MCID: KRT004
MIFTS: 60

Keratitis malady

Genetic diseases, Rare diseases, Eye diseases categories

Summaries for Keratitis

About this section


OMIM:45 Keratitis is a rare ocular disorder presenting with congenital and progressive features predominantly involving the... (148190) more...

MalaCards based summary: Keratitis, also known as hereditary keratitis, is related to vasculitis and rheumatoid arthritis, and has symptoms including autosomal dominant inheritance, keratitis and opacification of the corneal stroma. An important gene associated with Keratitis is PAX6 (paired box 6), and among its related pathways are Th17 Differentiation and IL-17 Family Signaling Pathways. The drugs tropicamide and loteprednol etabonate and the compounds ganciclovir and thymidine have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related mouse phenotypes are vision/eye and no phenotypic analysis.

Wikipedia:63 Keratitis is a condition in which the eye\'s cornea, the front part of the eye, becomes inflamed. The... more...

Aliases & Classifications for Keratitis

About this section
Sources:
45OMIM, 9Disease Ontology, 10diseasecard, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 22GTR, 60UMLS, 55SNOMED-CT, 38NCIt, 27ICD9CM, 33MeSH, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Keratitis, Aliases & Descriptions:

Name: Keratitis 45 9 10 11 43 60
Hereditary Keratitis 41 47 22
Autosomal Dominant Keratitis 41 47
 
Keratitis, Hereditary 41 60
Dominantly Inherited Keratitis 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Eye diseases
Orphanet: 47 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

47
hereditary keratitis:
Inheritance: Autosomal dominant; Age of onset: Childhood; Age of death: normal life expectancy


External Ids:

OMIM45 148190
Disease Ontology9 DOID:4677
NCIt38 C26805
ICD9CM27 370.9, 370
MeSH33 D007634
Orphanet47 2334
MESH via Orphanet34 C537022
ICD10 via Orphanet26 H16.8
UMLS via Orphanet61 C1835698
ICD1025 H16, H16.9

Related Diseases for Keratitis

About this section

Graphical network of the top 20 diseases related to Keratitis:



Diseases related to keratitis

Symptoms for Keratitis

About this section

Symptoms by clinical synopsis from OMIM:

148190

Clinical features from OMIM:

148190

HPO human phenotypes related to Keratitis:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 keratitis HP:0000491
3 opacification of the corneal stroma HP:0007759

Drugs & Therapeutics for Keratitis

About this section

Drug clinical trials:

Search ClinicalTrials for Keratitis

Search NIH Clinical Center for Keratitis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Keratitis

About this section

Genetic tests related to Keratitis:

id Genetic test Affiliating Genes
1 Keratitis, Hereditary22

Anatomical Context for Keratitis

About this section

MalaCards organs/tissues related to Keratitis:

31
Eye, T cells, Endothelial, Testes, Neutrophil, B cells, Lymph node, Retina, Liver, Skin, Bone marrow, Bone, Brain, Thyroid, Myeloid

Animal Models for Keratitis or affiliated genes

About this section

MGI Mouse Phenotypes related to Keratitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.8TKT, GJB2, PAX6, KERA
2MP:00030128.5GJB2, IL17RA, IL17A, MFF
3MP:00053977.8CCR6, IL17A, IL17RA, KERA, TNFSF4
4MP:00053767.2PAX6, GJB2, IL17RA, IL17A, AIMP1, CCR6
5MP:00053876.8IL17A, PAX6, CCR6, AIMP1, IL17RA, GJB2

Publications for Keratitis

About this section

Articles related to Keratitis:

(show top 50)    (show all 1956)
idTitleAuthorsYear
1
Treatment of keratitis-ichthyosis- deafness (KID) syndrome in children: a case report and review of the literature. (25546246)
2015
2
Femtosecond Laser-Assisted Anterior Lamellar Keratoplasty in Stromal Keratitis Caused by an Endoreticulatus-like Microsporidia. (25826328)
2015
3
I^I' T cells regulate the expression of cytokines but not the manifestation of fungal keratitis. (25864785)
2015
4
Trends in Microbiological and Antibiotic Sensitivity Patterns in Infectious Keratitis: 10-Year Experience in Mexico City. (25811724)
2015
5
Acanthamoeba keratitis: a new normal. (25012982)
2014
6
Alternaria keratitis and hypopyon after clear-cornea phacoemulsification. (24461506)
2014
7
Corneal collagen crosslinking and herpetic keratitis. (23889879)
2013
8
Actinomyces bowdenii ulcerative keratitis in a dog. (23121462)
2013
9
Recurrent non-tuberculous mycobacterial keratitis after deep anterior lamellar keratoplasty for keratoconus. (24136909)
2013
10
Acanthamoeba keratitis: study of the 5-year incidence in Israel. (23878134)
2013
11
Isolation and characterization of a new fungal genus and species, Aphanoascella galapagosensis, from carapace keratitis of a Galapagos tortoise (Chelonoidis nigra microphyes). (22852752)
2013
12
Severe ulcerative keratitis in ocular cowpox infection. (22932773)
2013
13
Herpes Simplex epithelial keratitis associated with daily disposable contact lens wear. (24333040)
2013
14
Inhibition of Ataxia Telangiectasia Mutated (ATM) Kinase Suppresses Herpes Simplex Virus Type 1 (HSV-1) Keratitis. (24370835)
2013
15
An unusual case of peripheral ulcerative keratitis as a presenting feature in an otherwise healthy patient with undiagnosed human immunodeficiency virus infection and low CD4 counts. (23514657)
2013
16
Modulation of immune signaling, bacterial clearance, and corneal integrity by toll-like receptors during streptococcus pneumoniae keratitis. (23841825)
2013
17
Therapeutic effect of deep anterior lamellar keratoplasty for active or quiescent herpetic stromal keratitis. (22349979)
2012
18
Chronic recalcitrant bacterial infection in steroid modified interstitial (stromal) keratitis: presentation and management. (23252209)
2012
19
A case of nocardia keratitis treated successfully with topical amikacin. (22344016)
2012
20
Bowman's layer encystment in cases of persistent Acanthamoeba keratitis. (22927735)
2012
21
Fungal keratitis caused by Chaetomium atrobrunneum. (22045390)
2012
22
Interstitial keratitis secondary to severe hidradenitis suppurativa responding to adalimumab. (22146546)
2012
23
Medical interventions for fungal keratitis. (22336802)
2012
24
Radial keratoneuritis as a presenting sign in acanthamoeba keratitis. (21887085)
2011
25
Interstitial keratitis secondary to severe hidradenitis suppurativa: a case report and literature review. (20628295)
2010
26
New-onset herpes simplex virus keratitis after cataract surgery. (19092420)
2009
27
Herpetic keratitis after descemet stripping automated endothelial keratoplasty for failed graft. (19125048)
2009
28
A rare connexin 26 mutation in a patient with a forme fruste of keratitis-ichthyosis-deafness (KID) syndrome. (19785089)
2009
29
Fusarium and Acanthamoeba keratitis: can a single centre detect outbreaks? (18441185)
2008
30
The application of in vivo confocal scanning laser microscopy in the management of Acanthamoeba keratitis. (17679934)
2007
31
Good visual outcome after prompt treatment of acanthamoeba keratitis associated with overnight orthokeratology lens wear. (17993830)
2007
32
Impression cytology in the diagnosis of acanthamoeba keratitis with surface involvement. (14962424)
2004
33
Bilateral deep keratitis caused by systemic lupus erythematosus. (15075893)
2004
34
Corneal epithelial cells and stromal keratocytes efficently produce CC chemokine-ligand 20 (CCL20) and attract cells expressing its receptor CCR6 in mouse herpetic stromal keratitis. (15287366)
2004
35
Non-contact lens related Acanthamoeba keratitis at a tertiary eye care center in south India: Implications for eye care programs in the region. (12709670)
2003
36
Persistence of acanthamoeba antigen following acanthamoeba keratitis. (11222330)
2001
37
Classification of herpes simplex virus keratitis and anterior uveitis. (10090358)
1999
38
Acanthamoeba keratitis and contact lens wear. (9371196)
1997
39
Keratitis, ichthyosis, and deafness (KID syndrome): review of the literature and proposal of a new terminology. (9122065)
1996
40
Acinetobacter exposure keratitis. (8060938)
1994
41
Murine herpes simplex virus keratitis is accentuated by CD4+, V beta 8.2+ Th2 T cells. (7908153)
1993
42
Acanthamoeba keratitis: experience in a non-specialist microbiology laboratory. (1890209)
1991
43
Filamentary keratitis--the clinical challenges. (1813523)
1991
44
Recurrent herpetic keratitis: failure to detect herpes simplex virus infection using the Syva MicroTrak HSV1/HSV2 direct specimen identification/typing test. (1963928)
1990
45
Immunobiology of Langerhans cells on the ocular surface. II. Role of central corneal Langerhans cells in stromal keratitis following experimental HSV-1 infection in mice. (2561960)
1989
46
Management of herpetic keratitis. (7046194)
1982
47
HLA antigens in recurrent stromal herpes simplex virus keratitis. (7356786)
1980
48
Management of resistant cases of herpetic keratitis using cryo-immunotherapy technique. (1031073)
1976
49
Some aspects of interstitial keratitis. (15410175)
1950
50
Eczematous keratitis and ariboflavinosis. (18103821)
1948

Variations for Keratitis

About this section

Expression for genes affiliated with Keratitis

About this section
Search GEO for disease gene expression data for Keratitis.

Pathways for genes affiliated with Keratitis

About this section

Compounds for genes affiliated with Keratitis

About this section
Sources:
43Novoseek, 12DrugBank, 24HMDB, 28IUPHAR
See all sources

Compounds related to Keratitis according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1ganciclovir43 1210.5GJB2, TKT
2thymidine43 2410.4IL17A, GJB2, TKT
3ccl443 2810.2IL17A, CCR6
4rantes438.8CCR6, IL17A, IL17RA
5vegf438.7TKT, IL17A, CCR6, PAX6

GO Terms for genes affiliated with Keratitis

About this section

Cellular components related to Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:00057779.5TKT, MFF

Biological processes related to Keratitis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cornea development in camera-type eyeGO:00613039.8PAX6, KERA
2fibroblast activationGO:00725379.7IL17A, IL17RA
3response to woundingGO:00096119.7AIMP1, PAX6
4positive regulation of interleukin-23 productionGO:00327479.7IL17RA, IL17A
5positive regulation of cytokine production involved in inflammatory responseGO:019000179.6IL17RA, IL17A
6cell-cell signalingGO:00072679.2AIMP1, IL17A, GJB2
7immune responseGO:00069558.5CCR6, TNFSF4, IL17A

Molecular functions related to Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.1IL17A, TNFSF4, AIMP1

Products for genes affiliated with Keratitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Keratitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet