MCID: KRT003
MIFTS: 32

Keratinizing Squamous Cell Carcinoma malady

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Keratinizing Squamous Cell Carcinoma

Aliases & Descriptions for Keratinizing Squamous Cell Carcinoma:

Name: Keratinizing Squamous Cell Carcinoma 12 14
Squamous Cell Carcinoma, Keratinizing 12 69
Keratinizing Epidermoid Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5521
NCIt 47 C4105
SNOMED-CT 64 18048008 189568009
UMLS 69 C0334247

Summaries for Keratinizing Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that presents as single, isolated cells with bizzare cytoplasmic shapes, intense cytoplasmic eosinophilia, and intensely hyperchromatic, angular nuclei in a background of necrotic and keratinous debris.

MalaCards based summary : Keratinizing Squamous Cell Carcinoma, also known as squamous cell carcinoma, keratinizing, is related to vulvar keratinizing squamous cell carcinoma and cervical keratinizing squamous cell carcinoma. An important gene associated with Keratinizing Squamous Cell Carcinoma is CLSTN2 (Calsyntenin 2), and among its related pathways/superpathways are Bladder cancer and Platinum drug resistance. The drugs Cetuximab and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include cervix, skin and liver.

Related Diseases for Keratinizing Squamous Cell Carcinoma

Diseases related to Keratinizing Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
id Related Disease Score Top Affiliating Genes
1 vulvar keratinizing squamous cell carcinoma 12.3
2 cervical keratinizing squamous cell carcinoma 12.2
3 vulvar non-keratinizing squamous cell carcinoma 12.1
4 cervical non-keratinizing squamous cell carcinoma 12.1
5 basaloid squamous cell carcinoma 11.0
6 squamous cell carcinoma 10.4
7 clear cell adenofibroma 10.2 CDKN2A TP53
8 lacrimal gland adenoid cystic carcinoma 10.2 CDKN2A TP53
9 pericardium leiomyoma 10.2 CDKN2A TP53
10 spondylarthropathy 10.2 CDKN2A TP53
11 endometrial squamous cell carcinoma 10.2 CDKN2A TP53
12 ampulla of vater neoplasm 10.2 CDKN2A TP53
13 coccidiosis 10.2 CDKN2A TP53
14 postpoliomyelitis syndrome 10.2 CDKN2A TP53
15 paraphimosis 10.2 CDKN2A TP53
16 anal carcinoma in situ 10.2 CDKN2A TP53
17 oro-mandibular-limb hypogenesis syndrome 10.2 CDKN2A TP53
18 brain stem medulloblastoma 10.2 CDKN2A TP53
19 uterine disease 10.2 CDKN2A TP53
20 fragile x-associated tremor/ataxia syndrome 10.2 CDKN2A TP53
21 spastic ataxia 5 10.2 CDKN2A TP53
22 gallbladder pleomorphic giant cell adenocarcinoma 10.2 CDKN2A TP53
23 adult epithelioid sarcoma 10.2 CDKN2A TP53
24 cervical verrucous carcinoma 10.2 CDKN2A TP53
25 uterine cervix leukoplakia 10.2 CDKN2A TP53
26 house allergic alveolitis 10.2 CDKN2A TP53
27 acquired hemangioma 10.2 CDKN2A TP53
28 urethral verrucous carcinoma 10.2 CDKN2A TP53
29 chronic monocytic leukemia 10.2 CDKN2A TP53
30 ossifying fibromyxoid tumor 10.2 CDKN2A TP53
31 aicardi-goutieres syndrome 10.2 CDKN2A TP53
32 secondary hyperparathyroidism of renal origin 10.2 CDKN2A TP53
33 spinal cord oligodendroglioma 10.2 CDKN2A TP53
34 pacinian tumor 10.2 CDKN2A TP53
35 vascular myelopathy 10.2 CDKN2A TP53
36 tamoxifen-related endometrial lesion 10.2 CDKN2A TP53
37 placental site trophoblastic tumor 10.2 CDKN2A TP53
38 myxedema 10.2 CDKN2A TP53
39 granulomatous myositis 10.2 CDKN2A TP53
40 cryoglobulinemia 10.2 CDKN2A TP53
41 allergic contact dermatitis 10.2 CDKN2A TP53
42 sternum lymphoma 10.2 CDKN2A TP53
43 estrogen-receptor positive breast cancer 10.2 CDKN2A TP53
44 pityriasis rosea 10.2 CDKN2A TP53
45 flat ductal epithelial atypia 10.1 CDKN2A TP53
46 nodular cutaneous amyloidosis 10.1 CDKN2A TP53
47 advanced sleep phase syndrome 10.1 CDKN2A TP53
48 interstitial lung disease 10.1 CDKN2A TP53
49 tricuspid valve prolapse 10.1 CDKN2A MAML2
50 mitochondrial encephalomyopathy 10.1 CDKN2A TP53

Graphical network of the top 20 diseases related to Keratinizing Squamous Cell Carcinoma:



Diseases related to Keratinizing Squamous Cell Carcinoma

Symptoms & Phenotypes for Keratinizing Squamous Cell Carcinoma

Drugs & Therapeutics for Keratinizing Squamous Cell Carcinoma

Drugs for Keratinizing Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cetuximab Approved Phase 2,Phase 1 205923-56-4 56842117 2333
2
Everolimus Approved Phase 2 159351-69-6 6442177
3
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
4
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
5
Cediranib Investigational Phase 2 288383-20-0 9933475
6
Maleic acid Experimental Phase 2 110-16-7 444266
7 Protein Kinase Inhibitors Phase 2
8 Anti-Bacterial Agents Phase 2,Phase 1
9 Antibiotics, Antitubercular Phase 2
10 Antibodies Phase 2,Phase 1
11 Antibodies, Monoclonal Phase 2,Phase 1
12 Antifungal Agents Phase 2
13 Anti-Infective Agents Phase 2,Phase 1
14 Immunoglobulins Phase 2,Phase 1
15 Immunosuppressive Agents Phase 2,Phase 1
16
Azacitidine Approved, Investigational Phase 1 320-67-2 9444
17
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
18
Lenalidomide Approved Phase 1 191732-72-6 216326
19 Antimetabolites Phase 1
20 Antimetabolites, Antineoplastic Phase 1
21 Histone Deacetylase Inhibitors Phase 1
22 Angiogenesis Inhibitors Phase 1
23 Angiogenesis Modulating Agents Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Cediranib Maleate in Treating Patients With Recurrent or Newly Diagnosed Metastatic Head and Neck Cancer Completed NCT00458978 Phase 2
2 Temsirolimus With or Without Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Cancer Who Did Not Respond to Previous Therapy Completed NCT01256385 Phase 2
3 Vorinostat and Azacitidine in Treating Patients With Locally Recurrent or Metastatic Nasopharyngeal Cancer or Nasal Natural Killer T-Cell Lymphoma Active, not recruiting NCT00336063 Phase 1
4 Lenalidomide and Cetuximab in Treating Patients With Advanced Colorectal Cancer or Head and Neck Cancer Active, not recruiting NCT01254617 Phase 1
5 Stereotactic Body Radiation Therapy in Treating Patients With High Risk Locally Advanced Head and Neck Cancer Terminated NCT02388932

Search NIH Clinical Center for Keratinizing Squamous Cell Carcinoma

Genetic Tests for Keratinizing Squamous Cell Carcinoma

Anatomical Context for Keratinizing Squamous Cell Carcinoma

MalaCards organs/tissues related to Keratinizing Squamous Cell Carcinoma:

39
Cervix, Skin, Liver, Kidney

Publications for Keratinizing Squamous Cell Carcinoma

Articles related to Keratinizing Squamous Cell Carcinoma:

(show all 15)
id Title Authors Year
1
Carcinoma ex-pleomorphic adenoma of the parotid gland consisting of high-grade salivary duct carcinoma and keratinizing squamous cell carcinoma. ( 25782724 )
2015
2
Sinonasal non-keratinizing squamous cell carcinoma with nasal skin extension as the initial presentation. ( 22775560 )
2012
3
Mammary invasive ductal adenocarcinoma and vulvar invasive keratinizing squamous cell carcinoma in a woman with disseminated discoid lupus erythematosus (DDLE) - a case review. ( 21876498 )
2011
4
Rare coexistence of keratinizing squamous cell carcinoma with xanthogranulomatous pyelonephritis in the same kidney: report of two cases. ( 21119270 )
2010
5
Psammoma bodies in cervical smear in association with keratinizing squamous cell carcinoma of cervix: a case report. ( 19217043 )
2009
6
Epidemiology of nasopharyngeal carcinoma in the United States: improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology. ( 17060483 )
2007
7
Keratinizing squamous cell carcinoma of the cervix in a sexually inexperienced woman: a case report. ( 17039710 )
2006
8
Differential expression of anti-apoptotic protein Bcl-2 in keratinizing versus non-keratinizing squamous cell carcinoma of the anus. ( 15688099 )
2005
9
Vulvar keratinizing squamous cell carcinoma in a 26-year-old woman. ( 11175649 )
2001
10
Primary keratinizing squamous cell carcinoma: an exceptional tumor of the gallbladder. ( 19864815 )
1997
11
Case report: primary cystic keratinizing squamous cell carcinoma of the liver in a patient with treated nasopharyngeal carcinoma. ( 9142640 )
1997
12
Basaloid carcinoma and keratinizing squamous cell carcinoma of the vulva: a case of two primary carcinomas. ( 8572644 )
1995
13
Neoplastic cell spreading in rodent transplantable tumor models. II. Santamaria tumor (syngeneic keratinizing squamous cell carcinoma). ( 2378738 )
1990
14
Glandular cell properties of cell line (HKUS) derived from small cell non-keratinizing squamous cell carcinoma of the uterine cervix. ( 2838556 )
1988
15
An adenoid squamous carcinoma-forming cell line established from an oral keratinizing squamous cell carcinoma expressing carcinoembryonic antigen. ( 2429552 )
1986

Variations for Keratinizing Squamous Cell Carcinoma

Expression for Keratinizing Squamous Cell Carcinoma

Search GEO for disease gene expression data for Keratinizing Squamous Cell Carcinoma.

Pathways for Keratinizing Squamous Cell Carcinoma

GO Terms for Keratinizing Squamous Cell Carcinoma

Biological processes related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 8.96 CDKN2A TP53
2 replicative senescence GO:0090399 8.62 CDKN2A TP53

Sources for Keratinizing Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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