MCID: KRT003
MIFTS: 33

Keratinizing Squamous Cell Carcinoma malady

Cancer diseases, Skin diseases categories
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Summaries for Keratinizing Squamous Cell Carcinoma

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Disease Ontology:8 A squamous cell carcinoma that presents as single, isolated cells with bizzare cytoplasmic shapes, intense cytoplasmic eosinophilia, and intensely hyperchromatic, angular nuclei in a background of necrotic and keratinous debris.

MalaCards based summary: Keratinizing Squamous Cell Carcinoma, also known as squamous cell carcinoma, keratinizing, is related to adenocarcinoma and vulvar keratinizing squamous cell carcinoma. An important gene associated with Keratinizing Squamous Cell Carcinoma is KRT8 (keratin 8). The compounds mitoxantrone and adriamycin have been mentioned in the context of this disorder. Affiliated tissues include cervix, kidney and liver, and related mouse phenotype digestive/alimentary.

Aliases & Classifications for Keratinizing Squamous Cell Carcinoma

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Keratinizing Squamous Cell Carcinoma, Aliases & Descriptions:

Name: Keratinizing Squamous Cell Carcinoma 8
Squamous Cell Carcinoma, Keratinizing 8 62
 
Keratinizing Epidermoid Carcinoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:5521
SNOMED-CT57 189568009, 18048008
NCIt39 C4105

Related Diseases for Keratinizing Squamous Cell Carcinoma

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Graphical network of the top 20 diseases related to Keratinizing Squamous Cell Carcinoma:



Diseases related to keratinizing squamous cell carcinoma

Symptoms for Keratinizing Squamous Cell Carcinoma

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Drugs & Therapeutics for Keratinizing Squamous Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Keratinizing Squamous Cell Carcinoma

Search NIH Clinical Center for Keratinizing Squamous Cell Carcinoma

Genetic Tests for Keratinizing Squamous Cell Carcinoma

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Anatomical Context for Keratinizing Squamous Cell Carcinoma

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MalaCards organs/tissues related to Keratinizing Squamous Cell Carcinoma:

32
Cervix, Kidney, Liver, Skin

Animal Models for Keratinizing Squamous Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Keratinizing Squamous Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.1KRT8, BCL2

Publications for Keratinizing Squamous Cell Carcinoma

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Articles related to Keratinizing Squamous Cell Carcinoma:

(show all 14)
idTitleAuthorsYear
1
Sinonasal non-keratinizing squamous cell carcinoma with nasal skin extension as the initial presentation. (22775560)
2012
2
Mammary invasive ductal adenocarcinoma and vulvar invasive keratinizing squamous cell carcinoma in a woman with disseminated discoid lupus erythematosus (DDLE) - a case review. (21876498)
2011
3
Rare coexistence of keratinizing squamous cell carcinoma with xanthogranulomatous pyelonephritis in the same kidney: report of two cases. (21119270)
2010
4
Psammoma bodies in cervical smear in association with keratinizing squamous cell carcinoma of cervix: a case report. (19217043)
2009
5
Epidemiology of nasopharyngeal carcinoma in the United States: improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology. (17060483)
2007
6
Keratinizing squamous cell carcinoma of the cervix in a sexually inexperienced woman: a case report. (17039710)
2006
7
Differential expression of anti-apoptotic protein Bcl-2 in keratinizing versus non-keratinizing squamous cell carcinoma of the anus. (15688099)
2005
8
Vulvar keratinizing squamous cell carcinoma in a 26-year-old woman. (11175649)
2001
9
Primary keratinizing squamous cell carcinoma: an exceptional tumor of the gallbladder. (19864815)
1997
10
Case report: primary cystic keratinizing squamous cell carcinoma of the liver in a patient with treated nasopharyngeal carcinoma. (9142640)
1997
11
Basaloid carcinoma and keratinizing squamous cell carcinoma of the vulva: a case of two primary carcinomas. (8572644)
1995
12
Neoplastic cell spreading in rodent transplantable tumor models. II. Santamaria tumor (syngeneic keratinizing squamous cell carcinoma). (2378738)
1990
13
Glandular cell properties of cell line (HKUS) derived from small cell non-keratinizing squamous cell carcinoma of the uterine cervix. (2838556)
1988
14
An adenoid squamous carcinoma-forming cell line established from an oral keratinizing squamous cell carcinoma expressing carcinoembryonic antigen. (2429552)
1986

Variations for Keratinizing Squamous Cell Carcinoma

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Expression for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Expression patterns in normal tissues for genes affiliated with Keratinizing Squamous Cell Carcinoma

Search GEO for disease gene expression data for Keratinizing Squamous Cell Carcinoma.

Pathways for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Compounds for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Compounds related to Keratinizing Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1mitoxantrone44 50 1111.5BCL2, KRT8
2adriamycin449.5BCL2, KRT8
3okadaic acid44 6110.4BCL2, KRT8
4retinoid449.4BCL2, KRT8
5etoposide44 50 61 1112.4KRT8, BCL2
6butyrate449.4KRT8, BCL2
7tamoxifen44 50 28 1112.4KRT8, BCL2
8paclitaxel44 50 1111.4BCL2, KRT8
9doxorubicin44 50 1111.4BCL2, KRT8
10actinomycin d449.4KRT8, BCL2
11paraffin449.3BCL2, KRT8
12genistein44 28 61 2 24 1114.3KRT8, BCL2
13cisplatin44 50 61 1112.3KRT8, BCL2
14cycloheximide449.2BCL2, KRT8
15progesterone44 28 61 24 1113.2BCL2, KRT8
16oligonucleotide449.1BCL2, KRT8
17retinoic acid44 2410.1KRT8, BCL2
18vegf449.0BCL2, KRT8
19estrogen448.8BCL2, KRT8

GO Terms for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Products for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Sources for Keratinizing Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet