MCID: KRT004
MIFTS: 69

Keratitis malady

Genetic diseases, Rare diseases, Eye diseases categories

Summaries for Keratitis

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OMIM:47 Keratitis is a rare ocular disorder presenting with congenital and progressive features predominantly involving the... (148190) more...

MalaCards based summary: Keratitis, also known as hereditary keratitis, is related to rheumatoid arthritis and vasculitis, and has symptoms including autosomal dominant inheritance, keratitis and opacification of the corneal stroma. An important gene associated with Keratitis is PAX6 (paired box 6), and among its related pathways are Th17 Differentiation and IL-17 Family Signaling Pathways. The drugs tropicamide and loteprednol etabonate and the compounds ganciclovir and thymidine have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related mouse phenotypes are vision/eye and no phenotypic analysis.

Wikipedia:65 Keratitis is a condition in which the eye\'s cornea, the front part of the eye, becomes inflamed. The... more...

Aliases & Classifications for Keratitis

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Sources:
47OMIM, 10Disease Ontology, 11diseasecard, 12DISEASES, 45Novoseek, 62UMLS, 43NIH Rare Diseases, 49Orphanet, 24GTR, 57SNOMED-CT, 40NCIt, 29ICD9CM, 35MeSH, 36MESH via Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet, 27ICD10
See all sources

Keratitis, Aliases & Descriptions:

Name: Keratitis 47 10 11 12 45 62
Hereditary Keratitis 43 49 24
Autosomal Dominant Keratitis 43 49
 
Keratitis, Hereditary 43 62
Dominantly Inherited Keratitis 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Eye diseases
Orphanet: 49 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

49
hereditary keratitis:
Inheritance: Autosomal dominant; Age of onset: Childhood; Age of death: normal life expectancy


External Ids:

OMIM47 148190
Disease Ontology10 DOID:4677
NCIt40 C26805
ICD9CM29 370.9, 370
MeSH35 D007634
Orphanet49 2334
MESH via Orphanet36 C537022
ICD10 via Orphanet28 H16.8
UMLS via Orphanet63 C1835698
ICD1027 H16, H16.9

Related Diseases for Keratitis

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Graphical network of the top 20 diseases related to Keratitis:



Diseases related to keratitis

Symptoms for Keratitis

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Symptoms by clinical synopsis from OMIM:

148190

Clinical features from OMIM:

148190

HPO human phenotypes related to Keratitis:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 keratitis HP:0000491
3 opacification of the corneal stroma HP:0007759

Drugs & Therapeutics for Keratitis

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Drug clinical trials:

Search ClinicalTrials for Keratitis

Search NIH Clinical Center for Keratitis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Keratitis

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Genetic tests related to Keratitis:

id Genetic test Affiliating Genes
1 Keratitis, Hereditary24

Anatomical Context for Keratitis

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MalaCards organs/tissues related to Keratitis:

33
Eye, T cells, Endothelial, Testes, Neutrophil, B cells, Lymph node, Retina, Liver, Skin, Bone marrow, Bone, Brain, Thyroid, Myeloid

Animal Models for Keratitis or affiliated genes

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MGI Mouse Phenotypes related to Keratitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.8PAX6, GJB2, TKT, KERA
2MP:00030128.5GJB2, IL17RA, IL17A, MFF
3MP:00053977.8KERA, IL17RA, IL17A, CCR6, TNFSF4
4MP:00053767.2AIMP1, TNFSF4, PAX6, CCR6, IL17A, IL17RA
5MP:00053876.8KERA, AIMP1, TNFSF4, PAX6, CCR6, IL17A

Publications for Keratitis

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Articles related to Keratitis:

(show top 50)    (show all 1956)
idTitleAuthorsYear
1
Treatment of keratitis-ichthyosis- deafness (KID) syndrome in children: a case report and review of the literature. (25546246)
2015
2
Femtosecond Laser-Assisted Anterior Lamellar Keratoplasty in Stromal Keratitis Caused by an Endoreticulatus-like Microsporidia. (25826328)
2015
3
I^I' T cells regulate the expression of cytokines but not the manifestation of fungal keratitis. (25864785)
2015
4
Trends in Microbiological and Antibiotic Sensitivity Patterns in Infectious Keratitis: 10-Year Experience in Mexico City. (25811724)
2015
5
Acanthamoeba keratitis: a new normal. (25012982)
2014
6
Alternaria keratitis and hypopyon after clear-cornea phacoemulsification. (24461506)
2014
7
Corneal collagen crosslinking and herpetic keratitis. (23889879)
2013
8
Actinomyces bowdenii ulcerative keratitis in a dog. (23121462)
2013
9
Recurrent non-tuberculous mycobacterial keratitis after deep anterior lamellar keratoplasty for keratoconus. (24136909)
2013
10
Acanthamoeba keratitis: study of the 5-year incidence in Israel. (23878134)
2013
11
Isolation and characterization of a new fungal genus and species, Aphanoascella galapagosensis, from carapace keratitis of a Galapagos tortoise (Chelonoidis nigra microphyes). (22852752)
2013
12
Severe ulcerative keratitis in ocular cowpox infection. (22932773)
2013
13
Herpes Simplex epithelial keratitis associated with daily disposable contact lens wear. (24333040)
2013
14
Inhibition of Ataxia Telangiectasia Mutated (ATM) Kinase Suppresses Herpes Simplex Virus Type 1 (HSV-1) Keratitis. (24370835)
2013
15
An unusual case of peripheral ulcerative keratitis as a presenting feature in an otherwise healthy patient with undiagnosed human immunodeficiency virus infection and low CD4 counts. (23514657)
2013
16
Modulation of immune signaling, bacterial clearance, and corneal integrity by toll-like receptors during streptococcus pneumoniae keratitis. (23841825)
2013
17
Therapeutic effect of deep anterior lamellar keratoplasty for active or quiescent herpetic stromal keratitis. (22349979)
2012
18
Chronic recalcitrant bacterial infection in steroid modified interstitial (stromal) keratitis: presentation and management. (23252209)
2012
19
A case of nocardia keratitis treated successfully with topical amikacin. (22344016)
2012
20
Bowman's layer encystment in cases of persistent Acanthamoeba keratitis. (22927735)
2012
21
Fungal keratitis caused by Chaetomium atrobrunneum. (22045390)
2012
22
Interstitial keratitis secondary to severe hidradenitis suppurativa responding to adalimumab. (22146546)
2012
23
Medical interventions for fungal keratitis. (22336802)
2012
24
Radial keratoneuritis as a presenting sign in acanthamoeba keratitis. (21887085)
2011
25
Interstitial keratitis secondary to severe hidradenitis suppurativa: a case report and literature review. (20628295)
2010
26
New-onset herpes simplex virus keratitis after cataract surgery. (19092420)
2009
27
Herpetic keratitis after descemet stripping automated endothelial keratoplasty for failed graft. (19125048)
2009
28
A rare connexin 26 mutation in a patient with a forme fruste of keratitis-ichthyosis-deafness (KID) syndrome. (19785089)
2009
29
Fusarium and Acanthamoeba keratitis: can a single centre detect outbreaks? (18441185)
2008
30
The application of in vivo confocal scanning laser microscopy in the management of Acanthamoeba keratitis. (17679934)
2007
31
Good visual outcome after prompt treatment of acanthamoeba keratitis associated with overnight orthokeratology lens wear. (17993830)
2007
32
Impression cytology in the diagnosis of acanthamoeba keratitis with surface involvement. (14962424)
2004
33
Bilateral deep keratitis caused by systemic lupus erythematosus. (15075893)
2004
34
Corneal epithelial cells and stromal keratocytes efficently produce CC chemokine-ligand 20 (CCL20) and attract cells expressing its receptor CCR6 in mouse herpetic stromal keratitis. (15287366)
2004
35
Non-contact lens related Acanthamoeba keratitis at a tertiary eye care center in south India: Implications for eye care programs in the region. (12709670)
2003
36
Persistence of acanthamoeba antigen following acanthamoeba keratitis. (11222330)
2001
37
Classification of herpes simplex virus keratitis and anterior uveitis. (10090358)
1999
38
Acanthamoeba keratitis and contact lens wear. (9371196)
1997
39
Keratitis, ichthyosis, and deafness (KID syndrome): review of the literature and proposal of a new terminology. (9122065)
1996
40
Acinetobacter exposure keratitis. (8060938)
1994
41
Murine herpes simplex virus keratitis is accentuated by CD4+, V beta 8.2+ Th2 T cells. (7908153)
1993
42
Acanthamoeba keratitis: experience in a non-specialist microbiology laboratory. (1890209)
1991
43
Filamentary keratitis--the clinical challenges. (1813523)
1991
44
Recurrent herpetic keratitis: failure to detect herpes simplex virus infection using the Syva MicroTrak HSV1/HSV2 direct specimen identification/typing test. (1963928)
1990
45
Immunobiology of Langerhans cells on the ocular surface. II. Role of central corneal Langerhans cells in stromal keratitis following experimental HSV-1 infection in mice. (2561960)
1989
46
Management of herpetic keratitis. (7046194)
1982
47
HLA antigens in recurrent stromal herpes simplex virus keratitis. (7356786)
1980
48
Management of resistant cases of herpetic keratitis using cryo-immunotherapy technique. (1031073)
1976
49
Some aspects of interstitial keratitis. (15410175)
1950
50
Eczematous keratitis and ariboflavinosis. (18103821)
1948

Variations for Keratitis

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Expression for genes affiliated with Keratitis

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Search GEO for disease gene expression data for Keratitis.

Pathways for genes affiliated with Keratitis

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Compounds for genes affiliated with Keratitis

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Sources:
45Novoseek, 13DrugBank, 26HMDB, 30IUPHAR
See all sources

Compounds related to Keratitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ganciclovir45 1310.5TKT, GJB2
2thymidine45 2610.4TKT, GJB2, IL17A
3ccl445 3010.2CCR6, IL17A
4rantes458.8IL17RA, IL17A, CCR6
5vegf458.7TKT, IL17A, CCR6, PAX6

GO Terms for genes affiliated with Keratitis

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Cellular components related to Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:00057779.5TKT, MFF

Biological processes related to Keratitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cornea development in camera-type eyeGO:00613039.8KERA, PAX6
2fibroblast activationGO:00725379.7IL17RA, IL17A
3response to woundingGO:00096119.7PAX6, AIMP1
4positive regulation of interleukin-23 productionGO:00327479.7IL17RA, IL17A
5positive regulation of cytokine production involved in inflammatory responseGO:019000179.6IL17RA, IL17A
6cell-cell signalingGO:00072679.2AIMP1, IL17A, GJB2
7immune responseGO:00069558.5IL17A, CCR6, TNFSF4

Molecular functions related to Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.1IL17A, TNFSF4, AIMP1

Products for genes affiliated with Keratitis

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  • Antibodies
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  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Keratitis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet