MCID: KRT005
MIFTS: 46

Keratoacanthoma malady

Categories: Cancer diseases, Eye diseases, Skin diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Keratoacanthoma

Aliases & Descriptions for Keratoacanthoma:

Name: Keratoacanthoma 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3149
MeSH 42 D007636
NCIt 47 C3146
UMLS 69 C0022572

Summaries for Keratoacanthoma

MalaCards based summary : Keratoacanthoma is related to epidermolysis bullosa and generalized eruptive keratoacanthoma, and has symptoms including exanthema and pruritus. An important gene associated with Keratoacanthoma is MSH2 (MutS Homolog 2), and among its related pathways/superpathways are Pathways in cancer and Endometrial cancer. The drugs Dabrafenib and Trametinib have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and bone, and related phenotypes are digestive/alimentary and integument

Wikipedia : 71 Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) skin tumour that is... more...

Related Diseases for Keratoacanthoma

Diseases in the Keratoacanthoma family:

Familial Keratoacanthoma

Diseases related to Keratoacanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
id Related Disease Score Top Affiliating Genes
1 epidermolysis bullosa 28.8 DSG1 FLG KRT16
2 generalized eruptive keratoacanthoma 12.0
3 familial keratoacanthoma 12.0
4 muir-torre syndrome 11.8
5 vulvar keratoacanthoma-like carcinoma 11.8
6 multiple self-healing squamous epithelioma, susceptiblity to 11.4
7 corneal intraepithelial dyskeratosis and ectodermal dysplasia 10.8
8 squamous cell carcinoma 10.6
9 wolffian adnexal neoplasm 10.3 MKI67 TP53
10 spondylarthropathy 10.3 MKI67 TP53
11 plasmodium ovale malaria 10.2 GZMB MKI67 TP53
12 ebola hemorrhagic fever 10.2 KRT10 KRT17
13 breast epithelioid hemangioma 10.2 CDKN1A TP53
14 inverted follicular keratosis 10.2 CDKN1A TP53
15 anal margin basal cell carcinoma 10.2 KRT10 KRT17
16 large intestine adenoma 10.2 MLH1 MSH2
17 episodic angioedema with eosinophilia 10.2 FLG KRT10
18 mixed cell adenoma 10.2 KRT10 KRT17
19 pneumonia caused by pseudomonas aeruginosa infection 10.1 DSG1 FLG
20 oro-mandibular-limb hypogenesis syndrome 10.1 MKI67 TP53
21 benign fibrous mesothelioma 10.1 MLH1 MSH2
22 insulinoma 10.1 FLG KRT10
23 skin melanoma 10.1 MLH1 MSH2
24 perineural angioma 10.1 CDKN1A TP53
25 acute mountain sickness 10.1 CDKN1A MSH2 TP53
26 orchitis 10.1 KRT10 KRT17 TP53
27 scarlet fever 10.1 CDKN1A MSH2 TP53
28 toxic megacolon 10.1 CDKN1A MSH2 TP53
29 aorta atresia 10.1 MLH1 MSH2
30 fibrolamellar carcinoma 10.1 MLH1 MSH2
31 small intestine leiomyoma 10.1 FLG KRT17 TP53
32 prostate cancer, hereditary, x-linked 1 10.1 CDKN1A MSH2 TP53
33 cervical verrucous carcinoma 10.1 CDKN1A KRT10 TP53
34 dysembryoplastic neuroepithelial tumor 10.1 CDKN1A MSH2 TP53
35 familial hypopituitarism 10.1 MLH1 MSH2 TP53
36 prostatic adenoma 10.1 MKI67 MLH1 TP53
37 ideomotor apraxia 10.1 MLH1 MSH2 TP53
38 larynx liposarcoma 10.1 MLH1 MSH2 TP53
39 congenital symblepharon 10.1 MLH1 MSH2 TP53
40 asperger syndrome 10.1 MLH1 MSH2 TP53
41 sclerosteosis 1 10.1 KRT16 KRT17
42 oral squamous cell carcinoma 10.1 MLH1 MSH2 TP53
43 endometrial squamous cell carcinoma 10.1 MLH1 TP53
44 rectum sarcoma 10.1 MLH1 MSH2 TP53
45 trachea squamous cell carcinoma 10.1 MLH1 MSH2 TP53
46 t-cell large granular lymphocyte leukemia 10.0 MLH1 MSH2 TP53
47 intraocular retinoblastoma 10.0 FLG KRT10 KRT17
48 cauda equina neoplasm 10.0 KRT17 MLH1 MSH2
49 chronic mountain sickness 10.0 KRT16 KRT17
50 placenta praevia 10.0 CDKN1A MKI67 TP53

Graphical network of the top 20 diseases related to Keratoacanthoma:



Diseases related to Keratoacanthoma

Symptoms & Phenotypes for Keratoacanthoma

UMLS symptoms related to Keratoacanthoma:


exanthema, pruritus

MGI Mouse Phenotypes related to Keratoacanthoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 CDKN1A KRT16 KRT17 MLH1 MSH2 TP53
2 integument MP:0010771 9.1 CDKN1A KRT16 KRT17 MLH1 MSH2 TP53

Drugs & Therapeutics for Keratoacanthoma

Drugs for Keratoacanthoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dabrafenib Approved Phase 2 44462760 44516822
2
Trametinib Approved Phase 2 871700-17-3 11707110
3
nivolumab Approved Phase 2 946414-94-4
4 Protein Kinase Inhibitors Phase 2
5 Antibodies Phase 2
6 Antibodies, Monoclonal Phase 2
7 Immunoglobulins Phase 2
8
Sorafenib Approved, Investigational 284461-73-0 216239 406563
9
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
10
Niacin Approved, Investigational, Nutraceutical 59-67-6 938
11
Nicotinamide Approved, Nutraceutical 98-92-0 936
12 Micronutrients
13 Nicotinic Acids
14 Trace Elements
15 Vitamin B Complex
16 Vitamins
17 Folate Nutraceutical
18 Vitamin B3 Nutraceutical
19 Vitamin B9 Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 Phase II Biomarker Study Comparing the Combination of BRAF Inhibitor Dabrafenib With MEK Inhibitor Trametinib Versus the Combination After Monotherapy With Dabrafenib or Trametinib Recruiting NCT02314143 Phase 2
2 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Not yet recruiting NCT02978625 Phase 2
3 A Pilot Study of Trientine With Vemurafenib for the Treatment BRAF Mutated Metastatic Melanoma Withdrawn NCT02068079 Phase 1
4 Prospective, Non-interventional, Post-authorization Safety Study That Includes All Patients Diagnosed as Unresectable Differentiated Thyroid Carcinoma and Treated With Sorafenib Recruiting NCT02185560
5 Tolerance of Targeted Therapy Used in Metastatic Melanoma in Patients Aged Over 65 and 75-year-old Recruiting NCT03155217

Search NIH Clinical Center for Keratoacanthoma

Cochrane evidence based reviews: keratoacanthoma

Genetic Tests for Keratoacanthoma

Anatomical Context for Keratoacanthoma

MalaCards organs/tissues related to Keratoacanthoma:

39
Skin, Lung, Bone, Colon, Myeloid, Tongue, Cervix

Publications for Keratoacanthoma

Articles related to Keratoacanthoma:

(show top 50) (show all 609)
id Title Authors Year
1
Reduced expression of the ATP2A2 gene in vemurafenib-induced keratoacanthoma-like papules in a melanoma patient. ( 27805257 )
2017
2
Keratoacanthoma-like dermatofibroma: A dermoscopic challenge. ( 28087033 )
2017
3
Keratoacanthoma-Like Growths of Incontinentia Pigmenti Successfully Treated with Intralesional Methotrexate. ( 28414858 )
2017
4
"Nevoid Eruptive Keratoacanthoma" - Yet Another Atypical Manifestation of Generalized Keratoacanthoma. ( 26955113 )
2016
5
The distinction of keratoacanthoma from various types of squamous cell carcinoma with crateriform architecture. ( 27670127 )
2016
6
Systemic methotrexate for prurigo nodularis and keratoacanthomas in actinically damaged skin. ( 27486591 )
2016
7
Keratoacanthoma of the conjunctiva in a young patient. ( 27463634 )
2016
8
Unusual Ultrasound Appearance of Subungual Keratoacanthoma With Clinical and Histological Correlation. ( 26833061 )
2016
9
Distal Digital Keratoacanthoma in Patients With Incontinentia Pigmenti. ( 26614487 )
2016
10
Giant keratoacanthoma of the lower lip: case report and review of the published literature. ( 26742162 )
2016
11
Keratoacanthoma formation after skin grafting: A brief report and pathophysiological hypothesis. ( 27273800 )
2016
12
Keratoacanthoma Arising Over Margin of Porokeratosis of Mibelli: A New Association? ( 26955114 )
2016
13
Acute development of keratoacanthoma at a full-thickness skin graft donor site shortly after surgery. ( 27027399 )
2016
14
Aberrant DNA Methylation in Keratoacanthoma. ( 27788211 )
2016
15
Subungual Keratoacanthoma in a Patient With Yellow Nail Syndrome. ( 27158885 )
2016
16
Human polyomavirus DNA detection in keratoacanthoma and Spitz naevus: no evidence for a causal role. ( 27993945 )
2016
17
Keratoacanthoma (KA): An update and review. ( 26853179 )
2016
18
Insulin-like growth factor 2 mRNA-binding protein-3 as a marker for distinguishing between cutaneous squamous cell carcinoma and keratoacanthoma. ( 26782292 )
2016
19
Keratoacanthoma-appearing melanoma metastases in a patient receiving pembrolizumab therapy. ( 27408934 )
2016
20
Clues in DeRmoscopy: Dermoscopy of keratoacanthoma. ( 27528474 )
2016
21
Subungual keratoacanthoma in a pianist. ( 27348330 )
2016
22
Clinicopathological study of crateriform verruca: Crateriform epithelial lesions histopathologically distinct from keratoacanthoma. ( 26970425 )
2016
23
Keratoacanthoma Shares Driver Mutations with Cutaneous Squamous Cell Carcinoma. ( 27283355 )
2016
24
Cutaneous Epithelial Lesions Induced by N-Methyl-N-nitrosourea in Male Sprague-Dawley Rats: A Possible Animal Model for Human Keratoacanthoma. ( 26722034 )
2016
25
Histopathological diagnosis of epithelial crateriform tumors: Keratoacanthoma and other epithelial crateriform tumors. ( 27076258 )
2016
26
Sonographic features of keratoacanthoma. May ultrasound be a useful tool to differentiate it from squamous cell carcinoma? ( 26681149 )
2016
27
Keratoacanthoma centrifugum marginatum: A diagnostic and therapeutic challenge. ( 27274538 )
2016
28
Crater/ulcerated form of infundibular squamous cell carcinoma: A possible distinct entity as a malignant (or high-grade) counterpart to keratoacanthoma. ( 25854192 )
2015
29
Squamous Cell Carcinoma Arising From Keratoacanthoma: An Evaluation by RT-PCR. ( 26067455 )
2015
30
Prevalence of human papillomavirus infection and RAS mutation in sporadic keratoacanthoma. ( 26016383 )
2015
31
Verrucous seborrheic keratosis with keratoacanthoma-like features, a pitfall in differential diagnosis. ( 26882384 )
2015
32
Differentiating Early Stage Cystic Keratoacanthoma, Nodular Basal Cell Carcinoma, and Excoriated Acne Vulgaris by Clinical Exam, Dermoscopy, and Optical Coherence Tomography: A Report of 3 Cases. ( 26060518 )
2015
33
Keratoacanthoma and squamous cell carcinoma are distinct from a molecular perspective. ( 25676557 )
2015
34
A case of keratoacanthoma associated with Basal cell carcinoma. ( 25834377 )
2015
35
Management of keratoacanthoma in patients with xeroderma pigmentosum: a challenge for clinicians. ( 26388200 )
2015
36
Acitretin induces remission in generalized eruptive keratoacanthoma of Grzybowski. ( 25615899 )
2015
37
Keratoacanthoma of Upper Lip: Review and Report of Case Managed Surgically. ( 26557626 )
2015
38
Subungual Keratoacanthoma. ( 26677286 )
2015
39
Eruptive squamous cell carcinomas with keratoacanthoma-like features in a patient treated with ruxolitinib. ( 25997466 )
2015
40
Canine nail bed keratoacanthoma diagnosed by immunohistochemical analysis. ( 26538676 )
2015
41
Case of generalized eruptive keratoacanthoma with probable SjAPgren's syndrome. ( 26119532 )
2015
42
CD1A-positive cells and HSP60 (HSPD1) levels in keratoacanthoma and squamous cell carcinoma. ( 26442925 )
2015
43
Eruptive Syringocystadenoma Papilliferum, Keratoacanthoma, and Verruca Vulgaris in a Keratinocytic Epidermal Nevus on the Leg. ( 26790513 )
2015
44
Generalized eruptive keratoacanthoma of Grzybowski. ( 26137745 )
2015
45
Keratoacanthoma: A distinct entity? ( 26476131 )
2015
46
Multiple giant angiokeratoma of Fordyce on the shaft of the penis masquerading as keratoacanthoma. ( 26312700 )
2015
47
Unique subungueal keratoacanthoma revealing incontinentia pigmenti. ( 26387562 )
2015
48
Don't miss the base - keratoacanthoma-type squamous cell carcinoma with perineural invasion during BRAF inhibitor therapy for melanoma. ( 26612802 )
2015
49
Expression of Cyclooxygenase-2 in Squamous Cell Carcinoma and Keratoacanthoma and its Clinical Significance. ( 25575894 )
2015
50
Keratoacanthoma of the Lip: Activation of the mTOR Pathway, Tumor Suppressor Proteins, and Tumor Senescence. ( 26402814 )
2015

Variations for Keratoacanthoma

Expression for Keratoacanthoma

Search GEO for disease gene expression data for Keratoacanthoma.

Pathways for Keratoacanthoma

Pathways related to Keratoacanthoma according to GeneCards Suite gene sharing:

(show all 18)
id Super pathways Score Top Affiliating Genes
1 12.43 CDKN1A MLH1 MSH2 TP53
2
Show member pathways
12.11 CDKN1A MLH1 MSH2 TP53
3 12.02 CDKN1A MKI67 MLH1 MSH2 TP53
4 11.99 CDKN1A GZMB TP53
5 11.92 CDKN1A MLH1 MSH2 TP53
6
Show member pathways
11.81 DSG1 FLG KRT10 KRT16 KRT17
7 11.75 CDKN1A MLH1 MSH2 TP53
8 11.68 CDKN1A MLH1 MSH2 TP53
9 11.63 CDKN1A RBP1 TP53
10 11.58 CDKN1A KRT17 TP53
11 11.27 CDKN1A MSH2 TP53
12
Show member pathways
11.15 MLH1 MSH2 TP53
13 11.08 CDKN1A TP53
14 11.03 MLH1 MSH2
15
Show member pathways
10.89 CDKN1A TP53
16 10.79 CDKN1A MLH1 MSH2 TP53
17 10.6 CDKN1A TP53
18
Show member pathways
10.38 CDKN1A TP53

GO Terms for Keratoacanthoma

Cellular components related to Keratoacanthoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.81 CDKN1A DSG1 FLG GZMB KRT10 KRT16
2 condensed chromosome GO:0000793 9.26 MKI67 MLH1
3 cornified envelope GO:0001533 9.13 DSG1 FLG KRT10
4 intermediate filament GO:0005882 8.92 FLG KRT10 KRT16 KRT17

Biological processes related to Keratoacanthoma according to GeneCards Suite gene sharing:

(show all 25)
id Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.88 CDKN1A MLH1 MSH2 TP53
2 cell cycle arrest GO:0007050 9.75 CDKN1A MSH2 TP53
3 keratinization GO:0031424 9.67 DSG1 KRT10 KRT16 KRT17
4 keratinocyte differentiation GO:0030216 9.63 FLG KRT10 KRT16
5 positive regulation of reactive oxygen species metabolic process GO:2000379 9.62 CDKN1A TP53
6 cellular response to ionizing radiation GO:0071479 9.62 CDKN1A TP53
7 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.61 GZMB TP53
8 intrinsic apoptotic signaling pathway GO:0097193 9.61 CDKN1A TP53
9 meiotic nuclear division GO:0007126 9.6 MKI67 MLH1
10 cellular response to gamma radiation GO:0071480 9.59 CDKN1A TP53
11 establishment of skin barrier GO:0061436 9.57 FLG KRT16
12 isotype switching GO:0045190 9.56 MLH1 MSH2
13 somatic hypermutation of immunoglobulin genes GO:0016446 9.55 MLH1 MSH2
14 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.54 CDKN1A TP53
15 determination of adult lifespan GO:0008340 9.52 MSH2 TP53
16 replicative senescence GO:0090399 9.51 CDKN1A TP53
17 positive regulation of isotype switching to IgG isotypes GO:0048304 9.49 MLH1 MSH2
18 skin epidermis development GO:0098773 9.48 FLG KRT10
19 positive regulation of isotype switching to IgA isotypes GO:0048298 9.43 MLH1 MSH2
20 signal transduction by p53 class mediator GO:0072331 9.4 CDKN1A TP53
21 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.33 CDKN1A MSH2 TP53
22 somatic recombination of immunoglobulin gene segments GO:0016447 9.32 MLH1 MSH2
23 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.26 MLH1 MSH2
24 response to X-ray GO:0010165 9.13 CDKN1A MSH2 TP53
25 cornification GO:0070268 9.02 DSG1 FLG KRT10 KRT16 KRT17

Molecular functions related to Keratoacanthoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural constituent of epidermis GO:0030280 9.16 FLG KRT10
2 mismatched DNA binding GO:0030983 8.96 MLH1 MSH2
3 guanine/thymine mispair binding GO:0032137 8.62 MLH1 MSH2

Sources for Keratoacanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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