Aliases & Classifications for Keratoacanthoma

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Sources:
8Disease Ontology, 44Novoseek, 61UMLS, 56SNOMED-CT, 33MeSH, 39NCIt
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Aliases & Descriptions for Keratoacanthoma:

Name: Keratoacanthoma 8 44 61


External Ids:

Disease Ontology8 DOID:3149
MeSH33 D007636
NCIt39 C3146

Summaries for Keratoacanthoma

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Wikipedia:64 Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) skin tumour that is... more...

MalaCards based summary: Keratoacanthoma is related to muir-torre syndrome and lichen planus. An important gene associated with Keratoacanthoma is KRT10 (keratin 10), and among its related pathways are Granzyme Pathway and Telomere C-strand (Lagging Strand) Synthesis. The compounds isotretinoin and tcdd have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and bone, and related mouse phenotypes are tumorigenesis and cellular.

Related Diseases for Keratoacanthoma

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Diseases related to Keratoacanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1muir-torre syndrome30.9MLH1, MSH2
2lichen planus30.9GZMB, KRT10
3papilloma30.5KRT10
4psoriasis30.4GZMB, KRT17, KRT10
5steatocystoma multiplex30.3KRT17, KRT10
6laryngeal carcinoma30.2MKI67, NME1
7basal cell carcinoma30.1MKI67, MMP13, GZMB, KRT17, KRT10
8cervical squamous cell carcinoma30.1KRT10, MKI67, MLH1
9sarcoma29.5MSH2, MKI67, MLH1
10melanoma29.4MLH1, MKI67, MMP13, MSH2, NME1, GZMB
11transitional cell carcinoma29.3NME1, MSH2, MKI67, MLH1
12lung cancer29.2MLH1, MKI67, MMP13, NME1, GZMB
13leukemia29.2MLH1, MSH2, NME1, GZMB, KRT10
14adenocarcinoma28.7MLH1, MKI67, MMP13, MSH2, NME1, KRT17
15generalized eruptive keratoacanthoma10.5
16keratosis10.3
17lupus erythematosus10.3
18palmoplantar keratosis10.3KRT17, KRT10
19epidermolysis bullosa simplex10.3KRT10, KRT17
20sebaceous adenoma10.3MSH2
21peripheral t-cell lymphoma10.2GZMB, NME1
22discoid lupus erythematosus10.2
23endometrial cancer10.1NME1, MLH1
24actinic keratosis10.1
25vulvar keratoacanthoma-like carcinoma10.1
26multiple keratoacanthoma, ferguson-smith type10.1
27breast cancer10.1MKI67, NME1
28leukoplakia10.1NME1, MKI67
29smooth muscle tumor10.1MKI67, NME1
30breast fibroadenoma10.1MKI67, NME1
31tongue squamous cell carcinoma10.1MKI67, NME1
32bladder cancer, somatic10.1KRT10, MKI67
33bowen syndrome10.1MKI67, KRT17, KRT10
34cutaneous lupus erythematosus10.1
35verrucous carcinoma10.1
36sporotrichosis10.1
37cervicitis10.1
38laryngitis10.1
39mismatch repair cancer syndrome10.0MSH2, MLH1
40esophageal cancer10.0MMP13, NME1
41lynch syndrome10.0MLH1, MSH2
42sarcoma, synovial10.0MMP13, MKI67
43rectal neoplasm10.0MSH2, MLH1
44gastric adenocarcinoma10.0NME1, MMP13, MLH1
45squamous cell carcinoma, head and neck10.0MLH1, MMP13, NME1
46gallbladder cancer10.0NME1, MKI67, MLH1
47malignant fibroxanthoma10.0MSH2, MKI67
48laryngeal squamous cell carcinoma10.0NME1, MMP13, MKI67
49cervical cancer, somatic9.9MMP13, NME1, GZMB, KRT10
50rheumatoid arthritis9.9

Graphical network of the top 20 diseases related to Keratoacanthoma:



Diseases related to keratoacanthoma

Symptoms for Keratoacanthoma

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Drugs & Therapeutics for Keratoacanthoma

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Drug clinical trials:

Search ClinicalTrials for Keratoacanthoma

Search NIH Clinical Center for Keratoacanthoma

Genetic Tests for Keratoacanthoma

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Anatomical Context for Keratoacanthoma

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MalaCards organs/tissues related to Keratoacanthoma:

31
Skin, Lung, Bone, Colon, Bone marrow, Lymph node, Testes, Cervix, Myeloid, Tongue

Animal Models for Keratoacanthoma or affiliated genes

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MGI Mouse Phenotypes related to Keratoacanthoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9MLH1, MSH2, NME1, GZMB, KRT10
2MP:00053847.8KRT17, GZMB, MSH2, MMP13, MLH1
3MP:00107717.4KRT10, KRT17, NME1, MSH2, MMP13, MLH1
4MP:00107687.2MLH1, MSH2, NME1, GZMB, KRT17, KRT10

Publications for Keratoacanthoma

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Articles related to Keratoacanthoma:

(show top 50)    (show all 549)
idTitleAuthorsYear
1
Recurrent facial keratoacanthoma in a patient with diabetes: a case report. (24758418)
2014
2
Keratoacanthoma accompanied by multiple lung squamous cell carcinomas developing in a renal transplant recipient. (25120468)
2014
3
Plasmacytoid dendritic cell involvement in the host response against keratoacanthoma. (24831321)
2014
4
Metastatic laryngeal carcinoma mimicking eruptive keratoacanthomas: report of keratoacanthoma-like cutaneous metastases in a radiation port. (25244165)
2014
5
Keratoacanthoma with secondary ossification. (23231325)
2014
6
Generalized eruptive keratoacanthoma: a diagnostic and therapeutic challenge. (25070745)
2014
7
Ki-67 may be useful in differentiating between keratoacanthoma and cutaneous squamous cell carcinoma. (24524559)
2014
8
Two rare variants of keratoacanthoma in the same sign-out session. (24117878)
2013
9
Keratoacanthoma: an unusual nasal mass. (24376301)
2013
10
Spontaneous involution of keratoacanthoma, iconographic documentation and similarity with volcanoes of nature. (22570051)
2012
11
The nuclear factor kappa B p50 subunit and cortactin as markers to distinguish between keratoacanthoma and well-differentiated squamous cell carcinoma. (21883393)
2011
12
Keratoacanthoma of the head and neck with perineural invasion: incidental finding or cause for concern? (20653733)
2010
13
Cutaneous lupus erythematosus mimicking multiple keratoacanthomas. (19106056)
2009
14
Keratoacanthoma in a tattoo. (19903437)
2009
15
PGP 9.5 expression in cutaneous keratoacanthomas and squamous cell carcinomas. (19488775)
2009
16
A case of multiple keratoacanthomas associated with keratoacanthoma centrifugum marginatum. (16648927)
2006
17
HPV 6-positive giant keratoacanthoma in an immunocompetent patient. (16683389)
2006
18
Intralesional methotrexate for keratoacanthoma of the nose. (16276163)
2005
19
Imiquimod as a possible treatment for keratoacanthoma. (14964750)
2004
20
Multiple, keratoacanthoma-like nodules on a 47-year-old man: a rare presentation of cutaneous lupus erythematosus. (14636190)
2003
21
Keratoacanthoma developing on a pigmented patch in incontinentia pigmenti. (10828638)
2000
22
Malignant changes in a giant orbital keratoacanthoma developing over 25 years. (10794263)
2000
23
Multiple keratoacanthoma with neonatal onset in a girl. (10627223)
1999
24
Persistent keratoacanthoma: challenges in management. (9865205)
1998
25
Cutaneous sporotrichosis presenting as a keratoacanthoma. (9675531)
1998
26
Keratoacanthoma: is it a real entity? (9600429)
1998
27
Keratoacanthomas and lymphomatoid papulosis. (9700388)
1998
28
Generalized eruptive keratoacanthoma of Grzybowski: response to cyclophosphamide. (9146546)
1997
29
Microsatellite instability in keratoacanthoma. (8625045)
1995
30
Keratoacanthoma versus squamous cell carcinoma. An immunohistochemical reappraisal of p53 protein and proliferating cell nuclear antigen expression in keratoacanthoma-like tumors. (8600793)
1995
31
Subungual keratoacanthoma masquerading as a chronic paronychia. (7702309)
1995
32
Eruptive skin tags and keratoacanthomas in a patient with prolactinoma and colonic polyposis. (8075462)
1994
33
Nature of keratoacanthoma. (7943646)
1994
34
Basal cell carcinoma and keratoacanthoma in Hawaiians: an incidence report. (8227552)
1993
35
Generalized eruptive keratoacanthoma of Grzybowski. (8340502)
1993
36
DNA image cytometry of keratoacanthoma and squamous cell carcinoma. (1875048)
1991
37
Keratoacanthoma of the limbus. (3362498)
1988
38
Intralesional 5-fluorouracil for keratoacanthoma of the eyelid. (3154563)
1986
39
Is it skin cancer--or keratoacanthoma? (6468938)
1984
40
Keratoacanthoma. A clinical study. (6721538)
1984
41
Treatment of keratoacanthoma with intralesional bleomycin. (6194810)
1983
42
Squamous-cell carcinoma vs. keratoacanthoma. (7096765)
1982
43
Hypocomplementemia in keratoacanthoma. (7247456)
1981
44
Successful treatment of keratoacanthoma with intralesional fluorouracil. (7364978)
1980
45
Immune response to human keratoacanthoma. (394758)
1979
46
Conservative treatment of keratoacanthoma. (543623)
1979
47
Giant keratoacanthoma of the ear. (595076)
1977
48
Keratoacanthoma of the lower lip. Review of the literature and report of a case. (4531621)
1974
49
Epidermal antigens in experimental keratoacanthoma and squamous cell carcinoma. (4579775)
1973
50
Keratoacanthoma of nailbed: a report of two cases. (4704160)
1973

Variations for Keratoacanthoma

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Expression for genes affiliated with Keratoacanthoma

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Search GEO for disease gene expression data for Keratoacanthoma.

Pathways for genes affiliated with Keratoacanthoma

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Compounds for genes affiliated with Keratoacanthoma

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Compounds related to Keratoacanthoma according to GeneCards Suite gene sharing:

(show all 47)
idCompoundScoreTop Affiliating Genes
1isotretinoin44 1110.7MKI67, KRT10
2tcdd449.7KRT10, MMP13
3dutp449.6KRT10, MKI67
4p00001449.5MLH1, MKI67
5n-methyl-n-nitrosourea449.5MLH1, MSH2
6retinoid449.5KRT17, MMP13, KRT10
7glyceraldehyde 3-phosphate449.5MMP13, NME1, KRT10
8mononucleotide449.5MSH2, MLH1
96 thioguanine449.5MLH1, MSH2
10mnng449.4MSH2, MLH1
11agarose449.4MLH1, MMP13, GZMB
12temozolomide44 1110.4MLH1, MSH2
13hematoxylin449.4KRT10, MKI67
14etoposide44 50 60 1112.4GZMB, MLH1, NME1
15ribonucleic acid449.4NME1, MMP13, GZMB
16bromodeoxyuridine449.4KRT10, MLH1, MKI67
17o6-methylguanine449.4MSH2, MLH1
18chi 2449.3MLH1, MKI67, NME1
19carboplatin44 50 1111.1MSH2, MLH1
20dexamethasone44 50 28 1112.1MMP13, NME1, KRT10, GZMB
21crcs449.1MSH2, MLH1, NME1
22oligonucleotide449.1KRT17, MMP13, GZMB, NME1
23irinotecan44 50 1111.0MKI67, MLH1
24lactate449.0MKI67, NME1, GZMB
25fatty acid448.9MKI67, MLH1, NME1, KRT10
26progesterone44 28 60 24 1112.9NME1, MLH1, MKI67, KRT10
27thymidylate448.9MSH2, MKI67, MLH1
28nitric oxide44 24 1110.8NME1, MMP13, MKI67, GZMB
29p002448.8NME1, MMP13, MKI67, MLH1
30thymidine44 249.7MMP13, MKI67, MLH1, NME1
31doxorubicin44 50 1110.7MSH2, MKI67, MLH1
32oxygen44 249.6MKI67, MLH1, GZMB, MMP13
33alanine448.6GZMB, NME1, MLH1, MSH2
34steroid448.6KRT10, GZMB, MKI67, MLH1, NME1
35proline448.6MSH2, MKI67, MLH1, KRT10
36biotin44 24 1110.5NME1, MKI67, MLH1, MSH2
375fluorouracil448.5MLH1, NME1, MSH2, MKI67
38vegf448.4GZMB, MLH1, NME1, MMP13, MKI67
39atp44 289.3KRT17, GZMB, NME1, MLH1, MSH2
40arginine448.2KRT10, MSH2, MLH1, MKI67, GZMB
41cisplatin44 50 60 1111.1NME1, MKI67, MLH1, GZMB, MSH2
42estrogen448.1NME1, MKI67, KRT10, GZMB, MLH1, MMP13
43calcium44 50 24 1111.0MKI67, GZMB, KRT10, MMP13, NME1, MLH1
44retinoic acid44 248.7MLH1, MKI67, MMP13, NME1, KRT10, KRT17
45tyrosine447.7MKI67, KRT10, KRT17, GZMB, NME1, MLH1
46serine447.4MKI67, KRT10, MMP13, MSH2, NME1, GZMB
47paraffin446.8NME1, GZMB, KRT17, KRT10, MSH2, MKI67

GO Terms for genes affiliated with Keratoacanthoma

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Cellular components related to Keratoacanthoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.7KRT10, KRT17

Biological processes related to Keratoacanthoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:00062989.1MSH2, MLH1
2somatic hypermutation of immunoglobulin genesGO:00164469.0MSH2, MLH1
3isotype switchingGO:00451908.8MSH2, MLH1

Molecular functions related to Keratoacanthoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1guanine/thymine mispair bindingGO:00321378.8MSH2, MLH1
2single-stranded DNA bindingGO:00036978.6NME1, MSH2, MLH1
3ATP bindingGO:00055248.1NME1, MSH2, MKI67, MLH1

Sources for Keratoacanthoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet