MCID: KRT003
MIFTS: 32

Keratinizing Squamous Cell Carcinoma malady

Cancer diseases, Skin diseases categories
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Summaries for Keratinizing Squamous Cell Carcinoma

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 A squamous cell carcinoma that presents as single, isolated cells with bizzare cytoplasmic shapes, intense cytoplasmic eosinophilia, and intensely hyperchromatic, angular nuclei in a background of necrotic and keratinous debris.

MalaCards: Keratinizing Squamous Cell Carcinoma, also known as squamous cell carcinoma, keratinizing, is related to adenocarcinoma and vulvar keratinizing squamous cell carcinoma. An important gene associated with Keratinizing Squamous Cell Carcinoma is KRT8 (keratin 8). The compounds mitoxantrone and adriamycin have been mentioned in the context of this disorder. Affiliated tissues include cervix, skin and liver, and related mouse phenotype digestive/alimentary.

Aliases & Classifications for Keratinizing Squamous Cell Carcinoma

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8Disease Ontology, 62UMLS, 40NCIt, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

keratinizing squamous cell carcinoma 8
squamous cell carcinoma, keratinizing 8 62
keratinizing epidermoid carcinoma 8


External Ids:

Disease Ontology8 DOID:5521
SNOMED-CT58 189568009, 18048008
NCIt40 C4105

Related Diseases for Keratinizing Squamous Cell Carcinoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Keratinizing Squamous Cell Carcinoma:



Diseases related to keratinizing squamous cell carcinoma

Symptoms for Keratinizing Squamous Cell Carcinoma

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Drugs & Therapeutics for Keratinizing Squamous Cell Carcinoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Keratinizing Squamous Cell Carcinoma

Search NIH Clinical Center for Keratinizing Squamous Cell Carcinoma

Genetic Tests for Keratinizing Squamous Cell Carcinoma

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Anatomical Context for Keratinizing Squamous Cell Carcinoma

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33MalaCards
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MalaCards organs/tissues related to Keratinizing Squamous Cell Carcinoma:

33
Cervix, Skin, Liver

Animal Models for Keratinizing Squamous Cell Carcinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Keratinizing Squamous Cell Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.1KRT8, BCL2

Publications for Keratinizing Squamous Cell Carcinoma

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52PubMed
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Articles related to Keratinizing Squamous Cell Carcinoma:

(show all 13)
idTitleAuthorsYear
1
Sinonasal non-keratinizing squamous cell carcinoma with nasal skin extension as the initial presentation. (22775560)
2012
2
Mammary invasive ductal adenocarcinoma and vulvar invasive keratinizing squamous cell carcinoma in a woman with disseminated discoid lupus erythematosus (DDLE) - a case review. (21876498)
2011
3
Psammoma bodies in cervical smear in association with keratinizing squamous cell carcinoma of cervix: a case report. (19217043)
2009
4
Epidemiology of nasopharyngeal carcinoma in the United States: improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology. (17060483)
2007
5
Keratinizing squamous cell carcinoma of the cervix in a sexually inexperienced woman: a case report. (17039710)
2006
6
Differential expression of anti-apoptotic protein Bcl-2 in keratinizing versus non-keratinizing squamous cell carcinoma of the anus. (15688099)
2005
7
Vulvar keratinizing squamous cell carcinoma in a 26-year-old woman. (11175649)
2001
8
Primary keratinizing squamous cell carcinoma: an exceptional tumor of the gallbladder. (19864815)
1997
9
Case report: primary cystic keratinizing squamous cell carcinoma of the liver in a patient with treated nasopharyngeal carcinoma. (9142640)
1997
10
Basaloid carcinoma and keratinizing squamous cell carcinoma of the vulva: a case of two primary carcinomas. (8572644)
1995
11
Neoplastic cell spreading in rodent transplantable tumor models. II. Santamaria tumor (syngeneic keratinizing squamous cell carcinoma). (2378738)
1990
12
Glandular cell properties of cell line (HKUS) derived from small cell non-keratinizing squamous cell carcinoma of the uterine cervix. (2838556)
1988
13
An adenoid squamous carcinoma-forming cell line established from an oral keratinizing squamous cell carcinoma expressing carcinoembryonic antigen. (2429552)
1986

Variations for Keratinizing Squamous Cell Carcinoma

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Expression for genes affiliated with Keratinizing Squamous Cell Carcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratinizing Squamous Cell Carcinoma

Search GEO for disease gene expression data for Keratinizing Squamous Cell Carcinoma.

Pathways for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Compounds for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 3BitterDB, 24HMDB
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Compounds related to Keratinizing Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1mitoxantrone45 51 1111.5KRT8, BCL2
2adriamycin459.5KRT8, BCL2
3okadaic acid45 6110.4KRT8, BCL2
4retinoid459.4KRT8, BCL2
5etoposide45 51 61 1112.4BCL2, KRT8
6butyrate459.4KRT8, BCL2
7tamoxifen45 51 29 1112.4KRT8, BCL2
8paclitaxel45 51 1111.4BCL2, KRT8
9doxorubicin45 51 1111.4KRT8, BCL2
10actinomycin d459.4BCL2, KRT8
11paraffin459.3KRT8, BCL2
12genistein45 29 61 3 24 1114.3KRT8, BCL2
13cisplatin45 51 61 1112.3BCL2, KRT8
14cycloheximide459.2KRT8, BCL2
15progesterone45 29 61 24 1113.2BCL2, KRT8
16oligonucleotide459.1KRT8, BCL2
17retinoic acid45 2410.1KRT8, BCL2
18vegf459.0KRT8, BCL2
19estrogen458.8KRT8, BCL2

GO Terms for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Products for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Sources for Keratinizing Squamous Cell Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet