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MCID: KRT005

Keratoacanthoma malady
45 genes, 2 tissues, 500 related diseases, 24 phenotypes, 41 articles, clinical trials.

Summaries for Keratoacanthoma

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44Wikipedia, 22MalaCards
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Wikipedia: Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) skin tumour that is...44 more...

MalaCards: Keratoacanthoma, also known as keratoacanthoma (morphologic abnormality), is related to squamous cell carcinoma and muir-torre syndrome. An important gene associated with Keratoacanthoma is KRT10 (keratin 10), and among its related pathways are Signal transduction_PTEN pathway and DNA damage ATM/ATR regulation of G1/S checkpoint. The compounds egcg and roscovitine have been mentioned in the context of this disorder. Affiliated tissues include skin and b cells, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Aliases & Descriptions for Keratoacanthoma

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6Disease Ontology, 8DISEASES, 32Novoseek , 43UMLS, 40SNOMED-CT, 24MeSH, 27NCIt
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Aliases & Descriptions:

keratoacanthoma 6 8 32 43
keratoacanthoma (morphologic abnormality) 6
keratoacanthoma (disorder) 6

Related Diseases for Keratoacanthoma

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13GeneCards, 14GeneDecks
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Diseases related to keratoacanthoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 497)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma33.2RBP1, CD44, MMP10, MMP19, MMP7, MKI67
2muir-torre syndrome31.7MSH2, MSH6, MLH1
3actinic keratosis25.1PCNA, BCL2, MMP1, MKI67, CCNA2, TP53
4anaplastic large cell lymphoma24.4PCNA, BCL2, BCL2L1, MUC1, CDKN1A, CD44
5basal cell carcinoma23.8BCL2, BAK1, JUP, CD44, IVL, MMP1
6keratosis23.2PCNA, BCL2, JUP, CDKN1A, IVL, MMP1
7carcinoma20.9PCNA, RBP1, BCL2, BCL2L1, MUC1, UCHL1
8steatocystoma multiplex13.7KRT16, KRT17, KRT10
9predominantly cortical thymoma13.7IVL, KRT14
10acanthoma13.7PCNA, IVL, KRT16, KRT10
11monilethrix13.6IVL, KRT16, KRT17
12sebaceous gland neoplasm13.6MSH6, MLH1
13pachyonychia congenita13.6KRT16, KRT17
14small intestine carcinoma13.6MSH2, MSH6, MLH1
15epidermolytic acanthoma13.6KRT16, KRT10
16nonepidermolytic palmoplantar keratoderma13.6KRT16, KRT10, DSG1
17turcot syndrome13.6MSH2, MSH6, MLH1
18cafe-au-lait spots13.6MSH2, MSH6, MLH1
19epidermolytic hyperkeratosis13.5IVL, FLG, KRT16, KRT10
20ichthyosis vulgaris13.5IVL, FLG, KRT14
21hidradenitis suppurativa13.5KRT10, KRT14, DSG2
22epidermolytic palmoplantar keratoderma13.5JUP, KRT16, KRT14
23hailey-hailey disease13.5JUP, IVL, DSG1, DSG3
24impetigo13.5DSG1, DSG2, DSG3
25thyroid medullary carcinoma13.5MSH2, MLH1, MKI67, GZMB, KRT14
26retinal ischemia13.5PCNA, BCL2L1, BAK1
27contact dermatitis13.4IVL, GZMB, FLG, KRT16, KRT17
28palmoplantar keratosis13.4JUP, KRT16, KRT17, KRT10, DSG1
29benign mammary dysplasia13.4BCL2, BAK1
30clear cell meningioma13.4MUC1, MKI67
31anaplastic plasmacytoma13.4PCNA, MKI67, TP63
32vernal keratoconjunctivitis13.4MMP1, MMP10, MMP13, MKI67
33bullous pemphigoid13.4IVL, FLG, KRT14, DSG1, DSG3
34sarcomatoid renal cell carcinoma13.3PCNA, MUC1, JUP
35pemphigus vulgaris13.3JUP, IVL, DSG1, DSG2, DSG3
36epithelial-myoepithelial carcinoma13.3PCNA, TP63, KRT14
37hidradenitis13.3MUC1, KRT10, KRT14, DSG2
38neurofibromatosis13.3MSH2, MSH6, MMP13, MLH1, KRT14
39epidermolysis bullosa simplex13.3IVL, FLG, KRT16, KRT17, KRT10, KRT14
40breast malignant phyllodes tumor13.3MKI67, CCNA2, TP63
41refractive error13.3MMP1, MMP10, MMP13, MMP7
42primary cutaneous amyloidosis13.3BCL2, KRT17, KRT10, OSM
43papillary adenocarcinoma13.3MUC1, SLC2A1, NME1
44bronchiolitis obliterans13.2MUC1, MMP7, GZMB, DSG3
45neuroma13.2PCNA, MSH2, MKI67, SLC2A1
46cervical cancer13.2TP63, KRT14
47keratoconjunctivitis13.2MMP1, MMP10, MMP13, MKI67
48ameloblastic carcinoma13.2MUC1, MKI67, TP63
49porokeratosis13.2IVL, FLG, TP53
50middle ear cholesteatoma13.2PCNA, IVL, MMP1, TGFA

Graphical network of the top 20 diseases related to keratoacanthoma:



Graphical network of diseases related to keratoacanthoma

Clinical Features for Keratoacanthoma

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Drugs & Therapeutics for Keratoacanthoma

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Genetic Tests for Keratoacanthoma

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Anatomical Context for Keratoacanthoma

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22MalaCards
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MalaCards organs/tissues related to keratoacanthoma:

22
Skin, B cells

Phenotypes for genes affiliated with Keratoacanthoma

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25MGI
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MGI Mouse Phenotypes related to keratoacanthoma:

25 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1endocrine/exocrine gland phenotypeMP:000537910.5TP63
2respiratory system phenotypeMP:000538810.3TP63
3craniofacial phenotypeMP:000538210.2KRT10, KRT16, FLG
4liver/biliary system phenotypeMP:00053709.4TP53, IKBKG, RBP1
5limbs/digits/tail phenotypeMP:00053718.9KRT10, CRABP2, CRABP1, CTNNB1, TP63, MMP13
6behavior/neurological phenotypeMP:00053868.9KRT16, CTNNB1, IKBKG, CD44, CDKN1A, UCHL1
7reproductive system phenotypeMP:00053898.4NME1, KRT14, PTGS2, TP63, CASP3, IKBKG
8hearing/vestibular/ear phenotypeMP:00053778.1KRT10, CRABP2, CRABP1, CTNNB1, CASP3, FLG
9renal/urinary system phenotypeMP:00053678.0AGTR1, CTNNB1, TP63, CASP3, CDKN1A, BAK1
10hematopoietic system phenotypeMP:00053978.0CD3D, GZMB, FLG, CCNA2, IKBKG, DSG3
11adipose tissue phenotypeMP:00053757.7TGFA, DSG3, PTGS2, TP53, IKBKG, MMP19
12immune system phenotypeMP:00053877.7TP53, TP63, KRT10, KRT14, AGTR1, DSG3
13pigmentation phenotypeMP:00011867.6KRT14, KRT17, CTNNB1, TP53, CASP3, IKBKG
14mortality/agingMP:00107687.0UCHL1, KRT14, KRT10, KRT17, KRT16, CRABP2
15skeleton phenotypeMP:00053906.7TGFA, CTNNB1, PTGS2, TP63, TP53, CASP3
16vision/eye phenotypeMP:00053915.6RBP1, TGFA, DSG3, KRT14, CTNNB1, PTGS2
17tumorigenesisMP:00020065.4NME1, BCL2L1, BCL2, MUC1, MSH2, KRT14
18cardiovascular system phenotypeMP:00053855.4CASP3, TP53, TP63, PTGS2, CTNNB1, AGTR1
19nervous system phenotypeMP:00036315.3CASP3, TP53, PTGS2, CTNNB1, OSM, SLC2A1
20digestive/alimentary phenotypeMP:00053815.0TP53, TP63, PTGS2, CTNNB1, KRT16, KRT17
21integument phenotypeMP:00107714.3NME1, OSM, TGFA, DSG3, KRT14, KRT10
22cellular phenotypeMP:00053844.1FLG, CCNA2, IKBKG, CASP3, TP53, TP63
23growth/size phenotypeMP:00053784.0TP53, TP63, PTGS2, CTNNB1, KRT16, KRT10
24homeostasis/metabolism phenotypeMP:00053763.5TP63, TP53, CASP3, IKBKG, FLG, PTGS2

Publications for genes affiliated with Keratoacanthoma

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35PubMed
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Articles related to keratoacanthoma:

(show all 41)
idTitleAuthorsYearAffiliating Genes
1Glut-1 expression and in situ CD1a/CD57 immunologic d eficit in keratoacanthoma and squamous cell carcinoma of immunocompetent patien ts. (21475039)Cabibi D.... Aragona F.2011SLC2A1
2Low rates of somatic p53 mutations in keratoacanthomas. (18829268)Suk J.D.... Kim D.K.2009TP53
3The Bcl-xL inhibitor of apoptosis is preferentially expressed in cutaneous squamous cell carcinoma compared with that in keratoacanthoma. (19165861)VasiljeviA8 N.... Forslund O.2009BCL2L1
4The expression of p63 and p53 in keratoacanthoma and intraepidermal and invasive neoplasms of the skin. (19577853)Sakiz D.... Kabukcuoglu F.2009TP53, TP63
5PGP 9.5 expression in cutaneous keratoacanthomas and squamous cell carcinomas. (19488775)Mastoraki A.... Aroni K.2009UCHL1
6Solitary subungual keratoacanthoma arising in an MSH2 germline mutation carrier: confirmation of a relationship by immunohistochemic al analysis. (19602866)Stoebner P.E.... Meunier L.2009MSH2
7Expression of apoptotic and cell proliferation regulatory proteins in keratoacanthomas and squamous cell carcinomas of the skin. (18079070)Ribeiro D.... Marques M.E.2008BCL2, CASP3, PCNA
8Keratoacanthoma with perineural invasion: an indicator for aggressive behavior? (18445070)Basoglu Y.... StAonder S.2008DSG1
9Keratin and filaggrin expression in keratoacanthoma. (18005116)Ito Y.... Mizutani H.2008KRT14, KRT17, KRT16
10Beta-catenin and CD44 expression in keratoacanthoma and squamous cell carcinoma of the skin. (17679465)Tataroglu C.... Apa D.D.2007CTNNB1, CD44
11Possible key role of granzyme B in keratoacanthoma regression. (16497444)Batinac T.... Hadzisejdic I.2006GZMB
12Transformation-specific matrix metalloproteinases, MMP-7 and MMP-13, are present in epithelial cells of keratoacanthomas. (16699496)Kuivanen T.T.... Saarialho-Kere U.K.2006MMP7, MMP13, MMP10
13Expression of cell cycle and apoptosis regulatory proteins in keratoacanthoma and squamous cell carcinoma. (16781827)Batinac T.... Zauhar G.2006BCL2, BAK1
14A comparative study of granzyme B expression in keratoacanthoma and squamous cell carcinoma. (16952444)Batinac T.... Zauhar G.2006GZMB
15Value of MLH1 and MSH2 mutations in the appearance of Muir-Torre syndrome phenotype in HNPCC patients presenting sebaceous gland tumors or keratoacanthomas. (16826164)Ponti G.... Seidenari S.2006MSH2, MLH1, MSH6
16Primary cutaneous CD30 anaplastic large cell lymphoma with keratoacanthoma-like pseudocarcinomatous hyperplasia and marked eosinophilia and neutrophilia. (15186435)Lin J.H.... Lee J.Y.2004MUC1
17Biological behavior of keratoacanthoma and squamous cell carcinoma: telomerase activity and COX-2 as potential markers. (14976535)Putti T.C.... Lee Y.S.2004TP53, PTGS2
18Mechanism of transepithelial elimination of elastic fibers in keratoacanthoma. (15260849)Ohashi A.... Fukuda Y.2004MMP1
19Expression of keratin and involucrin in keratoacanthoma: an immunohistochemical aid to diagnosis. (15033195)Ichikawa E.... Watanabe S.2004IVL
20Cytokeratin 10 and Ki-67 nuclear marker expression in keratoacanthoma and squamous cell carcinoma. (15588557)Basta-Juzbasic A.... Loncaric D.2004MKI67, KRT10
21Amphiregulin overexpression results in rapidly growing keratinocytic tumors: an in vivo xenograft model of keratoacanthoma. (14633617)Billings S.D.... Travers J.B.2003AREG
22Differences between squamous cell carcinoma and keratoacanthoma in angiotensin type-1 receptor expression. (11337361)Takeda H.... Kondo S.2001AGTR1
23The potential role of abnormal E-cadherin and alpha-, beta- and gamma-catenin immunoreactivity in the determination of the biological behaviour of keratoacanthoma. (11703284)Papadavid E.... Chu A.C.2001JUP
24Comparison of oncostatin M expression in keratoacanthoma and squamous cell carcinoma. (10786810)Tran T.A.... Carlson J.A.2000OSM
25Keratoacanthomas have an immunosuppressive cytokine environment of increased IL-10 and decreased GM-CSF compared to squamous cell carcinomas. (10408389)Lowes M.A.... Halliday G.M.1999CD3D
26Comparison of mitotic cyclins and cyclin-dependent kinase expression in keratoacanthoma and squamous cell carcinoma. (10551411)Tran T.A.... Carlson J.A.1999CCNA2
27Immunohistochemical staining for desmogleins 1 and 2 in keratinocytic neoplasms with squamous phenotype: actinic keratosis, keratoacanthoma and squamous cell carcinoma of the skin. (9579833)Krunic A.L.... Clark R.E.1998DSG2
28Desmoglein in multiple self-healing squamous epithelioma of Ferguson-Smith--comparison of staining patterns with actinic keratoacanthoma and squamous cell carcinoma of the skin. (9705163)Krunic A.L.... Clark R.E.1998DSG1, DSG3
29Stereological estimation of mean nuclear volume and staining pattern of Ki-67 antigen in keratoacanthomas and squamous cell carcinomas. (9653912)SaA9ol O.... PabuAsAsuoA9lu U.1998MKI67
30Keratoacanthoma and squamous cell carcinoma: study of PCNA and Le(Y) expression. (9274958)Tsuji T.1997PCNA
31Increased concentrations of 3,4-didehydroretinol and retinoic acid-binding protein (CRABPII) in human squamous cell carcinoma and keratoacanthoma but not in basal cell carcinoma of the skin. (8618041)Vahlquist A.... Torma H.1996CRABP1, CRABP2, RBP1
32Proliferating cell nuclear antigen (PCNA) expression in pseudoepitheliomatous hyperplasia, keratoacanthoma and squamous cell carcinoma of the skin. (8893923)Li J.... Lee Y.S.1996PCNA
33Differential expression of desmosomal glycoproteins in keratoacanthoma and squamous cell carcinoma of the skin: an immunohistochemical aid to diagnosis. (8891017)Krunic A.L.... Cvijetic O.B.1996DSG3
34Keratoacanthoma versus squamous cell carcinoma. An immunohistochemical reappraisal of p53 protein and proliferating cell nuclear antigen expression in keratoacanthoma-like tumors. (8600793)Cain C.T.... Argenyi Z.B.1995PCNA
35Patterns of cell proliferation in actinic keratoacanthomas and squamous cell carcinomas of the skin. Immunohistochemical study using the MIB 1 antibody in formalin-fixed paraffin sections. (8600794)SkA!lovA! A.... Michal M.1995MKI67
36Proliferating cell nuclear antigen immunostaining in keratoacanthoma and squamous cell carcinoma of the skin. (7617390)Royds J.A.... Bleehen S.S.1994PCNA
37p53 expression in pseudoepitheliomatous hyperplasia, keratoacanthoma, and squamous cell carcinoma of skin. (8168036)Lee Y.S.... Teh M.1994TP53
38Keratoacanthoma: a deficient squamous cell carcinoma? Study of bcl-2 expression. (7699118)Sleater J.P.... Hendricks J.B.1994BCL2
39'Anti-metastatic' nm23 gene product expression in keratoacanthoma and squamous cell carcinoma. (8358113)Stephenson T.J.... Rees R.C.1993NME1
40Proliferating cell nuclear antigen distribution in keratoacanthoma and squamous cell carcinoma. (7507945)Phillips P.... Helm K.F.1993PCNA
41Transforming growth factor alpha expression helps to distinguish keratoacanthomas from squamous cell carcinomas. (1863074)Ho T.... Finzi E.1991TGFA

Expression for genes affiliated with Keratoacanthoma

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Keratoacanthoma

Pathways for genes affiliated with Keratoacanthoma

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41Thomson Reuters, 10EMD Millipore, 20KEGG, 36QIAGEN, 38Reactome, 3Cell Signaling Technology, 37R&D Systems, 34PharmGKB
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Pathways related to keratoacanthoma according to GeneDecks:

(show top 50)    (show all 54)
idPathwayScoreTop Affiliating Genes
1Signal transduction_PTEN pathway4110.8PCNA
2DNA damage ATM/ATR regulation of G1/S checkpoint1010.6CCNA2
3Colorectal cancer2010.6MSH6, MSH2
4Pancreatic cancer2010.4IKBKG
5Mismatch Repair in Eukaryotes3610.3MLH1, MSH6, MSH2, PCNA
6Apoptosis3810.3DSG3, DSG2, DSG1, GZMB, BAK1
7Mismatch repair2010.3MLH1, MSH6, MSH2, PCNA
8Adhesion310.2JUP, CD44
9Signal transduction PTEN pathway1010.1PCNA, CDKN1A, CASP3
10Activation of Matrix Metalloproteinases3810.1MMP7, MMP13, MMP10, MMP1
11Inhibition of Matrix Metalloproteinases3610.0MMP7, MMP19, MMP13, MMP10, MMP1
12Metalloproteases in connective tissue degradation1010.0MMP7, MMP19, MMP13, MMP10, MMP1
13Transcription P53 signaling pathway109.9TP53
14IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types379.9BCL2, CD3D, GZMB
15Development_Thrombopoetin signaling via JAK-STAT pathway419.8OSM, CDKN1A, BCL2L1
16Cell adhesion_ECM remodeling419.8MMP7, MMP13, MMP10, MMP1, CD44
17Cell adhesion ECM remodeling109.8MMP7, MMP13, MMP10, MMP1, CD44
18Development Thrombopoetin signaling via JAK-STAT pathway109.7OSM, CDKN1A, BCL2L1
19Doxorubicin Pathway (Cancer Cell), Pharmacodynamics349.7TP53, MLH1, MSH2
20Busulfan Pathway, Pharmacodynamics349.6MLH1, MSH2, BCL2L1, BCL2
21GADD45 Pathway369.6TP53, CCNA2, CDKN1A, PCNA
22DNA damage_ATM/ATR regulation of G1/S checkpoint419.5TP53, CCNA2, CDKN1A, PCNA
23DNA damage_Role of Brca1 and Brca2 in DNA repair419.5TP53, MLH1, MSH6, MSH2, PCNA
24DNA damage Role of Brca1 and Brca2 in DNA repair109.5TP53, MLH1, MSH6, MSH2, PCNA
25Signal transduction_AKT signaling419.3TP53, CDKN1A, BCL2L1, PCNA
26UPA-UPAR Pathway369.3MMP7, MMP19, MMP13, MMP10, MMP1
27Celecoxib Pathway, Pharmacodynamics349.1CTNNB1, PTGS2, CASP3, CDKN1A
28Apoptosis and survival_APRIL and BAFF signaling419.1PTGS2, IKBKG, BCL2L1, BCL2
29Apoptosis and survival APRIL and BAFF signaling109.1PTGS2, IKBKG, BCL2L1, BCL2
30DNA Damage39.1MSH2, MSH6, TP53, TP63
31Chronic myeloid leukemia209.1TP53, IKBKG, CDKN1A, BCL2L1
32Selected targets of p53108.9SLC2A1, TP53, CDKN1A, BCL2
33Cell Cycle / Checkpoint Control38.9TP63, TP53, CCNA2, MLH1, CDKN1A, MSH6
34Transcription_P53 signaling pathway418.8CTNNB1, TP53, CDKN1A, BCL2
35Apoptosis through Death Receptors368.6BCL2, IKBKG, CASP3, TP53
36Pathogenesis of ALS368.5TP53, CASP3, BCL2L1, BCL2
37Amyotrophic lateral sclerosis (ALS)208.4BCL2, BCL2L1, CASP3, TP53
38Prostate cancer208.4TGFA, CTNNB1, TP53, IKBKG, CDKN1A, BCL2
39Apoptosis Signaling Pathways378.4TP53, CASP3, CDKN1A, BAK1, BCL2L1, BCL2
40Small cell lung cancer208.3PTGS2, TP53, IKBKG, BCL2L1, BCL2
41Apoptosis208.3TP53, CASP3, IKBKG, BCL2L1, BCL2
42Apoptotic Pathways Triggered By HIV1368.3TP53, CASP3, IKBKG, BAK1, BCL2L1, BCL2
43p53 Mediated Apoptosis368.2BCL2, AREG, CASP3, TP53, TGFA
44Mitochondrial Apoptosis368.0TGFA, TP53, CASP3, AREG, BAK1, BCL2L1
45Cellular Apoptosis Pathway367.8TGFA, TP53, CASP3, IKBKG, AREG, BAK1
46p38 Signaling367.8BCL2, CD3D, AREG, CASP3, TP53, TGFA
47Molecular Mechanisms of Cancer367.2TP53, CTNNB1, TGFA, OSM, CASP3, AREG
48Colorectal Cancer Metastasis367.1CTNNB1, PTGS2, TP53, CASP3, MLH1, MMP7
49Pancreatic Adenocarcinoma366.9AREG, CCNA2, TP53, PTGS2, TGFA, MMP7
50Pathways in cancer206.3BCL2, SLC2A1, TGFA, CTNNB1, TP53, CASP3

Compounds for genes affiliated with Keratoacanthoma

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32Novoseek , 42Tocris Bioscience, 9DrugBank, 18HMDB, 34PharmGKB
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Compounds related to keratoacanthoma according to GeneDecks:

(show top 50)    (show all 220)
idCompoundScoreTop Affiliating Genes
1egcg32 10.5IVL, BCL2L1
2roscovitine32 9.5CCNA2, BCL2L1, PCNA, CTNNB1
312-o-tetradecanoylphorbol 13-acetate32 9.0MMP13, CDKN1A, CD44, UCHL1, IVL, MMP10
4hematoxylin32 8.9KRT10, PCNA, MMP1, MUC1, MKI67, TP63
5calcitriol32 42 9 18 9 12.6CD44, KRT16, KRT10, TGFA, SLC2A1, NME1
6retinoid32 8.6MMP13, KRT16, CRABP2, CRABP1, CTNNB1, FLG
7ly29400232 8.6CD44, GZMB, CASP3, SLC2A1, CCNA2, PTGS2
8arginine32 8.5GZMB, AGTR1, FLG, KRT14, KRT10, CD44
9biotin32 9 18 9 11.5NME1, TGFA, MLH1, CTNNB1, MKI67, CD44
10bromodeoxyuridine32 8.3CTNNB1, KRT10, KRT14, TGFA, PCNA, CDKN1A
11progesterone32 42 9 18 9 12.2KRT10, KRT14, NME1, PCNA, RBP1, BCL2
12dutp32 8.0BCL2L1, KRT10, TP53, CASP3, BAK1, PCNA
13crcs32 7.9NME1, MSH6, MUC1, MLH1, TP53, CTNNB1
14thymidylate32 7.9TP53, PCNA, BCL2L1, MSH2, CDKN1A, MLH1
15agarose32 7.8BCL2, OSM, BCL2L1, MLH1, GZMB, CASP3
16estrogen32 7.8MLH1, MKI67, GZMB, AREG, CCNA2, TP63
17noxa32 7.8BCL2, TP63, BAK1, CDKN1A, TP53, CASP3
18celecoxib32 42 34 9 18 9 12.7MMP1, BCL2, MKI67, CCNA2, CTNNB1, CASP3
19steroid32 7.7MKI67, CCNA2, RBP1, KRT10, KRT16, IVL
20sulindac32 9 9 9.6PCNA, CDKN1A, TP53, PTGS2, CTNNB1, BCL2
21matrigel32 7.6BCL2L1, MMP7, TP63, CTNNB1, TGFA, OSM
22adpribose32 7.3CTNNB1, TP53, CASP3, CCNA2, CDKN1A, BCL2L1
23cytarabine32 34 9 9 10.2TP53, CASP3, PCNA, BCL2, BCL2L1, MUC1
24etoposide32 42 9 9 10.1BCL2, PCNA, BCL2L1, BAK1, NME1, TGFA
25thymidine32 18 8.0TP63, CTNNB1, TGFA, OSM, NME1, TP53
26retinoic acid32 42 18 9.0BCL2L1, BAK1, JUP, CDKN1A, CD44, MMP1
27oxygen32 18 8.0MMP7, AGTR1, CASP3, CCNA2, GZMB, MLH1
28gemcitabine32 34 9 9 9.9BCL2L1, PCNA, BCL2, MUC1, CDKN1A, MLH1
29tamoxifen32 34 9 9 9.7TGFA, KRT14, CRABP2, CTNNB1, TP53, CCNA2
30resveratrol32 9 18 9 9.7BAK1, CCNA2, CASP3, TP53, PTGS2, TGFA
31curcumin32 6.7TP53, BCL2, BCL2L1, BAK1, CDKN1A, IVL
32pd 98,05932 6.5BCL2, BCL2L1, CDKN1A, MMP1, IVL, SLC2A1
33arsenite32 18 7.5BCL2, BCL2L1, CDKN1A, MMP1, CCNA2, CASP3
34genistein32 9 18 9 9.4BCL2L1, CDKN1A, MMP1, MMP13, CCNA2, SLC2A1
35oligonucleotide32 6.3PCNA, BCL2, BCL2L1, JUP, CDKN1A, IVL
36paclitaxel32 34 9 9 9.2JUP, BAK1, BCL2L1, BCL2, PCNA, CDKN1A
37sb 20358032 42 7.2BCL2L1, CCNA2, CTNNB1, PTGS2, MMP13, AGTR1
38cysteine32 6.1AGTR1, UCHL1, BAK1, CD44, IVL, MMP1
39calcium32 9 18 9 9.1KRT10, KRT14, AGTR1, DSG1, DSG2, DSG3
405fluorouracil32 6.0BCL2L1, MUC1, BAK1, MSH2, CDKN1A, IVL
41butyrate32 6.0BCL2, SLC2A1, TGFA, BCL2L1, MUC1, BAK1
42dexamethasone32 42 34 9 9 9.8NME1, SLC2A1, OSM, AGTR1, KRT10, CTNNB1
43actinomycin d32 5.8BCL2, BCL2L1, MUC1, BAK1, CDKN1A, CD44
44doxorubicin32 34 9 9 8.7CD44, TP53, TP63, CTNNB1, TGFA, CASP3
45tyrosine32 5.0CDKN1A, CD44, IVL, MMP13, MMP7, MLH1
46cycloheximide32 4.9BCL2, BCL2L1, TGFA, OSM, SLC2A1, AGTR1
47paraffin32 4.2IVL, MMP1, MMP13, MMP7, MLH1, MKI67
48cisplatin32 34 9 9 7.2CDKN1A, CD44, MLH1, MKI67, AREG, CCNA2
49vegf32 3.4BCL2, BCL2L1, MUC1, JUP, CDKN1A, CD44
50serine32 2.8MSH6, JUP, NME1, SLC2A1, OSM, TGFA

GO Terms for genes affiliated with Keratoacanthoma

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Sources:
12Gene Ontology
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Cellular components related to keratoacanthoma according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1PCNA-p21 complexGO:07055710.2PCNA, CDKN1A
2desmosomeGO:0300579.9DSG3, DSG2, DSG1, JUP
3MutSalpha complexGO:0323019.8MSH2, MSH6
4intermediate filamentGO:0058829.8FLG, NME1, KRT14, KRT10, KRT17, KRT16
5cell-cell junctionGO:0059119.2SLC2A1, DSG2, DSG1, CTNNB1, JUP
6cytosolGO:0058296.2NME1, DSG3, DSG1, KRT14, CTNNB1, TP53
7cytoplasmGO:0057374.8TP53, TP63, PTGS2, CTNNB1, CRABP1, CRABP2

Biological processes related to keratoacanthoma according to GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:00629810.2PCNA, MSH2, MSH6
2somatic recombination of immunoglobulin gene segmentsGO:01644710.2MSH2, MSH6
3epidermis developmentGO:00854410.1CRABP2, KRT16, KRT17, KRT10, KRT14
4extracellular matrix disassemblyGO:02261710.0MMP1, MMP10, MMP13, MMP7
5response to UV-BGO:01022410.0IVL, MSH2, BCL2
6collagen catabolic processGO:0305749.9MMP7, MMP19, MMP13, MMP10, MMP1
7regulation of mitochondrial membrane potentialGO:0518819.7BAK1, BCL2L1, BCL2
8keratinocyte differentiationGO:0302169.6IVL, FLG, CASP3, TP63, KRT10
9determination of adult lifespanGO:0083409.6TP53, MSH6, MSH2
10cellular component disassembly involved in apoptotic processGO:0069219.4DSG3, DSG2, DSG1, CTNNB1, CASP3
11positive regulation of reactive oxygen species metabolic processGO:20003799.4AGTR1, TP53, CDKN1A
12B cell homeostasisGO:0017829.4CASP3, IKBKG, BAK1, BCL2
13response to organic cyclic compoundGO:0140709.3BAK1, MSH2, CDKN1A, PTGS2
14negative regulation of neuron apoptotic processGO:0435249.1BCL2, BCL2L1, MSH2, TGFA
15cell-cell adhesionGO:0163379.0DSG1, CTNNB1, CD44, JUP, BCL2
16response to gamma radiationGO:0103328.9BCL2, BAK1, TP53
17regulation of mitochondrial membrane permeabilityGO:0469028.9TP53, BAK1, BCL2L1, BCL2
18response to cytokine stimulusGO:0340978.7CTNNB1, PTGS2, BCL2L1, BCL2
19cell agingGO:0075698.6TP63, TP53, BCL2
20cell proliferationGO:0082838.6OSM, TGFA, KRT16, TP53, MKI67, BAK1
21neuron apoptotic processGO:0514028.5TP63, TP53, CASP3, BCL2
22release of cytochrome c from mitochondriaGO:0018368.4TP53, CASP3, BAK1, BCL2L1, BCL2
23negative regulation of cell proliferationGO:0082858.4NME1, OSM, CTNNB1, PTGS2, TP53, CDKN1A
24response to DNA damage stimulusGO:0069748.4TP53, CASP3, IKBKG, CDKN1A, BCL2
25response to drugGO:0424938.4NME1, TGFA, CTNNB1, PTGS2, MMP7, CDKN1A
26induction of apoptosis by intracellular signalsGO:0086298.0BCL2, TP53, CASP3, GZMB, CDKN1A, MSH6
27negative regulation of apoptotic processGO:0430667.8BCL2, BCL2L1, CDKN1A, CD44, CASP3, TP53
28apoptotic processGO:0069156.9OSM, DSG3, DSG2, DSG1, CTNNB1, TP63

Molecular functions related to keratoacanthoma according to GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1retinoid bindingGO:00550110.3CRABP2, CRABP1, RBP1
2MutLalpha complex bindingGO:03240510.3PCNA, MSH2, MSH6
3retinal bindingGO:01691810.3RBP1, CRABP1, CRABP2
4single thymine insertion bindingGO:03214310.3MSH6, MSH2
5mismatched DNA bindingGO:03098310.2MSH2, MSH6, MLH1
6retinol bindingGO:01984110.2RBP1, CRABP1, CRABP2
7oxidized purine DNA bindingGO:03235710.2MSH6, MSH2
8dinucleotide insertion or deletion bindingGO:03213910.2MSH2, PCNA
9single guanine insertion bindingGO:03214210.1MSH6, MSH2
10guanine/thymine mispair bindingGO:0321379.8MSH6, MSH2
11metalloendopeptidase activityGO:0042229.8MMP7, MMP19, MMP13, MMP10, MMP1
12calcium ion bindingGO:0055099.1DSG2, DSG1, FLG, MMP19, MMP13, MMP10
13protein heterodimerization activityGO:0469828.3AGTR1, TP53, CD3D, BAK1, BCL2L1, BCL2
14identical protein bindingGO:0428028.0NME1, SLC2A1, TP63, TP53, BAK1, BCL2L1
15protein bindingGO:0055154.2PCNA, IKBKG, CASP3, TP53, TP63, CTNNB1

Sources for Keratoacanthoma

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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