MCID: KRT006
MIFTS: 57

Keratoconjunctivitis malady

Infectious diseases, Eye diseases categories
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Summaries for Keratoconjunctivitis

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Wikipedia:65 Keratoconjunctivitis is inflammation (\"-itis\") of the cornea and conjunctiva. more...

MalaCards based summary: Keratoconjunctivitis, also known as certain types of keratoconjunctivitis, is related to conjunctivitis and corneal ulcer. An important gene associated with Keratoconjunctivitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Inflammatory Response Pathway and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions. The drugs lodoxamide tromethamine and lodoxamide and the compounds unicap and omalizumab have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related mouse phenotypes are respiratory system and immune system.

Aliases & Classifications for Keratoconjunctivitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 39NCIt, 34MeSH, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Keratoconjunctivitis, Aliases & Descriptions:

Name: Keratoconjunctivitis 8 10 44 62
 
Certain Types of Keratoconjunctivitis 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:9368
NCIt39 C34744
MeSH34 D007637
ICD9CM27 370.40
ICD1025 B30.0, H16.2

Related Diseases for Keratoconjunctivitis

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Diseases related to Keratoconjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 161)
idRelated DiseaseScoreTop Affiliating Genes
1conjunctivitis31.5RNASE3
2corneal ulcer30.9CCL11, NGF
3uveitis30.5IL4, CCL11
4giant papillary conjunctivitis30.5CCL11, RNASE3, IL5
5asthma30.5CCL11, IL13
6esophagitis30.3IL13, IL5, CCL11
7allergic conjunctivitis30.3RNASE3, CCL11, IL4, IL5, IL13
8rheumatoid arthritis30.3IL4, IL13, CCL11, RNASE3
9graft versus host disease30.2IL4, IL13, IL3
10otitis media30.2CCL11, RNASE3
11vernal keratoconjunctivitis30.2NGF, RNASE3, IL13, IL3, IL5, IL4
12colitis30.1IL13, NGF, IL4
13pneumonia30.0CCL11, IL5, IL13, CCL22
14dermatitis29.6CCL22, CCL11, CMA1, IL4, IL5, IL13
15atopic dermatitis29.6CCL22, IL4, NGF, RNASE3, IL13, CCL11
16allergic rhinitis29.3IL5, NGF, RNASE3, IL4, CCL11, IL13
17eosinophilia29.1CCL11, IL13, IL3, IL5, IL4, NGF
18atopy29.1RNASE3, CMA1, CCL22, IL4, IL5, IL13
19rhinitis29.1CCL11, CMA1, IL13, IL5, RNASE3, IL4
20allergic asthma28.3IL13, IL3, IL5, IL4, CCL11, CMA1
21keratoconjunctivitis sicca11.1
22atopic keratoconjunctivitis10.8
23superior limbic keratoconjunctivitis10.8
24folliculitis10.5CCL11
25keratitis10.5
26paragonimiasis10.5IL5
27strongyloidiasis10.5IL5
28keratoconus10.4
29blindness10.4
30eosinophilic esophagitis10.4IL5, CCL11
31cystitis10.4NGF
32urticaria10.4RNASE3
33eosinophilic gastroenteritis10.3IL5, CCL11
34kimura disease10.3RNASE3, IL5
35egg allergy10.3IL5, IL4
36allergic bronchopulmonary aspergillosis10.3IL4, IL5
37sjogren's syndrome10.3
38onchocerciasis10.3IL5, RNASE3
39churg-strauss syndrome10.3IL5, RNASE3
40autosomal dominant hyper ige syndrome10.3IL4, RNASE3
41common cold10.3CCL11, RNASE3
42arthritis10.3
43omenn syndrome10.3IL5, IL4
44filariasis10.3IL13, IL5
45sezary's disease10.3IL5, IL4
46shipyard eye10.2
47angioedema10.2RNASE3, IL5
48hypereosinophilic syndrome10.2IL5, IL3
49sinusitis10.2RNASE3, IL5, CCL11
50chronic eosinophilic pneumonia10.2IL5, CCL11, RNASE3

Graphical network of the top 20 diseases related to Keratoconjunctivitis:



Diseases related to keratoconjunctivitis

Symptoms for Keratoconjunctivitis

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Drugs & Therapeutics for Keratoconjunctivitis

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Drug clinical trials:

Search ClinicalTrials for Keratoconjunctivitis

Search NIH Clinical Center for Keratoconjunctivitis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Keratoconjunctivitis

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Anatomical Context for Keratoconjunctivitis

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MalaCards organs/tissues related to Keratoconjunctivitis:

32
Eye, Testes, T cells, Bone, Salivary gland, Bone marrow, Thyroid, B cells, Neutrophil

Animal Models for Keratoconjunctivitis or affiliated genes

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MGI Mouse Phenotypes related to Keratoconjunctivitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.3IL13, IL3, IL5, IL4, CCL11
2MP:00053877.5CMA1, CCL11, IL5, IL3, IL13, IL4
3MP:00053977.2IL3, IL5, IL4, CCL11, IL13, CMA1

Publications for Keratoconjunctivitis

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Articles related to Keratoconjunctivitis:

(show top 50)    (show all 961)
idTitleAuthorsYear
1
Evaluation of the impact of persistent subepithelial corneal infiltrations on the visual performance and corneal optical quality after epidemic keratoconjunctivitis. (25043311)
2014
2
The Role of Chlamydia Pneumoniae in the Etiology Keratoconjunctivitis Sicca (KCS). (25395268)
2014
3
Increased incidence of thyroid dysfunction and autoimmunity in patients with vernal keratoconjunctivitis. (25140177)
2014
4
Epidemic adenoviral keratoconjunctivitis complicated by massive bilateral lower eyelid cysts. (24398504)
2014
5
Surgical resection and amniotic membrane transplantation for treatment of refractory giant papillae in vernal keratoconjunctivitis. (23086371)
2013
6
Superior limbic keratoconjunctivitis causing chronic ocular irritation in a child. (23791418)
2013
7
Management of vernal keratoconjunctivitis. (25135808)
2013
8
Surgical treatment of 32 cases of long-term atopic keratoconjunctivitis using the amniotic membrane. (23949491)
2013
9
Corneal sequestrum in a dog with chronic unilateral keratoconjunctivitis sicca. (24299547)
2013
10
Topical calcineurin inhibitors in the treatment of steroid-dependent atopic keratoconjunctivitis. (22378107)
2012
11
Evaluation of cytokines as adjuvants of infectious bovine keratoconjunctivitis vaccines. (22264735)
2012
12
Occurrence, quantification, and genotyping of Mycoplasma conjunctivae in wild Caprinae with and without infectious keratoconjunctivitis. (22740528)
2012
13
Superior limbic keratoconjunctivitis causing chronic ocular irritation in a child. (23158547)
2012
14
Acute haemorrhagic conjunctivitis epidemics and outbreaks of Paederus spp. keratoconjunctivitis ('Nairobi red eyes') and dermatitis. (21920128)
2011
15
Ocular surface disease: a case of vernal keratoconjunctivitis. (20971677)
2011
16
Association of toll-like receptor four single nucleotide polymorphisms with incidence of infectious bovine keratoconjunctivitis (IBK) in cattle. (20938658)
2011
17
Systemic cyclosporin A in severe atopic keratoconjunctivitis. (20491051)
2010
18
Possible unilateral ultraviolet keratoconjunctivitis during an expedition-length desert race. (20591383)
2010
19
Conjunctival impression cytology for the diagnosis, follow-up, and treatment in a patient with severe keratoconjunctivitis caused by alkali injury. (19574901)
2009
20
Keratoconjunctivitis associated with Toxoplasma gondii in a dog. (19152600)
2009
21
Nucleotide sequence variation in the hexon gene of human adenovirus type 8 and 37 strains from epidemic keratoconjunctivitis patients in Japan. (19458172)
2009
22
Corneal in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. (18584874)
2008
23
Vaccine against infectious bovine keratoconjunctivitis: a new approach to optimize the production of highly piliated Moraxella bovis cells. (18852003)
2008
24
Natural killer cells in vernal keratoconjunctivitis. (17893656)
2007
25
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)
2006
26
Topical cyclosporine A in severe steroid-dependent childhood phlyctenular keratoconjunctivitis. (16386977)
2006
27
Effect of cyclosporin A eye drop on keratoconjunctivitis sicca and its mechanism. (16696343)
2005
28
Prevention of naturally occurring infectious bovine keratoconjunctivitis with a recombinant Moraxella bovis cytotoxin-ISCOM matrix adjuvanted vaccine. (15530703)
2004
29
Rapid and sensitive diagnosis of adenoviral keratoconjunctivitis by loop-mediated isothermal amplification (LAMP) method. (15590466)
2004
30
Tumor necrosis factor-alpha (TNF-alpha) in seasonal allergic conjunctivitis and vernal keratoconjunctivitis. (14552593)
2003
31
The T-lymphocyte chemoattractant Mig is highly expressed in vernal keratoconjunctivitis. (14597036)
2003
32
Videokeratography findings in children with vernal keratoconjunctivitis versus those of healthy children. (12414408)
2002
33
Active matrix metalloproteinases in the tear fluid of individuals with vernal keratoconjunctivitis. (12209100)
2002
34
Histologic characteristics and local cellular immunity of the gland of the third eyelid after topical ophthalmic administration of 2% cyclosporine for treatment of dogs with keratoconjunctivitis sicca. (12013470)
2002
35
Nedocromil sodium eye drops are more effective than sodium cromoglycate eye drops for the long-term management of vernal keratoconjunctivitis. (10202368)
1999
36
Vernal keratoconjunctivitis in a Stockholm ophthalmic centre--epidemiological, functional, and immunologic investigations. (10551301)
1999
37
Estrogen therapy in keratoconjunctivitis sicca. (9635003)
1998
38
The association of conjunctival snake-like chromatin with keratoconjunctivitis SICCA. (9891892)
1998
39
Lodoxamide in vernal keratoconjunctivitis. (8740338)
1996
40
Increased serum levels of eosinophil cationic protein and eosinophil-derived neurotoxin (protein X) in vernal keratoconjunctivitis. (7800361)
1994
41
Atopic keratoconjunctivitis. (22823113)
1994
42
Efficacy and safety of lodoxamide 0.1% vs cromolyn sodium 4% in patients with vernal keratoconjunctivitis. (1598953)
1992
43
Keratoconjunctivitis sicca and diabetes mellitus in a dog. (1639704)
1992
44
Unpreserved carboxymethylcellulose artificial tears evaluated in patients with keratoconjunctivitis sicca. (1424648)
1992
45
Acute dacryocystitis after punctal occlusion of keratoconjunctivitis sicca. (2039051)
1991
46
A new perspective on canine keratoconjunctivitis sicca. Treatment with ophthalmic cyclosporine. (2194349)
1990
47
Keratoconjunctivitis sicca associated with fracture of the stylohyoid bone in a horse. (2917892)
1989
48
Superior limbic keratoconjunctivitis (SLK). (2695351)
1989
49
Limbal vernal keratoconjunctivitis with a hypertrophic limbal mass lesion. (3566030)
1987
50
Keratoconjunctivitis sicca and the treatment of canine colitis. (2878518)
1986

Variations for Keratoconjunctivitis

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Expression for genes affiliated with Keratoconjunctivitis

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Expression patterns in normal tissues for genes affiliated with Keratoconjunctivitis

Search GEO for disease gene expression data for Keratoconjunctivitis.

Pathways for genes affiliated with Keratoconjunctivitis

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Pathways related to Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL5, IL4
2
Show member pathways
9.6CCL11, CCL22
39.4CCL11, IL4, IL5
49.4CCL11, IL4, IL5
59.3IL4, IL5, IL13
69.3IL4, IL5, IL13
7
Show member pathways
9.3IL4, IL5, IL13
89.3IL13, IL5, IL4
99.3IL13, IL5, IL4
109.1IL3, IL5, IL4
11
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.1IL3, IL5, IL4
129.0IL3, IL4, NGF
13
Show member pathways
Type III interferon signaling37
8.7IL4, IL5, IL3, IL13
14
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
8.7IL4, IL5, IL3, IL13
158.7IL4, IL5, IL3, IL13
16
Show member pathways
7.9IL13, IL3, IL5, IL4, CCL11, RNASE3
17
Show member pathways
7.8CCL22, CCL11, IL4, IL5, IL3, IL13
18
Show member pathways
7.8CCL22, CCL11, IL4, IL5, IL3, IL13
19
Show member pathways
7.8CCL22, CCL11, IL4, IL5, IL3, IL13
20
Show member pathways
7.8CCL22, CCL11, IL4, IL5, IL3, IL13
21
Show member pathways
7.8CCL22, CCL11, IL4, IL5, IL3, IL13

Compounds for genes affiliated with Keratoconjunctivitis

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Compounds related to Keratoconjunctivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1unicap449.7IL5, RNASE3, CCL11
2omalizumab44 1110.6IL13, IL5, IL4
3lte4449.5IL5, CCL11, RNASE3
4sodium cromoglycate449.5CCL11, RNASE3, IL5
5ovomucoid449.5IL13, IL4, IL5
6pranlukast44 28 1111.4IL4, IL5, CCL11, RNASE3
7formoterol44 28 1111.3IL13, RNASE3, IL4
8cetirizine44 28 24 1112.3CCL11, RNASE3, IL5
9rolipram44 61 2811.3IL13, CCL11, IL5, IL4
10salbutamol44 50 28 24 1113.3RNASE3, IL5, IL13, CCL11
11praziquantel44 1110.3IL4, RNASE3, IL5, IL13
12pgd2449.3CCL11, IL5, RNASE3, IL13
13nedocromil sodium449.1IL5, RNASE3, IL4, IL3
14azelastine44 1110.1IL4, RNASE3, IL3, IL5
15poly(i-c)449.1IL3, IL5, IL4, CCL11
16gm-csf44 2810.0IL4, IL5, IL3, IL13
17n-formylmethionyl-leucylphenylalanine449.0CCL11, IL5, RNASE3, IL3
18ltd4449.0IL13, IL3, RNASE3, IL5
19mip 1alpha449.0IL13, IL4, IL3
20salmeterol44 50 28 1112.0IL13, RNASE3, CCL11, IL4, IL5
21montelukast44 50 28 1112.0RNASE3, IL13, CCL11, IL5, IL4
22budesonide44 50 1111.0RNASE3, IL4, IL13, IL5, CCL11
23fluticasone propionate44 50 61 1112.0CCL11, RNASE3, IL13, IL5, IL4
24il 10448.9IL4, IL13, IL3, IL5
25theophylline44 28 24 1111.9IL5, RNASE3, IL13, NGF
26tarc448.9CCL22, IL13, IL5, CCL11, IL4
27prednisolone44 28 1110.8IL13, NGF, IL5, CCL11, RNASE3
28ltc4448.8RNASE3, CCL11, IL5, IL3, IL13
29ionomycin448.7CCL11, IL5, IL13, IL3, IL4
30indomethacin44 28 61 1111.7IL13, IL4, CCL11, NGF, IL5
31herbimycin a44 619.7IL3, NGF, CCL11, IL4, IL5
32fmlp448.7RNASE3, IL13, IL3, IL5, CCL11
33capsaicin44 289.6CMA1, IL5, RNASE3, NGF
34methacholine44 50 1110.5IL5, CCL22, CCL11, RNASE3, IL4, IL13
35pge2448.4CCL22, IL13, IL5, IL4, CCL11, RNASE3
36sb 20358044 619.3NGF, CCL22, CCL11, IL4, IL13, IL5
37aspirin44 50 28 2411.3NGF, RNASE3, CCL22, CCL11, IL4, IL13
38tacrolimus44 50 1110.3CCL22, IL4, IL3, IL5, IL13, CCL11
39leukotriene b444 61 2410.2IL3, CCL11, IL5, IL13, CCL22, RNASE3
40ly294002448.2NGF, IL5, IL4, IL13, IL3, CCL11
41allergens448.2RNASE3, CCL11, CMA1, IL13, IL4, IL5
42thymidine44 249.2CCL11, IL4, IL3, IL5, IL13, NGF
43vegf448.0IL4, NGF, RNASE3, CCL11, IL5, IL13
44actinomycin d447.9IL3, IL4, IL13, CCL11, NGF
45rantes447.9IL5, CCL22, IL4, IL3, CCL11, RNASE3
46heparin44 28 24 1110.8RNASE3, CMA1, CCL11, IL5, IL13, IL3
47adenylate447.6NGF, RNASE3, IL13, IL3, IL5, IL4
48cyclosporin a44 28 619.4IL4, IL5, IL3, CCL11, IL13, CCL22
49dexamethasone44 50 28 1110.3NGF, IL13, RNASE3, CCL22, CCL11, IL4
50histamine44 28 248.5IL3, RNASE3, CMA1, CCL22, CCL11, NGF

GO Terms for genes affiliated with Keratoconjunctivitis

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Cellular components related to Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.3CCL22, CCL11, IL4, IL5, IL3, IL13
2extracellular regionGO:0055766.2IL13, NGF, RNASE3, CMA1, CCL22, CCL11

Biological processes related to Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1regulation of proton transportGO:0101559.8IL13, IL4
2response to radiationGO:0093149.6NGF, CCL11
3positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.6IL3, IL4
4response to nicotineGO:0350949.6NGF, IL13
5positive regulation of B cell proliferationGO:0308909.5IL13, IL5, IL4
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.5IL3, IL5
7positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4NGF, IL4, IL5
8chemotaxisGO:0069359.4IL4, CCL11, CCL22
9extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.3IL4, NGF
10cell-cell signalingGO:0072678.8IL13, IL3, CCL22
11inflammatory responseGO:0069548.5NGF, CCL22, CCL11, IL5, IL13
12immune responseGO:0069558.1IL13, IL3, IL5, IL4, CCL11, CCL22

Molecular functions related to Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.6CCL11, CCL22
2growth factor activityGO:0080838.5NGF, IL4, IL5, IL3
3cytokine activityGO:0051258.4IL13, IL4, IL5, IL3

Products for genes affiliated with Keratoconjunctivitis

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Sources for Keratoconjunctivitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet