MCID: KRT005
MIFTS: 46

Keratoacanthoma malady

Summaries for Keratoacanthoma

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Wikipedia:65 Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) skin tumour that is... more...

MalaCards based summary: Keratoacanthoma is related to muir-torre syndrome and basal cell carcinoma. An important gene associated with Keratoacanthoma is KRT10 (keratin 10), and among its related pathways are Granzyme Pathway and Telomere C-strand (Lagging Strand) Synthesis. The compounds isotretinoin and tcdd have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and bone, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Keratoacanthoma

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Sources:
10Disease Ontology, 45Novoseek, 62UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Keratoacanthoma, Aliases & Descriptions:

Name: Keratoacanthoma 10 45 62


External Ids:

Disease Ontology10 DOID:3149
MeSH35 D007636
NCIt40 C3146

Related Diseases for Keratoacanthoma

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Diseases related to Keratoacanthoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1muir-torre syndrome30.8MLH1, MSH2
2basal cell carcinoma30.5MKI67, MMP13, GZMB, KRT17, KRT10
3lichen planus30.5GZMB, KRT10
4melanoma30.4MLH1, MKI67, MMP13, MSH2, NME1, GZMB
5psoriasis30.2GZMB, KRT17, KRT10
6papilloma30.1KRT10
7laryngeal carcinoma30.1MKI67, NME1
8cervical squamous cell carcinoma30.1KRT10, MKI67, MLH1
9steatocystoma multiplex29.9KRT17, KRT10
10adenocarcinoma29.9MLH1, MKI67, MMP13, MSH2, NME1, KRT17
11sarcoma29.8MSH2, MKI67, MLH1
12transitional cell carcinoma29.8NME1, MSH2, MKI67, MLH1
13lung cancer29.8MLH1, MKI67, MMP13, NME1, GZMB
14leukemia29.8MLH1, MSH2, NME1, GZMB, KRT10
15generalized eruptive keratoacanthoma10.5
16keratosis10.3
17lupus erythematosus10.3
18discoid lupus erythematosus10.2
19actinic keratosis10.2
20vulvar keratoacanthoma-like carcinoma10.1
21cutaneous lupus erythematosus10.1
22verrucous carcinoma10.1
23sporotrichosis10.1
24cervicitis10.1
25laryngitis10.1
26multiple keratoacanthoma, ferguson-smith type10.1
27palmoplantar keratosis10.0KRT17, KRT10
28epidermolysis bullosa simplex10.0KRT10, KRT17
29sebaceous adenoma10.0MSH2
30peripheral t-cell lymphoma10.0GZMB, NME1
31endometrial cancer10.0NME1, MLH1
32breast cancer10.0MKI67, NME1
33leukoplakia10.0NME1, MKI67
34smooth muscle tumor10.0MKI67, NME1
35breast fibroadenoma10.0MKI67, NME1
36tongue squamous cell carcinoma10.0MKI67, NME1
37bladder cancer, somatic10.0KRT10, MKI67
38bowen syndrome10.0MKI67, KRT17, KRT10
39familial colorectal cancer10.0MSH2, MLH1
40mismatch repair cancer syndrome10.0MSH2, MLH1
41esophageal cancer10.0MMP13, NME1
42lynch syndrome10.0MLH1, MSH2
43sarcoma, synovial10.0MMP13, MKI67
44rectal neoplasm10.0MSH2, MLH1
45gastric adenocarcinoma10.0NME1, MMP13, MLH1
46squamous cell carcinoma, head and neck10.0MLH1, MMP13, NME1
47gallbladder cancer10.0NME1, MKI67, MLH1
48malignant fibroxanthoma10.0MSH2, MKI67
49laryngeal squamous cell carcinoma10.0NME1, MMP13, MKI67
50cervical cancer, somatic10.0MMP13, NME1, GZMB, KRT10

Graphical network of the top 20 diseases related to Keratoacanthoma:



Diseases related to keratoacanthoma

Symptoms for Keratoacanthoma

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Drugs & Therapeutics for Keratoacanthoma

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Drug clinical trials:

Search ClinicalTrials for Keratoacanthoma

Search NIH Clinical Center for Keratoacanthoma

Genetic Tests for Keratoacanthoma

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Anatomical Context for Keratoacanthoma

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MalaCards organs/tissues related to Keratoacanthoma:

33
Skin, Lung, Bone, Colon, Bone marrow, Lymph node, Testes, Cervix, Myeloid, Tongue

Animal Models for Keratoacanthoma or affiliated genes

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MGI Mouse Phenotypes related to Keratoacanthoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9MLH1, MSH2, NME1, GZMB, KRT10
2MP:00053847.8KRT17, GZMB, MSH2, MMP13, MLH1
3MP:00107717.4KRT10, KRT17, NME1, MSH2, MMP13, MLH1
4MP:00107687.2MLH1, MSH2, NME1, GZMB, KRT17, KRT10

Publications for Keratoacanthoma

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Articles related to Keratoacanthoma:

(show top 50)    (show all 549)
idTitleAuthorsYear
1
Recurrent facial keratoacanthoma in a patient with diabetes: a case report. (24758418)
2014
2
Keratoacanthoma accompanied by multiple lung squamous cell carcinomas developing in a renal transplant recipient. (25120468)
2014
3
Plasmacytoid dendritic cell involvement in the host response against keratoacanthoma. (24831321)
2014
4
Metastatic laryngeal carcinoma mimicking eruptive keratoacanthomas: report of keratoacanthoma-like cutaneous metastases in a radiation port. (25244165)
2014
5
Keratoacanthoma with secondary ossification. (23231325)
2014
6
Generalized eruptive keratoacanthoma: a diagnostic and therapeutic challenge. (25070745)
2014
7
Ki-67 may be useful in differentiating between keratoacanthoma and cutaneous squamous cell carcinoma. (24524559)
2014
8
Two rare variants of keratoacanthoma in the same sign-out session. (24117878)
2013
9
Keratoacanthoma: an unusual nasal mass. (24376301)
2013
10
Spontaneous involution of keratoacanthoma, iconographic documentation and similarity with volcanoes of nature. (22570051)
2012
11
The nuclear factor kappa B p50 subunit and cortactin as markers to distinguish between keratoacanthoma and well-differentiated squamous cell carcinoma. (21883393)
2011
12
Keratoacanthoma of the head and neck with perineural invasion: incidental finding or cause for concern? (20653733)
2010
13
Cutaneous lupus erythematosus mimicking multiple keratoacanthomas. (19106056)
2009
14
Keratoacanthoma in a tattoo. (19903437)
2009
15
PGP 9.5 expression in cutaneous keratoacanthomas and squamous cell carcinomas. (19488775)
2009
16
A case of multiple keratoacanthomas associated with keratoacanthoma centrifugum marginatum. (16648927)
2006
17
HPV 6-positive giant keratoacanthoma in an immunocompetent patient. (16683389)
2006
18
Intralesional methotrexate for keratoacanthoma of the nose. (16276163)
2005
19
Imiquimod as a possible treatment for keratoacanthoma. (14964750)
2004
20
Multiple, keratoacanthoma-like nodules on a 47-year-old man: a rare presentation of cutaneous lupus erythematosus. (14636190)
2003
21
Keratoacanthoma developing on a pigmented patch in incontinentia pigmenti. (10828638)
2000
22
Malignant changes in a giant orbital keratoacanthoma developing over 25 years. (10794263)
2000
23
Multiple keratoacanthoma with neonatal onset in a girl. (10627223)
1999
24
Persistent keratoacanthoma: challenges in management. (9865205)
1998
25
Cutaneous sporotrichosis presenting as a keratoacanthoma. (9675531)
1998
26
Keratoacanthoma: is it a real entity? (9600429)
1998
27
Keratoacanthomas and lymphomatoid papulosis. (9700388)
1998
28
Generalized eruptive keratoacanthoma of Grzybowski: response to cyclophosphamide. (9146546)
1997
29
Microsatellite instability in keratoacanthoma. (8625045)
1995
30
Keratoacanthoma versus squamous cell carcinoma. An immunohistochemical reappraisal of p53 protein and proliferating cell nuclear antigen expression in keratoacanthoma-like tumors. (8600793)
1995
31
Subungual keratoacanthoma masquerading as a chronic paronychia. (7702309)
1995
32
Eruptive skin tags and keratoacanthomas in a patient with prolactinoma and colonic polyposis. (8075462)
1994
33
Nature of keratoacanthoma. (7943646)
1994
34
Basal cell carcinoma and keratoacanthoma in Hawaiians: an incidence report. (8227552)
1993
35
Generalized eruptive keratoacanthoma of Grzybowski. (8340502)
1993
36
DNA image cytometry of keratoacanthoma and squamous cell carcinoma. (1875048)
1991
37
Keratoacanthoma of the limbus. (3362498)
1988
38
Intralesional 5-fluorouracil for keratoacanthoma of the eyelid. (3154563)
1986
39
Is it skin cancer--or keratoacanthoma? (6468938)
1984
40
Keratoacanthoma. A clinical study. (6721538)
1984
41
Treatment of keratoacanthoma with intralesional bleomycin. (6194810)
1983
42
Squamous-cell carcinoma vs. keratoacanthoma. (7096765)
1982
43
Hypocomplementemia in keratoacanthoma. (7247456)
1981
44
Successful treatment of keratoacanthoma with intralesional fluorouracil. (7364978)
1980
45
Immune response to human keratoacanthoma. (394758)
1979
46
Conservative treatment of keratoacanthoma. (543623)
1979
47
Giant keratoacanthoma of the ear. (595076)
1977
48
Keratoacanthoma of the lower lip. Review of the literature and report of a case. (4531621)
1974
49
Epidermal antigens in experimental keratoacanthoma and squamous cell carcinoma. (4579775)
1973
50
Keratoacanthoma of nailbed: a report of two cases. (4704160)
1973

Variations for Keratoacanthoma

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Expression for genes affiliated with Keratoacanthoma

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Search GEO for disease gene expression data for Keratoacanthoma.

Pathways for genes affiliated with Keratoacanthoma

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Compounds for genes affiliated with Keratoacanthoma

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Compounds related to Keratoacanthoma according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1isotretinoin45 1310.7MKI67, KRT10
2tcdd459.7MMP13, KRT10
3dutp459.6MKI67, KRT10
4p00001459.5MKI67, MLH1
5n-methyl-n-nitrosourea459.5MLH1, MSH2
6retinoid459.5KRT10, KRT17, MMP13
7glyceraldehyde 3-phosphate459.5KRT10, NME1, MMP13
8mononucleotide459.5MLH1, MSH2
96 thioguanine459.5MLH1, MSH2
10mnng459.4MLH1, MSH2
11agarose459.4MLH1, MMP13, GZMB
12temozolomide45 1310.4MSH2, MLH1
13hematoxylin459.4MKI67, KRT10
14etoposide45 51 61 1312.4MLH1, NME1, GZMB
15ribonucleic acid459.4GZMB, NME1, MMP13
16bromodeoxyuridine459.4KRT10, MKI67, MLH1
17o6-methylguanine459.4MLH1, MSH2
18chi 2459.3MLH1, MKI67, NME1
19carboplatin45 51 1311.1MSH2, MLH1
20dexamethasone45 51 30 1312.1MMP13, NME1, GZMB, KRT10
21crcs459.1NME1, MSH2, MLH1
22oligonucleotide459.1KRT17, GZMB, NME1, MMP13
23irinotecan45 51 1311.0MKI67, MLH1
24lactate459.0GZMB, NME1, MKI67
25fatty acid458.9MLH1, MKI67, NME1, KRT10
26progesterone45 30 61 26 1312.9KRT10, NME1, MKI67, MLH1
27thymidylate458.9MSH2, MKI67, MLH1
28nitric oxide45 26 1310.8GZMB, NME1, MMP13, MKI67
29p002458.8NME1, MMP13, MKI67, MLH1
30thymidine45 269.7MLH1, MKI67, MMP13, NME1
31doxorubicin45 51 1310.7MSH2, MKI67, MLH1
32oxygen45 269.6MLH1, MKI67, MMP13, GZMB
33alanine458.6MLH1, MSH2, NME1, GZMB
34steroid458.6KRT10, GZMB, NME1, MKI67, MLH1
35proline458.6KRT10, MSH2, MKI67, MLH1
36biotin45 26 1310.5MLH1, MKI67, MSH2, NME1
375fluorouracil458.5MLH1, MKI67, MSH2, NME1
38vegf458.4MLH1, MKI67, MMP13, NME1, GZMB
39atp45 309.3MLH1, MSH2, NME1, GZMB, KRT17
40arginine458.2KRT10, GZMB, MSH2, MKI67, MLH1
41cisplatin45 51 61 1311.1MLH1, MKI67, MSH2, NME1, GZMB
42estrogen458.1MLH1, MKI67, MMP13, NME1, GZMB, KRT10
43calcium45 51 26 1311.0MLH1, MKI67, MMP13, NME1, GZMB, KRT10
44retinoic acid45 268.7MLH1, MKI67, MMP13, NME1, GZMB, KRT17
45tyrosine457.7MLH1, MKI67, MMP13, NME1, GZMB, KRT17
46serine457.4MKI67, MMP13, MSH2, NME1, GZMB, KRT17
47paraffin456.8KRT10, MLH1, MKI67, MMP13, MSH2, NME1

GO Terms for genes affiliated with Keratoacanthoma

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Cellular components related to Keratoacanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.7KRT10, KRT17

Biological processes related to Keratoacanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:00062989.1MSH2, MLH1
2somatic hypermutation of immunoglobulin genesGO:00164469.0MSH2, MLH1
3isotype switchingGO:00451908.8MSH2, MLH1

Molecular functions related to Keratoacanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1guanine/thymine mispair bindingGO:00321378.8MSH2, MLH1
2single-stranded DNA bindingGO:00036978.6NME1, MSH2, MLH1
3ATP bindingGO:00055248.1NME1, MSH2, MKI67, MLH1

Products for genes affiliated with Keratoacanthoma

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Sources for Keratoacanthoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet