MCID: KRT003
MIFTS: 27

Keratinizing Squamous Cell Carcinoma malady

Skin diseases, Cancer diseases categories

Summaries for Keratinizing Squamous Cell Carcinoma

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Disease Ontology:9 A squamous cell carcinoma that presents as single, isolated cells with bizzare cytoplasmic shapes, intense cytoplasmic eosinophilia, and intensely hyperchromatic, angular nuclei in a background of necrotic and keratinous debris.

MalaCards based summary: Keratinizing Squamous Cell Carcinoma, also known as squamous cell carcinoma, keratinizing, is related to adenoma and adenocarcinoma. An important gene associated with Keratinizing Squamous Cell Carcinoma is KRT8 (keratin 8). The compounds mitoxantrone and adriamycin have been mentioned in the context of this disorder. Affiliated tissues include cervix, kidney and liver, and related mouse phenotype digestive/alimentary.

Aliases & Classifications for Keratinizing Squamous Cell Carcinoma

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Keratinizing Squamous Cell Carcinoma, Aliases & Descriptions:

Name: Keratinizing Squamous Cell Carcinoma 9
Squamous Cell Carcinoma, Keratinizing 9 60
 
Keratinizing Epidermoid Carcinoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology9 DOID:5521
SNOMED-CT55 18048008, 189568009
NCIt38 C4105

Related Diseases for Keratinizing Squamous Cell Carcinoma

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Graphical network of the top 20 diseases related to Keratinizing Squamous Cell Carcinoma:



Diseases related to keratinizing squamous cell carcinoma

Symptoms for Keratinizing Squamous Cell Carcinoma

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Drugs & Therapeutics for Keratinizing Squamous Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Keratinizing Squamous Cell Carcinoma

Search NIH Clinical Center for Keratinizing Squamous Cell Carcinoma

Genetic Tests for Keratinizing Squamous Cell Carcinoma

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Anatomical Context for Keratinizing Squamous Cell Carcinoma

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MalaCards organs/tissues related to Keratinizing Squamous Cell Carcinoma:

31
Cervix, Kidney, Liver, Skin

Animal Models for Keratinizing Squamous Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Keratinizing Squamous Cell Carcinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.1KRT8, BCL2

Publications for Keratinizing Squamous Cell Carcinoma

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Articles related to Keratinizing Squamous Cell Carcinoma:

(show all 15)
idTitleAuthorsYear
1
Carcinoma ex-pleomorphic adenoma of the parotid gland consisting of high-grade salivary duct carcinoma and keratinizing squamous cell carcinoma. (25782724)
2015
2
Sinonasal non-keratinizing squamous cell carcinoma with nasal skin extension as the initial presentation. (22775560)
2012
3
Mammary invasive ductal adenocarcinoma and vulvar invasive keratinizing squamous cell carcinoma in a woman with disseminated discoid lupus erythematosus (DDLE) - a case review. (21876498)
2011
4
Rare coexistence of keratinizing squamous cell carcinoma with xanthogranulomatous pyelonephritis in the same kidney: report of two cases. (21119270)
2010
5
Psammoma bodies in cervical smear in association with keratinizing squamous cell carcinoma of cervix: a case report. (19217043)
2009
6
Epidemiology of nasopharyngeal carcinoma in the United States: improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology. (17060483)
2007
7
Keratinizing squamous cell carcinoma of the cervix in a sexually inexperienced woman: a case report. (17039710)
2006
8
Differential expression of anti-apoptotic protein Bcl-2 in keratinizing versus non-keratinizing squamous cell carcinoma of the anus. (15688099)
2005
9
Vulvar keratinizing squamous cell carcinoma in a 26-year-old woman. (11175649)
2001
10
Primary keratinizing squamous cell carcinoma: an exceptional tumor of the gallbladder. (19864815)
1997
11
Case report: primary cystic keratinizing squamous cell carcinoma of the liver in a patient with treated nasopharyngeal carcinoma. (9142640)
1997
12
Basaloid carcinoma and keratinizing squamous cell carcinoma of the vulva: a case of two primary carcinomas. (8572644)
1995
13
Neoplastic cell spreading in rodent transplantable tumor models. II. Santamaria tumor (syngeneic keratinizing squamous cell carcinoma). (2378738)
1990
14
Glandular cell properties of cell line (HKUS) derived from small cell non-keratinizing squamous cell carcinoma of the uterine cervix. (2838556)
1988
15
An adenoid squamous carcinoma-forming cell line established from an oral keratinizing squamous cell carcinoma expressing carcinoembryonic antigen. (2429552)
1986

Variations for Keratinizing Squamous Cell Carcinoma

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Expression for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Search GEO for disease gene expression data for Keratinizing Squamous Cell Carcinoma.

Pathways for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Compounds for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Compounds related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 19)
idCompoundScoreTop Affiliating Genes
1mitoxantrone43 49 1211.5BCL2, KRT8
2adriamycin439.5BCL2, KRT8
3okadaic acid43 5910.4BCL2, KRT8
4retinoid439.4BCL2, KRT8
5etoposide43 49 59 1212.4KRT8, BCL2
6butyrate439.4KRT8, BCL2
7tamoxifen43 49 28 1212.4KRT8, BCL2
8paclitaxel43 49 1211.4BCL2, KRT8
9doxorubicin43 49 1211.4BCL2, KRT8
10actinomycin d439.4KRT8, BCL2
11paraffin439.3BCL2, KRT8
12genistein43 28 59 2 24 1214.3KRT8, BCL2
13cisplatin43 49 59 1212.3KRT8, BCL2
14cycloheximide439.2BCL2, KRT8
15progesterone43 28 59 24 1213.2BCL2, KRT8
16oligonucleotide439.1BCL2, KRT8
17retinoic acid43 2410.1KRT8, BCL2
18vegf439.0BCL2, KRT8
19estrogen438.8BCL2, KRT8

GO Terms for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Products for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Sources for Keratinizing Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet