MCID: KRT003
MIFTS: 31

Keratinizing Squamous Cell Carcinoma malady

Skin diseases, Cancer diseases categories

Summaries for Keratinizing Squamous Cell Carcinoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A squamous cell carcinoma that presents as single, isolated cells with bizzare cytoplasmic shapes, intense cytoplasmic eosinophilia, and intensely hyperchromatic, angular nuclei in a background of necrotic and keratinous debris.

MalaCards: Keratinizing Squamous Cell Carcinoma, also known as squamous cell carcinoma, keratinizing, is related to cervical squamous cell carcinoma and squamous cell carcinoma. An important gene associated with Keratinizing Squamous Cell Carcinoma is ANKK1 (ankyrin repeat and kinase domain containing 1). The compounds mitoxantrone and retinoid have been mentioned in the context of this disorder. Affiliated tissues include skin, cervix and lung.

Aliases & Classifications for Keratinizing Squamous Cell Carcinoma

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

keratinizing squamous cell carcinoma 8
squamous cell carcinoma, keratinizing 8 60
keratinizing epidermoid carcinoma 8


External Ids:

Disease Ontology8 DOID:5521
SNOMED-CT56 189568009, 18048008
NCIt39 C4105

Related Diseases for Keratinizing Squamous Cell Carcinoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Keratinizing Squamous Cell Carcinoma:



Diseases related to keratinizing squamous cell carcinoma

Clinical Features for Keratinizing Squamous Cell Carcinoma

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Drugs & Therapeutics for Keratinizing Squamous Cell Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Genetic Tests for Keratinizing Squamous Cell Carcinoma

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Anatomical Context for Keratinizing Squamous Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Keratinizing Squamous Cell Carcinoma:

32
Skin, Cervix, Lung, Liver, Tongue, Kidney

Animal Models for Keratinizing Squamous Cell Carcinoma or affiliated genes

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Publications for Keratinizing Squamous Cell Carcinoma

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50PubMed
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Articles related to Keratinizing Squamous Cell Carcinoma:

(show all 36)
idTitleAuthorsYear
1
Sinonasal non-keratinizing squamous cell carcinoma with nasal skin extension as the initial presentation. (22775560)
2012
2
Keratin 8 expression in mouth mucosa hyperkeratosis and squamous cell carcinoma ]. (22379894)
2011
3
Down-regulation of keratin 4 and keratin 13 expression in oral squamous cell carcinoma and epithelial dysplasia: a clue for histopathogenesis. (21371075)
2011
4
Mammary invasive ductal adenocarcinoma and vulvar invasive keratinizing squamous cell carcinoma in a woman with disseminated discoid lupus erythematosus (DDLE) - a case review. (21876498)
2011
5
A novel homozygous keratin 14 mutation in a patient with autosomal recessive epidermolysis bullosa simplex and squamous cell carcinoma of the tongue. (20096008)
2010
6
Rare coexistence of keratinizing squamous cell carcinoma with xanthogranulomatous pyelonephritis in the same kidney: report of two cases. (21119270)
2010
7
Ectopic coexpression of keratin 8 and 18 promotes invasion of transformed keratinocytes and is induced in patients with cutaneous squamous cell carcinoma. (20659422)
2010
8
Psammoma bodies in cervical smear in association with keratinizing squamous cell carcinoma of cervix: a case report. (19217043)
2009
9
Epidemiology of nasopharyngeal carcinoma in the United States: improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology. (17060483)
2007
10
DeltaNp63 isoforms regulate CD44 and keratins 4, 6, 14 and 19 in squamous cell carcinoma of head and neck. (17935121)
2007
11
Keratinizing squamous cell carcinoma of the cervix in a sexually inexperienced woman: a case report. (17039710)
2006
12
Differential expression of anti-apoptotic protein Bcl-2 in keratinizing versus non-keratinizing squamous cell carcinoma of the anus. (15688099)
2005
13
Complex formations involving both SP-1 and SP-3 at the transcriptional regulatory sequence correlate with the activation of the Keratin 14 gene in human oral squamous cell carcinoma cells. (16273259)
2005
14
Presence and type of oncogenic human papillomavirus in classic and in differentiated vulvar intraepithelial neoplasia and keratinizing vulvar squamous cell carcinoma. (16032717)
2005
15
Cell proliferation patterns in canine infundibular keratinizing acanthoma and well differentiated squamous cell carcinoma of the skin. (12152794)
2002
16
Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin patterns. (12459626)
2002
17
Vulvar keratinizing squamous cell carcinoma in a 26-year-old woman. (11175649)
2001
18
Morphologic and molecular-genetic characteristics of keratinization and apoptosis in squamous cell lung carcinoma]. (10897431)
2000
19
Expression of retinoic acid receptor beta is associated with inhibition of keratinization in human head and neck squamous carcinoma cells. (10234809)
1999
20
Keratin 19 downregulation by oral squamous cell carcinoma lines increases invasive potential. (10371250)
1999
21
The limited difference between keratin patterns of squamous cell carcinomas and adenocarcinomas is explicable by both cell lineage and state of differentiation of tumour cells. (9930073)
1998
22
Expression of keratin 13, 14 and 19 in oral squamous cell carcinomas from Sudanese snuff dippers: lack of association with human papillomavirus infection. (9833698)
1998
23
Primary keratinizing squamous cell carcinoma: an exceptional tumor of the gallbladder. (19864815)
1997
24
Case report: primary cystic keratinizing squamous cell carcinoma of the liver in a patient with treated nasopharyngeal carcinoma. (9142640)
1997
25
Basaloid carcinoma and keratinizing squamous cell carcinoma of the vulva: a case of two primary carcinomas. (8572644)
1995
26
Keratins 6, 13 and 19. Differential expression in squamous cell carcinoma of the head and neck. (7505082)
1993
27
Marked reduction of type I keratin (K14) in cisplatin-resistant human lung squamous-carcinoma cell lines. (7683471)
1993
28
Keratin expression in normal vulva, non-neoplastic epithelial disorders, vulvar intraepithelial neoplasia, and invasive squamous cell carcinoma. (1723057)
1991
29
Abnormal expression of retinoic acid receptors and keratin 19 by human oral and epidermal squamous cell carcinoma cell lines. (1713123)
1991
30
Retinoid-mediated transcriptional regulation of keratin genes in human epidermal and squamous cell carcinoma cells. (1711202)
1991
31
Neoplastic cell spreading in rodent transplantable tumor models. II. Santamaria tumor (syngeneic keratinizing squamous cell carcinoma). (2378738)
1990
32
The coexpression of keratin and vimentin in untreated squamous cell carcinoma of the ENT tract]. (1705125)
1990
33
Glandular cell properties of cell line (HKUS) derived from small cell non-keratinizing squamous cell carcinoma of the uterine cervix. (2838556)
1988
34
The expression of mutant epidermal keratin cDNAs transfected in simple epithelial and squamous cell carcinoma lines. (2442174)
1987
35
An adenoid squamous carcinoma-forming cell line established from an oral keratinizing squamous cell carcinoma expressing carcinoembryonic antigen. (2429552)
1986
36
Keratoacanthoma and squamous cell carcinoma of the skin: immunohistochemical localization of involucrin and keratin proteins. (2419374)
1986

Genetic Variations for Keratinizing Squamous Cell Carcinoma

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Expression for genes affiliated with Keratinizing Squamous Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Pathways for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Compounds for genes affiliated with Keratinizing Squamous Cell Carcinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Keratinizing Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mitoxantrone44 49 1111.0BCL2, KRT8
2retinoid449.0BCL2, KRT8
3adriamycin448.9BCL2, KRT8
4okadaic acid44 599.7BCL2, KRT8

GO Terms for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Products for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Sources for Keratinizing Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet