MCID: KRT006
MIFTS: 56

Keratoconjunctivitis malady

Infectious diseases, Eye diseases categories
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Summaries for Keratoconjunctivitis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Keratoconjunctivitis is inflammation (\"-itis\") of the cornea and conjunctiva. more...

MalaCards: Keratoconjunctivitis, also known as certain types of keratoconjunctivitis, is related to vernal keratoconjunctivitis and conjunctivitis. An important gene associated with Keratoconjunctivitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Inflammatory Response Pathway and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions. The drugs lodoxamide tromethamine and lodoxamide and the compounds unicap and omalizumab have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related mouse phenotypes are respiratory system and immune system.

Aliases & Classifications for Keratoconjunctivitis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
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Related Diseases for Keratoconjunctivitis

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17GeneCards, 18GeneDecks
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Diseases related to Keratoconjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1vernal keratoconjunctivitis31.3NGF, IL13, IL3, IL5, IL4, CCL11
2conjunctivitis30.9RNASE3
3corneal ulcer30.6CCL11, NGF
4allergic conjunctivitis30.4IL13, IL5, IL4, CCL11, RNASE3
5rheumatoid arthritis30.4IL13, IL4, CCL11, RNASE3
6uveitis30.3IL4, CCL11
7dermatitis30.2IL5, IL4, CCL11, CCL22, CMA1, IL13
8giant papillary conjunctivitis30.2RNASE3, CCL11, IL5
9graft versus host disease30.2IL13, IL3, IL4
10asthma30.1IL13, CCL11
11atopic dermatitis30.1NGF, RNASE3, CCL22, CCL11, IL4, IL13
12esophagitis30.1IL13, IL5, CCL11
13atopy29.9IL13, IL5, IL4, CCL11, CCL22, CMA1
14otitis media29.9RNASE3, CCL11
15eosinophilia29.8RNASE3, NGF, CCL11, IL4, IL13, IL3
16pneumonia29.8CCL22, CCL11, IL5, IL13
17allergic rhinitis29.7NGF, RNASE3, CCL11, IL4, IL5, IL13
18rhinitis29.6RNASE3, IL13, IL5, IL4, CCL11, CMA1
19allergic asthma29.4IL13, IL3, IL5, IL4, CCL11, CMA1
20keratoconjunctivitis sicca11.1
21atopic keratoconjunctivitis10.8
22superior limbic keratoconjunctivitis10.8
23keratitis10.5
24keratoconus10.4
25blindness10.3
26sjogren's syndrome10.3
27arthritis10.3
28st. louis encephalitis10.2
29shipyard eye10.2
30dacryoadenitis10.2
31encephalitis10.2
32papillary conjunctivitis10.2
33folliculitis10.1CCL11
34paragonimiasis10.1IL5
35corneal disease10.1
36rosacea10.1
37punctate epithelial keratoconjunctivitis10.1
38neurotrophic keratoconjunctivitis10.1
39eye disease10.1
40strongyloidiasis10.1IL5
41eosinophilic esophagitis10.1IL5, CCL11
42cystitis10.1NGF
43urticaria10.1RNASE3
44eosinophilic gastroenteritis10.1CCL11, IL5
45kimura disease10.1RNASE3, IL5
46egg allergy10.1IL4, IL5
47allergic bronchopulmonary aspergillosis10.1IL5, IL4
48onchocerciasis10.1RNASE3, IL5
49churg-strauss syndrome10.1RNASE3, IL5
50autosomal dominant hyper ige syndrome10.1RNASE3, IL4

Graphical network of the top 20 diseases related to Keratoconjunctivitis:



Diseases related to keratoconjunctivitis

Symptoms for Keratoconjunctivitis

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Drugs & Therapeutics for Keratoconjunctivitis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Keratoconjunctivitis

Search NIH Clinical Center for Keratoconjunctivitis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Keratoconjunctivitis

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Anatomical Context for Keratoconjunctivitis

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33MalaCards
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MalaCards organs/tissues related to Keratoconjunctivitis:

33
Eye, Testes, T cells, Bone, Salivary gland, Bone marrow, Thyroid, B cells

Animal Models for Keratoconjunctivitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Keratoconjunctivitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.3IL13, IL3, IL5, IL4, CCL11
2MP:00053877.5CMA1, CCL11, IL5, IL3, IL13, IL4
3MP:00053977.2IL3, IL5, IL4, CCL11, IL13, CMA1

Publications for Keratoconjunctivitis

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52PubMed
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Articles related to Keratoconjunctivitis:

(show top 50)    (show all 929)
idTitleAuthorsYear
1
Epidemic adenoviral keratoconjunctivitis complicated by massive bilateral lower eyelid cysts. (24398504)
2014
2
Superior limbic keratoconjunctivitis causing chronic ocular irritation in a child. (23791418)
2013
3
Surgical treatment of 32 cases of long-term atopic keratoconjunctivitis using the amniotic membrane. (23949491)
2013
4
Corneal sequestrum in a dog with chronic unilateral keratoconjunctivitis sicca. (24299547)
2013
5
Changes in sensory activity of ocular surface sensory nerves during allergic keratoconjunctivitis. (23867735)
2013
6
Topical calcineurin inhibitors in the treatment of steroid-dependent atopic keratoconjunctivitis. (22378107)
2012
7
Evaluation of cytokines as adjuvants of infectious bovine keratoconjunctivitis vaccines. (22264735)
2012
8
Occurrence, quantification, and genotyping of Mycoplasma conjunctivae in wild Caprinae with and without infectious keratoconjunctivitis. (22740528)
2012
9
Superior limbic keratoconjunctivitis causing chronic ocular irritation in a child. (23158547)
2012
10
Chronic keratoconjunctivitis with dermatitis as a presenting sign of child abuse. (22525179)
2012
11
Acute haemorrhagic conjunctivitis epidemics and outbreaks of Paederus spp. keratoconjunctivitis ('Nairobi red eyes') and dermatitis. (21920128)
2011
12
Ocular surface disease: a case of vernal keratoconjunctivitis. (20971677)
2011
13
Association of toll-like receptor four single nucleotide polymorphisms with incidence of infectious bovine keratoconjunctivitis (IBK) in cattle. (20938658)
2011
14
Phototherapeutic keratectomy for the treatment of corneal opacities after epidemic keratoconjunctivitis. (21109229)
2011
15
Systemic cyclosporin A in severe atopic keratoconjunctivitis. (20491051)
2010
16
Possible unilateral ultraviolet keratoconjunctivitis during an expedition-length desert race. (20591383)
2010
17
Conjunctival impression cytology for the diagnosis, follow-up, and treatment in a patient with severe keratoconjunctivitis caused by alkali injury. (19574901)
2009
18
Keratoconjunctivitis associated with Toxoplasma gondii in a dog. (19152600)
2009
19
Nucleotide sequence variation in the hexon gene of human adenovirus type 8 and 37 strains from epidemic keratoconjunctivitis patients in Japan. (19458172)
2009
20
The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca. (19668545)
2009
21
Corneal in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. (18584874)
2008
22
Vaccine against infectious bovine keratoconjunctivitis: a new approach to optimize the production of highly piliated Moraxella bovis cells. (18852003)
2008
23
Natural killer cells in vernal keratoconjunctivitis. (17893656)
2007
24
Conjunctival in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. (17768384)
2007
25
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)
2006
26
Topical cyclosporine A in severe steroid-dependent childhood phlyctenular keratoconjunctivitis. (16386977)
2006
27
Effect of cyclosporin A eye drop on keratoconjunctivitis sicca and its mechanism. (16696343)
2005
28
Prevention of naturally occurring infectious bovine keratoconjunctivitis with a recombinant Moraxella bovis cytotoxin-ISCOM matrix adjuvanted vaccine. (15530703)
2004
29
Rapid and sensitive diagnosis of adenoviral keratoconjunctivitis by loop-mediated isothermal amplification (LAMP) method. (15590466)
2004
30
Tumor necrosis factor-alpha (TNF-alpha) in seasonal allergic conjunctivitis and vernal keratoconjunctivitis. (14552593)
2003
31
The T-lymphocyte chemoattractant Mig is highly expressed in vernal keratoconjunctivitis. (14597036)
2003
32
Videokeratography findings in children with vernal keratoconjunctivitis versus those of healthy children. (12414408)
2002
33
Active matrix metalloproteinases in the tear fluid of individuals with vernal keratoconjunctivitis. (12209100)
2002
34
Histologic characteristics and local cellular immunity of the gland of the third eyelid after topical ophthalmic administration of 2% cyclosporine for treatment of dogs with keratoconjunctivitis sicca. (12013470)
2002
35
Nedocromil sodium eye drops are more effective than sodium cromoglycate eye drops for the long-term management of vernal keratoconjunctivitis. (10202368)
1999
36
Vernal keratoconjunctivitis in a Stockholm ophthalmic centre--epidemiological, functional, and immunologic investigations. (10551301)
1999
37
Estrogen therapy in keratoconjunctivitis sicca. (9635003)
1998
38
The association of conjunctival snake-like chromatin with keratoconjunctivitis SICCA. (9891892)
1998
39
Lodoxamide in vernal keratoconjunctivitis. (8740338)
1996
40
Increased serum levels of eosinophil cationic protein and eosinophil-derived neurotoxin (protein X) in vernal keratoconjunctivitis. (7800361)
1994
41
Atopic keratoconjunctivitis. (22823113)
1994
42
Efficacy and safety of lodoxamide 0.1% vs cromolyn sodium 4% in patients with vernal keratoconjunctivitis. (1598953)
1992
43
Keratoconjunctivitis sicca and diabetes mellitus in a dog. (1639704)
1992
44
Unpreserved carboxymethylcellulose artificial tears evaluated in patients with keratoconjunctivitis sicca. (1424648)
1992
45
Acute dacryocystitis after punctal occlusion of keratoconjunctivitis sicca. (2039051)
1991
46
A new perspective on canine keratoconjunctivitis sicca. Treatment with ophthalmic cyclosporine. (2194349)
1990
47
Keratoconjunctivitis sicca associated with fracture of the stylohyoid bone in a horse. (2917892)
1989
48
Superior limbic keratoconjunctivitis (SLK). (2695351)
1989
49
Limbal vernal keratoconjunctivitis with a hypertrophic limbal mass lesion. (3566030)
1987
50
Keratoconjunctivitis sicca and the treatment of canine colitis. (2878518)
1986

Variations for Keratoconjunctivitis

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Expression for genes affiliated with Keratoconjunctivitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratoconjunctivitis

Search GEO for disease gene expression data for Keratoconjunctivitis.

Pathways for genes affiliated with Keratoconjunctivitis

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50PathCards, 38NCBI BioSystems Database, 54R&D Systems, 55Reactome, 12EMD Millipore, 53QIAGEN, 30KEGG, 60Thomson Reuters
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Pathways related to Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL5, IL4
2
Show member pathways
9.6CCL11, CCL22
39.4CCL11, IL4, IL5
49.4CCL11, IL4, IL5
59.3IL4, IL5, IL13
69.3IL4, IL5, IL13
7
Show member pathways
9.3IL4, IL5, IL13
89.3IL13, IL5, IL4
99.3IL13, IL5, IL4
109.1IL3, IL5, IL4
11
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.1IL3, IL5, IL4
129.0IL3, IL4, NGF
13
Show member pathways
Type III interferon signaling38
8.7IL4, IL5, IL3, IL13
14
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
8.7IL4, IL5, IL3, IL13
158.7IL4, IL5, IL3, IL13
16
Show member pathways
7.9IL13, IL3, IL5, IL4, CCL11, RNASE3
17
Show member pathways
7.8CCL22, CCL11, IL4, IL5, IL3, IL13
18
Show member pathways
7.8CCL22, CCL11, IL4, IL5, IL3, IL13
19
Show member pathways
7.8CCL22, CCL11, IL4, IL5, IL3, IL13
20
Show member pathways
7.8CCL22, CCL11, IL4, IL5, IL3, IL13
21
Show member pathways
7.8CCL22, CCL11, IL4, IL5, IL3, IL13

Compounds for genes affiliated with Keratoconjunctivitis

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45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 61Tocris Bioscience, 51PharmGKB
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Compounds related to Keratoconjunctivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1unicap459.7RNASE3, CCL11, IL5
2omalizumab45 1110.6IL4, IL5, IL13
3sodium cromoglycate459.5RNASE3, CCL11, IL5
4lte4459.5RNASE3, CCL11, IL5
5ovomucoid459.5IL4, IL5, IL13
6pranlukast45 29 1111.4IL5, IL4, CCL11, RNASE3
7formoterol45 29 1111.3IL13, IL4, RNASE3
8cetirizine45 29 24 1112.3IL5, CCL11, RNASE3
9rolipram45 61 2911.3CCL11, IL4, IL5, IL13
10salbutamol45 51 29 24 1113.3RNASE3, CCL11, IL5, IL13
11praziquantel45 1110.3RNASE3, IL4, IL5, IL13
12pgd2459.3RNASE3, CCL11, IL5, IL13
13nedocromil sodium459.1RNASE3, IL4, IL5, IL3
14azelastine45 1110.1IL3, IL5, IL4, RNASE3
15poly(i-c)459.1CCL11, IL4, IL5, IL3
16gm-csf45 2910.0IL13, IL3, IL5, IL4
17n-formylmethionyl-leucylphenylalanine459.0IL3, IL5, CCL11, RNASE3
18ltd4459.0RNASE3, IL5, IL3, IL13
19mip 1alpha459.0IL13, IL3, IL4
20salmeterol45 51 29 1112.0RNASE3, CCL11, IL4, IL5, IL13
21montelukast45 51 29 1112.0RNASE3, CCL11, IL4, IL5, IL13
22budesonide45 51 1111.0RNASE3, CCL11, IL4, IL5, IL13
23fluticasone propionate45 51 61 1112.0RNASE3, CCL11, IL4, IL5, IL13
24il 10458.9IL4, IL5, IL3, IL13
25theophylline45 29 24 1111.9IL13, IL5, RNASE3, NGF
26tarc458.9CCL22, CCL11, IL4, IL5, IL13
27prednisolone45 29 1110.8NGF, RNASE3, CCL11, IL5, IL13
28ltc4458.8RNASE3, CCL11, IL5, IL3, IL13
29ionomycin458.7CCL11, IL4, IL5, IL3, IL13
30indomethacin45 29 61 1111.7IL13, IL5, IL4, CCL11, NGF
31herbimycin a45 619.7NGF, CCL11, IL4, IL5, IL3
32fmlp458.7RNASE3, CCL11, IL5, IL3, IL13
33capsaicin45 299.6NGF, RNASE3, CMA1, IL5
34methacholine45 51 1110.5RNASE3, CCL22, CCL11, IL4, IL5, IL13
35pge2458.4RNASE3, CCL22, CCL11, IL4, IL5, IL13
36sb 20358045 619.3NGF, CCL22, CCL11, IL4, IL5, IL13
37aspirin45 51 29 2411.3NGF, RNASE3, CCL22, CCL11, IL4, IL13
38tacrolimus45 51 1110.3CCL22, CCL11, IL4, IL5, IL3, IL13
39leukotriene b445 61 2410.2RNASE3, CCL22, CCL11, IL5, IL3, IL13
40ly294002458.2NGF, CCL11, IL4, IL5, IL3, IL13
41allergens458.2RNASE3, CMA1, CCL11, IL4, IL5, IL13
42thymidine45 249.2NGF, CCL11, IL4, IL5, IL3, IL13
43vegf458.0NGF, RNASE3, CCL11, IL4, IL5, IL13
44actinomycin d457.9NGF, CCL11, IL4, IL3, IL13
45rantes457.9RNASE3, CCL22, CCL11, IL4, IL5, IL3
46heparin45 29 24 1110.8RNASE3, CMA1, CCL11, IL5, IL3, IL13
47adenylate457.6NGF, RNASE3, CCL22, IL4, IL5, IL3
48cyclosporin a45 29 619.4NGF, RNASE3, CCL22, CCL11, IL4, IL5
49dexamethasone45 51 29 1110.3NGF, RNASE3, CCL22, CCL11, IL4, IL5
50histamine45 29 248.5IL13, NGF, RNASE3, CMA1, CCL22, CCL11

GO Terms for genes affiliated with Keratoconjunctivitis

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16Gene Ontology
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Cellular components related to Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.3CCL22, CCL11, IL4, IL5, IL3, IL13
2extracellular regionGO:0055766.2IL13, NGF, RNASE3, CMA1, CCL22, CCL11

Biological processes related to Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1regulation of proton transportGO:0101559.8IL13, IL4
2response to radiationGO:0093149.6NGF, CCL11
3positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.6IL3, IL4
4response to nicotineGO:0350949.6NGF, IL13
5positive regulation of B cell proliferationGO:0308909.5IL13, IL5, IL4
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.5IL3, IL5
7positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4NGF, IL4, IL5
8chemotaxisGO:0069359.4IL4, CCL11, CCL22
9extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.3IL4, NGF
10cell-cell signalingGO:0072678.8IL13, IL3, CCL22
11inflammatory responseGO:0069548.5NGF, CCL22, CCL11, IL5, IL13
12immune responseGO:0069558.1IL13, IL3, IL5, IL4, CCL11, CCL22

Molecular functions related to Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.6CCL11, CCL22
2growth factor activityGO:0080838.5IL3, IL5, IL4, NGF
3cytokine activityGO:0051258.4IL4, IL5, IL3, IL13

Products for genes affiliated with Keratoconjunctivitis

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  • Antibodies
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Sources for Keratoconjunctivitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet