MCID: KLD001
MIFTS: 34

Keloids malady

Genetic diseases (common) category

Summaries for Keloids

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66Wikipedia, 34MalaCards
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Wikipedia:66 A keloid (/?ki?l??d/; also keloidal scar) is the formation of a type of scar which, depending on its... more...

MalaCards: Keloids, also known as keloid, is related to hypertrophic scars and keloid formation. An important gene associated with Keloids is MIR196A2 (microRNA 196a-2). Affiliated tissues include skin, endothelial and breast.

Aliases & Classifications for Keloids

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21GeneTests, 46Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Aliases & Descriptions:

keloids 21
keloid 46


Related Diseases for Keloids

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Keloids:



Diseases related to keloids

Symptoms for Keloids

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Drugs & Therapeutics for Keloids

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Keloids

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21GeneTests
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Genetic tests related to Keloids:

id Genetic test Affiliating Genes
1 Keloids21

Anatomical Context for Keloids

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34MalaCards
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MalaCards organs/tissues related to Keloids:

34
Skin, Endothelial, Breast, Kidney, Lymph node, Eye, Smooth muscle, T cells

Animal Models for Keloids or affiliated genes

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Publications for Keloids

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53PubMed
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Articles related to Keloids:

(show top 50)    (show all 761)
idTitleAuthorsYear
1
Reply: Outcomes of surgical excision with pressure therapy using magnets and identification of risk factors for recurrent keloids. (24076718)
2013
2
Comparative efficacy of intralesional verapamil hydrochloride and triamcinolone acetonide in hypertrophic scars and keloids. (24182692)
2013
3
Pharmacological treatment for keloids. (23937443)
2013
4
Clinical features and outcomes of foot keloids treated using complete surgical excision and full thickness skin grafting followed by corticosteroid injections. (23856363)
2013
5
New pressure device, "Magsil," as an adjuvant pressure therapy for ear keloids. (22801801)
2012
6
Nodular scleroderma presenting as multiple spontaneous keloidal scars. (22583729)
2012
7
A comparative clinical study on role of 5-flurouracil versus triamcinolone in the treatment of keloids. (23904725)
2012
8
Upregulation of Toll-like receptors (TLRs) 6, 7, and 8 in keloid scars. (21677671)
2011
9
Surgical excision and immediate postoperative radiotherapy versus cryotherapy and intralesional steroids in the management of keloids: a prospective clinical trial. (20639666)
2010
10
Earlobe keloids: emerging cosmetic complication of ear-piercing. (21243860)
2010
11
Increased expression of fibroblast activation protein-alpha in keloid fibroblasts: implications for development of a novel treatment option. (20872224)
2010
12
Hepatoma-derived growth factor and its role in keloid pathogenesis. (19432814)
2010
13
Postoperative strontium-90 brachytherapy in the prevention of keloids: results and prognostic factors. (19101094)
2009
14
Unusual formation of keloids after each episode of recurrent herpes zoster in an HIV positive patient. (21938132)
2009
15
Keloidoscope: in search for the ideal treatment of keloids. (23139545)
2009
16
Matrix metalloproteinase-2 and -9 activities in human keloids, hypertrophic and atrophic scars: a pilot study. (19165813)
2009
17
Is radiation therapy for keloids acceptable? The risk of radiation-induced carcinogenesis. (19935303)
2009
18
A custom-made silicon mold for pressure therapy to ear keloids. (19322608)
2009
19
Isolation and characterization of multipotent human keloid-derived mesenchymal-like stem cells. (18710345)
2008
20
Correlation analysis between clinical phenotypes of keloids and polymorphism of p53 gene codon 72]. (19137883)
2008
21
Descriptive study of patients receiving excision and radiotherapy for keloids. (18249504)
2008
22
Keloids do not harbor EBV or HHV8. (17689878)
2008
23
Keloids: A viral hypothesis. (17509771)
2008
24
Abnormal nuclear factor (NF)-kappaB signal pathway and aspirin inhibits tumor necrosis factor alpha-induced NF-kappaB activation in keloid fibroblasts. (17550447)
2007
25
Effect of heat shock protein 47 on collagen accumulation in keloid fibroblast cells. (17535221)
2007
26
Factor XIIIa-positive dermal dendritic cells in keloids and hypertrophic and mature scars. (17539964)
2007
27
Trisomy 9p associated with self-injured behaviour and multiple intractable keloids. (16922967)
2006
28
Pseudopterygium arising in a patient with multiple keloids. (16491728)
2006
29
Expressions of TGF-betaR I, Smad2, Smad3 and Smad7 in keloids]. (17144456)
2006
30
Gene expression patterns in isolated keloid fibroblasts. (16939575)
2006
31
Modulation of collagen synthesis in keloid fibroblasts by silencing Smad2 with siRNA. (17051103)
2006
32
Genetic susceptibility to keloid disease: mutation screening of the TGFbeta3 gene. (16043141)
2005
33
Activated caspase expression and apoptosis increase in keloids: cytochrome c release and caspase-9 activation during the apoptosis of keloid fibroblast lines. (16008726)
2005
34
Treatment of hypertrophic scars and keloids with a radiofrequency device: a study of collagen effects. (16365887)
2005
35
Pathological genomics of keloid fibroblastic cells]. (16248530)
2005
36
Retrospective analysis of treatment of unresectable keloids with primary radiation over 25 years. (15214654)
2004
37
Mechanisms of hypoxic regulation of plasminogen activator inhibitor-1 gene expression in keloid fibroblasts. (14708599)
2003
38
Phosphorylation of extracellular signal-regulated protein kinase in cultured keloid fibroblasts when stimulated by platelet-derived growth factor BB. (15328769)
2003
39
Painless steroid injections for hypertrophic scars and keloids. (12706172)
2003
40
Fibrodysplasia ossificans progressiva and corneal keloid. (12352096)
2002
41
Zimmer splintage: a simple effective treatment for keloids following ear-piercing. (11513513)
2001
42
Aetiopathogenesis of keloids. (10862278)
1999
43
Altered posttranslational modifications of collagen in keloid. (9731191)
1998
44
Failure of interferon-alpha 2b in the treatment of mature keloids. (8809610)
1996
45
The protruding scars: keloids and hypertrophic diagnosis and treatment with silicon-gel-sheeting. (7971533)
1994
46
Regulation of collagen gene expression in keloids and hypertrophic scars. (8412102)
1993
47
Treatment of keloids by 90Sr-90Y beta-rays. (1858015)
1991
48
Intralesional interferon gamma treatment for keloids and hypertrophic scars. (2119626)
1990
49
Treatment of keloids and hypertrophic scars with an argon laser. (3959718)
1986
50
Follow-up on treatment of hypertrophic scars and keloids with triamcinolone. (5566476)
1971

Variations for Keloids

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Expression for genes affiliated with Keloids

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keloids

Search GEO for disease gene expression data for Keloids.

Pathways for genes affiliated with Keloids

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Compounds for genes affiliated with Keloids

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GO Terms for genes affiliated with Keloids

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17Gene Ontology
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Biological processes related to Keloids according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ovarian follicle developmentGO:0015419.6FOXL2, MMP19
2cell differentiationGO:0301549.5FOXL2, MMP19, TNFSF12

Products for genes affiliated with Keloids

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Sources for Keloids

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet