MCID: KRT004
MIFTS: 66

Keratitis malady

Eye diseases category

Summaries for Keratitis

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Keratitis is a condition in which the eye\'s cornea, the front part of the eye, becomes inflamed. The... more...

MalaCards: Keratitis, also known as autosomal dominant keratitis, is related to herpes simplex and keratopathy. An important gene associated with Keratitis is PAX6 (paired box 6), and among its related pathways are PEDF Induced Signaling and Rho Family GTPases. The drugs tropicamide and loteprednol etabonate and the compounds rantes and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related mouse phenotype immune system.

Description from OMIM:46 148190

Aliases & Classifications for Keratitis

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Sources:
8Disease Ontology, 9diseasecard, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 48Orphanet, 39NCIt, 56SNOMED-CT, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Characteristics (Orphanet epidemiological data):

48
autosomal dominant keratitis:
Inheritance: Autosomal dominant; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

keratitis 8 9 46 10 44 60
autosomal dominant keratitis 48
unspecified keratitis 8
keratitis, hereditary 60
hereditary keratitis 48
keratitis nos 8


External Ids:

Disease Ontology8 DOID:4677
NCIt39 C26805
ICD9CM27 370.9, 370
MeSH34 D007634
OMIM46 148190
MESH via Orphanet35 C537022
ICD10 via Orphanet26 H16.8
UMLS via Orphanet61 C1835698
ICD1025 H16, H16.9

Related Diseases for Keratitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Keratitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 318)
idRelated DiseaseScoreTop Affiliating Genes
1herpes simplex31.3TLR9, DARC, GJB2, TKT
2keratopathy30.5PAX6, PBK
3uveitis30.4CD69, CXCL9, IL17A
4arthritis30.2CCL20, CD69, CXCL1, CXCL2, CXCL9, IL17RA
5rheumatoid arthritis30.1CCR6, CCL20, TLR9, CD69, CXCL1, CXCL9
6pneumonia30.1IL17A, CXCL2, CXCL1, DEFB4A
7candidiasis30.1DEFB4A
8squamous cell carcinoma30.1CCR6, DEFB4A, CXCL1, CXCL9, GJB2, TKT
9tuberculosis30.0TLR9, DEFB4A, CD69, CXCL9, IL17A, TKT
10sarcoidosis30.0DEFB4A, CD69, CXCL9
11lupus erythematosus30.0TLR9
12systemic lupus erythematosus30.0IL17A, CD69, TNFSF4, TLR9
13hepatitis29.8TKT
14leukemia29.8PAX6, CCR6, CCL20, TNFSF4, CXCL1, CXCL2
15vaccinia29.8DARC
16malaria29.8DARC, CXCL9, TLR9
17atopic dermatitis29.6CCL20, TLR9, DEFB4A, CD69, CXCL9, IL17A
18dermatitis29.6IL17A, CXCL9, TLR9
19peritonitis29.6CXCL2, CD69
20inflammatory bowel disease29.6DARC, IL17A, CXCL1, DEFB4A, CCL20
21atherosclerosis29.6TLR9, CXCL1, CXCL9, IL17A
22hepatitis c29.6CCL20
23ischemia29.6CD69, CXCL2, IL17A, PAX6
24meningitis29.6CXCL1
25sjogren's syndrome29.6CXCL9
26vasculitis29.6TNFSF4, CXCL1, IL17A
27interstitial keratitis10.8
28superficial keratitis10.6
29filamentary keratitis10.5
30deep keratitis10.5
31exposure keratitis10.4
32corneal ulcer10.4
33keratoconjunctivitis10.4
34scleritis10.4
35conjunctivitis10.4
36kid syndrome10.4
37eye disease10.3
38glaucoma10.3
39endophthalmitis10.3
40syphilis10.3
41iritis10.3
42herpes zoster10.2
43sclerosing keratitis10.2
44corneal neovascularization10.2
45hypopyon10.2
46iridocyclitis10.2
47corneal disease10.2
48cataract10.2
49macular keratitis10.1
50bacterial conjunctivitis10.1

Graphical network of the top 20 diseases related to Keratitis:



Diseases related to keratitis

Clinical Features for Keratitis

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Sources:
46OMIM
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Clinical features from OMIM:

148190

Clinical synopsis from OMIM:

148190

Drugs & Therapeutics for Keratitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Keratitis

Drug clinical trials:

Search ClinicalTrials for Keratitis

Search NIH Clinical Center for Keratitis

Search CenterWatch for Keratitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Keratitis

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Anatomical Context for Keratitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Keratitis:

32
Eye, T cells, Endothelial, Testes, B cells, Skin, Liver, Retina, Lymph node, Thyroid, Brain, Bone, Bone marrow

Animal Models for Keratitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Keratitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.7PAX6, TLR9, TNFSF4, KERA, AIMP1, CD69

Publications for Keratitis

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Sources:
50PubMed
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Articles related to Keratitis:

(show top 50)    (show all 1894)
idTitleAuthorsYear
1
Inhibition of Ataxia Telangiectasia Mutated (ATM) Kinase Suppresses Herpes Simplex Virus Type 1 (HSV-1) Keratitis. (24370835)
2013
2
Semipermanent eyelash extensions causing bacterial keratitis: a case report. (23769794)
2013
3
Acanthamoeba genotype T4 detected in naturally-infected feline corneas found to be in homology with those causing human keratitis. (23665719)
2013
4
Genotyping and phylogenetic analysis of Acanthamoeba isolates associated with keratitis. (23959385)
2013
5
Keratitis-induced endophthalmitis. (23823526)
2013
6
Acanthamoeba keratitis-An increasing incidence. (24177033)
2013
7
Dolosigranulum pigrum keratitis: a three-case series. (23841940)
2013
8
Results of case-control studies support the association between contact lens use and Acanthamoeba keratitis. (23761962)
2013
9
Heterozygous p.Asp50Asn mutation in the GJB2 gene in two Cameroonian patients with keratitis-ichthyosis-deafness (KID) syndrome. (23924173)
2013
10
Characterization of fungal keratitis in alpacas: 11 cases (2003-2012). (24261813)
2013
11
Rapid diagnosis of acanthamoeba keratitis using non-nutrient agar with a lawn of E. coli. (23514313)
2013
12
Chronic recalcitrant bacterial infection in steroid modified interstitial (stromal) keratitis: presentation and management. (23252209)
2012
13
Differentiation of etiologic agents of bacterial keratitis from presentation characteristics. (22752605)
2012
14
Possible modifier effects of keratin 17 gene mutation on keratitis-ichthyosis-deafness syndrome. (21999526)
2012
15
Differentiation between infectious and noninfectious ulcerative keratitis by Raman spectra of human teardrops: a pilot study. (22297490)
2012
16
Chronic granulomatous disease and serious unilateral keratitis with bilateral conjunctivitis: a rare case of external ocular disease. (20163362)
2011
17
Nocardia transvalensis keratitis: an emerging pathology among travelers returning from Asia. (22040176)
2011
18
Acanthamoeba keratitis--a diagnostic challenge. (22288216)
2011
19
Clinical course and management of postoperative methicillin-resistant Staphylococcus aureus keratitis in immunocompromised patients: two case reports. (22267913)
2011
20
Lens epithelial cell death secondary to acanthamoeba keratitis: absence of capsular bag opacification six years after cataract surgery. (22220159)
2011
21
TLR9 and HBD-2 gene expression by conjunctival and corneal cells in children with dendriform herpetic keratitis]. (21328884)
2010
22
Slitlamp biomicroscopy and photographic image analysis of herpes simplex virus stromal keratitis. (19204233)
2009
23
Non-mitogenic anti-CD3F(ab')2 monoclonal antibody: a novel approach to control herpetic stromal keratitis. (18689698)
2008
24
A-5021: a new acyclovir analogue inhibits murine herpetic keratitis. (18362663)
2008
25
Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis. (17963106)
2007
26
A study of the spectrum of Acanthamoeba keratitis: a three-year study at a tertiary eye care referral center in South India. (17189885)
2007
27
Acanthamoeba keratitis in non-contact lens wearers in India: DNA typing-based validation and a simple detection assay. (15477452)
2004
28
Effect of oral acyclovir after penetrating keratoplasty for herpetic keratitis: a placebo-controlled multicenter trial. (14522763)
2003
29
Acanthamoeba keratitis: a review. (10670164)
1999
30
Are cytokine patterns in aqueous humour useful in distinguishing corneal graft rejection from opacification due to herpetic stromal keratitis? (11097120)
1999
31
Mycobacterium chelonae keratitis after excimer laser photorefractive keratectomy. (9338681)
1997
32
Acanthamoeba keratitis. (7712613)
1995
33
Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-gamma knockout mice. (7561104)
1995
34
Comparison of topical cyclosporin and dexamethasone for the treatment of chronic superficial keratitis in dogs. (8693674)
1995
35
Herpetic stromal keratitis in the reconstituted scid mouse model. (8098778)
1993
36
Examination of the contact lens with light microscopy: an aid in diagnosis of Acanthamoeba keratitis. (2047685)
1991
37
Effects of 9-(1,3-dihydroxy-2-propoxymethyl) guanine (DHPG) eye drops and cyclosporine eye drops in the treatment of herpetic stromal keratitis in rabbits. (1650668)
1991
38
Laboratory investigation of Acanthamoeba keratitis. (1980681)
1990
39
Corneal effect of isotretinoin: possible exacerbation of corneal neovascularization in a patient with the keratitis, ichthyosis, deafness ("KID") syndrome. (2419373)
1986
40
Eledoisin--a successful therapeutic concept for filamentary keratitis. (3862278)
1985
41
Experimental herpetic keratitis in rabbit corneal organ cultures. (6320856)
1984
42
Surgical management of herpetic keratitis. (7020218)
1981
43
Collagenase levels in a new model of experimental herpetic interstitial keratitis. (6246865)
1980
44
Study of filamentary keratitis by replica technique. (380383)
1979
45
A controlled trial of adenine arabinoside and trifluorothymidine in herpetic keratitis. (415912)
1978
46
Tyrosinemia with plantar and palmar keratosis and keratitis. (4270265)
1973
47
The corneal stroma in experimental herpetic keratitis in rabbits. (4103622)
1971
48
Superficial forms of herpetic keratitis. (13411141)
1957
49
Some aspects of interstitial keratitis. (15410175)
1950
50
A Preliminary Report on the Treatment of Interstitial Keratitis. (19983969)
1924

Genetic Variations for Keratitis

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Expression for genes affiliated with Keratitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratitis

Search GEO for disease gene expression data for Keratitis.

Pathways for genes affiliated with Keratitis

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Sources:
51QIAGEN, 29KEGG, 53Reactome, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Keratitis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6CCR6, CCL20, TNFSF4, CXCL1, CXCL2, CXCL9
2
Hide members
10.6CCR6, CCL20, TNFSF4, CXCL1, CXCL2, CXCL9
3
Hide members
10.5CCR6, CCL20, TLR9, TNFSF4, CXCL1, CXCL2
4
Hide members
10.5CCR6, CCL20, TNFSF4, CXCL1, CXCL2, CXCL9
5
Hide members
10.5CCR6, CCL20, CXCL1, CXCL2, CXCL9, DARC
6
Hide members
10.5IL17A, IL17RA, TLR9
710.5CXCL9, CXCL2, CXCL1, CCL20, CCR6
8
Hide members
10.5CCR6, CCL20, CXCL1, CXCL2, CXCL9
9
Hide members
10.5CCR6, CCL20, CXCL1, CXCL2, CXCL9
10
Cytokine production by Th17 cells in CF (Mouse model)
10.5CXCL1, IL17RA, IL17A
1110.5IL17A, CXCL1, CCL20
1210.5CXCL2, CXCL1, CCL20

Compounds for genes affiliated with Keratitis

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Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Keratitis according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1rantes4410.9DARC, CCR6, CCL20, DEFB4A, CXCL1, CXCL2
2endotoxin4410.9CCL20, TLR9, DEFB4A, CXCL1, CXCL2, CXCL9
3vegf4410.9CCR6, CCL20, CXCL1, CXCL2, CXCL9, IL17A
4ccl444 2811.9CCR6, CCL20, CXCL2, CXCL9, IL17A
5tarc4410.9CCR6, CCL20, CXCL1, CXCL2, CXCL9
6lipid4410.9LCN1, CCR6, DEFB4A, CD69, CXCL2, IL17A
7ccl344 2811.9CXCL9, CXCL2, CXCL1, TLR9, CCL20
8calcium44 49 11 2413.9LCN1, CCR6, CCL20, DEFB4A, CD69, CXCL1
9nitric oxide44 11 2412.9CCL20, TLR9, CD69, CXCL1, CXCL2, CXCL9
10groalpha4410.9CXCL1, CXCL2, CXCL9, IL17A
11dexamethasone44 49 28 1113.8CCL20, DEFB4A, CXCL1, CXCL2, CXCL9
12tyrosine4410.8TLR9, DEFB4A, CD69, CXCL1, CXCL2, CXCL9
13flagellin44 2811.8CCL20, TLR9, DEFB4A
14pd 98,0594410.8DEFB4A, CD69, CXCL1, CXCL2, IL17A
15mip-3alpha4410.8CCL20, CCR6
16poly(i-c)4410.7CCL20, TLR9, CD69
17peptidoglycan44 2811.7DEFB4A, TLR9, CCL20
18methotrexate44 49 1112.7CD69, CXCL1, IL17A, TKT
19creatinine4410.7LCN1, CD69, CXCL9, IL17A, TKT
20grogamma4410.6CXCL2, CXCL1
21sb 20358044 5911.6DEFB4A, CXCL1, CXCL2, IL17A
22larc4410.5CCL20, CCR6
23grobeta4410.5CXCL2, CXCL1
24sp 60012544 5911.4IL17A, CXCL2, DEFB4A
25oligonucleotide4410.2CCL20, TLR9, CXCL1, CXCL2, IL17A

GO Terms for genes affiliated with Keratitis

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Sources:
16Gene Ontology
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Cellular components related to Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6CCL20, TLR9, KERA, DEFB4A, CXCL1, CXCL2
2extracellular spaceGO:00561510.3IL17A, CCL20, TNFSF4, AIMP1, CXCL1, CXCL2

Biological processes related to Keratitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.8CXCL9, CCR6, CCL20, DEFB4A, AIMP1, CXCL1
2inflammatory responseGO:00695410.8CCL20, TLR9, AIMP1, CXCL1, CXCL2, CXCL9
3immune responseGO:00695510.8CCR6, CCL20, DEFB4A, CXCL1, CXCL2, CXCL9
4cell-cell signalingGO:00726710.7CCL20, AIMP1, CXCL9, IL17A, GJB2
5fibroblast activationGO:07253710.7IL17A, IL17RA
6positive regulation of interleukin-23 productionGO:03274710.7IL17RA, IL17A
7positive regulation of cytokine production involved in inflammatory responseGO:190001710.6IL17A, IL17RA
8response to molecule of bacterial originGO:00223710.6CXCL2, TLR9
9cornea development in camera-type eyeGO:06130310.5KERA, PAX6
10positive regulation of interleukin-10 productionGO:03273310.5TNFSF4, TLR9
11signal transductionGO:00716510.4CCR6, CCL20, TNFSF4, AIMP1, CXCL1, CXCL9
12defense response to bacteriumGO:04274210.2DEFB4A, TLR9, CCL20

Molecular functions related to Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.5CXCL9, CXCL2, CXCL1, CCL20
2chemokine receptor activityGO:00495010.5DARC, CCR6
3cytokine activityGO:00512510.4TNFSF4, AIMP1, CXCL9, IL17A
4transmembrane signaling receptor activityGO:00488810.2DARC, CD69, TLR9

Products for genes affiliated with Keratitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Keratitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet