MCID: KRT005
MIFTS: 47

Keratoacanthoma malady

Summaries for Keratoacanthoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) skin tumour that is... more...

MalaCards: Keratoacanthoma is related to squamous cell carcinoma and muir-torre syndrome. An important gene associated with Keratoacanthoma is KRT10 (keratin 10), and among its related pathways are Lagging Strand Synthesis and Degradation of the extracellular matrix. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and integument.

Aliases & Classifications for Keratoacanthoma

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

keratoacanthoma 8 45 61


External Ids:

Disease Ontology8 DOID:3149
NCIt40 C3146
MeSH35 D007636

Related Diseases for Keratoacanthoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the familial keratoacanthoma family:

keratoacanthoma

Diseases related to Keratoacanthoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.3CRABP1, MKI67, MMP10, MMP19, NME1
2muir-torre syndrome30.6MLH1, MSH2
3basal cell carcinoma30.5KRT17, KRT10, KRT16, MMP13, MKI67, BAK1
4lichen planus30.4GZMB, IVL, DSG3, KRT16, KRT10
5adenocarcinoma30.0IVL, MLH1, AREG, DSG3, BAK1, MSH2
6steatocystoma multiplex29.8KRT17, KRT10, KRT16
7arthritis29.8GZMB, MMP13, MMP10
8bladder carcinoma29.8AREG, MKI67, CDKN1A, PCNA
9transitional cell carcinoma29.8MLH1, MKI67, CDKN1A, PCNA, NME1, MSH2
10skin squamous cell carcinoma10.5
11familial keratoacanthoma10.3
12verrucous carcinoma10.2
13anal squamous cell carcinoma10.2
14discoid lupus erythematosus10.2
15squamous cell papilloma10.1
16eye carcinoma10.1
17actinic keratosis10.1
18eyelid carcinoma10.1
19n syndrome10.1
20basal cell carcinoma, multiple10.1
21cutaneous lupus erythematosus10.0
22vulvar keratoacanthoma-like carcinoma10.0
23sporotrichosis10.0
24vitiligo10.0
25epidermal nevus10.0
26multiple self-healing squamous epithelioma, susceptiblity to10.0
27skin melanoma10.0NME1
28gingivitis10.0MMP13
29hepatitis10.0GZMB
30gallbladder cancer10.0MLH1
31severe combined immunodeficiency10.0CD3D
32tongue cancer10.0CDKN1A
33malignant mesothelioma10.0AREG
34gastrointestinal stromal tumor10.0PCNA, MKI67
35neuroblastoma10.0NME1
36wilms tumor10.0AREG
37deficiency anemia10.0AREG
38sebaceous adenoma10.0MSH2
39epidermolytic hyperkeratosis10.0KRT16, KRT10
40teratocarcinoma10.0CRABP1
41gastritis10.0PCNA, AREG
42monilethrix10.0KRT17, KRT16
43keratosis10.0IVL, KRT16, KRT10
44cystadenocarcinoma10.0AREG
45li-fraumeni syndrome10.0CDKN1A, MLH1
46cholesteatoma10.0KRT10, KRT16, IVL
47oral cancer10.0IVL, CDKN1A, PCNA
48leiomyoma10.0PCNA, MKI67, IVL
49thyroid cancer10.0CDKN1A
50pituitary adenoma10.0PCNA, MKI67

Graphical network of the top 20 diseases related to Keratoacanthoma:



Diseases related to keratoacanthoma

Clinical Features for Keratoacanthoma

Drugs & Therapeutics for Keratoacanthoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Keratoacanthoma

Drug clinical trials:

Search ClinicalTrials for Keratoacanthoma

Search NIH Clinical Center for Keratoacanthoma

Search CenterWatch for Keratoacanthoma

Genetic Tests for Keratoacanthoma

Anatomical Context for Keratoacanthoma

Animal Models for Keratoacanthoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Keratoacanthoma

Sources:
51PubMed
See all sources

Articles related to Keratoacanthoma:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Two rare variants of keratoacanthoma in the same sign-out session. (24117878)
2013
2
Use of double-bladed biopsy in distinguishing keratoacanthoma from squamous cell carcinoma-a case report. (23785638)
2013
3
Spontaneous involution of keratoacanthoma, iconographic documentation and similarity with volcanoes of nature. (22570051)
2012
4
Use of proliferation rate, p53 staining and perforating elastic fibers in distinguishing keratoacanthoma from hypertrophic lichen planus: a pilot study. (22236162)
2012
5
Clinical manifestations of cutaneous metastases: a review with special emphasis on cutaneous metastases mimicking keratoacanthoma. (22229935)
2012
6
Keratoacanthoma in a tattoo. (19903437)
2009
7
Keratoacanthoma with perineural invasion: an indicator for aggressive behavior? (18445070)
2008
8
Apoptotic markers in the differential diagnosis of keratoacanthoma versus squamous cell carcinoma. (17222261)
2007
9
A rapidly growing squamous cell carcinoma or keratoacanthoma or both? (17721662)
2007
10
Keratoacanthoma developing on nevus sebaceous in a child. (17224391)
2007
11
Beta-catenin and CD44 expression in keratoacanthoma and squamous cell carcinoma of the skin. (17679465)
2007
12
A case of multiple keratoacanthomas associated with keratoacanthoma centrifugum marginatum. (16648927)
2006
13
Giant keratoacanthoma of the hand. (16444311)
2005
14
Identification of Muir-Torre syndrome among patients with sebaceous tumors and keratoacanthomas: role of clinical features, microsatellite instability, and immunohistochemistry. (15662714)
2005
15
Imiquimod as a possible treatment for keratoacanthoma. (14964750)
2004
16
Primary cutaneous CD30 anaplastic large cell lymphoma with keratoacanthoma-like pseudocarcinomatous hyperplasia and marked eosinophilia and neutrophilia. (15186435)
2004
17
Keratoacanthoma observed. (15308394)
2004
18
Pancytopenia after treatment of keratoacanthoma by single lesional methotrexate infiltration. (11493112)
2001
19
Keratoacanthoma in the differential diagnosis of anal carcinoma: difficult diagnosis, easy therapy. Report of three cases. (10733129)
2000
20
Analysis of microsatellite instability and loss of heterozygosity in keratoacanthoma. (9143733)
1997
21
Proliferating cell nuclear antigen (PCNA) expression in pseudoepitheliomatous hyperplasia, keratoacanthoma and squamous cell carcinoma of the skin. (8893923)
1996
22
Trisomy 7 in keratoacanthoma and squamous cell carcinoma detected by fluorescence in-situ hybridization. (8835173)
1995
23
Is keratoacanthoma a variant of squamous cell carcinoma. New insights into an old controversy ... soon? (8600791)
1995
24
Dowling-Degos disease, hidradenitis suppurativa, and multiple keratoacanthomas. A disorder that may be caused by a single underlying defect in pilosebaceous epithelial proliferation. (2050858)
1991
25
Giant keratoacanthoma: an atypical presentation. (2122381)
1990
26
Suspected keratoacanthoma--a wolf in sheep's clothing? (2235857)
1990
27
Subungual keratoacanthoma: possible relationship to exposure to steel wool. (2200649)
1990
28
Keratoacanthoma necessitating metacarpal amputation. (2269796)
1990
29
Non-immunologic enhancement and regression of self-healing squamous cell carcinoma (keratoacanthoma)--ground substance and inflammation. (3412200)
1988
30
Quantitation of S100 protein-positive cells in inflamed and non-inflamed keratoacanthoma and squamous cell carcinoma. (3372786)
1988
31
Management of subungual keratoacanthoma. (3760501)
1986
32
Immunological findings during treatment of multiple keratoacanthoma with etretinate. (3484632)
1986
33
Large periocular keratoacanthoma: the case for definitive treatment. (3774277)
1986
34
Surgical treatment for aggressive giant keratoacanthoma of the face. (3950181)
1986
35
Chromoblastomycosis can mimic keratoacanthoma. (3759313)
1986
36
Keratoacanthoma centrifugum marginatum versus low-grade squamous cell carcinoma. (4007216)
1985
37
Metastasizing keratoacanthoma vs. squamous cell carcinoma. (4091226)
1985
38
Keratoacanthoma in a black patient. (6725736)
1984
39
The basal lamina in basal cell carcinoma, Bowen's disease, squamous cell carcinoma and keratoacanthoma: an immunoperoxidase study using an antibody to type IV collagen. (6371685)
1984
40
Polyarthritis with atypical keratotic nodular dermatosis or polyarthritis with multiple keratoacanthoma. A case report. (6209172)
1984
41
The use of podophyllin in the treatment of keratoacanthoma. (6629612)
1983
42
Differentiating keratoacanthoma from squamous cell carcinoma of the lower lip: an analysis of intraepithelial elastic fibers and intracytoplasmic glycogen. (6580597)
1983
43
Hypocomplementemia in keratoacanthoma. (7247456)
1981
44
Subungual keratoacanthoma. (7258561)
1980
45
Aggressive histological features of keratoacanthoma. (753852)
1977
46
Solitary intraoral keratoacanthoma. (264336)
1977
47
Solitary keratoacanthoma of the nipple in a male. Case report. (1002877)
1976
48
Squamous cell carcinoma vs. keratoacanthoma: criteria for histologic differentiation. (1088887)
1975
49
Intracutaneous cornifying epithelioma (keratoacanthoma) in the dog: a retrospective study of 25 cases. (1158776)
1975
50
Solitary intraoral keratoacanthoma. (4524889)
1974

Genetic Variations for Keratoacanthoma

Expression for genes affiliated with Keratoacanthoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Keratoacanthoma

Search GEO for disease gene expression data for Keratoacanthoma.

Pathways for genes affiliated with Keratoacanthoma

Sources:
54Reactome, 38NCBI BioSystems Database, 52QIAGEN, 30KEGG, 12EMD Millipore, 4Cell Signaling Technology
See all sources

Pathways related to Keratoacanthoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3MSH2, MLH1
2
Hide members
10.2MMP19, MMP10, MMP13
3
Hide members
10.2MMP19, MMP10, MMP13
4
Cell adhesion ECM remodeling
Hide members
10.2MMP13, MMP10, MMP19
5
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
10.2MLH1, PCNA, MSH2
6
Hide members
10.1PCNA, CDKN1A, MLH1, MSH2
710.0BAK1, MSH2, PCNA, CDKN1A, MLH1
8
Hide members
10.0PCNA, CDKN1A, MKI67, MLH1, MSH2
9
Hide members
10.0PCNA, CDKN1A, DSG3, GZMB, BAK1
10
Hide members
9.9MMP19, MMP10, MMP13, CD3D, CDKN1A, AREG

Compounds for genes affiliated with Keratoacanthoma

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 24HMDB
See all sources

Compounds related to Keratoacanthoma according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8IVL
2cycloheximide4510.6CRABP2
3etoposide45 50 60 1113.6BAK1, MLH1, GZMB
4dithranol4510.5IVL, KRT10, KRT16
5chi 24510.5NME1, MKI67, MLH1
6calcipotriol45 60 29 1113.5KRT10, KRT16, IVL
7temozolomide45 1111.5MLH1, CDKN1A, MSH2, PCNA
8gm 60016010.5MMP13, MMP19, MMP10
9mnng4510.5MSH2, PCNA, MLH1
10acitretin45 1111.5KRT17, IVL, CRABP1
11uk 3833676010.5MMP13, MMP10, MMP19
12gi 254023x6010.5MMP13, MMP10, MMP19
13isotretinoin45 1111.5KRT10, MKI67, CRABP1, KRT16
14sodium dodecylsulfate4510.4KRT17, KRT16, IVL, CRABP2
15dutp4510.4PCNA, KRT10, MKI67, BAK1
16o6-methylguanine4510.4MSH2, MLH1, PCNA
17hematoxylin4510.4MKI67, KRT10, PCNA, IVL
18irinotecan45 50 1112.4CDKN1A, MLH1, BAK1, MKI67
19celecoxib45 60 29 50 11 2415.4MKI67, BAK1, CDKN1A, PCNA
20biotin45 11 2412.4MSH2, MLH1, MKI67, PCNA, NME1
21thymidylate4510.4MKI67, MLH1, CDKN1A, PCNA, MSH2
22paclitaxel45 50 1112.3MLH1, BAK1, CDKN1A
23steroid4510.3CRABP2, MKI67, NME1, KRT16, KRT10, GZMB
24p0024510.3MLH1, MKI67, MMP13, NME1
25marimastat45 60 1112.3MMP10, MMP19, MMP13
26gf 109203x45 6011.3IVL, CDKN1A, KRT10, MMP13
27bromodeoxyuridine4510.3MLH1, IVL, MKI67, CDKN1A, PCNA, KRT10
28dexamethasone45 50 29 1113.3NME1, PCNA, BAK1, MMP13, AREG, GZMB
29fatty acid4510.3CRABP2, MLH1, IVL, NME1, KRT10, CRABP1
30calcitriol45 60 11 2413.2KRT16, BAK1, KRT10, NME1, CDKN1A, AREG
3112-o-tetradecanoylphorbol 13-acetate4510.2MMP10, GZMB, AREG, MMP13, CDKN1A, BAK1
32agarose4510.1MLH1, CDKN1A, GZMB, MMP13
33progesterone45 60 29 11 2414.1MLH1, MKI67, CDKN1A, PCNA, KRT10, AREG
34crcs4510.1MSH2, MLH1, NME1
355fluorouracil4510.1MKI67, MSH2, BAK1, IVL, CDKN1A, PCNA
36thymidine45 2411.1PCNA, MMP13, MKI67, IVL, MLH1, AREG
37proline4510.1CRABP1, MSH2, CRABP2, MLH1, MKI67, KRT16
38camptothecin45 60 1112.1PCNA, BAK1, CDKN1A, MLH1
39oxygen45 2411.0BAK1, MKI67, CDKN1A, MMP13, IVL
40oligonucleotide4510.0GZMB, IVL, CDKN1A, PCNA, MMP10, NME1
41arginine4510.0MKI67, MLH1, CRABP2, PCNA, KRT10, CRABP1
42cisplatin45 50 60 1113.0GZMB, MSH2, NME1, PCNA, CDKN1A, MLH1
43retinoid4510.0IVL, CRABP2, MMP13, CDKN1A, KRT16, KRT10
44serine4510.0NME1, MMP10, MMP13, MKI67, DSG3, KRT17
45vegf459.9IVL, PCNA, MLH1, AREG, GZMB, MKI67
46calcium45 50 11 2412.8IVL, AREG, KRT10, DSG3, CRABP1, GZMB
47tyrosine459.8KRT17, NME1, MMP13, CDKN1A, MKI67, BAK1
48paraffin459.7MSH2, MMP13, NME1, KRT16, KRT10, KRT17
49doxorubicin45 50 1111.7BAK1, CDKN1A, MLH1, MKI67, MSH2
50retinoic acid45 2410.4MKI67, BAK1, MLH1, CRABP2, CRABP1, AREG

GO Terms for genes affiliated with Keratoacanthoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Keratoacanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.2KRT17, KRT10, KRT16
2PCNA-p21 complexGO:07055710.0PCNA, CDKN1A

Biological processes related to Keratoacanthoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:00629810.4MSH2, PCNA, MLH1
2intrinsic apoptotic signaling pathwayGO:09719310.4BAK1, CDKN1A, GZMB
3organ regenerationGO:03110010.4BAK1, MKI67, CDKN1A
4response to UV-BGO:01022410.4IVL, MSH2
5negative regulation of gene expressionGO:01062910.3CDKN1A, BAK1, NME1
6collagen catabolic processGO:03057410.3MMP13, MMP10, MMP19
7isotype switchingGO:04519010.3MSH2, MLH1
8epidermis developmentGO:00854410.2CRABP2, KRT17, KRT16
9extracellular matrix disassemblyGO:02261710.1MMP13, MMP10, MMP19
10somatic hypermutation of immunoglobulin genesGO:01644610.0MSH2, MLH1

Molecular functions related to Keratoacanthoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1guanine/thymine mispair bindingGO:03213710.5MLH1, MSH2
2dinucleotide insertion or deletion bindingGO:03213910.4PCNA, MSH2
3MutLalpha complex bindingGO:03240510.4PCNA, MSH2
4retinoid bindingGO:00550110.3CRABP2, CRABP1
5single-stranded DNA bindingGO:00369710.2MSH2, MLH1, NME1
6metalloendopeptidase activityGO:00422210.2MMP13, MMP10, MMP19
7retinal bindingGO:01691810.1CRABP2, CRABP1
8retinol bindingGO:0198419.9CRABP2, CRABP1

Products for genes affiliated with Keratoacanthoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Keratoacanthoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet