MCID: KRT005
MIFTS: 44

Keratoacanthoma malady

Categories: Genetic diseases, Cancer diseases, Eye diseases, Skin diseases, Rare diseases

Aliases & Classifications for Keratoacanthoma

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Aliases & Descriptions for Keratoacanthoma:

Name: Keratoacanthoma 10 47 12 36 65

Classifications:



External Ids:

Disease Ontology10 DOID:3149
MeSH36 D007636
NCIt42 C3146
UMLS65 C0022572

Summaries for Keratoacanthoma

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Wikipedia:68 Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) skin tumour that is... more...

MalaCards based summary: Keratoacanthoma is related to muir-torre syndrome and hidradenitis, and has symptoms including skin manifestations, pruritus and exanthema. An important gene associated with Keratoacanthoma is KRT10 (Keratin 10), and among its related pathways are Platinum Pathway, Pharmacokinetics/Pharmacodynamics and Colorectal Cancer Metastasis. Affiliated tissues include skin, t cells and thyroid.

Related Diseases for Keratoacanthoma

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Diseases in the Keratoacanthoma family:

Familial Keratoacanthoma

Diseases related to Keratoacanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1muir-torre syndrome31.9MLH1, MSH2
2hidradenitis30.0DSG2, KRT10
3myeloid leukemia29.8KRT10, KRT16, MKI67
4molluscum contagiosum29.8MKI67, TP53
5generalized eruptive keratoacanthoma12.1
6familial keratoacanthoma12.1
7vulvar keratoacanthoma-like carcinoma11.9
8multiple self-healing squamous epithelioma, susceptiblity to11.3
9lymphatic system disease10.7MKI67, TP53
10vulvar clear cell hidradenocarcinoma10.7KRT10, TP53
11kidney leiomyosarcoma10.7MKI67, TP53
12splenogonadal fusion limb defects micrognatia10.7MKI67, TP53
13benign mesenchymoma10.7KRT10, TP53
14vulval paget's disease10.7MKI67, TP53
15vulva verrucous carcinoma10.7KRT10, TP53
16soft tissue sarcoma childhood10.6MKI67, TP53
17immune system cancer10.6MKI67, TP53
18osteoblastoma10.6MKI67, TP53
19vulvar granular cell tumor10.6GZMB, TP53
20small intestine leiomyosarcoma10.6MKI67, TP53
21autosomal dominant complex spastic paraplegia type 9a10.6MKI67, TP53
22small intestine cancer10.6GZMB, KRT10
23progressive muscular atrophy10.6MKI67, TP53
24sclerosteosis 110.5KRT10, KRT16
25fallopian tube transitional cell carcinoma10.5MKI67, TP53
26congenital structural myopathy10.4MLH1, TP53
27periodic limb movement disorder10.4GZMB, KRT10, TP53
28mucocele of salivary gland10.4GZMB, MKI67, TP53
29capillary lymphangioma10.4DSG2, KRT10
30histoplasmosis10.4FLG, TP53
31endometrial disease10.4DSG1, MKI67
32pemphigus vulgaris10.4DSG1, DSG2
33epilepsy benign neonatal dominant form10.4FLG, KRT10
34vulvar sarcoma10.4KRT10, TP53
35venous hemangioma10.3FLG, KRT10
36skin pilomatrix carcinoma10.3FLG, KRT10
37braddock syndrome10.3DSG1, FLG
38peri-anal fistula10.3DSG1, DSG2
39biliary tract neoplasm10.3MLH1, TP53
40clove syndrome, somatic10.3KRT10, RBP1, TP53
41colorectal adenomatous polyposis, autosomal recessive, with pilomatricomas10.3FLG, KRT10
42ichthyosis-hypotrichosis-sclerosing cholangitis syndrome10.3DSG1, DSG2
43ulnar neuropathy10.3MLH1, TP53
44contact dermatitis10.2FLG, KRT16
45inappropriate adh syndrome10.2DSG1, KRT16
46ichthyosis vulgaris10.2FLG, KRT10
47familial congenital fourth cranial nerve palsy10.2MSH2, TP53
48fanconi anemia, complementation group b10.2FLG, KRT10
49primary thrombocytopenia10.2MKI67, MLH1, TP53
50epidermolysis bullosa simplex, dowling-meara type10.2KRT10, KRT16

Graphical network of the top 20 diseases related to Keratoacanthoma:



Diseases related to keratoacanthoma

Symptoms for Keratoacanthoma

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UMLS symptoms related to Keratoacanthoma:


skin manifestations, pruritus, exanthema

Drugs & Therapeutics for Keratoacanthoma

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Drugs for Keratoacanthoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DabrafenibapprovedPhase 27044462760, 44516822
Synonyms:
BRAF inhibitor GSK2118436
Dabrafenib
Dabrafenib Mesylate
 
GSK2118436
GSK2118436a
Tafinlar
dabrafenib
2
TrametinibapprovedPhase 2111871700-17-311707110
Synonyms:
GSK 1120212
GSK1120212
JTP 74057
JTP-74057
 
MEK Inhibitor GSK1120212
Mekinist
Trametinib Dimethyl Sulfoxide
Trametinibum
trametinib
3Protein Kinase InhibitorsPhase 23162
4
Sorafenibapproved, investigational671284461-73-0216239, 406563
Synonyms:
284461-73-0
4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide
4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide
4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate
4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide
4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE
AB1004622
AC-1674
AC1L50CF
BAX
BAY 43-9006
BAY 43-9006 (free base)
BAY 43-9006 tosylate salt
BAY 439006
BAY 54-9085 (tosylate salt)
BAY-43-0006
BAY-43-9006
BAY-54-9085
BAY43-9006
BRD-K23984367-001-01-8
Bio-0100
CHEBI:47228
CHEBI:50924
CHEMBL1336
CID216239
 
D08524
DB00398
DB07438
EN002709
I06-0856
K00597a
Kinome_766
LS-186067
LS-187021
LS-187788
MolPort-003-850-270
N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea
N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea
NCGC00167488-01
NSC-724772
NSC747971
Nexavar
STK627350
Sorafenib
Sorafenib (INN)
Sorafenib Tosylate
Sorafenib [INN]
Sorafenib tosylate
Sorafenibum
UNII-9ZOQ3TZI87
ZINC01493878
nchembio.117-comp17
sorafenib
sorafenibum

Interventional clinical trials:

idNameStatusNCT IDPhase
1Phase II Biomarker Study Comparing the Combination of BRAF Inhibitor Dabrafenib With MEK Inhibitor Trametinib Versus the Combination After Monotherapy With Dabrafenib or TrametinibRecruitingNCT02314143Phase 2
2A Pilot Study of Trientine With Vemurafenib for the Treatment BRAF Mutated Metastatic MelanomaWithdrawnNCT02068079Phase 1
3Prospective, Non-interventional, Post-authorization Safety Study That Includes All Patients Diagnosed as Unresectable Differentiated Thyroid Carcinoma and Treated With SorafenibRecruitingNCT02185560

Search NIH Clinical Center for Keratoacanthoma


Cochrane evidence based reviews: keratoacanthoma

Genetic Tests for Keratoacanthoma

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Anatomical Context for Keratoacanthoma

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MalaCards organs/tissues related to Keratoacanthoma:

33
Skin, T cells, Thyroid, Small intestine, Breast, B cells, Lung

Animal Models for Keratoacanthoma or affiliated genes

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Publications for Keratoacanthoma

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Articles related to Keratoacanthoma:

(show top 50)    (show all 596)
idTitleAuthorsYear
1
Histopathological diagnosis of epithelial crateriform tumors: Keratoacanthoma and other epithelial crateriform tumors. (27076258)
2016
2
Sonographic features of keratoacanthoma. May ultrasound be a useful tool to differentiate it from squamous cell carcinoma? (26681149)
2016
3
Recurrent facial keratoacanthoma in a patient with diabetes: a case report. (24758418)
2014
4
Keratoacanthoma accompanied by multiple lung squamous cell carcinomas developing in a renal transplant recipient. (25120468)
2014
5
Plasmacytoid dendritic cell involvement in the host response against keratoacanthoma. (24831321)
2014
6
Metastatic laryngeal carcinoma mimicking eruptive keratoacanthomas: report of keratoacanthoma-like cutaneous metastases in a radiation port. (25244165)
2014
7
Keratoacanthoma with secondary ossification. (23231325)
2014
8
Generalized eruptive keratoacanthoma: a diagnostic and therapeutic challenge. (25070745)
2014
9
Two rare variants of keratoacanthoma in the same sign-out session. (24117878)
2013
10
Spontaneous involution of keratoacanthoma, iconographic documentation and similarity with volcanoes of nature. (22570051)
2012
11
Keratoacanthoma of the head and neck with perineural invasion: incidental finding or cause for concern? (20653733)
2010
12
Cutaneous lupus erythematosus mimicking multiple keratoacanthomas. (19106056)
2009
13
Keratoacanthoma in a tattoo. (19903437)
2009
14
A case of multiple keratoacanthomas associated with keratoacanthoma centrifugum marginatum. (16648927)
2006
15
HPV 6-positive giant keratoacanthoma in an immunocompetent patient. (16683389)
2006
16
Intralesional methotrexate for keratoacanthoma of the nose. (16276163)
2005
17
Imiquimod as a possible treatment for keratoacanthoma. (14964750)
2004
18
Multiple, keratoacanthoma-like nodules on a 47-year-old man: a rare presentation of cutaneous lupus erythematosus. (14636190)
2003
19
Keratoacanthoma developing on a pigmented patch in incontinentia pigmenti. (10828638)
2000
20
Malignant changes in a giant orbital keratoacanthoma developing over 25 years. (10794263)
2000
21
Multiple keratoacanthoma with neonatal onset in a girl. (10627223)
1999
22
Persistent keratoacanthoma: challenges in management. (9865205)
1998
23
Cutaneous sporotrichosis presenting as a keratoacanthoma. (9675531)
1998
24
Keratoacanthoma: is it a real entity? (9600429)
1998
25
Keratoacanthomas and lymphomatoid papulosis. (9700388)
1998
26
Generalized eruptive keratoacanthoma of Grzybowski: response to cyclophosphamide. (9146546)
1997
27
Microsatellite instability in keratoacanthoma. (8625045)
1995
28
Keratoacanthoma versus squamous cell carcinoma. An immunohistochemical reappraisal of p53 protein and proliferating cell nuclear antigen expression in keratoacanthoma-like tumors. (8600793)
1995
29
Subungual keratoacanthoma masquerading as a chronic paronychia. (7702309)
1995
30
Eruptive skin tags and keratoacanthomas in a patient with prolactinoma and colonic polyposis. (8075462)
1994
31
Nature of keratoacanthoma. (7943646)
1994
32
Basal cell carcinoma and keratoacanthoma in Hawaiians: an incidence report. (8227552)
1993
33
Generalized eruptive keratoacanthoma of Grzybowski. (8340502)
1993
34
DNA image cytometry of keratoacanthoma and squamous cell carcinoma. (1875048)
1991
35
Keratoacanthoma versus squamous cell carcinoma of the lower lip. (2189352)
1990
36
Keratoacanthoma of the limbus. (3362498)
1988
37
Intralesional 5-fluorouracil for keratoacanthoma of the eyelid. (3154563)
1986
38
Is it skin cancer--or keratoacanthoma? (6468938)
1984
39
Treatment of keratoacanthoma with intralesional bleomycin. (6194810)
1983
40
Squamous-cell carcinoma vs. keratoacanthoma. (7096765)
1982
41
Hypocomplementemia in keratoacanthoma. (7247456)
1981
42
Keratoacanthoma of the head and neck. (7356269)
1980
43
Successful treatment of keratoacanthoma with intralesional fluorouracil. (7364978)
1980
44
Immune response to human keratoacanthoma. (394758)
1979
45
Conservative treatment of keratoacanthoma. (543623)
1979
46
Giant keratoacanthoma of the ear. (595076)
1977
47
Keratoacanthoma of the lower lip. Review of the literature and report of a case. (4531621)
1974
48
Epidermal antigens in experimental keratoacanthoma and squamous cell carcinoma. (4579775)
1973
49
Keratoacanthoma of nailbed: a report of two cases. (4704160)
1973
50

Variations for Keratoacanthoma

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Expression for genes affiliated with Keratoacanthoma

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Search GEO for disease gene expression data for Keratoacanthoma.

Pathways for genes affiliated with Keratoacanthoma

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GO Terms for genes affiliated with Keratoacanthoma

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Biological processes related to Keratoacanthoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1somatic recombination of immunoglobulin genes involved in immune responseGO:000220410.3MLH1, MSH2
2somatic recombination of immunoglobulin gene segmentsGO:001644710.3MLH1, MSH2
3double-strand break repairGO:000630210.0MSH2, TP53
4intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:00427719.8MSH2, TP53
5response to progesteroneGO:00325709.4DSG1, DSG2
6establishment of skin barrierGO:00614369.4FLG, KRT16
7cellular response to DNA damage stimulusGO:00069749.0MLH1, MSH2, TP53

Molecular functions related to Keratoacanthoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1double-stranded DNA bindingGO:00036909.8MSH2, TP53

Sources for Keratoacanthoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet