MCID: KRT005
MIFTS: 53

Keratoacanthoma malady

Summaries for Keratoacanthoma

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) skin tumour that is... more...

MalaCards: Keratoacanthoma is related to squamous cell carcinoma and muir-torre syndrome. An important gene associated with Keratoacanthoma is KRT10 (keratin 10), and among its related pathways are Lagging Strand Synthesis and Matrix Metalloproteinases. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and bone, and related mouse phenotypes are limbs/digits/tail and integument.

Aliases & Classifications for Keratoacanthoma

About this section
Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
See all sources

Aliases & Descriptions:

keratoacanthoma 8 44 60


External Ids:

Disease Ontology8 DOID:3149
NCIt39 C3146
MeSH34 D007636

Related Diseases for Keratoacanthoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Familial Keratoacanthoma family:

keratoacanthoma

Diseases related to Keratoacanthoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.3CRABP1, MKI67, MMP10, MMP19, NME1
2muir-torre syndrome30.5MLH1, MSH2
3basal cell carcinoma30.4KRT17, KRT10, KRT16, MMP13, MKI67, BAK1
4melanoma30.4BAK1, MLH1, AREG, GZMB, MKI67, CDKN1A
5keratosis30.3IVL, KRT16, KRT10
6lichen planus30.3GZMB, IVL, DSG3, KRT16, KRT10
7papilloma30.1AREG, IVL, BAK1, CDKN1A, PCNA, KRT10
8psoriasis30.1KRT17, KRT10, KRT16, MMP19, BAK1, IVL
9cervical squamous cell carcinoma30.0MLH1, IVL, MKI67, CDKN1A, KRT10
10adenocarcinoma30.0IVL, MLH1, AREG, DSG3, BAK1, MSH2
11skin melanoma29.7NME1
12sarcoma29.7MSH2, MKI67, MLH1
13arthritis29.7GZMB, MMP13, MMP10
14chondrosarcoma29.7MMP13
15dermatitis29.7KRT16, DSG3, IVL, GZMB
16rheumatoid arthritis29.7GZMB, AREG, MMP13, MMP19
17bladder carcinoma29.7AREG, MKI67, CDKN1A, PCNA
18lung cancer29.7IVL, BAK1, CDKN1A, PCNA, NME1
19transitional cell carcinoma29.7MLH1, MKI67, CDKN1A, PCNA, NME1, MSH2
20skin disease29.7AREG, CRABP2, IVL, DSG3, KRT16, KRT10
21myeloma29.7CDKN1A, BAK1, AREG
22leukemia29.7GZMB, AREG, MLH1, IVL, BAK1, CDKN1A
23skin squamous cell carcinoma10.5
24lupus erythematosus10.2
25verrucous carcinoma10.1
26in situ carcinoma10.1
27familial keratoacanthoma10.1
28actinic keratosis10.1
29cutaneous lupus erythematosus10.0
30vulvar keratoacanthoma-like carcinoma10.0
31sporotrichosis10.0
32vitiligo10.0
33cervicitis10.0
34multiple self-healing squamous epithelioma, susceptiblity to10.0
35gingivitis10.0MMP13
36hepatitis10.0GZMB
37gallbladder cancer10.0MLH1
38severe combined immunodeficiency10.0CD3D
39tongue cancer10.0CDKN1A
40malignant mesothelioma10.0AREG
41gastrointestinal stromal tumor10.0PCNA, MKI67
42neuroblastoma10.0NME1
43wilms tumor10.0AREG
44deficiency anemia10.0AREG
45sebaceous adenoma10.0MSH2
46epidermolytic hyperkeratosis10.0KRT16, KRT10
47teratocarcinoma10.0CRABP1
48gastritis10.0PCNA, AREG
49monilethrix10.0KRT17, KRT16
50cystadenocarcinoma10.0AREG

Graphical network of the top 20 diseases related to Keratoacanthoma:



Diseases related to keratoacanthoma

Clinical Features for Keratoacanthoma

About this section

Drugs & Therapeutics for Keratoacanthoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Keratoacanthoma

Drug clinical trials:

Search ClinicalTrials for Keratoacanthoma

Search NIH Clinical Center for Keratoacanthoma

Search CenterWatch for Keratoacanthoma

Genetic Tests for Keratoacanthoma

About this section

Anatomical Context for Keratoacanthoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Keratoacanthoma:

32
Skin, Lung, Bone, Colon, Myeloid, Cervix, Testes, Bone marrow, Smooth muscle, Lymph node, Tongue

Animal Models for Keratoacanthoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Keratoacanthoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.2CRABP2
2MP:001077110.0KRT17, AREG, DSG3, CDKN1A, MMP13, NME1
3MP:000200610.0GZMB, MLH1, CDKN1A, MMP19, NME1, KRT10
4MP:00053779.8CRABP1, CRABP2, KRT10
5MP:00053819.8AREG, MLH1, DSG3, CDKN1A, KRT16, KRT17
6MP:00053979.7DSG3, BAK1, CDKN1A, CD3D, PCNA, NME1
7MP:00053849.6GZMB, MLH1, DSG3, BAK1, CDKN1A, CD3D
8MP:00053879.6GZMB, AREG, DSG3, BAK1, CDKN1A, CD3D
9MP:00107689.4GZMB, CRABP1, CRABP2, MLH1, DSG3, BAK1

Publications for Keratoacanthoma

About this section
Sources:
50PubMed
See all sources

Articles related to Keratoacanthoma:

(show top 50)    (show all 524)
idTitleAuthorsYear
1
Perforating elastic fibers ('elastic fiber trapping') in the differentiation of keratoacanthoma, conventional squamous cell carcinoma, and pseudocarcinomatous epithelial hyperplasia. (24138600)
2013
2
Issues with keratoacanthoma, pseudoepitheliomatous hyperplasia and squamous cell carcinoma within tattoos: a clinical point of view. (19614733)
2010
3
Low rates of somatic p53 mutations in keratoacanthomas. (18829268)
2009
4
Keratoacanthoma of the inferior lip: review and report of case with spontaneous regression. (19466263)
2009
5
Absence of somatic mutations of NEMO in keratoacanthoma. (19404319)
2009
6
Benign fibrous histiocytoma of the eyelid mimicking keratoacanthoma. (17237703)
2007
7
A rapidly growing squamous cell carcinoma or keratoacanthoma or both? (17721662)
2007
8
Beta-catenin and CD44 expression in keratoacanthoma and squamous cell carcinoma of the skin. (17679465)
2007
9
Increased glucose uptake by keratoacanthoma detected by positron emission tomography. (17509063)
2007
10
Association between solitary keratoacanthoma and cigarette smoking: a case-control study. (16638395)
2006
11
Possible key role of granzyme B in keratoacanthoma regression. (16497444)
2006
12
Identification of Muir-Torre syndrome among patients with sebaceous tumors and keratoacanthomas: role of clinical features, microsatellite instability, and immunohistochemistry. (15662714)
2005
13
Lichen planus pemphigoides and multiple keratoacanthomas associated with colon adenocarcinoma. (15270914)
2004
14
Primary cutaneous CD30 anaplastic large cell lymphoma with keratoacanthoma-like pseudocarcinomatous hyperplasia and marked eosinophilia and neutrophilia. (15186435)
2004
15
Multiple, keratoacanthoma-like nodules on a 47-year-old man: a rare presentation of cutaneous lupus erythematosus. (14636190)
2003
16
Self-involution of giant keratoacanthoma on the tip of the nose. (12618621)
2003
17
Keratoacanthoma of the tongue: a diagnostic problem. (12707665)
2003
18
Can we understand keratoacanthoma? (11979078)
2002
19
Keratoacanthoma with perineural invasion: a report of 40 cases. (11488708)
2001
20
The potential role of abnormal E-cadherin and alpha-, beta- and gamma-catenin immunoreactivity in the determination of the biological behaviour of keratoacanthoma. (11703284)
2001
21
Keratoacanthoma developing on a pigmented patch in incontinentia pigmenti. (10828638)
2000
22
Malignant changes in a giant orbital keratoacanthoma developing over 25 years. (10794263)
2000
23
Guess what! Perforating pilomatricoma resembling keratoacanthoma. (10702010)
2000
24
Efficacy of topical photodynamic therapy of a giant keratoacanthoma demonstrated by partial irradiation. (10583189)
1999
25
Multiple familial keratoacanthoma of Witten and Zak - A report of three siblings. (10449942)
1999
26
Desmoglein in multiple self-healing squamous epithelioma of Ferguson-Smith--comparison of staining patterns with actinic keratoacanthoma and squamous cell carcinoma of the skin. (9705163)
1998
27
Generalized eruptive keratoacanthoma of Grzybowski: response to cyclophosphamide. (9146546)
1997
28
Unusual multiple keratoacanthoma in a child successfully treated with 5-fluorouracil. (9301151)
1997
29
Loss of heterozygosity analysis of keratoacanthoma reveals multiple differences from cutaneous squamous cell carcinoma. (8605102)
1996
30
Trisomy 7 in keratoacanthoma and squamous cell carcinoma detected by fluorescence in-situ hybridization. (8835173)
1995
31
Eruptive skin tags and keratoacanthomas in a patient with prolactinoma and colonic polyposis. (8075462)
1994
32
p53 oncoprotein expression and proliferation index in keratoacanthoma and squamous cell carcinoma. (8304756)
1994
33
The regressing keratoacanthoma. (8045528)
1994
34
Keratoacanthoma: a deficient squamous cell carcinoma? Study of bcl-2 expression. (7699118)
1994
35
Giant keratoacanthoma of the plantar foot: a report of two cases. (8318965)
1993
36
Dowling-Degos disease, hidradenitis suppurativa, and multiple keratoacanthomas. A disorder that may be caused by a single underlying defect in pilosebaceous epithelial proliferation. (2050858)
1991
37
Transforming growth factor alpha expression helps to distinguish keratoacanthomas from squamous cell carcinomas. (1863074)
1991
38
Suspected keratoacanthoma--a wolf in sheep's clothing? (2235857)
1990
39
Subungual keratoacanthoma in the hand. (2723363)
1989
40
Large periocular keratoacanthoma: the case for definitive treatment. (3774277)
1986
41
The use of podophyllin in the treatment of keratoacanthoma. (6629612)
1983
42
Keratoacanthoma arising in a linear epidermal nevus. (7082032)
1982
43
Subungual keratoacanthoma. (7258561)
1980
44
Metastasizing keratoacanthoma? (419204)
1979
45
Solitary intraoral keratoacanthoma. Report of a case. (282567)
1979
46
Giant keratoacanthoma: a problem in diagnosis and management. (1223153)
1975
47
Keratoacanthoma in a smallpox vaccination site. (4852612)
1974
48
Solitary intraoral keratoacanthoma. (4524889)
1974
49
Squamous carcinoma of the eyelid simulating keratoacanthoma: report of a case. (4533886)
1974
50
Keratoacanthoma of the lower lip: report of cases. (4503605)
1972

Genetic Variations for Keratoacanthoma

About this section

Expression for genes affiliated with Keratoacanthoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Keratoacanthoma

Search GEO for disease gene expression data for Keratoacanthoma.

Pathways for genes affiliated with Keratoacanthoma

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 12EMD Millipore, 4Cell Signaling Technology
See all sources

Pathways related to Keratoacanthoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3MSH2, MLH1
2
Hide members
10.2MMP19, MMP10, MMP13
3
Cell adhesion ECM remodeling
Hide members
10.2MMP19, MMP10, MMP13
4
Hide members
10.2MMP13, MMP10, MMP19
5
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
10.2MLH1, PCNA, MSH2
6
Hide members
10.1MLH1, CDKN1A, PCNA, MSH2
710.0MSH2, PCNA, CDKN1A, BAK1, MLH1
8
Hide members
10.0MLH1, MKI67, CDKN1A, PCNA, MSH2
9
Hide members
10.0GZMB, DSG3, BAK1, CDKN1A, PCNA
10
Hide members
9.9MMP19, MMP10, MMP13, CD3D, CDKN1A, AREG

Compounds for genes affiliated with Keratoacanthoma

About this section
Sources:
44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB
See all sources

Compounds related to Keratoacanthoma according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8IVL
2cycloheximide4410.6CRABP2
3etoposide44 49 59 1113.6BAK1, MLH1, GZMB
4dithranol4410.5IVL, KRT10, KRT16
5chi 24410.5NME1, MKI67, MLH1
6calcipotriol44 59 28 1113.5KRT10, KRT16, IVL
7temozolomide44 1111.5MLH1, CDKN1A, MSH2, PCNA
8gm 60015910.5MMP13, MMP19, MMP10
9mnng4410.5MSH2, PCNA, MLH1
10acitretin44 1111.5KRT17, IVL, CRABP1
11uk 3833675910.5MMP13, MMP10, MMP19
12gi 254023x5910.5MMP13, MMP10, MMP19
13isotretinoin44 1111.5KRT10, MKI67, CRABP1, KRT16
14sodium dodecylsulfate4410.4KRT17, KRT16, IVL, CRABP2
15dutp4410.4PCNA, KRT10, MKI67, BAK1
16o6-methylguanine4410.4MSH2, MLH1, PCNA
17hematoxylin4410.4MKI67, KRT10, PCNA, IVL
18irinotecan44 49 1112.4CDKN1A, MLH1, BAK1, MKI67
19celecoxib44 59 28 49 11 2415.4MKI67, BAK1, CDKN1A, PCNA
20biotin44 11 2412.4MSH2, MLH1, MKI67, PCNA, NME1
21thymidylate4410.4MKI67, MLH1, CDKN1A, PCNA, MSH2
22paclitaxel44 49 1112.3MLH1, BAK1, CDKN1A
23steroid4410.3CRABP2, MKI67, NME1, KRT16, KRT10, GZMB
24p0024410.3MLH1, MKI67, MMP13, NME1
25marimastat44 59 1112.3MMP10, MMP19, MMP13
26gf 109203x44 5911.3IVL, CDKN1A, KRT10, MMP13
27bromodeoxyuridine4410.3MLH1, IVL, MKI67, CDKN1A, PCNA, KRT10
28dexamethasone44 49 28 1113.3NME1, PCNA, BAK1, MMP13, AREG, GZMB
29fatty acid4410.3CRABP2, MLH1, IVL, NME1, KRT10, CRABP1
30calcitriol44 59 11 2413.2KRT16, BAK1, KRT10, NME1, CDKN1A, AREG
3112-o-tetradecanoylphorbol 13-acetate4410.2MMP10, GZMB, AREG, MMP13, CDKN1A, BAK1
32agarose4410.1MLH1, CDKN1A, GZMB, MMP13
33progesterone44 59 28 11 2414.1MLH1, MKI67, CDKN1A, PCNA, KRT10, AREG
34crcs4410.1MSH2, MLH1, NME1
355fluorouracil4410.1MKI67, MSH2, BAK1, IVL, CDKN1A, PCNA
36thymidine44 2411.1PCNA, MMP13, MKI67, IVL, MLH1, AREG
37proline4410.1CRABP1, MSH2, CRABP2, MLH1, MKI67, KRT16
38camptothecin44 59 1112.1PCNA, BAK1, CDKN1A, MLH1
39oxygen44 2411.0BAK1, MKI67, CDKN1A, MMP13, IVL
40oligonucleotide4410.0GZMB, IVL, CDKN1A, PCNA, MMP10, NME1
41arginine4410.0MKI67, MLH1, CRABP2, PCNA, KRT10, CRABP1
42cisplatin44 49 59 1113.0GZMB, MSH2, NME1, PCNA, CDKN1A, MLH1
43retinoid4410.0IVL, CRABP2, MMP13, CDKN1A, KRT16, KRT10
44serine4410.0NME1, MMP10, MMP13, MKI67, DSG3, KRT17
45vegf449.9IVL, PCNA, MLH1, AREG, GZMB, MKI67
46calcium44 49 11 2412.8IVL, AREG, KRT10, DSG3, CRABP1, GZMB
47tyrosine449.8KRT17, NME1, MMP13, CDKN1A, MKI67, BAK1
48paraffin449.7MSH2, MMP13, NME1, KRT16, KRT10, KRT17
49doxorubicin44 49 1111.7BAK1, CDKN1A, MLH1, MKI67, MSH2
50retinoic acid44 2410.4MKI67, BAK1, MLH1, CRABP2, CRABP1, AREG

GO Terms for genes affiliated with Keratoacanthoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Keratoacanthoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.2KRT17, KRT10, KRT16
2PCNA-p21 complexGO:07055710.0PCNA, CDKN1A

Biological processes related to Keratoacanthoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:00629810.4MSH2, PCNA, MLH1
2intrinsic apoptotic signaling pathwayGO:09719310.4GZMB, BAK1, CDKN1A
3organ regenerationGO:03110010.4CDKN1A, MKI67, BAK1
4response to UV-BGO:01022410.4MSH2, IVL
5negative regulation of gene expressionGO:01062910.3NME1, CDKN1A, BAK1
6collagen catabolic processGO:03057410.3MMP13, MMP10, MMP19
7isotype switchingGO:04519010.3MSH2, MLH1
8epidermis developmentGO:00854410.2KRT17, KRT16, CRABP2
9extracellular matrix disassemblyGO:02261710.1MMP13, MMP10, MMP19
10somatic hypermutation of immunoglobulin genesGO:01644610.0MSH2, MLH1

Molecular functions related to Keratoacanthoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1guanine/thymine mispair bindingGO:03213710.5MSH2, MLH1
2dinucleotide insertion or deletion bindingGO:03213910.4MSH2, PCNA
3MutLalpha complex bindingGO:03240510.4MSH2, PCNA
4retinoid bindingGO:00550110.3CRABP2, CRABP1
5single-stranded DNA bindingGO:00369710.2MLH1, NME1, MSH2
6metalloendopeptidase activityGO:00422210.2MMP19, MMP10, MMP13
7retinal bindingGO:01691810.1CRABP2, CRABP1
8retinol bindingGO:0198419.9CRABP2, CRABP1

Products for genes affiliated with Keratoacanthoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Keratoacanthoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet