MCID: KRT006
MIFTS: 60

Keratoconjunctivitis malady

Infectious diseases, Eye diseases categories

Summaries for Keratoconjunctivitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Keratoconjunctivitis is inflammation (\"-itis\") of the cornea and conjunctiva. more...

MalaCards: Keratoconjunctivitis, also known as certain types of keratoconjunctivitis, is related to keratoconjunctivitis sicca and conjunctivitis. An important gene associated with Keratoconjunctivitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Selected targets of GCR-alpha and OX40 Pathway. The drugs lodoxamide tromethamine and lodoxamide and the compounds pge2 and hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related mouse phenotypes are homeostasis/metabolism and respiratory system.

Aliases & Classifications for Keratoconjunctivitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 27ICD9CM, 25ICD10
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Related Diseases for Keratoconjunctivitis

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17GeneCards, 18GeneDecks
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Diseases related to Keratoconjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 264)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis sicca31.6LTF, HSPG2
2conjunctivitis30.7RNASE3, IGHE
3keratitis30.6CXCL9
4corneal ulcer30.5NGF, PRG2, CCL11
5vernal keratoconjunctivitis30.5VCAM1, CMA1, IL4, IL5, IL3, IL13
6allergic conjunctivitis30.4IL4, IL5, IL13, RNASE3, IGHE, CCL11
7sjogren's syndrome30.4CXCL9, CXCR3, LTF, HSPG2
8dermatitis30.4VCAM1, CMA1, IL4, IL5, IL13, CXCL9
9arthritis30.3MMP1, MMP3, IL4, IL13, CXCL9, CXCR3
10rheumatoid arthritis30.3VCAM1, MMP1, MMP3, IL4, IL13, CXCL9
11atopic dermatitis30.2VCAM1, CMA1, IL4, IL5, IL13, CXCL9
12eye disease30.2NGF
13uveitis30.2IL4, CXCL9, CXCR3, CCL11
14encephalitis30.2VCAM1, CXCL9, CCL5
15giant papillary conjunctivitis30.1IL5, RNASE3, LTF, CCL11
16graft versus host disease30.1IL4, IL3, IL13, CCL5
17dry eye syndrome30.1LTF, HSPG2
18erythema multiforme29.9HSPG2
19lichen planus29.9CXCL9, CXCR3
20esophagitis29.9IL5, IL13, PRG2, CCL11
21herpes simplex29.9CCL5
22glaucoma29.9MMP1
23sarcoidosis29.9IL13, CXCL9, CXCR3, CCL5, CCL11
24influenza29.9CXCL9, CXCR3, LTF, CCL5, CCL11
25eosinophilia29.9VCAM1, IL4, IL5, IL3, IL13, RNASE3
26asthma29.9IL13, CCL11
27peritonitis29.7CMA1
28stevens-johnson syndrome29.7HSPG2
29hypertension29.7VCAM1
30otitis media29.7RNASE3, LTF, IGHE, CCL11
31tuberculosis29.7IL4, CXCL9, CXCR3
32diabetes mellitus29.7VCAM1, MMP3, NGF
33common variable immune deficiency29.7IL4
34allergic rhinitis29.7IL4, IL5, IL13, RNASE3, IGHE, CCL11
35obesity29.7MMP3, CCL5, CCL11
36pneumonia29.7IL5, IL13, CCL5, CCL11, CCL22, HSPG2
37rhinitis29.7VCAM1, CMA1, IL4, IL5, IL13, RNASE3
38allergic asthma29.7VCAM1, CMA1, IL4, IL5, IL3, IL13
39diabetic retinopathy29.7VCAM1
40conjunctivochalasis29.7MMP1, MMP3
41vernal conjunctivitis10.4
42keratoconus10.3
43superior limbic keratoconjunctivitis10.3
44corneal disease10.1
45shipyard eye10.1
46st. louis encephalitis10.1
47dacryoadenitis10.1
48papillary conjunctivitis10.1
49atopic keratoconjunctivitis10.1
50rosacea10.1

Graphical network of the top 20 diseases related to Keratoconjunctivitis:



Diseases related to keratoconjunctivitis

Clinical Features for Keratoconjunctivitis

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Drugs & Therapeutics for Keratoconjunctivitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Keratoconjunctivitis

Drug clinical trials:

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Search CenterWatch for Keratoconjunctivitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Keratoconjunctivitis

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Anatomical Context for Keratoconjunctivitis

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32MalaCards
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MalaCards organs/tissues related to Keratoconjunctivitis:

32
Eye, Testes, T cells, Bone, Salivary gland, Bone marrow, Thyroid, B cells

Animal Models for Keratoconjunctivitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Keratoconjunctivitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.1IGHE, LTF, NGF, CXCR3, IL13, IL3
2MP:000538810.0CCL24, CCL11, PRG2, CXCR3
3MP:000539710.0HSPG2, CCL24, CCL11, CCL5, PRG2, IGHE
4MP:00053879.9VCAM1, HSPG2, CCL24, CCL11, CCL5, PRG2

Publications for Keratoconjunctivitis

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50PubMed
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Articles related to Keratoconjunctivitis:

(show top 50)    (show all 944)
idTitleAuthorsYear
1
Vernal keratoconjunctivitis: an update. (23038763)
2013
2
An Essential Role for Dendritic Cells in Vernal Keratoconjunctivitis: Analysis by Laser Scanning Confocal Microscopy. (24372712)
2013
3
Atopic keratoconjunctivitis: A review. (24342754)
2013
4
Management, clinical outcomes, and complications of shield ulcers in vernal keratoconjunctivitis. (23218707)
2013
5
Punctal plugs versus artificial tears for treating primary SjAPgren's syndrome with keratoconjunctivitis SICCA: a comparative observation of their effects on visual function. (23649850)
2013
6
Identification of human tear fluid biomarkers in vernal keratoconjunctivitis using iTRAQ quantitative proteomics. (24329893)
2013
7
Occurrence, quantification, and genotyping of Mycoplasma conjunctivae in wild Caprinae with and without infectious keratoconjunctivitis. (22740528)
2012
8
Meibomitis-related keratoconjunctivitis: implications and clinical significance of meibomian gland inflammation. (23038034)
2012
9
Cyclosporine a 0.05% eye drops for the treatment of subepithelial infiltrates after epidemic keratoconjunctivitis. (22900547)
2012
10
Eosinophilic keratoconjunctivitis in two rabbits. (22051177)
2012
11
Genetic parameters of infectious bovine keratoconjunctivitis and its relationship with weight and parasite infestations in Australian tropical Bos taurus cattle. (22839739)
2012
12
Vernal keratoconjunctivitis in school children in Rwanda and its association with socio-economic status: a population-based survey. (21976577)
2011
13
Profile of vernal keratoconjunctivitis in Nepal: a hospital based study. (22364089)
2011
14
Epidemiological and virological features of epidemic keratoconjunctivitis due to new human adenovirus type 54 in Japan. (20530657)
2011
15
The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis. (21151139)
2011
16
Anti-adenoviral effect of interferon-I^ and interferon-I^ in serotypes that cause acute keratoconjunctivitis. (21070541)
2011
17
A clinical study to assess the efficacy of Triyushnadi Anjana in Kaphaja Abhishyanda with special reference to vernal keratoconjunctivitis. (22048541)
2010
18
The epithelium takes center stage in allergic keratoconjunctivitis. (20935541)
2010
19
Basophils in the giant papillae of chronic allergic keratoconjunctivitis. (19828516)
2010
20
The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca. (19668545)
2009
21
Analysis of the complete genome sequence of epidemic keratoconjunctivitis-related human adenovirus type 8, 19, 37 and a novel serotype. (19264666)
2009
22
Cytokines, matrix metalloproteases, angiogenic and growth factors in tears of normal subjects and vernal keratoconjunctivitis patients. (19220217)
2009
23
Unilateral vernal keratoconjunctivitis: a case report. (18050126)
2007
24
Eyelash length in children with vernal keratoconjunctivitis: effect of treatment with cyclosporine eye drops. (17880772)
2007
25
Immunopathogenesis of conjunctival remodelling in vernal keratoconjunctivitis. (15746957)
2006
26
Eosinophilic keratitis and keratoconjunctivitis in a 7-year-old domestic shorthaired cat. (16363332)
2005
27
Allergic chronic inflammation of the ocular surface in vernal keratoconjunctivitis. (14501439)
2003
28
Oral pilocarpine for the treatment of keratoconjunctivitis sicca with central corneal irregularity. (14670440)
2003
29
Montelukast, a leukotriene receptor antagonist, in vernal keratoconjunctivitis associated with asthma. (12742837)
2003
30
Toxic eosinophil granule protein deposition in corneal ulcerations and scars associated with atopic keratoconjunctivitis. (12470748)
2002
31
Perilimbal conjunctival pigmentation in vernal keratoconjunctivitis: a new sign. (11973399)
2002
32
Supratarsal injection of corticosteroids in the treatment of refractory vernal keratoconjunctivitis. (12930116)
2001
33
Microvascular submandibular gland transfer for severe cases of keratoconjunctivitis sicca. (10987460)
2000
34
The role of apoptosis in the pathogenesis of canine keratoconjunctivitis sicca: the effect of topical Cyclosporin A therapy. (9820947)
1998
35
Incidence of ocular complications in rheumatoid arthritis and the relation of keratoconjunctivitis sicca with its systemic activity. (9137326)
1997
36
Microorganisms isolated from the corneal surface before and during topical cyclosporine treatment in dogs with keratoconjunctivitis sicca. (7574155)
1995
37
Keratoconjunctivitis sicca in female patients infected with human immunodeficiency virus. (8149575)
1994
38
Acute dacryocystitis after punctal occlusion of keratoconjunctivitis sicca. (2039051)
1991
39
Vernal keratoconjunctivitis and trachoma. (3220668)
1988
40
Keratoconjunctivitis sicca. (3393103)
1988
41
Treatment of superior limbic keratoconjunctivitis with topical cromolyn sodium. (3113315)
1987
42
Treatment of keratoconjunctivitis sicca with Lacrisert. (3296154)
1986
43
An in vivo study of the corneal surface in keratoconjunctivitis sicca. (2412322)
1985
44
The fine structure of nuclear changes in superior limbic keratoconjunctivitis. (621134)
1978
45
Keratoconjunctivitis sicca in dogs. (960385)
1976
46
Is the lacrimal gland dispensable? Keratoconjunctivitis sicca after lacrimal gland removal. (1119971)
1975
47
Tear volume in normal eyes and keratoconjunctivitis sicca. (4548323)
1974
48
Some problems concerning keratoconjunctivitis sicca and the sicca-syndrome. (14837717)
1951
49
Keratoconjunctivitis sicca; a sequela to purulent erythema exudativum multiforme (Stevens-Johnson's disease). (20997654)
1946
50
Notes on Keratoconjunctivitis Sicca. (16693337)
1943

Genetic Variations for Keratoconjunctivitis

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Expression for genes affiliated with Keratoconjunctivitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratoconjunctivitis

Search GEO for disease gene expression data for Keratoconjunctivitis.

Pathways for genes affiliated with Keratoconjunctivitis

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12EMD Millipore, 51QIAGEN, 52R&D Systems, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome
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Pathways related to Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IL4, IL5, CCL11
210.4IL4, IL5, IL13
310.4IL13, IL5, IL4
410.4IL4, IL5, IL3
5
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10.4IL3, IL5, IL4
610.4IL13, IL3, IL5, IL4
710.4IL13, IL3, IL5, IL4
810.4CCL11, CXCR3, CXCL9
9
Cell adhesion ECM remodeling
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10.4CMA1, MMP1, MMP3
10
Cell adhesion Cell-matrix glycoconjugates
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10.4MMP1, MMP3, CCL5
1110.4IL13, IL5, IL4, MMP1
1210.4CCL11, IGHE, IL5, IL4
13
Hide members
10.4MMP1, MMP3, HSPG2
1410.3VCAM1, IL4, IL3, CCL5
15
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10.3HSPG2, MMP3, MMP1, CMA1
16
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10.3CCL11, IGHE, IL13, IL3, IL5, IL4
1710.3CCL22, CCL11, CCL5, CXCR3, CXCL9
18
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10.3CCL11, PRG2, RNASE3, IL13, IL3, IL5
19
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10.3CCL22, CCL24, CCL11, CCL5, CXCR3, CXCL9
20
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10.3HSPG2, CCL22, CCL24, PRG2, CXCR3, IL5
21
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10.2CCL22, CCL24, CCL11, CCL5, IL13, IL3
22
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10.2CCL22, CCL24, CCL11, CXCR3, CXCL9, IL13
23
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10.2IL5, IL3, IL13, CXCL9, CXCR3, CCL5
24
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10.2CCL22, IL4, IL5, IL3, IL13, CXCL9
25
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10.1HSPG2, CCL22, CCL11, CCL5, NGF, CXCR3
26
Hide members
10.1VCAM1, HSPG2, CCL22, CCL24, CCL11, CCL5

Compounds for genes affiliated with Keratoconjunctivitis

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44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Keratoconjunctivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 211)
idCompoundScoreTop Affiliating Genes
1pge24410.9CCL11
2hydrocortisone44 2 59 1113.8IGHE, LTF, MMP1
3rantes4410.8CCL11, RNASE3, CXCR3, IL3, IL4
4indomethacin44 59 28 1113.7HSPG2, PRG2, LTF, NGF, IL5
5salmeterol44 49 28 1113.7IL4, CCL11, IL5, IL13, RNASE3, CCL5
6fluticasone propionate44 49 59 1113.7CCL11, CCL5, VCAM1, IL4, IL5, IL13
7endotoxin4410.7LTF, RNASE3, VCAM1, CXCR3
8montelukast44 49 28 1113.7IL4, IL5, IL13, RNASE3, IGHE, CCL11
9allergens4410.6IL4, CMA1, PRG2, CCL11, IGHE, RNASE3
10leukotriene b444 59 2412.6IL13, RNASE3, LTF, CCL5, CCL11, CCL22
11ltc44410.6CCL11, IL13, RNASE3, IL3, PRG2, IL5
12il 104410.6IL4, IL13, CXCL9, IL3, IL5, CCL5
13cycloheximide4410.6HSPG2
14sodium cromoglycate4410.6VCAM1, CCL11, IGHE, RNASE3, IL5
15cyclosporin a44 28 5912.6CCL22, CCL11, CCL5, IGHE, LTF, NGF
16prednisolone44 28 1112.6VCAM1, CCL11, IGHE, NGF, RNASE3, IL13
17budesonide44 49 1112.6IL13, RNASE3, LTF, IGHE, CCL5, CCL11
18dexamethasone44 49 28 1113.6LTF, RNASE3, IL13, IL3, IL5, IGHE
19capsaicin44 2811.6IGHE, HSPG2, LTF, RNASE3, IL5, CMA1
20ccl344 2811.6CCL11, CXCL9, CXCR3, CCL5, IL13, CCL22
21fmlp4410.6LTF, CCL11, PRG2, HSPG2, RNASE3, VCAM1
22methacholine44 1111.6CCL5, PRG2, IGHE, LTF, RNASE3, IL13
23groalpha4410.6CXCL9, IL13, VCAM1, CXCR3, CCL5, CCL11
24tarc4410.6IL4, IL5, IL13, CXCL9, CXCR3, IGHE
25aspirin44 49 28 2413.6HSPG2, CCL22, IL4, MMP1, IL13, RNASE3
26herbimycin a44 5911.6VCAM1, MMP1, HSPG2, IL4, IL3, NGF
27sb 20358044 5911.6IL5, IL13, IL4, NGF, CCL5, MMP3
28nedocromil sodium4410.6RNASE3, IGHE, IL4, IL5, IL3
29salbutamol44 49 28 11 2414.6IGHE, VCAM1, IL5, IL13, RNASE3, CCL11
30ly2940024410.6IL4, IL5, IL3, IL13, CXCR3, NGF
31n acetylcysteine4410.5CCL5, LTF, RNASE3, IL4, MMP3, VCAM1
32tacrolimus44 49 1112.5IL13, IL3, IL4, IL5, CCL22, CCL11
33heparin44 28 11 2413.5LTF, RNASE3, CXCR3, MMP3, CMA1, VCAM1
34adenylate4410.5VCAM1, IL13, IL3, IL4, RNASE3, NGF
35genistein44 28 59 2 11 2415.5MMP3, HSPG2, CCL11, CCL5, NGF, IL5
36pranlukast44 28 1112.5CCL5, CCL11, RNASE3, IL5, IL4
37pgd24410.4IL5, CCL11, PRG2, IGHE, RNASE3, IL13
38creatinine4410.4NGF, RNASE3, IGHE, CXCR3, CXCL9, IL3
39retinoic acid44 2411.4CCL11, CCL5, PRG2, IGHE, LTF, NGF
40pd 98,0594410.4HSPG2, CCL5, VCAM1, IL3, NGF, CXCR3
41vegf4410.4HSPG2, CCL11, CCL5, VCAM1, IGHE, LTF
42cysteine4410.4IL5, PRG2, LTF, IL13, IL3, CCL5
43actinomycin d4410.3IL4, IGHE, IL3, IL13, LTF, PRG2
44azelastine44 1111.3IL3, IL5, RNASE3, IGHE, IL4
45pertussis4410.3HSPG2, CCL11, CCL5, IGHE, LTF, CCL22
46tyrosine4410.3PRG2, CXCL9, CXCR3, RNASE3, NGF, IL3
47poly(i-c)4410.3VCAM1, IL4, IL5, IL3, CCL5, CCL11
48histamine44 28 2412.3HSPG2, IL3, IL5, IL4, MMP3, CMA1
49praziquantel44 1111.2RNASE3, IL13, IGHE, IL5, IL4
50n-formylmethionyl-leucylphenylalanine4410.0IL5, HSPG2, CCL11, LTF, IL3, RNASE3

GO Terms for genes affiliated with Keratoconjunctivitis

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16Gene Ontology
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Cellular components related to Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.3VCAM1, IL4, IL13, CXCL9, CXCR3
2extracellular regionGO:0055769.8CMA1, HSPG2, CCL22, CCL11, CCL5, PRG2
3extracellular spaceGO:0056159.7HSPG2, CCL22, CCL24, CCL11, CCL5, NGF

Biological processes related to Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:03089010.6IL13, IL5, IL4
2eosinophil chemotaxisGO:04824510.6CCL5, CCL11, CCL24
3regulation of proton transportGO:01015510.6IL4, IL13
4positive regulation of T cell proliferationGO:04210210.6VCAM1, IL4, CCL5
5chronic inflammatory responseGO:00254410.5CCL11, VCAM1
6cell-cell signalingGO:00726710.5CCL22, CCL24, CCL5, CXCL9, IL13, IL3
7chemotaxisGO:00693510.5CCL22, CCL24, CCL11, CCL5, CXCR3, CXCL9
8positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.5IL4, IL5, NGF
9inflammatory responseGO:00695410.5CCL22, CCL24, CCL11, CCL5, NGF, CXCR3
10positive regulation of JAK-STAT cascadeGO:04642710.4IL5, CCL5
11immune responseGO:00695510.4IL4, CCL22, CCL24, CCL11, PRG2, IGHE
12extracellular matrix disassemblyGO:02261710.4CMA1, MMP1, MMP3
13positive regulation of angiogenesisGO:04576610.3CCL24, CCL11, CMA1
14extracellular matrix organizationGO:03019810.0CMA1, MMP1, MMP3, HSPG2

Molecular functions related to Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00808310.4IL4, IL5, IL3, NGF
2chemokine activityGO:00800910.2CXCL9, CCL5, CCL11, CCL24, CCL22
3cytokine activityGO:00512510.0CXCL9, IL13, IL3, IL5, IL4

Products for genes affiliated with Keratoconjunctivitis

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  • Antibodies
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Sources for Keratoconjunctivitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet