MCID: KRT003
MIFTS: 37

Keratinizing Squamous Cell Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Keratinizing Squamous Cell Carcinoma

MalaCards integrated aliases for Keratinizing Squamous Cell Carcinoma:

Name: Keratinizing Squamous Cell Carcinoma 12 14
Squamous Cell Carcinoma, Keratinizing 12 69
Keratinizing Epidermoid Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5521
NCIt 46 C4105
SNOMED-CT 64 18048008 189568009
UMLS 69 C0334247

Summaries for Keratinizing Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that presents as single, isolated cells with bizzare cytoplasmic shapes, intense cytoplasmic eosinophilia, and intensely hyperchromatic, angular nuclei in a background of necrotic and keratinous debris.

MalaCards based summary : Keratinizing Squamous Cell Carcinoma, also known as squamous cell carcinoma, keratinizing, is related to basaloid squamous cell carcinoma and vulvar keratinizing squamous cell carcinoma. An important gene associated with Keratinizing Squamous Cell Carcinoma is KRT5 (Keratin 5), and among its related pathways/superpathways are Bladder cancer and Platinum drug resistance. The drugs Cisplatin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include t cells, endothelial and cervix.

Related Diseases for Keratinizing Squamous Cell Carcinoma

Diseases related to Keratinizing Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 basaloid squamous cell carcinoma 31.9 CDKN2A TP53
2 vulvar keratinizing squamous cell carcinoma 12.4
3 cervical keratinizing squamous cell carcinoma 12.3
4 vulvar non-keratinizing squamous cell carcinoma 12.3
5 cervical non-keratinizing squamous cell carcinoma 12.3
6 squamous cell carcinoma 10.4
7 inverted transitional papilloma 10.4 CDKN2A KRT5
8 optic nerve sheath meningioma 10.4 CDKN2A KRT5
9 anal canal squamous cell carcinoma 10.4 CDKN2A KRT5
10 cervical clear cell adenocarcinoma 10.4 CDKN2A KRT5
11 nasal cavity squamous cell carcinoma 10.3 CDKN2A KRT5
12 pleural cancer 10.3 CDKN2A KRT5
13 anus cancer 10.3 CDKN2A KRT5
14 malignant spiradenoma 10.2 KRT5 TP53
15 sarcomatoid squamous cell skin carcinoma 10.2 KRT5 TP53
16 brain stem astrocytic neoplasm 10.2 CDKN2A TP53
17 squamous cell carcinoma of the oropharynx 10.2 CDKN2A TP53
18 spitz nevus 10.2 CDKN2A TP53
19 squamous cell carcinoma of the larynx 10.2 CDKN2A TP53
20 epidural neoplasm 10.2 KRT5 TP53
21 bartholin's gland benign neoplasm 10.2 CDKN2A TP53
22 bladder carcinoma in situ 10.2 CDKN2A TP53
23 anal squamous cell carcinoma 10.2 CDKN2A TP53
24 thyroid lymphoma 10.2 CDKN2A TP53
25 vulva squamous cell carcinoma 10.2 CDKN2A TP53
26 nasal cavity adenocarcinoma 10.2 CDKN2A TP53
27 bone squamous cell carcinoma 10.2 CDKN2A TP53
28 mixed cell type cancer 10.2 KRT5 TP53
29 megaesophagus 10.2 CDKN2A TP53
30 scrotal carcinoma 10.2 CDKN2A TP53
31 glycogen-rich clear cell breast carcinoma 10.2 CDKN2A TP53
32 oral leukoplakia 10.2 CDKN2A TP53
33 anogenital venereal wart 10.2 CDKN2A TP53
34 balanitis xerotica obliterans 10.2 CDKN2A TP53
35 cervix uteri carcinoma in situ 10.2 CDKN2A TP53
36 small cell neuroendocrine carcinoma 10.2 CDKN2A TP53
37 meningeal melanomatosis 10.2 CDKN2A TP53
38 dedifferentiated liposarcoma 10.2 CDKN2A TP53
39 suppressor of tumorigenicity 3 10.2 CDKN2A TP53
40 bladder squamous cell carcinoma 10.2 CDKN2A TP53
41 hidradenocarcinoma 10.2 KRT5 TP53
42 esophagus adenocarcinoma 10.2 CDKN2A TP53
43 breast metaplastic carcinoma 10.2 KRT5 TP53
44 oropharynx cancer 10.2 CDKN2A TP53
45 endocervical adenocarcinoma 10.2 CDKN2A TP53
46 small cell sarcoma 10.2 CDKN2A TP53
47 cervix small cell carcinoma 10.1 CDKN2A TP53
48 sweat gland cancer 10.1 KRT5 TP53
49 biliary tract neoplasm 10.1 CDKN2A TP53
50 inverted papilloma 10.1 CDKN2A TP53

Graphical network of the top 20 diseases related to Keratinizing Squamous Cell Carcinoma:



Diseases related to Keratinizing Squamous Cell Carcinoma

Symptoms & Phenotypes for Keratinizing Squamous Cell Carcinoma

Drugs & Therapeutics for Keratinizing Squamous Cell Carcinoma

Drugs for Keratinizing Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
2
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
3
Cetuximab Approved Phase 2,Phase 1 205923-56-4 56842117 2333
4
Everolimus Approved Phase 2 159351-69-6 6442177
5
Bevacizumab Approved, Investigational Phase 2 216974-75-3
6
Fluorouracil Approved Phase 2 51-21-8 3385
7
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
8
Maleic acid Experimental Phase 2 110-16-7 444266
9
Cediranib Investigational Phase 2 288383-20-0 9933475
10 Mitogens Phase 2
11 Angiogenesis Inhibitors Phase 2,Phase 1
12 Angiogenesis Modulating Agents Phase 2,Phase 1
13 Antibodies, Monoclonal Phase 2,Phase 1
14 Endothelial Growth Factors Phase 2
15 Anti-Bacterial Agents Phase 2,Phase 1
16 Anti-Infective Agents Phase 2,Phase 1
17 Antifungal Agents Phase 2
18 Immunoglobulins Phase 2,Phase 1
19 Immunosuppressive Agents Phase 2,Phase 1
20 Antimetabolites Phase 2,Phase 1
21 Antimetabolites, Antineoplastic Phase 2,Phase 1
22 Protein Kinase Inhibitors Phase 2
23 Antibiotics, Antitubercular Phase 2
24 Antibodies Phase 2,Phase 1
25
Lenalidomide Approved Phase 1 191732-72-6 216326
26
Azacitidine Approved, Investigational Phase 1 320-67-2 9444
27
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
28 Histone Deacetylase Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bevacizumab, Cisplatin, Radiation Therapy, and Fluorouracil in Treating Patients With Stage IIB, Stage III, Stage IVA, or Stage IVB Nasopharyngeal Cancer Completed NCT00408694 Phase 2 Cisplatin;Fluorouracil
2 Temsirolimus With or Without Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Cancer Who Did Not Respond to Previous Therapy Completed NCT01256385 Phase 2 Temsirolimus
3 Cediranib Maleate in Treating Patients With Recurrent or Newly Diagnosed Metastatic Head and Neck Cancer Completed NCT00458978 Phase 2 Cediranib Maleate
4 Ficlatuzumab With or Without Cetuximab in Treating Patients With Cetuximab-Resistant, Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Recruiting NCT03422536 Phase 2 Ficlatuzumab
5 Vorinostat and Azacitidine in Treating Patients With Locally Recurrent or Metastatic Nasopharyngeal Cancer or Nasal Natural Killer T-Cell Lymphoma Active, not recruiting NCT00336063 Phase 1 Azacitidine;Vorinostat
6 Lenalidomide and Cetuximab in Treating Patients With Advanced Colorectal Cancer or Head and Neck Cancer Active, not recruiting NCT01254617 Phase 1 Lenalidomide
7 Stereotactic Body Radiation Therapy in Treating Patients With High Risk Locally Advanced Head and Neck Cancer Terminated NCT02388932

Search NIH Clinical Center for Keratinizing Squamous Cell Carcinoma

Genetic Tests for Keratinizing Squamous Cell Carcinoma

Anatomical Context for Keratinizing Squamous Cell Carcinoma

MalaCards organs/tissues related to Keratinizing Squamous Cell Carcinoma:

38
T Cells, Endothelial, Cervix, Skin, Liver, Pancreas, Kidney

Publications for Keratinizing Squamous Cell Carcinoma

Articles related to Keratinizing Squamous Cell Carcinoma:

(show all 16)
# Title Authors Year
1
Endosonography and Confocal Endomicroscopy of Primary Keratinizing Squamous Cell Carcinoma of the Pancreas. ( 28184374 )
2017
2
Carcinoma ex-pleomorphic adenoma of the parotid gland consisting of high-grade salivary duct carcinoma and keratinizing squamous cell carcinoma. ( 25782724 )
2015
3
Sinonasal non-keratinizing squamous cell carcinoma with nasal skin extension as the initial presentation. ( 22775560 )
2012
4
Mammary invasive ductal adenocarcinoma and vulvar invasive keratinizing squamous cell carcinoma in a woman with disseminated discoid lupus erythematosus (DDLE) - a case review. ( 21876498 )
2011
5
Rare coexistence of keratinizing squamous cell carcinoma with xanthogranulomatous pyelonephritis in the same kidney: report of two cases. ( 21119270 )
2010
6
Psammoma bodies in cervical smear in association with keratinizing squamous cell carcinoma of cervix: a case report. ( 19217043 )
2009
7
Epidemiology of nasopharyngeal carcinoma in the United States: improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology. ( 17060483 )
2007
8
Keratinizing squamous cell carcinoma of the cervix in a sexually inexperienced woman: a case report. ( 17039710 )
2006
9
Differential expression of anti-apoptotic protein Bcl-2 in keratinizing versus non-keratinizing squamous cell carcinoma of the anus. ( 15688099 )
2005
10
Vulvar keratinizing squamous cell carcinoma in a 26-year-old woman. ( 11175649 )
2001
11
Case report: primary cystic keratinizing squamous cell carcinoma of the liver in a patient with treated nasopharyngeal carcinoma. ( 9142640 )
1997
12
Primary keratinizing squamous cell carcinoma: an exceptional tumor of the gallbladder. ( 19864815 )
1997
13
Basaloid carcinoma and keratinizing squamous cell carcinoma of the vulva: a case of two primary carcinomas. ( 8572644 )
1995
14
Neoplastic cell spreading in rodent transplantable tumor models. II. Santamaria tumor (syngeneic keratinizing squamous cell carcinoma). ( 2378738 )
1990
15
Glandular cell properties of cell line (HKUS) derived from small cell non-keratinizing squamous cell carcinoma of the uterine cervix. ( 2838556 )
1988
16
An adenoid squamous carcinoma-forming cell line established from an oral keratinizing squamous cell carcinoma expressing carcinoembryonic antigen. ( 2429552 )
1986

Variations for Keratinizing Squamous Cell Carcinoma

Expression for Keratinizing Squamous Cell Carcinoma

Search GEO for disease gene expression data for Keratinizing Squamous Cell Carcinoma.

Pathways for Keratinizing Squamous Cell Carcinoma

GO Terms for Keratinizing Squamous Cell Carcinoma

Biological processes related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 9.16 CDKN2A TP53
2 positive regulation of apoptotic process GO:0043065 9.13 AKAP13 CDKN2A TP53
3 replicative senescence GO:0090399 8.62 CDKN2A TP53

Molecular functions related to Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.62 CDKN2A TP53

Sources for Keratinizing Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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