Aliases & Classifications for Keloids

Aliases & Descriptions for Keloids:

Name: Keloids 38 24
Keloid Disorder 71 29
Keloid 52

Characteristics:

HPO:

32
keloids:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Keloids

MalaCards based summary : Keloids, also known as keloid disorder, is related to torticollis, keloids, cryptorchidism, and renal dysplasia and keloid formation. An important gene associated with Keloids is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways are Integrin Pathway and Toll-like Receptor Signaling Pathway. The drugs Triamcinolone and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and breast, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 71 Keloid, also known as keloid disorder and keloidal scar, is the formation of a type of scar which,... more...

Related Diseases for Keloids

Diseases related to Keloids via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
id Related Disease Score Top Affiliating Genes
1 torticollis, keloids, cryptorchidism, and renal dysplasia 12.0
2 keloid formation 12.0
3 x-linked keloid scarring-reduced joint mobility-increased optic cup-to-disc ratio syndrome 11.8
4 hypertrophic scars 11.5
5 lobomycosis 11.2
6 premature aging syndrome, penttinen type 11.1
7 diffuse large b-cell lymphoma 10.2 MMP1 TGFB1
8 akinetic mutism 10.2 CD36 SMAD2
9 catecholaminergic polymorphic ventricular tachycardia 10.1 MMP1 TGFB1
10 ovarian insufficiency, familial 10.1 CD36 TGFB1
11 cartilage disease 10.1 FAS TGFB1
12 ovarian insufficiency due to fsh resistance 10.1 CD36 TGFB1
13 cervix uteri carcinoma in situ 10.1 FAS TGFB1
14 linear porokeratosis 10.1 MMP1 TNC
15 hereditary night blindness 10.1 MMP1 SMAD3 TGFB1
16 noonan syndrome 4 10.1 CD36 MMP1 TGFB1
17 zika fever 10.0 CD36 MMP1 TGFB1
18 germ cell and embryonal cancer 10.0 CD36 MMP1 TGFB1
19 osteonecrosis 10.0 MMP1 SMAD3 TGFB1
20 intellectual developmental disorder with persistence of fetal hemoglobin 10.0 SMAD3 TGFB3
21 endotheliitis 10.0
22 onychocytic matricoma 10.0 CD36 MMP1
23 discharging ear 10.0 TGFB1 TGFB3
24 idiopathic corneal edema 10.0 MMP1 TNC
25 in situ pulmonary adenocarcinoma 10.0 MMP1 TGFB1 TNC
26 trabecular follicular adenocarcinoma 10.0 FAS TNC
27 rubinstein-taybi syndrome 10.0
28 upper respiratory tract disease 10.0 SMAD2 TGFB1
29 syndactyly 9.9
30 endemic typhus 9.9 SMAD3 TGFB1 TGFB3
31 pasteurellosis 9.9 MMP1 TGFB3
32 pulmonary valve insufficiency 9.9 SMAD2 SMAD3 SMAD7 TGFB1
33 neuroectodermal endocrine syndrome 9.9 SMAD2 SMAD3 SMAD7 TGFB1
34 acute necrotizing encephalitis 9.9 SMAD2 SMAD3 SMAD7 TGFB1
35 acne 9.9
36 blastomycosis 9.8
37 burns 9.8
38 vibratory urticaria 9.8 SMAD2 SMAD3 TGFB1 TGFB3
39 leiomyoma 9.7
40 myopathy 9.7
41 scar contracture 9.7
42 insulin-like growth factor i 9.7
43 herpes zoster 9.7
44 dermatitis 9.7
45 psoriasis 9.7
46 hemorrhagic cystitis 9.7 CD36 SMAD2 SMAD3 SMAD7 TGFB1
47 lubani-al saleh-teebi syndrome 9.7 SMAD3 SMAD7 TGFB1 TGFB3
48 gingivitis 9.7
49 fibrosarcoma 9.7
50 anterior segment mesenchymal dysgenesis 9.7

Graphical network of the top 20 diseases related to Keloids:



Diseases related to Keloids

Symptoms & Phenotypes for Keloids

Human phenotypes related to Keloids:

32
id Description HPO Frequency HPO Source Accession
1 keloids 32 HP:0010562

MGI Mouse Phenotypes related to Keloids:

44 (show all 15)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.15 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
2 cardiovascular system MP:0005385 10.08 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
3 cellular MP:0005384 10.07 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
4 homeostasis/metabolism MP:0005376 10.06 CD36 FAS MMP1 SMAD2 SMAD3 SMAD7
5 digestive/alimentary MP:0005381 10.04 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
6 growth/size/body region MP:0005378 10 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
7 craniofacial MP:0005382 9.99 FAS SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
8 hematopoietic system MP:0005397 9.98 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
9 immune system MP:0005387 9.97 TGFB1 TGFB3 CD36 FAS MMP1 SMAD2
10 endocrine/exocrine gland MP:0005379 9.95 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
11 liver/biliary system MP:0005370 9.72 CD36 FAS SMAD2 SMAD3 TGFB1
12 nervous system MP:0003631 9.7 SMAD2 SMAD3 TGFB1 TGFB3 TNC CD36
13 neoplasm MP:0002006 9.65 FAS MMP1 SMAD2 SMAD3 TGFB1
14 skeleton MP:0005390 9.43 CD36 FAS SMAD2 SMAD3 TGFB1 TGFB3
15 vision/eye MP:0005391 9.1 CD36 FAS SMAD2 SMAD3 TGFB1 TGFB3

Drugs & Therapeutics for Keloids

Drugs for Keloids (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 92)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 1 124-94-7 31307
2
Fluorouracil Approved Phase 4,Early Phase 1 51-21-8 3385
3
Ethanol Approved Phase 4 64-17-5 702
4
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
5
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
6
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
7
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
8
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
9
Tetracaine Approved, Vet_approved Phase 4 94-24-6 5411
10
Prilocaine Approved Phase 4 721-50-6 4906
11
Petrolatum Approved Phase 4 8009-03-8
12
Verapamil Approved Phase 4 52-53-9 2520
13
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
14
Butyric Acid Experimental Phase 4 107-92-6 264
15 triamcinolone acetonide Phase 4,Phase 3,Phase 1
16 glucocorticoids Phase 4,Phase 3,Phase 1
17 Hormone Antagonists Phase 4,Phase 3,Phase 1
18 Anesthetics Phase 4
19 Triamcinolone diacetate Phase 4,Phase 3,Phase 1
20 Triamcinolone hexacetonide Phase 4,Phase 3,Phase 1
21 Hormones Phase 4,Phase 3,Phase 1
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1
23 Anti-Infective Agents Phase 4,Phase 3
24 Immunosuppressive Agents Phase 4,Phase 3,Phase 1,Early Phase 1
25 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1
26 Antimetabolites Phase 4,Early Phase 1
27 Antimetabolites, Antineoplastic Phase 4,Early Phase 1
28 Chlorhexidine gluconate Phase 4
29 EMLA Phase 4
30 diuretics Phase 4
31 Natriuretic Agents Phase 4
32 Sodium Channel Blockers Phase 4
33 Cortisol succinate Phase 4
34 Tocopherols Phase 4
35 Tocotrienols Phase 4
36 Dermatologic Agents Phase 4,Phase 1
37 Trace Elements Phase 4,Phase 2
38 Diuretics, Potassium Sparing Phase 4
39 Peripheral Nervous System Agents Phase 4,Phase 3
40 Anesthetics, Local Phase 4
41 Emollients Phase 4,Phase 3
42 Hydrocortisone 17-butyrate 21-propionate Phase 4
43 Hydrocortisone acetate Phase 4
44 Hydrocortisone-17-butyrate Phase 4
45 Hylan Phase 4
46 Anti-Arrhythmia Agents Phase 4
47 Vitamins Phase 4,Phase 2
48 Protective Agents Phase 4
49 Anti-Infective Agents, Local Phase 4
50 Micronutrients Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 74)
id Name Status NCT ID Phase
1 A Randomized Clinical Study Comparing Two Closure Techniques of Excised Keloids Unknown status NCT00519493 Phase 4
2 Keloid Scarring: Treatment and Pathophysiology Unknown status NCT01295099 Phase 4
3 A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars Completed NCT00754247 Phase 4
4 Effect of Transparent, Self-drying Silicone Gel on the Treatment of Hypertrophic Abdominal Scars Completed NCT01078428 Phase 4
5 Radiesse® Injectable Dermal Filler for the Treatment of Nasolabial Folds in Persons of Color Completed NCT01012388 Phase 4
6 A Post-Market Study to Evaluate Adverse Event Incidence Rates in Patients With Skin of Color Undergoing Correction of Nasolabial Folds With Hylaform, Hylaform Plus and Captique. Completed NCT00293163 Phase 4
7 Safety Study of Cosmetic Tissue Augmentation in People of Color Completed NCT01147172 Phase 4
8 Pilot Study of a Novel 532nm KTP Laser for the Treatment of Fresh Surgical Scars Completed NCT01789346 Phase 4
9 7% Lidocaine/7% Tetracaine Cream Versus 2,5% Lidocaine / 2,5% Prilocaine Cream Completed NCT02372786 Phase 4
10 The Efficacy of Laser Assisted Hair Removal in the Treatment of Acne Keloidalis Nuchae; a Pilot Study Completed NCT01548898 Phase 4
11 Facial Lipoatrophy Correction Experience With SCULPTRA ("FACES" Study) Completed NCT00360932 Phase 4
12 Treatment of Keloidscars With Intralesional Triamcinolone and 5-fluorouracil Injections-prospective, Randomized, Controlled Trial - Pilot Study Recruiting NCT02155439 Phase 4
13 Pilot Study to Evaluate Clinical Outcomes With the Use of Biovance Following Keloid Scar Revision Surgery Not yet recruiting NCT02521402 Phase 4
14 Verapamil vs Steroid to Prevent Keloid Recurrence Terminated NCT01720056 Phase 4
15 Safety and Efficacy of Infrared Diode Laser on Improvement of Scar and Prevention of Recurrence of Excised Keloid Unknown status NCT01158196 Phase 3
