MCID: KRT004
MIFTS: 56

Keratitis malady

Eye category

Summaries for Keratitis

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Keratitis is a condition in which the eye\'s cornea, the front part of the eye, becomes inflamed. The... more...

MalaCards: Keratitis, also known as autosomal dominant keratitis, is related to uveitis and arthritis. An important gene associated with Keratitis is PAX6 (paired box 6), and among its related pathways are PEDF Induced Signaling and Rho Family GTPases. The drugs loteprednol etabonate and loteprednol and the compounds rantes and endotoxin have been mentioned in the context of this disorder. Related mouse phenotype immune system.

Description from OMIM:47 148190

Aliases & Classifications for Keratitis

Sources:
8Disease Ontology, 9diseasecard, 47OMIM, 10DISEASES, 45Novoseek, 61UMLS, 49Orphanet, 40NCIt, 57SNOMED-CT, 27ICD9CM, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Characteristics (Orphanet epidemiological data):

49
autosomal dominant keratitis:
Inheritance: Autosomal dominant; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

keratitis 8 9 47 10 45 61
autosomal dominant keratitis 49
unspecified keratitis 8
keratitis, hereditary 61
hereditary keratitis 49
keratitis nos 8


External Ids:

Disease Ontology8 DOID:4677
NCIt40 C26805
ICD9CM27 370.9, 370
MeSH35 D007634
OMIM47 148190
MESH via Orphanet36 C537022
ICD10 via Orphanet26 H16.8
UMLS via Orphanet62 C1835698
ICD1025 H16, H16.9

Related Diseases for Keratitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Keratitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 313)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis30.5CD69, CXCL9, IL17A
2arthritis30.3CCL20, IL17RA, IL17A, CXCL9, CD69, CXCL2
3squamous cell carcinoma30.1CCR6, TKT, GJB2, DEFB4A, CXCL9, CXCL1
4tuberculosis30.0IL17A, DEFB4A, CXCL9, TLR9, CD69, TKT
5systemic lupus erythematosus30.0IL17A, TLR9, TNFSF4, CD69
6vaccinia29.9DARC
7atopic dermatitis29.6CCL20, TLR9, DEFB4A, IL17A, CXCL9, CD69
8atherosclerosis29.6IL17A, CXCL9, CXCL1, TLR9
9hepatitis c29.6CCL20
10sjogren's syndrome29.6CXCL9
11vasculitis29.6CXCL1, IL17A, TNFSF4
12acanthamoeba keratitis11.1
13stromal keratitis10.9
14herpes simplex virus keratitis10.8
15superficial keratitis10.6
16filamentary keratitis10.5
17mycobacterium chelonae10.5
18exposure keratitis10.4
19kid syndrome10.4
20n syndrome10.4
21conn's syndrome10.3
22syphilis10.3
23iritis10.3
24vernal keratitis10.3
25herpes zoster10.3
26sclerosing keratitis10.3
27corneal disease10.2
28acanthamoeba infection10.2
29cogan's syndrome10.2
30mycobacterium fortuitum10.2
31stenotrophomonas maltophilia10.2
32anterior uveitis10.2
33keratitis, hereditary10.2
34herpes zoster ophthalmicus10.2
35macular keratitis10.2
36bacterial conjunctivitis10.2
37bullous keratopathy10.1
38gonococcal keratitis10.1
39mycobacterium abscessus10.1
40vernal keratoconjunctivitis10.1
41blindness10.1
42keratoconjunctivitis sicca10.1
43keratomalacia10.1
44aniridia10.1
45punctate epithelial keratoconjunctivitis10.1
46hidradenitis suppurativa10.1
47erythema elevatum diutinum10.1
48limbal stem cell deficiency10.0
49rosacea10.0
50chronic granulomatous disease10.0

Graphical network of the top 20 diseases related to Keratitis:



Diseases related to keratitis

Clinical Features for Keratitis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

148190

Clinical synopsis from OMIM:

148190

Drugs & Therapeutics for Keratitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Keratitis

Drug clinical trials:

Search ClinicalTrials for Keratitis

Search NIH Clinical Center for Keratitis

Search CenterWatch for Keratitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Keratitis

Anatomical Context for Keratitis

Animal Models for Keratitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Keratitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.7PAX6, TLR9, TNFSF4, KERA, AIMP1, CD69

Publications for Keratitis

Sources:
51PubMed
See all sources

Articles related to Keratitis:

(show top 50)    (show all 1891)
idTitleAuthorsYear
1
Impending corneal perforation after collagen cross-linking for herpetic keratitis. (23522585)
2013
2
Lithium chloride promotes host resistance against Pseudomonas aeruginosa keratitis. (23878501)
2013
3
In vitro comparison of combination and monotherapy for the empiric and optimal coverage of bacterial keratitis based on incidence of infection. (23132444)
2013
4
Phenotypic and genotypic characterization of acyclovir-resistant corneal HSV-1 isolates from immunocompetent patients with recurrent herpetic keratitis. (23731845)
2013
5
Fusarium keratitis: genotyping, in vitro susceptibility and clinical outcomes. (23343947)
2013
6
Acyclovir-resistant herpetic keratitis in a solid-organ transplant recipient on systemic immunosuppression. (23386782)
2013
7
lukSF-PV in Staphylococcus aureus keratitis isolates and association with clinical outcome. (23580488)
2013
8
Riboflavin/ultravoilet light-mediated crosslinking for fungal keratitis. (23355529)
2013
9
Ganciclovir ophthalmic gel 0.15%: safety and efficacy of a new treatment for herpes simplex keratitis. (22607463)
2012
10
A new method to predict the epidemiology of fungal keratitis by monitoring the sales distribution of antifungal eye drops in Brazil. (22457787)
2012
11
Effects of lactoferricin B against keratitis-associated fungal biofilms. (22410856)
2012
12
Management and treatment of contact lens-related Pseudomonas keratitis. (22791973)
2012
13
Fungal keratitis caused by Colletotrichum spp. A presentation of case. (24269408)
2012
14
The changing spectrum of microbial keratitis: is microsporia increasing as a cause of microbial keratitis or is it a previously unrecognised cause? (22457272)
2012
15
Idiopathic peripheral necrotizing keratitis after femtosecond laser in situ keratomileusis. (22265184)
2012
16
Bilateral microbial keratitis in highly active antiretroviral therapy-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: a case series. (21834698)
2011
17
Treatment for fungal endophthalmitis resulting from keratitis. (21163378)
2011
18
Photographic monitoring of herpes simplex virus keratitis during anti-inflammatory treatment. (21320979)
2011
19
A case of suture-related bacterial keratitis and its treatment with topical imipenem. (23505593)
2011
20
Association between unilateral quiescent stromal herpetic keratitis and bilateral dry eyes. (20802319)
2010
21
Herpetic keratitis after descemet stripping automated endothelial keratoplasty for failed graft. (19125048)
2009
22
Management of herpes simplex virus stromal keratitis: an evidence-based review. (19298901)
2009
23
Good visual outcome after prompt treatment of acanthamoeba keratitis associated with overnight orthokeratology lens wear. (17993830)
2007
24
Epidemiological characteristics of a Chicago-area Acanthamoeba keratitis outbreak. (16876498)
2006
25
Infectious keratitis caused by Stenotrophomonas maltophilia and yeast simultaneously. (17172906)
2006
26
The pathophysiology of Acanthamoeba keratitis. (16500148)
2006
27
Improvement of herpetic stromal keratitis with fumaric acid derivate is associated with systemic induction of T helper 2 cytokines. (16178874)
2005
28
Herpes simplex virus keratitis after laser in situ keratomileusis. (16128340)
2005
29
Transplantation of amniotic membrane in murine herpes stromal keratitis modulates matrix metalloproteinases in the cornea. (16249483)
2005
30
Impression cytology in the diagnosis of acanthamoeba keratitis with surface involvement. (14962424)
2004
31
A novel combination treatment of chlorhexidine gluconate, natamycin (pimaricin) and debridement for a Acanthamoeba keratitis. (14636856)
2003
32
Missense mutations in GJB2 encoding connexin-26 cause the ectodermal dysplasia keratitis-ichthyosis-deafness syndrome. (11912510)
2002
33
Treatment of advanced acanthamoeba keratitis with deep lamellar keratectomy and conjunctival flap. (12352090)
2002
34
Images in clinical medicine. Interstitial keratitis as the initial expression of syphilitic reactivation. (12050340)
2002
35
Patient characteristics, diagnosis, and treatment of non-contact lens related Acanthamoeba keratitis. (11004092)
2000
36
Confirmation of confocal microscopy diagnosis of Acanthamoeba keratitis using polymerase chain reaction analysis. (10676782)
2000
37
Recurrent herpetic keratitis induced by laser iridectomy: case report. (10584428)
1999
38
Mycotic keratitis in non-steroid exposed vernal keratoconjunctivitis. (10321546)
1999
39
Prevention of herpes simplex keratitis and iritis. (9488290)
1998
40
Role of mucosal IgA in the resistance to Acanthamoeba keratitis. (9856776)
1998
41
Absence of macrophage inflammatory protein-1alpha prevents the development of blinding herpes stromal keratitis. (9557652)
1998
42
Successful medical treatment of Acanthamoeba keratitis. (9700010)
1997-1998
43
A clinicopathologic study of in vitro sensitivity testing and Acanthamoeba keratitis. (8125716)
1994
44
Fungal keratitis due to Scopulariopsis brevicaulis in an eye previously suffering from herpetic keratitis. (7845651)
1994
45
Diagnosis of acanthamoeba keratitis--a report of four cases and review of literature. (2201624)
1990
46
Recurrent Acanthamoeba keratitis following penetrating keratoplasty. (2222281)
1990
47
Therapeutic effect of corneal replicas in herpetic keratitis. (540190)
1979
48
Retained Descemet's membrane after keratoplasty for old interstitial keratitis. (4577690)
1973
49
Necrotizing keratitis (keratomalacia) with corneal perforation and expulsive uveal hemorrhage in a new-born. (5755680)
1968
50
Case of Interstitial Keratitis accompanied by Periostitis of the Tibia due to Congenital Syphilis. (19985313)
1926

Genetic Variations for Keratitis

Expression for genes affiliated with Keratitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Keratitis

Search GEO for disease gene expression data for Keratitis.

Pathways for genes affiliated with Keratitis

Sources:
52QIAGEN, 30KEGG, 54Reactome, 38NCBI BioSystems Database, 53R&D Systems
See all sources

Pathways related to Keratitis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6CCR6, IL17RA, IL17A, CXCL9, CXCL2, CXCL1
2
Hide members
10.6TNFSF4, CCL20, CCR6, CXCL1, CXCL2, CXCL9
3
Hide members
10.5CCR6, CCL20, TLR9, TNFSF4, CXCL1, CXCL2
4
Hide members
10.5CXCL2, CCR6, CCL20, CXCL9, TNFSF4, CXCL1
5
Hide members
10.5CXCL9, CXCL1, DARC, CCL20, CCR6, CXCL2
6
Hide members
10.5IL17RA, TLR9, IL17A
7
Hide members
10.5CCR6, CXCL1, CXCL2, CXCL9, CCL20
8
Hide members
10.5CCR6, CXCL9, CXCL2, CXCL1, CCL20
910.5CCL20, CXCL1, CXCL2, CXCL9, CCR6
10
Cytokine production by Th17 cells in CF (Mouse model)
10.5CXCL1, IL17RA, IL17A
1110.5IL17A, CXCL1, CCL20
1210.5CCL20, CXCL1, CXCL2

Compounds for genes affiliated with Keratitis

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Keratitis according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1rantes4510.9DARC, CCR6, CCL20, DEFB4A, CXCL1, CXCL2
2endotoxin4510.9CCL20, TLR9, DEFB4A, CXCL1, CXCL2, CXCL9
3vegf4510.9CCR6, CCL20, CXCL1, CXCL2, CXCL9, IL17A
4ccl445 2911.9CCR6, CCL20, CXCL2, CXCL9, IL17A
5tarc4510.9CCR6, CCL20, CXCL1, CXCL2, CXCL9
6lipid4510.9LCN1, CCR6, DEFB4A, CD69, CXCL2, IL17A
7ccl345 2911.9CXCL9, CXCL2, CXCL1, TLR9, CCL20
8calcium45 50 11 2413.9LCN1, CCR6, CCL20, DEFB4A, CD69, CXCL1
9nitric oxide45 11 2412.9CCL20, TLR9, CD69, CXCL1, CXCL2, CXCL9
10groalpha4510.9CXCL1, CXCL2, CXCL9, IL17A
11dexamethasone45 50 29 1113.8CCL20, DEFB4A, CXCL1, CXCL2, CXCL9
12tyrosine4510.8TLR9, DEFB4A, CD69, CXCL1, CXCL2, CXCL9
13flagellin45 2911.8CCL20, TLR9, DEFB4A
14pd 98,0594510.8DEFB4A, CD69, CXCL1, CXCL2, IL17A
15mip-3alpha4510.8CCL20, CCR6
16poly(i-c)4510.7CCL20, TLR9, CD69
17peptidoglycan45 2911.7DEFB4A, TLR9, CCL20
18methotrexate45 50 1112.7CD69, CXCL1, IL17A, TKT
19creatinine4510.7LCN1, CD69, CXCL9, IL17A, TKT
20grogamma4510.6CXCL2, CXCL1
21sb 20358045 6011.6DEFB4A, CXCL1, CXCL2, IL17A
22larc4510.5CCL20, CCR6
23grobeta4510.5CXCL2, CXCL1
24sp 60012545 6011.4IL17A, CXCL2, DEFB4A
25oligonucleotide4510.2CCL20, TLR9, CXCL1, CXCL2, IL17A

GO Terms for genes affiliated with Keratitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6LCN1, CCL20, TLR9, KERA, DEFB4A, CXCL1
2extracellular spaceGO:00561510.3CCL20, TNFSF4, AIMP1, CXCL1, CXCL2, CXCL9

Biological processes related to Keratitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.8CXCL9, CCR6, CCL20, DEFB4A, AIMP1, CXCL1
2inflammatory responseGO:00695410.8CCL20, TLR9, AIMP1, CXCL1, CXCL2, CXCL9
3immune responseGO:00695510.8CCR6, CCL20, DEFB4A, CXCL1, CXCL2, CXCL9
4cell-cell signalingGO:00726710.7CCL20, AIMP1, CXCL9, IL17A, GJB2
5fibroblast activationGO:07253710.7IL17A, IL17RA
6positive regulation of interleukin-23 productionGO:03274710.7IL17RA, IL17A
7positive regulation of cytokine production involved in inflammatory responseGO:190001710.6IL17A, IL17RA
8response to molecule of bacterial originGO:00223710.6CXCL2, TLR9
9cornea development in camera-type eyeGO:06130310.5KERA, PAX6
10positive regulation of interleukin-10 productionGO:03273310.5TNFSF4, TLR9
11signal transductionGO:00716510.4CCR6, CCL20, TNFSF4, AIMP1, CXCL1, CXCL9
12defense response to bacteriumGO:04274210.2DEFB4A, TLR9, CCL20

Molecular functions related to Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.5CXCL9, CXCL2, CXCL1, CCL20
2chemokine receptor activityGO:00495010.5DARC, CCR6
3cytokine activityGO:00512510.4TNFSF4, AIMP1, CXCL9, IL17A
4transmembrane signaling receptor activityGO:00488810.2DARC, CD69, TLR9

Products for genes affiliated with Keratitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Keratitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet