Keratitis malady

Genetics Home Reference: Keratitis-ichthyosis-deafness (KID) syndrome is characterized by eye problems, skin abnormalities, and hearing loss.¹⁷

MalaCards: Keratitis, also known as keratitis nos (disorder), is related to herpetic keratitis and interstitial keratitis. An important gene associated with Keratitis is PAX6 (paired box 6), and among its related pathways are Bacterial infections in CF airways and RAR-Gamma-RXR-Alpha Degradation. The drugs loteprednol and tropicamide and the compounds calcium and sp 600125 have been mentioned in the context of this disorder. Affiliated tissues include skin and t cells, and related mouse phenotypes are respiratory system and renal/urinary system.

Wikipedia: Keratitis is a condition in which the eye\'s cornea, the front part of the eye, becomes inflamed. The...⁴⁴ more...

OMIM: 148190

Aliases & Descriptions:

keratitis 6 7 8 33 32 43 keratitis nos (disorder) 6 unspecified keratitis 6

keratitis (disorder) 6 keratitis nos 6

Diseases related to keratitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 809)

id	Related Disease	Score	Top Affiliating Genes
1	herpetic keratitis	34.1	IL6, IFNA1, HLA-DPA1, HLA-DRA, DARC, NGF
2	interstitial keratitis	32.3	PBK, PTPRJ, COL9A1
3	ichthyosis	32.2	RELA, GJB2, GJB6, SNAP29, KRT16, KRT17
4	exposure keratitis	30.9	BGN, KERA, MBD5, HBEGF
5	dry eye syndrome	29.5	MUC4, CD44, IL6, NGF, LTF
6	pachyonychia congenita	28.5	KRT16, KRT17, KRT6B
7	corneal disease	28.3	IL1A, GJB2, NGF, KRT3
8	corneal ulcer	27.0	MMP2, MMP9, IL1B, NGF, TAT
9	erythema multiforme	27.0	ATF3, FAS, CCL2, ICAM1, TNF, CXCL9
10	ectodermal dysplasia	26.4	IL18, IL1B, GJA1, GJB2, GJB6, TNF
11	wegener's granulomatosis	26.1	CIITA, S100A8, IL17A, IL18, IL2RA, IL6
12	hearing loss	26.0	GUSB, GSR, FGF2, IL1A, IFNA1, IFNA2
13	herpes simplex	22.9	VEGFA, VDR, MYD88, T, JUN, CD4
14	genital herpes	13.9	T, IFNA1, HLA-B, DARC, TLR2, DEFB4A
15	corneal dystrophy	13.9	PAX6, KERA, KRT17, KRT3, LTF, TAT
16	epidermolytic hyperkeratosis	13.9	GJB2, KRT16, TGM1, DEFB4A
17	lymphomatoid granulomatosis	13.8	IFNA1, IFNA2, CXCL9
18	contact dermatitis	13.8	IL1A, IGHE, KRT16, CXCL9
19	palmoplantar keratosis	13.8	GJB2, GJB6, KRT6B, TAT
20	coccidioidomycosis	13.8	CD69, CD4, MBL2, TLR4
21	vohwinkel syndrome	13.8	GUSB, GJB2, TGM1
22	vulvovaginitis	13.8	MBL2, IGHE, HSPD1, LTF, DEFB4A
23	intestinal volvulus	13.7	GSR, HSPD1, TLR2
24	dental caries	13.7	MMP8, MBL2, LTF, OXA1L, CST1
25	pthirus pubis infestation	13.7	MIF, IGHE, NGF
26	radiculopathy	13.7	IL17A, IL1A, IL2RA, IL6, IFNA1, CXCL9
27	lymphosarcoma	13.6	BMI1, GSR, IL2RA, MBL2
28	factor v leiden thrombophilia	13.6	S100A8, MMP8, GSR, THBS1, TAT, OXA1L
29	mental retardation syndrome	13.6	PAX6, GUSB, IL1RAP, MBD4, EZH2, NGF
30	venezuelan equine encephalitis	13.6	CCL2, IFNA1, STAT2, STAT1
31	gastrointestinal system disease	13.6	S100A8, MIF, LTF, HBEGF
32	lymphangioma	13.6	IFNA2, HBA1, HBA2, OXA1L
33	herpes gestationis	13.6	JUN, GSR, DARC, TKT, TAT
34	melioidosis	13.6	MIF, IL18, IL1B, IL6, TLR10, TLR2
35	hypothyroidism, autoimmune	13.5	IL2RA, PTPRJ, CXCL9
36	sm-ahnmd	13.5	IL2RA, IFNA1, IFNA2, TKT, STAT5B
37	cryptosporidiosis	13.5	CD4, IL1A, MBL2, LTF
38	chronic ulcer of skin	13.5	MMP8, FGF2, EGF, DEFB4A
39	membranoproliferative glomerulonephritis type 2	13.5	IL6, CCL2, IFNA1, IFNA2, ICAM1
40	aggressive periodontitis	13.5	MMP8, IL1A, HLA-B, LTF
41	hyper-ige syndrome	13.5	MMP8, MMP9, IL17A, IL6, IGHE, TLR2
42	reactive arthritis	13.5	MMP8, HSPD1, HLA-B, LTF
43	bacteriuria	13.5	IL6, IL8, TLR2, TLR4
44	malt lymphoma	13.5	S100A8, IL6, HSPD1, TRB@, TLR2, TLR4
45	corneal edema	13.4	PBK, IL1B, FBXO7, DHX9
46	plasmodium falciparum malaria	13.4	MIF, GSR, IL18, ICAM1, HLA-B, THBS1
47	bullous keratopathy	13.4	PBK, KERA, MMP2, IL1A
48	autoimmune lymphoproliferative syndrome	13.4	CD4, IL2RA, FASLG, FAS, IGHE
49	21-hydroxylase deficiency	13.4	GUSB, IL2RA, IFNA1, IFNA2
50	stachybotrys chartarum	13.4	IL18, IL1A, IL1B, CXCL2

Clinical features from OMIM: 148190

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 loteprednol, loteprednol etabonate, natamycin, tropicamide

MalaCards organs/tissues related to keratitis:

²²

MGI Mouse Phenotypes related to keratitis:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	STAT5B, PTPRJ, PAX6, REL
2	renal/urinary system phenotype	MP:0005367	9.9	THBS1, TKT, TLR8, EGFR, CAV1, FAM20C
3	endocrine/exocrine gland phenotype	MP:0005379	9.9	TKT, TLR2, GJA1, CAV1, FAM20C, FASLG
4	craniofacial phenotype	MP:0005382	9.9	KRT6B, KRT16, PTPRJ, GJA1, MBD4, FAM20C
5	hematopoietic system phenotype	MP:0005397	9.6	FGF2, IL17A, IL17RA, FBXO7, FAM20C, CCR6
6	liver/biliary system phenotype	MP:0005370	9.2	TLR4, TLR2, EGFR, PTPRJ, TRB@, IL6
7	adipose tissue phenotype	MP:0005375	8.5	TKT, TLR4, TLR2, EGFR, TNF, CAV1
8	hearing/vestibular/ear phenotype	MP:0005377	8.4	GJB2, GJB6, COL9A1, NFKB1, EGFR, TLR4
9	nervous system phenotype	MP:0003631	8.2	CCR6, EZH2, CAV1, GJB2, GJB6, TRB@
10	limbs/digits/tail phenotype	MP:0005371	8.1	FAS, MBD4, GJB2, COL9A1, EGFR, TLR4
11	normal phenotype	MP:0002873	8.0	CCR6, EZH2, GJA1, TRB@, PTPRJ, HBEGF
12	digestive/alimentary phenotype	MP:0005381	7.3	T, CD4, CD44, MMP9, IL17A, IL18
13	immune system phenotype	MP:0005387	7.3	REL, MIF, IL6, FBXO7, MBD3, MBL2
14	reproductive system phenotype	MP:0005389	6.8	HSPD1, CAV1, GJA1, GJB2, TNF, PTPRJ
15	skeleton phenotype	MP:0005390	6.4	IL17A, STAT1, GGCX, THBS1, HBEGF, IL6
16	tumorigenesis	MP:0002006	6.0	MYD88, BMI1, PAX6, CD44, MMP2, MMP8
17	muscle phenotype	MP:0005369	5.9	GJA1, TNF, PTPRJ, NFKB1, EGFR, HBA2
18	vision/eye phenotype	MP:0005391	5.5	TNF, GJB2, GJA1, ICAM1, CCL2, MBD4
19	cellular phenotype	MP:0005384	5.2	TLR9, THBS1, DHX9, STAT2, STAT1, STAT5B
20	cardiovascular system phenotype	MP:0005385	4.4	RELA, VEGFA, VDR, MYD88, BMI1, PAX6
21	mortality/aging	MP:0010768	INF	STAT5B, CXCL9, GGCX, STAT1, GUSB, IL17A
22	behavior/neurological phenotype	MP:0005386	INF	KRT6B, KRT16, NFKB1, NGF, GJB6, HBEGF
23	growth/size phenotype	MP:0005378	INF	EGF, KRT6B, KRT16, NFKB1, NGF, PTPRJ
24	homeostasis/metabolism phenotype	MP:0005376	INF	CD44, MBD4, MBL2, MAP3K12, CCR6, CCL2
25	integument phenotype	MP:0010771	INF	KRT16, ROBO4, KRT17, KRT6B, EGF, EGFR

Articles related to keratitis:

(show top 50)    (show all 74)

id	Title	Authors	Year	Affiliating Genes
1	EGFR and IL-1 signaling synergistically promote kerat inocyte antimicrobial defenses in a differentiation-dependent manner. (20962853)	Johnston A.... Elder J.T.	2011	EGFR, IL1B
2	Increased expression of hepcidin and toll-like recept ors 8 and 10 in viral keratitis. (21499082)	Mohammed I.... Dua H.S.	2011	TLR8, TLR10, HAMP
3	Upregulation of MMP-9 production by TNFalpha in kerat inocytes and its attenuation by vitamin D. (20020446)	Bahar-Shany K.... Koren R.	2010	MMP9, TNF, JUN
4	Toll-like receptors involved in the pathogenesis of e xperimental Candida albicans keratitis. (19933194)	Yuan X.... Wilhelmus K.R.	2010	TLR2
5	Activating transcription factor 3 (ATF3) expression i s increased in erythema multiforme and is regulated by IFN-gamma in human kerat inocytes. (20002170)	Pollack B.P.... Haun P.L.	2010	ATF3
6	The tumor-suppressive function of Connexin43 in kerat inocytes is mediated in part via interaction with caveolin-1. (20406988)	Langlois S.... Laird D.W.	2010	EGF, GJA1, CAV1
7	Activation of Toll-like receptors 2 and 4 in Aspergil lus fumigatus keratitis. (19474209)	Jie Zhao .... Yu F.S.	2009	TLR2, TLR4
8	Pachyonychia congenita type 2, N92S mutation of kerat in 17 gene: clinical features, mutation analysis and pathological view. (19107515)	Cogulu O.... Ozkinay F.	2009	KRT17, KRT6B
9	Human papillomavirus type 16 infection of human kerat inocytes requires clathrin and caveolin-1 and is brefeldin a sensitive. (19494002)	Laniosz V.... Meneses P.I.	2009	CAV1
10	Tearfilm immunoglobulin E (IgE) level in vernal kerat oconjunctivitis by ELISA. (20071840)	Pokharel S.... Choudhary M.	2009	IGHE
11	A human apolipoprotein E mimetic peptide effectively inhibits HSV-1 TK-positive and TK-negative acute epithelial keratitis in rabbits. (19219680)	Bhattacharjee P.S.... Hill J.M.	2009	TKT
12	Beta-defensins 2 and 3 together promote resistance to Pseudomonas aeruginosa keratitis. (19933858)	Wu M.... Hazlett L.D.	2009	MBD4, MBD3, MBD2
13	Flagellin suppresses the inflammatory response and en hances bacterial clearance in a murine model of Pseudomonas aeruginosa keratiti s. (17938214)	Kumar A.... Yu F.S.	2008	IL1B
14	A familial case of Keratitis-Ichthyosis-Deafness (KID) syndrome with the GJB2 mutation G45E. (18024254)	Jonard L.... Hadj-Rabia S.	2008	GJB2
15	Comparative analysis of the tear protein profile in mycotic keratitis patients. (18385783)	Ananthi S.... Dharmalingam K.	2008	CST1
16	Connexin 26 mutation in keratitis-ichthyosis-deafness (KID) syndrome in mother and daughter with combined conductive and sensorineural hearing loss. (18412859)	Kelly B.... Makishima T.	2008	GJB2
17	Lactoferrin Glu561Asp polymorphism is associated with susceptibility to herpes simplex keratitis. (18022620)	Keijser S.... Nibbering P.H.	2008	LTF
18	Expression and function of the OX40/OX40L costimulatory pair during herpes stromal keratitis. (17185358)	Lepisto A.J.... Hendricks R.L.	2007	TNFSF4
19	The use of nerve growth factor in herpetic keratitis: a case report. (17974026)	Mauro C.... Emilio C.C.	2007	NGF
20	Matrix metalloproteinases (MMP-8, MMP-9) and the tissue inhibitors of metalloproteinases (TIMP-1, TIMP-2) in patients with fungal keratitis. (17251814)	Rohini G.... Muthukkaruppan V.	2007	MMP8
21	Keratitis-ichthyosis-deafness syndrome: disease expression and spectrum of connexin 26 (GJB2) mutations in 14 patients. (17381453)	Mazereeuw-Hautier J.... Hovnanian A.	2007	GJB2
22	Use of tear enzyme assay to predict recurrent herpet ic keratitis in children (17802756)	Terekhina N.A.... Petrovich I.u.A.	2007	GUSB
23	A novel N14Y mutation in Connexin26 in keratitis-ichthyosis-deafness syndrome: analyses of altered gap junctional communication and molecular structure of N terminus of mutated Connexin26. (16877344)	Arita K.... Shimizu H.	2006	GJB2
24	Cochleosaccular dysplasia associated with a connexin 26 mutation in keratitis-ichthyosis-deafness syndrome. (16885744)	Griffith A.J.... Merchant S.N.	2006	GJB2
25	Role of cytokines and chemokines in pseudomonal keratitis. (16227823)	Matsumoto K.... Tanihara H.	2005	IL18, S100A8
26	Efficacy and safety of 0.18% sodium hyaluronate in pa tients with moderate dry eye syndrome and superficial keratitis. (15965673)	Brignole F.... Baudouin C.	2005	CD44
27	A novel connexin 26 gene mutation associated with features of the keratitis-ichthyosis-deafness syndrome and the follicular occlusion triad. (15337980)	Montgomery J.R.... Holland S.M.	2004	GJB2
28	Identification of 18S ribosomal DNA genotype of Acanthamoeba from patients with keratitis in North China. (15161856)	Zhang Y.... Chen W.	2004	JDP2
29	Interaction of the hormonal and immunologic impairme nts in men with herpetic keratitis (15106381)	ZaA-nutdinova G.K.h.... Mal'khanov V.B.	2004	IL6
30	Mice transgenic for IL-1 receptor antagonist protein are resistant to herpetic stromal keratitis: possible role for IL-1 in herpetic stromal keratitis pathogenesis. (15004178)	Biswas P.S.... Rouse B.T.	2004	IL1RAP
31	Restricted T cell receptor beta-chain variable region protein use by cornea-derived CD4+ and CD8+ herpes simplex virus-specific T cells in patients with herpetic stromal keratitis. (12599071)	Maertzdorf J.... Osterhaus A.D.	2003	TRB@
32	De novo mutation in the gene encoding connexin-26 (GJB2) in a sporadic case of keratitis-ichthyosis-deafness (KID) syndrome. (12548749)	Alvarez A.... Tapia M.C.	2003	GJB2
33	Novel mutations in GJB2 encoding connexin-26 in Japanese patients with keratitis-ichthyosis-deafness syndrome. (12752120)	Yotsumoto S.... Kanzaki T.	2003	GJB2
34	Missense mutations in GJB2 encoding connexin-26 cause the ectodermal dysplasia keratitis-ichthyosis-deafness syndrome. (11912510)	Richard G.... Russell L.	2002	GJB2
35	The roles of inflammation, STAT transcription factors, and nerve growth factor in viral reactivation and herpes keratitis. (12167251)	Kriesel J.D.	2002	STAT1, STAT5B, STAT2
36	IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts. (12421973)	Maertzdorf J.... Verjans G.M.	2002	IL17A, IL17RA
37	Exacerbation of Acanthamoeba keratitis in animals treated with anti-macrophage inflammatory protein 2 or antineutrophil antibodies. (11292716)	Hurt M.... Alizadeh H.	2001	CXCL2
38	Expression of macrophage migration inhibitory factor during Pseudomonas keratitis. (11446464)	Thakur A.... Willcox M.D.	2001	MIF
39	Time course of interferon status of patients with herpetic keratitis during treatment with actipol, a new inteferon inducer (11339038)	Akberova S.I.... Mamedova V.M.	2001	IFNA1
40	Apoptosis in human non-necrotizing stromal herpes simplex keratitis (11076349)	Heiligenhaus A.... Steuhl K.P.	2000	FAS, FASLG
41	Corneal epithelial-specific cytokeratin 3 is an autoantigen in Wegener's granulomatosis-associated peripheral ulcerative keratitis. (10440272)	Reynolds I.... Hillarby M.C.	1999	KRT3
42	Are cytokine patterns in aqueous humour useful in distinguishing corneal graft rejection from opacification due to herpetic stromal keratitis? (11097120)	van Gelderen E.B.... Treffers W.F.	1999	LCN1
43	Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: analysis of clinical isolates from herpetic keratitis patients and laboratory strains. (9746072)	Kudo E.... Itakura M.	1998	TKT
44	22-Oxa calcitriol is a less potent regulator of kerat inocyte proliferation and differentiation due to decreased cellular uptake and enhanced catabolism. (7594646)	Bikle D.D.... Pillai S.	1995	VDR
45	Topical interferon alpha-2a treatment of herpes simpl ex keratitis resistant to multiple antiviral medications in an immunosuppressed patient. (7600820)	Minkovitz J.B.... Pepose J.S.	1995	IFNA2
46	Mutation of the PAX6 gene in patients with autosomal dominant keratitis. (7668281)	Mirzayans F.... Walter M.A.	1995	PAX6
47	Enzymatic analysis of lacrimal fluid in viral keratitis (7894897)	Terekhina N.A.... Reuk S.E.	1994	GSR
48	Intercellular adhesion molecule-1 (ICAM-1) and HLA-DR antigens in herpes keratitis. (1357614)	Elner V.M.... Elner S.G.	1992	ICAM1
49	Characterization of glycoprotein C-negative mutants of herpes simplex virus type 1 isolated from a patient with keratitis. (2171456)	Hidaka Y.... Mori R.	1990	GGCX
50	Cell mediated immunity in herpes simplex keratitis in man. (2275344)	Saini J.S.... Pradhan D.	1990	MIF

Genes related to keratitis according to GeneCards:

(show top 50)    (show all 115)

id	Symbol	Description	Score	GeneCards Section Context
1	PAX6	paired box 6	11.1	Aliases & Descriptions, Publications
2	TKT	transketolase	11.0	Publications
3	GJB2	gap junction protein, beta 2, 26kDa	11.0	Publications
4	CXCL2	chemokine (C-X-C motif) ligand 2	11.0	Publications
5	KERA	keratocan	11.0
6	JDP2	Jun dimerization protein 2	11.0	Publications
7	MFF	mitochondrial fission factor	11.0
8	DARC	Duffy blood group, chemokine receptor	11.0	Publications
9	FAM20C	family with sequence similarity 20, member C	11.0
10	AIM1	absent in melanoma 1	11.0
11	FAM13B	family with sequence similarity 13, member B	11.0
12	SRCIN1	SRC kinase signaling inhibitor 1	11.0
13	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
14	HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	11.0	Publications
15	HLA-DRA	major histocompatibility complex, class II, DR alpha	11.0	Publications
16	TLR9	toll-like receptor 9	11.0	Publications
17	DEFB4A	defensin, beta 4A	11.0	Publications
18	CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	11.0	Publications
19	COL9A1	collagen, type IX, alpha 1	11.0	Publications
20	CXCL9	chemokine (C-X-C motif) ligand 9	11.0
21	OXA1L	oxidase (cytochrome c) assembly 1-like	11.0	Publications
22	MBL2	mannose-binding lectin (protein C) 2, soluble	11.0	Publications
23	IL17A	interleukin 17A	11.0	Publications
24	TAT	tyrosine aminotransferase	11.0
25	CD44	CD44 molecule (Indian blood group)	11.0	Publications
26	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
27	GSR	glutathione reductase	11.0	Publications
28	NGF	nerve growth factor (beta polypeptide)	11.0	Publications
29	TLR2	toll-like receptor 2	11.0	Publications
30	TLR4	toll-like receptor 4	11.0	Publications
31	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
32	IFNA1	interferon, alpha 1	11.0	Publications
33	CST1	cystatin SN	10.9	Publications
34	ZNF692	zinc finger protein 692	10.9	Disorders
35	KRT6B	keratin 6B	10.9	Publications
36	GMPPB	GDP-mannose pyrophosphorylase B	10.9
37	KRT16	keratin 16	10.9	Publications
38	TLR8	toll-like receptor 8	10.9	Publications
39	TLR10	toll-like receptor 10	10.9	Publications
40	KRT3	keratin 3	10.9	Publications
41	GGCX	gamma-glutamyl carboxylase	10.9	Publications
42	MBD4	methyl-CpG binding domain protein 4	10.9	Publications
43	S100A12	S100 calcium binding protein A12	10.9	Publications
44	LCN1	lipocalin 1	10.9	Publications
45	ROBO4	roundabout, axon guidance receptor, homolog 4 (Drosophila)	10.9
46	MAP3K12	mitogen-activated protein kinase kinase kinase 12	10.9
47	T	T, brachyury homolog (mouse)	10.9
48	STAT2	signal transducer and activator of transcription 2, 113kDa	10.9	Publications
49	KRT17	keratin 17	10.9	Publications
50	TNFSF4	tumor necrosis factor (ligand) superfamily, member 4	10.9	Publications

Pathways related to keratitis according to GeneDecks:

(show top 50)    (show all 171)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.5	REL, RELA, MYD88, DEFB4A, TLR2, IL1RAP
2	RAR-Gamma-RXR-Alpha Degradation36	10.5	POLR2B, CCL20, CXCL1, CXCL2, CXCL9
3	Graft-versus-host disease20	10.2	HLA-DRA, FASLG, HLA-B, HLA-DPA1, IL1A
4	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	10.2	TLR8, CCL20, IL6, JUN, MYD88, REL
5	Th17 Differentiation37	10.1	CD4, IL17A, IL1B, IL1RAP, IL6, TLR10
6	Immune response_Bacterial infections in normal airways41	10.1	STAT1, DEFB4A, IL1RAP, IL1B, RELA, REL
7	Cytokine production by Th17 cells in CF (Mouse model)41	9.7	REL, IL17A, MYD88, IL6, IL8, NFKB1
8	Cytokine production by Th17 cells in CF41	9.6	NFKB1, ICAM1, IL8, IL17RA, MYD88, IL6
9	Transcription NF-kB signaling pathway10	9.5	IL1RAP, TLR4, NFKB1, TRB@, REL, RELA
10	Toll-Like Receptor Signaling Pathways37	9.3	IL18, JUN, MYD88, RELA, IL1B, IL6
11	Inflammasome Activation Pathways37	9.3	TLR9, TLR8, TLR4, TLR2, TLR10, NFKB1
12	Immune response_TLR signaling pathways41	9.3	TLR9, TLR8, TLR4, TLR2, NFKB1, CCL20
13	Th1 Differentiation37	9.1	HLA-DRA, TNF, TLR8, STAT5B, TLR2, TLR10
14	TREM1 Pathway36	8.9	TLR2, TLR4, TLR8, TLR9, TLR10, NFKB1
15	African trypanosomiasis20	8.8	MYD88, IL18, IL1B, IL6, FASLG, FAS
16	Measles20	8.7	STAT5B, STAT2, TLR9, IL6, TLR2, TLR4
17	NF-kappaB Signaling3	8.6	FAS, TLR4, TLR2, NFKB1, TNF, IL1B
18	ERK Signaling36	8.6	NFKB1, COL9A1, TNFSF4, CCL20, IL6, IL1A
19	Type I diabetes mellitus20	8.6	FASLG, HSPD1, IL1A, IL1B, FAS, HLA-B
20	TRAF Pathway36	8.5	TNF, IL1B, IL1A, MYD88, JUN, NFKB1
21	NOD-like receptor signaling pathway20	8.4	CXCL2, CXCL1, IL18, RELA, IL1B, IL6
22	Immune response MIF-mediated glucocorticoid regulation10	8.4	IL8, NFKB1, RELA, MIF, JUN, REL
23	Immune response_MIF-mediated glucocorticoid regulation41	8.4	NFKB1, TNF, ICAM1, JUN, IL8, IL6
24	Malaria20	8.4	ICAM1, CCL2, IL8, IL6, IL1B, IL18
25	Leishmaniasis20	8.4	TLR2, IL1A, TLR4, NFKB1, TNF, STAT1
26	MIF Mediated Glucocorticoid Regulation36	8.3	MIF, IL18, IL1A, IL1B, IL6, IL8
27	Cytokine Network36	8.3	IFNA2, IFNA1, IL8, IL6, IL1B, IL1A
28	Development_EGFR signaling pathway41	8.3	STAT1, HBEGF, REL, JUN, MMP2, MMP9
29	Immune response_MIF in innate immunity response41	8.3	IL6, MIF, TLR4, NFKB1, TNF, IL8
30	Immune response MIF in innate immunity response10	8.3	NFKB1, TNF, IL8, IL6, IL1B, MIF
31	PEDF Induced Signaling36	8.2	CCL2, IL6, IL1B, IL1A, IL18, CCL20
32	Tuberculosis20	8.1	IL6, IL1B, IL1A, IL18, CIITA, MYD88
33	STAT3 Pathway36	8.1	CXCL9, CCL20, TNF, TNFSF4, CXCL1, CXCL2
34	Toll-like receptor signaling pathway20	8.0	TLR4, TLR8, TLR9, STAT1, TLR2, CXCL9
35	all-trans-Retinoic Acid Signaling in Brain36	7.9	IL1B, IL1A, IL18, CXCL9, CXCL2, CXCL1
36	MIF Regulation of Innate Immune Cells36	7.9	CXCL9, CXCL2, CXCL1, TLR4, NFKB1, TNFSF4
37	Colorectal Cancer Metastasis36	7.9	EGF, STAT1, MMP2, IL6, TNF, NFKB1
38	NF-KappaB (p50-p65) Pathway36	7.9	TLR8, EGFR, TLR10, TLR9, EGF, IL1B
39	Immune response IL-1 signaling pathway10	7.9	IL8, IL1B, STAT1, IL1RAP, NFKB1, RELA
40	Immune response_IL-1 signaling pathway41	7.9	RELA, NFKB1, TNF, STAT1, IL1RAP, IL6
41	NF-KappaB Family Pathway36	7.8	FGF2, IL1A, IL1B, IL6, TNF, NFKB1
42	Chagas disease (American trypanosomiasis)20	7.7	IL8, FASLG, FAS, CCL2, IL6, IL1B
43	Pertussis20	7.7	JUN, MYD88, TLR4, RELA, IL1A, IL1B
44	Rheumatoid arthritis20	7.4	VEGFA, JUN, IL17A, IL18, IL1A, IL1B
45	JAK-STAT Pathway36	7.0	IFNA1, CCL2, IFNA2, CCL20, IL8, IL6
46	Influenza A20	6.8	RELA, MYD88, CIITA, JUN, IL18, IL1A
47	p38 Signaling36	6.8	IL1A, CXCL9, NFKB1, TNFSF4, IL1B, CXCL1
48	Tec Kinases Signaling36	6.6	STAT5B, STAT1, FGF2, CD4, MYD88, IL18
49	Antioxidant Action of Vitamin-C36	6.5	CXCL9, CXCL2, CCR6, EGFR, EGF, NFKB1
50	Cytokine-cytokine receptor interaction20	6.4	EGFR, CXCL1, CXCL2, CXCL9, VEGFA, IL8

Compounds related to keratitis according to GeneDecks:

(show top 50)    (show all 305)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	INF	REL, RELA, CIITA, , LCN1, S100A12
2	sp 60012532 42	11.8	IL17A, TLR2, DEFB4A, CXCL2
3	hcec32	10.7	IL6, NGF, HBEGF, TLR2, DEFB4A
4	cyclophosphamide32 34 9 9	13.5	MBL2, TRB@, LTF, CXCL9
5	endotoxin32	9.7	MYD88, CIITA, S100A8, MIF, IL18, FASLG
6	polyinosinic-polycytidylic acid32	9.6	CIITA, IL18, IL6, IL8, IFNA1, HLA-B
7	h2o232	9.6	ATF3, MMP8, MIF, IL18, IL2RA, ICAM1
8	histamine32 18	10.4	S100A8, GUSB, IL18, IL2RA, CCL2, IGHE
9	n acetylcysteine32	8.8	MMP2, MMP9, IL18, IL2RA, IGHE, HSPD1
10	polysaccharide32	8.8	CD69, CD4, FGF2, IL18, IL2RA, MBL2
11	groalpha32	8.8	IL17A, IL18, IL1A, IL1B, CCL2, ICAM1
12	pge232	8.6	CIITA, CD69, CD4, MMP8, GSR, FGF2
13	lipoteichoic acid32	8.5	MYD88, IL18, IL1B, IL6, IL8, MBL2
14	poly(i-c)32	8.4	CD69, IL18, IL1B, IL6, IL8, CCL20
15	oxygen32 18	9.4	PAX6, CIITA, LCN1, S100A8, ATF3, JUN
16	cysteine32	8.3	REL, VDR, S100A8, CD4, CD44, MMP2
17	imiquimod32 42 9 9	11.3	IL18, IL1A, IL6, IL8, FASLG, IFNA1
18	polymyxin b32	8.1	IL1A, IL1B, IL6, IL8, MBL2, CCL2
19	vegf32	8.1	PAX6, ATF3, MMP8, MMP9, MIF, FGF2
20	il 1032	8.0	VDR, IL18, IL1A, IL1B, IL2RA, IL6
21	tarc32	7.9	CD4, IL18, IL1A, IL8, CCR6, CCL2
22	alanine32	7.9	VDR, PAX6, CIITA, LCN1, S100A8, CD4
23	tetracycline32 9 9	9.9	S100A8, MMP2, MMP8, MMP9, MIF, GUSB
24	neopterin32	7.9	CD4, IL18, IL1A, IL1B, IL2RA, IL6
25	creatinine32	7.8	VDR, LCN1, S100A8, CD69, CD44, MMP2
26	mg 13232 42	8.7	VDR, JUN, IL1A, IL1B, IL8, FASLG
27	indomethacin32 9 9	9.5	GSR, IL17A, IL18, IL1A, IL1B, IL2RA
28	ccl332	7.5	MMP9, IL18, IL1A, IL1B, IL6, IL8
29	5fluorouracil32	7.4	VEGFA, VDR, ATF3, MMP2, IL18, IL2RA
30	rantes32	7.4	REL, MYD88, CIITA, JUN, CD4, CD44
31	testosterone32 9 18 9	10.0	RELA, VDR, ATF3, CD44, MMP2, MMP9
32	paraffin32	6.6	RELA, VEGFA, S100A8, CD44, MMP2, MMP9
33	curcumin32	6.1	VEGFA, JUN, MMP2, MMP9, MIF, IL17A
34	ly29400232	5.8	VEGFA, JUN, CD69, CD44, MMP2, MMP9
35	herbimycin a32 42	6.6	JUN, CD69, CD4, MMP2, MMP9, MIF
36	cyclosporin a32 42	6.5	REL, VDR, CIITA, JUN, CD69, CD44
37	pd 98,05932	5.3	JUN, CD69, MMP2, MMP9, FGF2, IL17A
38	actinomycin d32	5.2	VEGFA, VDR, CIITA, JUN, CD69, CD44
39	serine32	4.2	REL, RELA, VDR, MYD88, PAX6, CIITA
40	cycloheximide32	3.9	VEGFA, VDR, CIITA, JUN, CD69, CD4
41	dexamethasone32 42 34 9 9	INF	REL, VEGFA, VDR, BGN, CIITA,
42	thymidine32 18	INF	VDR, CIITA, JUN, CD69, CD44, MIF
43	phosphatidylinositol32	INF	MYD88, CIITA, , ATF3, JUN, CD69
44	nitric oxide32 9 18 9	INF	REL, MYD88, CIITA, S100A8, ATF3, CD69
45	lipid32	INF	MYD88, CIITA, LCN1, S100A8, CD69, CD4
46	tyrosine32	INF	REL, VEGFA, MYD88, CIITA, , S100A8
47	matrigel32	INF	VEGFA, , JUN, CD44, MMP2, MMP9
48	retinoic acid32 42 18	INF	REL, VDR, PAX6, S100A8, ATF3, JUN
49	calcitriol32 42 9 18 9	INF	VDR, S100A8, JUN, CD44, FGF2, IL2RA
50	estrogen32	INF	VDR, BMI1, , MMP2, MIF, GSR

Cellular components related to keratitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	membrane raft	GO:045121	8.6	EGFR, TNF, GJA1, CAV1, FAS, CD4
2	external side of plasma membrane	GO:009897	8.6	ROBO4, CXCL9, THBS1, TLR4, TLR2, TNF
3	cell surface	GO:009986	8.1	TNF, TNFSF4, PTPRJ, HBEGF, TLR2, CAV1
4	extracellular region	GO:005576	5.9	LTF, NGF, COL9A1, IFNA2, CCL20, CCL2
5	extracellular space	GO:005615	4.8	CXCL9, IFNA2, ICAM1, HSPD1, AIMP1, TNF
6	integral to plasma membrane	GO:005887	INF	HLA-DPA1, HLA-DRA, TNF, TNFSF4, PTPRJ, HBEGF

Biological processes related to keratitis according to GeneDecks:

(show top 50)    (show all 85)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of interleukin-12 production	GO:032735	10.6	HSPD1, TNFSF4, TLR2, TLR4, TLR9
2	positive regulation of nitric-oxide synthase biosynthetic process	GO:051770	10.6	TLR2, TLR4, CCL2, TLR9
3	positive regulation of inflammatory response	GO:050729	10.6	TLR4, TLR2, TNFSF4, IL18, STAT5B, TLR9
4	positive regulation of tumor necrosis factor production	GO:032760	10.5	MYD88, IL18, TLR2, TLR4, TLR9
5	defense response to bacterium	GO:042742	10.4	S100A12, HAMP, LTF, DEFB4A, CCL20, TLR9
6	positive regulation of interleukin-8 production	GO:032757	10.3	IL18, TLR2, IL1B, TLR4, TLR9
7	interferon-gamma-mediated signaling pathway	GO:060333	10.3	HLA-B, HLA-DRA, CIITA, ICAM1, CD44, STAT1
8	response to progesterone stimulus	GO:032570	10.3	TSPO, THBS1, TLR4, CAV1, CCL2
9	chemotaxis	GO:006935	10.2	CXCL9, CXCL2, CXCL1, DEFB4A, S100A8, CCL2
10	positive regulation of chemokine production	GO:032722	9.9	TLR2, TLR4, TLR9, TNF, IL6, IL18
11	positive regulation of interleukin-2 biosynthetic process	GO:045086	9.9	STAT5B, IL1B, IL1A, CD4
12	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.8	IL6, TLR4, MIF, CD44, CD4, VEGFA
13	cellular response to lipopolysaccharide	GO:071222	9.8	ICAM1, TLR4, IL8, TNFSF4, TSPO, CCL2
14	cellular response to mechanical stimulus	GO:071260	9.8	NFKB1, IL1B, FAS, MYD88, IL18, TLR8
15	cell-cell signaling	GO:007267	9.7	CCL20, IFNA2, IL1B, FASLG, IL18, IL17A
16	MyD88-dependent toll-like receptor signaling pathway	GO:002755	9.7	TLR10, RELA, TLR4, HSPD1, MYD88, JUN
17	defense response to Gram-positive bacterium	GO:050830	9.7	IL6, MYD88, MBL2, TLR2, TNF
18	positive regulation of NF-kappaB import into nucleus	GO:042346	9.7	IL1B, TNF, TLR2, TLR9, TLR4
19	response to radiation	GO:009314	9.6	MMP9, NGF, MBD4, IL18, JUN
20	toll-like receptor 1 signaling pathway	GO:034130	9.5	RELA, MYD88, JUN, NFKB1, TLR2, TLR4
21	positive regulation of gene expression	GO:010628	9.4	CD44, VEGFA, VDR, PAX6, IL18, GJA1
22	innate immune response	GO:045087	9.4	TLR10, TLR8, RELA, MBL2, CCR6, IFNA2
23	positive regulation of interferon-gamma production	GO:032729	9.4	TNFSF4, TNF, TLR4, IL18, HSPD1, IL1B
24	positive regulation of JNK cascade	GO:046330	9.3	IL1A, TLR9, MYD88, TLR4, TNF, IL1B
25	cell surface receptor signaling pathway	GO:007166	9.3	CCL2, IL2RA, MYD88, CD4, MIF, IL17RA
26	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.3	IL6, MIF, VEGFA, CAV1, TNF, CD44
27	negative regulation of growth of symbiont in host	GO:044130	9.3	MYD88, TLR2, TNF, MBL2
28	positive regulation of interleukin-6 production	GO:032755	9.2	TNFSF4, HSPD1, TLR4, TLR9, IL6, IL1B
29	positive regulation of smooth muscle cell proliferation	GO:048661	9.2	IL6, HBEGF, MYD88, JUN, TNF, STAT5B
30	lipopolysaccharide-mediated signaling pathway	GO:031663	9.2	TLR4, TNF, CCL2, IL1B, IL18, MYD88
31	cellular response to interleukin-1	GO:071347	9.2	NFKB1, ICAM1, CCL2, IL8, IL17A, MMP9
32	response to glucocorticoid stimulus	GO:051384	9.1	TAT, NGF, TNF, CAV1, CCL2, FAS
33	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.1	IL1B, IL1A, TLR4, TNF, CD44, MIF
34	positive regulation of nitric oxide biosynthetic process	GO:045429	9.1	IL1B, TLR4, TNF, TLR2, EGFR, ICAM1
35	cytokine-mediated signaling pathway	GO:019221	9.1	IL1B, IL6, STAT5B, STAT1, HLA-DRA, HLA-DPA1
36	response to lipopolysaccharide	GO:032496	9.1	IL1A, NGF, S100A8, JUN, FASLG, STAT5B
37	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.0	NFKB1, TLR4, TNF, TLR2, ICAM1, IL6
38	immune response	GO:006955	9.0	HAMP, CXCL9, CXCL2, CXCL1, IL1RAP, IL1A
39	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	8.9	GJA1, S100A12, IL1B, TLR9, REL, RELA
40	response to mechanical stimulus	GO:009612	8.7	JUN, CCL2, NGF, MMP9, CAV1, TNF
41	MAPK cascade	GO:000165	8.6	IL18, IL1B, EGFR, TNF, CAV1, CCL2
42	anti-apoptosis	GO:006916	8.4	THBS1, RELA, MYD88, NFKB1, IL1A, IL1B
43	angiogenesis	GO:001525	8.2	JUN, MMP2, VEGFA, ROBO4, CCL2, EGF
44	inflammatory response	GO:006954	7.7	IL17A, CCL20, IFNA2, AIMP1, TNF, DARC
45	negative regulation of cell proliferation	GO:008285	7.7	IL6, FGF2, JUN, VDR, IL1A, GJA1
46	response to drug	GO:042493	7.6	MMP9, THBS1, JUN, CCL2, FAS, TSPO
47	signal transduction	GO:007165	7.6	FAS, IL1B, FASLG, FGF2, CD4, IL8
48	response to hypoxia	GO:001666	7.5	MMP9, IL18, IL1A, IL1B, FAS, CCL2
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.1	JUN, TLR4, NFKB1, MYD88, PAX6, TLR2
50	organ morphogenesis	GO:009887	INF	, COL9A1, TNF, FGF2, PAX6, CCL2

Molecular functions related to keratitis according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:008009	9.9	CXCL9, CXCL2, CXCL1, CCL20, CCL2, IL8
2	receptor activity	GO:004872	9.8	ROBO4, TLR8, TLR4, TLR2, DARC, ICAM1
3	transmembrane signaling receptor activity	GO:004888	9.8	TLR4, TLR2, TLR10, EGFR, DARC, ICAM1
4	receptor binding	GO:005102	9.7	TNFSF4, HLA-B, GJA1, CAV1, CCL2, MBL2
5	cell surface binding	GO:043498	9.6	AIMP1, HSPD1, ICAM1, MIF, VEGFA
6	double-stranded DNA binding	GO:003690	9.1	STAT5B, STAT1, EGFR, NFKB1, JDP2, JUN
7	tumor necrosis factor receptor binding	GO:005164	9.0	STAT1, TNFSF4, TNF, FASLG
8	growth factor activity	GO:008083	8.8	CXCL1, HBEGF, EGF, NGF, IL6, IL1B
9	cytokine activity	GO:005125	7.8	FASLG, IFNA2, AIMP1, TNF, TNFSF4, CXCL9
10	protein binding	GO:005515	INF	GDI1, KRT16, NFKB1, SRCIN1, PTPRJ, TNF