16 Scars After Central Venous Catheters Unknown status NCT01113125 Phase 3
17 CICATRIX in the Treatment of Hypertrophic Scars and Keloids Scars Completed NCT00993005 Phase 3
18 Silicone Gel Versus Onion Extract Gel as Prevention for Postsurgical Scars Recruiting NCT01861119 Phase 3
19 Efficacy of Intralesional Triamcinolone and 8% Topical Pirfenidone for Treatment of Keloid Scars Not yet recruiting NCT02823236 Phase 3
20 A Study to Evaluate the Effectiveness and Safety of RXI-109 on the Outcome of Keloid Excision Surgery in Healthy Adults Completed NCT02079168 Phase 2
21 Exploratory Study of the Efficacy and Safety of Juvista 250ng When Administered Following Excision of Ear Lobe Keloids Completed NCT00836147 Phase 1, Phase 2
22 Trial of Juvista (Avotermin) Following Removal of Ear Lobe Keloid Scars Completed NCT00469235 Phase 1, Phase 2
23 A Pilot Study of Apligraf for the Treatment and Prevention of Recurrence of Excised Keloids Completed NCT00587587 Phase 1, Phase 2
24 Evaluation of the Initial Safety and Efficacy of Keloid Lesions Treated With MF-4181 Completed NCT01446770 Phase 2
25 Safety of Juvista When Administered Following Excision of Ear Lobe Keloids Completed NCT00710333 Phase 1, Phase 2
26 A Study to Evaluate the Safety and Efficacy of AZX100 Drug Product Following Excision of Keloid Scars Completed NCT00825916 Phase 2
27 A Study to Evaluate the Safety and Efficacy of Additional Doses of AZX100 Drug Product Following Excision of Keloid Scars Completed NCT00892723 Phase 2
28 Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix Completed NCT00129428 Phase 1, Phase 2
29 Therapeutic Study of Bevacizumab Injection Directly Inside the Keloid Tissue Terminated NCT01408953 Phase 2
30 Efficacy 2 Part Study of Identification of Keloid Biomarkers and Effect of QAX576 on Keloid Recurrence Terminated NCT00987545 Phase 2
31 Sorafenib for Patients With Extensive Keloids Terminated NCT01425216 Phase 2
32 Comparison of Dual-mode ER:YAG Laser in Patients With Long Keloid/Hypertrophic Scars Withdrawn NCT02546076 Phase 2
33 Fractional Photothermolysis for the Treatment of Burn Scars Unknown status NCT01005992 Phase 1
34 FS2 Safety and Tolerability Study in Healthy Volunteers Completed NCT02340325 Phase 1
35 High Fluence Light Emitting Diode-Red Light (LED-RL) in Human Skin Completed NCT02630303 Phase 1
36 Calcium Electroporation for the Treatment of Keloids Recruiting NCT01941914 Phase 1
37 Study to Evaluate Fractional Collagen Synthesis Within Keloid Scars and Identify Biomarkers of Keloid Scars Terminated NCT01978301 Phase 1
38 Prevention of Hypertrophic Scars or Keloids Unknown status NCT00849004
39 A Substantial Equivalence Study of RD04723 and Predicate Device Unknown status NCT01736969
40 Influence of a Silicone Gel (Dermatix®) on Thoracic Scar Formation After Harvesting of Autologous Rib Cartilage Unknown status NCT00565552
41 A Prospective Comparison of Robotic and Endoscopic SMG Resection Via Retroauricular Approach Unknown status NCT01726907
42 NdYag Laser for Acne Keloidalis Nuchae Unknown status NCT00757315
43 Intralesional Cryosurgery for Basal Cell Carcinoma - a Feasibility Study Unknown status NCT01633515
44 Assessing and Improving Patient Knowledge About Keloid Scars (Keloids) Completed NCT01176877
45 Case-control Study on Matrix Metalloproteinase Levels in Tissue in Patients With Keloid Scar Completed NCT01125137
46 Treatment of Keloid Scar by Autologous Platelet Rich Plasma Obtained With RgenKit-BCT Completed NCT02922972
47 Prospective Evaluation of the Use of Intralesional Cryotherapy for Treatment of Keloid and Hypertrophic Scars Completed NCT01994616
48 High Dose Rate Brachytherapy for Treatment of Keloids Completed NCT02005055
49 Intralesional Cryotherapy With a Argon Gas Based Device for the Treatment of Keloid and Hypertrophic Scars Completed NCT02063243
50 A Post Market Study Evaluating the Safety, Device Perfomance and Possible Emergent Risks of Celotres in Preventing Recurrence in Keloid Lesions Treated Adjunctive to Surgical Excision Completed NCT01706861

Search NIH Clinical Center for Keloids

Genetic Tests for Keloids

Genetic tests related to Keloids:

id Genetic test Affiliating Genes
1 Keloids 29 24

Anatomical Context for Keloids

MalaCards organs/tissues related to Keloids:

39
Skin, Endothelial, Breast, T Cells, Bone, Kidney, Lymph Node

Publications for Keloids

Articles related to Keloids:

(show top 50) (show all 944)
id Title Authors Year
1
Introduction to Special Issue on Hypertrophic Scars and Keloids. ( 28009688 )
2017
2
Knockdown of IRF3 inhibits extracellular matrix expression in keloid fibroblasts. ( 28192879 )
2017
3
Treatment of Keloids With Excision and Adjuvant Radiation: A Single Center Experience and Review of the Literature. ( 27775986 )
2017
4
TIEG1 Represses Smad7-Mediated Activation of TGF-I^1/Smad Signaling inA Keloid Pathogenesis. ( 28108300 )
2017
5
Beta adrenergic receptor blockers reduce the occurrence of keloids and hypertrophic scars after cardiac device implantation: a single-institution case-control study. ( 28092339 )
2017
6
Association of plasminogen activator inhibitor-1 and vitamin D receptor expression with the risk of keloid disease in a Chinese population. ( 28088270 )
2017
7
Identification of skin-related lncRNAs as potential biomarkers that involved in Wnt pathways in keloids. ( 28404955 )
2017
8
A novel conformal superficial high-dose-rate brachytherapy device for the treatment of nonmelanoma skin cancer and keloids. ( 27720205 )
2017
9
Transforming Growth Factor Beta Gene Signatures are Spatially Enriched in Keloid Tissue Biopsies and Ex vivo-Cultured Keloid Fibroblasts. ( 27175945 )
2017
10
Wnt/I^-Catenin Signaling Exacerbates Keloid Cell Proliferation by Regulating Telomerase. ( 27771714 )
2016
11
NEDD4 single nucleotide polymorphism rs2271289 is associated with keloids in Chinese Han population. ( 27158346 )
2016
12
A Comparison of the Effectiveness of Triamcinolone and Radiation Therapy for Ear Keloids after Surgical Excision: A Systematic Review and Meta-Analysis. ( 27219228 )
2016
13
Comparing Two Methods of Cryotherapy and Intense Pulsed Light with Triamcinolone Injection in the Treatment of Keloid and Hypertrophic Scars: A Clinical Trial. ( 27812490 )
2016
14
A distinct X-linked syndrome involving joint contractures, keloids, large optic cup-to-disc ratio, and renal stones results from a filamin A (FLNA) mutation. ( 26804200 )
2016
15
Chemokine-Like Factor 1 (CKLF-1) is Overexpressed in Keloid Patients: A Potential Indicating Factor for Keloid-Predisposed Individuals. ( 26986142 )
2016
16
Keloids, Spontaneous or After Minor Skin Injury: Importance of Not Missing Bethlem Myopathy. ( 27563703 )
2016
17
Bilateral gigantic earlobe keloids. ( 26833527 )
2016
18
MiR-181a Targets PHLPP2 to Augment AKT Signaling and Regulate Proliferation and Apoptosis in Human Keloid Fibroblasts. ( 27915346 )
2016
19
Lipid nano-bubble combined with ultrasound for anti-keloids therapy. ( 27733083 )
2016
20
Risk factors of keloids in Syrians. ( 27646558 )
2016
21
Keloids and Hypertrophic Scars: Pathophysiology, Classification, and Treatment. ( 27347634 )
2016
22
Keloids: Current Therapies in Barbados. ( 27618292 )
2016
23
Localization of MMP-9 in multinuclear giant cells in keloids after treatment with 5-fluorouracil with or without combination of cryotherapy and cryotherapy alone. ( 27634492 )
2016
24
Novel X-linked syndrome of cardiac valvulopathy, keloid scarring, and reduced joint mobility due to filamin A substitution G1576R. ( 26686323 )
2016
25
Efficacy and safety of triamcinolone acetonide alone and in combination with 5-fluorouracil for treating hypertrophic scars and keloids: a systematic review and meta-analysis. ( 27427423 )
2016
26
Top 10 Facts You Need to Know about About Keloids and Their Treatment. ( 27328472 )
2016
27
Aberrant connective tissue differentiation towards cartilage and bone underlies human keloids in African Americans. ( 27943413 )
2016
28
Assessment of the Combined Efficacy of Needling and the Use of Silicone Gel in the Treatment of C-Section and Other Surgical Hypertrophic Scars and Keloids. ( 27538108 )
2016
29
Multiple asymptomatic cutaneous pilar leiomyoma versus spontaneous eruptive keloids - a case report. ( 27151722 )
2016
30
Co-localization of LTBP-2 with FGF-2 in fibrotic human keloid and hypertrophic scar. ( 26644005 )
2016
31
Fibulin-5 regulates keloid-derived fibroblast-like cells through integrin beta-1. ( 26095157 )
2016
32
Knockdown of lncRNA-ATB suppresses autocrine secretion of TGF-I^2 by targeting ZNF217 via miR-200c in keloid fibroblasts. ( 27090737 )
2016
33
Surgical management for large chest keloids with internal mammary artery perforator flap. ( 26982790 )
2016
34
Keloids and Hypertrophic Scars Can Now Be Cured Completely: Recent Progress in Our Understanding of the Pathogenesis of Keloids and Hypertrophic Scars and the Most Promising Current Therapeutic Strategy. ( 27180789 )
2016
35
(S002) A 15-Year Review of Radiation Therapy for Keloids at Two Institutions. ( 27083671 )
2016
36
Keloids: Animal models and pathologic equivalents to study tissue fibrosis. ( 26827712 )
2016
37
5-Fluorouracil in the Treatment of Keloids and Hypertrophic Scars: A Comprehensive Review of the Literature. ( 27105629 )
2016
38
Therapeutic Efficacy of Intralesional Steroid With Carbon Dioxide Laser Versus With Cryotherapy in Treatment of Keloids: A Randomized Controlled Trial. ( 27661432 )
2016
39
Observational retrospective study evaluating the effects of oral isotretinoin in keloids and hypertrophic scars. ( 27419807 )
2016
40
The Biomechanics and Optimization of the Needle-Syringe System for Injecting Triamcinolone Acetonide into Keloids. ( 27843936 )
2016
41
Postoperative radiotherapy in the management of keloids. ( 27994646 )
2016
42
Keloids: The paradigm of skin fibrosis - Pathomechanisms and treatment. ( 26844756 )
2016
43
Neck keloids: evaluation of risk factors and recommendation for keloid staging system. ( 27830056 )
2016
44
Surgical Excision and Adjuvant Brachytherapy vs External Beam Radiation for the Effective Treatment of Keloids: 10-Year Institutional Retrospective Analysis. ( 27553611 )
2016
45
Evidences of autologous fat grafting for the treatment of keloids and hypertrophic scars. ( 28001261 )
2016
46
IL-6 Polymorphism and Susceptibility to Keloid Formation in a Japanese Population. ( 26829033 )
2016
47
Advances in scar management: prevention and management of hypertrophic scars and keloids. ( 27163611 )
2016
48
The Incidence of Hypertrophic Scarring and Keloid Formation Following Laser Tattoo Removal with a Quality-switched Nd:YAG Laser. ( 27386045 )
2016
49
Growth Differentiation Factor-9 Promotes Fibroblast Proliferation and Migration in Keloids through the Smad2/3 Pathway. ( 27855376 )
2016
50
Pulsed dye laser versus long-pulsed Nd:YAG laser in the treatment of hypertrophic scars and keloid: A comparative randomized split-scar trial. ( 26735516 )
2016

Variations for Keloids

Expression for Keloids

Search GEO for disease gene expression data for Keloids.

Pathways for Keloids

Pathways related to Keloids according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.26 CD36 MMP1 TGFB1 TGFB3 TNC
2
Show member pathways
12.82 FAS SMAD2 SMAD3 TGFB1 TGFB3
3
Show member pathways
12.73 SMAD2 SMAD3 SMAD7 TGFB1
4
Show member pathways
12.65 MMP1 TGFB1 TGFB3 TNC
5
Show member pathways
12.52 SMAD2 SMAD3 TGFB1 TGFB3
6 12.51 FAS MMP1 SMAD2 SMAD3 TGFB1 TGFB3
7
Show member pathways
12.48 SMAD2 SMAD3 TGFB1 TGFB3
8
Show member pathways
12.41 SMAD2 SMAD3 TGFB1 TGFB3
9 12.37 SMAD2 SMAD3 TGFB1 TGFB3
10 12.36 SMAD2 SMAD3 TGFB1 TGFB3
11 12.3 SMAD2 SMAD3 TGFB1 TGFB3
12
Show member pathways
12.29 SMAD2 SMAD3 TGFB1 TGFB3
13
Show member pathways
12.24 SMAD2 SMAD3 SMAD7
14
Show member pathways
12.22 SMAD2 SMAD3 SMAD7 TGFB1
15 12.2 FAS SMAD2 TGFB1
16 12.16 SMAD2 SMAD3 TGFB1 TGFB3
17
Show member pathways
12.13 SMAD2 SMAD3 TGFB1
18 12.07 MMP1 SMAD2 SMAD3 TGFB1 TGFB3
19 12.06 MMP1 SMAD2 SMAD7
20
Show member pathways
12.03 SMAD2 SMAD3 TGFB1 TGFB3
21
Show member pathways
12.02 SMAD2 SMAD3 TGFB1 TGFB3
22 11.99 FAS SMAD3 TGFB1
23 11.99 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
24 11.92 CD36 MMP1 TGFB1
25
Show member pathways
11.85 SMAD2 SMAD3 TGFB1 TGFB3
26
Show member pathways
11.82 SMAD2 SMAD3 TGFB1
27 11.82 SMAD2 SMAD3 TGFB1 TGFB3
28 11.81 MMP1 TGFB1 TGFB3
29 11.79 TGFB1 TGFB3 TNC
30 11.73 SMAD2 SMAD3 SMAD7
31
Show member pathways
11.73 SMAD2 SMAD3 TGFB1
32 11.72 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
33 11.68 CD36 TGFB1 TGFB3
34 11.67 SMAD2 SMAD3 SMAD7 TGFB1
35
Show member pathways
11.64 SMAD2 SMAD3 SMAD7 TGFB1
36 11.62 SMAD2 SMAD3 TGFB1 TGFB3
37 11.58 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
38 11.57 TGFB1 TGFB3 TNC
39 11.54 SMAD2 SMAD3 SMAD7 TGFB1
40 11.51 MMP1 SMAD3 TGFB1
41 11.49 CD36 TGFB1 TGFB3
42 11.45 MMP1 SMAD2 SMAD3
43
Show member pathways
11.41 SMAD2 SMAD3 TGFB1
44
Show member pathways
11.38 FAS TGFB1 TGFB3
45 11.31 MMP1 TNC
46 11.22 MMP1 SMAD2 SMAD3 SMAD7 TGFB1 TNC
47 11.21 SMAD2 SMAD3
48
Show member pathways
11.17 SMAD7 TGFB1 TGFB3
49 11.15 SMAD2 TGFB1 TGFB3
50 11.15 SMAD2 SMAD3 TGFB1 TGFB3

GO Terms for Keloids

Cellular components related to Keloids according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.56 CD36 FAS TGFB1 TGFB3
2 transcription factor complex GO:0005667 9.5 SMAD2 SMAD3 SMAD7
3 extracellular matrix GO:0031012 9.26 MMP1 TGFB1 TGFB3 TNC
4 SMAD protein complex GO:0071141 9.16 SMAD2 SMAD3
5 SMAD2-SMAD3 protein complex GO:0071144 8.62 SMAD2 SMAD3

Biological processes related to Keloids according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.98 SMAD2 SMAD3 TGFB1 TGFB3
2 positive regulation of gene expression GO:0010628 9.96 SMAD2 SMAD3 TGFB1 TNC
3 regulation of apoptotic process GO:0042981 9.91 FAS TGFB1 TGFB3
4 regulation of cell proliferation GO:0042127 9.91 FAS TGFB1 TNC
5 in utero embryonic development GO:0001701 9.89 SMAD2 SMAD3 TGFB3
6 negative regulation of gene expression GO:0010629 9.88 CD36 SMAD2 TGFB1
7 response to hypoxia GO:0001666 9.87 SMAD3 TGFB1 TGFB3
8 platelet degranulation GO:0002576 9.86 CD36 TGFB1 TGFB3
9 BMP signaling pathway GO:0030509 9.81 SMAD7 TGFB1 TGFB3
10 wound healing GO:0042060 9.78 SMAD3 TGFB1 TGFB3 TNC
11 cellular response to transforming growth factor beta stimulus GO:0071560 9.77 SMAD3 SMAD7 TGFB1
12 SMAD protein signal transduction GO:0060395 9.76 SMAD2 SMAD3 TGFB1 TGFB3
13 negative regulation of fat cell differentiation GO:0045599 9.74 SMAD3 TGFB1
14 response to progesterone GO:0032570 9.74 TGFB1 TGFB3
15 extrinsic apoptotic signaling pathway GO:0097191 9.74 FAS SMAD3 TGFB1
16 positive regulation of protein secretion GO:0050714 9.73 TGFB1 TGFB3
17 mesoderm formation GO:0001707 9.73 SMAD2 SMAD3
18 embryonic cranial skeleton morphogenesis GO:0048701 9.73 SMAD2 SMAD3
19 digestive tract development GO:0048565 9.73 TGFB1 TGFB3
20 gastrulation GO:0007369 9.72 SMAD2 SMAD3
21 face morphogenesis GO:0060325 9.72 TGFB1 TGFB3
22 mammary gland development GO:0030879 9.72 TGFB1 TGFB3
23 developmental growth GO:0048589 9.72 SMAD2 SMAD3
24 T cell homeostasis GO:0043029 9.72 FAS TGFB1
25 negative regulation of mitotic cell cycle GO:0045930 9.71 SMAD3 TGFB1
26 embryonic pattern specification GO:0009880 9.71 SMAD2 SMAD3
27 positive regulation of collagen biosynthetic process GO:0032967 9.71 TGFB1 TGFB3
28 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.7 SMAD7 TGFB1
29 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895 9.7 SMAD3 TGFB1
30 positive regulation of bone mineralization GO:0030501 9.7 SMAD3 TGFB1 TGFB3
31 signal transduction involved in regulation of gene expression GO:0023019 9.69 SMAD2 SMAD3
32 negative regulation of DNA replication GO:0008156 9.69 TGFB1 TGFB3
33 endoderm development GO:0007492 9.69 SMAD2 SMAD3 TGFB1
34 activin receptor signaling pathway GO:0032924 9.68 SMAD2 SMAD3
35 pathway-restricted SMAD protein phosphorylation GO:0060389 9.68 SMAD7 TGFB1
36 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.67 FAS SMAD3
37 lens fiber cell differentiation GO:0070306 9.67 SMAD3 TGFB1
38 positive regulation of SMAD protein import into nucleus GO:0060391 9.67 TGFB1 TGFB3
39 cell-cell junction organization GO:0045216 9.67 SMAD3 TGFB1 TGFB3
40 ureteric bud development GO:0001657 9.67 SMAD2 SMAD3 SMAD7 TGFB1
41 salivary gland morphogenesis GO:0007435 9.66 TGFB1 TGFB3
42 embryonic foregut morphogenesis GO:0048617 9.65 SMAD2 SMAD3
43 SMAD protein import into nucleus GO:0007184 9.65 TGFB1 TGFB3
44 response to cholesterol GO:0070723 9.65 SMAD2 TGFB1
45 primary miRNA processing GO:0031053 9.64 SMAD2 SMAD3
46 pericardium development GO:0060039 9.64 SMAD2 SMAD3
47 nodal signaling pathway GO:0038092 9.62 SMAD2 SMAD3
48 common-partner SMAD protein phosphorylation GO:0007182 9.62 SMAD2 TGFB1
49 positive regulation of epithelial to mesenchymal transition GO:0010718 9.62 SMAD2 SMAD3 TGFB1 TGFB3
50 regulation of striated muscle tissue development GO:0016202 9.61 SMAD3 TGFB1

Molecular functions related to Keloids according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.8 SMAD2 SMAD3 TGFB1 TGFB3
2 R-SMAD binding GO:0070412 9.51 SMAD2 SMAD3
3 transforming growth factor beta binding GO:0050431 9.48 CD36 TGFB3
4 enhancer binding GO:0035326 9.46 SMAD2 SMAD3
5 co-SMAD binding GO:0070410 9.43 SMAD2 SMAD3
6 I-SMAD binding GO:0070411 9.4 SMAD2 SMAD7
7 primary miRNA binding GO:0070878 9.37 SMAD2 SMAD3
8 type II transforming growth factor beta receptor binding GO:0005114 9.32 TGFB1 TGFB3
9 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 9.26 SMAD2 SMAD3
10 transforming growth factor beta receptor binding GO:0005160 9.26 SMAD2 SMAD3 TGFB1 TGFB3
11 type III transforming growth factor beta receptor binding GO:0034714 9.16 TGFB1 TGFB3
12 type I transforming growth factor beta receptor binding GO:0034713 8.92 SMAD2 SMAD7 TGFB1 TGFB3

Sources for Keloids

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....