MCID: KRT005
MIFTS: 39

Keratoacanthoma malady

Genetic diseases, Cancer diseases, Eye diseases, Skin diseases, Rare diseases categories

Aliases & Classifications for Keratoacanthoma

About this section
Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 65UMLS, 36MeSH, 59SNOMED-CT, 42NCIt
See all sources

Aliases & Descriptions for Keratoacanthoma:

Name: Keratoacanthoma 10 47 12 65 36


Classifications:



External Ids:

Disease Ontology10 DOID:3149
NCIt42 C3146
MeSH36 D007636

Summaries for Keratoacanthoma

About this section
MalaCards based summary: Keratoacanthoma is related to steatocystoma multiplex and anaplastic large cell lymphoma. An important gene associated with Keratoacanthoma is KRT10 (Keratin 10, Type I), and among its related pathways are Platinum Pathway, Pharmacokinetics/Pharmacodynamics and Doxorubicin Pathway, Pharmacokinetics. Affiliated tissues include skin, bone and lung, and related mouse phenotypes are craniofacial and tumorigenesis.

Related Diseases for Keratoacanthoma

About this section

Diseases in the Keratoacanthoma family:

Familial Keratoacanthoma

Diseases related to Keratoacanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1steatocystoma multiplex30.2KRT16, KRT17
2anaplastic large cell lymphoma29.9MLH1, MSH2
3skin tag29.9KRT10, MSH2, TP53
4generalized eruptive keratoacanthoma10.6
5basal cell carcinoma10.5
6muir-torre syndrome10.4
7melanoma10.4
8lichen planus10.3
9keratosis10.3
10lupus erythematosus10.3
11familial keratoacanthoma10.3
12brain germinoma10.3MKI67, TP53
13central nervous system leiomyosarcoma10.3MKI67, TP53
14splenogonadal fusion limb defects micrognatia10.3MKI67, TP53
15vulvar seborrheic keratosis10.3MKI67, TP53
16oral lichen planus10.3MKI67, TP53
17lichtenstein syndrome10.3GZMB, TP53
18steatitis10.3MKI67, TP53
19ethmoid sinus ectopic meningioma10.3KRT17, TP53
20embryonal tumor with multilayered rosettes10.2MKI67, TP53
21discoid lupus erythematosus10.2
22ichthyosis, cyclic, with epidermolytic hyperkeratosis10.2KRT10, KRT16
23mikulicz disease10.2GZMB, MKI67, TP53
24bladder urachal carcinoma10.2CDKN1A, TP53
25inverted follicular keratosis10.2CDKN1A, TP53
26selective iga deficiency disease10.2CDKN1A, TP53
27cystitis10.2KRT10, TP53
28testis refractory cancer10.2CDKN1A, TP53
29angioedema10.2MLH1, TP53
30tongue cancer10.2KRT16, KRT17
31lip cancer10.2DSG1, GZMB, TP53
32vulvar keratoacanthoma-like carcinoma10.2
33actinic keratosis10.2
34papilloma10.2
35psoriasis10.2
36high molecular weight kininogen deficiency10.2MKI67, TP53
37keratosis, seborrheic, somatic10.2KRT10, RBP1, TP53
38echinococcosis10.2KRT15, TP53
39familiar ovarian carcinoma10.2KRT16, KRT17
40palmoplantar keratoderma, epidermolytic10.1KRT16, KRT17
41vulvar granular cell tumor10.1GZMB, TP53
42glossopharyngeal nerve disease10.1KRT16, KRT17
43vulvar clear cell hidradenocarcinoma10.1KRT10, KRT15
44acute gonococcal cystitis10.1KRT10, KRT16, TP53
45lung leiomyosarcoma10.1MKI67, TP53
46pigmented basal cell carcinoma10.1KRT15, TP53
47fallopian tube squamous cell carcinoma10.1MLH1, TP53
48maculopapular lupus rash10.1GZMB, KRT10, KRT16
49cholesterol embolism10.1KRT10, KRT16, MKI67
50bronchogenic lung adenocarcinoma10.1CDKN1A, KRT10, TP53

Graphical network of the top 20 diseases related to Keratoacanthoma:



Diseases related to keratoacanthoma

Symptoms for Keratoacanthoma

About this section

Drugs & Therapeutics for Keratoacanthoma

About this section

Drugs for Keratoacanthoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DabrafenibapprovedPhase 26544462760, 44516822
Synonyms:
BRAF inhibitor GSK2118436
Dabrafenib
Dabrafenib Mesylate
 
GSK2118436
GSK2118436a
Tafinlar
dabrafenib
2
TrametinibapprovedPhase 2103871700-17-311707110
Synonyms:
GSK 1120212
GSK1120212
JTP 74057
JTP-74057
 
MEK Inhibitor GSK1120212
Mekinist
Trametinib Dimethyl Sulfoxide
Trametinibum
trametinib
3
Sorafenibapproved, investigational653284461-73-0216239, 406563
Synonyms:
284461-73-0
4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide
4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide
4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate
4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide
4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE
AB1004622
AC-1674
AC1L50CF
BAX
BAY 43-9006
BAY 43-9006 (free base)
BAY 43-9006 tosylate salt
BAY 439006
BAY 54-9085 (tosylate salt)
BAY-43-0006
BAY-43-9006
BAY-54-9085
BAY43-9006
BRD-K23984367-001-01-8
Bio-0100
CHEBI:47228
CHEBI:50924
CHEMBL1336
CID216239
 
D08524
DB00398
DB07438
EN002709
I06-0856
K00597a
Kinome_766
LS-186067
LS-187021
LS-187788
MolPort-003-850-270
N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea
N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea
NCGC00167488-01
NSC-724772
NSC747971
Nexavar
STK627350
Sorafenib
Sorafenib (INN)
Sorafenib Tosylate
Sorafenib [INN]
Sorafenib tosylate
Sorafenibum
UNII-9ZOQ3TZI87
ZINC01493878
nchembio.117-comp17
sorafenib
sorafenibum

Interventional clinical trials:

idNameStatusNCT IDPhase
1Phase II Biomarker Study Comparing the Combination of BRAF Inhibitor Dabrafenib With MEK Inhibitor Trametinib Versus the Combination After Monotherapy With Dabrafenib or TrametinibRecruitingNCT02314143Phase 2
2A Pilot Study of Trientine With Vemurafenib for the Treatment BRAF Mutated Metastatic MelanomaWithdrawnNCT02068079Phase 1
3Prospective, Non-interventional, Post-authorization Safety Study That Includes All Patients Diagnosed as Unresectable Differentiated Thyroid Carcinoma and Treated With SorafenibRecruitingNCT02185560

Search NIH Clinical Center for Keratoacanthoma


Cochrane evidence based reviews: Keratoacanthoma

Genetic Tests for Keratoacanthoma

About this section

Anatomical Context for Keratoacanthoma

About this section

MalaCards organs/tissues related to Keratoacanthoma:

33
Skin, Bone, Lung, Colon, Testes, Cervix, Myeloid

Animal Models for Keratoacanthoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Keratoacanthoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.2CDKN1A, KRT10, KRT16, KRT17, TP53
2MP:00020068.0CDKN1A, GZMB, KRT10, MLH1, MSH2, TP53
3MP:00053817.6CDKN1A, KRT16, KRT17, MLH1, MSH2, TP53
4MP:00107717.0CDKN1A, KRT10, KRT16, KRT17, MLH1, MSH2

Publications for Keratoacanthoma

About this section

Articles related to Keratoacanthoma:

(show top 50)    (show all 572)
idTitleAuthorsYear
1
Recurrent facial keratoacanthoma in a patient with diabetes: a case report. (24758418)
2014
2
Keratoacanthoma accompanied by multiple lung squamous cell carcinomas developing in a renal transplant recipient. (25120468)
2014
3
Plasmacytoid dendritic cell involvement in the host response against keratoacanthoma. (24831321)
2014
4
Metastatic laryngeal carcinoma mimicking eruptive keratoacanthomas: report of keratoacanthoma-like cutaneous metastases in a radiation port. (25244165)
2014
5
Keratoacanthoma with secondary ossification. (23231325)
2014
6
Generalized eruptive keratoacanthoma: a diagnostic and therapeutic challenge. (25070745)
2014
7
Ki-67 may be useful in differentiating between keratoacanthoma and cutaneous squamous cell carcinoma. (24524559)
2014
8
Two rare variants of keratoacanthoma in the same sign-out session. (24117878)
2013
9
Keratoacanthoma: an unusual nasal mass. (24376301)
2013
10
Spontaneous involution of keratoacanthoma, iconographic documentation and similarity with volcanoes of nature. (22570051)
2012
11
The nuclear factor kappa B p50 subunit and cortactin as markers to distinguish between keratoacanthoma and well-differentiated squamous cell carcinoma. (21883393)
2011
12
Keratoacanthoma of the head and neck with perineural invasion: incidental finding or cause for concern? (20653733)
2010
13
Cutaneous lupus erythematosus mimicking multiple keratoacanthomas. (19106056)
2009
14
Keratoacanthoma in a tattoo. (19903437)
2009
15
PGP 9.5 expression in cutaneous keratoacanthomas and squamous cell carcinomas. (19488775)
2009
16
A case of multiple keratoacanthomas associated with keratoacanthoma centrifugum marginatum. (16648927)
2006
17
HPV 6-positive giant keratoacanthoma in an immunocompetent patient. (16683389)
2006
18
Intralesional methotrexate for keratoacanthoma of the nose. (16276163)
2005
19
Imiquimod as a possible treatment for keratoacanthoma. (14964750)
2004
20
Multiple, keratoacanthoma-like nodules on a 47-year-old man: a rare presentation of cutaneous lupus erythematosus. (14636190)
2003
21
Keratoacanthoma developing on a pigmented patch in incontinentia pigmenti. (10828638)
2000
22
Malignant changes in a giant orbital keratoacanthoma developing over 25 years. (10794263)
2000
23
Multiple keratoacanthoma with neonatal onset in a girl. (10627223)
1999
24
Persistent keratoacanthoma: challenges in management. (9865205)
1998
25
Cutaneous sporotrichosis presenting as a keratoacanthoma. (9675531)
1998
26
Keratoacanthoma: is it a real entity? (9600429)
1998
27
Keratoacanthomas and lymphomatoid papulosis. (9700388)
1998
28
Generalized eruptive keratoacanthoma of Grzybowski: response to cyclophosphamide. (9146546)
1997
29
Microsatellite instability in keratoacanthoma. (8625045)
1995
30
Keratoacanthoma versus squamous cell carcinoma. An immunohistochemical reappraisal of p53 protein and proliferating cell nuclear antigen expression in keratoacanthoma-like tumors. (8600793)
1995
31
Subungual keratoacanthoma masquerading as a chronic paronychia. (7702309)
1995
32
Eruptive skin tags and keratoacanthomas in a patient with prolactinoma and colonic polyposis. (8075462)
1994
33
Nature of keratoacanthoma. (7943646)
1994
34
Basal cell carcinoma and keratoacanthoma in Hawaiians: an incidence report. (8227552)
1993
35
Generalized eruptive keratoacanthoma of Grzybowski. (8340502)
1993
36
DNA image cytometry of keratoacanthoma and squamous cell carcinoma. (1875048)
1991
37
Keratoacanthoma versus squamous cell carcinoma of the lower lip. (2189352)
1990
38
Keratoacanthoma of the limbus. (3362498)
1988
39
Intralesional 5-fluorouracil for keratoacanthoma of the eyelid. (3154563)
1986
40
Is it skin cancer--or keratoacanthoma? (6468938)
1984
41
Treatment of keratoacanthoma with intralesional bleomycin. (6194810)
1983
42
Squamous-cell carcinoma vs. keratoacanthoma. (7096765)
1982
43
Hypocomplementemia in keratoacanthoma. (7247456)
1981
44
Keratoacanthoma of the head and neck. (7356269)
1980
45
Immune response to human keratoacanthoma. (394758)
1979
46
Conservative treatment of keratoacanthoma. (543623)
1979
47
Giant keratoacanthoma of the ear. (595076)
1977
48
Keratoacanthoma of the lower lip. Review of the literature and report of a case. (4531621)
1974
49
Epidermal antigens in experimental keratoacanthoma and squamous cell carcinoma. (4579775)
1973
50
Keratoacanthoma of nailbed: a report of two cases. (4704160)
1973

Variations for Keratoacanthoma

About this section

Expression for genes affiliated with Keratoacanthoma

About this section
Search GEO for disease gene expression data for Keratoacanthoma.

Pathways for genes affiliated with Keratoacanthoma

About this section

GO Terms for genes affiliated with Keratoacanthoma

About this section

Cellular components related to Keratoacanthoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1condensed chromosomeGO:00007939.8MKI67, MLH1
2intermediate filamentGO:00058828.4KRT10, KRT15, KRT16, KRT17

Biological processes related to Keratoacanthoma according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1somatic recombination of immunoglobulin genes involved in immune responseGO:000220410.4MLH1, MSH2
2somatic recombination of immunoglobulin gene segmentsGO:001644710.3MLH1, MSH2
3somatic hypermutation of immunoglobulin genesGO:001644610.3MLH1, MSH2
4mismatch repairGO:000629810.3MLH1, MSH2
5positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:190074010.2GZMB, TP53
6determination of adult lifespanGO:000834010.2MSH2, TP53
7isotype switchingGO:004519010.1MLH1, MSH2
8morphogenesis of an epitheliumGO:00020099.8KRT16, KRT17
9reciprocal meiotic recombinationGO:00071319.7MLH1, MSH2
10cellular response to ionizing radiationGO:00714799.6CDKN1A, TP53
11mitotic cell cycle arrestGO:00718509.4CDKN1A, TP53
12response to X-rayGO:00101659.3CDKN1A, MSH2, TP53
13positive regulation of reactive oxygen species metabolic processGO:20003799.3CDKN1A, TP53
14intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:00427719.3CDKN1A, MSH2, TP53
15epidermis developmentGO:00085449.3KRT15, KRT16, KRT17
16programmed cell deathGO:00125019.2DSG1, GZMB, TP53
17intrinsic apoptotic signaling pathwayGO:00971939.2CDKN1A, GZMB, TP53
18cell cycle arrestGO:00070509.0CDKN1A, MSH2, TP53
19cellular response to DNA damage stimulusGO:00069748.2CDKN1A, MLH1, MSH2, TP53

Molecular functions related to Keratoacanthoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mismatched DNA bindingGO:003098310.2MLH1, MSH2
2structural constituent of cytoskeletonGO:00052009.0KRT15, KRT16, KRT17
3structural molecule activityGO:00051988.4KRT10, KRT15, KRT16, KRT17

Sources for Keratoacanthoma

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet