KCS
MCID: KRT001
MIFTS: 60

Keratoconjunctivitis Sicca (KCS) malady

Rare diseases, Eye diseases categories

Summaries for Keratoconjunctivitis Sicca

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66Wikipedia, 34MalaCards
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Wikipedia:66 Keratoconjunctivitis sicca (KCS), also called dry eye syndrome (DES) or keratitis sicca, is an eye... more...

MalaCards: Keratoconjunctivitis Sicca, also known as keratitis sicca, is related to sjogren's syndrome and arthritis. An important gene associated with Keratoconjunctivitis Sicca is LTF (lactotransferrin), and among its related pathways are Cytokines and Inflammatory Response and Hematopoietic cell lineage. The drugs sodium chloride and hydroxyethyl cellulose and the compounds oxazolone and pilocarpine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and liver, and related mouse phenotypes are liver/biliary system and digestive/alimentary.

Aliases & Classifications for Keratoconjunctivitis Sicca

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44NIH Rare Diseases, 63UMLS, 9Disease Ontology, 11DISEASES, 46Novoseek, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases


Aliases & Descriptions:

keratoconjunctivitis sicca 9 44 11 46
keratitis sicca 44 63
xerophthalmia 44 63
keraconjunctivitis sicca 9
dry eye syndromes 63
dry eye syndrome 44
kcs 9


External Ids:

Disease Ontology9 DOID:12895
MeSH36 D007638

Related Diseases for Keratoconjunctivitis Sicca

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Keratoconjunctivitis Sicca:



Diseases related to keratoconjunctivitis sicca

Symptoms for Keratoconjunctivitis Sicca

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Drugs & Therapeutics for Keratoconjunctivitis Sicca

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Keratoconjunctivitis Sicca

Search CenterWatch for Keratoconjunctivitis Sicca

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Keratoconjunctivitis Sicca

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Anatomical Context for Keratoconjunctivitis Sicca

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34MalaCards
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MalaCards organs/tissues related to Keratoconjunctivitis Sicca:

34
Eye, Testes, Liver, T cells, Salivary gland, Bone, Bone marrow

Animal Models for Keratoconjunctivitis Sicca or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Keratoconjunctivitis Sicca:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8LTF, IL4, HSPG2, CFTR
2MP:00053818.4CFTR, HSPG2, IL4, NRTN
3MP:00030128.1CFTR, NGF, IL4, CD79A
4MP:00053918.0CFTR, NGF, HSPG2, IL4, NRTN
5MP:00053977.8CFTR, HSPG2, IL4, IL1A, CD79A, LTF
6MP:00036317.8CD79A, NRTN, IL4, HSPG2, NGF
7MP:00053877.4LTF, CFTR, HSPG2, IL4, IL1A, NRTN
8MP:00053767.0CFTR, NGF, HSPG2, IL4, IL1A, CD79A

Publications for Keratoconjunctivitis Sicca

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Sources:
53PubMed
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Articles related to Keratoconjunctivitis Sicca:

(show top 50)    (show all 309)
idTitleAuthorsYear
1
Corneal sequestrum in a dog with chronic unilateral keratoconjunctivitis sicca. (24299547)
2013
2
Use of linseed oil to treat experimentally induced keratoconjunctivitis sicca in rabbits. (23514268)
2013
3
The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca. (19668545)
2009
4
SjAPgren keratoconjunctivitis sicca treated with rituximab. (17667631)
2007
5
Topical 0.1% prednisolone lowers nerve growth factor expression in keratoconjunctivitis sicca patients. (16360211)
2006
6
Effect of cyclosporin A eye drop on keratoconjunctivitis sicca and its mechanism. (16696343)
2005
7
Histologic characteristics and local cellular immunity of the gland of the third eyelid after topical ophthalmic administration of 2% cyclosporine for treatment of dogs with keratoconjunctivitis sicca. (12013470)
2002
8
A double-blind, randomized, placebo-controlled study of cevimeline in SjAPgren's syndrome patients with xerostomia and keratoconjunctivitis sicca. (11920411)
2002
9
Estrogen therapy in keratoconjunctivitis sicca. (9635003)
1998
10
The association of conjunctival snake-like chromatin with keratoconjunctivitis SICCA. (9891892)
1998
11
Transplantation of the autologous submandibular gland for most severe cases of keratoconjunctivitis sicca. (9479295)
1998
12
Use of pilocarpine for treatment of keratoconjunctivitis sicca. (7619143)
1995
13
Microorganisms isolated from the corneal surface before and during topical cyclosporine treatment in dogs with keratoconjunctivitis sicca. (7574155)
1995
14
Treatment of keratoconjunctivitis sicca: the use of a simple self-administered eye irrigation system. (8000754)
1994
15
Sclerosing peritonitis associated with keratoconjunctivitis sicca, pleurisy, and secretory otitis media. (8358122)
1993
16
Impression cytology in patients with keratoconjunctivitis sicca. (8110974)
1993
17
Pilot trial of cyclosporine 1% ophthalmic ointment in the treatment of keratoconjunctivitis sicca. (8339560)
1993
18
Keratoconjunctivitis sicca and diabetes mellitus in a dog. (1639704)
1992
19
Unpreserved carboxymethylcellulose artificial tears evaluated in patients with keratoconjunctivitis sicca. (1424648)
1992
20
Figurate erythema, photosensitivity, and conjunctival irritation of recent onset. Subacute cutaneous lupus erythematosus (SCLE) and keratoconjunctivitis sicca. (1519943)
1992
21
Ocular manifestations of SjAPgren's syndrome: keratoconjunctivitis sicca. (1496163)
1992
22
Acute dacryocystitis after punctal occlusion of keratoconjunctivitis sicca. (2039051)
1991
23
A new perspective on canine keratoconjunctivitis sicca. Treatment with ophthalmic cyclosporine. (2194349)
1990
24
Sulfonamides and keratoconjunctivitis sicca. (2303377)
1990
25
Keratoconjunctivitis sicca associated with fracture of the stylohyoid bone in a horse. (2917892)
1989
26
Keratoconjunctivitis sicca in rheumatoid arthritis. (3262029)
1988
27
Keratoconjunctivitis sicca in the dog following 5-aminosalicylic acid administration. (3679245)
1987
28
Keratoconjunctivitis sicca and the treatment of canine colitis. (2878518)
1986
29
Treatment of keratoconjunctivitis sicca with Lacrisert. (3296154)
1986
30
Beneficial effect of topical fibronectin in patients with keratoconjunctivitis sicca of SjAPgren's syndrome. (4045849)
1985
31
Possible drug-induced keratoconjunctivitis sicca in a dog. (4060547)
1985
32
Keratoconjunctivitis sicca in the dog associated with the administration of salicylazosulphapyridine (sulphasalazine). (2860750)
1985
33
Keratoconjunctivitis sicca: immunological evaluation of 62 canine cases. (3888007)
1985
34
Scleroderma, keratoconjunctivitis sicca, and soft contact lens treatment. (6481067)
1984
35
Tear osmolarity and ocular surface disease in keratoconjunctivitis sicca. (475632)
1979
36
Osmolarity of tear microvolumes in keratoconjunctivitis sicca. (646697)
1978
37
Keratoconjunctivitis sicca following excision of a dermolipoma of the lacrimal gland. (736416)
1978
38
Keratoconjunctivitis sicca. (960384)
1976
39
Keratoconjunctivitis sicca in the dog produced by oral phenazopyridine hydrochloride. (4803915)
1973
40
Primary biliary cirrhosis, scleroderma and keratoconjunctivitis sicca. (4777031)
1973
41
Keratoconjunctivitis sicca induced by phenazopyridine in dogs. (4746647)
1973
42
A statistical aid to the diagnosis of keratoconjunctivitis sicca. (4561432)
1972
43
Hydrophilic lens therapy of severe keratoconjunctivitis sicca and conjunctival scarring. (5091116)
1971
44
Lacrimal insufficiency, keratoconjunctivitis sicca and malfunction of the inferior turbinate in the wide nose or open nasal space syndrome (Cottle). (13897379)
1962
45
Pulmonary infection in SjAPgren's disease (keratoconjunctivitis sicca): a report of a fatal case. (13264875)
1955
46
Congenital alacrimia and keratoconjunctivitis sicca in children. (13217790)
1954
47
The lacrimal fluid in keratoconjunctivitis sicca; a quantitative and qualitative investigation. (14923771)
1952
48
Studies on keratoconjunctivitis sicca, based on examination of 500 subjects affected with rheumatism and an equally large control material. (18878068)
1948
49
Notes on Keratoconjunctivitis Sicca. (16693337)
1943
50
Keratoconjunctivitis Sicca. (16693211)
1940

Variations for Keratoconjunctivitis Sicca

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Expression for genes affiliated with Keratoconjunctivitis Sicca

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratoconjunctivitis Sicca

Search GEO for disease gene expression data for Keratoconjunctivitis Sicca.

Pathways for genes affiliated with Keratoconjunctivitis Sicca

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN, 61Thomson Reuters
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Pathways related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3IL4, IL1A
29.3IL1A, IL4
39.3IL1A, IL4
4
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.9IL1A, IL4, CFTR
5
Show member pathways
8.8CD79A, IL1A, IL4
6
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.8CD79A, IL1A, IL4

Compounds for genes affiliated with Keratoconjunctivitis Sicca

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
1oxazolone469.6IL1A, IL4
2pilocarpine46 30 1211.6CFTR, HSPG2, CD79A
3fluoride469.5CFTR, HSPG2, CD79A
4n-formylmethionyl-leucylphenylalanine469.4HSPG2, LTF, IL1A
5methacholine46 52 1211.4CD79A, LTF, IL4
6polymyxin b469.3IL1A, IL4, LTF
7pentoxifylline46 1210.2LTF, IL4, IL1A
8atropine46 30 1211.1HSPG2, LTF, NGF
9c2ceramide469.1NGF, HSPG2, LTF
10hypoxanthine46 25 1211.1LTF, NGF, IL4
11suramin46 30 1211.1IL4, CFTR, CD79A, HSPG2
12ivig469.0CD79A, IL1A, IL4
13propranolol46 30 52 25 1213.0LTF, HSPG2, NGF
14n acetylcysteine469.0IL4, CD79A, LTF, CFTR
15capsaicin46 3010.0CFTR, LTF, HSPG2, NGF
16isoproterenol46 129.9IL1A, LTF, IL4, CFTR
17neopterin468.9CD79A, IL1A, IL4, LTF
18phenylephrine46 30 25 1211.8NGF, HSPG2, IL1A
19neomycin468.8NGF, HSPG2, IL1A
20thapsigargin46 629.7IL4, NGF, CFTR, HSPG2
21prostacyclin468.7LTF, NGF, IL1A, HSPG2
22azathioprine46 3 52 1211.7NGF, CD79A, LTF, IL4
23ascorbic acid46 259.6LTF, CD79A, HSPG2, CFTR, IL1A
24biotin46 25 1210.6CD79A, IL4, NGF, CFTR
25h2o2468.5CD79A, CFTR, HSPG2, IL1A, LTF
26heparin46 30 25 1211.5CD79A, LTF, HSPG2, IL1A, NRTN
27herbimycin a46 629.5IL1A, HSPG2, NGF, IL4
28epinephrine46 25 1210.4NGF, CFTR, CD79A, IL1A
29pdtc468.4IL1A, IL4, NGF
30vitamin d468.4IL1A, CD79A, NGF, CFTR
31paraffin468.4CFTR, LTF, IL4, CD79A
32adenylate468.4IL4, CFTR, NGF, HSPG2, LTF
33histamine46 30 2510.3NGF, HSPG2, IL4, CD79A, LTF
34alanine468.3LTF, NGF, HSPG2, CD79A, CFTR
35glutamine468.3HSPG2, CFTR, IL1A, LTF, NGF
36aspirin46 52 30 2511.3CFTR, CD79A, IL4, HSPG2, NGF
37forskolin46 52 1210.2HSPG2, NGF, CFTR, IL1A
38phosphatidylcholine468.2HSPG2, IL1A, CD79A, LTF, NGF
39norepinephrine46 25 1210.2NGF, CD79A, CFTR, LTF, IL1A
40carbachol46 30 1210.2IL1A, NGF, CFTR, CD79A, HSPG2
41actinomycin d468.2LTF, IL1A, IL4, CFTR, NGF
42pge2468.1CFTR, LTF, HSPG2, IL4, IL1A, CD79A
43cysteine467.9CD79A, IL4, NGF, CFTR, LTF
44acetylcholine46 52 30 25 1211.7NRTN, IL1A, HSPG2, NGF, CD79A, CFTR
45vegf467.7IL4, HSPG2, NGF, CD79A, IL1A, LTF
46cyclosporin a46 30 629.7CD79A, CFTR, NGF, LTF, IL4, IL1A
47glutamate467.4CD79A, NRTN, NGF, CFTR, LTF, IL1A
48retinoic acid46 258.4IL1A, LTF, NRTN, CD79A, HSPG2, CFTR
49indomethacin46 30 62 1210.3HSPG2, IL1A, CD79A, NGF, CFTR, LTF
50dexamethasone46 52 30 1210.3HSPG2, IL1A, NGF, CFTR, LTF, CD79A

GO Terms for genes affiliated with Keratoconjunctivitis Sicca

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17Gene Ontology
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Cellular components related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.3HSPG2, NGF
2extracellular spaceGO:0056157.7LTF, IL1A, IL4, HSPG2, NGF
3extracellular regionGO:0055767.6NGF, HSPG2, IL1A, NRTN, LTF

Biological processes related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1innate immune response in mucosaGO:0022279.8LTF, IL4
2response to cytokineGO:0340979.5IL4, CFTR
3response to peptide hormoneGO:0434349.3CFTR, NGF
4B cell differentiationGO:0301839.1IL4, CD79A
5transmembrane receptor protein tyrosine kinase signaling pathwayGO:0071699.1NRTN, NGF
6response to drugGO:0424938.8IL4, NGF, CFTR
7negative regulation of apoptotic processGO:0430668.8LTF, IL4, NGF
8extrinsic apoptotic signaling pathway in absence of ligandGO:0971928.7IL1A, IL4, NGF

Molecular functions related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080838.7NRTN, IL4, NGF

Products for genes affiliated with Keratoconjunctivitis Sicca

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Sources for Keratoconjunctivitis Sicca

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet