MCID: KRT005
MIFTS: 49

Keratoacanthoma

Categories: Rare diseases, Skin diseases, Eye diseases, Genetic diseases, Cancer diseases

Aliases & Classifications for Keratoacanthoma

MalaCards integrated aliases for Keratoacanthoma:

Name: Keratoacanthoma 12 72 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3149
MeSH 41 D007636
NCIt 46 C3146
UMLS 69 C0022572

Summaries for Keratoacanthoma

MalaCards based summary : Keratoacanthoma is related to cervical squamous cell carcinoma and keratosis, and has symptoms including pruritus and exanthema. An important gene associated with Keratoacanthoma is MSH2 (MutS Homolog 2), and among its related pathways/superpathways are Pathways in cancer and DNA Damage. The drugs Dabrafenib and Trametinib have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and lung, and related phenotypes are digestive/alimentary and integument

Wikipedia : 72 Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) skin tumour that is... more...

Related Diseases for Keratoacanthoma

Diseases in the Keratoacanthoma family:

Familial Keratoacanthoma

Diseases related to Keratoacanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 cervical squamous cell carcinoma 30.0 KRT17 MKI67 TP53
2 keratosis 29.4 FLG KRT10 KRT17 TP53
3 bowen's disease 29.4 KRT10 KRT16 KRT17 MKI67
4 steatocystoma multiplex 29.3 KRT10 KRT16 KRT17
5 nodular malignant melanoma 29.2 CDKN1A DSG1
6 adenocarcinoma 29.2 CDKN1A MLH1 MSH2 TP53
7 papilloma 29.1 CDKN1A FLG KRT10 TP53
8 discoid lupus erythematosus 29.0 FLG GZMB KRT10 KRT16
9 basal cell carcinoma 28.9 CDKN1A KRT10 KRT16 KRT17 MKI67 TP53
10 lichen planus 28.7 FLG GZMB KRT10 KRT16 TP53
11 psoriasis 28.6 FLG KRT10 KRT16 KRT17
12 generalized eruptive keratoacanthoma 12.1
13 familial keratoacanthoma 12.1
14 muir-torre syndrome 11.9
15 vulvar keratoacanthoma-like carcinoma 11.9
16 multiple self-healing squamous epithelioma 11.7
17 palmoplantar carcinoma, multiple self-healing 11.1
18 squamous cell carcinoma 10.7
19 brain ependymoma 10.5 MKI67 TP53
20 spitz nevus 10.5 MKI67 TP53
21 squamous cell carcinoma of the larynx 10.5 MKI67 TP53
22 oral leukoplakia 10.4 MKI67 TP53
23 eccrine sweat gland neoplasm 10.4 KRT17 TP53
24 vulvar intraepithelial neoplasia 10.4 KRT10 TP53
25 lichen sclerosus 10.4 GZMB TP53
26 adenosarcoma 10.4 MKI67 TP53
27 cervix uteri carcinoma in situ 10.4 KRT17 TP53
28 soft tissue sarcoma 10.4 MKI67 TP53
29 basal cell carcinoma, infundibulocystic 10.4 KRT10 KRT17
30 large cell acanthoma 10.4 KRT10 KRT17
31 embryonal sarcoma 10.3 MKI67 TP53
32 appendix carcinoid tumor 10.3 MLH1 MSH2
33 adenosquamous colon carcinoma 10.3 MLH1 MSH2
34 invasive bladder transitional cell carcinoma 10.3 CDKN1A TP53
35 bladder transitional cell papilloma 10.3 CDKN1A TP53
36 necrotizing sialometaplasia 10.3 GZMB MKI67 TP53
37 sebaceous adenoma 10.3 MLH1 MSH2
38 lower lip cancer 10.3 MLH1 MSH2
39 basaloid squamous cell carcinoma 10.3 KRT17 TP53
40 atypical follicular adenoma 10.3 CDKN1A TP53
41 anal fistula 10.3 MLH1 MSH2
42 anal squamous cell carcinoma 10.3 MLH1 TP53
43 cerebral primitive neuroectodermal tumor 10.3 MSH2 TP53
44 atypical polypoid adenomyoma 10.3 MLH1 MSH2
45 striate palmoplantar keratoderma 10.3 DSG1 KRT10
46 lynch syndrome i 10.3 MLH1 MSH2
47 inverted papilloma 10.3 MKI67 TP53
48 suppressor of tumorigenicity 3 10.2 CDKN1A TP53
49 hidradenocarcinoma 10.2 MKI67 TP53
50 pachyonychia congenita 2 10.2 KRT16 KRT17

Graphical network of the top 20 diseases related to Keratoacanthoma:



Diseases related to Keratoacanthoma

Symptoms & Phenotypes for Keratoacanthoma

UMLS symptoms related to Keratoacanthoma:


pruritus, exanthema

MGI Mouse Phenotypes related to Keratoacanthoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 CDKN1A KRT16 KRT17 MLH1 MSH2 TP53
2 integument MP:0010771 9.17 CDKN1A DSG1 KRT16 KRT17 MLH1 MSH2

Drugs & Therapeutics for Keratoacanthoma

Drugs for Keratoacanthoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dabrafenib Approved, Investigational Phase 2 44462760 44516822
2
Trametinib Approved Phase 2 871700-17-3 11707110
3
nivolumab Approved Phase 2 946414-94-4
4 Protein Kinase Inhibitors Phase 2
5 Antibodies Phase 2
6 Antibodies, Monoclonal Phase 2
7 Immunoglobulins Phase 2
8
Sorafenib Approved, Investigational 284461-73-0 216239 406563
9
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
10
Niacin Approved, Investigational, Nutraceutical 59-67-6 938
11
Nicotinamide Approved, Investigational, Nutraceutical 98-92-0 936
12 Micronutrients
13 Nicotinic Acids
14 Trace Elements
15 Vitamin B Complex
16 Vitamins
17 Folate Nutraceutical
18 Vitamin B3 Nutraceutical
19 Vitamin B9 Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Biomarker Study Comparing the Combination of BRAF Inhibitor Dabrafenib With MEK Inhibitor Trametinib Versus the Combination After Monotherapy With Dabrafenib or Trametinib Completed NCT02314143 Phase 2 Dabrafenib;Trametinib
2 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2
3 A Pilot Study of Trientine With Vemurafenib for the Treatment BRAF Mutated Metastatic Melanoma Withdrawn NCT02068079 Phase 1 Vemurafenib and Trientine
4 Tolerance of Targeted Therapy Used in Metastatic Melanoma in Patients Aged Over 65 and 75-year-old Recruiting NCT03155217
5 Prospective, Non-interventional, Post-authorization Safety Study That Includes All Patients Diagnosed as Unresectable Differentiated Thyroid Carcinoma and Treated With Sorafenib Recruiting NCT02185560 Sorafenib (Nexavar, BAY43-9006)

Search NIH Clinical Center for Keratoacanthoma

Cochrane evidence based reviews: keratoacanthoma

Genetic Tests for Keratoacanthoma

Anatomical Context for Keratoacanthoma

MalaCards organs/tissues related to Keratoacanthoma:

38
Skin, Thyroid, Lung, Colon, Bone, Myeloid, T Cells

Publications for Keratoacanthoma

Articles related to Keratoacanthoma:

(show top 50) (show all 634)
# Title Authors Year
1
Successful Treatment of a Keratoacanthoma with Electrochemotherapy: A Case Report. ( 29368221 )
2018
2
Cutaneous intravascular CD30+ T-cell pseudolymphoma occurring in a regressing keratoacanthoma. ( 29369392 )
2018
3
Generalized eruptive keratoacanthoma with vitiligo followed by the development of prurigo nodularis: A case report and published work review. ( 29058335 )
2018
4
Expression of PD-L1 in keratoacanthoma and different stages of progression in cutaneous squamous cell carcinoma. ( 28501937 )
2017
5
Fine and Benign, Until It Becomes Malignant: The Enigmatic Keratoacanthoma. ( 28705282 )
2017
6
Reduced expression of the ATP2A2 gene in vemurafenib-induced keratoacanthoma-like papules in a melanoma patient. ( 27805257 )
2017
7
Keratoacanthoma-like dermatofibroma: A dermoscopic challenge. ( 28087033 )
2017
8
Eruptive Keratoacanthoma-Like Discoid Lupus Erythematosus. ( 28816744 )
2017
9
Keratoacanthoma-Like Growths of Incontinentia Pigmenti Successfully Treated with Intralesional Methotrexate. ( 28414858 )
2017
10
Keratoacanthoma of the Nasal Septum Secondary to Ranibizumab Use. ( 28584672 )
2017
11
A Case of Exophytic Pilomatricoma Clinically Resembling Keratoacanthoma. ( 28392667 )
2017
12
Multiple keratoacanthoma centrifugum marginatum in a young boy, and review of the literature. ( 28543888 )
2017
13
Complete regression of keratoacanthoma with topical tazarotene gel 0.1%: therapeutic and pathophysiological perspectives. ( 28895378 )
2017
14
Keratoacanthoma Centrifugum Marginatum: Response to Acitretin. ( 28270315 )
2017
15
Keratoacanthoma, palmoplantar keratoderma developing in an advanced melanoma patient treated with vemurafenib regressed by blockade of mitogen-activated protein kinase kinase signaling. ( 28439948 )
2017
16
Advances in histopathological diagnosis of keratoacanthoma. ( 28256761 )
2017
17
Use of topical ephedrine and naphazoline in the treatment of a keratoacanthoma: two case reports. ( 28712267 )
2017
18
Multiple keratoacanthoma centrifugum marginatum associated with juvenile idiopathic arthritis and persistent corneal epithelial defect: an unusual case. ( 28906090 )
2017
19
Calcified Keratoacanthoma with Tumoral Calcinosis in a 10-year-old Boy: A mere Co-incidence? ( 29263542 )
2017
20
Keratoacanthoma centrifugum marginatum: an unusual clinical and histopathological diagnostic pitfall. ( 28730244 )
2017
21
Use of photodynamic therapy and acitretin in generalized eruptive keratoacanthoma of Grzybowski. ( 28948204 )
2017
22
Keratoacanthoma of the lip: A case report with emphasis on histogenesis. ( 28479697 )
2017
23
Keratoacanthoma en plaque/nodule: A brief report of the clinicopathological features of five cases. ( 28332728 )
2017
24
Complete regression of crateriform verruca after partial biopsy: Another type of epithelial crateriform tumor or a subtype of keratoacanthoma? ( 29235666 )
2017
25
Keratoacanthoma management: results of a survey of UK dermatologists and surgeons. ( 28758190 )
2017
26
Cytokeratin 17 and Ki-67: Immunohistochemical markers for the differential diagnosis of keratoacanthoma and squamous cell carcinoma. ( 28454431 )
2017
27
Relationship between Human Papilloma Virus and Subungual Keratoacanthoma: Two Case Reports and the Outcomes of Surgical Treatment. ( 28232913 )
2017
28
Subungual Keratoacanthoma in a Patient With Yellow Nail Syndrome. ( 27158885 )
2016
29
Clinicopathological study of crateriform verruca: Crateriform epithelial lesions histopathologically distinct from keratoacanthoma. ( 26970425 )
2016
30
Insulin-like growth factor 2 mRNA-binding protein-3 as a marker for distinguishing between cutaneous squamous cell carcinoma and keratoacanthoma. ( 26782292 )
2016
31
Keratoacanthoma-appearing melanoma metastases in a patient receiving pembrolizumab therapy. ( 27408934 )
2016
32
Subungual keratoacanthoma in a pianist. ( 27348330 )
2016
33
Keratoacanthoma centrifugum marginatum: A diagnostic and therapeutic challenge. ( 27274538 )
2016
34
Keratoacanthoma (KA): An update and review. ( 26853179 )
2016
35
The distinction of keratoacanthoma from various types of squamous cell carcinoma with crateriform architecture. ( 27670127 )
2016
36
Distal Digital Keratoacanthoma in Patients With Incontinentia Pigmenti. ( 26614487 )
2016
37
Acute development of keratoacanthoma at a full-thickness skin graft donor site shortly after surgery. ( 27027399 )
2016
38
Histopathological diagnosis of epithelial crateriform tumors: Keratoacanthoma and other epithelial crateriform tumors. ( 27076258 )
2016
39
Aberrant DNA Methylation in Keratoacanthoma. ( 27788211 )
2016
40
Keratoacanthoma Arising Over Margin of Porokeratosis of Mibelli: A New Association? ( 26955114 )
2016
41
Clues in DeRmoscopy: Dermoscopy of keratoacanthoma. ( 27528474 )
2016
42
Keratoacanthoma formation after skin grafting: A brief report and pathophysiological hypothesis. ( 27273800 )
2016
43
Cutaneous Epithelial Lesions Induced by N-Methyl-N-nitrosourea in Male Sprague-Dawley Rats: A Possible Animal Model for Human Keratoacanthoma. ( 26722034 )
2016
44
Keratoacanthoma of the conjunctiva in a young patient. ( 27463634 )
2016
45
Human polyomavirus DNA detection in keratoacanthoma and Spitz naevus: no evidence for a causal role. ( 27993945 )
2016
46
Unusual Ultrasound Appearance of Subungual Keratoacanthoma With Clinical and Histological Correlation. ( 26833061 )
2016
47
Keratoacanthoma Shares Driver Mutations with Cutaneous Squamous Cell Carcinoma. ( 27283355 )
2016
48
"Nevoid Eruptive Keratoacanthoma" - Yet Another Atypical Manifestation of Generalized Keratoacanthoma. ( 26955113 )
2016
49
Giant keratoacanthoma of the lower lip: case report and review of the published literature. ( 26742162 )
2016
50
Systemic methotrexate for prurigo nodularis and keratoacanthomas in actinically damaged skin. ( 27486591 )
2016

Variations for Keratoacanthoma

Expression for Keratoacanthoma

Search GEO for disease gene expression data for Keratoacanthoma.

Pathways for Keratoacanthoma

GO Terms for Keratoacanthoma

Cellular components related to Keratoacanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.91 CDKN1A DSG1 FLG GZMB KRT10 KRT16
2 cornified envelope GO:0001533 9.33 DSG1 FLG KRT10
3 condensed chromosome GO:0000793 9.32 MKI67 MLH1
4 mismatch repair complex GO:0032300 8.96 MLH1 MSH2
5 intermediate filament GO:0005882 8.92 FLG KRT10 KRT16 KRT17

Biological processes related to Keratoacanthoma according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.89 CDKN1A MLH1 MSH2 TP53
2 cell cycle arrest GO:0007050 9.75 CDKN1A MSH2 TP53
3 cellular response to ionizing radiation GO:0071479 9.63 CDKN1A TP53
4 keratinocyte differentiation GO:0030216 9.63 FLG KRT10 KRT16
5 mismatch repair GO:0006298 9.62 MLH1 MSH2
6 intrinsic apoptotic signaling pathway GO:0097193 9.62 CDKN1A TP53
7 keratinization GO:0031424 9.62 DSG1 KRT10 KRT16 KRT17
8 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.61 GZMB TP53
9 positive regulation of reactive oxygen species metabolic process GO:2000379 9.61 CDKN1A TP53
10 cellular response to gamma radiation GO:0071480 9.6 CDKN1A TP53
11 establishment of skin barrier GO:0061436 9.58 FLG KRT16
12 response to hyperoxia GO:0055093 9.57 CDKN1A TP53
13 somatic hypermutation of immunoglobulin genes GO:0016446 9.56 MLH1 MSH2
14 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.55 CDKN1A TP53
15 isotype switching GO:0045190 9.54 MLH1 MSH2
16 determination of adult lifespan GO:0008340 9.52 MSH2 TP53
17 replicative senescence GO:0090399 9.51 CDKN1A TP53
18 response to UV-B GO:0010224 9.49 MSH2 TP53
19 positive regulation of isotype switching to IgG isotypes GO:0048304 9.48 MLH1 MSH2
20 positive regulation of isotype switching to IgA isotypes GO:0048298 9.43 MLH1 MSH2
21 somatic recombination of immunoglobulin gene segments GO:0016447 9.4 MLH1 MSH2
22 signal transduction by p53 class mediator GO:0072331 9.37 CDKN1A TP53
23 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.33 CDKN1A MSH2 TP53
24 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.26 MLH1 MSH2
25 response to X-ray GO:0010165 9.13 CDKN1A MSH2 TP53
26 cornification GO:0070268 9.02 DSG1 FLG KRT10 KRT16 KRT17

Molecular functions related to Keratoacanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein C-terminus binding GO:0008022 9.5 MKI67 MSH2 TP53
2 structural constituent of epidermis GO:0030280 9.26 FLG KRT10
3 structural molecule activity GO:0005198 9.26 FLG KRT10 KRT16 KRT17
4 mismatched DNA binding GO:0030983 9.16 MLH1 MSH2
5 guanine/thymine mispair binding GO:0032137 8.62 MLH1 MSH2

Sources for Keratoacanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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