MCID: KRT003
MIFTS: 32

Keratinizing Squamous Cell Carcinoma malady

Cancer diseases, Skin diseases categories

Summaries for Keratinizing Squamous Cell Carcinoma

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 A squamous cell carcinoma that presents as single, isolated cells with bizzare cytoplasmic shapes, intense cytoplasmic eosinophilia, and intensely hyperchromatic, angular nuclei in a background of necrotic and keratinous debris.

MalaCards: Keratinizing Squamous Cell Carcinoma, also known as squamous cell carcinoma, keratinizing, is related to adenocarcinoma and vulvar keratinizing squamous cell carcinoma. An important gene associated with Keratinizing Squamous Cell Carcinoma is KRT8 (keratin 8). The compounds mitoxantrone and adriamycin have been mentioned in the context of this disorder. Affiliated tissues include cervix, skin and liver, and related mouse phenotype digestive/alimentary.

Aliases & Classifications for Keratinizing Squamous Cell Carcinoma

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9Disease Ontology, 63UMLS, 41NCIt, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

keratinizing squamous cell carcinoma 9
squamous cell carcinoma, keratinizing 9 63
keratinizing epidermoid carcinoma 9


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Disease Ontology9 DOID:5521
SNOMED-CT59 189568009, 18048008
NCIt41 C4105

Related Diseases for Keratinizing Squamous Cell Carcinoma

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Keratinizing Squamous Cell Carcinoma:



Diseases related to keratinizing squamous cell carcinoma

Symptoms for Keratinizing Squamous Cell Carcinoma

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Drugs & Therapeutics for Keratinizing Squamous Cell Carcinoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Keratinizing Squamous Cell Carcinoma

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Anatomical Context for Keratinizing Squamous Cell Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Keratinizing Squamous Cell Carcinoma:

34
Cervix, Skin, Liver

Animal Models for Keratinizing Squamous Cell Carcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Keratinizing Squamous Cell Carcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.1KRT8, BCL2

Publications for Keratinizing Squamous Cell Carcinoma

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53PubMed
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Articles related to Keratinizing Squamous Cell Carcinoma:

(show all 13)
idTitleAuthorsYear
1
Sinonasal non-keratinizing squamous cell carcinoma with nasal skin extension as the initial presentation. (22775560)
2012
2
Mammary invasive ductal adenocarcinoma and vulvar invasive keratinizing squamous cell carcinoma in a woman with disseminated discoid lupus erythematosus (DDLE) - a case review. (21876498)
2011
3
Psammoma bodies in cervical smear in association with keratinizing squamous cell carcinoma of cervix: a case report. (19217043)
2009
4
Epidemiology of nasopharyngeal carcinoma in the United States: improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology. (17060483)
2007
5
Keratinizing squamous cell carcinoma of the cervix in a sexually inexperienced woman: a case report. (17039710)
2006
6
Differential expression of anti-apoptotic protein Bcl-2 in keratinizing versus non-keratinizing squamous cell carcinoma of the anus. (15688099)
2005
7
Vulvar keratinizing squamous cell carcinoma in a 26-year-old woman. (11175649)
2001
8
Primary keratinizing squamous cell carcinoma: an exceptional tumor of the gallbladder. (19864815)
1997
9
Case report: primary cystic keratinizing squamous cell carcinoma of the liver in a patient with treated nasopharyngeal carcinoma. (9142640)
1997
10
Basaloid carcinoma and keratinizing squamous cell carcinoma of the vulva: a case of two primary carcinomas. (8572644)
1995
11
Neoplastic cell spreading in rodent transplantable tumor models. II. Santamaria tumor (syngeneic keratinizing squamous cell carcinoma). (2378738)
1990
12
Glandular cell properties of cell line (HKUS) derived from small cell non-keratinizing squamous cell carcinoma of the uterine cervix. (2838556)
1988
13
An adenoid squamous carcinoma-forming cell line established from an oral keratinizing squamous cell carcinoma expressing carcinoembryonic antigen. (2429552)
1986

Variations for Keratinizing Squamous Cell Carcinoma

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Expression for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Pathways for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Compounds for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 3BitterDB, 25HMDB
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Compounds related to Keratinizing Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1mitoxantrone46 52 1211.5KRT8, BCL2
2adriamycin469.5KRT8, BCL2
3okadaic acid46 6210.4KRT8, BCL2
4retinoid469.4KRT8, BCL2
5etoposide46 52 62 1212.4BCL2, KRT8
6butyrate469.4KRT8, BCL2
7tamoxifen46 52 30 1212.4KRT8, BCL2
8paclitaxel46 52 1211.4BCL2, KRT8
9doxorubicin46 52 1211.4KRT8, BCL2
10actinomycin d469.4BCL2, KRT8
11paraffin469.3KRT8, BCL2
12genistein46 30 62 3 25 1214.3KRT8, BCL2
13cisplatin46 52 62 1212.3BCL2, KRT8
14cycloheximide469.2KRT8, BCL2
15progesterone46 30 62 25 1213.2BCL2, KRT8
16oligonucleotide469.1KRT8, BCL2
17retinoic acid46 2510.1KRT8, BCL2
18vegf469.0KRT8, BCL2
19estrogen468.8KRT8, BCL2

GO Terms for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Products for genes affiliated with Keratinizing Squamous Cell Carcinoma

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Sources for Keratinizing Squamous Cell Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet