MCID: KRT004
MIFTS: 62

Keratitis malady

Eye diseases, Rare diseases categories
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Summaries for Keratitis

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Wikipedia:65 Keratitis is a condition in which the eye\'s cornea, the front part of the eye, becomes inflamed. The... more...

MalaCards based summary: Keratitis, also known as autosomal dominant keratitis, is related to vasculitis and rheumatoid arthritis, and has symptoms including An important gene associated with Keratitis is PAX6 (paired box 6), and among its related pathways are Th17 Differentiation and IL-17 Family Signaling Pathways. The drugs tropicamide and loteprednol etabonate and the compounds ganciclovir and thymidine have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related mouse phenotypes are vision/eye and no phenotypic analysis.

Description from OMIM:46 148190

Aliases & Classifications for Keratitis

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Sources:
8Disease Ontology, 9diseasecard, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Keratitis, Aliases & Descriptions:

Name: Keratitis 8 9 46 10 44 62
Autosomal Dominant Keratitis 48
 
Keratitis, Hereditary 62
Hereditary Keratitis 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 48 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

48
autosomal dominant keratitis:
Inheritance: Autosomal dominant; Age of onset: Childhood; Age of death: Normal


External Ids:

Disease Ontology8 DOID:4677
ICD9CM27 370.9, 370
MeSH34 D007634
NCIt39 C26805
OMIM46 148190
MESH via Orphanet35 C537022
ICD10 via Orphanet26 H16.8
UMLS via Orphanet63 C1835698
ICD1025 H16, H16.9

Related Diseases for Keratitis

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Graphical network of the top 20 diseases related to Keratitis:



Diseases related to keratitis

Symptoms for Keratitis

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Symptoms by clinical synopsis from OMIM:

148190

Clinical features from OMIM:

148190

HPO human phenotypes related to Keratitis:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 keratitis HP:0000491
3 opacification of the corneal stroma HP:0007759

Drugs & Therapeutics for Keratitis

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Drug clinical trials:

Search ClinicalTrials for Keratitis

Search NIH Clinical Center for Keratitis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Keratitis

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Anatomical Context for Keratitis

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MalaCards organs/tissues related to Keratitis:

32
Eye, T cells, Endothelial, Testes, Neutrophil, B cells, Lymph node, Retina, Liver, Skin, Bone marrow, Bone, Brain, Thyroid, Myeloid

Animal Models for Keratitis or affiliated genes

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MGI Mouse Phenotypes related to Keratitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.8TKT, GJB2, PAX6, KERA
2MP:00030128.5GJB2, IL17RA, IL17A, MFF
3MP:00053977.8CCR6, IL17A, IL17RA, KERA, TNFSF4
4MP:00053767.2PAX6, GJB2, IL17RA, IL17A, AIMP1, CCR6
5MP:00053876.8IL17A, PAX6, CCR6, AIMP1, IL17RA, GJB2

Publications for Keratitis

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Articles related to Keratitis:

(show top 50)    (show all 1924)
idTitleAuthorsYear
1
Acanthamoeba keratitis: a new normal. (25012982)
2014
2
Alternaria keratitis and hypopyon after clear-cornea phacoemulsification. (24461506)
2014
3
Resistant Microbial Keratitis in South Nile Delta, Egypt: Influence of Regional Risk Factors. (25398124)
2014
4
Corneal collagen crosslinking and herpetic keratitis. (23889879)
2013
5
Actinomyces bowdenii ulcerative keratitis in a dog. (23121462)
2013
6
Recurrent non-tuberculous mycobacterial keratitis after deep anterior lamellar keratoplasty for keratoconus. (24136909)
2013
7
Acanthamoeba keratitis: study of the 5-year incidence in Israel. (23878134)
2013
8
Isolation and characterization of a new fungal genus and species, Aphanoascella galapagosensis, from carapace keratitis of a Galapagos tortoise (Chelonoidis nigra microphyes). (22852752)
2013
9
Severe ulcerative keratitis in ocular cowpox infection. (22932773)
2013
10
Herpes Simplex epithelial keratitis associated with daily disposable contact lens wear. (24333040)
2013
11
Inhibition of Ataxia Telangiectasia Mutated (ATM) Kinase Suppresses Herpes Simplex Virus Type 1 (HSV-1) Keratitis. (24370835)
2013
12
An unusual case of peripheral ulcerative keratitis as a presenting feature in an otherwise healthy patient with undiagnosed human immunodeficiency virus infection and low CD4 counts. (23514657)
2013
13
Modulation of immune signaling, bacterial clearance, and corneal integrity by toll-like receptors during streptococcus pneumoniae keratitis. (23841825)
2013
14
Therapeutic effect of deep anterior lamellar keratoplasty for active or quiescent herpetic stromal keratitis. (22349979)
2012
15
Chronic recalcitrant bacterial infection in steroid modified interstitial (stromal) keratitis: presentation and management. (23252209)
2012
16
A case of nocardia keratitis treated successfully with topical amikacin. (22344016)
2012
17
Bowman's layer encystment in cases of persistent Acanthamoeba keratitis. (22927735)
2012
18
Fungal keratitis caused by Chaetomium atrobrunneum. (22045390)
2012
19
Interstitial keratitis secondary to severe hidradenitis suppurativa responding to adalimumab. (22146546)
2012
20
Medical interventions for fungal keratitis. (22336802)
2012
21
Radial keratoneuritis as a presenting sign in acanthamoeba keratitis. (21887085)
2011
22
Interstitial keratitis secondary to severe hidradenitis suppurativa: a case report and literature review. (20628295)
2010
23
New-onset herpes simplex virus keratitis after cataract surgery. (19092420)
2009
24
Herpetic keratitis after descemet stripping automated endothelial keratoplasty for failed graft. (19125048)
2009
25
A rare connexin 26 mutation in a patient with a forme fruste of keratitis-ichthyosis-deafness (KID) syndrome. (19785089)
2009
26
Fusarium and Acanthamoeba keratitis: can a single centre detect outbreaks? (18441185)
2008
27
The application of in vivo confocal scanning laser microscopy in the management of Acanthamoeba keratitis. (17679934)
2007
28
Good visual outcome after prompt treatment of acanthamoeba keratitis associated with overnight orthokeratology lens wear. (17993830)
2007
29
Impression cytology in the diagnosis of acanthamoeba keratitis with surface involvement. (14962424)
2004
30
Bilateral deep keratitis caused by systemic lupus erythematosus. (15075893)
2004
31
Corneal epithelial cells and stromal keratocytes efficently produce CC chemokine-ligand 20 (CCL20) and attract cells expressing its receptor CCR6 in mouse herpetic stromal keratitis. (15287366)
2004
32
Non-contact lens related Acanthamoeba keratitis at a tertiary eye care center in south India: Implications for eye care programs in the region. (12709670)
2003
33
Recent advances in the treatment of Acanthamoeba keratitis. (12145728)
2002
34
Persistence of acanthamoeba antigen following acanthamoeba keratitis. (11222330)
2001
35
Control of stromal keratitis by inhibition of neovascularization. (11549594)
2001
36
Classification of herpes simplex virus keratitis and anterior uveitis. (10090358)
1999
37
Acanthamoeba keratitis and contact lens wear. (9371196)
1997
38
Keratitis, ichthyosis, and deafness (KID syndrome): review of the literature and proposal of a new terminology. (9122065)
1996
39
Chemotherapy for acanthamoeba keratitis. (7891502)
1995
40
Acinetobacter exposure keratitis. (8060938)
1994
41
Murine herpes simplex virus keratitis is accentuated by CD4+, V beta 8.2+ Th2 T cells. (7908153)
1993
42
Acanthamoeba keratitis: experience in a non-specialist microbiology laboratory. (1890209)
1991
43
Filamentary keratitis--the clinical challenges. (1813523)
1991
44
Recurrent herpetic keratitis: failure to detect herpes simplex virus infection using the Syva MicroTrak HSV1/HSV2 direct specimen identification/typing test. (1963928)
1990
45
Immunobiology of Langerhans cells on the ocular surface. II. Role of central corneal Langerhans cells in stromal keratitis following experimental HSV-1 infection in mice. (2561960)
1989
46
Management of herpetic keratitis. (7046194)
1982
47
HLA antigens in recurrent stromal herpes simplex virus keratitis. (7356786)
1980
48
Management of resistant cases of herpetic keratitis using cryo-immunotherapy technique. (1031073)
1976
49
Some aspects of interstitial keratitis. (15410175)
1950
50
Eczematous keratitis and ariboflavinosis. (18103821)
1948

Variations for Keratitis

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Expression for genes affiliated with Keratitis

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Expression patterns in normal tissues for genes affiliated with Keratitis

Search GEO for disease gene expression data for Keratitis.

Pathways for genes affiliated with Keratitis

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Compounds for genes affiliated with Keratitis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR
See all sources

Compounds related to Keratitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ganciclovir44 1110.5TKT, GJB2
2thymidine44 2410.4TKT, GJB2, IL17A
3ccl444 2810.2CCR6, IL17A
4rantes448.8IL17RA, IL17A, CCR6
5vegf448.7TKT, IL17A, CCR6, PAX6

GO Terms for genes affiliated with Keratitis

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Cellular components related to Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057779.5TKT, MFF

Biological processes related to Keratitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cornea development in camera-type eyeGO:0613039.8KERA, PAX6
2fibroblast activationGO:0725379.7IL17RA, IL17A
3response to woundingGO:0096119.7PAX6, AIMP1
4positive regulation of interleukin-23 productionGO:0327479.7IL17RA, IL17A
5positive regulation of cytokine production involved in inflammatory responseGO:19000179.6IL17RA, IL17A
6cell-cell signalingGO:0072679.2AIMP1, IL17A, GJB2
7immune responseGO:0069558.5IL17A, CCR6, TNFSF4

Molecular functions related to Keratitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL17A, TNFSF4, AIMP1

Products for genes affiliated with Keratitis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Keratitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet