MCID: KRT005
MIFTS: 40

Keratoacanthoma malady

Summaries for Keratoacanthoma

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Wikipedia:63 Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) skin tumour that is... more...

MalaCards based summary: Keratoacanthoma is related to muir-torre syndrome and lichen planus. An important gene associated with Keratoacanthoma is KRT10 (keratin 10), and among its related pathways are Granzyme Pathway and Telomere C-strand (Lagging Strand) Synthesis. The compounds isotretinoin and tcdd have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and bone, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Keratoacanthoma

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt
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Keratoacanthoma, Aliases & Descriptions:

Name: Keratoacanthoma 9 43 60


External Ids:

Disease Ontology9 DOID:3149
MeSH33 D007636
NCIt38 C3146

Related Diseases for Keratoacanthoma

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Diseases related to Keratoacanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1muir-torre syndrome30.9MLH1, MSH2
2lichen planus30.9GZMB, KRT10
3papilloma30.5KRT10
4psoriasis30.4GZMB, KRT17, KRT10
5steatocystoma multiplex30.3KRT17, KRT10
6laryngeal carcinoma30.2MKI67, NME1
7basal cell carcinoma30.1MKI67, MMP13, GZMB, KRT17, KRT10
8cervical squamous cell carcinoma30.1KRT10, MKI67, MLH1
9sarcoma29.5MSH2, MKI67, MLH1
10melanoma29.4MLH1, MKI67, MMP13, MSH2, NME1, GZMB
11transitional cell carcinoma29.3NME1, MSH2, MKI67, MLH1
12lung cancer29.2MLH1, MKI67, MMP13, NME1, GZMB
13leukemia29.2MLH1, MSH2, NME1, GZMB, KRT10
14adenocarcinoma28.7MLH1, MKI67, MMP13, MSH2, NME1, KRT17
15generalized eruptive keratoacanthoma10.5
16keratosis10.3
17lupus erythematosus10.3
18palmoplantar keratosis10.3KRT17, KRT10
19epidermolysis bullosa simplex10.3KRT10, KRT17
20sebaceous adenoma10.3MSH2
21peripheral t-cell lymphoma10.2GZMB, NME1
22discoid lupus erythematosus10.2
23endometrial cancer10.1NME1, MLH1
24actinic keratosis10.1
25vulvar keratoacanthoma-like carcinoma10.1
26multiple keratoacanthoma, ferguson-smith type10.1
27breast cancer10.1MKI67, NME1
28leukoplakia10.1NME1, MKI67
29smooth muscle tumor10.1MKI67, NME1
30breast fibroadenoma10.1MKI67, NME1
31tongue squamous cell carcinoma10.1MKI67, NME1
32bladder cancer, somatic10.1KRT10, MKI67
33bowen syndrome10.1MKI67, KRT17, KRT10
34cutaneous lupus erythematosus10.1
35verrucous carcinoma10.1
36sporotrichosis10.1
37cervicitis10.1
38laryngitis10.1
39mismatch repair cancer syndrome10.0MSH2, MLH1
40esophageal cancer10.0MMP13, NME1
41lynch syndrome10.0MLH1, MSH2
42sarcoma, synovial10.0MMP13, MKI67
43rectal neoplasm10.0MSH2, MLH1
44gastric adenocarcinoma10.0NME1, MMP13, MLH1
45squamous cell carcinoma, head and neck10.0MLH1, MMP13, NME1
46gallbladder cancer10.0NME1, MKI67, MLH1
47malignant fibroxanthoma10.0MSH2, MKI67
48laryngeal squamous cell carcinoma10.0NME1, MMP13, MKI67
49cervical cancer, somatic9.9MMP13, NME1, GZMB, KRT10
50rheumatoid arthritis9.9

Graphical network of the top 20 diseases related to Keratoacanthoma:



Diseases related to keratoacanthoma

Symptoms for Keratoacanthoma

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Drugs & Therapeutics for Keratoacanthoma

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Drug clinical trials:

Search ClinicalTrials for Keratoacanthoma

Search NIH Clinical Center for Keratoacanthoma

Genetic Tests for Keratoacanthoma

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Anatomical Context for Keratoacanthoma

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MalaCards organs/tissues related to Keratoacanthoma:

31
Skin, Lung, Bone, Colon, Bone marrow, Lymph node, Testes, Cervix, Myeloid, Tongue

Animal Models for Keratoacanthoma or affiliated genes

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MGI Mouse Phenotypes related to Keratoacanthoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9MLH1, MSH2, NME1, GZMB, KRT10
2MP:00053847.8KRT17, GZMB, MSH2, MMP13, MLH1
3MP:00107717.4KRT10, KRT17, NME1, MSH2, MMP13, MLH1
4MP:00107687.2MLH1, MSH2, NME1, GZMB, KRT17, KRT10

Publications for Keratoacanthoma

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Articles related to Keratoacanthoma:

(show top 50)    (show all 549)
idTitleAuthorsYear
1
Recurrent facial keratoacanthoma in a patient with diabetes: a case report. (24758418)
2014
2
Keratoacanthoma accompanied by multiple lung squamous cell carcinomas developing in a renal transplant recipient. (25120468)
2014
3
Plasmacytoid dendritic cell involvement in the host response against keratoacanthoma. (24831321)
2014
4
Metastatic laryngeal carcinoma mimicking eruptive keratoacanthomas: report of keratoacanthoma-like cutaneous metastases in a radiation port. (25244165)
2014
5
Keratoacanthoma with secondary ossification. (23231325)
2014
6
Generalized eruptive keratoacanthoma: a diagnostic and therapeutic challenge. (25070745)
2014
7
Ki-67 may be useful in differentiating between keratoacanthoma and cutaneous squamous cell carcinoma. (24524559)
2014
8
Two rare variants of keratoacanthoma in the same sign-out session. (24117878)
2013
9
Keratoacanthoma: an unusual nasal mass. (24376301)
2013
10
Spontaneous involution of keratoacanthoma, iconographic documentation and similarity with volcanoes of nature. (22570051)
2012
11
The nuclear factor kappa B p50 subunit and cortactin as markers to distinguish between keratoacanthoma and well-differentiated squamous cell carcinoma. (21883393)
2011
12
Keratoacanthoma of the head and neck with perineural invasion: incidental finding or cause for concern? (20653733)
2010
13
Cutaneous lupus erythematosus mimicking multiple keratoacanthomas. (19106056)
2009
14
Keratoacanthoma in a tattoo. (19903437)
2009
15
PGP 9.5 expression in cutaneous keratoacanthomas and squamous cell carcinomas. (19488775)
2009
16
A case of multiple keratoacanthomas associated with keratoacanthoma centrifugum marginatum. (16648927)
2006
17
HPV 6-positive giant keratoacanthoma in an immunocompetent patient. (16683389)
2006
18
Intralesional methotrexate for keratoacanthoma of the nose. (16276163)
2005
19
Imiquimod as a possible treatment for keratoacanthoma. (14964750)
2004
20
Multiple, keratoacanthoma-like nodules on a 47-year-old man: a rare presentation of cutaneous lupus erythematosus. (14636190)
2003
21
Keratoacanthoma developing on a pigmented patch in incontinentia pigmenti. (10828638)
2000
22
Malignant changes in a giant orbital keratoacanthoma developing over 25 years. (10794263)
2000
23
Multiple keratoacanthoma with neonatal onset in a girl. (10627223)
1999
24
Persistent keratoacanthoma: challenges in management. (9865205)
1998
25
Cutaneous sporotrichosis presenting as a keratoacanthoma. (9675531)
1998
26
Keratoacanthoma: is it a real entity? (9600429)
1998
27
Keratoacanthomas and lymphomatoid papulosis. (9700388)
1998
28
Generalized eruptive keratoacanthoma of Grzybowski: response to cyclophosphamide. (9146546)
1997
29
Microsatellite instability in keratoacanthoma. (8625045)
1995
30
Keratoacanthoma versus squamous cell carcinoma. An immunohistochemical reappraisal of p53 protein and proliferating cell nuclear antigen expression in keratoacanthoma-like tumors. (8600793)
1995
31
Subungual keratoacanthoma masquerading as a chronic paronychia. (7702309)
1995
32
Eruptive skin tags and keratoacanthomas in a patient with prolactinoma and colonic polyposis. (8075462)
1994
33
Nature of keratoacanthoma. (7943646)
1994
34
Basal cell carcinoma and keratoacanthoma in Hawaiians: an incidence report. (8227552)
1993
35
Generalized eruptive keratoacanthoma of Grzybowski. (8340502)
1993
36
DNA image cytometry of keratoacanthoma and squamous cell carcinoma. (1875048)
1991
37
Keratoacanthoma of the limbus. (3362498)
1988
38
Intralesional 5-fluorouracil for keratoacanthoma of the eyelid. (3154563)
1986
39
Is it skin cancer--or keratoacanthoma? (6468938)
1984
40
Keratoacanthoma. A clinical study. (6721538)
1984
41
Treatment of keratoacanthoma with intralesional bleomycin. (6194810)
1983
42
Squamous-cell carcinoma vs. keratoacanthoma. (7096765)
1982
43
Hypocomplementemia in keratoacanthoma. (7247456)
1981
44
Successful treatment of keratoacanthoma with intralesional fluorouracil. (7364978)
1980
45
Immune response to human keratoacanthoma. (394758)
1979
46
Conservative treatment of keratoacanthoma. (543623)
1979
47
Giant keratoacanthoma of the ear. (595076)
1977
48
Keratoacanthoma of the lower lip. Review of the literature and report of a case. (4531621)
1974
49
Epidermal antigens in experimental keratoacanthoma and squamous cell carcinoma. (4579775)
1973
50
Keratoacanthoma of nailbed: a report of two cases. (4704160)
1973

Variations for Keratoacanthoma

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Expression for genes affiliated with Keratoacanthoma

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Search GEO for disease gene expression data for Keratoacanthoma.

Pathways for genes affiliated with Keratoacanthoma

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Compounds for genes affiliated with Keratoacanthoma

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Compounds related to Keratoacanthoma according to GeneCards Suite gene sharing:

(show all 47)
idCompoundScoreTop Affiliating Genes
1isotretinoin43 1210.7MKI67, KRT10
2tcdd439.7MMP13, KRT10
3dutp439.6MKI67, KRT10
4p00001439.5MKI67, MLH1
5n-methyl-n-nitrosourea439.5MLH1, MSH2
6retinoid439.5KRT10, KRT17, MMP13
7glyceraldehyde 3-phosphate439.5KRT10, NME1, MMP13
8mononucleotide439.5MLH1, MSH2
96 thioguanine439.5MLH1, MSH2
10mnng439.4MLH1, MSH2
11agarose439.4MLH1, MMP13, GZMB
12temozolomide43 1210.4MSH2, MLH1
13hematoxylin439.4MKI67, KRT10
14etoposide43 49 59 1212.4MLH1, NME1, GZMB
15ribonucleic acid439.4GZMB, NME1, MMP13
16bromodeoxyuridine439.4KRT10, MKI67, MLH1
17o6-methylguanine439.4MLH1, MSH2
18chi 2439.3MLH1, MKI67, NME1
19carboplatin43 49 1211.1MSH2, MLH1
20dexamethasone43 49 28 1212.1MMP13, NME1, GZMB, KRT10
21crcs439.1NME1, MSH2, MLH1
22oligonucleotide439.1KRT17, GZMB, NME1, MMP13
23irinotecan43 49 1211.0MKI67, MLH1
24lactate439.0GZMB, NME1, MKI67
25fatty acid438.9MLH1, MKI67, NME1, KRT10
26progesterone43 28 59 24 1212.9KRT10, NME1, MKI67, MLH1
27thymidylate438.9MSH2, MKI67, MLH1
28nitric oxide43 24 1210.8GZMB, NME1, MMP13, MKI67
29p002438.8NME1, MMP13, MKI67, MLH1
30thymidine43 249.7MLH1, MKI67, MMP13, NME1
31doxorubicin43 49 1210.7MSH2, MKI67, MLH1
32oxygen43 249.6MLH1, MKI67, MMP13, GZMB
33alanine438.6MLH1, MSH2, NME1, GZMB
34steroid438.6KRT10, GZMB, NME1, MKI67, MLH1
35proline438.6KRT10, MSH2, MKI67, MLH1
36biotin43 24 1210.5MLH1, MKI67, MSH2, NME1
375fluorouracil438.5MLH1, MKI67, MSH2, NME1
38vegf438.4MLH1, MKI67, MMP13, NME1, GZMB
39atp43 289.3MLH1, MSH2, NME1, GZMB, KRT17
40arginine438.2KRT10, GZMB, MSH2, MKI67, MLH1
41cisplatin43 49 59 1211.1MLH1, MKI67, MSH2, NME1, GZMB
42estrogen438.1MLH1, MKI67, MMP13, NME1, GZMB, KRT10
43calcium43 49 24 1211.0MLH1, MKI67, MMP13, NME1, GZMB, KRT10
44retinoic acid43 248.7MLH1, MKI67, MMP13, NME1, GZMB, KRT17
45tyrosine437.7MLH1, MKI67, MMP13, NME1, GZMB, KRT17
46serine437.4MKI67, MMP13, MSH2, NME1, GZMB, KRT17
47paraffin436.8KRT10, MLH1, MKI67, MMP13, MSH2, NME1

GO Terms for genes affiliated with Keratoacanthoma

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Cellular components related to Keratoacanthoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.7KRT10, KRT17

Biological processes related to Keratoacanthoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:00062989.1MSH2, MLH1
2somatic hypermutation of immunoglobulin genesGO:00164469.0MSH2, MLH1
3isotype switchingGO:00451908.8MSH2, MLH1

Molecular functions related to Keratoacanthoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1guanine/thymine mispair bindingGO:00321378.8MSH2, MLH1
2single-stranded DNA bindingGO:00036978.6NME1, MSH2, MLH1
3ATP bindingGO:00055248.1NME1, MSH2, MKI67, MLH1

Products for genes affiliated with Keratoacanthoma

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Sources for Keratoacanthoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet