MCID: KRT005
MIFTS: 46

Keratoacanthoma malady

Categories: Genetic diseases, Cancer diseases, Eye diseases, Skin diseases, Rare diseases

Aliases & Classifications for Keratoacanthoma

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Aliases & Descriptions for Keratoacanthoma:

Name: Keratoacanthoma 11 50 39 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:3149
MeSH39 D007636
NCIt45 C3146

Summaries for Keratoacanthoma

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Wikipedia:71 Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) skin tumour that is... more...

MalaCards based summary: Keratoacanthoma is related to epidermolysis bullosa and generalized eruptive keratoacanthoma, and has symptoms including exanthema and pruritus. An important gene associated with Keratoacanthoma is MSH2 (MutS Homolog 2), and among its related pathways are Platinum Pathway, Pharmacokinetics/Pharmacodynamics and Transcriptional activation of cell cycle inhibitor p21. Affiliated tissues include skin, lung and colon, and related mouse phenotypes are digestive/alimentary and integument.

Related Diseases for Keratoacanthoma

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Diseases in the Keratoacanthoma family:

Familial Keratoacanthoma

Diseases related to Keratoacanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1epidermolysis bullosa28.8DSG1, FLG, KRT16
2generalized eruptive keratoacanthoma12.0
3familial keratoacanthoma12.0
4muir-torre syndrome11.8
5vulvar keratoacanthoma-like carcinoma11.8
6multiple self-healing squamous epithelioma, susceptiblity to11.4
7corneal intraepithelial dyskeratosis and ectodermal dysplasia10.8
8squamous cell carcinoma10.6
9wolffian adnexal neoplasm10.3MKI67, TP53
10spondylarthropathy10.3MKI67, TP53
11plasmodium ovale malaria10.2GZMB, MKI67, TP53
12ebola hemorrhagic fever10.2KRT10, KRT17
13breast epithelioid hemangioma10.2CDKN1A, TP53
14inverted follicular keratosis10.2CDKN1A, TP53
15anal margin basal cell carcinoma10.2KRT10, KRT17
16large intestine adenoma10.2MLH1, MSH2
17episodic angioedema with eosinophilia10.2FLG, KRT10
18mixed cell adenoma10.2KRT10, KRT17
19pneumonia caused by pseudomonas aeruginosa infection10.1DSG1, FLG
20oro-mandibular-limb hypogenesis syndrome10.1MKI67, TP53
21benign fibrous mesothelioma10.1MLH1, MSH2
22insulinoma10.1FLG, KRT10
23skin melanoma10.1MLH1, MSH2
24perineural angioma10.1CDKN1A, TP53
25acute mountain sickness10.1CDKN1A, MSH2, TP53
26orchitis10.1KRT10, KRT17, TP53
27scarlet fever10.1CDKN1A, MSH2, TP53
28toxic megacolon10.1CDKN1A, MSH2, TP53
29aorta atresia10.1MLH1, MSH2
30fibrolamellar carcinoma10.1MLH1, MSH2
31small intestine leiomyoma10.1FLG, KRT17, TP53
32prostate cancer, hereditary, x-linked 110.1CDKN1A, MSH2, TP53
33cervical verrucous carcinoma10.1CDKN1A, KRT10, TP53
34dysembryoplastic neuroepithelial tumor10.1CDKN1A, MSH2, TP53
35familial hypopituitarism10.1MLH1, MSH2, TP53
36prostatic adenoma10.1MKI67, MLH1, TP53
37ideomotor apraxia10.1MLH1, MSH2, TP53
38larynx liposarcoma10.1MLH1, MSH2, TP53
39congenital symblepharon10.1MLH1, MSH2, TP53
40asperger syndrome10.1MLH1, MSH2, TP53
41sclerosteosis 110.1KRT16, KRT17
42oral squamous cell carcinoma10.1MLH1, MSH2, TP53
43endometrial squamous cell carcinoma10.1MLH1, TP53
44rectum sarcoma10.1MLH1, MSH2, TP53
45trachea squamous cell carcinoma10.1MLH1, MSH2, TP53
46t-cell large granular lymphocyte leukemia10.0MLH1, MSH2, TP53
47intraocular retinoblastoma10.0FLG, KRT10, KRT17
48cauda equina neoplasm10.0KRT17, MLH1, MSH2
49chronic mountain sickness10.0KRT16, KRT17
50placenta praevia10.0CDKN1A, MKI67, TP53

Graphical network of the top 20 diseases related to Keratoacanthoma:



Diseases related to keratoacanthoma

Symptoms & Phenotypes for Keratoacanthoma

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UMLS symptoms related to Keratoacanthoma:


exanthema, pruritus

MGI Mouse Phenotypes related to Keratoacanthoma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.3CDKN1A, KRT16, KRT17, MLH1, MSH2, TP53
2MP:00107717.6CDKN1A, KRT16, KRT17, MLH1, MSH2, TP53

Drugs & Therapeutics for Keratoacanthoma

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Drugs for Keratoacanthoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DabrafenibapprovedPhase 28444462760, 44516822
Synonyms:
BRAF inhibitor GSK2118436
Dabrafenib
 
GSK2118436
GSK2118436a
Tafinlar
dabrafenib
2
TrametinibapprovedPhase 2131871700-17-311707110
Synonyms:
GSK 1120212
GSK1120212
JTP 74057
JTP-74057
 
MEK Inhibitor GSK1120212
Mekinist
Trametinib Dimethyl Sulfoxide
Trametinibum
trametinib
3
nivolumabapprovedPhase 2424946414-94-4
Synonyms:
BMS-936558
 
MDX-1106
ONO-4538
nivolumab
4Protein Kinase InhibitorsPhase 23689
5ImmunoglobulinsPhase 26394
6Antibodies, MonoclonalPhase 24039
7AntibodiesPhase 26394
8
Sorafenibapproved, investigational700284461-73-0216239, 406563
Synonyms:
284461-73-0
4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide
4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide
4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate
4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide
4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE
AB1004622
AC-1674
AC1L50CF
BAX
BAY 43-9006
BAY 43-9006 (free base)
BAY 43-9006 tosylate salt
BAY 439006
BAY 54-9085 (tosylate salt)
BAY-43-0006
BAY-43-9006
BAY-54-9085
BAY43-9006
BRD-K23984367-001-01-8
Bio-0100
CHEBI:47228
CHEBI:50924
CHEMBL1336
CID216239
 
D08524
DB00398
DB07438
EN002709
I06-0856
K00597a
Kinome_766
LS-186067
LS-187021
LS-187788
MolPort-003-850-270
N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea
N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea
NCGC00167488-01
NSC-724772
NSC747971
Nexavar
STK627350
Sorafenib
Sorafenib (INN)
Sorafenib [INN]
Sorafenib tosylate
Sorafenibum
UNII-9ZOQ3TZI87
ZINC01493878
nchembio.117-comp17
sorafenib
sorafenibum
9
Niacinapproved, investigational, nutraceutical92359-67-6938
Synonyms:
3-Carboxylpyridine
3-Carboxypyridine
3-Pyridinecarboxylate
3-Pyridinecarboxylic acid
3-Pyridylcarboxylate
3-Pyridylcarboxylic acid
3-carboxypyridine
Acide Nicotinique
Acido nicotinico
Acidum Nicotinicum
Akotin
Anti-pellagra vitamin
Apelagrin
Daskil
Efacin
Enduracin
Linic
M-Pyridinecarboxylic Acid
Niac
Niacin
Niacine
Niacor
Nicacid
Nicamin
Nicangin
 
Nico-Span
Nicobid
Nicocap
Nicodelmine
Nicolar
Niconacid
Nicosan 3
Nicotinate
Nicotinic Acid
Nicotinic acid
Nicotinipca
Nicyl
Nikotinsaeure
Nyclin
P.P. factor
PP Factor
Pellagra preventive factor
Pellagrin
Pelonin
Pyridine-beta-carboxylic acid
Slo-niacin
Vitamin B3
Wampocap
beta-Pyridinecarboxylic acid
pyridine-╬▓-carboxylic acid
╬▓-pyridinecarboxylic acid
10
Nicotinamideapproved, Nutraceutical91998-92-0936
Synonyms:
.beta.-Pyridinecarboxamide
11032-50-1
123574-63-0
1yc5
3 Pyridinecarboxamide
3-Carbamoylpyridine
3-Pyridinecarboxamide
3-Pyridinecarboxylic acid amide
37321-14-5
47865U_SUPELCO
55600-01-6
63748-44-7
72340_FLUKA
72340_SIGMA
72347_FLUKA
78731-47-2
98-92-0
A186B02E-6C70-4E54-9739-79398D439AAA
AC-907/25014114
AC1L1ACZ
AC1Q4ZFV
AI3-02906
Acid amide
Amid kyseliny nikotinove
Amid kyseliny nikotinove [Czech]
Amide PP
Aminicotin
Amixicotyn
Amnicotin
Astra Brand of Niacinamide
Austrovit PP
B 3, Vitamin
B3, Vitamin
BB_NC-2290
Benicot
C00153
C6H6N2O
CCRIS 1901
CHEBI:17154
CHEMBL1140
CID936
CPD000058212
D00036
D009536
DB02701
DEA No. 1405
Delonin Amide
Delonin amide
Dipegyl
Dipigyl
EINECS 202-713-4
EINECS 234-265-0
Endobion
Enduramide
Factor pp
HMS2052M21
HMS2090B05
HMS2093H03
HSDB 1237
Hansamid
I02-1741
I02-2250
InChI=1/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9
Inovitan PP
Jenapharm Brand of Niacinamide
Jenapharm, Nicotinsaureamid
LS-2051
MLS000069714
Mediatric
Merck Brand of Niacinamide
MolMap_000061
MolPort-001-783-876
N0078
N0636_SIGMA
N2142_SIGMA
N3376_SIGMA
N5535_SIAL
NAM
NCGC00093354-03
NCGC00093354-04
NSC 13128
NSC13128
NSC27452
Nandervit-N
Niacevit
Niacinamide
Niacinamide (USP)
Niacinamide Astra Brand
Niacinamide Jenapharm Brand
Niacinamide Merck Brand
 
Niacinamide Pharmagenix Brand
Niacinamide [USAN]
Niacinamide, Nicotinic acid amide, Nicotinamide
Niacotinamide
Niamide
Niavit PP
Nicamide
Nicamina
Nicamindon
Nicasir
Nicobion
Nicofort
Nicogen
Nicomidol
Nicosan 2
Nicosylamide
Nicota
Nicotamide
Nicotilamide
Nicotililamido
Nicotinamid
Nicotinamida
Nicotinamida [INN-Spanish]
Nicotinamide
Nicotinamide (JP15/INN)
Nicotinamide (Niacinamide)
Nicotinamide, niacin, vitamin B3
Nicotinamide-carbonyl-14C
Nicotinamidum
Nicotinamidum [INN-Latin]
Nicotine acid amide
Nicotine amide
Nicotinic acid amide
Nicotinic amide
Nicotinsaeureamid
Nicotinsaureamid
Nicotinsaureamid Jenapharm
Nicotinsaureamid [German]
Nicotol
Nicotylamide
Nicotylamidum
Nicovel
Nicovit
Nicovitina
Nicovitol
Nicozymin
Nictoamide
Nikasan
Nikazan
Niko-tamin
Nikotinamid
Nikotinsaeureamid
Nikotinsaeureamid [German]
Niocinamide
Niozymin
PP-Faktor
Papulex
Pelmin
Pelmine
Pelonin amide
Pharmagenix Brand of Niacinamide
Propamine A
Pyridine-3-carboxylic acid amide
S1899_Selleck
SAM001246860
SGCUT00176
SMR000058212
Savacotyl
UNII-25X51I8RD4
Vi-Nicotyl
Vi-noctyl
Vitamin B
Vitamin B (VAN)
Vitamin B 3
Vitamin B3 amide
Vitamin H1
Vitamin PP
WLN: T6NJ CVZ
Witamina PP
ZINC00005878
b-Pyridinecarboxamide
beta-Pyridinecarboxamide
bmse000281
m-(Aminocarbonyl)pyridine
nchembio.154-comp4
nchembio.73-comp6
niacin - Vitamin B3
niacinamide
nicotinamide
pyridine-3-carboxamide
to_000073
vitamin PP
11
Folic Acidapproved, nutraceutical, vet_approved439259-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
12Trace Elements6001
13Vitamin B Complex4337
14Vitamins5282
15Micronutrients6001
16Nicotinic Acids923
17FolateNutraceutical4392
18Vitamin B3Nutraceutical923
19Vitamin B9Nutraceutical4392

Interventional clinical trials:

idNameStatusNCT IDPhase
1Phase II Biomarker Study Comparing the Combination of BRAF Inhibitor Dabrafenib With MEK Inhibitor Trametinib Versus the Combination After Monotherapy With Dabrafenib or TrametinibRecruitingNCT02314143Phase 2
2Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin CancersNot yet recruitingNCT02978625Phase 2
3A Pilot Study of Trientine With Vemurafenib for the Treatment BRAF Mutated Metastatic MelanomaWithdrawnNCT02068079Phase 1
4Prospective, Non-interventional, Post-authorization Safety Study That Includes All Patients Diagnosed as Unresectable Differentiated Thyroid Carcinoma and Treated With SorafenibRecruitingNCT02185560
5Tolerance of Targeted Therapy Used in Metastatic Melanoma in Patients Aged Over 65 and 75-year-oldRecruitingNCT03155217

Search NIH Clinical Center for Keratoacanthoma


Cochrane evidence based reviews: keratoacanthoma

Genetic Tests for Keratoacanthoma

About this section

Anatomical Context for Keratoacanthoma

About this section

MalaCards organs/tissues related to Keratoacanthoma:

36
Skin, Lung, Colon, Bone, Cervix, Myeloid, Tongue

Publications for Keratoacanthoma

About this section

Articles related to Keratoacanthoma:

(show top 50)    (show all 609)
idTitleAuthorsYear
1
Reduced expression of the ATP2A2 gene in vemurafenib-induced keratoacanthoma-like papules in a melanoma patient. (27805257)
2017
2
Keratoacanthoma-like dermatofibroma: A dermoscopic challenge. (28087033)
2017
3
Keratoacanthoma-Like Growths of Incontinentia Pigmenti Successfully Treated with Intralesional Methotrexate. (28414858)
2017
4
Nevoid Eruptive Keratoacanthoma" - Yet Another Atypical Manifestation of Generalized Keratoacanthoma. (26955113)
2016
5
The distinction of keratoacanthoma from various types of squamous cell carcinoma with crateriform architecture. (27670127)
2016
6
Systemic methotrexate for prurigo nodularis and keratoacanthomas in actinically damaged skin. (27486591)
2016
7
Keratoacanthoma of the conjunctiva in a young patient. (27463634)
2016
8
Unusual Ultrasound Appearance of Subungual Keratoacanthoma With Clinical and Histological Correlation. (26833061)
2016
9
Distal Digital Keratoacanthoma in Patients With Incontinentia Pigmenti. (26614487)
2016
10
Giant keratoacanthoma of the lower lip: case report and review of the published literature. (26742162)
2016
11
Keratoacanthoma formation after skin grafting: A brief report and pathophysiological hypothesis. (27273800)
2016
12
Keratoacanthoma Arising Over Margin of Porokeratosis of Mibelli: A New Association? (26955114)
2016
13
Acute development of keratoacanthoma at a full-thickness skin graft donor site shortly after surgery. (27027399)
2016
14
Aberrant DNA Methylation in Keratoacanthoma. (27788211)
2016
15
Subungual Keratoacanthoma in a Patient With Yellow Nail Syndrome. (27158885)
2016
16
Human polyomavirus DNA detection in keratoacanthoma and Spitz naevus: no evidence for a causal role. (27993945)
2016
17
Keratoacanthoma (KA): An update and review. (26853179)
2016
18
Insulin-like growth factor 2 mRNA-binding protein-3 as a marker for distinguishing between cutaneous squamous cell carcinoma and keratoacanthoma. (26782292)
2016
19
Keratoacanthoma-appearing melanoma metastases in a patient receiving pembrolizumab therapy. (27408934)
2016
20
Clues in DeRmoscopy: Dermoscopy of keratoacanthoma. (27528474)
2016
21
Subungual keratoacanthoma in a pianist. (27348330)
2016
22
Clinicopathological study of crateriform verruca: Crateriform epithelial lesions histopathologically distinct from keratoacanthoma. (26970425)
2016
23
Keratoacanthoma Shares Driver Mutations with Cutaneous Squamous Cell Carcinoma. (27283355)
2016
24
Cutaneous Epithelial Lesions Induced by N-Methyl-N-nitrosourea in Male Sprague-Dawley Rats: A Possible Animal Model for Human Keratoacanthoma. (26722034)
2016
25
Histopathological diagnosis of epithelial crateriform tumors: Keratoacanthoma and other epithelial crateriform tumors. (27076258)
2016
26
Sonographic features of keratoacanthoma. May ultrasound be a useful tool to differentiate it from squamous cell carcinoma? (26681149)
2016
27
Keratoacanthoma centrifugum marginatum: A diagnostic and therapeutic challenge. (27274538)
2016
28
Crater/ulcerated form of infundibular squamous cell carcinoma: A possible distinct entity as a malignant (or high-grade) counterpart to keratoacanthoma. (25854192)
2015
29
Squamous Cell Carcinoma Arising From Keratoacanthoma: An Evaluation by RT-PCR. (26067455)
2015
30
Prevalence of human papillomavirus infection and RAS mutation in sporadic keratoacanthoma. (26016383)
2015
31
Verrucous seborrheic keratosis with keratoacanthoma-like features, a pitfall in differential diagnosis. (26882384)
2015
32
Differentiating Early Stage Cystic Keratoacanthoma, Nodular Basal Cell Carcinoma, and Excoriated Acne Vulgaris by Clinical Exam, Dermoscopy, and Optical Coherence Tomography: A Report of 3 Cases. (26060518)
2015
33
Keratoacanthoma and squamous cell carcinoma are distinct from a molecular perspective. (25676557)
2015
34
A case of keratoacanthoma associated with Basal cell carcinoma. (25834377)
2015
35
Management of keratoacanthoma in patients with xeroderma pigmentosum: a challenge for clinicians. (26388200)
2015
36
Acitretin induces remission in generalized eruptive keratoacanthoma of Grzybowski. (25615899)
2015
37
Keratoacanthoma of Upper Lip: Review and Report of Case Managed Surgically. (26557626)
2015
38
Subungual Keratoacanthoma. (26677286)
2015
39
Eruptive squamous cell carcinomas with keratoacanthoma-like features in a patient treated with ruxolitinib. (25997466)
2015
40
Canine nail bed keratoacanthoma diagnosed by immunohistochemical analysis. (26538676)
2015
41
Case of generalized eruptive keratoacanthoma with probable SjAPgren's syndrome. (26119532)
2015
42
CD1A-positive cells and HSP60 (HSPD1) levels in keratoacanthoma and squamous cell carcinoma. (26442925)
2015
43
Eruptive Syringocystadenoma Papilliferum, Keratoacanthoma, and Verruca Vulgaris in a Keratinocytic Epidermal Nevus on the Leg. (26790513)
2015
44
Generalized eruptive keratoacanthoma of Grzybowski. (26137745)
2015
45
Keratoacanthoma: A distinct entity? (26476131)
2015
46
Multiple giant angiokeratoma of Fordyce on the shaft of the penis masquerading as keratoacanthoma. (26312700)
2015
47
Unique subungueal keratoacanthoma revealing incontinentia pigmenti. (26387562)
2015
48
Don't miss the base - keratoacanthoma-type squamous cell carcinoma with perineural invasion during BRAF inhibitor therapy for melanoma. (26612802)
2015
49
Expression of Cyclooxygenase-2 in Squamous Cell Carcinoma and Keratoacanthoma and its Clinical Significance. (25575894)
2015
50
Keratoacanthoma of the Lip: Activation of the mTOR Pathway, Tumor Suppressor Proteins, and Tumor Senescence. (26402814)
2015

Variations for Keratoacanthoma

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Expression for genes affiliated with Keratoacanthoma

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Search GEO for disease gene expression data for Keratoacanthoma.

Pathways for genes affiliated with Keratoacanthoma

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Pathways related to Keratoacanthoma according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
19.6MLH1, MSH2
2
Show member pathways
9.6CDKN1A, TP53
3
Show member pathways
9.6CDKN1A, TP53
49.6CDKN1A, TP53
59.6CDKN1A, TP53
69.3CDKN1A, MSH2, TP53
79.3CDKN1A, KRT17, TP53
89.3CDKN1A, GZMB, TP53
9
Show member pathways
9.2MLH1, MSH2, TP53
109.1CDKN1A, RBP1, TP53
118.7CDKN1A, MLH1, MSH2, TP53
12
Show member pathways
8.7CDKN1A, MLH1, MSH2, TP53
138.7CDKN1A, MLH1, MSH2, TP53
148.7CDKN1A, MLH1, MSH2, TP53
15
Show member pathways
8.7CDKN1A, MLH1, MSH2, TP53
168.7CDKN1A, MLH1, MSH2, TP53
178.3CDKN1A, MKI67, MLH1, MSH2, TP53
18
Show member pathways
8.1DSG1, FLG, KRT10, KRT16, KRT17

GO Terms for genes affiliated with Keratoacanthoma

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Cellular components related to Keratoacanthoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1condensed chromosomeGO:000079310.3MKI67, MLH1
2cornified envelopeGO:000153310.0DSG1, FLG, KRT10
3intermediate filamentGO:00058828.5FLG, KRT10, KRT16, KRT17
4cytosolGO:00058297.0CDKN1A, DSG1, FLG, GZMB, KRT10, KRT16

Biological processes related to Keratoacanthoma according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1determination of adult lifespanGO:000834010.5MSH2, TP53
2positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:190074010.3GZMB, TP53
3cellular response to gamma radiationGO:007148010.3CDKN1A, TP53
4cellular response to ionizing radiationGO:007147910.3CDKN1A, TP53
5DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.2CDKN1A, TP53
6intrinsic apoptotic signaling pathwayGO:009719310.2CDKN1A, TP53
7isotype switchingGO:004519010.2MLH1, MSH2
8positive regulation of isotype switching to IgA isotypesGO:004829810.1MLH1, MSH2
9positive regulation of isotype switching to IgG isotypesGO:004830410.1MLH1, MSH2
10positive regulation of reactive oxygen species metabolic processGO:200037910.1CDKN1A, TP53
11meiotic nuclear divisionGO:000712610.1MKI67, MLH1
12replicative senescenceGO:009039910.0CDKN1A, TP53
13cell cycle arrestGO:000705010.0CDKN1A, MSH2, TP53
14skin epidermis developmentGO:009877310.0FLG, KRT10
15signal transduction by p53 class mediatorGO:007233110.0CDKN1A, TP53
16intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:004277110.0CDKN1A, MSH2, TP53
17establishment of skin barrierGO:00614369.8FLG, KRT16
18somatic hypermutation of immunoglobulin genesGO:00164469.7MLH1, MSH2
19response to X-rayGO:00101659.7CDKN1A, MSH2, TP53
20somatic recombination of immunoglobulin genes involved in immune responseGO:00022049.6MLH1, MSH2
21somatic recombination of immunoglobulin gene segmentsGO:00164479.5MLH1, MSH2
22keratinocyte differentiationGO:00302169.4FLG, KRT10, KRT16
23cellular response to DNA damage stimulusGO:00069749.4CDKN1A, MLH1, MSH2, TP53
24keratinizationGO:00314249.3DSG1, KRT10, KRT16, KRT17
25cornificationGO:00702688.8DSG1, FLG, KRT10, KRT16, KRT17

Molecular functions related to Keratoacanthoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1guanine/thymine mispair bindingGO:003213710.0MLH1, MSH2
2mismatched DNA bindingGO:00309839.9MLH1, MSH2
3structural constituent of epidermisGO:00302809.7FLG, KRT10

Sources for Keratoacanthoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet