, KDR, JUN, ITGB1
15	ERK5 Signaling36	9.3	BMP6, KDR, FOS, FGF1, FGFR1, IL6
16	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.3	IL17A, IL6, IL6R, IFNG, TLR6, TLR7
17	UPA-UPAR Pathway36	9.3	SERPINE1, JUN, JAK1, ITGB1, MMP1, MMP13
18	Rac1 Pathway36	9.3	BMP6, RAF1, KDR, JUN, ITGB1, FGF1
19	Inhibition of Angiogenesis by TSP136	9.3	KDR, JUN, CD36, MMP9, FOS, FBN1
20	Activation of PKC through GPCR36	9.3	BMP6, RAF1, KDR, FGF1, FGF2, FGFR1
21	Nuclear Receptor Activation by Vitamin-A36	9.2	BMP6, KDR, FGF1, FGF2, FGFR1, IL6
22	Endothelin-1 Signaling Pathway36	9.2	BMP6, RAF1, IL10, IL13, IL24, IL6
23	Signal transduction PTEN pathway10	9.2	PIK3CB, PCNA, RAF1, MTOR, JUN, ITGB1
24	Telomerase Components in Cell Signaling36	9.1	BMP6, KDR, FGF1, FGF2, FGFR1, IGF1R
25	NF-KappaB (p50-p65) Pathway36	9.1	BMP6, KDR, FGF1, FGF2, FGFR1, IL6
26	PPAR Pathway36	9.1	RAF1, ITGB1, FGF1, FGF2, FGFR1, IL6
27	Rap1 Pathway36	9.0	BMP6, RAF1, ITGB1, FGF1, FGF2, FGFR1
28	Activation of PKA through GPCR36	9.0	BMP6, RAF1, KDR, FGF1, FGF2, FGFR1
29	Cell adhesion ECM remodeling10	9.0	SERPINE1, VCAN, CD44, ITGB1, MMP1, MMP13
30	Apoptotic Pathways in Synovial Fibroblasts36	8.9	BMP6, KDR, FGF1, FGF2, FGFR1, IL6
31	Cell adhesion_ECM remodeling41	8.9	SERPINE1, VCAN, CD44, ITGB1, MMP1, MMP13
32	Influenza A20	8.8	PIK3CB, PIK3CG, RAF1, JUN, JAK1, IL6
33	Phospholipase-C Pathway36	8.7	BMP6, RAF1, KDR, ITGB1, FGF1, FGF2
34	Mitochondrial Apoptosis36	8.7	BMP6, KDR, FGF1, FGF2, FGFR1, IL6
35	Development_VEGF signaling via VEGFR2 - generic cascades41	8.7	PIK3CB, VEGFA, RAF1, JUN, FOS, MAPK1
36	Angiogenesis3	8.7	KDR, ITGB1, MMP2, MMP9, FGF1, FGF2
37	Transcription_Androgen Receptor nuclear signaling41	8.7	RAF1, MMP2, IL6, IL6R, MAPK1, CCND1
38	GPCR Pathway36	8.6	BMP6, RAF1, KDR, JUN, FOS, FGF1
39	Toxoplasmosis20	8.6	PIK3CB, PIK3CG, JAK1, ITGB1, IL10, MAPK8
40	Cellular Apoptosis Pathway36	8.6	BMP6, KDR, FGF1, FGF2, FGFR1, IL6
41	MAPK Signaling36	8.4	BMP6, RAF1, KDR, JUN, ITGB1, FOS
42	Akt Signaling36	8.3	PIK3CG, RAF1, FGF1, FGFR1, IL10, IL11RA
43	Estrogen Pathway36	8.3	BMP6, RAF1, KDR, JUN, FOS, FGF1
44	MAPK Family Pathway36	8.3	BMP6, RAF1, KDR, JUN, FGF1, FGF2
45	Tuberculosis20	8.1	RAF1, JAK1, IL10, IL6, MAPK8, MAPK14
46	Antioxidant Action of Vitamin-C36	7.9	BMP6, KDR, JUN, FOS, FGF1, FGF2
47	Pathways in cancer20	7.9	PIK3CB, PIK3CG, VEGFA, MTOR, JUN, JAK1
48	Rho Family GTPases36	7.8	BMP6, RAF1, KDR, JUN, ITGB1, FOS
49	Colorectal Cancer Metastasis36	7.5	JAK1, MMP1, MMP2, MMP9, IL6, IL6R
50	JAK-STAT Pathway36	7.1	BMP6, RAF1, KDR, JUN, JAK1, FOS

Compounds related to keloids according to GeneDecks:

(show top 50)    (show all 402)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.6	VCAN, PAX6, MT2A, MIF, FGFR1, LOX
2	ns 39832 42	11.5	PIK3CG, PCNA, MMP1, FGF2, IL17A, MAPK8
3	manumycin32	10.2	RAF1, MAPK8, MAPK14, DYT10, NFKBIA
4	hydroxyproline32 18	10.8	BMP6, P4HTM, CD36, ITGB1, MMP1, MMP13
5	alginate32	9.8	VCAN, CD36, CD44, MMP13, MMP2, FGF2
6	hyaluronic acid32 18	10.7	VCAN, BMP6, CD36, CD44, MMP1, MMP13
7	heparin32 9 18 9	12.7	PIK3CG, SERPINE1, VCAN, RAF1, CD36, ITGB1
8	rottlerin32 42	10.5	PIK3CG, JUN, CD36, IL6R, MAPK8, MAPK14
9	etoposide32 42 9 9	12.4	PIK3CB, PIK3CG, PCNA, JUN, CD44, MMP2
10	losartan32 34 9 9	12.3	PCNA, SERPINE1, BMP6, CD36, MMP1, FOS
11	fibrinogen32	9.3	PIK3CB, SERPINE1, ITGB1, MMP13, MMP8, FGFR1
12	calcitriol32 42 9 18 9	13.3	PIK3CB, BMP6, JUN, CD36, CD44, ITGB1
13	rapamycin32 42	10.3	PIK3CG, VEGFA, RAF1, KDR, MTOR, MAPK8
14	gnrh32	9.1	SERPINE1, RAF1, FGFR1, CCL2, IGF1, AKT1
15	calcium32 9 18 9	12.0	MT2A, MT1G, CD36, CD44, ITGB1, MMP1
16	anisomycin32 42 9 9	11.7	PIK3CG, RAF1, MTOR, JUN, FOS, IL6
17	cytochalasin d32 42	9.5	PIK3CG, RAF1, CD36, CD44, MMP1, MMP2
18	prednisolone32 9 9	10.5	BMP6, CD44, MMP1, MMP13, MMP2, FGF2
19	estrogen32	8.5	PIK3CB, PCNA, SERPINE1, RAF1, KDR, MT2A
20	retinoid32	8.3	BMP6, JUN, MMP1, MMP13, FOS, IL17A
21	prostacyclin32	8.3	SERPINE1, VEGFA, BMP6, KDR, FGF1, FGF2
22	5fluorouracil32	8.3	PIK3CG, PCNA, VEGFA, KDR, MTOR, CD36
23	aspirin32 34 18	10.3	PCNA, SERPINE1, BMP6, RAF1, MMP1, MMP2
24	lactacystin32	8.2	PIK3CG, RAF1, JUN, MMP9, MAPK8, MAPK14
25	gefitinib32 34 9 9	11.2	PIK3CG, VEGFA, KDR, MTOR, MMP2, MMP9
26	troglitazone32 42 9 9	11.0	PIK3CG, SERPINE1, BMP6, JUN, CD36, MMP1
27	paclitaxel32 34 9 9	11.0	PIK3CG, PCNA, VEGFA, BMP6, RAF1, KDR
28	celecoxib32 42 34 9 18 9	13.0	PIK3CG, PCNA, VEGFA, KDR, MMP1, MMP2
29	glutamate32	8.0	PIK3CB, PCNA, BMP6, KDR, MMP2, MMP9
30	lipid32	7.9	PIK3CB, PIK3CG, SERPINE1, MT2A, MTOR, JAK1
31	cyclosporin a32 42	8.9	PIK3CG, SERPINH1, RAF1, MTOR, JUN, CD44
32	rantes32	7.7	BMP6, JUN, CD44, MMP1, MMP13, MMP9
33	arginine32	7.5	PAX6, CD44, FGF1, IL13, IL6R, FBN1
34	hydrocortisone32 9 9	9.5	BMP6, KDR, CD36, MMP1, MMP2, MIF
35	doxorubicin32 34 9 9	10.5	PIK3CG, VEGFA, BMP6, RAF1, KDR, MTOR
36	tacrolimus32 34 9 9	10.5	PCNA, SERPINE1, BMP6, RAF1, MTOR, CD36
37	alanine32	7.4	PCNA, BMP6, RAF1, PAX6, JAK1, MMP2
38	ag 147832	7.3	PIK3CG, SERPINE1, RAF1, JUN, MMP2, MMP9
39	adenylate32	7.3	PIK3CG, SERPINE1, CD44, MMP9, FOS, FGF1
40	cysteine32	7.3	PCNA, RAF1, KDR, MT2A, CD44, ITGB1
41	indomethacin32 9 9	9.2	PCNA, BMP6, RAF1, KDR, MMP1, MMP13
42	butyrate32	7.2	PCNA, BMP6, RAF1, JUN, JAK1, CD44
43	nitric oxide32 9 18 9	10.1	PIK3CB, SERPINH1, BMP6, KDR, JAK1, CD44
44	sb 20358032 42	7.7	VEGFA, BMP6, CD36, ITGB1, MMP1, MMP13
45	curcumin32	6.4	PIK3CG, VEGFA, RAF1, JUN, JAK1, MMP1
46	15-deoxy-delta-12,14-prostaglandin j232	6.3	PIK3CG, SERPINE1, VEGFA, BMP6, JUN, JAK1
47	cisplatin32 34 9 9	9.3	PCNA, VEGFA, BMP6, RAF1, KDR, MT2A
48	actinomycin d32	5.2	PIK3CG, SERPINE1, VEGFA, JUN, CD44, MMP13
49	retinoic acid32 42 18	6.6	PIK3CG, SERPINE1, BMP6, RAF1, PAX6, KDR
50	dexamethasone32 42 34 9 9	8.5	PCNA, SERPINE1, VEGFA, BMP6, RAF1, KDR

Cellular components related to keloids according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix	GO:031012	10.5	TGFB3, TGFB2, TGFB1I1, TIMP3, COL14A1, COMP
2	proteinaceous extracellular matrix	GO:005578	10.1	DPT, POSTN, TGFBR3, TGFB1, MMP1, MMP13
3	platelet alpha granule lumen	GO:031093	10.0	PDGFA, F13A1, TGFB2, TGFB3, TGFB1, TIMP1
4	cell surface	GO:009986	9.7	RSPO2, TGFB1, TGFB2, TGFBR3, TGFB3, CXCR2
5	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.4	HLA-B, HLA-C, HLA-DQA1, HLA-DQB1, HLA-A, HLA-DRB1
6	ER to Golgi transport vesicle membrane	GO:012507	9.2	HLA-DRB1, HLA-DQA1, HLA-C, HLA-B, HLA-A, HLA-DQB1
7	external side of plasma membrane	GO:009897	9.1	TGFBR3, TGFBR2, HLA-DRB1, FAS, IFNG, IL17A
8	membrane	GO:016020	8.3	PIK3CG, NR3C1, PDGFRB, CXCR2, GAPDH, SPHK2
9	nucleoplasm	GO:005654	8.1	JUN, CASP3, CCND1, MAPK1, CASP6, HIF1A
10	cytosol	GO:005829	8.0	TRADD, FGFR1, PIK3CB, PIK3CG, AKT1, CASP9
11	extracellular space	GO:005615	6.9	IL24, IL6, IL6R, FBLN5, FBN1, FAP
12	extracellular region	GO:005576	6.9	VEGFA, FAS, CCL2, IGF1, IFNA2, IFNB1
13	cytoplasm	GO:005737	6.6	CBR3, HSPB6, CASP3, CASP6, CASP14, AKT1
14	nucleus	GO:005634	6.3	DYNLL1, SPHK1, NR3C1, SMAD2, SMAD3, SMAD6

Biological processes related to keloids according to GeneDecks:

(show top 50)    (show all 103)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of epithelial to mesenchymal transition	GO:010718	10.9	TGFB2, TGFB3, TGFB1I1, TGFB1, COL1A1, SMAD3
2	collagen fibril organization	GO:030199	10.8	COL1A1, COL14A1, TGFB2, TGFBR1, DPT, LOX
3	pathway-restricted SMAD protein phosphorylation	GO:060389	10.8	TGFBR2, TGFBR1, TGFB2, TGFB1, TGFBR3, SMAD7
4	response to laminar fluid shear stress	GO:034616	10.8	TGFB1, SMAD7, TGFB3, TGFB2, SMAD6
5	wound healing	GO:042060	10.7	SMAD3, DCN, TGFB2, RAF1, FGF2, LOX
6	negative regulation of transforming growth factor beta receptor signaling pathway	GO:030512	10.7	SMAD7, NR3C1, ASPN, SMAD2, SMAD3, SMAD6
7	cellular response to zinc ion	GO:071294	10.7	MT1A, MT1G, MT1X, MT2A, MT1F
8	collagen catabolic process	GO:030574	10.6	MMP9, MMP1, PEPD, MMP8, MMP2, MMP13
9	induction of apoptosis	GO:006917	10.6	CASP3, TRADD, FAS, CASP6, IFNA2, MAPK1
10	aging	GO:007568	10.6	CCL2, PTGS1, JUN, TIMP1, TIMP3, FAS
11	extracellular matrix disassembly	GO:022617	10.6	TIMP1, MMP1, MMP13, MMP2, MMP8, MMP9
12	negative regulation of growth	GO:045926	10.5	MT1A, MT1G, MT1F, MT1X, MT2A, HIF1A
13	positive regulation of cell division	GO:051781	10.5	TGFB3, PDGFA, FGF2, FGF1, VEGFA, TGFB1
14	extracellular matrix organization	GO:030198	10.5	COL1A1, MMP9, MMP8, TIMP2, TIMP1, ELN
15	transforming growth factor beta receptor signaling pathway	GO:007179	10.4	TGFBR1, TGFB3, TGFB2, TGFB1, SMAD7, SMAD6
16	response to wounding	GO:009611	10.4	PDGFA, CTGF, TGFB1, TGFB2, PAX6, CASP3
17	platelet degranulation	GO:002576	10.2	IGF1, VEGFA, F13A1, TMSB4X, PDGFA, TIMP1
18	positive regulation of cell migration	GO:030335	10.1	PDGFRA, PDGFRB, COL1A1, TGFB1, SMAD3, SPHK1
19	positive regulation of angiogenesis	GO:045766	10.0	TNFSF12, HIF1A, SPHK1, VEGFA, SERPINE1, KDR
20	angiogenesis	GO:001525	10.0	CCL2, MMP19, MAPK14, FGFR1, MMP2, TNFSF12
21	positive regulation of endothelial cell proliferation	GO:001938	10.0	KDR, HIF1A, TNFSF12, CCL2, FGF2, JUN
22	vascular endothelial growth factor receptor signaling pathway	GO:048010	10.0	MAPK14, VEGFA, KDR, CCL2, PDGFRA, PDGFRB
23	cellular response to mechanical stimulus	GO:071260	9.9	TLR8, COL1A1, MAPK8, FAS, IL13, ITGB1
24	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.9	KDR, CD44, MIF, FGF2, CTGF, PDGFA
25	response to hypoxia	GO:001666	9.9	VEGFA, MMP9, RAF1, SMAD3, HIF1A, TGFB1
26	positive regulation of mesenchymal cell proliferation	GO:002053	9.8	TGFBR2, PDGFA, TP63, IFNG, FGFR1, KDR
27	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.7	NEDD4, TGFB2, PDGFRB, PDGFRA, PDGFA, IGF1
28	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.7	VEGFA, RAF1, CD44, MIF, IL6, AKT1
29	skeletal system development	GO:001501	9.7	MMP9, FBN1, IGF1, TP63, BMP6, FGFR1
30	response to cytokine stimulus	GO:034097	9.6	JUN, IL6R, CASP6, PTGS2, TIMP1, SERPINE1
31	platelet activation	GO:030168	9.4	TGFB3, SERPINE1, PIK3CG, PIK3CB, VEGFA, RAF1
32	virus-host interaction	GO:019048	9.4	KDR, ITGB1, MMP1, MAPK1, HLA-B, HLA-C
33	apoptotic process	GO:006915	9.4	FAM215A, FAS, IL24, MAPK8, MAPK1, IFNG
34	phosphatidylinositol-mediated signaling	GO:048015	9.4	PDGFRA, AKT1, CASP9, IGF1, PIK3CB, IGF1R
35	positive regulation of MAPK cascade	GO:043410	9.3	IGF1, PDGFA, KDR, CD36, ITGB1, FGFR1
36	immune response	GO:006955	9.2	TGFBR3, TNFSF12, TLR6, BMP6, IL13, SMAD3
37	interferon-gamma-mediated signaling pathway	GO:060333	9.1	MT2A, JAK1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B
38	negative regulation of apoptotic process	GO:043066	9.0	PIK3CG, CASP3, VEGFA, RAF1, IGF1R, KDR
39	blood coagulation	GO:007596	9.0	DGKQ, TGFB3, TGFB2, TGFB1, TIMP1, PDGFA
40	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.0	MIF, TP53, IGF1, IL6R, IL6, VEGFA
41	positive regulation of cell proliferation	GO:008284	9.0	TGFB1, TGFB2, FGF2, PDGFRB, IGF1R, TIMP1
42	negative regulation of cell proliferation	GO:008285	8.7	FGF2, DPT, TGFB3, TGFB2, TGFB1I1, RAF1
43	positive regulation of transcription, DNA-dependent	GO:045893	8.5	SMAD3, COL1A1, HIF1A, TGFB1, TGFB1I1, TGFB3
44	anti-apoptosis	GO:006916	8.5	COMP, IGF1, AKT1, SPHK2, SPHK1, NR3C1
45	positive regulation of smooth muscle cell proliferation	GO:048661	8.4	JUN, IGF1, IL13, IL6, IL6R, PTGS2
46	cytokine-mediated signaling pathway	GO:019221	8.1	CCL2, IFNA2, IL6R, IFNB1, IL6, CD44
47	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.1	TP63, TP53, AKT1, IFNG, SP1, SMAD2
48	signal transduction	GO:007165	8.1	IGF1, TLR6, TGFBR1, CXCR2, POMC, STAT3
49	inflammatory response	GO:006954	8.0	IFNA2, IL6, IL17A, MIF, IL10, IL13
50	response to drug	GO:042493	8.0	IFNG, LOX, CCND1, CCL2, STAT3, TGFBR2

Molecular functions related to keloids according to GeneDecks:

(show all 24)

id	Name	GO ID	Score	Top Affiliating Genes
1	type II transforming growth factor beta receptor binding	GO:005114	10.9	TGFB2, TGFB3, TGFBR3, TGFBR1, TGFB1
2	I-SMAD binding	GO:070411	10.8	SMAD2, TGFBR1, SMAD6, TGFB1I1, SMAD7
3	type I transforming growth factor beta receptor binding	GO:034713	10.8	SMAD2, SMAD6, SMAD7, TGFBR2, TGFB3
4	transforming growth factor beta binding	GO:050431	10.8	TGFB3, CD36, TGFBR1, TGFBR2, TGFBR3
5	transforming growth factor beta receptor binding	GO:005160	10.7	SMAD2, SMAD3, TGFBR3, TGFB2
6	glycosaminoglycan binding	GO:005539	10.6	HABP2, VCAN, TGFBR2, TGFBR3, DCN
7	co-SMAD binding	GO:070410	10.5	PAX6, SMAD6, SMAD3, SMAD2
8	R-SMAD binding	GO:070412	10.5	SMAD3, PAX6, SMAD2, SMAD6, JUN, FOS
9	collagen binding	GO:005518	10.4	DCN, PDGFA, COL14A1, COMP, SMAD7, DDR1
10	metalloendopeptidase activity	GO:004222	10.3	MMP8, MMP1, MMP9, FAP, ADAM12, MMP2
11	fibronectin binding	GO:001968	10.3	CTGF, MMP9, ITGB1, VEGFA, SFRP2
12	heparin binding	GO:008201	10.2	COMP, POSTN, TGFBR3, VEGFA, FGF1, FGFR1
13	platelet-derived growth factor binding	GO:048407	10.1	PDGFRA, PDGFRB, PDGFA, COL1A1
14	ubiquitin protein ligase binding	GO:031625	10.0	SMAD2, SMAD6, PAX6, TP53, TNFRSF1B, SMAD3
15	platelet-derived growth factor receptor binding	GO:005161	10.0	PDGFA, VEGFA, PDGFRB, PDGFRA
16	vascular endothelial growth factor binding	GO:038085	10.0	KDR, PDGFRA, PDGFRB
17	transcription regulatory region DNA binding	GO:044212	9.9	JUN, STAT3, HIF1A, SMAD7, SMAD6, SMAD3
18	integrin binding	GO:005178	9.9	SFRP2, KDR, ITGB1, FBLN5, IGF1, CTGF
19	protein heterodimerization activity	GO:046982	9.8	PDGFA, TGFB1, TLR6, VEGFA, RAF1, ITGB1
20	identical protein binding	GO:042802	9.6	TP63, TP53, TGFB3, NFKBIA, COL1A1, TRADD
21	growth factor activity	GO:008083	9.2	BMP6, TGFB3, TGFB2, TGFB1, PDGFA, CTGF
22	cytokine activity	GO:005125	8.9	FGF2, VEGFA, TGFB2, TNFSF12, BMP6, IFNB1
23	protein homodimerization activity	GO:042803	8.8	NR3C1, PDGFA, PDGFRA, TGFB1, SMAD3, TGFB2
24	protein binding	GO:005515	4.2	PCNA, MMP2, MMP9, PLAU, FOXL2, MIF