MCID: KRT005
MIFTS: 51

Keratoacanthoma malady

Genetic diseases, Cancer diseases, Eye diseases, Skin diseases, Rare diseases categories
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Summaries for Keratoacanthoma

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Wikipedia:65 Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) skin tumour that is... more...

MalaCards based summary: Keratoacanthoma is related to lichen planus and muir-torre syndrome. An important gene associated with Keratoacanthoma is KRT10 (keratin 10), and among its related pathways are Granzyme Pathway and Telomere C-strand (Lagging Strand) Synthesis. The compounds isotretinoin and tcdd have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and bone, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Keratoacanthoma

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH
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Keratoacanthoma, Aliases & Descriptions:

Name: Keratoacanthoma 8 44 62


Classifications:



External Ids:

Disease Ontology8 DOID:3149
NCIt39 C3146
MeSH34 D007636

Related Diseases for Keratoacanthoma

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Diseases in the Familial Keratoacanthoma family:

keratoacanthoma

Diseases related to Keratoacanthoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1lichen planus30.8GZMB, KRT10
2muir-torre syndrome30.7MLH1, MSH2
3papilloma30.6KRT10
4psoriasis30.4GZMB, KRT17, KRT10
5steatocystoma multiplex30.3KRT17, KRT10
6cervical squamous cell carcinoma30.1KRT10, MKI67, MLH1
7basal cell carcinoma30.1MKI67, MMP13, GZMB, KRT17, KRT10
8sarcoma29.5MSH2, MKI67, MLH1
9melanoma29.4MLH1, MKI67, MMP13, MSH2, NME1, GZMB
10transitional cell carcinoma29.3NME1, MSH2, MKI67, MLH1
11leukemia29.2MLH1, MSH2, NME1, GZMB, KRT10
12adenocarcinoma28.7MLH1, MKI67, MMP13, MSH2, NME1, KRT17
13generalized eruptive keratoacanthoma10.5
14turcot syndrome10.4MLH1
15palmoplantar keratosis10.3KRT17, KRT10
16epidermolysis bullosa simplex10.3KRT10, KRT17
17keratosis10.3
18lupus erythematosus10.3
19familial keratoacanthoma10.3
20sebaceous adenoma10.3MSH2
21peripheral t-cell lymphoma10.2GZMB, NME1
22discoid lupus erythematosus10.2
23endometrial carcinoma10.2NME1, MLH1
24breast cancer, invasive ductal10.2MKI67, NME1
25leukoplakia10.2NME1, MKI67
26smooth muscle tumor10.1MKI67, NME1
27breast fibroadenoma10.1MKI67, NME1
28actinic keratosis10.1
29tongue squamous cell carcinoma10.1MKI67, NME1
30bladder carcinoma10.1KRT10, MKI67
31laryngeal benign neoplasm10.1MKI67, NME1
32bowen syndrome10.1MKI67, KRT17, KRT10
33vitiligo10.1
34vulvar keratoacanthoma-like carcinoma10.1
35sporotrichosis10.1
36cutaneous lupus erythematosus10.1
37cervicitis10.1
38laryngeal carcinoma10.1
39laryngitis10.1
40epidermal nevus10.1
41multiple self-healing squamous epithelioma, susceptiblity to10.1
42familial colorectal cancer10.1MSH2, MLH1
43esophageal cancer10.0MMP13, NME1
44lynch syndrome10.0MLH1, MSH2
45synovial sarcoma10.0MMP13, MKI67
46rectal neoplasm10.0MSH2, MLH1
47gastric adenocarcinoma10.0NME1, MMP13, MLH1
48squamous cell carcinoma of the head and neck10.0MLH1, MMP13, NME1
49gallbladder cancer10.0NME1, MKI67, MLH1
50malignant fibroxanthoma10.0MSH2, MKI67

Graphical network of the top 20 diseases related to Keratoacanthoma:



Diseases related to keratoacanthoma

Symptoms for Keratoacanthoma

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Drugs & Therapeutics for Keratoacanthoma

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Drug clinical trials:

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Search NIH Clinical Center for Keratoacanthoma

Genetic Tests for Keratoacanthoma

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Anatomical Context for Keratoacanthoma

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MalaCards organs/tissues related to Keratoacanthoma:

32
Skin, Lung, Bone, Colon, Bone marrow, Lymph node, Smooth muscle, Testes, Cervix, Myeloid, Tongue

Animal Models for Keratoacanthoma or affiliated genes

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MGI Mouse Phenotypes related to Keratoacanthoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9MLH1, MSH2, NME1, GZMB, KRT10
2MP:00053847.8KRT17, GZMB, MSH2, MMP13, MLH1
3MP:00107717.4KRT10, KRT17, NME1, MSH2, MMP13, MLH1
4MP:00107687.2MLH1, MSH2, NME1, GZMB, KRT17, KRT10

Publications for Keratoacanthoma

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Articles related to Keratoacanthoma:

(show top 50)    (show all 542)
idTitleAuthorsYear
1
Recurrent facial keratoacanthoma in a patient with diabetes: a case report. (24758418)
2014
2
Keratoacanthoma accompanied by multiple lung squamous cell carcinomas developing in a renal transplant recipient. (25120468)
2014
3
Plasmacytoid dendritic cell involvement in the host response against keratoacanthoma. (24831321)
2014
4
Metastatic laryngeal carcinoma mimicking eruptive keratoacanthomas: report of keratoacanthoma-like cutaneous metastases in a radiation port. (25244165)
2014
5
Keratoacanthoma with secondary ossification. (23231325)
2014
6
Generalized eruptive keratoacanthoma: a diagnostic and therapeutic challenge. (25070745)
2014
7
Ki-67 may be useful in differentiating between keratoacanthoma and cutaneous squamous cell carcinoma. (24524559)
2014
8
Two rare variants of keratoacanthoma in the same sign-out session. (24117878)
2013
9
Spontaneous involution of keratoacanthoma, iconographic documentation and similarity with volcanoes of nature. (22570051)
2012
10
The nuclear factor kappa B p50 subunit and cortactin as markers to distinguish between keratoacanthoma and well-differentiated squamous cell carcinoma. (21883393)
2011
11
Keratoacanthoma of the head and neck with perineural invasion: incidental finding or cause for concern? (20653733)
2010
12
Cutaneous lupus erythematosus mimicking multiple keratoacanthomas. (19106056)
2009
13
Keratoacanthoma in a tattoo. (19903437)
2009
14
PGP 9.5 expression in cutaneous keratoacanthomas and squamous cell carcinomas. (19488775)
2009
15
A case of multiple keratoacanthomas associated with keratoacanthoma centrifugum marginatum. (16648927)
2006
16
HPV 6-positive giant keratoacanthoma in an immunocompetent patient. (16683389)
2006
17
Intralesional methotrexate for keratoacanthoma of the nose. (16276163)
2005
18
Imiquimod as a possible treatment for keratoacanthoma. (14964750)
2004
19
Multiple, keratoacanthoma-like nodules on a 47-year-old man: a rare presentation of cutaneous lupus erythematosus. (14636190)
2003
20
Keratoacanthoma developing on a pigmented patch in incontinentia pigmenti. (10828638)
2000
21
Malignant changes in a giant orbital keratoacanthoma developing over 25 years. (10794263)
2000
22
Multiple keratoacanthoma with neonatal onset in a girl. (10627223)
1999
23
Persistent keratoacanthoma: challenges in management. (9865205)
1998
24
Cutaneous sporotrichosis presenting as a keratoacanthoma. (9675531)
1998
25
Keratoacanthoma: is it a real entity? (9600429)
1998
26
Keratoacanthomas and lymphomatoid papulosis. (9700388)
1998
27
Generalized eruptive keratoacanthoma of Grzybowski: response to cyclophosphamide. (9146546)
1997
28
Microsatellite instability in keratoacanthoma. (8625045)
1995
29
Keratoacanthoma versus squamous cell carcinoma. An immunohistochemical reappraisal of p53 protein and proliferating cell nuclear antigen expression in keratoacanthoma-like tumors. (8600793)
1995
30
Subungual keratoacanthoma masquerading as a chronic paronychia. (7702309)
1995
31
Eruptive skin tags and keratoacanthomas in a patient with prolactinoma and colonic polyposis. (8075462)
1994
32
Nature of keratoacanthoma. (7943646)
1994
33
Basal cell carcinoma and keratoacanthoma in Hawaiians: an incidence report. (8227552)
1993
34
Generalized eruptive keratoacanthoma of Grzybowski. (8340502)
1993
35
DNA image cytometry of keratoacanthoma and squamous cell carcinoma. (1875048)
1991
36
Keratoacanthoma versus squamous cell carcinoma of the lower lip. (2189352)
1990
37
Keratoacanthoma of the limbus. (3362498)
1988
38
Intralesional 5-fluorouracil for keratoacanthoma of the eyelid. (3154563)
1986
39
Is it skin cancer--or keratoacanthoma? (6468938)
1984
40
Treatment of keratoacanthoma with intralesional bleomycin. (6194810)
1983
41
Squamous-cell carcinoma vs. keratoacanthoma. (7096765)
1982
42
Hypocomplementemia in keratoacanthoma. (7247456)
1981
43
Keratoacanthoma of the head and neck. (7356269)
1980
44
Successful treatment of keratoacanthoma with intralesional fluorouracil. (7364978)
1980
45
Immune response to human keratoacanthoma. (394758)
1979
46
Conservative treatment of keratoacanthoma. (543623)
1979
47
Giant keratoacanthoma of the ear. (595076)
1977
48
Keratoacanthoma of the lower lip. Review of the literature and report of a case. (4531621)
1974
49
Epidermal antigens in experimental keratoacanthoma and squamous cell carcinoma. (4579775)
1973
50
Keratoacanthoma of nailbed: a report of two cases. (4704160)
1973

Variations for Keratoacanthoma

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Expression for genes affiliated with Keratoacanthoma

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Expression patterns in normal tissues for genes affiliated with Keratoacanthoma

Search GEO for disease gene expression data for Keratoacanthoma.

Pathways for genes affiliated with Keratoacanthoma

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Compounds for genes affiliated with Keratoacanthoma

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Compounds related to Keratoacanthoma according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1isotretinoin44 1110.7MKI67, KRT10
2tcdd449.7MMP13, KRT10
3dutp449.6MKI67, KRT10
4p00001449.5MKI67, MLH1
5n-methyl-n-nitrosourea449.5MLH1, MSH2
6retinoid449.5KRT10, KRT17, MMP13
7glyceraldehyde 3-phosphate449.5KRT10, NME1, MMP13
8mononucleotide449.5MLH1, MSH2
96 thioguanine449.5MLH1, MSH2
10mnng449.4MLH1, MSH2
11agarose449.4MLH1, MMP13, GZMB
12temozolomide44 1110.4MSH2, MLH1
13hematoxylin449.4MKI67, KRT10
14etoposide44 50 61 1112.4MLH1, NME1, GZMB
15ribonucleic acid449.4GZMB, NME1, MMP13
16bromodeoxyuridine449.4KRT10, MKI67, MLH1
17o6-methylguanine449.4MLH1, MSH2
18chi 2449.3MLH1, MKI67, NME1
19carboplatin44 50 1111.1MSH2, MLH1
20dexamethasone44 50 28 1112.1MMP13, NME1, GZMB, KRT10
21crcs449.1NME1, MSH2, MLH1
22oligonucleotide449.1KRT17, GZMB, NME1, MMP13
23irinotecan44 50 1111.0MKI67, MLH1
24lactate449.0GZMB, NME1, MKI67
25fatty acid448.9MLH1, MKI67, NME1, KRT10
26progesterone44 28 61 24 1112.9KRT10, NME1, MKI67, MLH1
27thymidylate448.9MSH2, MKI67, MLH1
28nitric oxide44 24 1110.8GZMB, NME1, MMP13, MKI67
29p002448.8NME1, MMP13, MKI67, MLH1
30thymidine44 249.7MLH1, MKI67, MMP13, NME1
31doxorubicin44 50 1110.7MSH2, MKI67, MLH1
32oxygen44 249.6MLH1, MKI67, MMP13, GZMB
33alanine448.6MLH1, MSH2, NME1, GZMB
34steroid448.6KRT10, GZMB, NME1, MKI67, MLH1
35proline448.6KRT10, MSH2, MKI67, MLH1
36biotin44 24 1110.5MLH1, MKI67, MSH2, NME1
375fluorouracil448.5MLH1, MKI67, MSH2, NME1
38vegf448.4MLH1, MKI67, MMP13, NME1, GZMB
39atp44 289.3MLH1, MSH2, NME1, GZMB, KRT17
40arginine448.2KRT10, GZMB, MSH2, MKI67, MLH1
41cisplatin44 50 61 1111.1MLH1, MKI67, MSH2, NME1, GZMB
42estrogen448.1MLH1, MKI67, MMP13, NME1, GZMB, KRT10
43calcium44 50 24 1111.0MLH1, MKI67, MMP13, NME1, GZMB, KRT10
44retinoic acid44 248.7MLH1, MKI67, MMP13, NME1, GZMB, KRT17
45tyrosine447.7MLH1, MKI67, MMP13, NME1, GZMB, KRT17
46serine447.4MKI67, MMP13, MSH2, NME1, GZMB, KRT17
47paraffin446.8KRT10, MLH1, MKI67, MMP13, MSH2, NME1

GO Terms for genes affiliated with Keratoacanthoma

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Cellular components related to Keratoacanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.7KRT10, KRT17

Biological processes related to Keratoacanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:0062989.1MSH2, MLH1
2somatic hypermutation of immunoglobulin genesGO:0164469.0MSH2, MLH1
3isotype switchingGO:0451908.8MSH2, MLH1

Molecular functions related to Keratoacanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1guanine/thymine mispair bindingGO:0321378.8MSH2, MLH1
2single-stranded DNA bindingGO:0036978.6NME1, MSH2, MLH1
3ATP bindingGO:0055248.1NME1, MSH2, MKI67, MLH1

Products for genes affiliated with Keratoacanthoma

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Sources for Keratoacanthoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet