MCID: KRT004
MIFTS: 66

Keratitis malady

Eye diseases category

Summaries for Keratitis

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Keratitis is a condition in which the eye\'s cornea, the front part of the eye, becomes inflamed. The... more...

MalaCards: Keratitis, also known as autosomal dominant keratitis, is related to herpes simplex and keratopathy. An important gene associated with Keratitis is PAX6 (paired box 6), and among its related pathways are PEDF Induced Signaling and Rho Family GTPases. The drugs loteprednol etabonate and loteprednol and the compounds rantes and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related mouse phenotype immune system.

Description from OMIM:46 148190

Aliases & Classifications for Keratitis

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Sources:
8Disease Ontology, 9diseasecard, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 48Orphanet, 39NCIt, 56SNOMED-CT, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Characteristics (Orphanet epidemiological data):

48
autosomal dominant keratitis:
Inheritance: Autosomal dominant; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

keratitis 8 9 46 10 44 60
autosomal dominant keratitis 48
unspecified keratitis 8
keratitis, hereditary 60
hereditary keratitis 48
keratitis nos 8


External Ids:

Disease Ontology8 DOID:4677
NCIt39 C26805
ICD9CM27 370.9, 370
MeSH34 D007634
OMIM46 148190
MESH via Orphanet35 C537022
ICD10 via Orphanet26 H16.8
UMLS via Orphanet61 C1835698
ICD1025 H16, H16.9

Related Diseases for Keratitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Keratitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 318)
idRelated DiseaseScoreTop Affiliating Genes
1herpes simplex31.3TLR9, DARC, GJB2, TKT
2keratopathy30.5PAX6, PBK
3uveitis30.4CD69, CXCL9, IL17A
4arthritis30.2CCL20, CD69, CXCL1, CXCL2, CXCL9, IL17RA
5rheumatoid arthritis30.1CCR6, CCL20, TLR9, CD69, CXCL1, CXCL9
6pneumonia30.1IL17A, CXCL2, CXCL1, DEFB4A
7candidiasis30.1DEFB4A
8squamous cell carcinoma30.1CCR6, DEFB4A, CXCL1, CXCL9, GJB2, TKT
9tuberculosis30.0TLR9, DEFB4A, CD69, CXCL9, IL17A, TKT
10sarcoidosis30.0DEFB4A, CD69, CXCL9
11lupus erythematosus30.0TLR9
12systemic lupus erythematosus30.0IL17A, CD69, TNFSF4, TLR9
13hepatitis29.8TKT
14leukemia29.8PAX6, CCR6, CCL20, TNFSF4, CXCL1, CXCL2
15vaccinia29.8DARC
16malaria29.8DARC, CXCL9, TLR9
17atopic dermatitis29.6CCL20, TLR9, DEFB4A, CD69, CXCL9, IL17A
18dermatitis29.6IL17A, CXCL9, TLR9
19peritonitis29.6CXCL2, CD69
20inflammatory bowel disease29.6DARC, IL17A, CXCL1, DEFB4A, CCL20
21atherosclerosis29.6TLR9, CXCL1, CXCL9, IL17A
22hepatitis c29.6CCL20
23ischemia29.6CD69, CXCL2, IL17A, PAX6
24meningitis29.6CXCL1
25sjogren's syndrome29.6CXCL9
26vasculitis29.6TNFSF4, CXCL1, IL17A
27interstitial keratitis10.8
28superficial keratitis10.6
29filamentary keratitis10.5
30deep keratitis10.5
31exposure keratitis10.4
32corneal ulcer10.4
33keratoconjunctivitis10.4
34scleritis10.4
35conjunctivitis10.4
36kid syndrome10.4
37eye disease10.3
38glaucoma10.3
39endophthalmitis10.3
40syphilis10.3
41iritis10.3
42herpes zoster10.2
43sclerosing keratitis10.2
44corneal neovascularization10.2
45hypopyon10.2
46iridocyclitis10.2
47corneal disease10.2
48cataract10.2
49macular keratitis10.1
50bacterial conjunctivitis10.1

Graphical network of the top 20 diseases related to Keratitis:



Diseases related to keratitis

Clinical Features for Keratitis

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Sources:
46OMIM
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Clinical features from OMIM:

148190

Clinical synopsis from OMIM:

148190

Drugs & Therapeutics for Keratitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Keratitis

Drug clinical trials:

Search ClinicalTrials for Keratitis

Search NIH Clinical Center for Keratitis

Search CenterWatch for Keratitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Keratitis

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Anatomical Context for Keratitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Keratitis:

32
Eye, T cells, Endothelial, Testes, B cells, Lymph node, Liver, Skin, Retina, Brain, Bone marrow, Thyroid, Bone

Animal Models for Keratitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Keratitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.7PAX6, TLR9, TNFSF4, KERA, AIMP1, CD69

Publications for Keratitis

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Sources:
50PubMed
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Articles related to Keratitis:

(show top 50)    (show all 1894)
idTitleAuthorsYear
1
Recurrent non-tuberculous mycobacterial keratitis after deep anterior lamellar keratoplasty for keratoconus. (24136909)
2013
2
The antimicrobial agent C31G is effective for therapy for HSV-1 ocular keratitis in the rabbit eye model. (23860013)
2013
3
Dental Treatments under the General Anesthesia in a Child with Keratitis, Ichthyosis, and Deafness Syndrome. (24151560)
2013
4
Rapid and sensitive diagnosis of Acanthamoeba keratitis by loop-mediated isothermal amplification. (23413965)
2013
5
Microsporidial keratitis: Literature review and report of 2 cases in a tertiary eye care center. (23960992)
2012
6
Keratitis-Ichthyosis-Deafness syndrome: A rare congenital disorder. (23130264)
2012
7
Atypical continuous keratitis in a case of rheumatoid arthritis accompanying severe scleritis. (23023405)
2012
8
Hypopyon in patients with fungal keratitis. (22490405)
2012
9
Candida interface keratitis following deep anterior lamellar keratoplasty. (22450560)
2012
10
New approach to diagnosis and treatment of Acanthamoeba keratitis--systematic review of literature. (23461162)
2012
11
Herpetic keratitis after corneal collagen cross-linking with riboflavin and ultraviolet-A for progressive keratoconus. (22139351)
2011
12
Riboflavin and ultraviolet light a therapy as an adjuvant treatment for medically refractive Acanthamoeba keratitis: report of 3 cases. (20884060)
2011
13
Painless Acanthamoeba keratitis in a soft contact lens wearer--case report. (19860131)
2009
14
Herpetic keratitis and keratouveitis after mitomycin-C use in glaucoma filtering surgery: a short case series. (19882558)
2009
15
Rapid diagnosis of Acanthamoeba keratitis. (19939792)
2009
16
The relative value of confocal microscopy and superficial corneal scrapings in the diagnosis of Acanthamoeba keratitis. (18650660)
2008
17
Acanthamoeba keratitis presenting as a plaque. (18812773)
2008
18
Necrotizing scleritis and peripheral ulcerative keratitis in a case of Sweet's syndrome found culture-positive for Mycobacterium tuberculosis. (18782495)
2008
19
Matrix metalloproteinases (MMP-8, MMP-9) and the tissue inhibitors of metalloproteinases (TIMP-1, TIMP-2) in patients with fungal keratitis. (17251814)
2007
20
Acanthamoeba keratitis due to Acanthamoeba genotype T4 in a non-contact-lens wearer in Turkey. (17013653)
2007
21
Rheumatoid arthritis-associated necrotizing scleritis and peripheral ulcerative keratitis treated successfully with infliximab. (17149060)
2006
22
A case report and review of filamentary keratitis. (15682560)
2005
23
Efficacy of topical aciclovir for the treatment of feline herpetic keratitis: results of a prospective clinical trial and data from in vitro investigations. (16127135)
2005
24
Corneal epithelial cells and stromal keratocytes efficently produce CC chemokine-ligand 20 (CCL20) and attract cells expressing its receptor CCR6 in mouse herpetic stromal keratitis. (15287366)
2004
25
Chronic granulomatous disease and peripheral ulcerative keratitis: a rare case of recurrent external ocular disease. (15510722)
2004
26
In vitro transcorneal penetration of metronidazole and its potential use as adjunct therapy in Acanthamoeba keratitis. (15097135)
2004
27
Evaluation of hematoxylin and eosin and special stains for the detection of acanthamoeba keratitis in penetrating keratoplasties. (12967807)
2003
28
Role and regulation of CXC-chemokines in acute experimental keratitis. (12565810)
2003
29
The outcome of corneal grafting in patients with stromal keratitis of herpetic and non-herpetic origin. (12034687)
2002
30
Oral acyclovir for herpes simplex virus eye disease: effect on prevention of epithelial keratitis and stromal keratitis. Herpetic Eye Disease Study Group. (10922194)
2000
31
Hypopyon keratitis in corneal epithelial basement membrane dystrophy. (10692937)
1999
32
Etiology of immune stromal (interstitial) keratitis. (9603383)
1998
33
Acanthamoeba keratitis: masquerading as adenoviral keratitis. (8977800)
1996
34
Acanthamoeba keratitis: an emerging clinical problem. (8131125)
1994
35
Bilateral Acanthamoeba keratitis and gas-permeable contact lenses. (8238234)
1993
36
Obstinate cases of stromal keratitis treated by combined traditional Chinese and Western medicine. (1453751)
1992
37
Acanthamoeba keratitis. (1710209)
1991
38
Expression of MHC class II antigens and immunoglobulin M by the corneal epithelial cells in herpetic keratitis. (2142484)
1990
39
Radial intrastromal lines in Acanthamoeba keratitis. Case report. (3390046)
1988
40
Acanthamoeba keratitis--the quest for a better prognosis. (3076155)
1988
41
Secondary bacterial keratitis in herpes zoster ophthalmicus. (3121255)
1987
42
Unilateral inferior altitudinal hemianopsia, Argyll Robertson pupil and dendritic keratitis in a young patient with herpes zoster. (6975913)
1981
43
Experimental herpetic keratitis in the guinea pig. (982269)
1976
44
Role of penetrating grafts in herpetic keratitis. (4931401)
1971
45
Interstitial keratitis associated with hidradenitis suppurativa. (4164818)
1967
46
The value of tissue culture vaccine in the prophylaxis of recurrent attacks of herpetic keratitis. (13878161)
1962
47
Reversible chronic recurrent keratitis with vascularization due to ariboflavinosis. (14381853)
1955
48
Nonsyphilitic interstitial keratitis and bilateral deafness (Cogan's syndrome) associated with essential polyangitis (periarteritis nodosa); a review of the syndrome with consideration of a possible pathogenic mechanism. (13046665)
1953
49
Bilateral uveitis and keratitis accompanying periarteritis nodosa. (14866960)
1951
50
Eczematous keratitis and ariboflavinosis. (18103821)
1948

Genetic Variations for Keratitis

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Expression for genes affiliated with Keratitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratitis

Search GEO for disease gene expression data for Keratitis.

Pathways for genes affiliated with Keratitis

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Sources:
51QIAGEN, 29KEGG, 53Reactome, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Keratitis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6CCR6, IL17RA, IL17A, CXCL9, CXCL2, CXCL1
2
Hide members
10.6TNFSF4, CCL20, CCR6, CXCL1, CXCL2, CXCL9
3
Hide members
10.5CCR6, CCL20, TLR9, TNFSF4, CXCL1, CXCL2
4
Hide members
10.5CXCL2, CCR6, CCL20, CXCL9, TNFSF4, CXCL1
5
Hide members
10.5CXCL9, CXCL1, DARC, CCL20, CCR6, CXCL2
6
Hide members
10.5IL17RA, TLR9, IL17A
7
Hide members
10.5CCR6, CXCL1, CXCL2, CXCL9, CCL20
8
Hide members
10.5CCR6, CXCL9, CXCL2, CXCL1, CCL20
910.5CCL20, CXCL1, CXCL2, CXCL9, CCR6
10
Cytokine production by Th17 cells in CF (Mouse model)
10.5CXCL1, IL17RA, IL17A
1110.5IL17A, CXCL1, CCL20
1210.5CCL20, CXCL1, CXCL2

Compounds for genes affiliated with Keratitis

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Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Keratitis according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1rantes4410.9CCR6, CCL20, DEFB4A, CXCL1, CXCL2, IL17RA
2endotoxin4410.9IL17A, CCL20, TLR9, DEFB4A, CXCL1, CXCL9
3vegf4410.9IL17A, CXCL9, CXCL2, CXCL1, CCL20, TKT
4ccl444 2811.9CCL20, CXCL2, CXCL9, IL17A, CCR6
5tarc4410.9CCL20, CXCL1, CXCL2, CXCL9, CCR6
6lipid4410.9DARC, IL17A, GJB2, CD69, DEFB4A, LCN1
7ccl344 2811.9TLR9, CCL20, CXCL9, CXCL2, CXCL1
8calcium44 49 11 2413.9TKT, LCN1, DEFB4A, CCL20, CD69, CXCL1
9nitric oxide44 11 2412.9CD69, TLR9, CXCL1, CXCL2, CXCL9, IL17A
10groalpha4410.9IL17A, CXCL2, CXCL1, CXCL9
11dexamethasone44 49 28 1113.8CXCL1, CXCL2, CXCL9, CCL20, DEFB4A
12tyrosine4410.8TKT, DARC, IL17A, CXCL9, CXCL2, CXCL1
13flagellin44 2811.8CCL20, TLR9, DEFB4A
14pd 98,0594410.8DEFB4A, CD69, CXCL1, CXCL2, IL17A
15mip-3alpha4410.8CCL20, CCR6
16poly(i-c)4410.7CD69, TLR9, CCL20
17peptidoglycan44 2811.7TLR9, CCL20, DEFB4A
18methotrexate44 49 1112.7CD69, CXCL1, IL17A, TKT
19creatinine4410.7CD69, TKT, IL17A, CXCL9, LCN1
20grogamma4410.6CXCL1, CXCL2
21sb 20358044 5911.6IL17A, DEFB4A, CXCL1, CXCL2
22larc4410.5CCL20, CCR6
23grobeta4410.5CXCL1, CXCL2
24sp 60012544 5911.4DEFB4A, IL17A, CXCL2
25oligonucleotide4410.2CXCL2, TLR9, CCL20, IL17A, CXCL1

GO Terms for genes affiliated with Keratitis

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Sources:
16Gene Ontology
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Cellular components related to Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6LCN1, CCL20, TLR9, KERA, DEFB4A, CXCL1
2extracellular spaceGO:00561510.3CCL20, TNFSF4, AIMP1, CXCL1, CXCL2, CXCL9

Biological processes related to Keratitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.8DEFB4A, CCR6, CCL20, AIMP1, CXCL1, CXCL2
2inflammatory responseGO:00695410.8TLR9, CCL20, AIMP1, CXCL1, CXCL9, IL17A
3immune responseGO:00695510.8CXCL2, DEFB4A, CXCL1, CCR6, CXCL9, IL17A
4cell-cell signalingGO:00726710.7CXCL9, AIMP1, CCL20, IL17A, GJB2
5fibroblast activationGO:07253710.7IL17RA, IL17A
6positive regulation of interleukin-23 productionGO:03274710.7IL17A, IL17RA
7positive regulation of cytokine production involved in inflammatory responseGO:190001710.6IL17A, IL17RA
8response to molecule of bacterial originGO:00223710.6CXCL2, TLR9
9cornea development in camera-type eyeGO:06130310.5KERA, PAX6
10positive regulation of interleukin-10 productionGO:03273310.5TLR9, TNFSF4
11signal transductionGO:00716510.4AIMP1, CXCL9, CXCL1, TNFSF4, CCR6, CCL20
12defense response to bacteriumGO:04274210.2DEFB4A, TLR9, CCL20

Molecular functions related to Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.5CCL20, CXCL1, CXCL2, CXCL9
2chemokine receptor activityGO:00495010.5CCR6, DARC
3cytokine activityGO:00512510.4TNFSF4, AIMP1, CXCL9, IL17A
4transmembrane signaling receptor activityGO:00488810.2TLR9, CD69, DARC

Products for genes affiliated with Keratitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Keratitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet