Keratoconjunctivitis malady

Wikipedia: Keratoconjunctivitis is inflammation (\"-itis\") of the cornea and conjunctiva.⁴⁴ more...

MalaCards: Keratoconjunctivitis, also known as certain types of keratoconjunctivitis, is related to vernal keratoconjunctivitis and keratoconjunctivitis sicca. An important gene associated with Keratoconjunctivitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Asthma and Activation of Matrix Metalloproteinases. The drugs lodoxamide tromethamine and lodoxamide and the compounds budesonide and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include t cells and b cells, and related mouse phenotypes are respiratory system and renal/urinary system.

Aliases & Descriptions:

keratoconjunctivitis 6 8 32 43 certain types of keratoconjunctivitis 6

Diseases related to keratoconjunctivitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 742)

id	Related Disease	Score	Top Affiliating Genes
1	vernal keratoconjunctivitis	35.1	VCAM1, CMA1, CD36, MMP9, IL13, IL3
2	keratoconjunctivitis sicca	32.8	CFTR, IL1A, IL4, AQP5, HSPG2, TRIM21
3	allergic conjunctivitis	31.0	IL13, IL4, IL5, CCL11, IGHE, RNASE3
4	dry eye syndrome	29.5	MUC5AC, AQP5, HSPG2, LTF
5	giant papillary conjunctivitis	28.9	CCL11, CCL24, PRG2
6	papillary conjunctivitis	28.9	CCL11, CCL24, PRG2
7	allergic rhinitis	28.8	VCAM1, IL13, IL4, IL5, IGES, IGHE
8	corneal ulcer	28.4	MUC5AC, MMP9, CCL11, NGF, PRG2
9	asthma	27.4	IL13, IL4, CCL2, CCL11, CCL5, IGES
10	conjunctivitis	24.9	VEGFA, CD79A, CD36, CD4, CD46, MMP8
11	allergic asthma	23.4	VCAM1, CD86, CD4, CD80, IL13, IL1A
12	rhinitis	19.3	RELA, VIPR1, VEGFA, VCAM1, CMA1, MUC5AC
13	chronic eosinophilic pneumonia	14.0	IL5, CCL11, RNASE3
14	helminthiasis	14.0	IL13, IL5, IGHE, RNASE3
15	cough variant asthma	14.0	IL4, IL5, IGHE, RNASE3
16	egg allergy	14.0	IL4, IL5, IGHE
17	pthirus pubis infestation	14.0	IL5, CCL11, IGHE, NGF
18	allergic bronchopulmonary aspergillosis	13.9	CFTR, IL4, IL5, IGES, IGHE
19	familial eosinophilia	13.9	IL3, IL5, PRG2
20	eosinophilic gastroenteritis	13.9	IL5, CCL11, IGES, IGHE, RNASE3, PRG2
21	respiratory syncytial virus infectious disease	13.9	IL13, IL5, CCL5
22	paragonimiasis	13.9	IL5, CCL17, IGHE, RNASE3, CXCR3
23	epidermolysis bullosa dystrophica	13.9	CD36, MMP1, MMP3
24	mastocytosis	13.9	CMA1, IL13, IL3, IL5, IGHE, RNASE3
25	kimura disease	13.8	IL13, IL4, IL5, CCL11, IGES, IGHE
26	food allergy	13.8	IL13, IL4, IL5, CCL11, IGES, IGHE
27	intrinsic asthma	13.8	IL3, IL4, IL5, CCL7, CCL5, IGES
28	rheumatoid vasculitis	13.8	VCAM1, ICAM1, LTF
29	malignant ovarian cyst	13.8	MMP1, MMP13, MMP8
30	sorsby fundus dystrophy	13.8	MMP3, MMP9, TIMP1
31	hypothyroidism, autoimmune	13.7	AIRE, CXCL11, CXCL9
32	psoriatic arthritis	13.7	MMP1, MMP3, IL13, IL1A
33	radiculopathy	13.7	IL13, IL1A, CXCL9, CXCR3
34	common cold	13.7	CFTR, IL5, IL8, CCL11, ICAM1, RNASE3
35	eosinophilic pneumonia	13.7	IL13, IL3, IL5, CCL22, CCL11, CCL17
36	aggressive periodontitis	13.7	MMP1, MMP8, IL1A, LTF
37	perinatal necrotizing enterocolitis	13.7	LTF, HBEGF, THPO
38	bronchitis	13.7	CFTR, IL5, IL8, CCL11, IGHE, RNASE3
39	ascariasis	13.7	IL5, IL8, IGHE, RNASE3
40	carotid artery disease	13.7	MMP1, MMP8, CCL2, CCL5
41	acute interstitial pneumonia	13.7	IL13, CCR4, HSPG2, CXCR3
42	osteoarthritis susceptibility 6	13.7	MMP1, MMP13, MMP3, TIMP1
43	neurocirculatory asthenia	13.7	MMP1, MMP3, IL4, HSPG2, TGFB1
44	fibromatosis, gingival	13.7	CD36, MMP1, TGFB1
45	arteriovenous malformation	13.7	VEGFA, MMP3, MMP9, IL5, RNASE3
46	bullous skin disease	13.6	ITGA6, IL8, CCL5
47	stachybotrys chartarum	13.6	IL1A, IL3, CCL7
48	corneal disease	13.6	MMP1, IL1A, NGF, TIMP1
49	allergic contact dermatitis of eyelid	13.6	IL5, CCR4, ICAM1, CXCL11, CXCL9, CXCR3
50	coronary artery aneurysm	13.6	VCAM1, CCL2, IGES, IGHE, TIMP1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 lodoxamide, lodoxamide tromethamine

MalaCards organs/tissues related to keratoconjunctivitis:

²²

MGI Mouse Phenotypes related to keratoconjunctivitis:

²⁵ (show all 22)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.2	PRG2, CCL24, CCR4, AQP5, CFTR
2	renal/urinary system phenotype	MP:0005367	9.4	EGFR, TRIM21, F2RL1, ITGA6
3	skeleton phenotype	MP:0005390	8.8	F2RL1, SMAD2, EGFR, HBEGF, FGF2, MMP9
4	hematopoietic system phenotype	MP:0005397	8.7	CXADR, CD86, CD80, ITGA6, FGF2, IL3
5	endocrine/exocrine gland phenotype	MP:0005379	8.7	NRTN, AIRE, IFNG, AQP5, IL2, VIPR1
6	liver/biliary system phenotype	MP:0005370	8.5	EGFR, SMAD2, AIRE, HSPG2, IFNG, IL2
7	reproductive system phenotype	MP:0005389	8.3	TGFB1, TIMP1, CRISP3, SMAD2, NRTN, IFNG
8	no phenotypic analysis	MP:0003012	8.2	F2RL1, AIRE, SMAD2, EGFR, AQP5, IL13
9	growth/size phenotype	MP:0005378	7.9	HSPG2, AIRE, SMAD2, NGF, EGFR, HBEGF
10	integument phenotype	MP:0010771	7.6	TRIM21, SMAD2, NGF, EGFR, HBEGF, F2RL1
11	muscle phenotype	MP:0005369	7.6	ICAM1, HSPG2, NRTN, EGFR, HBEGF, TGFB1
12	vision/eye phenotype	MP:0005391	7.5	ICAM1, HSPG2, AIRE, NRTN, SMAD2, NGF
13	tumorigenesis	MP:0002006	7.5	ICAM1, F2RL1, AIRE, SMAD2, EGFR, TIMP1
14	behavior/neurological phenotype	MP:0005386	7.4	AIRE, NRTN, SMAD2, NGF, HBEGF, TIMP2
15	normal phenotype	MP:0002873	7.1	SMAD2, TMSB4X, AIRE, IFNG, CCL11, IL4
16	digestive/alimentary phenotype	MP:0005381	6.6	HSPG2, AIRE, NRTN, SMAD2, EGFR, TSLP
17	nervous system phenotype	MP:0003631	6.4	ICAM1, F2RL1, HSPG2, AIRE, NRTN, SMAD2
18	cardiovascular system phenotype	MP:0005385	6.2	ICAM1, F2RL1, HSPG2, TMSB4X, SMAD2, EGFR
19	immune system phenotype	MP:0005387	5.8	TSLP, CXADR, EGFR, LTF, ITGA6, CD80
20	mortality/aging	MP:0010768	5.6	NGF, SMAD2, SSB, TRIM21, EGFR, HBEGF
21	homeostasis/metabolism phenotype	MP:0005376	5.1	TRIM21, AIRE, HSPG2, F2RL1, ICAM1, IGHE
22	cellular phenotype	MP:0005384	4.5	F2RL1, ICAM1, IFNG, CCL5, CCL2, IL4

Articles related to keratoconjunctivitis:

(show top 50)    (show all 57)

id	Title	Authors	Year	Affiliating Genes
1	Overexpression of matrix metalloproteinase-1 (MMP-1) and MMP-3 in superior limbic keratoconjunctivitis. (21357403)	Sun Y.C.... Hu F.R.	2011	MMP3, MMP1
2	Transforming growth factor-I^/Smad - signalling pathwa y and conjunctival remodelling in vernal keratoconjunctivitis. (20977504)	Leonardi A.... Brun P.	2011	TGFB1, SMAD2
3	Vernal keratoconjunctivitis--a rare but serious comor bidity of allergic rhinitis and eustachian tube dysfunction. (19900723)	Bozkurt M.K.... Reisli I.	2010	IGHE
4	Functional role of thymic stromal lymphopoietin in ch ronic allergic keratoconjunctivitis. (19741251)	Matsuda A.... Murakami A.	2010	TSLP
5	Evaluation of eotaxin-1, -2, and -3 protein production and messenger RNA expression in patients with vernal keratoconjunctivitis. (19333691)	Shoji J.... Sawa M.	2009	CCL11, CCL24
6	Cytokines, matrix metalloproteases, angiogenic and growth factors in tears of normal subjects and vernal keratoconjunctivitis patients. (19220217)	Leonardi A.... Sack R.	2009	MMP3, MMP8, MMP13
7	Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis. (18782111)	Dogru M.... Fujishima H.	2008	MUC5AC, MUC16
8	Nerve growth factor has a modulatory role on human primary fibroblast cultures derived from vernal keratoconjunctivitis-affected conjunctiva. (17653039)	Micera A.... Bonini S.	2007	NGF
9	Matrix metalloproteases in vernal keratoconjunctivitis, nasal polyps and allergic asthma. (17517101)	Leonardi A.... Abatangelo G.	2007	PITRM1
10	SjAPgren's syndrome-like disease of C57BL/6.NOD-Aec1 Aec2 mice: gender differences in keratoconjunctivitis sicca defined by a cross-over in the chromosome 3 Aec1 locus. (16918699)	Nguyen C.... Peck A.B.	2006	HSPG2
11	Immunopathogenesis of conjunctival remodelling in vernal keratoconjunctivitis. (15746957)	Abu El-Asrar A.M.... Geboes K.	2006	EGFR, FGF2, VEGFA
12	Expression of B7 molecules and TLR-9 on corneal epithelial cells infected with adenovirus: clinico-pathological implications in viral keratoconjunctivitis (16888692)	Jimenez-Martinez M.C.... Garfias Y.	2006	CD80
13	Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)	Shoji J.... Sawa M.	2006	CCL24
14	Topical 0.1% prednisolone lowers nerve growth factor expression in keratoconjunctivitis sicca patients. (16360211)	Lee H.K.... Kim E.K.	2006	NGF
15	Conjunctival expression of thymosin-beta4 in vernal keratoconjunctivitis. (17200658)	Micera A.... Rasi G.	2006	TMSB4X
16	Long eyelashes in a case series of 93 children with vernal keratoconjunctivitis. (15629970)	Pucci N.... Vierucci A.	2005	IGES
17	Chemokine receptor gene expression in giant papillae of atopic keratoconjunctivitis. (15788997)	Yamagami S.... Amano S.Y.	2005	CCR4, CCL22
18	Membrane cofactor protein is a receptor for adenoviruses associated with epidemic keratoconjunctivitis. (15047806)	Wu E.... Nemerow G.R.	2004	CD46, SLC7A5
19	Activation of nuclear factor-kappa B in the conjunctiva with the epithelial scraping of the mouse cornea and human epidemic keratoconjunctivitis. (15205244)	Kase S.... Yoshida K.	2004	RELA
20	Tear chymase in vernal keratoconjunctivitis. (15512949)	Ebihara N.... Murakami A.	2004	CMA1
21	Allergic chronic inflammation of the ocular surface in vernal keratoconjunctivitis. (14501439)	Bonini S.... Bonini S.	2003	IL3, IL4, CCL5
22	Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. (14507865)	Song X.J.... Pflugfelder S.C.	2003	NRTN
23	The T-lymphocyte chemoattractant Mig is highly expressed in vernal keratoconjunctivitis. (14597036)	Abu El-Asrar A.M.... Geboes K.	2003	CXCL11, CXCL9
24	Neutrophil and eosinophil participation in atopic and vernal keratoconjunctivitis. (12868012)	Trocme S.D.... Dohlman C.H.	2003	PRG2, CRISP3
25	Immunopathogenesis of conjunctival histopathologic alteration in non-Sjogren's keratoconjunctivitis sicca. (12613995)	Ye H.Q.... Smith J.A.	2002	IL4, IL1A
26	Toxic eosinophil granule protein deposition in corneal ulcerations and scars associated with atopic keratoconjunctivitis. (12470748)	Messmer E.M.... Kampik A.	2002	PRG2
27	High level of Fc epsilon receptor I-bindable immunoglobulin E in the tear fluid and increased immunoglobulin E-saturated cells in the giant papillae of vernal keratoconjunctivitis patients. (12225812)	Ebihara N.... Ra C.	2002	IGHE
28	Langerhans' cells in vernal keratoconjunctivitis express the costimulatory molecule B7-2 (CD86), but not B7-1 (CD80). (11702979)	Abu-El-Asrar A.M.... Geboes K.	2001	CD86
29	Expression of chemokine receptors in vernal keratoconjunctivitis. (11673306)	Abu El-Asrar A.M.... Geboes K.	2001	CXCR3
30	Gelatinase B in vernal keratoconjunctivitis. (11594952)	Abu El-Asrar A.M.... Geboes K.	2001	MMP9
31	Chemokines in the limbal form of vernal keratoconjunctivitis. (11090473)	Abu El-Asrar A.M.... Geboes K.	2000	CCL2, CCL11, CCL5
32	Tear levels of interferon-gamma, interleukin (IL) -2, IL-4 and IL-5 in patients with vernal keratoconjunctivitis, atopic keratoconjunctivitis and allergic conjunctivitis. (10606937)	Uchio E.... Ohno S.	2000	IL4, IL5
33	The immunomodulatory effect of topical cyclosporin A in atopic keratoconjunctivitis. (9950598)	Hingorani M.... Lightman S.	1999	IL2, IL3, IL4
34	Presence of eotaxin in tears of patients with atopic keratoconjunctivitis with severe corneal damage. (10359913)	Fukagawa K.... Hirai K.	1999	CCL11
35	Increased plasma levels of substance P in vernal keratoconjunctivitis. (9331280)	Lambiase A.... Aloe L.	1997	NGF
36	Effect of lodoxamide and disodium cromoglycate on tear eosinophil cationic protein in vernal keratoconjunctivitis. (9135403)	Leonardi A.... Secchi A.G.	1997	RNASE3
37	Adhesion molecules in vernal keratoconjunctivitis. (9497473)	Abu El-Asrar A.M.... Desmet V.	1997	ICAM3
38	ICAM-1 expression in corneal epithelium of a patient with vernal keratoconjunctivitis: case report. (8985642)	Gill K.S.... TrocmAc S.D.	1997	ICAM1
39	Immunopathogenesis of vernal keratoconjunctivitis. (9009358)	Abu El-Asrar A.M.... Missotten L.	1996	ICAM3
40	Increased plasma levels of nerve growth factor in vernal keratoconjunctivitis and relationship to conjunctival mast cells. (7657550)	Lambiase A.... Aloe L.	1995	NGF, IGHE
41	Collagen types I and III in giant papillae of vernal keratoconjunctivitis. (7612563)	Leonardi A.... Secchi A.G.	1995	CD36
42	Eosinophil cationic protein in tears of normal subjec ts and patients affected by vernal keratoconjunctivitis. (8588697)	Leonardi A.... Plebani M.	1995	RNASE3
43	Histaminase activity in patients with vernal keratoconjunctivitis. (9098303)	Abelson M.B.... Secchi A.G.	1995	ABP1
44	Vernal keratoconjunctivitis: a model of 5q cytokine gene cluster disease. (7613225)	Bonini S.... Rutella S.	1995	IGHE
45	Measurement of IL-4 in tears of patients with seasonal allergic conjunctivitis and vernal keratoconjunctivitis. (7586697)	Fujishima H.... Tsubota K.	1995	IL4
46	IgE, IgE receptors, and other immunocytochemical markers in atopic and nonatopic patients with vernal keratoconjunctivitis. (7777271)	Montan P.G.... Scheynius A.	1995	IGHE
47	Successful penetrating keratoplasty in a patient with severe atopic keratoconjunctivitis and elevated serum IgE level treated with l ong-term topical cyclosporin A. (7842716)	Geggel H.S.	1994	IGHE
48	Rapid assay of lactoferrin in keratoconjunctivitis si cca. (7842709)	McCollum C.J.... Cavanagh H.D.	1994	LTF
49	Increased serum levels of eosinophil cationic protein and eosinophil-derived neurotoxin (protein X) in vernal keratoconjunctivitis. (7800361)	Tomassini M.... Bonini S.	1994	RNASE3
50	The diagnostic power of the tests for tear gland rela ted keratoconjunctivitis sicca. (1603200)	Klaassen-Broekema N.... van Bijsterveld O.P.	1992	LTF

Genes related to keratoconjunctivitis according to GeneCards:

(show top 50)    (show all 77)

id	Symbol	Description	Score	GeneCards Section Context
1	CCL11	chemokine (C-C motif) ligand 11	11.0	Publications
2	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
3	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
4	NGF	nerve growth factor (beta polypeptide)	11.0	Publications
5	IL13	interleukin 13	11.0	Publications
6	IL4	interleukin 4	11.0	Publications
7	CCL24	chemokine (C-C motif) ligand 24	11.0	Publications
8	IGES	immunoglobulin E concentration, serum	11.0	Publications
9	CMA1	chymase 1, mast cell	11.0	Publications
10	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
11	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
12	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
13	LTF	lactotransferrin	11.0	Publications
14	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
15	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
16	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
17	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0	Publications
18	HSPG2	heparan sulfate proteoglycan 2	11.0	Publications
19	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
20	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
21	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
22	ICAM1	intercellular adhesion molecule 1	11.0	Publications
23	CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	11.0
24	NRTN	neurturin	11.0	Publications
25	ICAM3	intercellular adhesion molecule 3	11.0	Publications
26	PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	11.0	Publications
27	LYZ	lysozyme	11.0
28	CCL8	chemokine (C-C motif) ligand 8	11.0	Publications
29	TMSB4X	thymosin beta 4, X-linked	11.0	Publications
30	CETN2	centrin, EF-hand protein, 2	11.0
31	CCL1	chemokine (C-C motif) ligand 1	11.0	Publications
32	CRISP3	cysteine-rich secretory protein 3	11.0	Publications
33	CCL22	chemokine (C-C motif) ligand 22	11.0	Publications
34	CXCL11	chemokine (C-X-C motif) ligand 11	11.0	Publications
35	MMP10	matrix metallopeptidase 10 (stromelysin 2)	11.0	Publications
36	CCL17	chemokine (C-C motif) ligand 17	11.0	Publications
37	ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	11.0	Publications
38	CCL7	chemokine (C-C motif) ligand 7	11.0	Publications
39	PITRM1	pitrilysin metallopeptidase 1	11.0	Publications
40	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
41	SRCIN1	SRC kinase signaling inhibitor 1	11.0
42	THPO	thrombopoietin	11.0	Publications
43	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0	Publications
44	CD86	CD86 molecule	11.0	Publications
45	HBEGF	heparin-binding EGF-like growth factor	11.0	Publications
46	AIRE	autoimmune regulator	11.0
47	ITGA6	integrin, alpha 6	11.0	Publications
48	CD46	CD46 molecule, complement regulatory protein	11.0	Publications
49	F2RL1	coagulation factor II (thrombin) receptor-like 1	11.0
50	CXADR	coxsackie virus and adenovirus receptor	11.0

Pathways related to keratoconjunctivitis according to GeneDecks:

(show top 50)    (show all 123)

id	Pathway	Score	Top Affiliating Genes
1	Asthma20	10.5	PRG2, CCL11, IL3, IL4, IL13, RNASE3
2	Activation of Matrix Metalloproteinases38	10.0	CMA1, MMP1, MMP10, MMP13, TIMP2, TIMP1
3	Metalloproteases in connective tissue degradation10	10.0	MMP3, MMP13, MMP8, MMP10, MMP1, MMP9
4	Inhibition of Matrix Metalloproteinases36	10.0	MMP1, MMP3, MMP8, MMP9, MMP13, MMP10
5	Class A/1 (Rhodopsin-like receptors)38	9.9	CCL22, CCR4, CCL7, CCL11, CCL17, CXCR3
6	Glioma Invasiveness36	9.9	THPO, ITGA6, FGF2, IL3, TIMP1
7	Cell adhesion ECM remodeling10	9.6	EGFR, IL8, MMP13, MMP1, MMP9, MMP10
8	Cell adhesion_ECM remodeling41	9.6	TIMP2, TIMP1, HBEGF, EGFR, IL8, MMP9
9	Chemokine Signaling36	9.5	CCL8, CCL22, CXCR3, CCL7, CCL2, CCR4
10	UPA-UPAR Pathway36	9.5	MMP3, ITGA6, MMP1, MMP10, MMP13, MMP8
11	Hematopoietic cell lineage20	9.4	ITGA6, IL1A, IL3, IL4, THPO, CD4
12	IL-6 Pathway36	9.4	IL3, CD80, CCL5, CCL24, CCL1, CCL11
13	RAR-Gamma-RXR-Alpha Degradation36	9.3	CCL1, CCL24, CCL5, CXCL11, CXCL9, CCL17
14	Chemokine signaling pathway20	9.1	CXCR3, CXCL9, CXCL11, CCL5, RELA, IL8
15	Malaria20	9.1	IL8, ICAM1, TGFB1, IFNG, CCL2, CD36
16	Endothelin-1 Signaling Pathway36	8.9	IL5, IL4, IL3, IL2, IL1A, IL13
17	Cytokine Network36	8.9	IL1A, IL2, IL8, IL13, IL5, IFNG
18	Transendothelial Migration of Leukocytes36	8.8	VCAM1, ITGA6, MMP1, MMP10, MMP13, MMP3
19	Pancreatic Adenocarcinoma36	8.8	MMP13, IL2, MMP3, FGF2, MMP8, MMP9
20	Renin-Angiotensin Pathway36	8.7	THPO, VCAM1, FGF2, IL3, CCL8, CCL7
21	MIF Regulation of Innate Immune Cells36	8.6	CCL2, CD80, IL13, CCL22, CCL7, CCL8
22	MIF Mediated Glucocorticoid Regulation36	8.6	CXCL9, CXCL11, CCL5, CCL24, CCL1, CCL17
23	Immune response_MIF-mediated glucocorticoid regulation41	8.6	IL8, IFNG, RELA, IL2, MMP1, VCAM1
24	all-trans-Retinoic Acid Signaling in Brain36	8.6	CCL7, CCL8, IL8, IL5, IL4, IL3
25	JNK Pathway36	8.6	TGFB1, THPO, CCL11, CCL7, CCL8, IL3
26	Immune response MIF-mediated glucocorticoid regulation10	8.6	ICAM1, MMP1, RELA, VCAM1, IL2, IL8
27	Chagas disease (American trypanosomiasis)20	8.6	RELA, SMAD2, IFNG, CCL5, CCL2, TGFB1
28	NF-KappaB (p50-p65) Pathway36	8.5	TGFB1, TIMP2, TIMP1, THPO, EGFR, IL3
29	Regulation of eIF4 and p70S6K36	8.5	CD4, CD80, ITGA6, IL13, IL1A, IL2
30	NFAT Signaling and Lymphocyte Interactions36	8.4	CD4, CD80, IL13, IL1A, IL2, IL3
31	NF-KappaB Family Pathway36	8.4	TIMP1, TGFB1, THPO, FGF2, RELA, IL3
32	Rheumatoid arthritis20	8.4	MMP3, IL1A, CCL2, IFNG, IL8, ICAM1
33	PGC1Alpha Pathway36	8.4	CD4, CD80, IL13, IL1A, IL2, IL3
34	PEDF Induced Signaling36	8.2	CCL11, CCL2, CCL22, CCL7, CCL8, IL8
35	ERK Signaling36	8.1	CCL24, CCL1, CCL17, CCL7, CCL8, IL5
36	SOCS Pathway36	8.0	FGF2, IL13, IL1A, IL2, IL3, IL4
37	Akt Signaling36	8.0	CXCR3, CCL7, CCL8, IL4, IL2, ITGA6
38	Glucocorticoid Receptor Signaling36	8.0	IL4, IL5, IL8, CCL8, CCL7, CCL22
39	STAT3 Pathway36	7.8	CD4, CD80, IL13, IL1A, IL2, CXCR3
40	PAK Pathway36	7.6	IL5, IL4, IL3, IL2, IL1A, IL13
41	NFAT in Immune Response36	7.5	FGF2, IL2, CD4, CD79A, CD86, TGFB1
42	Rho Family GTPases36	7.4	CCL11, CCL17, CCL1, CCL24, CCL5, HSPG2
43	Molecular Mechanisms of Cancer36	7.3	CD4, CXCL9, CXCL11, PRG2, TGFB1, IL3
44	MAPK Family Pathway36	7.2	CCL22, CCL2, CCL11, CCL17, CCL1, CCL24
45	TGF-Beta Pathway36	7.2	CCL5, EGFR, TIMP1, TIMP2, THPO, TGFB1
46	Cytokine-cytokine receptor interaction20	7.2	IL3, CXCL9, CXCR3, CXCL11, TGFB1, IL4
47	Tec Kinases Signaling36	6.8	IL4, IL5, IL8, CCL8, CCL7, CCL22
48	Antioxidant Action of Vitamin-C36	6.8	CXCR3, CXCL9, CXCL11, TGFB1, CCL22, CCL7
49	p38 Signaling36	6.7	TGFB1, THPO, TIMP2, TIMP1, EGFR, CCL5
50	JAK-STAT Pathway36	6.4	CCL5, IFNG, EGFR, TIMP1, TIMP2, THPO

Compounds related to keratoconjunctivitis according to GeneDecks:

(show top 50)    (show all 336)

id	Compound	Score	Top Affiliating Genes
1	budesonide32 42 9 9	13.4	CD36, CCL11, IGHE, F2RL1, RNASE3, LTF
2	endotoxin32	10.1	CD86, CCL8, CCL11, F2RL1, LTF, ABP1
3	(4-aminophenyl)mercuric acetate32	9.7	CD36, MMP1, MMP10, MMP13, MMP3, MMP8
4	leukotriene b432 42 18	11.5	MMP9, IL13, IL1A, IL3, IL5, IL8
5	tgf beta132	9.4	VCAM1, CD36, MMP1, MMP13, MMP3, MKI67
6	batimastat32 42 9 9	12.4	CD36, MMP1, MMP10, MMP13, MMP3, MMP8
7	hyaluronic acid32 18	10.4	MUC16, CD36, MMP1, MMP13, MMP3, FGF2
8	methacholine32 9 9	11.3	CD79A, IL13, IL4, IL5, IL8, CCL22
9	h2o232	9.2	MUC16, CFTR, CD79A, MMP8, IL13, IL3
10	fluticasone propionate32 42 9 9	12.2	VCAM1, MMP9, IL13, IL4, IL5, IL8
11	fmlp32	9.2	VCAM1, IL13, IL1A, IL3, IL5, IL8
12	ly29400232	9.1	VEGFA, MMP9, FGF2, IL13, IL4, IL8
13	estrogen32	9.0	MUC5AC, CFTR, CD36, MMP1, MMP13, MMP3
14	n acetylcysteine32	9.0	VCAM1, MUC5AC, CFTR, CD79A, MMP1, MMP3
15	fibrinogen32	8.9	VCAM1, CD79A, ITGA6, MMP13, MMP8, CCL22
16	ccl432	8.9	MMP13, IL13, CCL8, CCL7, CCL22, CCL2
17	curcumin32	8.9	VEGFA, VCAM1, CFTR, MMP1, MMP13, MMP3
18	matrigel32	8.5	VEGFA, VCAM1, CD36, ITGA6, MMP1, MMP10
19	hydrocortisone32 9 9	10.4	CD36, MMP1, FGF2, IL13, IL1A, IL2
20	pge232	8.3	VCAM1, MUC5AC, CFTR, CD86, CD4, MMP1
21	polysaccharide32	8.3	VCAM1, CD79A, CD4, CD46, FGF2, IL13
22	sb 20358032 42	9.2	VEGFA, VCAM1, CD36, MMP1, MMP13, MMP3
23	lactate32	8.2	VCAM1, MUC16, CD79A, MMP1, MMP3, MMP8
24	allergens32	8.1	CMA1, CD79A, CD86, CD80, IL13, IL4
25	heparin32 9 18 9	11.1	CMA1, CD79A, CD36, CD4, MMP13, MMP3
26	gm-csf32	8.0	VEGFA, IL13, IL1A, IL2, IL3, IL4
27	pd 98,05932	7.9	VCAM1, MUC5AC, ITGA6, MMP1, MMP13, MMP3
28	ccl332	7.7	MMP9, IL13, IL1A, IL8, CCL8, CCL7
29	histamine32 18	8.7	VCAM1, CMA1, MUC5AC, CD79A, CD86, IL13
30	prednisolone32 9 9	9.7	VCAM1, MUC16, CD79A, MMP1, MMP13, MMP3
31	thymidine32 18	8.6	MMP13, MKI67, FGF2, IL13, IL1A, IL2
32	indomethacin32 9 9	9.6	CFTR, CD79A, MMP1, MMP13, MMP3, IL13
33	vegf32	7.5	VCAM1, MUC16, CD36, ITGA6, MMP1, MMP10
34	phosphatidylinositol32	7.5	VCAM1, MUC5AC, CD4, CD80, CD46, MMP13
35	cysteine32	7.3	CMA1, MUC5AC, CFTR, CD79A, CD4, MMP1
36	tarc32	7.2	CD4, IL13, IL1A, IL4, IL5, IL8
37	alanine32	7.1	VIPR1, VCAM1, CFTR, CD79A, CD4, CD46
38	retinoic acid32 42 18	9.0	VIPR1, VCAM1, CFTR, CD79A, CD36, ITGA6
39	herbimycin a32 42	7.9	VCAM1, CD36, CD4, ITGA6, MMP1, MMP13
40	actinomycin d32	6.7	VIPR1, VEGFA, CFTR, MMP13, MMP9, FGF2
41	paraffin32	6.6	RELA, VEGFA, VCAM1, CMA1, MUC16, MUC5AC
42	nitric oxide32 9 18 9	9.3	VIPR1, VCAM1, MUC5AC, CD86, CD80, CD46
43	genistein32 9 18 9	9.2	VEGFA, VCAM1, CFTR, CD36, CD4, MMP1
44	rantes32	6.0	VCAM1, CD4, CD46, MMP1, MMP13, MMP3
45	cyclosporin a32 42	6.9	CFTR, CD79A, CD86, CD80, CD46, MMP1
46	cycloheximide32	5.5	VEGFA, CD36, CD86, CD4, CD80, CD46
47	calcium32 9 18 9	8.1	RELA, VIPR1, CMA1, MUC5AC, CETN2, CD36
48	serine32	4.7	RELA, VCAM1, CMA1, MUC16, MUC5AC, CFTR
49	tyrosine32	4.3	VIPR1, VEGFA, VCAM1, MUC16, MUC5AC, CD86
50	dexamethasone32 42 34 9 9	8.3	VEGFA, VCAM1, MUC16, MUC5AC, CFTR, CD79A

Cellular components related to keratoconjunctivitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	9.9	VEGFA, TMSB4X, TIMP1, TGFB1
2	proteinaceous extracellular matrix	GO:005578	9.6	TGFB1, CRISP3, MMP9, MMP8, MMP3, MMP13
3	cell surface	GO:009986	9.3	TGFB1, TIMP2, HBEGF, IL1A, CD46, CD36
4	Golgi lumen	GO:005796	9.1	TGFB1, NGF, HSPG2, MUC5AC, MUC16
5	external side of plasma membrane	GO:009897	7.8	CCR4, IFNG, ICAM1, CXCL9, CXCR3, IL4
6	extracellular region	GO:005576	6.0	LYZ, CCL2, CCL22, CCL7, IL8, IL5
7	extracellular space	GO:005615	5.4	LYZ, VEGFA, CCL7, CCL8, IL8, IL5

Biological processes related to keratoconjunctivitis according to GeneDecks:

(show top 50)    (show all 53)

id	Name	GO ID	Score	Top Affiliating Genes
1	eosinophil chemotaxis	GO:048245	10.7	CCL5, CCL24, CCL11, CCL7
2	chronic inflammatory response	GO:002544	10.7	CCL5, CCL11, VCAM1
3	response to radiation	GO:009314	10.5	TGFB1, NGF, CCL11, MMP9
4	collagen catabolic process	GO:030574	10.5	MMP9, MMP8, MMP3, MMP13, MMP10, MMP1
5	neutrophil activation	GO:042119	10.4	F2RL1, CCL5, IL8
6	response to ethanol	GO:045471	10.4	ICAM1, CCL2, IL4, IL13, MMP9
7	response to cholesterol	GO:070723	10.4	TGFB1, SMAD2, CCL5
8	chemokine-mediated signaling pathway	GO:070098	10.3	CXCR3, CCL5, CCR4, CCL2
9	regulation of cell shape	GO:008360	10.3	ICAM1, CCL24, CCL11, CCL2, CCL7, VEGFA
10	monocyte chemotaxis	GO:002548	10.3	CCL7, CCL2, CCL5
11	positive regulation of endothelial cell proliferation	GO:001938	10.3	CCL24, CCL11, CCL2, FGF2, VEGFA
12	cellular response to organic cyclic compound	GO:071407	10.2	TGFB1, CCL5, CCL2, ITGA6
13	positive regulation of angiogenesis	GO:045766	10.2	CCL5, CCL24, CCL11, IL1A, FGF2, MMP9
14	cellular calcium ion homeostasis	GO:006874	10.2	TGFB1, CCL5, CCL1, CCL11, CCL2, CCL7
15	positive regulation of B cell proliferation	GO:030890	10.2	IL5, IL4, IL2, IL13
16	MAPK cascade	GO:000165	10.1	TGFB1, EGFR, NRTN, CCL5, CCL2
17	extracellular matrix disassembly	GO:022617	10.1	TIMP2, TIMP1, MMP9, MMP8, MMP3, MMP13
18	extracellular matrix organization	GO:030198	10.1	TIMP2, TIMP1, MMP9, MMP8, MMP3, MMP13
19	proteolysis	GO:006508	10.1	MMP8, MMP9, PITRM1, LTF, MMP3, MMP13
20	leukocyte migration	GO:050900	10.0	SLC7A5, CXADR, F2RL1, ICAM1, MMP1, ITGA6
21	platelet degranulation	GO:002576	10.0	TGFB1, TIMP1, TMSB4X, CD36, VEGFA
22	aging	GO:007568	10.0	TGFB1, TIMP1, CCL5, CCL2, VCAM1
23	cellular response to tumor necrosis factor	GO:071356	10.0	ICAM1, CCL5, CCL2, IL8, RELA
24	cellular response to interleukin-1	GO:071347	9.9	ICAM1, CCL5, CCL2, IL8, MMP9, RELA
25	positive regulation of cell migration	GO:030335	9.9	TGFB1, HBEGF, EGFR, F2RL1, CCL5, CCL24
26	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.9	IL2, IL3, IL4
27	regulation of immune response	GO:050776	9.8	CXADR, ICAM3, ICAM1, IL4, VCAM1
28	response to hypoxia	GO:001666	9.7	TGFB1, CCL2, IL1A, MMP9, VCAM1, VEGFA
29	positive regulation of T cell proliferation	GO:042102	9.7	IFNG, CCL5, IL4, VCAM1
30	positive regulation of cell division	GO:051781	9.7	TGFB1, IL1A, FGF2, VEGFA
31	chemotaxis	GO:006935	9.6	CXCR3, FGF2, IL4, CXCL9, CXCL11, CCL5
32	positive regulation of interleukin-2 biosynthetic process	GO:045086	9.6	IL1A, CD80, CD4, CD86
33	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.6	IL5, IL3, CD80, CD4, CD36, VEGFA
34	cellular response to lipopolysaccharide	GO:071222	9.5	ICAM1, IFNG, CCL2, IL8, CD36
35	humoral immune response	GO:006959	9.5	LTF, AIRE, IFNG, CCL2
36	positive regulation of isotype switching to IgG isotypes	GO:048304	9.5	IFNG, IL4, IL2
37	defense response to bacterium	GO:042742	9.5	LYZ, PRG2, LTF, RNASE3, IFNG
38	neutrophil chemotaxis	GO:030593	9.4	CXADR, IFNG, CCL2, IL8
39	response to drug	GO:042493	9.4	TGFB1, ABP1, NGF, ICAM1, IFNG, CCL5
40	blood coagulation	GO:007596	9.4	SLC7A5, CXADR, TGFB1, THPO, TIMP1, TMSB4X
41	cell-cell signaling	GO:007267	9.3	CCL17, CCL24, CCL5, CXCL11, CXCL9, CCL22
42	virus-host interaction	GO:019048	9.2	CXADR, TGFB1, MMP1, CD46, CD80, CD86
43	defense response to virus	GO:051607	9.2	CXCL9, CXADR, F2RL1, IFNG, CD86, RELA
44	cytokine-mediated signaling pathway	GO:019221	9.0	ICAM1, IFNG, CCL2, IL5, IL1A, VCAM1
45	positive regulation of cell proliferation	GO:008284	8.8	TGFB1, THPO, TIMP1, EGFR, NGF, IL3
46	signal transduction	GO:007165	8.8	CCL1, CCL24, EGFR, HBEGF, CXCL11, CXCL9
47	inflammatory response	GO:006954	8.7	CXCL9, CXCL11, TGFB1, NGF, F2RL1, CCL5
48	cell adhesion	GO:007155	8.5	CXCR3, ICAM1, CCL11, CCL2, IL2, CD4
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.8	TGFB1, SMAD2, AIRE, F2RL1, IFNG, IL4
50	immune response	GO:006955	7.8	VIPR1, CCL22, CCL7, CCL8, IL8, IL5

Molecular functions related to keratoconjunctivitis according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	integrin binding	GO:005178	10.0	VCAM1, ITGA6, ICAM1, ICAM3, TIMP2
2	metalloendopeptidase activity	GO:004222	9.8	PITRM1, MMP9, MMP8, MMP3, MMP13, MMP10
3	chemokine activity	GO:008009	9.6	IL8, CXCL9, CXCL11, CCL5, CCL24, CCL1
4	heparin binding	GO:008201	9.4	LTF, ABP1, HBEGF, PRG2, CCL5, CCL2
5	growth factor activity	GO:008083	9.0	TGFB1, THPO, HBEGF, NGF, NRTN, IL5
6	cytokine activity	GO:005125	8.2	IL5, IFNG, TSLP, THPO, CXCL9, IL4
7	protein binding	GO:005515	4.8	AIRE, HSPG2, F2RL1, ICAM3, ICAM1, CCL5