MCID: KRT005
MIFTS: 39

Keratoacanthoma malady

Categories: Genetic diseases, Cancer diseases, Eye diseases, Skin diseases, Rare diseases

Aliases & Classifications for Keratoacanthoma

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Aliases & Descriptions for Keratoacanthoma:

Name: Keratoacanthoma 10 47 12 36 65

Classifications:



External Ids:

Disease Ontology10 DOID:3149
MeSH36 D007636
NCIt42 C3146
UMLS65 C0022572

Summaries for Keratoacanthoma

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Wikipedia:68 Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) skin tumour that is... more...

MalaCards based summary: Keratoacanthoma is related to muir-torre syndrome and contact dermatitis. An important gene associated with Keratoacanthoma is KRT10 (Keratin 10), and among its related pathways are Platinum Pathway, Pharmacokinetics/Pharmacodynamics and Colorectal Cancer Metastasis. Affiliated tissues include skin, breast and thyroid.

Related Diseases for Keratoacanthoma

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Diseases in the Keratoacanthoma family:

Familial Keratoacanthoma

Diseases related to Keratoacanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 472)
idRelated DiseaseScoreTop Affiliating Genes
1muir-torre syndrome32.1MLH1, MSH2
2contact dermatitis29.9FLG, KRT16
3generalized eruptive keratoacanthoma12.4
4familial keratoacanthoma12.4
5vulvar keratoacanthoma-like carcinoma12.3
6multiple self-healing squamous epithelioma, susceptiblity to11.7
7lymphatic system disease10.5MKI67, TP53
8vulvar clear cell hidradenocarcinoma10.4KRT10, TP53
9kidney leiomyosarcoma10.4MKI67, TP53
10splenogonadal fusion limb defects micrognatia10.4MKI67, TP53
11benign mesenchymoma10.4KRT10, TP53
12vulval paget's disease10.4MKI67, TP53
13vulva verrucous carcinoma10.4KRT10, TP53
14soft tissue sarcoma childhood10.4MKI67, TP53
15immune system cancer10.4MKI67, TP53
16osteoblastoma10.4MKI67, TP53
17vulvar granular cell tumor10.4GZMB, TP53
18small intestine leiomyosarcoma10.4MKI67, TP53
19autosomal dominant complex spastic paraplegia type 9a10.4MKI67, TP53
20small intestine cancer10.4GZMB, KRT10
21progressive muscular atrophy10.4MKI67, TP53
22sclerosteosis 110.4KRT10, KRT16
23fallopian tube transitional cell carcinoma10.4MKI67, TP53
24endotheliitis10.3
25prostatitis10.3
26congenital structural myopathy10.3MLH1, TP53
27periodic limb movement disorder10.3GZMB, KRT10, TP53
28mucocele of salivary gland10.3GZMB, MKI67, TP53
29hidradenitis10.3DSG2, KRT10
30capillary lymphangioma10.3DSG2, KRT10
31histoplasmosis10.3FLG, TP53
32endometrial disease10.3DSG1, MKI67
33pemphigus vulgaris10.3DSG1, DSG2
34lymphoma10.2
35epilepsy benign neonatal dominant form10.2FLG, KRT10
36vulvar sarcoma10.2KRT10, TP53
37venous hemangioma10.2FLG, KRT10
38skin pilomatrix carcinoma10.2FLG, KRT10
39braddock syndrome10.2DSG1, FLG
40hepatitis10.2
41peri-anal fistula10.2DSG1, DSG2
42biliary tract neoplasm10.2MLH1, TP53
43clove syndrome, somatic10.2KRT10, RBP1, TP53
44colorectal adenomatous polyposis, autosomal recessive, with pilomatricomas10.2FLG, KRT10
45ichthyosis-hypotrichosis-sclerosing cholangitis syndrome10.2DSG1, DSG2
46breast cancer10.2
47cerebritis10.2
48thyroiditis10.2
49ulnar neuropathy10.2MLH1, TP53
50myeloid leukemia10.2KRT10, KRT16, MKI67

Graphical network of the top 20 diseases related to Keratoacanthoma:



Diseases related to keratoacanthoma

Symptoms for Keratoacanthoma

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Drugs & Therapeutics for Keratoacanthoma

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Drugs for Keratoacanthoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DabrafenibapprovedPhase 27044462760, 44516822
Synonyms:
BRAF inhibitor GSK2118436
Dabrafenib
Dabrafenib Mesylate
 
GSK2118436
GSK2118436a
Tafinlar
dabrafenib
2
TrametinibapprovedPhase 2111871700-17-311707110
Synonyms:
GSK 1120212
GSK1120212
JTP 74057
JTP-74057
 
MEK Inhibitor GSK1120212
Mekinist
Trametinib Dimethyl Sulfoxide
Trametinibum
trametinib
3Protein Kinase InhibitorsPhase 23162
4
Sorafenibapproved, investigational671284461-73-0216239, 406563
Synonyms:
284461-73-0
4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide
4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide
4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate
4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide
4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE
AB1004622
AC-1674
AC1L50CF
BAX
BAY 43-9006
BAY 43-9006 (free base)
BAY 43-9006 tosylate salt
BAY 439006
BAY 54-9085 (tosylate salt)
BAY-43-0006
BAY-43-9006
BAY-54-9085
BAY43-9006
BRD-K23984367-001-01-8
Bio-0100
CHEBI:47228
CHEBI:50924
CHEMBL1336
CID216239
 
D08524
DB00398
DB07438
EN002709
I06-0856
K00597a
Kinome_766
LS-186067
LS-187021
LS-187788
MolPort-003-850-270
N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea
N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea
NCGC00167488-01
NSC-724772
NSC747971
Nexavar
STK627350
Sorafenib
Sorafenib (INN)
Sorafenib Tosylate
Sorafenib [INN]
Sorafenib tosylate
Sorafenibum
UNII-9ZOQ3TZI87
ZINC01493878
nchembio.117-comp17
sorafenib
sorafenibum

Interventional clinical trials:

idNameStatusNCT IDPhase
1Phase II Biomarker Study Comparing the Combination of BRAF Inhibitor Dabrafenib With MEK Inhibitor Trametinib Versus the Combination After Monotherapy With Dabrafenib or TrametinibRecruitingNCT02314143Phase 2
2A Pilot Study of Trientine With Vemurafenib for the Treatment BRAF Mutated Metastatic MelanomaWithdrawnNCT02068079Phase 1
3Prospective, Non-interventional, Post-authorization Safety Study That Includes All Patients Diagnosed as Unresectable Differentiated Thyroid Carcinoma and Treated With SorafenibRecruitingNCT02185560

Search NIH Clinical Center for Keratoacanthoma


Cochrane evidence based reviews: keratoacanthoma

Genetic Tests for Keratoacanthoma

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Anatomical Context for Keratoacanthoma

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MalaCards organs/tissues related to Keratoacanthoma:

33
Skin, Breast, Thyroid, Brain, Lung, Monocytes, T cells

Animal Models for Keratoacanthoma or affiliated genes

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Publications for Keratoacanthoma

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Articles related to Keratoacanthoma:

(show top 50)    (show all 577)
idTitleAuthorsYear
1
Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy. (26429917)
2015
2
Outpatient oral treatment for acute promyelocytic leukemia. (25714181)
2015
3
A case report of feline pituitary carcinoma with hypercortisolism. (24025433)
2014
4
Structure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist. (24502450)
2014
5
Pelvic inflammatory disease. (23704128)
2013
6
Neuroimaging, Behavioral, and Psychological Sequelae of Repetitive Combined Blast/Impact Mild Traumatic Brain Injury in Iraq and Afghanistan War Veterans. (24102309)
2013
7
Common variation contributes to the genetic architecture of social communication traits. (24047820)
2013
8
Phase 2 study of preoperative image-guided intensity-modulated radiation therapy to reduce wound and combined modality morbidities in lower extremity soft tissue sarcoma. (23423841)
2013
9
Osteoblast CFTR inactivation reduces differentiation and osteoprotegerin expression in a mouse model of cystic fibrosis-related bone disease. (24236172)
2013
10
A variant in IRF3 impacts on the clinical outcome of AML patients submitted to Allo-SCT. (23542224)
2013
11
Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1I+-MUC1 pathway. (23879962)
2013
12
Diagnostic difficulties in Krabbe disease: a report of two cases and review of literature. (23319190)
2012
13
Deregulation of the hypoxia inducible factor-1I+ pathway in monocytes from sporadic amyotrophic lateral sclerosis patients. (20977930)
2011
14
Human cognitive flexibility depends on dopamine D2 receptor signaling. (21611724)
2011
15
Abnormal expression of P2X family receptors in Chinese pediatric acute leukemias. (19919827)
2010
16
Imatinib mesylate (STI571)-induced cell edge translocation of kinase-active and kinase-defective Abelson kinase: requirements of myristoylation and src homology 3 domain. (18835981)
2009
17
JNK-dependent NFATc1 pathway positively regulates IL-13 gene expression induced by (-)-epigallocatechin-3-gallate in human basophilic KU812 cells. (19607912)
2009
18
Socio-environmental factors and ascariasis infection among school-aged children in Ilobu, Osun State, Nigeria. (19185897)
2009
19
Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing. (19218431)
2009
20
Sca-1 expression is required for efficient remodeling of the extracellular matrix during skeletal muscle regeneration. (19059231)
2009
21
The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma. (17195076)
2007
22
Acute myocardial infarction due to spontaneous coronary artery dissection treated with primary coronary angioplasty: a case report. (17700409)
2007
23
Differences in the incidence of flares or new onset of inflammatory bowel diseases in patients with ankylosing spondylitis exposed to therapy with anti-tumor necrosis factor alpha agents. (17471540)
2007
24
Outcome after kidney transplantation in children with thrombotic risk factors. (17032424)
2006
25
Meningeal hemangiopericytoma manifesting as massive intracranial hemorrhage--two case reports. (16498220)
2006
26
The Kell protein of the common K2 phenotype is a catalytically active metalloprotease, whereas the rare Kell K1 antigen is inactive. Identification of novel substrates for the Kell protein. (15769748)
2005
27
Brain natriuretic peptide: microalbuminuria for cardiac disease and diabetes? (15624097)
2005
28
Pharmacological basis of different targets for the treatment of atherosclerosis. (16364193)
2005
29
Specific pro-apoptotic fibronectin fragments modulate proteinase expression in periodontal ligament cells. (15152815)
2004
30
Metalloproteinase-2 expression correlates with aggressiveness of cutaneous squamous cell carcinomas. (14990972)
2004
31
Efficacy of insecticide mixtures against larvae of Culex quinquefasciatus (Say) (Diptera: Culicidae) resistant to pyrethroids and carbamates. (15119600)
2004
32
Increased expression of P21((WAF1/CIP1)) CDKI gene in chronic allograft nephropathy correlating with the number of acute rejection episodes. (12644083)
2003
33
TRPV3 is a calcium-permeable temperature-sensitive cation channel. (12077604)
2002
34
Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line. (12403071)
2002
35
Activation of leukocytes during the uteroplacental passage in preeclampsia. (11799095)
2002
36
Polymorphism and distribution of HLA-DR2 alleles in Mexican populations. (11250046)
2001
37
E-cadherin expression associated with differentiation and prognosis in patients with non-small cell lung cancer. (11269479)
2001
38
Regulation of the tyrosine hydroxylase and dopamine beta-hydroxylase genes by the transcription factor AP-2. (11146001)
2001
39
Molecular cloning and characterization of a mouse homolog of bacterial ClpX, a novel mammalian class II member of the Hsp100/Clp chaperone family. (10347188)
1999
40
Increased activity of citrate synthase in human skeletal muscle after a single bout of prolonged exercise. (9401597)
1997
41
Structural organization of the gene encoding the neuroendocrine chaperone 7B2. (8617287)
1996
42
Copper and gas-phase cigarette smoke inhibit plasma lecithin:cholesterol acyltransferase activity by different mechanisms. (7751820)
1995
43
Micronutrients in gastrointestinal cancer. (8260373)
1993
44
Acute beta-interferon or thymopentin administration increases plasma growth hormone and cortisol levels in children. (1414149)
1992
45
Fatal acute babesiosis in a juvenile wild dog (Lycaon pictus). (1569540)
1992
46
Dopamine beta-hydroxylase activity in cerebrospinal fluid of idiopathic torsion dystonia. (2215959)
1990
47
Coronary artery ectasia--a variant of occlusive coronary arteriosclerosis. (646906)
1978
48
Experimental hemarthrosis: the removal of chromium-51- and iron-59-labeled erythrocytes injected into the knee joint of rabbit and man. (14438187)
1960
49
Aspiration pneumonitis. (13452072)
1957
50

Variations for Keratoacanthoma

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Expression for genes affiliated with Keratoacanthoma

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Search GEO for disease gene expression data for Keratoacanthoma.

Pathways for genes affiliated with Keratoacanthoma

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GO Terms for genes affiliated with Keratoacanthoma

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Biological processes related to Keratoacanthoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1somatic recombination of immunoglobulin genes involved in immune responseGO:000220410.3MLH1, MSH2
2somatic recombination of immunoglobulin gene segmentsGO:001644710.3MLH1, MSH2
3double-strand break repairGO:000630210.0MSH2, TP53
4intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:00427719.8MSH2, TP53
5response to progesteroneGO:00325709.4DSG1, DSG2
6establishment of skin barrierGO:00614369.4FLG, KRT16
7cellular response to DNA damage stimulusGO:00069749.0MLH1, MSH2, TP53

Molecular functions related to Keratoacanthoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1double-stranded DNA bindingGO:00036909.8MSH2, TP53

Sources for Keratoacanthoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet