MCID: KRT003
MIFTS: 32

Keratinizing Squamous Cell Carcinoma malady

Cancer diseases, Skin diseases categories

Summaries for Keratinizing Squamous Cell Carcinoma

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Disease Ontology:9 A squamous cell carcinoma that presents as single, isolated cells with bizzare cytoplasmic shapes, intense cytoplasmic eosinophilia, and intensely hyperchromatic, angular nuclei in a background of necrotic and keratinous debris.

MalaCards based summary: Keratinizing Squamous Cell Carcinoma, also known as squamous cell carcinoma, keratinizing, is related to adenocarcinoma and vulvar keratinizing squamous cell carcinoma. An important gene associated with Keratinizing Squamous Cell Carcinoma is KRT8 (keratin 8). The compounds mitoxantrone and adriamycin have been mentioned in the context of this disorder. Affiliated tissues include cervix, kidney and liver, and related mouse phenotype digestive/alimentary.

Aliases & Classifications for Keratinizing Squamous Cell Carcinoma

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Keratinizing Squamous Cell Carcinoma, Aliases & Descriptions:

Name: Keratinizing Squamous Cell Carcinoma 9
Squamous Cell Carcinoma, Keratinizing 9 61
 
Keratinizing Epidermoid Carcinoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology9 DOID:5521
SNOMED-CT56 189568009, 18048008
NCIt39 C4105

Related Diseases for Keratinizing Squamous Cell Carcinoma

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Graphical network of the top 20 diseases related to Keratinizing Squamous Cell Carcinoma:



Diseases related to keratinizing squamous cell carcinoma

Symptoms for Keratinizing Squamous Cell Carcinoma

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Drugs & Therapeutics for Keratinizing Squamous Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Keratinizing Squamous Cell Carcinoma

Search NIH Clinical Center for Keratinizing Squamous Cell Carcinoma

Genetic Tests for Keratinizing Squamous Cell Carcinoma

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Anatomical Context for Keratinizing Squamous Cell Carcinoma

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MalaCards organs/tissues related to Keratinizing Squamous Cell Carcinoma:

32
Cervix, Kidney, Liver, Skin

Animal Models for Keratinizing Squamous Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Keratinizing Squamous Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.1KRT8, BCL2

Publications for Keratinizing Squamous Cell Carcinoma

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Articles related to Keratinizing Squamous Cell Carcinoma:

(show all 14)
idTitleAuthorsYear
1
Sinonasal non-keratinizing squamous cell carcinoma with nasal skin extension as the initial presentation. (22775560)
2012
2
Mammary invasive ductal adenocarcinoma and vulvar invasive keratinizing squamous cell carcinoma in a woman with disseminated discoid lupus erythematosus (DDLE) - a case review. (21876498)
2011
3
Rare coexistence of keratinizing squamous cell carcinoma with xanthogranulomatous pyelonephritis in the same kidney: report of two cases. (21119270)
2010
4
Psammoma bodies in cervical smear in association with keratinizing squamous cell carcinoma of cervix: a case report. (19217043)
2009
5
Epidemiology of nasopharyngeal carcinoma in the United States: improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology. (17060483)
2007
6
Keratinizing squamous cell carcinoma of the cervix in a sexually inexperienced woman: a case report. (17039710)
2006
7
Differential expression of anti-apoptotic protein Bcl-2 in keratinizing versus non-keratinizing squamous cell carcinoma of the anus. (15688099)
2005
8
Vulvar keratinizing squamous cell carcinoma in a 26-year-old woman. (11175649)
2001
9
Primary keratinizing squamous cell carcinoma: an exceptional tumor of the gallbladder. (19864815)
1997
10
Case report: primary cystic keratinizing squamous cell carcinoma of the liver in a patient with treated nasopharyngeal carcinoma. (9142640)
1997
11
Basaloid carcinoma and keratinizing squamous cell carcinoma of the vulva: a case of two primary carcinomas. (8572644)
1995
12
Neoplastic cell spreading in rodent transplantable tumor models. II. Santamaria tumor (syngeneic keratinizing squamous cell carcinoma). (2378738)
1990
13
Glandular cell properties of cell line (HKUS) derived from small cell non-keratinizing squamous cell carcinoma of the uterine cervix. (2838556)
1988
14
An adenoid squamous carcinoma-forming cell line established from an oral keratinizing squamous cell carcinoma expressing carcinoembryonic antigen. (2429552)
1986

Variations for Keratinizing Squamous Cell Carcinoma

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Expression for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Expression patterns in normal tissues for genes affiliated with Keratinizing Squamous Cell Carcinoma

Search GEO for disease gene expression data for Keratinizing Squamous Cell Carcinoma.

Pathways for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Compounds for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Compounds related to Keratinizing Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1mitoxantrone44 50 1211.5KRT8, BCL2
2adriamycin449.5KRT8, BCL2
3okadaic acid44 6010.4KRT8, BCL2
4retinoid449.4KRT8, BCL2
5etoposide44 50 60 1212.4BCL2, KRT8
6butyrate449.4KRT8, BCL2
7tamoxifen44 50 29 1212.4KRT8, BCL2
8paclitaxel44 50 1211.4BCL2, KRT8
9doxorubicin44 50 1211.4KRT8, BCL2
10actinomycin d449.4BCL2, KRT8
11paraffin449.3KRT8, BCL2
12genistein44 29 60 3 25 1214.3KRT8, BCL2
13cisplatin44 50 60 1212.3BCL2, KRT8
14cycloheximide449.2KRT8, BCL2
15progesterone44 29 60 25 1213.2BCL2, KRT8
16oligonucleotide449.1KRT8, BCL2
17retinoic acid44 2510.1KRT8, BCL2
18vegf449.0KRT8, BCL2
19estrogen448.8KRT8, BCL2

GO Terms for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Products for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Sources for Keratinizing Squamous Cell Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet