MCID: KLD001
MIFTS: 52

Keloids malady

Summaries for Keloids

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A keloid (/ˈkiːlɔɪd/; also keloidal scar) is the formation that a type of scar which, depending on... more...

MalaCards: Keloids, also known as keloid, is related to hypertrophic scars and localized scleroderma. An important gene associated with Keloids is TGFB3 (transforming growth factor, beta 3), and among its related pathways are GPCR Pathway and Rho Family GTPases. The compounds vegf and oligonucleotide have been mentioned in the context of this disorder. Affiliated tissues include kidney, breast and skin, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Aliases & Classifications for Keloids

Sources:
20GeneTests, 45Novoseek
See all sources

Aliases & Descriptions:

keloids 20
keloid 45


Related Diseases for Keloids

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Keloids via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1hypertrophic scars31.5TGFB1, TGFB3, SMAD7, SMAD2, SMAD3, SERPINH1
2localized scleroderma30.0CD36, DCN, LOX
3proliferative vitreoretinopathy29.8TGFB2
4fibromatosis29.8TGFB3, TIMP2
5systemic scleroderma29.8CTGF
6keloid formation10.6
7torticollis keloids cryptorchidism renal dysplasia10.4
8syndactyly10.3
9rubinstein-taybi syndrome10.2
10acne10.2
11scar contracture10.2
12burn scar10.2
13burns10.1
14lobomycosis10.1
15herpes zoster10.1
16blastomycosis10.1
17acro-osteolysis-keloid-like lesions-premature aging syndrome10.1
18renal dysplasia10.1
19cryptorchidism10.0
20folliculitis10.0
21bethlem myopathy10.0
22n syndrome10.0
23basal cell carcinoma10.0
24anterior segment mesenchymal dysgenesis10.0
25pulmonary fibrosis10.0TGFB2, TGFB1, TGFB3, SMAD7, SMAD2, SMAD3
26adenocarcinoma10.0TGFB2, TGFB1, TGFBR1, TGFB3, SMAD7, SMAD2
27squamous cell carcinoma10.0TGFB2, TGFB1, TGFBR1, TGFB3, SMAD7, SMAD2
28melanoma10.0TGFB2, TGFB1, TGFB3, SMAD2, SMAD3, KRT14
29lung cancer10.0TGFB2, TGFBR1, SMAD7, SMAD2, SMAD3, KRT14
30hypertrophy of breast10.0TGFB1, TGFBR1, TGFB3, SMAD2, SMAD3, MMP13
31breast cancer10.0TGFB1, TGFBR1, TGFB3, SMAD2, KRT14, MMP13
32osteoarthritis10.0TGFB2, TGFB1, TGFB3, MMP8, MMP13, CD36
33hepatocellular carcinoma10.0TGFB2, TGFB1, TGFBR1, SMAD7, SMAD2, SMAD3
34atherosclerosis10.0TGFB1, MMP8, MMP13, CD36, DCN, DDR1
35osteosarcoma10.0TGFB2, TGFB1, TGFB3, MMP13, CD36, DCN
36malignant glioma10.0TGFB2, SMAD7, SMAD2, SMAD3, DCN, DDR1
37focal segmental glomerulosclerosis10.0TGFB1, SMAD2, SMAD3, SERPINH1, CD36, DCN
38asthma10.0TGFB1, TGFB3, SMAD7, SMAD2, MMP8, DCN
39diabetic nephropathy10.0TGFB1, TGFBR1, SMAD7, SMAD3, CD36, DCN
40glomerulonephritis10.0TGFB1, TGFBR1, SMAD7, SMAD2, SERPINH1, DCN
41rheumatoid arthritis10.0SERPINH1, MMP8, MMP13, CD36, DCN, BMP6
42squamous cell carcinoma of the head and neck10.0TGFB1, TGFBR1, SMAD2, SMAD3, KRT14, MMP13
43colon cancer10.0TGFB2, TGFB1, TGFBR1, SMAD2, DCN, DDR1
44idiopathic pulmonary fibrosis10.0TGFB1, SERPINH1, CD36, DDR1, BMP6, CTGF
45glioblastoma multiforme10.0TGFB2, TGFB1, DCN, DDR1, BMP6, TNC
46osteoporosis10.0TGFB1, SMAD2, SMAD3, MMP8, MMP13, CD36
47leukemia10.0TGFB1, TGFBR1, SMAD2, SMAD3, KRT14, BMP6
48stomach cancer10.0TGFB1, TGFBR1, TGFB3, SMAD7, SMAD2, BMP6
49vascular disease10.0TGFBR1, DCN, BMP6, CTGF, TNC, TIMP2
50ovarian cancer10.0TGFB2, TGFBR1, TGFB3, SMAD2, MMP13, DCN

Graphical network of the top 20 diseases related to Keloids:



Diseases related to keloids

Clinical Features for Keloids

Drugs & Therapeutics for Keloids

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Keloids

Drug clinical trials:

Search ClinicalTrials for Keloids

Search NIH Clinical Center for Keloids

Search CenterWatch for Keloids

Genetic Tests for Keloids

Sources:
20GeneTests
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Genetic tests related to Keloids:

id Genetic test Affiliating Genes
1 Keloids20

Anatomical Context for Keloids

Sources:
33MalaCards
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MalaCards organs/tissues related to Keloids:

33
Kidney, Breast, Skin, T cells, Endothelial

Animal Models for Keloids or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Keloids:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538511.3MMP13, CD36, DDR1, CTGF, LOX, SERPINH1
2MP:000537611.3TGFBR1, LOX, TNC, CTGF, DCN, CD36
3MP:000538411.3MMP13, CD36, DCN, DDR1, CTGF, KRT14
4MP:000537811.3CD36, DCN, DDR1, BMP6, CTGF, MMP13
5MP:001076811.2LOX, CTGF, DCN, CD36, KRT14, SERPINH1
6MP:000539011.2CD36, DCN, DDR1, CTGF, MMP13, SERPINH1
7MP:000538711.2MMP8, CD36, DCN, DDR1, TIMP2, KRT14
8MP:000538811.2KRT14, DCN, CTGF, LOX, SERPINH1, SMAD2
9MP:001077111.2LOX, CTGF, DCN, MMP13, KRT14, SMAD3
10MP:000538111.2KRT14, CD36, DCN, CTGF, SERPINH1, SMAD3
11MP:000538211.1CTGF, DDR1, DCN, SERPINH1, SMAD3, SMAD2
12MP:000538011.0CTGF, DDR1, SERPINH1, SMAD3, SMAD2, TGFB3
13MP:000538911.0BMP6, DDR1, DCN, KRT14, SMAD3, SMAD2
14MP:000538611.0LOX, TIMP2, TNC, DCN, CD36, SMAD3
15MP:000539110.9DCN, KRT14, SMAD2, TGFB3, TGFB2
16MP:000200610.9DCN, MMP8, KRT14, SMAD3, SMAD2, TGFBR1
17MP:000539710.8DDR1, DCN, CD36, SMAD3, SMAD2, SMAD7
18MP:000363110.7TIMP2, TNC, SERPINH1, TGFB1
19MP:000537910.6TGFB1, SMAD2, SMAD3, DCN
20MP:000536910.4TGFB2, LOX, DCN, CD36, SMAD7, TGFB1
21MP:000537110.4SERPINH1

Publications for Keloids

Sources:
51PubMed
See all sources

Articles related to Keloids:

(show top 50)    (show all 544)
idTitleAuthorsYear
1
Recurrent Auricular Keloids during Pregnancy. (23362485)
2013
2
Analysis of 15 cases of auricular keloids following conchal cartilage grafts in an asian population. (23161161)
2013
3
The use of the 300 microsecond 1064 nm Nd:YAG laser in the treatment of keloids. (24196333)
2013
4
A comparative clinical study on role of 5-flurouracil versus triamcinolone in the treatment of keloids. (23904725)
2012
5
Letter regarding "management of ear lobule keloids using 980-nm diode laser". (22484553)
2012
6
Pain evaluation and control during and following the treatment of hypertrophic scars and keloids by contact and intralesional cryosurgery--a preliminary study. (21557777)
2012
7
The treatment of keloids with pneumatic technology: a pilot study. (23171019)
2012
8
Advances in the treatment of keloids. (21533292)
2011
9
Keloids can be forced into remission with surgical excision and radiation, followed by adjuvant therapy. (21407049)
2011
10
The most current algorithms for the treatment and prevention of hypertrophic scars and keloids. (20811265)
2010
11
Keloids show regional distribution of proliferative and degenerate connective tissue elements. (19641294)
2010
12
The efficacy of silicone gel for the treatment of hypertrophic scars and keloids. (20808600)
2009
13
What factors affect the quality of life of patients with keloids? (20191224)
2009
14
Chronologic change of the maximum dimension of Bacillus Calmette-Guerin-induced keloids. (19215254)
2009
15
Management of keloids and hypertrophic scars. (19621835)
2009
16
Dose-response relationship and dose optimization in radiotherapy of postoperative keloids. (19201502)
2009
17
A prospective clinical review of "multi model" approach for treating ear keloids. (19753193)
2008
18
Pustular psoriasis over keloids: is it a Koebner phenomenon? (16716179)
2006
19
New technique for injecting corticosteroid in keloids scarring. (16557093)
2006
20
Ineffective treatment of keloids with interferon alpha-2b. (16404275)
2006
21
Elevated vascular endothelial growth factor in keloids: relevance to tissue fibrosis. (14745238)
2004
22
Treatment of earlobe keloids using the cobalt 60 teletherapy unit. (15166996)
2004
23
Fibrillin-1 and elastin are differentially expressed in hypertrophic scars and keloids. (15086768)
2004
24
Hypertrophic scars and keloids: etiology and management. (12680802)
2003
25
New therapies for the management of keloids. (14501323)
2003
26
Painless steroid injections for hypertrophic scars and keloids. (12479437)
2002
27
Zimmer splintage: a simple effective treatment for keloids following ear-piercing. (11513513)
2001
28
The body's skin frontier and the challenges of wound healing: keloids. (10715928)
2000
29
Keloids and hypertrophic scars: results with intraoperative and serial postoperative corticosteroid injection therapy. (10515339)
1999
30
Two patients with penile keloids: a review of the literature. (9418933)
1997
31
Functional analyses of the stratum corneum in scars. Sequential studies after injury and comparison among keloids, hypertrophic scars, and atrophic scars. (8961874)
1996
32
Proliferating activity of dermal fibroblasts in keloids and hypertrophic scars. (7604635)
1995
33
The protruding scars: keloids and hypertrophic diagnosis and treatment with silicon-gel-sheeting. (7971533)
1994
34
Earlobe keloids. (8203321)
1994
35
Regulation of collagen gene expression in keloids and hypertrophic scars. (8412102)
1993
36
Topical silicone gel sheeting in the treatment of hypertrophic scars and keloids. A dermatologic experience. (8408909)
1993
37
Keloids of the external ear. (1377373)
1992
38
Altered cytokine production in black patients with keloids. (1512303)
1992
39
Keloids. (1779193)
1991
40
The effect of carbon dioxide laser surgery on the recurrence of keloids. (1898535)
1991
41
Single-dose electron beam irradiation in treatment and prevention of keloids and hypertrophic scars. (2126387)
1990
42
Hypertrophic scars and keloids. Cause and management--current concepts. (3055354)
1988
43
Wide spread scars, hypertrophic scars, and keloids. (3581659)
1987
44
Immunoglobulins in hypertrophic scars and keloids. (6344114)
1983
45
Structure of the collagen nodule from hypertrophic scars and keloids. (7330586)
1981
46
Rubinstein-Taybi syndrome. Cutaneous manifestations and colossal keloids. (7259246)
1981
47
HLA antigens in keloids and hypertrophic scars. (596911)
1977
48
Biologic basis for the treatment of keloids and hypertrophic scars. (5427162)
1970
49
Differential diagnosis of keloids and hypertrophic scars by tissue culture technique with notes on therapy of keloids by surgical excision and decadron. (13811659)
1960
50
Hypertrophic scars and keloids. (13008023)
1953

Genetic Variations for Keloids

Expression for genes affiliated with Keloids

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Keloids

Search GEO for disease gene expression data for Keloids.

Pathways for genes affiliated with Keloids

Sources:
52QIAGEN, 30KEGG, 54Reactome, 38NCBI BioSystems Database, 56SinoBiological, 53R&D Systems, 4Cell Signaling Technology, 12EMD Millipore
See all sources

Pathways related to Keloids according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9CTGF, TIMP2, TGFB2, TGFBR1, TGFB3, MMP8
2
Hide members
10.8CTGF, TIMP2, TNC, TGFB1, BMP6, DDR1
310.8BMP6, DCN, TGFB1, TGFBR1, TGFB3, SMAD7
4
Hide members
10.8CTGF, TGFB3, TGFBR1, TGFB1, TIMP2, BMP6
5
Hide members
10.8TNC, DDR1, MMP13, LOX, MMP8, SERPINH1
610.8SMAD3, TGFB3, SMAD2, SMAD7, TGFB2, TGFBR1
710.8TGFB2, TGFBR1, SMAD2, TGFB1, SMAD3, TGFB3
810.8SMAD3, CTGF, SMAD7, SMAD2, TGFB3, TGFBR1
910.8SMAD3, SMAD2, SMAD7, CTGF, TGFB1, TGFB3
10
Hide members
10.7TGFB2, TGFB1, DDR1, BMP6, CTGF, TIMP2
11
Hide members
10.7TGFB2, TGFB1, TGFBR1, TGFB3, BMP6, TIMP2
12
Hide members
10.7TIMP2, BMP6, DDR1, TGFB3, TGFB1, CTGF
1310.7TGFB3, DCN, TGFB2, TGFB1, TGFBR1, SMAD2
14
Hide members
10.7TGFB2, TGFBR1, TGFB3, SMAD2, SMAD3, TGFB1
1510.7TGFB3, TGFBR1, TGFB1, SMAD2, SMAD3, TGFB2
1610.7SMAD2, TGFB3, SMAD3, TGFBR1, TGFB1, TGFB2
17
Hide members
10.7TIMP2, CTGF, TGFB1, TGFB2, TGFB3, BMP6
1810.7TGFB1, TGFB2, TGFBR1, TGFB3, TIMP2, TNC
19
Hide members
10.7BMP6, CTGF, TGFB1, TGFBR1, TGFB3, TIMP2
20
Hide members
10.7CD36, TGFB3, DDR1, DCN, TNC
2110.7TGFB3, TGFB2, TGFB1, TGFBR1, BMP6
2210.7TGFB2, SERPINH1, MMP13, TGFB1, BMP6
23
Hide members
10.7TGFBR1, SMAD2, SMAD7, TGFB1, SMAD3
24
Development TGF-beta receptor signaling
Hide members
10.7TGFB1, TGFBR1, SMAD2, SMAD3, SMAD7
25
Hide members
10.7CTGF, BMP6, TGFB3, TNC, TGFBR1
26
Hide members
10.6LOX, TGFB2, TGFB1, TGFB3
27
Hide members
10.6TGFB2, TGFB1, TGFB3, TGFBR1
28
Hide members
10.6TGFB2, TGFB3, TGFBR1, TGFB1
2910.6TGFB3, TGFB2, TGFB1, TGFBR1
3010.6TGFBR1, SMAD7, TGFB1, TGFB3
3110.6TGFB2, TGFB1, TGFBR1, MMP13
32
Hide members
10.6SMAD3, SMAD2, TGFB3, TGFBR1
33
Cytokine production by Th17 cells in CF (Mouse model)
10.6TGFBR1, SMAD2, SMAD3, TGFB1
3410.6SMAD2, TGFBR1, TGFB3
35
Hide members
10.6SMAD3, TGFB3, SMAD2
3610.6TGFBR1, SMAD7, SMAD2
37
Hide members
10.6CTGF, DDR1, TGFBR1
38
Hide members
10.6CTGF, TIMP2, DDR1
3910.6SMAD3, TGFBR1, SMAD2
40
Cell cycle Cell cycle (generic schema)
Hide members
10.6SMAD3, SMAD2, TGFBR1
41
Hide members
10.6TGFBR1, TGFB3
42
Hide members
10.6TGFB3, TGFBR1
43
Hide members
10.6TGFB3, SMAD3
4410.5TGFB3
4510.5TGFB3
46
Hide members
10.5TGFB3
4710.5SMAD7
48
Hide members
10.5DDR1
49
Hide members
10.5TGFBR1
50
Hide members
10.5TGFBR1

Compounds for genes affiliated with Keloids

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Keloids according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1vegf4511.6TGFB2, TGFB1, TGFBR1, TGFB3, SMAD7, SMAD2
2oligonucleotide4511.5TGFB2, TGFBR1, TGFB3, SMAD7, SMAD2, SMAD3
3retinoic acid45 2412.5BMP6, MMP13, MMP8, CD36, CTGF, TNC
4matrigel4511.4MMP13, SMAD3, SMAD2, SMAD7, TGFBR1, TGFB2
5tgf beta14511.4BMP6, CTGF, TNC, DCN, MMP13, TGFB2
6dexamethasone45 50 29 1114.4BMP6, LOX, DCN, MMP13, CTGF, TGFB2
7glycosaminoglycan4511.3CD36, DCN, BMP6, TNC, TIMP2, LOX
8tyrosine4511.3TGFBR1, TGFB3, SMAD7, TGFB2, TNC, SMAD2
9paraffin4511.3TGFB2, TNC, TIMP2, DCN, CD36, MMP13
10ribonucleic acid4511.3TGFBR1, TIMP2, CTGF, BMP6, DDR1, DCN
11cysteine4511.3KRT14, TGFB2, SMAD2, MMP8, CD36, DCN
12hydroxyproline45 11 2413.3DCN, CD36, MMP13, SMAD7, TGFB1, BMP6
13thymidine45 2412.3TGFB2, TGFB1, TGFB3, LOX, TIMP2, SMAD3
14nitric oxide45 11 2413.2TGFB3, SMAD2, SMAD3, SERPINH1, MMP8, MMP13
15glucose4511.2TGFB2, KRT14, TGFBR1, LOX, TIMP2, CTGF
16sb 20358045 6012.2TIMP2, CD36, SMAD3, SMAD2, BMP6, CTGF
17pd 98,0594511.2TIMP2, CTGF, BMP6, DCN, MMP13, SMAD3
18bleomycin45 1112.2LOX, TGFB1, SMAD7, SMAD2, SMAD3, DCN
19ly2940024511.2BMP6, CTGF, TNC, TGFBR1, SMAD2, SMAD3
20serine4511.2TIMP2, TGFB1, CTGF, TGFBR1, MMP13, MMP8
21hyaluronic acid45 2412.2BMP6, TGFB2, MMP13, CD36, TNC, TIMP2
22alanine4511.1TIMP2, DCN, TGFB1, TGFBR1, SMAD2, SMAD3
23heparin45 29 11 2414.1CTGF, DCN, TIMP2, MMP13, TGFBR1, BMP6
24ascorbic acid45 2412.1LOX, TNC, CD36, MMP13, SERPINH1, TGFB2
25progesterone45 60 29 11 2415.1TIMP2, TNC, BMP6, MMP8, KRT14, TGFB3
26losartan45 50 29 1114.1TGFB1, CD36, SMAD2, TIMP2, CTGF, BMP6
27cyclosporin a45 29 6013.1TGFB2, SERPINH1, DCN, CTGF, TIMP2, MMP8
28h2o24511.1CTGF, CD36, MMP8, SMAD2, LOX, TIMP2
29genistein45 29 60 2 11 2416.0MMP13, DCN, TIMP2, CD36, TGFB2, TGFBR1
30dihydrotestosterone45 29 11 2414.0TGFBR1, BMP6, TGFB2, TGFB1, SMAD2, SMAD3
31creatinine4511.0TGFB2, TIMP2, BMP6, DCN, CD36, TGFB1
32alginate4511.0TGFB3, MMP13, CD36, DCN
33lysine4511.0LOX, SMAD3, TIMP2, DCN, KRT14, SMAD7
34n acetylcysteine4511.0LOX, TGFB2, SMAD7, SMAD2, SMAD3, CTGF
35procollagen4511.0TGFB1
36lipid4511.0MMP8, TIMP2, CTGF, SMAD3, TGFB3, TGFBR1
37chondroitin sulfate45 2412.0BMP6, CD36, MMP13, DCN, TNC
38pge24510.9TGFB1
39vitamin d4510.9KRT14, TGFB2, TGFB1, CD36, BMP6, SMAD3
40(4-aminophenyl)mercuric acetate4510.9MMP13, MMP8
41p0024510.9CTGF, MMP8, MMP13, TNC, TIMP2
42alendronate45 50 1112.9MMP13, MMP8, TIMP2, CD36
43batimastat45 60 1112.8TIMP2, CD36, MMP13, MMP8
44tranilast4510.8BMP6, SMAD2, TGFB1
45hydroxyapatite4510.7MMP13, CD36, CTGF, DCN
46ccl445 2911.7TGFB3, MMP13
474-hydroxytamoxifen4510.6TGFB2, TGFB1, TGFB3, BMP6
48pirfenidone45 6011.6BMP6, CD36, TGFB1
49gnrh4510.5SMAD3, SMAD7, TGFB3, DCN
50lactate4510.4MMP8, BMP6, CTGF, TIMP2, LOX, TGFB1

GO Terms for genes affiliated with Keloids

Sources:
16Gene Ontology
See all sources

Cellular components related to Keloids according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.1MMP13, TGFB1, TGFB3, SERPINH1, MMP8, DCN
2extracellular regionGO:00557611.0TGFB2, TGFB1, TGFB3, MMP8, MMP13, DCN
3extracellular matrixGO:03101210.7DCN, TNC, TGFB3, TGFB2
4neuronal cell bodyGO:04302510.6TGFB1, TGFB3, TIMP2, TGFB2
5SMAD protein complexGO:07114110.6SMAD2, SMAD3
6platelet alpha granule lumenGO:03109310.5TGFB2, TGFB1, TGFB3
7proteinaceous extracellular matrixGO:00557810.3CTGF, MMP13, MMP8, TGFB1

Biological processes related to Keloids according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019811.4DCN, LOX, SERPINH1, TGFB3, TNC, DDR1
2transforming growth factor beta receptor signaling pathwayGO:00717911.2TGFBR1, TGFB1, TGFB2, SMAD2, SMAD3, TGFB3
3negative regulation of transforming growth factor beta receptor signaling pathwayGO:03051211.2TGFBR1, SMAD2, SMAD7, TGFB1, TGFB3, SMAD3
4positive regulation of epithelial to mesenchymal transitionGO:01071811.1SMAD3, SMAD2, TGFB3, TGFB1, TGFB2
5wound healingGO:04206011.1DCN, SMAD3, TGFBR1, LOX, TGFB2
6negative regulation of cell proliferationGO:00828511.1DDR1, SMAD2, TGFB3, TGFB1, TGFB2, TIMP2
7pathway-restricted SMAD protein phosphorylationGO:06038911.1SMAD7, TGFBR1, TGFB1, TGFB2
8regulation of transforming growth factor beta receptor signaling pathwayGO:01701511.1SMAD3, SMAD2, SMAD7, TGFB1
9positive regulation of protein secretionGO:05071411.1TGFB3, BMP6, TGFB2, TGFB1
10positive regulation of pathway-restricted SMAD protein phosphorylationGO:01086211.1TGFBR1, BMP6, TGFB3, TGFB1
11positive regulation of bone mineralizationGO:03050111.1TGFB1, BMP6, SMAD3, TGFB3
12ureteric bud developmentGO:00165711.1TGFB1, SMAD3, SMAD2, SMAD7
13collagen fibril organizationGO:03019911.0SERPINH1, TGFB2, TGFBR1, LOX
14negative regulation of macrophage cytokine productionGO:01093611.0TGFB2, TGFB1, TGFB3
15response to woundingGO:00961111.0TGFB2, TGFB1, CTGF, TNC
16cell-cell junction organizationGO:04521611.0SMAD3, TGFB2, TGFB3, TGFB1
17platelet degranulationGO:00257611.0CD36, TGFB1, TGFB3, TGFB2
18salivary gland morphogenesisGO:00743511.0TGFB2, TGFB1, TGFB3
19regulation of bindingGO:05109811.0TGFB1, SMAD2, SMAD3
20response to laminar fluid shear stressGO:03461611.0TGFB1, TGFB3, SMAD7
21SMAD protein import into nucleusGO:00718411.0TGFB3, TGFB1, TGFB2
22response to cholesterolGO:07072311.0TGFBR1, SMAD2, TGFB1
23agingGO:00756811.0DCN, TGFB3, TIMP2, TGFB1
24positive regulation of SMAD protein import into nucleusGO:06039111.0TGFB3, TGFBR1, TGFB1
25SMAD protein complex assemblyGO:00718311.0TGFB1, SMAD3, SMAD2
26positive regulation of collagen biosynthetic processGO:03296711.0TGFB3, TGFB1, CTGF
27negative regulation of mitotic cell cycleGO:04593011.0TIMP2, SMAD3, TGFB1
28response to progesterone stimulusGO:03257011.0TGFB1, TGFB2, TGFB3
29cell cycle arrestGO:00705010.9TGFBR1, TGFB1, TGFB2, SMAD3
30positive regulation of gene expressionGO:01062810.9CTGF, TGFB2, TGFB1, TNC
31extrinsic apoptotic signaling pathwayGO:09719110.9TGFB1, SMAD3, TGFB2
32embryonic cranial skeleton morphogenesisGO:04870110.9TGFBR1, SMAD3, SMAD2
33face morphogenesisGO:06032510.9TGFB3, TGFB1, TGFB2
34epithelial to mesenchymal transitionGO:00183710.9TGFB2, TGFBR1, TGFB1
35response to hypoxiaGO:00166610.9TGFB1, TGFB3, TGFB2, SMAD3
36evasion or tolerance of host defenses by virusGO:01904910.9SMAD3, TGFB1
37positive regulation of transcription from RNA polymerase II promoterGO:04594410.9TGFB3, SMAD2, SMAD7, SMAD3, TGFB1, BMP6
38paraxial mesoderm morphogenesisGO:04834010.8SMAD2, SMAD3
39ossification involved in bone remodelingGO:04393210.8TGFB3, TGFB1
40regulation of transforming growth factor beta2 productionGO:03290910.8SMAD3, TGFB2
41positive regulation of cell divisionGO:05178110.8TGFB1, TGFB2, TGFB3
42frontal suture morphogenesisGO:06036410.8TGFB1, TGFB3
43menstrual cycle phaseGO:02260110.8TGFB3, TGFB2
44regulation of striated muscle tissue developmentGO:01620210.7TGFB1, SMAD3
45positive regulation of cell proliferationGO:00828410.7CTGF, TGFB1, TNC, TGFB2, TGFBR1
46cell growthGO:01604910.7TGFB3, TGFB1, TGFB2
47primary miRNA processingGO:03105310.7SMAD2, SMAD3
48common-partner SMAD protein phosphorylationGO:00718210.6TGFB1, SMAD2
49transcription initiation from RNA polymerase II promoterGO:00636710.5SMAD2, CTGF, SMAD3, SMAD7
50nodal signaling pathwayGO:03809210.3SMAD2, SMAD3

Molecular functions related to Keloids according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1collagen bindingGO:00551810.8DDR1, DCN, SERPINH1, SMAD3, SMAD7
2type II transforming growth factor beta receptor bindingGO:00511410.8TGFB2, TGFB1, TGFBR1, TGFB3
3type I transforming growth factor beta receptor bindingGO:03471310.8TGFB3, SMAD7, SMAD2
4growth factor activityGO:00808310.7CTGF, BMP6, TGFB3, TGFB1, TGFB2
5I-SMAD bindingGO:07041110.7SMAD2, SMAD7, TGFBR1
6transforming growth factor beta bindingGO:05043110.6CD36, TGFB3, TGFBR1
7co-SMAD bindingGO:07041010.6SMAD2, SMAD3
8transforming growth factor beta receptor bindingGO:00516010.5SMAD3, SMAD2, TGFB2
9transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activityGO:03061810.3SMAD2, SMAD3

Products for genes affiliated with Keloids

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Keloids

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet