MCID: KRT006
MIFTS: 52

Keratoconjunctivitis malady

Infectious, Eye categories

Summaries for Keratoconjunctivitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Keratoconjunctivitis is inflammation (\"-itis\") of the cornea and conjunctiva. more...

MalaCards: Keratoconjunctivitis, also known as certain types of keratoconjunctivitis, is related to keratoconjunctivitis sicca and vernal keratoconjunctivitis. An important gene associated with Keratoconjunctivitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Selected targets of GCR-alpha and OX40 Pathway. The drugs lodoxamide tromethamine and lodoxamide and the compounds pge2 and hydrocortisone have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and respiratory system.

Aliases & Classifications for Keratoconjunctivitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Eye


Aliases & Descriptions:

keratoconjunctivitis 8 10 45 61
certain types of keratoconjunctivitis 8


External Ids:

Disease Ontology8 DOID:9368
MeSH35 D007637
NCIt40 C34744
ICD9CM27 370.40
ICD1025 B30.0, H16.2

Related Diseases for Keratoconjunctivitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Keratoconjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 252)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis sicca31.7LTF, HSPG2
2vernal keratoconjunctivitis31.6VCAM1, CMA1, IL4, IL5, IL3, IL13
3allergic conjunctivitis30.5IL4, IL5, IL13, RNASE3, IGHE, CCL11
4arthritis30.4MMP1, MMP3, IL4, IL13, CXCL9, CXCR3
5atopic dermatitis30.3VCAM1, CMA1, IL4, IL5, IL13, CXCL9
6uveitis30.2IL4, CXCL9, CXCR3, CCL11
7sjogren's syndrome30.2CXCL9, CXCR3, LTF, HSPG2
8giant papillary conjunctivitis30.1IL5, RNASE3, LTF, CCL11
9graft versus host disease30.1IL4, IL3, IL13, CCL5
10atopy30.1CMA1, IL4, IL5, IL13, CXCR3, RNASE3
11erythema multiforme30.0HSPG2
12lichen planus30.0CXCL9, CXCR3
13asthma30.0IL13, CCL11
14stevens-johnson syndrome29.8HSPG2
15tuberculosis29.8IL4, CXCL9, CXCR3
16common variable immune deficiency29.8IL4
17allergic rhinitis29.8IL4, IL5, IL13, RNASE3, IGHE, CCL11
18allergic asthma29.8VCAM1, CMA1, IL4, IL5, IL3, IL13
19conjunctivochalasis29.8MMP1, MMP3
20atopic keratoconjunctivitis10.8
21superior limbic keratoconjunctivitis10.8
22vernal conjunctivitis10.4
23vernal keratitis10.2
24corneal disease10.2
25shipyard eye10.1
26rosacea10.1
27trachoma10.1
28punctate epithelial keratoconjunctivitis10.1
29neurotrophic keratoconjunctivitis10.1
30n syndrome10.1
31achalasia10.0
32exposure keratitis10.0
33phlyctenulosis10.0
34conjunctival pigmentation10.0
35acute conjunctivitis10.0
36amblyopia10.0
37sj�gren syndrome10.0
38adrenocortical insufficiency10.0
39acanthamoeba keratitis10.0
40peritonitis10.0CMA1
41crohn's disease10.0LTF
42ovarian cancer10.0IL3
43eosinophilic esophagitis10.0IL5, CCL11
44onchocerciasis10.0IL5, RNASE3
45purpura10.0HSPG2
46conjunctivitis10.0RNASE3, IGHE
47malaria10.0CXCL9, CCL5
48candidiasis10.0LTF
49hepatitis b10.0MMP3, LTF
50kawasaki disease10.0MMP3

Graphical network of the top 20 diseases related to Keratoconjunctivitis:



Diseases related to keratoconjunctivitis

Clinical Features for Keratoconjunctivitis

Drugs & Therapeutics for Keratoconjunctivitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Keratoconjunctivitis

Drug clinical trials:

Search ClinicalTrials for Keratoconjunctivitis

Search NIH Clinical Center for Keratoconjunctivitis

Search CenterWatch for Keratoconjunctivitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Keratoconjunctivitis

Anatomical Context for Keratoconjunctivitis

Animal Models for Keratoconjunctivitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Keratoconjunctivitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.1IL5, VCAM1, MMP3, IL4, HSPG2, IGHE
2MP:000538810.0CCL11, PRG2, CXCR3, CCL24
3MP:000539710.0HSPG2, CCL24, CCL11, CCL5, PRG2, IGHE
4MP:00053879.9VCAM1, HSPG2, CCL24, CCL11, CCL5, PRG2

Publications for Keratoconjunctivitis

Sources:
51PubMed
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Articles related to Keratoconjunctivitis:

(show top 50)    (show all 944)
idTitleAuthorsYear
1
Autoimmunity in the pathogenesis and treatment of keratoconjunctivitis sicca. (24395332)
2014
2
Dynamics of an infectious keratoconjunctivitis outbreak by Mycoplasma conjunctivae on Pyrenean Chamois Rupicapra p. pyrenaica. (23637923)
2013
3
Surveillance of adenovirus D in patients with epidemic keratoconjunctivitis from Fukui Prefecture, Japan, 1995-2010. (22052618)
2012
4
Prognostic factors for the clinical severity of keratoconjunctivitis sicca in patients with Sjogren's syndrome. (21558290)
2012
5
Tacrolimus ointment 0.03% for treatment of refractory childhood phlyctenular keratoconjunctivitis. (22525784)
2012
6
Randomized controlled field trial to assess efficacy of a Moraxella bovis pilin-cytotoxin-Moraxella bovoculi cytotoxin subunit vaccine to prevent naturally occurring infectious bovine keratoconjunctivitis. (23013196)
2012
7
Phototherapeutic keratectomy for the treatment of corneal opacities after epidemic keratoconjunctivitis. (21109229)
2011
8
Childhood chronic anterior uveitis associated with vernal keratoconjunctivitis (VKC): successful treatment with topical tacrolimus. Case series. (22047067)
2011
9
Aquarium coral keratoconjunctivitis. (20938008)
2010
10
Evaluation of eotaxin-1, -2, and -3 protein production and messenger RNA expression in patients with vernal keratoconjunctivitis. (19333691)
2009
11
RETRACTED: Spread of epidemic keratoconjunctivitis due to a novel serotype of human adenovirus in Japan. (19420171)
2009
12
Outbreak of gram-positive bacterial keratitis associated with epidemic keratoconjunctivitis in neonates and infants. (18670461)
2009
13
An outbreak of epidemic keratoconjunctivitis in a regional ophthalmology clinic in New South Wales. (18047749)
2008
14
Mathematical modelling of epidemics under specific regard of adenoviral keratoconjunctivitis. (18952517)
2008
15
Clinical course of epidemic keratoconjunctivitis: evaluation by in vivo confocal microscopy. (18362649)
2008
16
Superficial keratectomy and amniotic membrane patch in the treatment of corneal plaque of vernal keratoconjunctivitis. (18203099)
2008
17
Role of rigid gas-permeable scleral contact lenses in the management of advanced atopic keratoconjunctivitis. (17893528)
2007
18
Comparison of tobramycin 0.3%/dexamethasone 0.1% and tobramycin 0.3%/loteprednol 0.5% in the management of blepharo-keratoconjunctivitis. (17526462)
2007
19
Adenovirus transmission in a nursing home: analysis of an epidemic outbreak of keratoconjunctivitis. (17429213)
2007
20
Conjunctival Inclusion Cysts in Long-standing Chronic Vernal Keratoconjunctivitis. (18063892)
2007
21
Bilateral infectious ulcers associated with atopic keratoconjunctivitis. (16371796)
2006
22
Case series of 406 vernal keratoconjunctivitis patients: a demographic and epidemiological study. (16704708)
2006
23
Outbreaks of infectious keratoconjunctivitis in alpine chamois and ibex in Switzerland between 2001 and 2003. (15995237)
2005
24
Topical cyclosporine 0.5 per cent and preservative-free ketorolac tromethamine 0.5 per cent in vernal keratoconjunctivitis. (15061303)
2004
25
The T-lymphocyte chemoattractant Mig is highly expressed in vernal keratoconjunctivitis. (14597036)
2003
26
Atopy and serum eosinophil cationic protein in 110 white children with vernal keratoconjunctivitis: differences between tarsal and limbal forms. (12614446)
2003
27
Preservative-free diclofenac sodium 0.1% for vernal keratoconjunctivitis. (12644942)
2003
28
Expression of T lymphocyte chemoattractants and activation markers in vernal keratoconjunctivitis. (12234902)
2002
29
Supratarsal injection of corticosteroids in the treatment of refractory vernal keratoconjunctivitis. (12194580)
2002
30
Topical cyclosporine A (2%) eyedrops in the therapy of atopic keratoconjunctivitis and keratoconjunctivitis vernalis. (12613996)
2002
31
Haemophilus influenzae corneal ulcer associated with atopic keratoconjunctivitis and herpes simplex keratitis. (11914228)
2002
32
Chemokines in the limbal form of vernal keratoconjunctivitis. (11090473)
2000
33
Mechanisms and comparison of anti-allergic efficacy of topical lodoxamide and cromolyn sodium treatment in vernal keratoconjunctivitis. (10890862)
2000
34
Surgical resection of giant papillae and autologous conjunctival graft in patients with severe vernal keratoconjunctivitis and giant papillae. (11106188)
2000
35
Estrogen therapy in keratoconjunctivitis sicca. (9635003)
1998
36
Color discrimination in patients with keratoconjunctivitis sicca before and after artificial tear application. (9615962)
1998
37
Oral pilocarpine for symptomatic relief of keratoconjunctivitis sicca in patients with SjAPgren's syndrome. The MGI PHARMA SjAPgren's Syndrome Study Group. (9634998)
1998
38
Cellular immunity in dogs with keratoconjunctivitis sicca before and after treatment with topical 2% cyclosporine. (8746695)
1995
39
The role of eosinophil cationic protein (ECP) and histamine in vernal keratoconjunctivitis. (22827228)
1995
40
Efficacy of lodoxamide 0.1% ophthalmic solution in resolving corneal epitheliopathy associated with vernal keratoconjunctivitis. (8154531)
1994
41
Keratoconjunctivitis sicca in a patient with a Jones tube to treat sleep apnea. (1642310)
1992
42
Immunopathology of atopic keratoconjunctivitis. (1923355)
1991
43
Keratoconjunctivitis sicca with associated secondary uveitis elicited in rats after systemic xylazine/ketamine anesthesia. (2591501)
1989
44
Keratoconjunctivitis sicca and the treatment of canine colitis. (2878518)
1986
45
Vernal keratoconjunctivitis: new corneal findings in fraternal twins. (6571493)
1984-1985
46
Immunochemical determination of human tear lysozyme (muramidase) in keratoconjunctivitis sicca. (6807577)
1982
47
Keratoconjunctivitis sicca and epidermophyton infections. (550384)
1979
48
Histology of the lacrimal gland in keratoconjunctivitis sicca. (4785251)
1973
49
Keratoconjunctivitis sicca in sarcoidosis. (14418276)
1960
50
Congenital alacrimia and keratoconjunctivitis sicca in children. (13217790)
1954

Genetic Variations for Keratoconjunctivitis

Expression for genes affiliated with Keratoconjunctivitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Keratoconjunctivitis

Search GEO for disease gene expression data for Keratoconjunctivitis.

Pathways for genes affiliated with Keratoconjunctivitis

Sources:
12EMD Millipore, 52QIAGEN, 53R&D Systems, 30KEGG, 38NCBI BioSystems Database, 4Cell Signaling Technology, 54Reactome
See all sources

Pathways related to Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IL4, IL5, CCL11
210.4IL4, IL5, IL13
310.4IL13, IL5, IL4
410.4IL4, IL5, IL3
5
Hide members
10.4IL3, IL5, IL4
610.4IL13, IL3, IL5, IL4
710.4IL13, IL3, IL5, IL4
810.4CCL11, CXCR3, CXCL9
9
Cell adhesion ECM remodeling
Hide members
10.4CMA1, MMP1, MMP3
10
Cell adhesion Cell-matrix glycoconjugates
Hide members
10.4MMP1, MMP3, CCL5
1110.4IL13, IL5, IL4, MMP1
1210.4CCL11, IGHE, IL5, IL4
13
Hide members
10.4MMP1, MMP3, HSPG2
1410.3VCAM1, IL4, IL3, CCL5
15
Hide members
10.3HSPG2, MMP3, MMP1, CMA1
16
Hide members
10.3CCL11, IGHE, IL13, IL3, IL5, IL4
1710.3CCL22, CCL11, CCL5, CXCR3, CXCL9
18
Hide members
10.3CCL11, PRG2, RNASE3, IL13, IL3, IL5
19
Hide members
10.3CCL22, CCL24, CCL11, CCL5, CXCR3, CXCL9
20
Hide members
10.3HSPG2, CCL22, CCL24, PRG2, CXCR3, IL5
21
Hide members
10.2CCL22, CCL24, CCL11, CCL5, IL13, IL3
22
Hide members
10.2CCL22, CCL24, CCL11, CXCR3, CXCL9, IL13
23
Hide members
10.2IL5, IL3, IL13, CXCL9, CXCR3, CCL5
24
Hide members
10.2CCL22, IL4, IL5, IL3, IL13, CXCL9
25
Hide members
10.1HSPG2, CCL22, CCL11, CCL5, NGF, CXCR3
26
Hide members
10.1VCAM1, HSPG2, CCL22, CCL24, CCL11, CCL5

Compounds for genes affiliated with Keratoconjunctivitis

Sources:
45Novoseek, 2BitterDB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB
See all sources

Compounds related to Keratoconjunctivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 211)
idCompoundScoreTop Affiliating Genes
1pge24510.9CCL11
2hydrocortisone45 2 60 1113.8IGHE, LTF, MMP1
3rantes4510.8CCL11, RNASE3, CXCR3, IL3, IL4
4indomethacin45 60 29 1113.7HSPG2, PRG2, LTF, NGF, IL5
5salmeterol45 50 29 1113.7IL4, CCL11, IL5, IL13, RNASE3, CCL5
6fluticasone propionate45 50 60 1113.7CCL11, CCL5, VCAM1, IL4, IL5, IL13
7endotoxin4510.7LTF, RNASE3, VCAM1, CXCR3
8montelukast45 50 29 1113.7IL4, IL5, IL13, RNASE3, IGHE, CCL11
9allergens4510.6IL4, CMA1, PRG2, CCL11, IGHE, RNASE3
10leukotriene b445 60 2412.6IL13, RNASE3, LTF, CCL5, CCL11, CCL22
11ltc44510.6CCL11, IL13, RNASE3, IL3, PRG2, IL5
12il 104510.6IL4, IL13, CXCL9, IL3, IL5, CCL5
13cycloheximide4510.6HSPG2
14sodium cromoglycate4510.6VCAM1, CCL11, IGHE, RNASE3, IL5
15cyclosporin a45 29 6012.6CCL22, CCL11, CCL5, IGHE, LTF, NGF
16prednisolone45 29 1112.6VCAM1, CCL11, IGHE, NGF, RNASE3, IL13
17budesonide45 50 1112.6IL13, RNASE3, LTF, IGHE, CCL5, CCL11
18dexamethasone45 50 29 1113.6LTF, RNASE3, IL13, IL3, IL5, IGHE
19capsaicin45 2911.6IGHE, HSPG2, LTF, RNASE3, IL5, CMA1
20ccl345 2911.6CCL11, CXCL9, CXCR3, CCL5, IL13, CCL22
21fmlp4510.6LTF, CCL11, PRG2, HSPG2, RNASE3, VCAM1
22methacholine45 1111.6CCL5, PRG2, IGHE, LTF, RNASE3, IL13
23groalpha4510.6CXCL9, IL13, VCAM1, CXCR3, CCL5, CCL11
24tarc4510.6IL4, IL5, IL13, CXCL9, CXCR3, IGHE
25aspirin45 50 29 2413.6HSPG2, CCL22, IL4, MMP1, IL13, RNASE3
26herbimycin a45 6011.6VCAM1, MMP1, HSPG2, IL4, IL3, NGF
27sb 20358045 6011.6IL5, IL13, IL4, NGF, CCL5, MMP3
28nedocromil sodium4510.6RNASE3, IGHE, IL4, IL5, IL3
29salbutamol45 50 29 11 2414.6IGHE, VCAM1, IL5, IL13, RNASE3, CCL11
30ly2940024510.6IL4, IL5, IL3, IL13, CXCR3, NGF
31n acetylcysteine4510.5CCL5, LTF, RNASE3, IL4, MMP3, VCAM1
32tacrolimus45 50 1112.5IL13, IL3, IL4, IL5, CCL22, CCL11
33heparin45 29 11 2413.5LTF, RNASE3, CXCR3, MMP3, CMA1, VCAM1
34adenylate4510.5VCAM1, IL13, IL3, IL4, RNASE3, NGF
35genistein45 29 60 2 11 2415.5MMP3, HSPG2, CCL11, CCL5, NGF, IL5
36pranlukast45 29 1112.5CCL5, CCL11, RNASE3, IL5, IL4
37pgd24510.4IL5, CCL11, PRG2, IGHE, RNASE3, IL13
38creatinine4510.4NGF, RNASE3, IGHE, CXCR3, CXCL9, IL3
39retinoic acid45 2411.4CCL11, CCL5, PRG2, IGHE, LTF, NGF
40pd 98,0594510.4HSPG2, CCL5, VCAM1, IL3, NGF, CXCR3
41vegf4510.4HSPG2, CCL11, CCL5, VCAM1, IGHE, LTF
42cysteine4510.4IL5, PRG2, LTF, IL13, IL3, CCL5
43actinomycin d4510.3IL4, IGHE, IL3, IL13, LTF, PRG2
44azelastine45 1111.3IL3, IL5, RNASE3, IGHE, IL4
45pertussis4510.3HSPG2, CCL11, CCL5, IGHE, LTF, CCL22
46tyrosine4510.3PRG2, CXCL9, CXCR3, RNASE3, NGF, IL3
47poly(i-c)4510.3VCAM1, IL4, IL5, IL3, CCL5, CCL11
48histamine45 29 2412.3HSPG2, IL3, IL5, IL4, MMP3, CMA1
49praziquantel45 1111.2RNASE3, IL13, IGHE, IL5, IL4
50n-formylmethionyl-leucylphenylalanine4510.0IL5, HSPG2, CCL11, LTF, IL3, RNASE3

GO Terms for genes affiliated with Keratoconjunctivitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.3VCAM1, IL4, IL13, CXCL9, CXCR3
2extracellular regionGO:0055769.8CMA1, HSPG2, CCL22, CCL11, CCL5, PRG2
3extracellular spaceGO:0056159.7HSPG2, CCL22, CCL24, CCL11, CCL5, NGF

Biological processes related to Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:03089010.6IL13, IL5, IL4
2eosinophil chemotaxisGO:04824510.6CCL24, CCL11, CCL5
3regulation of proton transportGO:01015510.6IL13, IL4
4positive regulation of T cell proliferationGO:04210210.6IL4, VCAM1, CCL5
5chronic inflammatory responseGO:00254410.5CCL11, VCAM1
6cell-cell signalingGO:00726710.5CCL5, CCL22, CCL24, CXCL9, IL13, IL3
7chemotaxisGO:00693510.5CCL11, CXCL9, CXCR3, CCL5, CCL24, CCL22
8positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.5IL4, IL5, NGF
9inflammatory responseGO:00695410.5CCL24, CCL22, CCL5, CCL11, NGF, CXCR3
10positive regulation of JAK-STAT cascadeGO:04642710.4CCL5, IL5
11immune responseGO:00695510.4IL13, IL5, IL3, CXCL9, IGHE, PRG2
12extracellular matrix disassemblyGO:02261710.4CMA1, MMP1, MMP3
13positive regulation of angiogenesisGO:04576610.3CCL24, CCL11, CMA1
14extracellular matrix organizationGO:03019810.0HSPG2, MMP3, MMP1, CMA1

Molecular functions related to Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00808310.4IL4, IL5, IL3, NGF
2chemokine activityGO:00800910.2CXCL9, CCL5, CCL11, CCL24, CCL22
3cytokine activityGO:00512510.0CXCL9, IL13, IL3, IL5, IL4

Products for genes affiliated with Keratoconjunctivitis

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  • Proteins
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Sources for Keratoconjunctivitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet