MCID: KRT006
MIFTS: 60

Keratoconjunctivitis malady

Infectious diseases, Eye diseases categories

Summaries for Keratoconjunctivitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Keratoconjunctivitis is inflammation (\"-itis\") of the cornea and conjunctiva. more...

MalaCards: Keratoconjunctivitis, also known as certain types of keratoconjunctivitis, is related to keratoconjunctivitis sicca and conjunctivitis. An important gene associated with Keratoconjunctivitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Selected targets of GCR-alpha and OX40 Pathway. The drugs lodoxamide tromethamine and lodoxamide and the compounds pge2 and hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related mouse phenotypes are homeostasis/metabolism and respiratory system.

Aliases & Classifications for Keratoconjunctivitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 27ICD9CM, 25ICD10
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Related Diseases for Keratoconjunctivitis

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17GeneCards, 18GeneDecks
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Diseases related to Keratoconjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 264)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis sicca31.6LTF, HSPG2
2conjunctivitis30.7RNASE3, IGHE
3keratitis30.6CXCL9
4corneal ulcer30.5NGF, PRG2, CCL11
5vernal keratoconjunctivitis30.5VCAM1, CMA1, IL4, IL5, IL3, IL13
6allergic conjunctivitis30.4IL4, IL5, IL13, RNASE3, IGHE, CCL11
7sjogren's syndrome30.4CXCL9, CXCR3, LTF, HSPG2
8dermatitis30.4VCAM1, CMA1, IL4, IL5, IL13, CXCL9
9arthritis30.3MMP1, MMP3, IL4, IL13, CXCL9, CXCR3
10rheumatoid arthritis30.3VCAM1, MMP1, MMP3, IL4, IL13, CXCL9
11atopic dermatitis30.2VCAM1, CMA1, IL4, IL5, IL13, CXCL9
12eye disease30.2NGF
13uveitis30.2IL4, CXCL9, CXCR3, CCL11
14encephalitis30.2VCAM1, CXCL9, CCL5
15giant papillary conjunctivitis30.1IL5, RNASE3, LTF, CCL11
16graft versus host disease30.1IL4, IL3, IL13, CCL5
17dry eye syndrome30.1LTF, HSPG2
18erythema multiforme29.9HSPG2
19lichen planus29.9CXCL9, CXCR3
20esophagitis29.9IL5, IL13, PRG2, CCL11
21herpes simplex29.9CCL5
22glaucoma29.9MMP1
23sarcoidosis29.9IL13, CXCL9, CXCR3, CCL5, CCL11
24influenza29.9CXCL9, CXCR3, LTF, CCL5, CCL11
25eosinophilia29.9VCAM1, IL4, IL5, IL3, IL13, RNASE3
26asthma29.9IL13, CCL11
27peritonitis29.7CMA1
28stevens-johnson syndrome29.7HSPG2
29hypertension29.7VCAM1
30otitis media29.7RNASE3, LTF, IGHE, CCL11
31tuberculosis29.7IL4, CXCL9, CXCR3
32diabetes mellitus29.7VCAM1, MMP3, NGF
33common variable immune deficiency29.7IL4
34allergic rhinitis29.7IL4, IL5, IL13, RNASE3, IGHE, CCL11
35obesity29.7MMP3, CCL5, CCL11
36pneumonia29.7IL5, IL13, CCL5, CCL11, CCL22, HSPG2
37rhinitis29.7VCAM1, CMA1, IL4, IL5, IL13, RNASE3
38allergic asthma29.7VCAM1, CMA1, IL4, IL5, IL3, IL13
39diabetic retinopathy29.7VCAM1
40conjunctivochalasis29.7MMP1, MMP3
41vernal conjunctivitis10.4
42keratoconus10.3
43superior limbic keratoconjunctivitis10.3
44corneal disease10.1
45shipyard eye10.1
46st. louis encephalitis10.1
47dacryoadenitis10.1
48papillary conjunctivitis10.1
49atopic keratoconjunctivitis10.1
50rosacea10.1

Graphical network of the top 20 diseases related to Keratoconjunctivitis:



Diseases related to keratoconjunctivitis

Clinical Features for Keratoconjunctivitis

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Drugs & Therapeutics for Keratoconjunctivitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Keratoconjunctivitis

Drug clinical trials:

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Search NIH Clinical Center for Keratoconjunctivitis

Search CenterWatch for Keratoconjunctivitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Keratoconjunctivitis

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Anatomical Context for Keratoconjunctivitis

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32MalaCards
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MalaCards organs/tissues related to Keratoconjunctivitis:

32
Eye, Testes, T cells, Bone, Salivary gland, Bone marrow, Thyroid, B cells

Animal Models for Keratoconjunctivitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Keratoconjunctivitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.1IL5, VCAM1, MMP3, IL4, HSPG2, IGHE
2MP:000538810.0CCL11, PRG2, CXCR3, CCL24
3MP:000539710.0HSPG2, CCL24, CCL11, CCL5, PRG2, IGHE
4MP:00053879.9VCAM1, HSPG2, CCL24, CCL11, CCL5, PRG2

Publications for Keratoconjunctivitis

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50PubMed
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Articles related to Keratoconjunctivitis:

(show top 50)    (show all 944)
idTitleAuthorsYear
1
Corneal sequestrum in a dog with chronic unilateral keratoconjunctivitis sicca. (24299547)
2013
2
Microvascular autologous transplantation of partial submandibular gland for severe keratoconjunctivitis sicca. (23813419)
2013
3
Adenovirus-associated epidemic keratoconjunctivitis outbreaks--four states, 2008-2010. (23945769)
2013
4
Analysis of human adenovirus type 19 associated with epidemic keratoconjunctivitis and its reclassification as adenovirus type 64. (22467570)
2012
5
Canine neurogenic Keratoconjunctivitis sicca: 11 cases (2006-2010). (22051024)
2012
6
Supratarsal injection of triamcinolone acetonide and childhood allergic keratoconjunctivitis. (22331436)
2012
7
The role of Staphylococcal enterotoxin in atopic keratoconjunctivitis and corneal ulceration. (22486642)
2012
8
Topical cyclosporine for atopic keratoconjunctivitis. (22972132)
2012
9
Acute haemorrhagic conjunctivitis epidemics and outbreaks of Paederus spp. keratoconjunctivitis ('Nairobi red eyes') and dermatitis. (21920128)
2011
10
Ocular complications of severe vernal keratoconjunctivitis (VKC) in Yemen. (23960939)
2011
11
Topical cyclosporine prevents seasonal recurrences of vernal keratoconjunctivitis in a randomized, double-masked, controlled 2-year study. (21868078)
2011
12
Characteristics of microsporidial keratoconjunctivitis in an eastern Indian cohort: a case series. (21934222)
2011
13
Vernal keratoconjunctivitis--a rare but serious comorbidity of allergic rhinitis and eustachian tube dysfunction. (19900723)
2010
14
Chlamydia pneumoniae in the etiology of the keratoconjunctivitis sicca in adult patients (a pilot study)]. (19642357)
2009
15
Conjunctival effects of canine distemper virus-induced keratoconjunctivitis sicca. (19604335)
2009
16
Preliminary studies on the etiology of keratoconjunctivitis in reindeer (Rangifer tarandus tarandus) calves in Alaska. (18957667)
2008
17
Natural killer cells in vernal keratoconjunctivitis. (17893656)
2007
18
The differences of tear function and ocular surface findings in patients with atopic keratoconjunctivitis and vernal keratoconjunctivitis. (17620070)
2007
19
Infectious bovine keratoconjunctivitis antimicrobial therapy. (17300463)
2007
20
Confocal microscopy of subepithelial infiltrates occurring after epidemic keratoconjunctivitis. (17068453)
2006
21
Clinical and microbiological profile of microsporidial keratoconjunctivitis in southern India. (16488011)
2006
22
Congenital keratoconjunctivitis sicca and ichthyosiform dermatosis in the cavalier King Charles spaniel. (16961470)
2006
23
Blinding keratoconjunctivitis and child abuse. (15652850)
2005
24
An outbreak of adenovirus type 8 keratoconjunctivitis in a nursing home in Madrid. (15075484)
2004
25
Tear and mucus eotaxin-1 and eotaxin-2 in allergic keratoconjunctivitis. (12623809)
2003
26
Vernal keratoconjunctivitis. (12544394)
2003
27
Surgical treatment of limbal vernal keratoconjunctivitis by resection of a limbal lesion. (12543198)
2002
28
Group IIA phospholipase A2 content of tears in patients with keratoconjunctivitis sicca. (12136279)
2002
29
Respiratory syncytial virus and chlamydia are not detectable by PCR in ongoing vernal keratoconjunctivitis. (11935435)
2001
30
Tear tryptase in vernal keratoconjunctivitis. (11231766)
2001
31
Growth factors and collagen distribution in vernal keratoconjunctivitis. (11095612)
2000
32
Keratoconjunctivitis sicca associated with meibomian secretion polar lipid abnormality. (9682696)
1998
33
Shield ulcers and plaques of the cornea in vernal keratoconjunctivitis. (7777308)
1995
34
Management of superior limbic keratoconjunctivitis with botulinum toxin. (7713245)
1995
35
Treatment of keratoconjunctivitis sicca: the use of a simple self-administered eye irrigation system. (8000754)
1994
36
Effect of sodium sucrose-sulfate on the ocular surface of patients with keratoconjunctivitis sicca in SjAPgren's syndrome. (8030557)
1994
37
Treatment of vernal keratoconjunctivitis a double-masked study. (22822779)
1993
38
Changes in the diagnostic parameters during keratoconjunctivitis sicca therapy. (1473446)
1992
39
A comparison of the precorneal residence of an artificial tear preparation in patients with keratoconjunctivitis sicca and normal volunteer subjects using gamma scintigraphy. (1750310)
1991
40
Vitamin A eyedrops for superior limbic keratoconjunctivitis. (3285694)
1988
41
Keratoconjunctivitis sicca in the dog associated with the administration of salicylazosulphapyridine (sulphasalazine). (2860750)
1985
42
Keratoconjunctivitis sicca--an autoimmune condition? (4090224)
1985
43
Keratoconjunctivitis sicca associated with sulfonamide therapy in dogs. (6120925)
1982
44
Sodium cromoglycate (intal) in the treatment of vernal keratoconjunctivitis and allergic conjunctivitis. (824033)
1976
45
Clinical and immunological aspects of keratoconjunctivitis sicca. (4465297)
1974
46
Keratoconjunctivitis sicca secondary to fracture of the mandible. (4488644)
1973
47
Keratoconjunctivitis sicca and new techniques in its management. (6016902)
1967
48
Atopic keratoconjunctivitis. (13411162)
1957
49
A possible relationship between viruses of St. Louis encephalitis and epidemic keratoconjunctivitis. (14844416)
1951
50
Keratoconjunctivitis sicca; a review with a survey of 121 additional cases. (15405338)
1950

Genetic Variations for Keratoconjunctivitis

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Expression for genes affiliated with Keratoconjunctivitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratoconjunctivitis

Search GEO for disease gene expression data for Keratoconjunctivitis.

Pathways for genes affiliated with Keratoconjunctivitis

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12EMD Millipore, 51QIAGEN, 52R&D Systems, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome
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Pathways related to Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IL5, CCL11, IL4
210.4IL4, IL5, IL13
310.4IL4, IL5, IL13
410.4IL4, IL5, IL3
5
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10.4IL3, IL5, IL4
610.4IL3, IL5, IL4, IL13
710.4IL13, IL4, IL5, IL3
810.4CXCL9, CCL11, CXCR3
9
Cell adhesion ECM remodeling
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10.4MMP3, MMP1, CMA1
10
Cell adhesion Cell-matrix glycoconjugates
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10.4MMP3, MMP1, CCL5
1110.4IL13, IL5, IL4, MMP1
1210.4IL4, IL5, IGHE, CCL11
13
Hide members
10.4MMP3, HSPG2, MMP1
1410.3VCAM1, IL4, CCL5, IL3
15
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10.3HSPG2, CMA1, MMP1, MMP3
16
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10.3IGHE, IL4, IL5, IL3, IL13, CCL11
1710.3CCL22, CCL11, CCL5, CXCR3, CXCL9
18
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10.3IL3, IL13, IL4, RNASE3, PRG2, CCL11
19
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10.3CCL22, CCL24, CCL11, CCL5, CXCR3, CXCL9
20
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10.3IL5, CXCR3, CCL22, PRG2, HSPG2, CCL24
21
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10.2IL4, IL3, IL5, IL13, CCL5, CCL11
22
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10.2CCL22, CCL24, CCL11, CXCL9, IL13, IL3
23
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10.2IL13, IL5, IL3, CXCL9, CXCR3, CCL5
24
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10.2CCL22, CCL24, IL4, IL5, IL3, IL13
25
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10.1CMA1, VCAM1, CXCL9, CXCR3, NGF, CCL5
26
Hide members
10.1CCL24, HSPG2, CCL11, CCL5, PRG2, VCAM1

Compounds for genes affiliated with Keratoconjunctivitis

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44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Keratoconjunctivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 211)
idCompoundScoreTop Affiliating Genes
1pge24410.9CCL11
2hydrocortisone44 2 59 1113.8IGHE, LTF, MMP1
3rantes4410.8CCL11, RNASE3, CXCR3, IL3, IL4
4indomethacin44 59 28 1113.7HSPG2, PRG2, LTF, NGF, IL5
5salmeterol44 49 28 1113.7IL4, CCL11, IL5, IL13, RNASE3, CCL5
6fluticasone propionate44 49 59 1113.7CCL11, CCL5, VCAM1, IL4, IL5, IL13
7endotoxin4410.7LTF, RNASE3, VCAM1, CXCR3
8montelukast44 49 28 1113.7IL4, IL5, IL13, RNASE3, IGHE, CCL11
9allergens4410.6IL4, CMA1, PRG2, CCL11, IGHE, RNASE3
10leukotriene b444 59 2412.6IL13, RNASE3, LTF, CCL5, CCL11, CCL22
11ltc44410.6CCL11, IL13, RNASE3, IL3, PRG2, IL5
12il 104410.6IL4, IL13, CXCL9, IL3, IL5, CCL5
13cycloheximide4410.6HSPG2
14sodium cromoglycate4410.6VCAM1, CCL11, IGHE, RNASE3, IL5
15cyclosporin a44 28 5912.6CCL22, CCL11, CCL5, IGHE, LTF, NGF
16prednisolone44 28 1112.6VCAM1, CCL11, IGHE, NGF, RNASE3, IL13
17budesonide44 49 1112.6IL13, RNASE3, LTF, IGHE, CCL5, CCL11
18dexamethasone44 49 28 1113.6LTF, RNASE3, IL13, IL3, IL5, IGHE
19capsaicin44 2811.6IGHE, HSPG2, LTF, RNASE3, IL5, CMA1
20ccl344 2811.6CCL11, CXCL9, CXCR3, CCL5, IL13, CCL22
21fmlp4410.6LTF, CCL11, PRG2, HSPG2, RNASE3, VCAM1
22methacholine44 1111.6CCL5, PRG2, IGHE, LTF, RNASE3, IL13
23groalpha4410.6CXCL9, IL13, VCAM1, CXCR3, CCL5, CCL11
24tarc4410.6IL4, IL5, IL13, CXCL9, CXCR3, IGHE
25aspirin44 49 28 2413.6HSPG2, CCL22, IL4, MMP1, IL13, RNASE3
26herbimycin a44 5911.6VCAM1, MMP1, HSPG2, IL4, IL3, NGF
27sb 20358044 5911.6IL5, IL13, IL4, NGF, CCL5, MMP3
28nedocromil sodium4410.6RNASE3, IGHE, IL4, IL5, IL3
29salbutamol44 49 28 11 2414.6IGHE, VCAM1, IL5, IL13, RNASE3, CCL11
30ly2940024410.6IL4, IL5, IL3, IL13, CXCR3, NGF
31n acetylcysteine4410.5CCL5, LTF, RNASE3, IL4, MMP3, VCAM1
32tacrolimus44 49 1112.5IL13, IL3, IL4, IL5, CCL22, CCL11
33heparin44 28 11 2413.5LTF, RNASE3, CXCR3, MMP3, CMA1, VCAM1
34adenylate4410.5VCAM1, IL13, IL3, IL4, RNASE3, NGF
35genistein44 28 59 2 11 2415.5MMP3, HSPG2, CCL11, CCL5, NGF, IL5
36pranlukast44 28 1112.5CCL5, CCL11, RNASE3, IL5, IL4
37pgd24410.4IL5, CCL11, PRG2, IGHE, RNASE3, IL13
38creatinine4410.4NGF, RNASE3, IGHE, CXCR3, CXCL9, IL3
39retinoic acid44 2411.4CCL11, CCL5, PRG2, IGHE, LTF, NGF
40pd 98,0594410.4HSPG2, CCL5, VCAM1, IL3, NGF, CXCR3
41vegf4410.4HSPG2, CCL11, CCL5, VCAM1, IGHE, LTF
42cysteine4410.4IL5, PRG2, LTF, IL13, IL3, CCL5
43actinomycin d4410.3IL4, IGHE, IL3, IL13, LTF, PRG2
44azelastine44 1111.3IL3, IL5, RNASE3, IGHE, IL4
45pertussis4410.3HSPG2, CCL11, CCL5, IGHE, LTF, CCL22
46tyrosine4410.3PRG2, CXCL9, CXCR3, RNASE3, NGF, IL3
47poly(i-c)4410.3VCAM1, IL4, IL5, IL3, CCL5, CCL11
48histamine44 28 2412.3HSPG2, IL3, IL5, IL4, MMP3, CMA1
49praziquantel44 1111.2RNASE3, IL13, IGHE, IL5, IL4
50n-formylmethionyl-leucylphenylalanine4410.0IL5, HSPG2, CCL11, LTF, IL3, RNASE3

GO Terms for genes affiliated with Keratoconjunctivitis

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16Gene Ontology
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Cellular components related to Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.3VCAM1, IL4, IL13, CXCL9, CXCR3
2extracellular regionGO:0055769.8CMA1, HSPG2, CCL22, CCL11, CCL5, PRG2
3extracellular spaceGO:0056159.7HSPG2, CCL22, CCL24, CCL11, CCL5, NGF

Biological processes related to Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:03089010.6IL13, IL5, IL4
2eosinophil chemotaxisGO:04824510.6CCL24, CCL11, CCL5
3regulation of proton transportGO:01015510.6IL13, IL4
4positive regulation of T cell proliferationGO:04210210.6IL4, VCAM1, CCL5
5chronic inflammatory responseGO:00254410.5CCL11, VCAM1
6cell-cell signalingGO:00726710.5CCL5, CCL22, CCL24, CXCL9, IL13, IL3
7chemotaxisGO:00693510.5CCL11, CXCL9, CXCR3, CCL5, CCL24, CCL22
8positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.5IL4, IL5, NGF
9inflammatory responseGO:00695410.5CCL24, CCL22, CCL5, CCL11, NGF, CXCR3
10positive regulation of JAK-STAT cascadeGO:04642710.4CCL5, IL5
11immune responseGO:00695510.4IL13, IL5, IL3, CXCL9, IGHE, PRG2
12extracellular matrix disassemblyGO:02261710.4CMA1, MMP1, MMP3
13positive regulation of angiogenesisGO:04576610.3CCL24, CCL11, CMA1
14extracellular matrix organizationGO:03019810.0HSPG2, MMP3, MMP1, CMA1

Molecular functions related to Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00808310.4IL4, IL5, IL3, NGF
2chemokine activityGO:00800910.2CCL11, CCL22, CCL24, CCL5, CXCL9
3cytokine activityGO:00512510.0IL4, CXCL9, IL13, IL3, IL5

Products for genes affiliated with Keratoconjunctivitis

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  • Antibodies
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Sources for Keratoconjunctivitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet