KERH
MCID: KRT004
MIFTS: 71

Keratitis (KERH) malady

Categories: Genetic diseases, Rare diseases, Eye diseases

Aliases & Classifications for Keratitis

Aliases & Descriptions for Keratitis:

Name: Keratitis 54 12 29 13 52 42 14 69
Keratitis, Hereditary 54 50 69
Autosomal Dominant Keratitis 56 66
Keratitis Hereditary 66 29
Dominantly Inherited Keratitis 50
Hereditary Keratitis 56
Kerh 66

Characteristics:

Orphanet epidemiological data:

56
autosomal dominant keratitis
Inheritance: Autosomal dominant; Age of onset: Childhood; Age of death: normal life expectancy;

HPO:

32
keratitis:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 56  
Rare eye diseases


External Ids:

OMIM 54 148190
Disease Ontology 12 DOID:4677
ICD10 33 H16 H16.9
ICD9CM 35 370 370.9
MeSH 42 D007634
NCIt 47 C26805
Orphanet 56 ORPHA2334
ICD10 via Orphanet 34 H16.8
MESH via Orphanet 43 C537022
UMLS via Orphanet 70 C1835698
MedGen 40 C1835698
UMLS 69 C0022568

Summaries for Keratitis

OMIM : 54 Keratitis is a rare ocular disorder presenting with congenital and progressive features predominantly involving the... (148190) more...

MalaCards based summary : Keratitis, also known as keratitis, hereditary, is related to keratomalacia and uveitis, and has symptoms including opacification of the corneal stroma and visual disturbance. An important gene associated with Keratitis is PAX6 (Paired Box 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Zinc and Cyclosporine have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and lung, and related phenotypes are homeostasis/metabolism and immune system

Disease Ontology : 12 A corneal disease that is characterized by inflammation of the cornea.

CDC : 3 Acanthamoeba is a microscopic, free-living ameba, or amoeba* (single-celled living organism), that can cause rare, but severe infections of the eye, skin, and central nervous system. The ameba is found worldwide in the environment in water and soil. The ameba can be spread to the eyes through contact lens use, cuts, or skin wounds or by being inhaled into the lungs. Most people will be exposed to Acanthamoeba during their lifetime, but very few will become sick from this exposure. The three diseases caused by Acanthamoeba are:

UniProtKB/Swiss-Prot : 66 Keratitis hereditary: An ocular disorder characterized by corneal opacification, recurrent stromal keratitis and vascularization.

Wikipedia : 71 Keratitis is a condition in which the eye\'s cornea, the front part of the eye, becomes inflamed. The... more...

Related Diseases for Keratitis

Diseases related to Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 497)
id Related Disease Score Top Affiliating Genes
1 keratomalacia 31.5 CXCL8 IL10 IL1B IL6 TLR2 TLR4
2 uveitis 30.4 CCL2 ICAM1 TNF
3 keratoconus 29.9 IL17A IL1B IL6 TNF
4 tuberculosis 29.6 CCL2 IL10 IL17A IL1B IL6 TNF
5 cutaneous candidiasis 29.5 CCL2 CXCL8 ICAM1
6 hepatitis 29.5 CLEC7A IL10 IL6 TNF
7 band keratopathy 29.5 IL10 IL1B IL6 TLR4 TNF
8 measles 29.5 IL1B IL6 TNF
9 neuropathy 29.4 CXCL8 IL1B IL6 TLR4 TNF
10 pyoderma gangrenosum 29.3 CXCL8 IL1B IL6 TNF
11 exophthalmos 29.1 CXCL8 IL10 IL1B IL6 TNF
12 burns 29.1 CXCL8 IL10 IL17A IL6 MMP9 TNF
13 choroiditis 28.9 CCL2 CXCL8 IL10 IL1B IL6 TLR4
14 rheumatoid arthritis 28.6 CCL2 CXCL1 CXCL8 ICAM1 IL10 IL17A
15 keratitis-ichthyosis-deafness syndrome 12.2
16 herpes simplex virus keratitis 12.2
17 acanthamoeba keratitis 12.2
18 interstitial keratitis 12.2
19 stromal keratitis 12.0
20 deep keratitis 12.0
21 superficial keratitis 11.9
22 filamentary keratitis 11.9
23 exposure keratitis 11.9
24 sclerosing keratitis 11.9
25 gonococcal keratitis 11.8
26 diffuse interstitial keratitis 11.8
27 macular keratitis 11.8
28 kid syndrome 11.8
29 idiopathic linear interstitial keratitis 11.8
30 vernal keratitis 11.8
31 infectious epithelial keratitis 11.8
32 neurotrophic keratopathy 11.6
33 cogan syndrome 11.5
34 corneal ulcer 11.3
35 keratoconjunctivitis sicca 11.1
36 punctate epithelial keratoconjunctivitis 11.0
37 tyrosinemia, type ii 10.9
38 hystrix-like ichthyosis with deafness 10.7
39 acute hemorrhagic conjunctivitis 10.7
40 philophthalmiasis 10.7
41 late congenital syphilis 10.7
42 phaeohyphomycosis 10.7
43 corneal dystrophy, posterior polymorphous, 1 10.7
44 keratosis follicularis spinulosa decalvans 10.7
45 hypersensitivity syndrome, carbamazepine-induced 10.7
46 photokeratitis 10.7
47 ichthyosiform erythroderma, corneal involvement, deafness 10.7
48 dermatoosteolysis, kirghizian type 10.7
49 keratoconjunctivitis 10.6
50 herpes simplex 10.5

Graphical network of the top 20 diseases related to Keratitis:



Diseases related to Keratitis

Symptoms & Phenotypes for Keratitis

Symptoms by clinical synopsis from OMIM:

148190

Clinical features from OMIM:

148190

Human phenotypes related to Keratitis:

32
id Description HPO Frequency HPO Source Accession
1 opacification of the corneal stroma 32 HP:0007759
2 keratitis 32 HP:0000491

UMLS symptoms related to Keratitis:


visual disturbance

MGI Mouse Phenotypes related to Keratitis:

44 (show all 14)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.35 ACKR1 CLEC7A FGF2 GJB2 ICAM1 IL10
2 immune system MP:0005387 10.33 CLEC7A GJB2 ICAM1 IL10 IL17A IL1B
3 cardiovascular system MP:0005385 10.31 FGF2 GJB2 ICAM1 IL10 IL1B IL6
4 hematopoietic system MP:0005397 10.27 MMP9 TLR2 TLR4 TNF CLEC7A FGF2
5 cellular MP:0005384 10.26 FGF2 GJB2 ICAM1 IL10 IL6 JDP2
6 mortality/aging MP:0010768 10.22 IL1B IL6 MMP9 PAX6 TLR2 TLR4
7 digestive/alimentary MP:0005381 10.21 CLEC7A ICAM1 IL10 IL17A IL6 MMP9
8 integument MP:0010771 10.17 GJB2 ICAM1 IL10 IL1B IL6 JDP2
9 muscle MP:0005369 10.02 TNF FGF2 ICAM1 IL10 IL6 MMP9
10 neoplasm MP:0002006 10.02 IL1B IL6 MMP9 PAX6 TLR2 TLR4
11 nervous system MP:0003631 10 FGF2 GJB2 ICAM1 IL10 IL1B IL6
12 respiratory system MP:0005388 9.81 CLEC7A IL10 IL17A IL6 MMP9 PAX6
13 skeleton MP:0005390 9.77 ACKR1 FGF2 GJB2 IL10 IL17A IL1B
14 vision/eye MP:0005391 9.28 FGF2 GJB2 ICAM1 IL10 IL6 MMP9

Drugs & Therapeutics for Keratitis

Drugs for Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 333)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved Phase 4,Phase 2 7440-66-6 32051 23994
2
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
3
Ganciclovir Approved, Investigational Phase 4,Phase 2 82410-32-0 3454
4
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 2 9004-61-9 53477741 24759
5
Glycerol Approved, Experimental Phase 4,Phase 2,Phase 3 56-81-5 753
6
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 299-42-3 9294
7
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
8
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
9
Moxifloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 354812-41-2, 151096-09-2 152946
10
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 90-82-4 7028
11
Loteprednol Approved Phase 4,Phase 3,Phase 2 82034-46-6, 129260-79-3 444025 9865442
12
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
13
Natamycin Approved Phase 4,Phase 3,Phase 1,Phase 2 7681-93-8 5281099
14
Ethanol Approved Phase 4 64-17-5 702
15
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
16
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492
17
Histamine Approved, Investigational Phase 4,Phase 3 75614-87-8, 51-45-6 774
18
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 53477736 447043
19
Tobramycin Approved, Investigational Phase 4,Phase 3 32986-56-4 5496 36294
20
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
21
Isotretinoin Approved Phase 4 4759-48-2 5538 5282379
22
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
23
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
24
Menthol Approved Phase 4,Phase 3 2216-51-5 16666
25
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
26
Dipivefrin Approved Phase 4 52365-63-6 3105
27
Povidone-iodine Approved Phase 4,Phase 3,Phase 2 25655-41-8
28
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
29
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 11103-57-4, 68-26-8 445354
30
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 83-88-5 493570
31
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
32
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
33
Tretinoin Approved, Investigational, Nutraceutical Phase 4 302-79-4 5538
34
Bromfenac Approved July 1997 Phase 4,Phase 3,Phase 2 91714-94-2 60726
35 vitamin d Phase 4
36 Acyclovir Phase 4,Phase 3
37 Prednisolone acetate Phase 4,Phase 3
38 Chelating Agents Phase 4,Phase 3,Phase 2,Phase 1
39 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2
40 Nasal Decongestants Phase 4,Phase 3,Phase 2,Phase 1
41 Ganciclovir triphosphate Phase 4,Phase 2
42 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Neuroprotective Agents Phase 4,Phase 3
44 Neurotransmitter Agents Phase 4,Phase 3,Phase 1
45 Tetrahydrozoline Phase 4,Phase 3,Phase 2,Phase 1
46 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
47 Tocopherols Phase 4
48 Tocotrienols Phase 4
49 Norgestimate, ethinyl estradiol drug combination Phase 4,Phase 3,Phase 2
50 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 520)
id Name Status NCT ID Phase
1 A Placebo Controlled Comparison of Topical Zirgan Versus Genteal Gel for the Treatment of Adenovirus Conjunctivitis Unknown status NCT01533480 Phase 4
2 Oral Nutrition Impact on Tear Film Unknown status NCT01561040 Phase 4
3 Efficacy of FreshKote and Systane for the Treatment of Dry Eye and Improvement of Osmolarity Unknown status NCT01386073 Phase 4
4 Altaire Gel Forming Solution Versus Refresh Tears for the Treatment of Dry Eye Signs and Symptoms Unknown status NCT01382810 Phase 4
5 Comparison of Efficacy, Safety and Anti-Inflammatory Effect Between Topical 0.05%Cyclosporine A Emulsion and REFRESH® in Patients With Moderate to Severe Dry Eyes Unknown status NCT00704275 Phase 4
6 Topical Cyclosporine for the Treatment of Dry Eye in Patients Infected With the Human Immunodeficiency Virus Unknown status NCT00797030 Phase 4
7 A Placebo Controlled Double Masked Clinical Assessment Study of Essential Fatty Acid Supplement and Its Effect on Patients With Apparent Aqueous Deficient Dry Eye Syndrome Unknown status NCT00344721 Phase 4
8 Study of the Presence and Extent of Corneal Disturbance Associated With B+L Biotrue MPS Used With B+L PureVision Lenses Completed NCT01268306 Phase 4
9 The Effects of BAK on the Blood Aqueous Barrier of Pseudophakic Patients Completed NCT01280110 Phase 4
10 Steroids for Corneal Ulcers Trial Completed NCT00324168 Phase 4
11 Evaluation of Tear Osmolarity Over Time With Sustained Use of Thera Tears Lubricating Drops Completed NCT02758327 Phase 4
12 Zylet vs TobraDex in Blepharokeratoconjunctivitis Completed NCT00447577 Phase 4
13 Multicenter, Randomized, Controlled Study of the Effect of Lotemax on Initiation of Dry Eye Treatment With Restasis Completed NCT00407043 Phase 4
14 The Utility of in Vivo Confocal Microscopy to Assess Cellular Response and Efficacy of Long-term Topical Steroid Treatment in Patients With Dry Eye Disease Completed NCT02120079 Phase 4
15 A Safety and Efficacy Study of OPTIVE FUSION™ With VISMED® Multi for the Management of Dry Eye Completed NCT02117687 Phase 4
16 A Four Week Study of Azithromycin Ophthalmic Solution, 1% Versus Placebo in Subjects With Dry Eye Disease Completed NCT01014078 Phase 4
17 Safety and Efficacy of Carboxymethylcellulose for Ocular Surface Integrity in Symptomatic Dry Eye Completed NCT00987727 Phase 4
18 Objective Measurements of Prolonged Effects of Restasis on Dry Eye Disease Completed NCT00567177 Phase 4
19 Bromfenac 0.09% vs Ketorolac 0.4% for Cyclosporine Induction Phase Completed NCT00520260 Phase 4
20 A Phase 4 Study Investigating the Efficacy of Retaine™ in Managing Signs and Symptoms Associated With Dry Eye Syndrome Completed NCT02139033 Phase 4
21 Treatment of Epidemic Keratoconjunctivitis With 2% Povidone-iodine Completed NCT01179412 Phase 4
22 Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda Completed NCT01211327 Phase 4
23 Study of the Clinical and Biological Efficacity of NAAXIA SINE® in Vernal Keratoconjunctivitis Completed NCT00357019 Phase 4
24 Comparative Study of Rohto Dry-Aid® and Systane® Ultra in Patients With Dry Eye Completed NCT03183089 Phase 4
25 Symptom Response in Normal and Dry Eye Patients Secondary to Application of a Menthol-Containing Eyedrop (Rohto® Hydra) Completed NCT02985827 Phase 4
26 A Study of the Effect of Zinc-Hyaluronate on Ocular Surface Sensations in Patients With Dry Eye Completed NCT02951910 Phase 4
27 Comparison of Autologous Serum Versus Preservative Free Artificial Tear Completed NCT02752763 Phase 4
28 A Study to Determine the Relief of Dry Eye Symptoms With the Use of TheraTears® Products (DUNLIN) Completed NCT02014922 Phase 4
29 Safety and Efficacy of Punctal Plug Insertion in Patients With Dry Eye Completed NCT01684436 Phase 4
30 Efficacy Study of a New Eyedrop on Silicone Hydrogel Contact Lens Wearers With Dry Eye Complaints Completed NCT01543061 Phase 4
31 Evaluation of the Effect and Tolerance of Preservative Free NAAGA on the Inflammatory Component and Symptoms of Dry Eye Syndrome in Allergic Conjunctivitis Patients Completed NCT01203540 Phase 4
32 TearLab Refractive Surgery Dry Eye Study Completed NCT01176045 Phase 4
33 Efficacy of Systane Ultra in Post Menopausal Women With Dry Eye Completed NCT01105910 Phase 4
34 A Four Week Study of Azithromycin Ophthalmic Solution, 1% Versus Rewetting Drops in Subjects With History and Current Complaint of Contact Lens-Related Dry Eye (CLDE) Completed NCT01105624 Phase 4
35 Efficacy of Systane Balance to Stabilize the Tear Film in Dry Eye Subjects Completed NCT01086774 Phase 4
36 A Clinical Evaluation Pilot Study of the Efficacy of Blink® Tears Lubricant Eye Drops for the Relief of Dry Eye Symptoms Following Implantation of Tecnis® Multifocal Introcular Lens Completed NCT01061268 Phase 4
37 Study to Compare the Efficacy and Safety of Two Non-Preserved Artificial Tears for the Treatment of Dry Eye Signs and Symptoms Completed NCT00938704 Phase 4
38 Kynex Versus Refresh Plus Study in Subject With Dry Eye Completed NCT00809198 Phase 4
39 A Prospective, Randomized, Double-Masked, Single Center, Clinical Comparison of the Use of Systane Ultra in the Management of Dry Eyes in Bilateral Eyes Completed NCT00781092 Phase 4
40 Performance and Acceptance of Optive Versus Hylocomod Eyedrops in Patients With Dry Eye Symptoms Completed NCT00761202 Phase 4
41 Evaluate Artificial Tear Efficacy in Moderate to Severe Dry Eye Completed NCT00724412 Phase 4
42 Bilateral, Masked Comparison of PEG-400 Based Artificial Tear and Systane for the Treatment of Dry Eye Signs, Symptoms and Visual Quality Completed NCT00622037 Phase 4
43 Bilateral, Masked Comparison of PEG-400 Based Artificial Tear vs. Systane for Dry Eye Signs, Symptoms & Refractive Regression Associated With Myopic Laser in Situ Keratomilieusis (LASIK). Completed NCT00620893 Phase 4
44 Safety and Efficacy of Optive in Contact Lens Wearers With Dry Eyes Completed NCT00469573 Phase 4
45 Efficacy and Safety of a New Multi-dose Lubricant Eye Drop Concomitant With Restasis® (Cyclosporine A) for the Treatment of Dry Eye Symptoms Completed NCT00405457 Phase 4
46 A Comparison of Optive in Patients Previously Using Systane for the Treatment of Dry Eye Completed NCT00399230 Phase 4
47 Efficacy of Optive Versus Systane Concomitant With Restasis (Cyclosporine A) for the Treatment of Dry Eye Symptoms Completed NCT00399061 Phase 4
48 Comparison of Systane Free vs. Saline in the Treatment of Dry Eye Completed NCT00388791 Phase 4
49 Comparative Study of 0.5% Carboxymethylcellulose With 0.005% Stabilized Oxychlorocomplex (PURITE™) Versus 0.5% Carboxymethylcellulose in the Treatment of Dry Eye Completed NCT00386646 Phase 4
50 Efficacy of Cyclosporine for the Prevention and Treatment of Dry Eye Symptoms Following LASIK or Photorefractive Keratectomy Completed NCT00349440 Phase 4

Search NIH Clinical Center for Keratitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: keratitis

Genetic Tests for Keratitis

Genetic tests related to Keratitis:

id Genetic test Affiliating Genes
1 Keratitis, Hereditary 29
2 Keratitis 29

Anatomical Context for Keratitis

MalaCards organs/tissues related to Keratitis:

39
Eye, Skin, Lung, T Cells, Endothelial, Testes, Neutrophil

Publications for Keratitis

Articles related to Keratitis:

(show top 50) (show all 2161)
id Title Authors Year
1
The role of Mincle in innate immune to fungal keratitis. ( 28141595 )
2017
2
AmpliVue Is a Practical and Timely Test for the Detection of HSV From Keratitis Specimens. ( 28520594 )
2017
3
A dot hybridization assay for the diagnosis of bacterial keratitis. ( 28484310 )
2017
4
Long-term Outcomes of Pediatric Penetrating Keratoplasty for Herpes Simplex Virus Keratitis. ( 27746299 )
2017
5
Keratitis by a rare pathogen Colletotrichum gloeosporioides: A case report. ( 28501467 )
2017
6
Keratitis due to microfilariae in dogs: a newly recognized disease. ( 28508467 )
2017
7
Short Synthetic I+-Helical-Forming Peptide Amphiphiles for Fungal Keratitis Treatment In Vivo. ( 28081296 )
2017
8
The cif Virulence Factor Gene Is Present in Isolates From Patients With Pseudomonas aeruginosa Keratitis. ( 28079684 )
2017
9
A case of bilateral keratitis caused by Providencia alcalifaciens: a rarely encountered ocular pathogen. ( 28516225 )
2017
10
Methods for In Vitro Analysis of Antimicrobial Activity and Toxicity of Anti-keratitis Peptides: Bacterial Viability in Tears, MTT, and TNF-I+ Release Assays. ( 28013521 )
2017
11
Fungal keratitis in the Republic of Ireland. ( 28524886 )
2017
12
Understanding the Role of Chemokines and Cytokines in Experimental Models of Herpes Simplex Keratitis. ( 28491875 )
2017
13
Infectious keratitis and orthokeratology lens use: a systematic review. ( 28534320 )
2017
14
Infectious keratitis after laser vision correction: Incidence and risk factors. ( 28532931 )
2017
15
Infectious keratitis in a patient with kid syndrome. ( 28461083 )
2017
16
Commentary on Chlorhexidine Keratitis. ( 28009679 )
2017
17
Free-Living Amoebae Keratitis. ( 28486311 )
2017
18
Twelve-year analysis of microbial keratitis trends at a UK tertiary hospital. ( 28452995 )
2017
19
Investigation of corneal autoantibodies in horses with immune mediated keratitis (IMMK). ( 28494929 )
2017
20
Tear Cytokine Levels in Contact Lens Wearers With Acanthamoeba Keratitis. ( 28489721 )
2017
21
Fungal Keratitis Associated With Airborne Organic Debris and Soft Contacts Lenses: Case Reports and Review of the Literature. ( 28520596 )
2017
22
Mitogenic lectins from Cephalosporium curvulum (CSL) and Aspergillus oryzae (AOL) mediate host-pathogen interactions leading to mycotic keratitis. ( 28470344 )
2017
23
In vivo confocal microscopy appearance of Fusarium and Aspergillus species in fungal keratitis. ( 28043985 )
2017
24
Rapid corneal thinning and perforated ulcerative keratitis in a patient with relapsing polychondritis. ( 28331873 )
2017
25
Methods for In Vivo/Ex Vivo Analysis of Antimicrobial Peptides in Bacterial Keratitis: siRNA Knockdown, Colony Counts, Myeloperoxidase, Immunostaining, and RT-PCR Assays. ( 28013522 )
2017
26
Coexistence of herpes simplex virus infection in microsporidial stromal keratitis associated with granulomatous inflammation. ( 28513490 )
2017
27
Long-term outcomes of the Boston type I keratoprosthesis in eyes with previous herpes simplex virus keratitis. ( 28495905 )
2017
28
Herpes Simplex Virus Keratitis and Resistance to Acyclovir. ( 28060081 )
2017
29
Bilateral Herpetic Keratitis After Bilateral Intravitreal Bevacizumab for Exudative Macular Degeneration. ( 28489722 )
2017
30
Number of Bacteria and Time of Coincubation With Bacteria Required for the Development of Acanthamoeba Keratitis. ( 28079686 )
2017
31
Peripheral ulcerative keratitis associated with chronic malabsorption syndrome and miliary tuberculosis in a child. ( 27433045 )
2016
32
Recessive Mutation in a Nuclear-Encoded Mitochondrial tRNA Synthetase Associated With Infantile Cataract, Congenital Neurotrophic Keratitis, and Orbital Myopathy. ( 27078007 )
2016
33
Acanthamoeba keratitis challenges a case report. ( 27220232 )
2016
34
Scedosporium Keratitis: An Experience From a Tertiary Eye Hospital in South India. ( 27538191 )
2016
35
Acute Corneal Hydrops Complicated by Microbial Keratitis: Case Series Reveals Poor Immediate and Long-Term Prognosis. ( 27191669 )
2016
36
Inheritance of chronic superficial keratitis in Australian Greyhounds. ( 27147552 )
2016
37
Hemorrhagic Descemet Membrane Detachment Following Syphilitic Interstitial Keratitis. ( 27227396 )
2016
38
Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents. ( 27273328 )
2016
39
Herpetiform keratitis and palmoplantar hyperkeratosis: warning signs for Richner-Hanhart syndrome. ( 27832414 )
2016
40
Incidence of chloramphenicol use and the effect on corneal scrape results in bacterial keratitis. ( 27549348 )
2016
41
Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents - comment. ( 27620850 )
2016
42
The pathogenic spectrum of fungal keratitis in northwestern China. ( 28003991 )
2016
43
Investigation of the clinical features in filamentary keratitis in Hangzhou, east of China. ( 27583881 )
2016
44
Identification of pathogenic factors potentially involved in Staphylococcus aureus keratitis using proteomics. ( 27590660 )
2016
45
Loss of Neurokinin-1 Receptor Alters Ocular Surface Homeostasis and Promotes an Early Development of Herpes Stromal Keratitis. ( 27798158 )
2016
46
Novel Phagocytosis-Resistant Extended-Spectrum I^-Lactamase-Producing Escherichia coli From Keratitis. ( 27631542 )
2016
47
Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis: An observational study. ( 27684823 )
2016
48
Specificity of in vivo confocal cornea microscopy in Acanthamoeba keratitis. ( 27312210 )
2016
49
Tripartite Motif 8 (TRIM8) Positively Regulates Pro-inflammatory Responses in Pseudomonas aeruginosa-Induced Keratitis Through Promoting K63-Linked Polyubiquitination of TAK1 Protein. ( 27995356 )
2016
50
Development of Herpes Simplex Virus Infectious Epithelial Keratitis During Oral Acyclovir Therapy and Response to Topical Antivirals. ( 26989961 )
2016

Variations for Keratitis

ClinVar genetic disease variations for Keratitis:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 PAX6 NM_000280.4(PAX6): c.917-2A> T single nucleotide variant Pathogenic rs587776571 GRCh38 Chromosome 11, 31793555: 31793555

Expression for Keratitis

Search GEO for disease gene expression data for Keratitis.

Pathways for Keratitis

Pathways related to Keratitis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.15 CCL2 CLEC7A CXCL1 CXCL2 CXCL8 FGF2
2
Show member pathways
13.94 CCL2 CXCL1 CXCL2 CXCL8 FGF2 IL10
3
Show member pathways
13.76 CCL2 CXCL1 CXCL2 CXCL8 IL10 IL17A
4
Show member pathways
13.62 CCL2 CXCL8 FGF2 ICAM1 IL10 IL17A
5
Show member pathways
13.55 CCL2 CXCL1 CXCL2 CXCL8 FGF2 IL10
6
Show member pathways
13.46 CCL2 CXCL1 CXCL2 CXCL8 FGF2 ICAM1
7
Show member pathways
13.43 CCL2 CXCL1 CXCL2 CXCL8 FGF2 IL10
8
Show member pathways
13.12 CCL2 CLEC7A CXCL1 CXCL2 CXCL8 IL1B
9
Show member pathways
13.08 CCL2 CXCL8 IL10 IL1B IL6 MMP9
10
Show member pathways
12.98 CXCL8 ICAM1 IL10 IL17A IL1B IL6
11
Show member pathways
12.95 CCL2 CXCL8 ICAM1 IL1B IL6 TLR2
12
Show member pathways
12.81 FGF2 IL1B IL6 TLR2 TLR4 TNF
13
Show member pathways
12.77 CCL2 CXCL1 FGF2 IL10 IL17A IL1B
14
Show member pathways
12.75 IL10 IL17A IL1B IL6 TLR2 TLR4
15 12.67 CCL2 IL10 IL17A IL1B TLR2 TNF
16
Show member pathways
12.53 IL10 IL17A IL1B IL6 TNF
17
Show member pathways
12.46 CCL2 CXCL1 CXCL2 CXCL8 IL17A IL1B
18
Show member pathways
12.45 CCL2 ICAM1 IL1B IL6 TNF
19 12.42 FGF2 MMP9 TLR2 TLR4 TNF
20
Show member pathways
12.4 CXCL8 IL1B IL6 TLR4 TNF
21 12.4 CLEC7A IL10 IL1B IL6 TLR2 TLR4
22
Show member pathways
12.38 CXCL8 IL6 TLR2 TLR4 TNF
23
Show member pathways
12.37 IL10 IL1B TLR2 TLR4 TNF
24
Show member pathways
12.36 CXCL8 IL1B IL6 TLR2 TLR4 TNF
25
Show member pathways
12.34 CXCL8 IL10 IL17A IL1B IL6 TNF
26 12.32 IL6 MMP9 TLR2 TLR4 TNF
27 12.31 CXCL8 IL10 IL1B IL6 TNF
28 12.23 CCL2 ICAM1 IL1B MMP9 TNF
29
Show member pathways
12.17 ACKR1 CCL2 CXCL1 CXCL2 CXCL8
30 12.16 CCL2 ICAM1 TLR2 TLR4
31 12.13 CCL2 CXCL1 CXCL2 ICAM1 IL1B IL6
32 12.11 CCL2 CXCL8 ICAM1 IL1B IL6 TNF
33
Show member pathways
12.11 IL10 IL17A IL1B IL6 TLR2 TLR4
34
Show member pathways
12.09 IL17A IL1B IL6 TLR2 TLR4
35 12.08 CXCL2 CXCL8 ICAM1 IL1B TLR4 TNF
36 12.08 CCL2 CXCL8 FGF2 ICAM1 IL10 IL17A
37
Show member pathways
12.06 CXCL1 CXCL8 ICAM1 IL17A IL6 TLR4
38 12.05 CXCL1 CXCL8 IL1B IL6
39 12.04 CXCL1 CXCL8 IL10 IL1B IL6 TLR2
40 12 CXCL1 CXCL2 CXCL8 IL1B IL6 TLR4
41 11.93 CXCL8 IL10 IL1B IL6 TLR4 TNF
42 11.92 IL10 IL17A IL1B TNF
43 11.89 IL10 IL1B IL6 TNF
44 11.88 ICAM1 IL10 IL6 TLR2 TLR4 TNF
45
Show member pathways
11.85 CXCL2 CXCL8 ICAM1 IL1B IL6 MMP9
46 11.83 CXCL8 ICAM1 IL6
47 11.81 CCL2 CXCL2 CXCL8 FGF2 IL1B IL6
48 11.81 CCL2 CXCL1 CXCL8 ICAM1 IL17A IL1B
49 11.73 CXCL8 IL6 MMP9
50 11.73 CCL2 CXCL1 CXCL2 CXCL8 ICAM1 IL1B

GO Terms for Keratitis

Cellular components related to Keratitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CCL2 CXCL1 CXCL2 CXCL8 FGF2 IL10
2 external side of plasma membrane GO:0009897 9.55 ICAM1 IL17A IL6 TLR4 TNF
3 extracellular space GO:0005615 9.4 CCL2 CXCL1 CXCL2 CXCL8 FGF2 ICAM1

Biological processes related to Keratitis according to GeneCards Suite gene sharing:

(show top 50) (show all 74)
id Name GO ID Score Top Affiliating Genes
1 defense response GO:0006952 9.98 ACKR1 CXCL1 CXCL2 CXCL8 TNF
2 animal organ morphogenesis GO:0009887 9.96 CCL2 FGF2 PAX6 TNF
3 cellular response to tumor necrosis factor GO:0071356 9.96 CCL2 CXCL8 ICAM1 IL6
4 activation of MAPK activity GO:0000187 9.95 FGF2 IL1B TLR4 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 ICAM1 IL1B IL6 TLR2 TLR4 TNF
6 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.94 IL10 IL1B IL6 TNF
7 response to glucocorticoid GO:0051384 9.93 CCL2 IL10 IL6 TNF
8 response to wounding GO:0009611 9.92 CCL2 IL6 PAX6
9 cellular response to organic cyclic compound GO:0071407 9.92 CCL2 IL1B TNF
10 response to insulin GO:0032868 9.92 ICAM1 IL10 IL6 TLR2
11 cellular response to interleukin-1 GO:0071347 9.92 CCL2 CXCL8 ICAM1 IL17A IL6
12 defense response to Gram-positive bacterium GO:0050830 9.91 IL6 TLR2 TNF
13 positive regulation of endothelial cell proliferation GO:0001938 9.91 CCL2 FGF2 IL10
14 positive regulation of JNK cascade GO:0046330 9.91 IL1B TLR4 TNF
15 chemokine-mediated signaling pathway GO:0070098 9.91 ACKR1 CCL2 CXCL1 CXCL2 CXCL8
16 cell chemotaxis GO:0060326 9.9 CCL2 CXCL1 CXCL2
17 neutrophil chemotaxis GO:0030593 9.9 CCL2 CXCL8 IL1B
18 immune response GO:0006955 9.9 CCL2 CXCL1 CXCL2 CXCL8 IL10 IL17A
19 humoral immune response GO:0006959 9.89 CCL2 IL6 TNF
20 positive regulation of tumor necrosis factor production GO:0032760 9.88 CCL2 TLR2 TLR4
21 positive regulation of interferon-gamma production GO:0032729 9.87 IL1B TLR4 TNF
22 negative regulation of fat cell differentiation GO:0045599 9.87 IL6 JDP2 TNF
23 response to progesterone GO:0032570 9.87 CCL2 GJB2 TLR2
24 cellular response to estradiol stimulus GO:0071392 9.86 CCL2 IL10 IL6
25 response to amino acid GO:0043200 9.86 CCL2 ICAM1 IL6
26 cellular response to dexamethasone stimulus GO:0071549 9.86 CCL2 GJB2 ICAM1 IL6
27 response to bacterium GO:0009617 9.85 CCL2 IL6 TLR4
28 response to antibiotic GO:0046677 9.85 CCL2 GJB2 IL6
29 protein kinase B signaling GO:0043491 9.85 CCL2 IL1B TNF
30 positive regulation of interleukin-8 production GO:0032757 9.84 IL1B TLR2 TLR4 TNF
31 positive regulation of neutrophil chemotaxis GO:0090023 9.82 CXCL1 CXCL2 CXCL8
32 negative regulation of interleukin-6 production GO:0032715 9.81 IL10 TLR4 TNF
33 defense response to protozoan GO:0042832 9.81 CLEC7A IL10 IL6
34 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.8 IL10 MMP9 TNF
35 positive regulation of NF-kappaB import into nucleus GO:0042346 9.8 IL1B TLR2 TLR4 TNF
36 positive regulation of interleukin-6 production GO:0032755 9.8 IL1B IL6 TLR2 TLR4 TNF
37 cellular response to lipopolysaccharide GO:0071222 9.8 CCL2 CXCL8 ICAM1 IL10 IL6 TLR4
38 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.78 CCL2 TLR2 TLR4
39 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.77 IL10 IL1B TNF
40 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 ICAM1 IL1B IL6 TLR4 TNF
41 positive regulation of chemokine production GO:0032722 9.76 IL6 TLR2 TLR4 TNF
42 I-kappaB phosphorylation GO:0007252 9.75 TLR2 TLR4
43 PERK-mediated unfolded protein response GO:0036499 9.75 CCL2 CXCL8
44 cellular response to nutrient levels GO:0031669 9.75 ICAM1 IL6
45 regulation of cytokine secretion GO:0050707 9.74 TLR2 TLR4
46 positive regulation of chemokine biosynthetic process GO:0045080 9.74 IL1B TNF
47 negative regulation of lipid storage GO:0010888 9.73 IL6 TNF
48 cellular response to lipoteichoic acid GO:0071223 9.73 TLR2 TLR4
49 response to molecule of bacterial origin GO:0002237 9.73 CXCL2 CXCL8 IL10 TLR2
50 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.72 TLR4 TNF

Molecular functions related to Keratitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor activity GO:0004872 9.71 ACKR1 ICAM1 TLR2 TLR4
2 growth factor activity GO:0008083 9.56 CXCL1 FGF2 IL10 IL6
3 CXCR chemokine receptor binding GO:0045236 9.37 CXCL1 CXCL2
4 signaling pattern recognition receptor activity GO:0008329 9.32 CLEC7A TLR2
5 cytokine activity GO:0005125 9.32 CCL2 CXCL1 CXCL2 CXCL8 FGF2 IL10
6 chemokine activity GO:0008009 9.26 CCL2 CXCL1 CXCL2 CXCL8
7 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4

Sources for Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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