MCID: KRT005
MIFTS: 51

Keratoacanthoma malady

Genetic diseases, Cancer diseases, Eye diseases, Skin diseases, Rare diseases categories

Summaries for Keratoacanthoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) skin tumour that is... more...

MalaCards: Keratoacanthoma is related to muir-torre syndrome and lichen planus. An important gene associated with Keratoacanthoma is KRT10 (keratin 10), and among its related pathways are Granzyme Pathway and Telomere C-strand (Lagging Strand) Synthesis. The compounds isotretinoin and tcdd have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and bone, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Keratoacanthoma

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9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:



Aliases & Descriptions:

keratoacanthoma 9 46 63


External Ids:

Disease Ontology9 DOID:3149
NCIt41 C3146
MeSH36 D007636

Related Diseases for Keratoacanthoma

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18GeneCards, 19GeneDecks
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Diseases in the Familial Keratoacanthoma family:

keratoacanthoma

Diseases related to Keratoacanthoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1muir-torre syndrome30.6MLH1, MSH2
2lichen planus30.5GZMB, KRT10
3basal cell carcinoma30.4MKI67, MMP13, GZMB, KRT17, KRT10
4papilloma30.3KRT10
5melanoma30.2MLH1, MKI67, MMP13, MSH2, NME1, GZMB
6psoriasis30.2GZMB, KRT17, KRT10
7cervical squamous cell carcinoma30.1KRT10, MKI67, MLH1
8steatocystoma multiplex30.0KRT17, KRT10
9sarcoma29.7MSH2, MKI67, MLH1
10adenocarcinoma29.7MLH1, MKI67, MMP13, MSH2, NME1, KRT17
11transitional cell carcinoma29.7NME1, MSH2, MKI67, MLH1
12leukemia29.7MLH1, MSH2, NME1, GZMB, KRT10
13keratosis10.3
14lupus erythematosus10.3
15familial keratoacanthoma10.2
16discoid lupus erythematosus10.2
17actinic keratosis10.1
18turcot syndrome10.1MLH1
19palmoplantar keratosis10.1KRT17, KRT10
20epidermolysis bullosa simplex10.1KRT10, KRT17
21sebaceous adenoma10.1MSH2
22peripheral t-cell lymphoma10.1GZMB, NME1
23vulvar keratoacanthoma-like carcinoma10.0
24cutaneous lupus erythematosus10.0
25sporotrichosis10.0
26cervicitis10.0
27epidermal nevus10.0
28multiple self-healing squamous epithelioma, susceptiblity to10.0
29endometrial carcinoma10.0NME1, MLH1
30breast cancer, invasive ductal10.0MKI67, NME1
31leukoplakia10.0NME1, MKI67
32smooth muscle tumor10.0MKI67, NME1
33breast fibroadenoma10.0MKI67, NME1
34tongue squamous cell carcinoma10.0MKI67, NME1
35bladder carcinoma10.0KRT10, MKI67
36laryngeal benign neoplasm10.0MKI67, NME1
37bowen syndrome10.0MKI67, KRT17, KRT10
38familial colorectal cancer10.0MSH2, MLH1
39esophageal cancer10.0MMP13, NME1
40lynch syndrome10.0MLH1, MSH2
41synovial sarcoma10.0MMP13, MKI67
42rectal neoplasm10.0MSH2, MLH1
43gastric adenocarcinoma10.0NME1, MMP13, MLH1
44squamous cell carcinoma of the head and neck10.0MLH1, MMP13, NME1
45gallbladder cancer10.0NME1, MKI67, MLH1
46malignant fibroxanthoma10.0MSH2, MKI67
47laryngeal squamous cell carcinoma10.0NME1, MMP13, MKI67
48cervical cancer10.0MMP13, NME1, GZMB, KRT10
49stomach cancer10.0MLH1, MKI67, NME1
50retinoblastoma10.0KRT10, NME1, MKI67

Graphical network of the top 20 diseases related to Keratoacanthoma:



Diseases related to keratoacanthoma

Symptoms for Keratoacanthoma

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Drugs & Therapeutics for Keratoacanthoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Keratoacanthoma

Drug clinical trials:

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Search NIH Clinical Center for Keratoacanthoma

Search CenterWatch for Keratoacanthoma

Genetic Tests for Keratoacanthoma

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Anatomical Context for Keratoacanthoma

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34MalaCards
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MalaCards organs/tissues related to Keratoacanthoma:

34
Skin, Lung, Bone, Colon, Myeloid, Cervix, Testes, Bone marrow, Smooth muscle, Lymph node, Tongue

Animal Models for Keratoacanthoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Keratoacanthoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9MLH1, MSH2, NME1, GZMB, KRT10
2MP:00053847.8KRT17, GZMB, MSH2, MMP13, MLH1
3MP:00107717.4KRT10, KRT17, NME1, MSH2, MMP13, MLH1
4MP:00107687.2MLH1, MSH2, NME1, GZMB, KRT17, KRT10

Publications for Keratoacanthoma

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53PubMed
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Articles related to Keratoacanthoma:

(show top 50)    (show all 516)
idTitleAuthorsYear
1
Keratoacanthoma with secondary ossification. (23231325)
2014
2
Two rare variants of keratoacanthoma in the same sign-out session. (24117878)
2013
3
Keratoacanthoma: an unusual nasal mass. (24376301)
2013
4
Spontaneous involution of keratoacanthoma, iconographic documentation and similarity with volcanoes of nature. (22570051)
2012
5
The nuclear factor kappa B p50 subunit and cortactin as markers to distinguish between keratoacanthoma and well-differentiated squamous cell carcinoma. (21883393)
2011
6
Keratoacanthoma of the head and neck with perineural invasion: incidental finding or cause for concern? (20653733)
2010
7
Issues with keratoacanthoma, pseudoepitheliomatous hyperplasia and squamous cell carcinoma within tattoos: a clinical point of view. (19614733)
2010
8
Cutaneous lupus erythematosus mimicking multiple keratoacanthomas. (19106056)
2009
9
Keratoacanthoma in a tattoo. (19903437)
2009
10
PGP 9.5 expression in cutaneous keratoacanthomas and squamous cell carcinomas. (19488775)
2009
11
Benign fibrous histiocytoma of the eyelid mimicking keratoacanthoma. (17237703)
2007
12
A case of multiple keratoacanthomas associated with keratoacanthoma centrifugum marginatum. (16648927)
2006
13
HPV 6-positive giant keratoacanthoma in an immunocompetent patient. (16683389)
2006
14
Intralesional methotrexate for keratoacanthoma of the nose. (16276163)
2005
15
Imiquimod as a possible treatment for keratoacanthoma. (14964750)
2004
16
Multiple, keratoacanthoma-like nodules on a 47-year-old man: a rare presentation of cutaneous lupus erythematosus. (14636190)
2003
17
Keratoacanthoma developing on a pigmented patch in incontinentia pigmenti. (10828638)
2000
18
Malignant changes in a giant orbital keratoacanthoma developing over 25 years. (10794263)
2000
19
Multiple keratoacanthoma with neonatal onset in a girl. (10627223)
1999
20
Persistent keratoacanthoma: challenges in management. (9865205)
1998
21
Cutaneous sporotrichosis presenting as a keratoacanthoma. (9675531)
1998
22
Keratoacanthoma: is it a real entity? (9600429)
1998
23
Keratoacanthomas and lymphomatoid papulosis. (9700388)
1998
24
Generalized eruptive keratoacanthoma of Grzybowski: response to cyclophosphamide. (9146546)
1997
25
The paradoxical association of regression with a poor prognosis in melanoma contrasted with a good prognosis in keratoacanthoma. (8640780)
1996
26
Solitary intraoral keratoacanthoma: report of a case. (8765395)
1996
27
Microsatellite instability in keratoacanthoma. (8625045)
1995
28
Keratoacanthoma versus squamous cell carcinoma. An immunohistochemical reappraisal of p53 protein and proliferating cell nuclear antigen expression in keratoacanthoma-like tumors. (8600793)
1995
29
Subungual keratoacanthoma masquerading as a chronic paronychia. (7702309)
1995
30
Eruptive skin tags and keratoacanthomas in a patient with prolactinoma and colonic polyposis. (8075462)
1994
31
Nature of keratoacanthoma. (7943646)
1994
32
Basal cell carcinoma and keratoacanthoma in Hawaiians: an incidence report. (8227552)
1993
33
Generalized eruptive keratoacanthoma of Grzybowski. (8340502)
1993
34
DNA image cytometry of keratoacanthoma and squamous cell carcinoma. (1875048)
1991
35
Keratoacanthoma versus squamous cell carcinoma of the lower lip. (2189352)
1990
36
Keratoacanthoma of the limbus. (3362498)
1988
37
Intralesional 5-fluorouracil for keratoacanthoma of the eyelid. (3154563)
1986
38
Is it skin cancer--or keratoacanthoma? (6468938)
1984
39
Keratoacanthoma. A clinical study. (6721538)
1984
40
Treatment of keratoacanthoma with intralesional bleomycin. (6194810)
1983
41
Squamous-cell carcinoma vs. keratoacanthoma. (7096765)
1982
42
Hypocomplementemia in keratoacanthoma. (7247456)
1981
43
Keratoacanthoma of the head and neck. (7356269)
1980
44
Successful treatment of keratoacanthoma with intralesional fluorouracil. (7364978)
1980
45
Immune response to human keratoacanthoma. (394758)
1979
46
Conservative treatment of keratoacanthoma. (543623)
1979
47
Giant keratoacanthoma of the ear. (595076)
1977
48
Keratoacanthoma of the lower lip. Review of the literature and report of a case. (4531621)
1974
49
Epidermal antigens in experimental keratoacanthoma and squamous cell carcinoma. (4579775)
1973
50
Keratoacanthoma of nailbed: a report of two cases. (4704160)
1973

Variations for Keratoacanthoma

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Expression for genes affiliated with Keratoacanthoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratoacanthoma

Search GEO for disease gene expression data for Keratoacanthoma.

Pathways for genes affiliated with Keratoacanthoma

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51PathCards, 54QIAGEN, 56Reactome, 61Thomson Reuters, 39NCBI BioSystems Database, 31KEGG, 52PharmGKB, 5Cell Signaling Technology
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Compounds for genes affiliated with Keratoacanthoma

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46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 25HMDB
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Compounds related to Keratoacanthoma according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1isotretinoin46 1210.7MKI67, KRT10
2tcdd469.7MMP13, KRT10
3dutp469.6MKI67, KRT10
4p00001469.5MKI67, MLH1
5n-methyl-n-nitrosourea469.5MLH1, MSH2
6retinoid469.5KRT10, KRT17, MMP13
7glyceraldehyde 3-phosphate469.5KRT10, NME1, MMP13
8mononucleotide469.5MLH1, MSH2
96 thioguanine469.5MLH1, MSH2
10mnng469.4MLH1, MSH2
11agarose469.4MLH1, MMP13, GZMB
12temozolomide46 1210.4MSH2, MLH1
13hematoxylin469.4MKI67, KRT10
14etoposide46 52 62 1212.4MLH1, NME1, GZMB
15ribonucleic acid469.4GZMB, NME1, MMP13
16bromodeoxyuridine469.4KRT10, MKI67, MLH1
17o6-methylguanine469.4MLH1, MSH2
18chi 2469.3MLH1, MKI67, NME1
19carboplatin46 52 1211.1MSH2, MLH1
20dexamethasone46 52 30 1212.1MMP13, NME1, GZMB, KRT10
21crcs469.1NME1, MSH2, MLH1
22oligonucleotide469.1KRT17, GZMB, NME1, MMP13
23irinotecan46 52 1211.0MKI67, MLH1
24lactate469.0GZMB, NME1, MKI67
25fatty acid468.9MLH1, MKI67, NME1, KRT10
26progesterone46 30 62 25 1212.9KRT10, NME1, MKI67, MLH1
27thymidylate468.9MSH2, MKI67, MLH1
28nitric oxide46 25 1210.8GZMB, NME1, MMP13, MKI67
29p002468.8NME1, MMP13, MKI67, MLH1
30thymidine46 259.7MLH1, MKI67, MMP13, NME1
31doxorubicin46 52 1210.7MSH2, MKI67, MLH1
32oxygen46 259.6MLH1, MKI67, MMP13, GZMB
33alanine468.6MLH1, MSH2, NME1, GZMB
34steroid468.6KRT10, GZMB, NME1, MKI67, MLH1
35proline468.6KRT10, MSH2, MKI67, MLH1
36biotin46 25 1210.5MLH1, MKI67, MSH2, NME1
375fluorouracil468.5MLH1, MKI67, MSH2, NME1
38vegf468.4MLH1, MKI67, MMP13, NME1, GZMB
39atp46 309.3MLH1, MSH2, NME1, GZMB, KRT17
40arginine468.2KRT10, GZMB, MSH2, MKI67, MLH1
41cisplatin46 52 62 1211.1MLH1, MKI67, MSH2, NME1, GZMB
42estrogen468.1MLH1, MKI67, MMP13, NME1, GZMB, KRT10
43calcium46 52 25 1211.0MLH1, MKI67, MMP13, NME1, GZMB, KRT10
44retinoic acid46 258.7MLH1, MKI67, MMP13, NME1, GZMB, KRT17
45tyrosine467.7MLH1, MKI67, MMP13, NME1, GZMB, KRT17
46serine467.4MKI67, MMP13, MSH2, NME1, GZMB, KRT17
47paraffin466.8KRT10, MLH1, MKI67, MMP13, MSH2, NME1

GO Terms for genes affiliated with Keratoacanthoma

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17Gene Ontology
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Cellular components related to Keratoacanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.7KRT10, KRT17

Biological processes related to Keratoacanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:0062989.1MSH2, MLH1
2somatic hypermutation of immunoglobulin genesGO:0164469.0MSH2, MLH1
3isotype switchingGO:0451908.8MSH2, MLH1

Molecular functions related to Keratoacanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1guanine/thymine mispair bindingGO:0321378.8MSH2, MLH1
2single-stranded DNA bindingGO:0036978.6NME1, MSH2, MLH1
3ATP bindingGO:0055248.1NME1, MSH2, MKI67, MLH1

Products for genes affiliated with Keratoacanthoma

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Sources for Keratoacanthoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet