MCID: KRT004
MIFTS: 62

Keratitis malady

Eye diseases, Rare diseases categories

Summaries for Keratitis

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Sources:
66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Keratitis is a condition in which the eye\'s cornea, the front part of the eye, becomes inflamed. The... more...

MalaCards: Keratitis, also known as autosomal dominant keratitis, is related to eye disease and rheumatoid arthritis. An important gene associated with Keratitis is PAX6 (paired box 6), and among its related pathways are Th17 Differentiation and IL-17 Family Signaling Pathways. The drugs loteprednol etabonate and loteprednol and the compounds ganciclovir and thymidine have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related mouse phenotypes are vision/eye and no phenotypic analysis.

Description from OMIM:48 148190

Aliases & Classifications for Keratitis

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Sources:
9Disease Ontology, 10diseasecard, 48OMIM, 11DISEASES, 46Novoseek, 63UMLS, 50Orphanet, 28ICD9CM, 59SNOMED-CT, 36MeSH, 41NCIt, 37MESH via Orphanet, 27ICD10 via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 50 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

50
autosomal dominant keratitis:
Inheritance: Autosomal dominant; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

keratitis 9 10 48 11 46 63
autosomal dominant keratitis 50
unspecified keratitis 9
keratitis, hereditary 63
hereditary keratitis 50
keratitis nos 9


External Ids:

Disease Ontology9 DOID:4677
ICD9CM28 370.9, 370
MeSH36 D007634
NCIt41 C26805
OMIM48 148190
MESH via Orphanet37 C537022
ICD10 via Orphanet27 H16.8
UMLS via Orphanet64 C1835698
ICD1026 H16, H16.9

Related Diseases for Keratitis

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Keratitis:



Diseases related to keratitis

Symptoms for Keratitis

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Sources:
48OMIM
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Symptoms by clinical synopsis from OMIM:

148190

Clinical features from OMIM:

148190

Drugs & Therapeutics for Keratitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Keratitis

Drug clinical trials:

Search ClinicalTrials for Keratitis

Search NIH Clinical Center for Keratitis

Search CenterWatch for Keratitis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Keratitis

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Anatomical Context for Keratitis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Keratitis:

34
Eye, T cells, Endothelial, Testes, B cells, Skin, Liver, Retina, Lymph node, Thyroid, Brain, Bone, Bone marrow

Animal Models for Keratitis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Keratitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.8TKT, GJB2, PAX6, KERA
2MP:00030128.5GJB2, IL17RA, IL17A, MFF
3MP:00053977.8CCR6, IL17A, IL17RA, KERA, TNFSF4
4MP:00053767.2PAX6, GJB2, IL17RA, IL17A, AIMP1, CCR6
5MP:00053876.8IL17A, PAX6, CCR6, AIMP1, IL17RA, GJB2

Publications for Keratitis

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Sources:
53PubMed
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Articles related to Keratitis:

(show top 50)    (show all 1876)
idTitleAuthorsYear
1
Corneal collagen crosslinking and herpetic keratitis. (23889879)
2013
2
Actinomyces bowdenii ulcerative keratitis in a dog. (23121462)
2013
3
Recurrent non-tuberculous mycobacterial keratitis after deep anterior lamellar keratoplasty for keratoconus. (24136909)
2013
4
Acanthamoeba keratitis: study of the 5-year incidence in Israel. (23878134)
2013
5
Isolation and characterization of a new fungal genus and species, Aphanoascella galapagosensis, from carapace keratitis of a Galapagos tortoise (Chelonoidis nigra microphyes). (22852752)
2013
6
Severe ulcerative keratitis in ocular cowpox infection. (22932773)
2013
7
Herpes Simplex epithelial keratitis associated with daily disposable contact lens wear. (24333040)
2013
8
Inhibition of Ataxia Telangiectasia Mutated (ATM) Kinase Suppresses Herpes Simplex Virus Type 1 (HSV-1) Keratitis. (24370835)
2013
9
An unusual case of peripheral ulcerative keratitis as a presenting feature in an otherwise healthy patient with undiagnosed human immunodeficiency virus infection and low CD4 counts. (23514657)
2013
10
Modulation of immune signaling, bacterial clearance, and corneal integrity by toll-like receptors during streptococcus pneumoniae keratitis. (23841825)
2013
11
Corneal changes in neurosurgically induced neurotrophic keratitis. (24158681)
2013
12
Therapeutic effect of deep anterior lamellar keratoplasty for active or quiescent herpetic stromal keratitis. (22349979)
2012
13
Chronic recalcitrant bacterial infection in steroid modified interstitial (stromal) keratitis: presentation and management. (23252209)
2012
14
A case of nocardia keratitis treated successfully with topical amikacin. (22344016)
2012
15
Bowman's layer encystment in cases of persistent Acanthamoeba keratitis. (22927735)
2012
16
Fungal keratitis caused by Chaetomium atrobrunneum. (22045390)
2012
17
Interstitial keratitis secondary to severe hidradenitis suppurativa responding to adalimumab. (22146546)
2012
18
Medical interventions for fungal keratitis. (22336802)
2012
19
Radial keratoneuritis as a presenting sign in acanthamoeba keratitis. (21887085)
2011
20
Interstitial keratitis secondary to severe hidradenitis suppurativa: a case report and literature review. (20628295)
2010
21
New-onset herpes simplex virus keratitis after cataract surgery. (19092420)
2009
22
Herpetic keratitis after descemet stripping automated endothelial keratoplasty for failed graft. (19125048)
2009
23
A rare connexin 26 mutation in a patient with a forme fruste of keratitis-ichthyosis-deafness (KID) syndrome. (19785089)
2009
24
Fusarium and Acanthamoeba keratitis: can a single centre detect outbreaks? (18441185)
2008
25
The application of in vivo confocal scanning laser microscopy in the management of Acanthamoeba keratitis. (17679934)
2007
26
Good visual outcome after prompt treatment of acanthamoeba keratitis associated with overnight orthokeratology lens wear. (17993830)
2007
27
Impression cytology in the diagnosis of acanthamoeba keratitis with surface involvement. (14962424)
2004
28
Bilateral deep keratitis caused by systemic lupus erythematosus. (15075893)
2004
29
Corneal epithelial cells and stromal keratocytes efficently produce CC chemokine-ligand 20 (CCL20) and attract cells expressing its receptor CCR6 in mouse herpetic stromal keratitis. (15287366)
2004
30
Non-contact lens related Acanthamoeba keratitis at a tertiary eye care center in south India: Implications for eye care programs in the region. (12709670)
2003
31
Recent advances in the treatment of Acanthamoeba keratitis. (12145728)
2002
32
Persistence of acanthamoeba antigen following acanthamoeba keratitis. (11222330)
2001
33
Control of stromal keratitis by inhibition of neovascularization. (11549594)
2001
34
Classification of herpes simplex virus keratitis and anterior uveitis. (10090358)
1999
35
Acanthamoeba keratitis and contact lens wear. (9371196)
1997
36
Should we be using polyhexamethylene biguanide to treat Acanthamoeba keratitis? (9267593)
1997
37
Keratitis, ichthyosis, and deafness (KID syndrome): review of the literature and proposal of a new terminology. (9122065)
1996
38
Chemotherapy for acanthamoeba keratitis. (7891502)
1995
39
Acinetobacter exposure keratitis. (8060938)
1994
40
Murine herpes simplex virus keratitis is accentuated by CD4+, V beta 8.2+ Th2 T cells. (7908153)
1993
41
Acanthamoeba keratitis: experience in a non-specialist microbiology laboratory. (1890209)
1991
42
Filamentary keratitis--the clinical challenges. (1813523)
1991
43
Recurrent herpetic keratitis: failure to detect herpes simplex virus infection using the Syva MicroTrak HSV1/HSV2 direct specimen identification/typing test. (1963928)
1990
44
Immunobiology of Langerhans cells on the ocular surface. II. Role of central corneal Langerhans cells in stromal keratitis following experimental HSV-1 infection in mice. (2561960)
1989
45
Quantitation of purified monoclonal antibody needed to prevent HSV-1 induced stromal keratitis in mice. (2736955)
1989
46
Management of herpetic keratitis. (7046194)
1982
47
HLA antigens in recurrent stromal herpes simplex virus keratitis. (7356786)
1980
48
Management of resistant cases of herpetic keratitis using cryo-immunotherapy technique. (1031073)
1976
49
Some aspects of interstitial keratitis. (15410175)
1950
50
Eczematous keratitis and ariboflavinosis. (18103821)
1948

Variations for Keratitis

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Expression for genes affiliated with Keratitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratitis

Search GEO for disease gene expression data for Keratitis.

Pathways for genes affiliated with Keratitis

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Sources:
51PathCards, 55R&D Systems, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome, 54QIAGEN, 31KEGG
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Compounds for genes affiliated with Keratitis

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Sources:
46Novoseek, 12DrugBank, 25HMDB, 30IUPHAR
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Compounds related to Keratitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ganciclovir46 1210.5TKT, GJB2
2thymidine46 2510.4TKT, GJB2, IL17A
3ccl446 3010.2CCR6, IL17A
4rantes468.8IL17RA, IL17A, CCR6
5vegf468.7TKT, IL17A, CCR6, PAX6

GO Terms for genes affiliated with Keratitis

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17Gene Ontology
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Cellular components related to Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057779.5TKT, MFF

Biological processes related to Keratitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cornea development in camera-type eyeGO:0613039.8PAX6, KERA
2fibroblast activationGO:0725379.7IL17A, IL17RA
3response to woundingGO:0096119.7AIMP1, PAX6
4positive regulation of interleukin-23 productionGO:0327479.7IL17RA, IL17A
5positive regulation of cytokine production involved in inflammatory responseGO:19000179.6IL17RA, IL17A
6cell-cell signalingGO:0072679.2AIMP1, IL17A, GJB2
7immune responseGO:0069558.5CCR6, TNFSF4, IL17A

Molecular functions related to Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL17A, TNFSF4, AIMP1

Products for genes affiliated with Keratitis

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  • Antibodies
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  • Antibodies

Sources for Keratitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet