KCS
MCID: KRT001
MIFTS: 60

Keratoconjunctivitis Sicca (KCS) malady

Rare diseases, Eye diseases categories
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Summaries for Keratoconjunctivitis Sicca

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65Wikipedia, 33MalaCards
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Wikipedia:65 Keratoconjunctivitis sicca (KCS), also called dry eye syndrome (DES) or keratitis sicca, is an eye... more...

MalaCards: Keratoconjunctivitis Sicca, also known as keratitis sicca, is related to sjogren's syndrome and arthritis. An important gene associated with Keratoconjunctivitis Sicca is LTF (lactotransferrin), and among its related pathways are Cytokines and Inflammatory Response and Hematopoietic cell lineage. The drugs sodium chloride and hydroxyethyl cellulose and the compounds oxazolone and pilocarpine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and liver, and related mouse phenotypes are liver/biliary system and digestive/alimentary.

Aliases & Classifications for Keratoconjunctivitis Sicca

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43NIH Rare Diseases, 62UMLS, 8Disease Ontology, 10DISEASES, 45Novoseek, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases


Aliases & Descriptions:

keratoconjunctivitis sicca 8 43 10 45
keratitis sicca 43 62
xerophthalmia 43 62
keraconjunctivitis sicca 8
dry eye syndromes 62
dry eye syndrome 43
kcs 8


External Ids:

Disease Ontology8 DOID:12895
MeSH35 D007638

Related Diseases for Keratoconjunctivitis Sicca

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Keratoconjunctivitis Sicca:



Diseases related to keratoconjunctivitis sicca

Symptoms for Keratoconjunctivitis Sicca

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Drugs & Therapeutics for Keratoconjunctivitis Sicca

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Keratoconjunctivitis Sicca

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Anatomical Context for Keratoconjunctivitis Sicca

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33MalaCards
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MalaCards organs/tissues related to Keratoconjunctivitis Sicca:

33
Eye, Testes, Liver, T cells, Salivary gland, Bone, Bone marrow

Animal Models for Keratoconjunctivitis Sicca or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Keratoconjunctivitis Sicca:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8LTF, IL4, HSPG2, CFTR
2MP:00053818.4CFTR, HSPG2, IL4, NRTN
3MP:00030128.1CFTR, NGF, IL4, CD79A
4MP:00053918.0CFTR, NGF, HSPG2, IL4, NRTN
5MP:00053977.8CFTR, HSPG2, IL4, IL1A, CD79A, LTF
6MP:00036317.8CD79A, NRTN, IL4, HSPG2, NGF
7MP:00053877.4LTF, CFTR, HSPG2, IL4, IL1A, NRTN
8MP:00053767.0CFTR, NGF, HSPG2, IL4, IL1A, CD79A

Publications for Keratoconjunctivitis Sicca

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52PubMed
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Articles related to Keratoconjunctivitis Sicca:

(show top 50)    (show all 309)
idTitleAuthorsYear
1
Corneal sequestrum in a dog with chronic unilateral keratoconjunctivitis sicca. (24299547)
2013
2
Use of linseed oil to treat experimentally induced keratoconjunctivitis sicca in rabbits. (23514268)
2013
3
The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca. (19668545)
2009
4
SjAPgren keratoconjunctivitis sicca treated with rituximab. (17667631)
2007
5
Topical 0.1% prednisolone lowers nerve growth factor expression in keratoconjunctivitis sicca patients. (16360211)
2006
6
Effect of cyclosporin A eye drop on keratoconjunctivitis sicca and its mechanism. (16696343)
2005
7
Histologic characteristics and local cellular immunity of the gland of the third eyelid after topical ophthalmic administration of 2% cyclosporine for treatment of dogs with keratoconjunctivitis sicca. (12013470)
2002
8
A double-blind, randomized, placebo-controlled study of cevimeline in SjAPgren's syndrome patients with xerostomia and keratoconjunctivitis sicca. (11920411)
2002
9
Estrogen therapy in keratoconjunctivitis sicca. (9635003)
1998
10
The association of conjunctival snake-like chromatin with keratoconjunctivitis SICCA. (9891892)
1998
11
Transplantation of the autologous submandibular gland for most severe cases of keratoconjunctivitis sicca. (9479295)
1998
12
Use of pilocarpine for treatment of keratoconjunctivitis sicca. (7619143)
1995
13
Microorganisms isolated from the corneal surface before and during topical cyclosporine treatment in dogs with keratoconjunctivitis sicca. (7574155)
1995
14
Treatment of keratoconjunctivitis sicca: the use of a simple self-administered eye irrigation system. (8000754)
1994
15
Sclerosing peritonitis associated with keratoconjunctivitis sicca, pleurisy, and secretory otitis media. (8358122)
1993
16
Impression cytology in patients with keratoconjunctivitis sicca. (8110974)
1993
17
Pilot trial of cyclosporine 1% ophthalmic ointment in the treatment of keratoconjunctivitis sicca. (8339560)
1993
18
Keratoconjunctivitis sicca and diabetes mellitus in a dog. (1639704)
1992
19
Unpreserved carboxymethylcellulose artificial tears evaluated in patients with keratoconjunctivitis sicca. (1424648)
1992
20
Figurate erythema, photosensitivity, and conjunctival irritation of recent onset. Subacute cutaneous lupus erythematosus (SCLE) and keratoconjunctivitis sicca. (1519943)
1992
21
Ocular manifestations of SjAPgren's syndrome: keratoconjunctivitis sicca. (1496163)
1992
22
Acute dacryocystitis after punctal occlusion of keratoconjunctivitis sicca. (2039051)
1991
23
A new perspective on canine keratoconjunctivitis sicca. Treatment with ophthalmic cyclosporine. (2194349)
1990
24
Sulfonamides and keratoconjunctivitis sicca. (2303377)
1990
25
Keratoconjunctivitis sicca associated with fracture of the stylohyoid bone in a horse. (2917892)
1989
26
Keratoconjunctivitis sicca in rheumatoid arthritis. (3262029)
1988
27
Keratoconjunctivitis sicca in the dog following 5-aminosalicylic acid administration. (3679245)
1987
28
Keratoconjunctivitis sicca and the treatment of canine colitis. (2878518)
1986
29
Treatment of keratoconjunctivitis sicca with Lacrisert. (3296154)
1986
30
Beneficial effect of topical fibronectin in patients with keratoconjunctivitis sicca of SjAPgren's syndrome. (4045849)
1985
31
Possible drug-induced keratoconjunctivitis sicca in a dog. (4060547)
1985
32
Keratoconjunctivitis sicca in the dog associated with the administration of salicylazosulphapyridine (sulphasalazine). (2860750)
1985
33
Keratoconjunctivitis sicca: immunological evaluation of 62 canine cases. (3888007)
1985
34
Scleroderma, keratoconjunctivitis sicca, and soft contact lens treatment. (6481067)
1984
35
Tear osmolarity and ocular surface disease in keratoconjunctivitis sicca. (475632)
1979
36
Osmolarity of tear microvolumes in keratoconjunctivitis sicca. (646697)
1978
37
Keratoconjunctivitis sicca following excision of a dermolipoma of the lacrimal gland. (736416)
1978
38
Keratoconjunctivitis sicca. (960384)
1976
39
Keratoconjunctivitis sicca in the dog produced by oral phenazopyridine hydrochloride. (4803915)
1973
40
Primary biliary cirrhosis, scleroderma and keratoconjunctivitis sicca. (4777031)
1973
41
Keratoconjunctivitis sicca induced by phenazopyridine in dogs. (4746647)
1973
42
A statistical aid to the diagnosis of keratoconjunctivitis sicca. (4561432)
1972
43
Hydrophilic lens therapy of severe keratoconjunctivitis sicca and conjunctival scarring. (5091116)
1971
44
Lacrimal insufficiency, keratoconjunctivitis sicca and malfunction of the inferior turbinate in the wide nose or open nasal space syndrome (Cottle). (13897379)
1962
45
Pulmonary infection in SjAPgren's disease (keratoconjunctivitis sicca): a report of a fatal case. (13264875)
1955
46
Congenital alacrimia and keratoconjunctivitis sicca in children. (13217790)
1954
47
The lacrimal fluid in keratoconjunctivitis sicca; a quantitative and qualitative investigation. (14923771)
1952
48
Studies on keratoconjunctivitis sicca, based on examination of 500 subjects affected with rheumatism and an equally large control material. (18878068)
1948
49
Notes on Keratoconjunctivitis Sicca. (16693337)
1943
50
Keratoconjunctivitis Sicca. (16693211)
1940

Variations for Keratoconjunctivitis Sicca

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Expression for genes affiliated with Keratoconjunctivitis Sicca

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratoconjunctivitis Sicca

Search GEO for disease gene expression data for Keratoconjunctivitis Sicca.

Pathways for genes affiliated with Keratoconjunctivitis Sicca

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 60Thomson Reuters
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Pathways related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3IL4, IL1A
29.3IL1A, IL4
39.3IL1A, IL4
4
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.9IL1A, IL4, CFTR
5
Show member pathways
8.8CD79A, IL1A, IL4
6
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
8.8CD79A, IL1A, IL4

Compounds for genes affiliated with Keratoconjunctivitis Sicca

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
1oxazolone459.6IL1A, IL4
2pilocarpine45 29 1111.6CFTR, HSPG2, CD79A
3fluoride459.5CFTR, HSPG2, CD79A
4n-formylmethionyl-leucylphenylalanine459.4HSPG2, LTF, IL1A
5methacholine45 51 1111.4CD79A, LTF, IL4
6polymyxin b459.3IL1A, IL4, LTF
7pentoxifylline45 1110.2LTF, IL4, IL1A
8atropine45 29 1111.1HSPG2, LTF, NGF
9c2ceramide459.1NGF, HSPG2, LTF
10hypoxanthine45 24 1111.1LTF, NGF, IL4
11suramin45 29 1111.1IL4, CFTR, CD79A, HSPG2
12ivig459.0CD79A, IL1A, IL4
13propranolol45 29 51 24 1113.0LTF, HSPG2, NGF
14n acetylcysteine459.0IL4, CD79A, LTF, CFTR
15capsaicin45 2910.0CFTR, LTF, HSPG2, NGF
16isoproterenol45 119.9IL1A, LTF, IL4, CFTR
17neopterin458.9CD79A, IL1A, IL4, LTF
18phenylephrine45 29 24 1111.8NGF, HSPG2, IL1A
19neomycin458.8NGF, HSPG2, IL1A
20thapsigargin45 619.7IL4, NGF, CFTR, HSPG2
21prostacyclin458.7LTF, NGF, IL1A, HSPG2
22azathioprine45 3 51 1111.7NGF, CD79A, LTF, IL4
23ascorbic acid45 249.6LTF, CD79A, HSPG2, CFTR, IL1A
24biotin45 24 1110.6CD79A, IL4, NGF, CFTR
25h2o2458.5CD79A, CFTR, HSPG2, IL1A, LTF
26heparin45 29 24 1111.5CD79A, LTF, HSPG2, IL1A, NRTN
27herbimycin a45 619.5IL1A, HSPG2, NGF, IL4
28epinephrine45 24 1110.4NGF, CFTR, CD79A, IL1A
29pdtc458.4IL1A, IL4, NGF
30vitamin d458.4IL1A, CD79A, NGF, CFTR
31paraffin458.4CFTR, LTF, IL4, CD79A
32adenylate458.4IL4, CFTR, NGF, HSPG2, LTF
33histamine45 29 2410.3NGF, HSPG2, IL4, CD79A, LTF
34alanine458.3LTF, NGF, HSPG2, CD79A, CFTR
35glutamine458.3HSPG2, CFTR, IL1A, LTF, NGF
36aspirin45 51 29 2411.3CFTR, CD79A, IL4, HSPG2, NGF
37forskolin45 51 1110.2HSPG2, NGF, CFTR, IL1A
38phosphatidylcholine458.2HSPG2, IL1A, CD79A, LTF, NGF
39norepinephrine45 24 1110.2NGF, CD79A, CFTR, LTF, IL1A
40carbachol45 29 1110.2IL1A, NGF, CFTR, CD79A, HSPG2
41actinomycin d458.2LTF, IL1A, IL4, CFTR, NGF
42pge2458.1CFTR, LTF, HSPG2, IL4, IL1A, CD79A
43cysteine457.9CD79A, IL4, NGF, CFTR, LTF
44acetylcholine45 51 29 24 1111.7NRTN, IL1A, HSPG2, NGF, CD79A, CFTR
45vegf457.7IL4, HSPG2, NGF, CD79A, IL1A, LTF
46cyclosporin a45 29 619.7CD79A, CFTR, NGF, LTF, IL4, IL1A
47glutamate457.4CD79A, NRTN, NGF, CFTR, LTF, IL1A
48retinoic acid45 248.4IL1A, LTF, NRTN, CD79A, HSPG2, CFTR
49indomethacin45 29 61 1110.3HSPG2, IL1A, CD79A, NGF, CFTR, LTF
50dexamethasone45 51 29 1110.3HSPG2, IL1A, NGF, CFTR, LTF, CD79A

GO Terms for genes affiliated with Keratoconjunctivitis Sicca

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16Gene Ontology
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Cellular components related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.3HSPG2, NGF
2extracellular spaceGO:0056157.7LTF, IL1A, IL4, HSPG2, NGF
3extracellular regionGO:0055767.6NGF, HSPG2, IL1A, NRTN, LTF

Biological processes related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1innate immune response in mucosaGO:0022279.8LTF, IL4
2response to cytokineGO:0340979.5IL4, CFTR
3response to peptide hormoneGO:0434349.3CFTR, NGF
4B cell differentiationGO:0301839.1IL4, CD79A
5transmembrane receptor protein tyrosine kinase signaling pathwayGO:0071699.1NRTN, NGF
6response to drugGO:0424938.8IL4, NGF, CFTR
7negative regulation of apoptotic processGO:0430668.8LTF, IL4, NGF
8extrinsic apoptotic signaling pathway in absence of ligandGO:0971928.7IL1A, IL4, NGF

Molecular functions related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080838.7NRTN, IL4, NGF

Products for genes affiliated with Keratoconjunctivitis Sicca

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  • Antibodies
  • Proteins
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Sources for Keratoconjunctivitis Sicca

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet