Aliases & Classifications for Keloids

MalaCards integrated aliases for Keloids:

Name: Keloids 37 72 28
Keloid Disorder 72
Keloid 51

Summaries for Keloids

MalaCards based summary : Keloids, also known as keloid disorder, is related to hypertrophic scars and localized scleroderma. An important gene associated with Keloids is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways are Integrin Pathway and Deubiquitination. The drugs Fluorouracil and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and bone, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Keloids

Diseases related to Keloids via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 hypertrophic scars 31.5 CD36 SMAD2 SMAD3 TGFB1 TGFB3
2 localized scleroderma 28.8 DCN MMP1 SMAD3 TGFB1
3 gingival overgrowth 28.6 CD36 DCN MMP1 TGFB1
4 nephrogenic systemic fibrosis 28.2 DCN SMAD2 SMAD3 SMAD7 TGFB1
5 keloid formation 12.4
6 torticollis, keloids, cryptorchidism, and renal dysplasia 12.1
7 x-linked keloid scarring-reduced joint mobility-increased optic cup-to-disc ratio syndrome 11.9
8 premature aging syndrome, penttinen type 11.2
9 frontometaphyseal dysplasia 2 10.9
10 desmoid tumor 10.9
11 peyronie disease 10.3 SMAD3 TGFB1
12 osteochondrosis 10.2 CD36 TGFB1
13 burn scar 10.2 FAS TGFB1
14 epithelial basement membrane dystrophy 10.2 FAS TGFB1
15 lattice corneal dystrophy 10.1 FAS TGFB1
16 urinary tract obstruction 10.1 SMAD2 SMAD3 TGFB1
17 kashin-beck disease 10.1 FAS MMP1
18 recessive dystrophic epidermolysis bullosa 10.1 MMP1 TGFB1
19 pustulosis palmaris et plantaris 10.1 SMAD7 TGFB1
20 endotheliitis 10.1
21 light chain deposition disease 10.1 MMP1 TNC
22 tuberculoid leprosy 10.1 TGFB1 TGFB3
23 gingival disease 10.1 MMP1 TGFB1
24 fibromatosis, gingival, 1 10.1 CD36 MMP1 TGFB1
25 gingival fibromatosis 10.0 CD36 MMP1 TGFB1
26 chromosome 16p13.3 deletion syndrome, proximal 10.0
27 osteoarthritis 10.0 MMP1 SMAD3 TGFB1
28 chromosome 2q35 duplication syndrome 10.0
29 fibrosis of extraocular muscles, congenital, 1 10.0
30 eosinophilic granuloma 10.0 CD36 DCN
31 acute myocarditis 9.9 FAS TNC
32 blood group, i system 9.9
33 tendinopathy 9.9 DCN MMP1
34 episodic pain syndrome, familial, 1 9.9
35 burns 9.9
36 blastomycosis 9.9
37 dupuytren contracture 9.9 DCN TGFB1
38 osteofibrous dysplasia 9.9 CD36 TGFB1
39 bethlem myopathy 1 9.8
40 insulin-like growth factor i 9.8
41 multiple mitochondrial dysfunctions syndrome 5 9.8
42 scar contracture 9.8
43 leiomyoma 9.8
44 lobomycosis 9.8
45 dermatitis 9.8
46 myopathy 9.8
47 pustulosis of palm and sole 9.8
48 herpes zoster 9.8
49 psoriasis 9.8
50 ureteral disease 9.8 SMAD2 SMAD3 SMAD7 TGFB1

Graphical network of the top 20 diseases related to Keloids:



Diseases related to Keloids

Symptoms & Phenotypes for Keloids

MGI Mouse Phenotypes related to Keloids:

43 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 CD36 DCN FAS SMAD2 SMAD3 SMAD7
2 homeostasis/metabolism MP:0005376 10.22 MMP1 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
3 cellular MP:0005384 10.19 CD36 DCN FAS SMAD2 SMAD3 SMAD7
4 digestive/alimentary MP:0005381 10.17 CD36 DCN FAS SMAD2 SMAD3 SMAD7
5 immune system MP:0005387 10.16 CD36 DCN FAS MMP1 SMAD2 SMAD3
6 growth/size/body region MP:0005378 10.15 CD36 DCN FAS SMAD2 SMAD3 SMAD7
7 cardiovascular system MP:0005385 10.14 CD36 FAS SMAD2 SMAD3 SMAD7 TGFB1
8 hematopoietic system MP:0005397 10.14 CD36 DCN FAS SMAD2 SMAD3 SMAD7
9 craniofacial MP:0005382 10.12 DCN FAS SMAD2 SMAD3 SMAD7 TGFB1
10 endocrine/exocrine gland MP:0005379 10.1 SMAD2 SMAD3 SMAD7 TGFB1 CD36 DCN
11 mortality/aging MP:0010768 10.06 FAS SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
12 integument MP:0010771 9.97 SMAD2 SMAD3 SMAD7 TGFB1 DCN FAS
13 nervous system MP:0003631 9.95 CD36 FAS SMAD2 SMAD3 TGFB1 TGFB3
14 neoplasm MP:0002006 9.91 DCN FAS MMP1 SMAD2 SMAD3 TGFB1
15 liver/biliary system MP:0005370 9.88 CD36 FAS SMAD2 SMAD3 TGFB1
16 normal MP:0002873 9.85 TNC DCN FAS SMAD2 SMAD7 TGFB3
17 reproductive system MP:0005389 9.73 DCN FAS SMAD2 SMAD3 SMAD7 TGFB1
18 renal/urinary system MP:0005367 9.72 CD36 DCN FAS SMAD3 TGFB1
19 respiratory system MP:0005388 9.55 DCN FAS SMAD2 TGFB1 TGFB3
20 skeleton MP:0005390 9.5 CD36 DCN FAS SMAD2 SMAD3 TGFB1
21 vision/eye MP:0005391 9.17 SMAD2 SMAD3 TGFB1 TGFB3 CD36 DCN

Drugs & Therapeutics for Keloids

Drugs for Keloids (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 101)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 4,Phase 2 51-21-8 3385
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 1 124-94-7 31307
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4
Povidone-iodine Approved Phase 4 25655-41-8
5
Ethanol Approved Phase 4 64-17-5 702
6
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 657311 5754
7
Petrolatum Approved, Investigational Phase 4 8009-03-8
8
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
9
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
10
Prilocaine Approved Phase 4 721-50-6 4906
11
Tetracaine Approved, Vet_approved Phase 4 94-24-6 5411
12
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
13
Verapamil Approved Phase 4 52-53-9 2520
14 Tocopherol Approved, Investigational, Nutraceutical Phase 4
15
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
16
Butyric Acid Experimental, Investigational Phase 4 107-92-6 264
17 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1
18 Antimetabolites Phase 4,Phase 2
19 Antimetabolites, Antineoplastic Phase 4,Phase 2
20 glucocorticoids Phase 4,Phase 3,Phase 1
21 Hormone Antagonists Phase 4,Phase 3,Phase 1
22 Hormones Phase 4,Phase 3,Phase 1
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1
24 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
25 triamcinolone acetonide Phase 4,Phase 3,Phase 1
26 Triamcinolone diacetate Phase 4,Phase 3,Phase 1
27 Triamcinolone hexacetonide Phase 4,Phase 3,Phase 1
28 Anesthetics Phase 4
29 Anti-Infective Agents Phase 4,Phase 3
30 Antiemetics Phase 4
31 Antineoplastic Agents, Hormonal Phase 4
32 Autonomic Agents Phase 4
33 BB 1101 Phase 4
34 Dexamethasone acetate Phase 4 1177-87-3
35 Gastrointestinal Agents Phase 4
36 HIV Protease Inhibitors Phase 4
37 Peripheral Nervous System Agents Phase 4,Phase 3
38
protease inhibitors Phase 4
39 Anti-Infective Agents, Local Phase 4
40 Antioxidants Phase 4
41 Central Nervous System Depressants Phase 4
42 Cortisol succinate Phase 4
43 Hydrocortisone 17-butyrate 21-propionate Phase 4
44 Hydrocortisone acetate Phase 4
45 Hydrocortisone-17-butyrate Phase 4
46 Micronutrients Phase 4,Phase 2
47 Protective Agents Phase 4
48 Tocopherols Phase 4
49 Tocotrienols Phase 4
50 Trace Elements Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 79)

# Name Status NCT ID Phase Drugs
1 Pilot Study to Evaluate Clinical Outcomes With the Use of Biovance Following Keloid Scar Revision Surgery Unknown status NCT02521402 Phase 4
2 Keloid Scarring: Treatment and Pathophysiology Unknown status NCT01295099 Phase 4 5- fluorouracil;Triamcinolone
3 A Randomized Clinical Study Comparing Two Closure Techniques of Excised Keloids Unknown status NCT00519493 Phase 4
4 Surgical Excision and Intralesional Steroid Injection for Prevention of Post Caesarean Keloid Recurrence Completed NCT03239964 Phase 4 Dexamethasone
5 A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars Completed NCT00754247 Phase 4 0.5% hydrocortisone, silicone, vitamin E lotion;Onion extract gel;Cetearyl alcohol lotion
6 Effect of Transparent, Self-drying Silicone Gel on the Treatment of Hypertrophic Abdominal Scars Completed NCT01078428 Phase 4
7 Radiesse® Injectable Dermal Filler for the Treatment of Nasolabial Folds in Persons of Color Completed NCT01012388 Phase 4
8 A Post-Market Study to Evaluate Adverse Event Incidence Rates in Patients With Skin of Color Undergoing Correction of Nasolabial Folds With Hylaform, Hylaform Plus and Captique. Completed NCT00293163 Phase 4
9 Pilot Study of a Novel 532nm KTP Laser for the Treatment of Fresh Surgical Scars Completed NCT01789346 Phase 4
10 7% Lidocaine/7% Tetracaine Cream Versus 2,5% Lidocaine / 2,5% Prilocaine Cream Completed NCT02372786 Phase 4 2,5% lidocaine / 2,5% prilocaine cream;7% lidocaine / 7% tetracaine cream
11 The Efficacy of Laser Assisted Hair Removal in the Treatment of Acne Keloidalis Nuchae; a Pilot Study Completed NCT01548898 Phase 4
12 Facial Lipoatrophy Correction Experience With SCULPTRA ("FACES" Study) Completed NCT00360932 Phase 4
13 Treatment of Keloidscars With Intralesional Triamcinolone and 5-fluorouracil Injections-prospective, Randomized, Controlled Trial - Pilot Study Recruiting NCT02155439 Phase 4 5-fluorouracil;Triamcinolone
14 Verapamil vs Steroid to Prevent Keloid Recurrence Terminated NCT01720056 Phase 4 Verapamil;Kenalog 10
15 Safety and Efficacy of Infrared Diode Laser on Improvement of Scar and Prevention of Recurrence of Excised Keloid Unknown status NCT01158196 Phase 3
16 Scars After Central Venous Catheters Unknown status NCT01113125 Phase 3 Betamethason-17-valerate and fusidic acid;Fusidic Acid
17 CICATRIX in the Treatment of Hypertrophic Scars and Keloids Scars Completed NCT00993005 Phase 3
18 Efficacy of Intralesional Triamcinolone and 8% Topical Pirfenidone for Treatment of Keloid Scars Recruiting NCT02823236 Phase 3 Topical Pirfenidone;Triamcinolone + Pirfenidone;Intralesional Triamcinolone
19 Silicone Gel Versus Onion Extract Gel as Prevention for Postsurgical Scars Recruiting NCT01861119 Phase 3 Silicone gel Kelo-cort™;;Onion extract gel Contractubex™
20 A Study to Evaluate the Effectiveness and Safety of RXI-109 on the Outcome of Keloid Excision Surgery in Healthy Adults Completed NCT02079168 Phase 2 RXI-109;Placebo
21 Exploratory Study of the Efficacy and Safety of Juvista 250ng When Administered Following Excision of Ear Lobe Keloids Completed NCT00836147 Phase 1, Phase 2 Avotermin (Juvista);Placebo
22 Evaluation of the Initial Safety and Efficacy of Keloid Lesions Treated With MF-4181 Completed NCT01446770 Phase 2
23 A Pilot Study of Apligraf for the Treatment and Prevention of Recurrence of Excised Keloids Completed NCT00587587 Phase 1, Phase 2
24 Trial of Juvista (Avotermin) Following Removal of Ear Lobe Keloid Scars Completed NCT00469235 Phase 1, Phase 2 Avotermin
25 Safety of Juvista When Administered Following Excision of Ear Lobe Keloids Completed NCT00710333 Phase 1, Phase 2 Avotermin;placebo
26 A Study to Evaluate the Safety and Efficacy of AZX100 Drug Product Following Excision of Keloid Scars Completed NCT00825916 Phase 2 AZX100 Drug Product;AZX100 Drug Product;Placebo
27 A Study to Evaluate the Safety and Efficacy of Additional Doses of AZX100 Drug Product Following Excision of Keloid Scars Completed NCT00892723 Phase 2 AZX100 Drug Product;Placebo;AZX100 Drug Product
28 Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix Completed NCT00129428 Phase 1, Phase 2
29 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts Recruiting NCT02705352 Phase 2 5-Fluorouracil
30 Therapeutic Study of Bevacizumab Injection Directly Inside the Keloid Tissue Terminated NCT01408953 Phase 2
31 Sorafenib for Patients With Extensive Keloids Terminated NCT01425216 Phase 2 Sorafenib
32 Efficacy 2 Part Study of Identification of Keloid Biomarkers and Effect of QAX576 on Keloid Recurrence Terminated NCT00987545 Phase 2 QAX576;QAX576 placebo
33 Comparison of Dual-mode ER:YAG Laser in Patients With Long Keloid/Hypertrophic Scars Withdrawn NCT02546076 Phase 2
34 Fractional Photothermolysis for the Treatment of Burn Scars Unknown status NCT01005992 Phase 1
35 FS2 Safety and Tolerability Study in Healthy Volunteers Completed NCT02340325 Phase 1 Acute Application of kynurenic acid cream;Chronic application of kynurenic acid cream
36 High Fluence Light Emitting Diode-Red Light (LED-RL) in Human Skin Completed NCT02630303 Phase 1
37 Calcium Electroporation for the Treatment of Keloids Recruiting NCT01941914 Phase 1 Calcium chloride
38 Phase 1 Study of HF-LED-RL in Fitzpatrick Skin Types I to III Recruiting NCT03433222 Phase 1
39 Study to Evaluate Fractional Collagen Synthesis Within Keloid Scars and Identify Biomarkers of Keloid Scars Terminated NCT01978301 Phase 1 Triamcinolone acetonide;Placebo
40 Prevention of Hypertrophic Scars or Keloids Unknown status NCT00849004
41 A Substantial Equivalence Study of RD04723 and Predicate Device Unknown status NCT01736969
42 Influence of a Silicone Gel (Dermatix®) on Thoracic Scar Formation After Harvesting of Autologous Rib Cartilage Unknown status NCT00565552 Silicone gel (Dermatix®)
43 A Prospective Comparison of Robotic and Endoscopic SMG Resection Via Retroauricular Approach Unknown status NCT01726907
44 NdYag Laser for Acne Keloidalis Nuchae Unknown status NCT00757315 Topical corticosteroid alone
45 Intralesional Cryosurgery for Basal Cell Carcinoma - a Feasibility Study Unknown status NCT01633515
46 Treatment of Keloid Scar by Autologous Platelet Rich Plasma Obtained With RgenKit-BCT Completed NCT02922972
47 Assessing and Improving Patient Knowledge About Keloid Scars (Keloids) Completed NCT01176877
48 Prospective Evaluation of the Use of Intralesional Cryotherapy for Treatment of Keloid and Hypertrophic Scars Completed NCT01994616
49 Case-control Study on Matrix Metalloproteinase Levels in Tissue in Patients With Keloid Scar Completed NCT01125137
50 High Dose Rate Brachytherapy for Treatment of Keloids Completed NCT02005055

Search NIH Clinical Center for Keloids

Genetic Tests for Keloids

Genetic tests related to Keloids:

# Genetic test Affiliating Genes
1 Keloids 28

Anatomical Context for Keloids

MalaCards organs/tissues related to Keloids:

38
Skin, Endothelial, Bone, Breast, Liver, T Cells, Kidney

Publications for Keloids

Articles related to Keloids:

(show top 50) (show all 1005)
# Title Authors Year
1
The Cellular Response of Keloids and Hypertrophic Scars to Botulinum Toxin A: A Comprehensive Literature Review. ( 29401161 )
2018
2
Insights into the Pathophysiology of Hypertrophic Scars and Keloids: How Do They Differ? ( 29240593 )
2018
3
Optimizing Radiotherapy for Keloids: A Meta-Analysis Systematic Review Comparing Recurrence Rates Between Different Radiation Modalities. ( 29239971 )
2018
4
The Effects of Postoperative Intralesional Corticosteroids in the Prevention of Recurrent Earlobe Keloids: A Multispecialty Retrospective Review. ( 29381548 )
2018
5
Delayed diagnosis of dermal leiomyosarcoma mimicking keloid scar. ( 29374640 )
2018
6
Keloid formation on neck after jugular central venous catheter placement: An unsightly unusual complication in a young female. ( 29416158 )
2018
7
Tumor suppressive role of miR-1224-5p in keloid proliferation, apoptosis and invasion via the TGF-I^1/Smad3 signaling pathway. ( 29050938 )
2018
8
Three-dimensional poly lactic-co-glycolic acid scaffold containing autologous platelet-rich plasma supports keloid fibroblast growth and contributes to keloid formation in a nude mouse model. ( 29122407 )
2018
9
Efficacy and the toxicity of the interstitial high-dose-rate brachytherapy in the management of recurrent keloids: 5-year outcomes. ( 29305151 )
2018
10
Complete excision of proliferating core in auricular keloids significantly reduces local recurrence: A prospective study. ( 29083048 )
2018
11
A Rare Case of Misdiagnosis: Recurrence of Dermatofibrosarcoma Protuberans That Was Treated Surgicallyas a Keloid. ( 29416224 )
2018
12
Optimizing Radiotherapy for Keloids. ( 29319568 )
2018
13
Commentary on The Cellular Response of Keloids and Hypertrophic Scars to Botulinum Toxin A: A Comprehensive Literature Review. ( 29309344 )
2018
14
Insights into the Pathophysiology of Hypertrophic Scars and Keloids: How Do They Differ? ( 29240586 )
2018
15
Pediatric dermatology procedures and pearls: Multimodal revision of earlobe keloids. ( 29266377 )
2017
16
Histological analysis of hyalinised keloidal collagen formation in earlobe keloids over time: collagen hyalinisation starts in the perivascular area. ( 28467018 )
2017
17
Measurement of Pressure in Compressive Magnet Therapy for Auricular Keloids. ( 28607859 )
2017
18
TIEG1 Represses Smad7-Mediated Activation of TGF-I^1/Smad Signaling inA Keloid Pathogenesis. ( 28108300 )
2017
19
S-shaped Wound Closure Technique for Dumbbell-shaped Keloids. ( 28458983 )
2017
20
Gene expression profiling analysis of keloids with and without hydrocortisone treatment. ( 29285054 )
2017
21
Identification of ASAH1 as a susceptibility gene for familial keloids. ( 28905881 )
2017
22
A Role for Neuregulin-1 in Promoting Keloid Fibroblast Migration via ErbB2-mediated Signaling. ( 27882385 )
2017
23
Beta adrenergic receptor blockers reduce the occurrence of keloids and hypertrophic scars after cardiac device implantation: a single-institution case-control study. ( 28092339 )
2017
24
A case-control study analyzing the association of keloids with hypertension and obesity. ( 28497468 )
2017
25
Expansion of CD26 positive fibroblast population promotes keloid progression. ( 28454879 )
2017
26
Treatment of ear keloids: algorithm for a multimodal therapy regimen. ( 28825129 )
2017
27
miR-21 promotes collagen production in keloid via Smad7. ( 27717618 )
2017
28
miR-141-3p inhibits fibroblast proliferation and migration by targeting GAB1 in keloids. ( 28619509 )
2017
29
Upregulation of microRNA-205 suppresses vascular endothelial growth factor expression-mediated PI3K/Akt signaling transduction in human keloid fibroblasts. ( 27651436 )
2017
30
Techniques for Optimizing Surgical Scars, Part 2: Hypertrophic Scars and Keloids. ( 29282183 )
2017
31
Asiaticoside hinders the invasive growth of keloid fibroblasts through inhibition of the GDF-9/MAPK/Smad pathway. ( 28346732 )
2017
32
Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis. ( 28287424 )
2017
33
Autografting in the treatment of large, auricular keloids. ( 29288488 )
2017
34
Association of plasminogen activator inhibitor-1 and vitamin D receptor expression with the risk of keloid disease in a Chinese population. ( 28088270 )
2017
35
Relationship between Keloid Formation and YAP/TAZ Signaling. ( 28740772 )
2017
36
A Case of Keloids Complicated by Castleman's Disease: Interleukin-6 as a Keloid Risk Factor. ( 28607862 )
2017
37
Morphological and morphometric analysis of the effects of intralesional tamoxifen on keloids. ( 28440733 )
2017
38
Downregulation of I^-catenin blocks fibrosis via Wnt2 signaling in human keloid fibroblasts. ( 28656880 )
2017
39
Giant bilateral keloids of the ear lobule: Case report and brief review of literature. ( 29417034 )
2017
40
Corneal Myofibroma (Keloid) in a Young Patient with Neurofibromatosis Type 2. ( 29344474 )
2017
41
Reconstitution of Human Keloids in Mouse Skin. ( 28507865 )
2017
42
Topical cryoanesthesia for the relief of pain caused by steroid injections used to treat hypertrophic scars and keloids. ( 29069016 )
2017
43
Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population. ( 28437551 )
2017
44
Review of Silicone Gel Sheeting and Silicone Gel for the Prevention of Hypertrophic Scars and Keloids. ( 28570253 )
2017
45
Bilateral breast keloids in an elderly woman associated with bilateral breast cancers and high concentration of serum tumor growth factor-I^. ( 29098727 )
2017
46
Transforming Growth Factor Beta Gene Signatures are Spatially Enriched in Keloid Tissue Biopsies and Ex vivo-Cultured Keloid Fibroblasts. ( 27175945 )
2017
47
Comparison of Intralesional Triamcinolone Acetonide, 5-Fluorouracil, and Their Combination for the Treatment of Keloids. ( 29098115 )
2017
48
Fractional Carbon Dioxide, Long Pulse Nd:YAG and Pulsed Dye Laser in the Management of Keloids. ( 28852292 )
2017
49
A novel conformal superficial high-dose-rate brachytherapy device for the treatment of nonmelanoma skin cancer and keloids. ( 27720205 )
2017
50
Introduction to Special Issue on Hypertrophic Scars and Keloids. ( 28009688 )
2017

Variations for Keloids

Expression for Keloids

Search GEO for disease gene expression data for Keloids.

Pathways for Keloids

Pathways related to Keloids according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.24 CD36 MMP1 TGFB1 TGFB3 TNC
2
Show member pathways
12.74 SMAD2 SMAD3 SMAD7 TGFB1
3 12.72 FAS MMP1 SMAD2 SMAD3 TGFB1 TGFB3
4
Show member pathways
12.68 SMAD2 SMAD3 TGFB1 TGFB3
5
Show member pathways
12.67 DCN MMP1 TGFB1 TGFB3 TNC
6
Show member pathways
12.53 SMAD2 SMAD3 TGFB1 TGFB3
7
Show member pathways
12.51 MMP1 SMAD2 SMAD3 TGFB1
8
Show member pathways
12.5 FAS SMAD3 TGFB1 TGFB3
9
Show member pathways
12.45 FAS SMAD2 SMAD3 TGFB1 TGFB3
10
Show member pathways
12.41 SMAD2 SMAD3 TGFB1 TGFB3
11 12.37 SMAD2 SMAD3 TGFB1 TGFB3
12 12.32 SMAD2 SMAD3 TGFB1 TGFB3
13 12.26 DCN FAS SMAD2 TGFB1
14
Show member pathways
12.25 SMAD2 SMAD3 SMAD7
15
Show member pathways
12.24 SMAD2 SMAD3 SMAD7 TGFB1
16 12.19 SMAD2 SMAD3 TGFB1 TGFB3
17
Show member pathways
12.14 SMAD2 SMAD3 TGFB1
18 12.12 SMAD2 SMAD3 TGFB1 TGFB3
19 12.08 MMP1 SMAD2 SMAD7
20
Show member pathways
12.08 SMAD2 SMAD3 TGFB1 TGFB3
21 12.05 MMP1 SMAD2 SMAD3 TGFB1 TGFB3
22
Show member pathways
12.03 SMAD2 SMAD3 TGFB1 TGFB3
23 12.01 SMAD2 SMAD3 TGFB1 TGFB3
24 12 FAS SMAD3 TGFB1
25 11.99 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
26 11.93 CD36 MMP1 TGFB1
27 11.85 DCN TGFB1 TGFB3
28 11.84 SMAD2 SMAD3 TGFB1 TGFB3
29
Show member pathways
11.83 SMAD2 SMAD3 TGFB1
30 11.81 MMP1 TGFB1 TGFB3
31 11.8 TGFB1 TGFB3 TNC
32
Show member pathways
11.8 SMAD2 SMAD3 TGFB1 TGFB3
33
Show member pathways
11.74 SMAD2 SMAD3 TGFB1
34 11.73 SMAD2 SMAD3 SMAD7
35 11.7 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
36 11.67 SMAD2 SMAD3 SMAD7 TGFB1
37 11.65 CD36 TGFB1 TGFB3
38
Show member pathways
11.64 SMAD2 SMAD3 SMAD7 TGFB1
39
Show member pathways
11.56 SMAD2 SMAD3 TGFB1 TGFB3
40 11.56 MMP1 SMAD2 SMAD3 SMAD7 TGFB1 TNC
41 11.54 SMAD2 SMAD3 SMAD7 TGFB1
42 11.53 MMP1 SMAD3 TGFB1
43 11.51 CD36 TGFB1 TGFB3
44 11.51 DCN TGFB1 TGFB3 TNC
45 11.47 MMP1 SMAD2 SMAD3
46
Show member pathways
11.34 FAS TGFB1 TGFB3
47 11.32 MMP1 TNC
48 11.26 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
49 11.25 DCN MMP1
50 11.21 SMAD2 SMAD3

GO Terms for Keloids

Cellular components related to Keloids according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.67 CD36 FAS TGFB1 TGFB3
2 proteinaceous extracellular matrix GO:0005578 9.56 DCN MMP1 TGFB1 TNC
3 transcription factor complex GO:0005667 9.5 SMAD2 SMAD3 SMAD7
4 SMAD protein complex GO:0071141 9.16 SMAD2 SMAD3
5 extracellular matrix GO:0031012 9.02 DCN MMP1 TGFB1 TGFB3 TNC
6 heteromeric SMAD protein complex GO:0071144 8.96 SMAD2 SMAD3

Biological processes related to Keloids according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.99 SMAD2 SMAD3 TGFB1 TGFB3
2 positive regulation of gene expression GO:0010628 9.93 CD36 SMAD2 SMAD3 TGFB1 TNC
3 regulation of cell proliferation GO:0042127 9.91 FAS TGFB1 TNC
4 negative regulation of gene expression GO:0010629 9.9 CD36 SMAD2 TGFB1
5 in utero embryonic development GO:0001701 9.88 SMAD2 SMAD3 TGFB3
6 aging GO:0007568 9.87 DCN TGFB1 TGFB3
7 response to hypoxia GO:0001666 9.87 SMAD3 TGFB1 TGFB3
8 platelet degranulation GO:0002576 9.85 CD36 TGFB1 TGFB3
9 BMP signaling pathway GO:0030509 9.82 SMAD7 TGFB1 TGFB3
10 cellular response to transforming growth factor beta stimulus GO:0071560 9.79 SMAD3 SMAD7 TGFB1
11 SMAD protein signal transduction GO:0060395 9.78 SMAD2 SMAD3 TGFB1 TGFB3
12 extrinsic apoptotic signaling pathway GO:0097191 9.76 FAS SMAD3 TGFB1
13 positive regulation of bone mineralization GO:0030501 9.75 SMAD3 TGFB1 TGFB3
14 embryonic cranial skeleton morphogenesis GO:0048701 9.73 SMAD2 SMAD3
15 gastrulation GO:0007369 9.73 SMAD2 SMAD3
16 mesoderm formation GO:0001707 9.73 SMAD2 SMAD3
17 digestive tract development GO:0048565 9.72 TGFB1 TGFB3
18 mammary gland development GO:0030879 9.72 TGFB1 TGFB3
19 negative regulation of mitotic cell cycle GO:0045930 9.72 SMAD3 TGFB1
20 face morphogenesis GO:0060325 9.71 TGFB1 TGFB3
21 developmental growth GO:0048589 9.71 SMAD2 SMAD3
22 cell growth GO:0016049 9.71 TGFB1 TGFB3
23 embryonic pattern specification GO:0009880 9.71 SMAD2 SMAD3
24 positive regulation of epithelial to mesenchymal transition GO:0010718 9.71 SMAD2 SMAD3 TGFB1 TGFB3
25 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.7 SMAD7 TGFB1
26 positive regulation of collagen biosynthetic process GO:0032967 9.7 TGFB1 TGFB3
27 endoderm development GO:0007492 9.7 SMAD2 SMAD3 TGFB1
28 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.69 SMAD3 TGFB1
29 signal transduction involved in regulation of gene expression GO:0023019 9.69 SMAD2 SMAD3
30 negative regulation of DNA replication GO:0008156 9.69 TGFB1 TGFB3
31 cell-cell junction organization GO:0045216 9.69 SMAD3 TGFB1 TGFB3
32 activin receptor signaling pathway GO:0032924 9.68 SMAD2 SMAD3
33 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.68 FAS SMAD3
34 lens fiber cell differentiation GO:0070306 9.67 SMAD3 TGFB1
35 pathway-restricted SMAD protein phosphorylation GO:0060389 9.67 SMAD7 TGFB1
36 response to cholesterol GO:0070723 9.67 SMAD2 TGFB1
37 positive regulation of SMAD protein import into nucleus GO:0060391 9.67 SMAD3 TGFB1 TGFB3
38 ureteric bud development GO:0001657 9.67 SMAD2 SMAD3 SMAD7 TGFB1
39 salivary gland morphogenesis GO:0007435 9.66 TGFB1 TGFB3
40 primary miRNA processing GO:0031053 9.65 SMAD2 SMAD3
41 embryonic foregut morphogenesis GO:0048617 9.65 SMAD2 SMAD3
42 pericardium development GO:0060039 9.65 SMAD2 SMAD3
43 transforming growth factor beta receptor signaling pathway GO:0007179 9.65 SMAD2 SMAD3 SMAD7 TGFB1 TGFB3
44 nodal signaling pathway GO:0038092 9.64 SMAD2 SMAD3
45 common-partner SMAD protein phosphorylation GO:0007182 9.63 SMAD2 TGFB1
46 regulation of striated muscle tissue development GO:0016202 9.63 SMAD3 TGFB1
47 SMAD protein complex assembly GO:0007183 9.63 SMAD2 SMAD3 TGFB1
48 negative regulation of macrophage cytokine production GO:0010936 9.62 TGFB1 TGFB3
49 positive regulation of extracellular matrix assembly GO:1901203 9.61 SMAD3 TGFB1
50 response to laminar fluid shear stress GO:0034616 9.61 SMAD7 TGFB1 TGFB3

Molecular functions related to Keloids according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.83 SMAD2 SMAD3 TGFB1 TGFB3
2 R-SMAD binding GO:0070412 9.51 SMAD2 SMAD3
3 collagen binding GO:0005518 9.5 DCN SMAD3 SMAD7
4 transforming growth factor beta binding GO:0050431 9.49 CD36 TGFB3
5 enhancer binding GO:0035326 9.48 SMAD2 SMAD3
6 co-SMAD binding GO:0070410 9.46 SMAD2 SMAD3
7 I-SMAD binding GO:0070411 9.43 SMAD2 SMAD7
8 primary miRNA binding GO:0070878 9.4 SMAD2 SMAD3
9 type II transforming growth factor beta receptor binding GO:0005114 9.37 TGFB1 TGFB3
10 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 9.26 SMAD2 SMAD3
11 transforming growth factor beta receptor binding GO:0005160 9.26 SMAD2 SMAD3 TGFB1 TGFB3
12 type III transforming growth factor beta receptor binding GO:0034714 9.16 TGFB1 TGFB3
13 type I transforming growth factor beta receptor binding GO:0034713 8.92 SMAD2 SMAD7 TGFB1 TGFB3

Sources for Keloids

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
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67 TGDB
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70 UMLS via Orphanet
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