MCID: KRT005
MIFTS: 53

Keratoacanthoma malady

Summaries for Keratoacanthoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) skin tumour that is... more...

MalaCards: Keratoacanthoma is related to squamous cell carcinoma and muir-torre syndrome. An important gene associated with Keratoacanthoma is KRT10 (keratin 10), and among its related pathways are Lagging Strand Synthesis and Matrix Metalloproteinases. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and bone, and related mouse phenotypes are limbs/digits/tail and integument.

Aliases & Classifications for Keratoacanthoma

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8Disease Ontology, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

keratoacanthoma 8 44 60


External Ids:

Disease Ontology8 DOID:3149
NCIt39 C3146
MeSH34 D007636

Related Diseases for Keratoacanthoma

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17GeneCards, 18GeneDecks
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Diseases in the Familial Keratoacanthoma family:

keratoacanthoma

Diseases related to Keratoacanthoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.3CRABP1, MKI67, MMP10, MMP19, NME1
2muir-torre syndrome30.5MLH1, MSH2
3basal cell carcinoma30.4KRT17, KRT10, KRT16, MMP13, MKI67, BAK1
4melanoma30.4BAK1, MLH1, AREG, GZMB, MKI67, CDKN1A
5keratosis30.3IVL, KRT16, KRT10
6lichen planus30.3GZMB, IVL, DSG3, KRT16, KRT10
7papilloma30.1AREG, IVL, BAK1, CDKN1A, PCNA, KRT10
8psoriasis30.1KRT17, KRT10, KRT16, MMP19, BAK1, IVL
9cervical squamous cell carcinoma30.0MLH1, IVL, MKI67, CDKN1A, KRT10
10adenocarcinoma30.0IVL, MLH1, AREG, DSG3, BAK1, MSH2
11skin melanoma29.7NME1
12sarcoma29.7MSH2, MKI67, MLH1
13arthritis29.7GZMB, MMP13, MMP10
14chondrosarcoma29.7MMP13
15dermatitis29.7KRT16, DSG3, IVL, GZMB
16rheumatoid arthritis29.7GZMB, AREG, MMP13, MMP19
17bladder carcinoma29.7AREG, MKI67, CDKN1A, PCNA
18lung cancer29.7IVL, BAK1, CDKN1A, PCNA, NME1
19transitional cell carcinoma29.7MLH1, MKI67, CDKN1A, PCNA, NME1, MSH2
20skin disease29.7AREG, CRABP2, IVL, DSG3, KRT16, KRT10
21myeloma29.7CDKN1A, BAK1, AREG
22leukemia29.7GZMB, AREG, MLH1, IVL, BAK1, CDKN1A
23skin squamous cell carcinoma10.5
24lupus erythematosus10.2
25verrucous carcinoma10.1
26in situ carcinoma10.1
27familial keratoacanthoma10.1
28actinic keratosis10.1
29cutaneous lupus erythematosus10.0
30vulvar keratoacanthoma-like carcinoma10.0
31sporotrichosis10.0
32vitiligo10.0
33cervicitis10.0
34multiple self-healing squamous epithelioma, susceptiblity to10.0
35gingivitis10.0MMP13
36hepatitis10.0GZMB
37gallbladder cancer10.0MLH1
38severe combined immunodeficiency10.0CD3D
39tongue cancer10.0CDKN1A
40malignant mesothelioma10.0AREG
41gastrointestinal stromal tumor10.0PCNA, MKI67
42neuroblastoma10.0NME1
43wilms tumor10.0AREG
44deficiency anemia10.0AREG
45sebaceous adenoma10.0MSH2
46epidermolytic hyperkeratosis10.0KRT16, KRT10
47teratocarcinoma10.0CRABP1
48gastritis10.0PCNA, AREG
49monilethrix10.0KRT17, KRT16
50cystadenocarcinoma10.0AREG

Graphical network of the top 20 diseases related to Keratoacanthoma:



Diseases related to keratoacanthoma

Clinical Features for Keratoacanthoma

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Drugs & Therapeutics for Keratoacanthoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Keratoacanthoma

Drug clinical trials:

Search ClinicalTrials for Keratoacanthoma

Search NIH Clinical Center for Keratoacanthoma

Search CenterWatch for Keratoacanthoma

Genetic Tests for Keratoacanthoma

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Anatomical Context for Keratoacanthoma

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32MalaCards
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MalaCards organs/tissues related to Keratoacanthoma:

32
Skin, Lung, Bone, Colon, Smooth muscle, Myeloid, Bone marrow, Testes, Lymph node, Tongue, Cervix

Animal Models for Keratoacanthoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Keratoacanthoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.2CRABP2
2MP:001077110.0KRT17, KRT16, NME1, MMP13, CDKN1A, DSG3
3MP:000200610.0MSH2, MMP19, CDKN1A, MLH1, GZMB, KRT10
4MP:00053779.8KRT10, CRABP2, CRABP1
5MP:00053819.8AREG, MSH2, DSG3, CDKN1A, KRT16, KRT17
6MP:00053979.7MSH2, NME1, PCNA, CD3D, GZMB, DSG3
7MP:00053849.6GZMB, MLH1, DSG3, BAK1, CDKN1A, PCNA
8MP:00053879.6MMP10, MSH2, KRT10, BAK1, PCNA, CD3D
9MP:00107689.4BAK1, DSG3, CRABP2, CRABP1, GZMB, CDKN1A

Publications for Keratoacanthoma

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50PubMed
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Articles related to Keratoacanthoma:

(show top 50)    (show all 524)
idTitleAuthorsYear
1
Keratoacanthoma and other types of squamous cell carcinoma with crateriform architecture: classification and identification. (23414327)
2013
2
Photodynamic therapy for multiple eruptive keratoacanthomas associated with vemurafenib treatment for metastatic melanoma. (22431777)
2012
3
Keratoacanthoma arising in nevus comedonicus. (22863626)
2012
4
Recurrent distal digital keratoacanthoma of the periungual region treated with Mohs micrographic surgery. (22309347)
2012
5
Verrucous cell carcinoma arising from an underlying giant keratoacanthoma. (22561523)
2012
6
Successful treatment of multiple keratoacanthoma with topical imiquimod and low-dose acitretin. (21544945)
2011
7
Refractory aggressive keratoacanthoma centrifugum marginatum of the scalp controlled with the epidermal growth factor receptor inhibitor erlotinib. (20222923)
2010
8
Keratoacanthoma centrifugum marginatum: a rare variant of keratoacanthoma. (20128993)
2010
9
Keratoacanthoma like secondaries on the scalp. (19736445)
2009
10
Giant keratoacanthoma of the upper extremity treated with mohs micrographic surgery: a case report and review of current treatment modalities. (20729950)
2009
11
Solitary subungual keratoacanthoma arising in an MSH2 germline mutation carrier: confirmation of a relationship by immunohistochemical analysis. (19602866)
2009
12
Keratoacanthoma of the gingiva--a pathological conundrum. (18485793)
2009
13
Expression of apoptotic and cell proliferation regulatory proteins in keratoacanthomas and squamous cell carcinomas of the skin. (18079070)
2008
14
Subungual keratoacanthoma: ultrasound and magnetic resonance imaging findings. (17380331)
2007
15
Keratoacanthoma causing beak deformity in a budgerigar (Melopsittacus undulatus). (17994330)
2007
16
Keratoacanthoma arising after an arthropod sting. (17198530)
2006
17
Giant clear-cell acanthoma with keratoacanthoma-like changes: a case report. (17083866)
2006
18
Periocular keratoacanthoma: can we always rely on the clinical diagnosis? (16113382)
2005
19
Analysis of loss of heterozygosity in Korean patients with keratoacanthoma. (15832014)
2005
20
Keratoacanthoma-like squamous cell carcinoma within the fibroepithelial polyp. (14871233)
2004
21
Conjunctival keratoacanthoma in an Asian. (12523897)
2003
22
Keratoacanthoma: is it a real entity? (9600429)
1998
23
Immunohistochemical staining for desmogleins 1 and 2 in keratinocytic neoplasms with squamous phenotype: actinic keratosis, keratoacanthoma and squamous cell carcinoma of the skin. (9579833)
1998
24
Keratoacanthoma: a clinically distinct variant of well differentiated squamous cell carcinoma. (10021894)
1998
25
Keratoacanthoma developing in prurigo nodularis treated with cryotherapy. (9187853)
1997
26
Multiple keratoacanthomas, giant keratoacanthoma and keratoacanthoma centrifugum marginatum: development in a single patient and treatment with oral isotretinoin. (8721490)
1996
27
Microsatellite instability in keratoacanthoma. (8625045)
1995
28
p53 expression in pseudoepitheliomatous hyperplasia, keratoacanthoma, and squamous cell carcinoma of skin. (8168036)
1994
29
Subungual keratoacanthoma. (7982683)
1994
30
Keratoacanthoma in Kauai, Hawaii. The first documented incidence in a defined population. (8447667)
1993
31
'Anti-metastatic' nm23 gene product expression in keratoacanthoma and squamous cell carcinoma. (8358113)
1993
32
DNA image cytometry of keratoacanthoma and squamous cell carcinoma. (1875048)
1991
33
Solitary keratoacanthoma of the nasal vestibule. (2026949)
1991
34
Keratoacanthoma arising within organoid naevi. (2025939)
1991
35
Utility of peanut agglutinin (PNA) in the diagnosis of squamous cell carcinoma and keratoacanthoma. (2180338)
1990
36
Multiple keratoacanthomas and junctional epidermolysis bullosa. A therapeutic conundrum. (2310205)
1990
37
Human papillomavirus associated with keratoacanthoma. (2554820)
1989
38
Keratoacanthoma of the limbus. (3362498)
1988
39
Keratoacanthomas associated with cervical squamous cell carcinoma. (4004294)
1985
40
A case of eruptive keratoacanthoma treated by oral etretinate. (4005156)
1985
41
Giant keratoacanthoma of the nose. (3920608)
1985
42
Keratoacanthoma of the vulva. (3988123)
1985
43
Keratoacanthoma arising in stasis dermatitis. (6662256)
1983
44
Squamous-cell carcinoma vs. keratoacanthoma. (7096765)
1982
45
Keratoacanthoma as a complication of arterial puncture for blood gases. (7118351)
1982
46
Spontaneous regression of a giant keratoacanthoma. Photographic documentation and histopathologic correlation. (7309976)
1981
47
Multiple keratoacanthomas associated with steatocystoma multiplex and rheumatoid arthritis. A case report. (7406520)
1980
48
Keratoacanthoma of the glans penis. (520038)
1979
49
Keratoacanthoma of nailbed: a report of two cases. (4704160)
1973
50
Actinic keratoacanthoma. (4639249)
1972

Genetic Variations for Keratoacanthoma

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Expression for genes affiliated with Keratoacanthoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratoacanthoma

Search GEO for disease gene expression data for Keratoacanthoma.

Pathways for genes affiliated with Keratoacanthoma

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53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Keratoacanthoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3MSH2, MLH1
2
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10.2MMP19, MMP10, MMP13
3
Cell adhesion ECM remodeling
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10.2MMP19, MMP10, MMP13
4
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10.2MMP13, MMP10, MMP19
5
DNA damage Role of Brca1 and Brca2 in DNA repair
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10.2MLH1, PCNA, MSH2
6
Hide members
10.1MLH1, CDKN1A, PCNA, MSH2
710.0MSH2, PCNA, CDKN1A, BAK1, MLH1
8
Hide members
10.0MLH1, MKI67, CDKN1A, PCNA, MSH2
9
Hide members
10.0GZMB, DSG3, BAK1, CDKN1A, PCNA
10
Hide members
9.9MMP19, MMP10, MMP13, CD3D, CDKN1A, AREG

Compounds for genes affiliated with Keratoacanthoma

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB
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Compounds related to Keratoacanthoma according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8IVL
2cycloheximide4410.6CRABP2
3etoposide44 49 59 1113.6BAK1, MLH1, GZMB
4dithranol4410.5IVL, KRT10, KRT16
5chi 24410.5NME1, MKI67, MLH1
6calcipotriol44 59 28 1113.5KRT10, KRT16, IVL
7temozolomide44 1111.5MLH1, CDKN1A, MSH2, PCNA
8gm 60015910.5MMP13, MMP19, MMP10
9mnng4410.5MSH2, PCNA, MLH1
10acitretin44 1111.5KRT17, IVL, CRABP1
11uk 3833675910.5MMP13, MMP10, MMP19
12gi 254023x5910.5MMP13, MMP10, MMP19
13isotretinoin44 1111.5KRT10, MKI67, CRABP1, KRT16
14sodium dodecylsulfate4410.4KRT17, KRT16, IVL, CRABP2
15dutp4410.4PCNA, KRT10, MKI67, BAK1
16o6-methylguanine4410.4MSH2, MLH1, PCNA
17hematoxylin4410.4MKI67, KRT10, PCNA, IVL
18irinotecan44 49 1112.4CDKN1A, MLH1, BAK1, MKI67
19celecoxib44 59 28 49 11 2415.4MKI67, BAK1, CDKN1A, PCNA
20biotin44 11 2412.4MSH2, MLH1, MKI67, PCNA, NME1
21thymidylate4410.4MKI67, MLH1, CDKN1A, PCNA, MSH2
22paclitaxel44 49 1112.3MLH1, BAK1, CDKN1A
23steroid4410.3CRABP2, MKI67, NME1, KRT16, KRT10, GZMB
24p0024410.3MLH1, MKI67, MMP13, NME1
25marimastat44 59 1112.3MMP10, MMP19, MMP13
26gf 109203x44 5911.3IVL, CDKN1A, KRT10, MMP13
27bromodeoxyuridine4410.3MLH1, IVL, MKI67, CDKN1A, PCNA, KRT10
28dexamethasone44 49 28 1113.3NME1, PCNA, BAK1, MMP13, AREG, GZMB
29fatty acid4410.3CRABP2, MLH1, IVL, NME1, KRT10, CRABP1
30calcitriol44 59 11 2413.2KRT16, BAK1, KRT10, NME1, CDKN1A, AREG
3112-o-tetradecanoylphorbol 13-acetate4410.2MMP10, GZMB, AREG, MMP13, CDKN1A, BAK1
32agarose4410.1MLH1, CDKN1A, GZMB, MMP13
33progesterone44 59 28 11 2414.1MLH1, MKI67, CDKN1A, PCNA, KRT10, AREG
34crcs4410.1MSH2, MLH1, NME1
355fluorouracil4410.1MKI67, MSH2, BAK1, IVL, CDKN1A, PCNA
36thymidine44 2411.1PCNA, MMP13, MKI67, IVL, MLH1, AREG
37proline4410.1CRABP1, MSH2, CRABP2, MLH1, MKI67, KRT16
38camptothecin44 59 1112.1PCNA, BAK1, CDKN1A, MLH1
39oxygen44 2411.0BAK1, MKI67, CDKN1A, MMP13, IVL
40oligonucleotide4410.0GZMB, IVL, CDKN1A, PCNA, MMP10, NME1
41arginine4410.0MKI67, MLH1, CRABP2, PCNA, KRT10, CRABP1
42cisplatin44 49 59 1113.0GZMB, MSH2, NME1, PCNA, CDKN1A, MLH1
43retinoid4410.0IVL, CRABP2, MMP13, CDKN1A, KRT16, KRT10
44serine4410.0NME1, MMP10, MMP13, MKI67, DSG3, KRT17
45vegf449.9IVL, PCNA, MLH1, AREG, GZMB, MKI67
46calcium44 49 11 2412.8IVL, AREG, KRT10, DSG3, CRABP1, GZMB
47tyrosine449.8KRT17, NME1, MMP13, CDKN1A, MKI67, BAK1
48paraffin449.7MSH2, MMP13, NME1, KRT16, KRT10, KRT17
49doxorubicin44 49 1111.7BAK1, CDKN1A, MLH1, MKI67, MSH2
50retinoic acid44 2410.4MKI67, BAK1, MLH1, CRABP2, CRABP1, AREG

GO Terms for genes affiliated with Keratoacanthoma

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16Gene Ontology
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Cellular components related to Keratoacanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.2KRT17, KRT10, KRT16
2PCNA-p21 complexGO:07055710.0PCNA, CDKN1A

Biological processes related to Keratoacanthoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:00629810.4MSH2, PCNA, MLH1
2intrinsic apoptotic signaling pathwayGO:09719310.4BAK1, CDKN1A, GZMB
3organ regenerationGO:03110010.4BAK1, MKI67, CDKN1A
4response to UV-BGO:01022410.4IVL, MSH2
5negative regulation of gene expressionGO:01062910.3CDKN1A, BAK1, NME1
6collagen catabolic processGO:03057410.3MMP13, MMP10, MMP19
7isotype switchingGO:04519010.3MSH2, MLH1
8epidermis developmentGO:00854410.2CRABP2, KRT17, KRT16
9extracellular matrix disassemblyGO:02261710.1MMP13, MMP10, MMP19
10somatic hypermutation of immunoglobulin genesGO:01644610.0MSH2, MLH1

Molecular functions related to Keratoacanthoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1guanine/thymine mispair bindingGO:03213710.5MLH1, MSH2
2dinucleotide insertion or deletion bindingGO:03213910.4PCNA, MSH2
3MutLalpha complex bindingGO:03240510.4PCNA, MSH2
4retinoid bindingGO:00550110.3CRABP2, CRABP1
5single-stranded DNA bindingGO:00369710.2MSH2, MLH1, NME1
6metalloendopeptidase activityGO:00422210.2MMP13, MMP10, MMP19
7retinal bindingGO:01691810.1CRABP2, CRABP1
8retinol bindingGO:0198419.9CRABP2, CRABP1

Products for genes affiliated with Keratoacanthoma

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  • Antibodies
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Sources for Keratoacanthoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet