MCID: KRT006
MIFTS: 48

Keratoconjunctivitis malady

Infectious diseases, Eye diseases categories

Summaries for Keratoconjunctivitis

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Wikipedia:63 Keratoconjunctivitis is inflammation (\"-itis\") of the cornea and conjunctiva. more...

MalaCards based summary: Keratoconjunctivitis, also known as certain types of keratoconjunctivitis, is related to conjunctivitis and corneal ulcer. An important gene associated with Keratoconjunctivitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Inflammatory Response Pathway and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions. The drugs lodoxamide tromethamine and lodoxamide and the compounds unicap and omalizumab have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related mouse phenotypes are respiratory system and immune system.

Aliases & Classifications for Keratoconjunctivitis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 27ICD9CM, 38NCIt, 33MeSH, 25ICD10
See all sources

Keratoconjunctivitis, Aliases & Descriptions:

Name: Keratoconjunctivitis 9 11 43 60
 
Certain Types of Keratoconjunctivitis 9 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology9 DOID:9368
ICD9CM27 370.40
NCIt38 C34744
MeSH33 D007637
ICD1025 B30.0, H16.2

Related Diseases for Keratoconjunctivitis

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Diseases related to Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1conjunctivitis31.5RNASE3
2corneal ulcer30.9CCL11, NGF
3uveitis30.5IL4, CCL11
4giant papillary conjunctivitis30.5RNASE3, CCL11, IL5
5asthma30.4IL13, CCL11
6allergic conjunctivitis30.3IL13, IL5, IL4, CCL11, RNASE3
7esophagitis30.3IL13, IL5, CCL11
8rheumatoid arthritis30.3IL13, IL4, CCL11, RNASE3
9otitis media30.2RNASE3, CCL11
10vernal keratoconjunctivitis30.2NGF, IL13, IL3, IL5, IL4, CCL11
11dermatitis30.1RNASE3, CMA1, IL4, IL13
12colitis30.1NGF, IL4, IL13
13pneumonia30.0CCL22, CCL11, IL5, IL13
14allergic rhinitis29.8RNASE3, IL4, IL5, IL13
15atopic dermatitis29.6NGF, RNASE3, CCL22, CCL11, IL4, IL13
16eosinophilia29.1RNASE3, NGF, CCL11, IL4, IL13, IL3
17atopy29.1IL13, IL5, IL4, CCL11, CCL22, CMA1
18rhinitis29.1RNASE3, IL13, IL5, IL4, CCL11, CMA1
19allergic asthma28.3IL13, IL3, IL5, IL4, CCL11, CMA1
20keratoconjunctivitis sicca11.1
21atopic keratoconjunctivitis10.8
22superior limbic keratoconjunctivitis10.8
23folliculitis10.5CCL11
24keratitis10.5
25paragonimiasis10.5IL5
26strongyloidiasis10.4IL5
27keratoconus10.4
28blindness10.4
29esophagitis, eosinophilic, 110.4IL5, CCL11
30cystitis10.4NGF
31urticaria10.3RNASE3
32eosinophilic gastroenteritis10.3CCL11, IL5
33kimura disease10.3RNASE3, IL5
34egg allergy10.3IL4, IL5
35allergic bronchopulmonary aspergillosis10.3IL5, IL4
36sjogren's syndrome10.3
37onchocerciasis10.3RNASE3, IL5
38schistosomiasis10.3IL5, IL13
39churg-strauss syndrome10.3RNASE3, IL5
40hyper-ige recurrent infection syndrome10.3RNASE3, IL4
41common cold10.3RNASE3, CCL11
42arthritis10.3
43omenn syndrome10.3IL5, IL4
44filariasis10.3IL13, IL5
45sezary's disease10.2IL5, IL4
46shipyard eye10.2
47angioedema10.2IL5, RNASE3
48sinusitis10.2RNASE3, CCL11, IL5
49chronic eosinophilic pneumonia10.2RNASE3, CCL11, IL5
50severe combined immunodeficiency, x-linked10.2IL13, IL4

Graphical network of the top 20 diseases related to Keratoconjunctivitis:



Diseases related to keratoconjunctivitis

Symptoms for Keratoconjunctivitis

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Drugs & Therapeutics for Keratoconjunctivitis

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Drug clinical trials:

Search ClinicalTrials for Keratoconjunctivitis

Search NIH Clinical Center for Keratoconjunctivitis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Keratoconjunctivitis

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Anatomical Context for Keratoconjunctivitis

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MalaCards organs/tissues related to Keratoconjunctivitis:

31
Eye, Testes, T cells, Bone, Salivary gland, Bone marrow, Thyroid, B cells, Neutrophil

Animal Models for Keratoconjunctivitis or affiliated genes

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MGI Mouse Phenotypes related to Keratoconjunctivitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.3IL13, IL3, IL5, IL4, CCL11
2MP:00053877.5IL13, IL3, IL5, IL4, CCL11, CMA1
3MP:00053977.2CMA1, CCL11, IL4, IL5, IL3, IL13

Publications for Keratoconjunctivitis

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Articles related to Keratoconjunctivitis:

(show top 50)    (show all 982)
idTitleAuthorsYear
1
Microvascular autologous submandibular gland transplantation in severe cases of keratoconjunctivitis sicca. (25664315)
2015
2
Evaluation of the impact of persistent subepithelial corneal infiltrations on the visual performance and corneal optical quality after epidemic keratoconjunctivitis. (25043311)
2014
3
The Role of Chlamydia Pneumoniae in the Etiology Keratoconjunctivitis Sicca (KCS). (25395268)
2014
4
Increased incidence of thyroid dysfunction and autoimmunity in patients with vernal keratoconjunctivitis. (25140177)
2014
5
Epidemic adenoviral keratoconjunctivitis complicated by massive bilateral lower eyelid cysts. (24398504)
2014
6
Surgical resection and amniotic membrane transplantation for treatment of refractory giant papillae in vernal keratoconjunctivitis. (23086371)
2013
7
Superior limbic keratoconjunctivitis causing chronic ocular irritation in a child. (23791418)
2013
8
Management of vernal keratoconjunctivitis. (25135808)
2013
9
Surgical treatment of 32 cases of long-term atopic keratoconjunctivitis using the amniotic membrane. (23949491)
2013
10
Corneal sequestrum in a dog with chronic unilateral keratoconjunctivitis sicca. (24299547)
2013
11
Topical calcineurin inhibitors in the treatment of steroid-dependent atopic keratoconjunctivitis. (22378107)
2012
12
Evaluation of cytokines as adjuvants of infectious bovine keratoconjunctivitis vaccines. (22264735)
2012
13
Occurrence, quantification, and genotyping of Mycoplasma conjunctivae in wild Caprinae with and without infectious keratoconjunctivitis. (22740528)
2012
14
Superior limbic keratoconjunctivitis causing chronic ocular irritation in a child. (23158547)
2012
15
Acute haemorrhagic conjunctivitis epidemics and outbreaks of Paederus spp. keratoconjunctivitis ('Nairobi red eyes') and dermatitis. (21920128)
2011
16
Ocular surface disease: a case of vernal keratoconjunctivitis. (20971677)
2011
17
Association of toll-like receptor four single nucleotide polymorphisms with incidence of infectious bovine keratoconjunctivitis (IBK) in cattle. (20938658)
2011
18
Systemic cyclosporin A in severe atopic keratoconjunctivitis. (20491051)
2010
19
Possible unilateral ultraviolet keratoconjunctivitis during an expedition-length desert race. (20591383)
2010
20
Conjunctival impression cytology for the diagnosis, follow-up, and treatment in a patient with severe keratoconjunctivitis caused by alkali injury. (19574901)
2009
21
Keratoconjunctivitis associated with Toxoplasma gondii in a dog. (19152600)
2009
22
Corneal in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. (18584874)
2008
23
Vaccine against infectious bovine keratoconjunctivitis: a new approach to optimize the production of highly piliated Moraxella bovis cells. (18852003)
2008
24
Natural killer cells in vernal keratoconjunctivitis. (17893656)
2007
25
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)
2006
26
Topical cyclosporine A in severe steroid-dependent childhood phlyctenular keratoconjunctivitis. (16386977)
2006
27
Effect of cyclosporin A eye drop on keratoconjunctivitis sicca and its mechanism. (16696343)
2005
28
Prevention of naturally occurring infectious bovine keratoconjunctivitis with a recombinant Moraxella bovis cytotoxin-ISCOM matrix adjuvanted vaccine. (15530703)
2004
29
Rapid and sensitive diagnosis of adenoviral keratoconjunctivitis by loop-mediated isothermal amplification (LAMP) method. (15590466)
2004
30
Tumor necrosis factor-alpha (TNF-alpha) in seasonal allergic conjunctivitis and vernal keratoconjunctivitis. (14552593)
2003
31
The T-lymphocyte chemoattractant Mig is highly expressed in vernal keratoconjunctivitis. (14597036)
2003
32
Videokeratography findings in children with vernal keratoconjunctivitis versus those of healthy children. (12414408)
2002
33
Active matrix metalloproteinases in the tear fluid of individuals with vernal keratoconjunctivitis. (12209100)
2002
34
Histologic characteristics and local cellular immunity of the gland of the third eyelid after topical ophthalmic administration of 2% cyclosporine for treatment of dogs with keratoconjunctivitis sicca. (12013470)
2002
35
Nedocromil sodium eye drops are more effective than sodium cromoglycate eye drops for the long-term management of vernal keratoconjunctivitis. (10202368)
1999
36
Vernal keratoconjunctivitis in a Stockholm ophthalmic centre--epidemiological, functional, and immunologic investigations. (10551301)
1999
37
Estrogen therapy in keratoconjunctivitis sicca. (9635003)
1998
38
The association of conjunctival snake-like chromatin with keratoconjunctivitis SICCA. (9891892)
1998
39
Lodoxamide in vernal keratoconjunctivitis. (8740338)
1996
40
Increased serum levels of eosinophil cationic protein and eosinophil-derived neurotoxin (protein X) in vernal keratoconjunctivitis. (7800361)
1994
41
Atopic keratoconjunctivitis. (22823113)
1994
42
Efficacy and safety of lodoxamide 0.1% vs cromolyn sodium 4% in patients with vernal keratoconjunctivitis. (1598953)
1992
43
Keratoconjunctivitis sicca and diabetes mellitus in a dog. (1639704)
1992
44
Unpreserved carboxymethylcellulose artificial tears evaluated in patients with keratoconjunctivitis sicca. (1424648)
1992
45
Acute dacryocystitis after punctal occlusion of keratoconjunctivitis sicca. (2039051)
1991
46
A new perspective on canine keratoconjunctivitis sicca. Treatment with ophthalmic cyclosporine. (2194349)
1990
47
Keratoconjunctivitis sicca associated with fracture of the stylohyoid bone in a horse. (2917892)
1989
48
Superior limbic keratoconjunctivitis (SLK). (2695351)
1989
49
Limbal vernal keratoconjunctivitis with a hypertrophic limbal mass lesion. (3566030)
1987
50
Keratoconjunctivitis sicca and the treatment of canine colitis. (2878518)
1986

Variations for Keratoconjunctivitis

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Expression for genes affiliated with Keratoconjunctivitis

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Search GEO for disease gene expression data for Keratoconjunctivitis.

Pathways for genes affiliated with Keratoconjunctivitis

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Pathways related to Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL5, IL4
2
Show member pathways
9.6CCL11, CCL22
39.4CCL11, IL4, IL5
49.3IL4, IL5, IL13
59.3IL4, IL5, IL13
6
Show member pathways
9.3IL4, IL5, IL13
79.3IL13, IL5, IL4
89.3IL13, IL5, IL4
99.1IL3, IL5, IL4
10
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.1IL3, IL5, IL4
119.0IL3, IL4, NGF
12
Show member pathways
Type III interferon signaling36
8.7IL4, IL5, IL3, IL13
13
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
8.7IL4, IL5, IL3, IL13
148.7IL4, IL5, IL3, IL13
15
Show member pathways
7.9IL13, IL3, IL5, IL4, CCL11, RNASE3
16
Show member pathways
7.8CCL22, CCL11, IL4, IL5, IL3, IL13
17
Show member pathways
7.8CCL22, CCL11, IL4, IL5, IL3, IL13
18
Show member pathways
7.8CCL22, CCL11, IL4, IL5, IL3, IL13
19
Show member pathways
7.8CCL22, CCL11, IL4, IL5, IL3, IL13
20
Show member pathways
7.8CCL22, CCL11, IL4, IL5, IL3, IL13

Compounds for genes affiliated with Keratoconjunctivitis

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Compounds related to Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1unicap439.7IL5, RNASE3, CCL11
2omalizumab43 1210.6IL13, IL5, IL4
3lte4439.5IL5, CCL11, RNASE3
4sodium cromoglycate439.5CCL11, RNASE3, IL5
5ovomucoid439.5IL13, IL4, IL5
6pranlukast43 28 1211.4IL4, IL5, CCL11, RNASE3
7formoterol43 28 1211.3IL13, RNASE3, IL4
8cetirizine43 28 24 1212.3CCL11, RNASE3, IL5
9rolipram43 59 2811.3IL13, CCL11, IL5, IL4
10salbutamol43 49 28 24 1213.3RNASE3, IL5, IL13, CCL11
11praziquantel43 1210.3IL4, RNASE3, IL5, IL13
12pgd2439.3CCL11, IL5, RNASE3, IL13
13nedocromil sodium439.1IL5, RNASE3, IL4, IL3
14azelastine43 1210.1IL4, RNASE3, IL3, IL5
15poly(i-c)439.1IL3, IL5, IL4, CCL11
16gm-csf43 2810.0IL4, IL5, IL3, IL13
17n-formylmethionyl-leucylphenylalanine439.0CCL11, IL5, RNASE3, IL3
18ltd4439.0IL13, IL3, RNASE3, IL5
19mip 1alpha439.0IL13, IL4, IL3
20salmeterol43 49 28 1212.0IL13, RNASE3, CCL11, IL4, IL5
21montelukast43 49 28 1212.0RNASE3, IL13, CCL11, IL5, IL4
22budesonide43 49 1211.0RNASE3, IL4, IL13, IL5, CCL11
23fluticasone propionate43 49 59 1212.0CCL11, RNASE3, IL13, IL5, IL4
24il 10438.9IL4, IL13, IL3, IL5
25theophylline43 28 24 1211.9IL5, RNASE3, IL13, NGF
26tarc438.9CCL22, IL13, IL5, CCL11, IL4
27prednisolone43 28 1210.8IL13, NGF, IL5, CCL11, RNASE3
28ltc4438.8RNASE3, CCL11, IL5, IL3, IL13
29ionomycin438.7CCL11, IL5, IL13, IL3, IL4
30indomethacin43 28 59 1211.7IL13, IL4, CCL11, NGF, IL5
31herbimycin a43 599.7IL3, NGF, CCL11, IL4, IL5
32fmlp438.7RNASE3, IL13, IL3, IL5, CCL11
33capsaicin43 289.6CMA1, IL5, RNASE3, NGF
34methacholine43 49 1210.5IL5, CCL22, CCL11, RNASE3, IL4, IL13
35pge2438.4CCL22, IL13, IL5, IL4, CCL11, RNASE3
36sb 20358043 599.3NGF, CCL22, CCL11, IL4, IL13, IL5
37aspirin43 49 28 2411.3NGF, RNASE3, CCL22, CCL11, IL4, IL13
38tacrolimus43 49 1210.3CCL22, IL4, IL3, IL5, IL13, CCL11
39leukotriene b443 59 2410.2IL3, CCL11, IL5, IL13, CCL22, RNASE3
40ly294002438.2NGF, IL5, IL4, IL13, IL3, CCL11
41allergens438.2RNASE3, CCL11, CMA1, IL13, IL4, IL5
42thymidine43 249.2CCL11, IL4, IL3, IL5, IL13, NGF
43vegf438.0IL4, NGF, RNASE3, CCL11, IL5, IL13
44actinomycin d437.9IL3, IL4, IL13, CCL11, NGF
45rantes437.9IL5, CCL22, IL4, IL3, CCL11, RNASE3
46heparin43 28 24 1210.8RNASE3, CMA1, CCL11, IL5, IL13, IL3
47adenylate437.6NGF, RNASE3, IL13, IL3, IL5, IL4
48cyclosporin a43 28 599.4IL4, IL5, IL3, CCL11, IL13, CCL22
49dexamethasone43 49 28 1210.3NGF, IL13, RNASE3, CCL22, CCL11, IL4
50histamine43 28 248.5IL3, RNASE3, CMA1, CCL22, CCL11, NGF

GO Terms for genes affiliated with Keratoconjunctivitis

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Cellular components related to Keratoconjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.3CCL22, CCL11, IL4, IL5, IL3, IL13
2extracellular regionGO:00055766.2IL13, NGF, RNASE3, CMA1, CCL22, CCL11

Biological processes related to Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1regulation of proton transportGO:00101559.8IL13, IL4
2response to radiationGO:00093149.6NGF, CCL11
3positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.6IL3, IL4
4response to nicotineGO:00350949.6NGF, IL13
5positive regulation of B cell proliferationGO:00308909.5IL13, IL5, IL4
6positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.5IL3, IL5
7positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.4NGF, IL4, IL5
8chemotaxisGO:00069359.4IL4, CCL11, CCL22
9extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.3IL4, NGF
10cell-cell signalingGO:00072678.8IL13, IL3, CCL22
11inflammatory responseGO:00069548.5NGF, CCL22, CCL11, IL5, IL13
12immune responseGO:00069558.1IL13, IL3, IL5, IL4, CCL11, CCL22

Molecular functions related to Keratoconjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00080099.6CCL11, CCL22
2growth factor activityGO:00080838.5IL3, IL5, IL4, NGF
3cytokine activityGO:00051258.4IL4, IL5, IL3, IL13

Products for genes affiliated with Keratoconjunctivitis

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Sources for Keratoconjunctivitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet