KCS
MCID: KRT001
MIFTS: 60

Keratoconjunctivitis Sicca (KCS) malady

Rare diseases, Eye diseases categories
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Summaries for Keratoconjunctivitis Sicca

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Wikipedia:65 Keratoconjunctivitis sicca (KCS), also called dry eye syndrome (DES) or keratitis sicca, is an eye... more...

MalaCards based summary: Keratoconjunctivitis Sicca, also known as dry eye syndrome, is related to dry eye syndrome and sjogren's syndrome. An important gene associated with Keratoconjunctivitis Sicca is LTF (lactotransferrin), and among its related pathways are Hematopoietic cell lineage and Cytokine Network. The drugs sodium chloride and sodium chloride granules and the compounds oxazolone and pilocarpine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and liver, and related mouse phenotypes are liver/biliary system and digestive/alimentary.

Aliases & Classifications for Keratoconjunctivitis Sicca

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Keratoconjunctivitis Sicca, Aliases & Descriptions:

Name: Keratoconjunctivitis Sicca 8 42 10 44 62
Dry Eye Syndrome 42 62
Keratitis Sicca 42 62
 
Xerophthalmia 42 62
Keraconjunctivitis Sicca 8
Kcs 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:12895
MeSH34 D007638

Related Diseases for Keratoconjunctivitis Sicca

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Diseases related to Keratoconjunctivitis Sicca via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1dry eye syndrome31.3HSPG2
2sjogren's syndrome31.1HSPG2, CD79A, LTF
3conjunctivitis30.9CD79A
4arthritis30.8IL4, IL1A, LTF
5otitis media30.7LTF, CD79A
6pneumonia30.6HSPG2, CD79A, CFTR
7uveitis30.6IL4, IL1A
8corneal disease30.6IL1A, NGF
9primary biliary cirrhosis30.5LTF, CD79A, HSPG2
10cystic fibrosis30.5LTF, CFTR, HSPG2
11colitis30.4LTF, NGF, IL4
12diarrhea30.3CD79A, CFTR, LTF
13rheumatoid arthritis30.1CFTR, HSPG2, IL1A, CD79A, LTF, IL4
14dermatitis29.9IL1A, CD79A, IL4
15keratoconjunctivitis11.4
16xerophthalmia11.2
17lactose intolerance10.5LTF
18exocrine pancreatic insufficiency10.5CFTR
19cholangitis10.5CFTR
20cryptosporidiosis10.5CD79A
21aspergillosis10.5CD79A
22urethritis10.4CD79A
23corneal ulcer10.4
24blindness10.4
25periapical granuloma10.4IL4
26keratomalacia10.4
27allergic conjunctivitis10.3
28graft versus host disease10.3
29keratoconus10.3
30achalasia10.3
31rosacea10.3
32dacryoadenitis10.3
33ectropion10.3
34esophagitis10.3
35keratitis10.3
36sarcoidosis10.3
37scleroderma10.3
38adrenocortical insufficiency10.3
39night blindness10.3
40primary sclerosing cholangitis10.3CFTR, LTF
41bronchitis10.3CFTR, LTF
42polyneuropathy10.3HSPG2, CD79A
43prostatitis10.3CD79A, LTF
44sinusitis10.3CFTR, CD79A
45connective tissue disease10.3HSPG2, LTF
46shigellosis10.3LTF, CD79A
47reactive arthritis10.3LTF, CD79A
48allergic bronchopulmonary aspergillosis10.3CFTR, IL4
49purpura10.3HSPG2, CD79A
50dental caries10.3CD79A, LTF

Graphical network of the top 20 diseases related to Keratoconjunctivitis Sicca:



Diseases related to keratoconjunctivitis sicca

Symptoms for Keratoconjunctivitis Sicca

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Drugs & Therapeutics for Keratoconjunctivitis Sicca

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Genetic Tests for Keratoconjunctivitis Sicca

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Anatomical Context for Keratoconjunctivitis Sicca

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MalaCards organs/tissues related to Keratoconjunctivitis Sicca:

32
Eye, Testes, Liver, T cells, Salivary gland, Bone, Bone marrow

Animal Models for Keratoconjunctivitis Sicca or affiliated genes

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MGI Mouse Phenotypes related to Keratoconjunctivitis Sicca:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8LTF, CFTR, IL4, HSPG2
2MP:00053818.4NRTN, IL4, HSPG2, CFTR
3MP:00030128.1CFTR, CD79A, IL4, NGF
4MP:00053918.0NRTN, IL4, HSPG2, NGF, CFTR
5MP:00053977.8LTF, CD79A, IL1A, HSPG2, CFTR, IL4
6MP:00036317.8NGF, HSPG2, NRTN, CD79A, IL4
7MP:00053877.4CFTR, IL4, IL1A, NRTN, HSPG2, CD79A
8MP:00053767.0LTF, CFTR, HSPG2, NGF, IL4, CD79A

Publications for Keratoconjunctivitis Sicca

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Articles related to Keratoconjunctivitis Sicca:

(show top 50)    (show all 316)
idTitleAuthorsYear
1
The Role of Chlamydia Pneumoniae in the Etiology Keratoconjunctivitis Sicca (KCS). (25395268)
2014
2
Effect of rebamipide ophthalmic suspension on signs and symptoms of keratoconjunctivitis sicca in SjAPgren syndrome patients with or without punctal occlusions. (24977983)
2014
3
Corneal sequestrum in a dog with chronic unilateral keratoconjunctivitis sicca. (24299547)
2013
4
Use of linseed oil to treat experimentally induced keratoconjunctivitis sicca in rabbits. (23514268)
2013
5
The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca. (19668545)
2009
6
Topical 0.1% prednisolone lowers nerve growth factor expression in keratoconjunctivitis sicca patients. (16360211)
2006
7
Effect of cyclosporin A eye drop on keratoconjunctivitis sicca and its mechanism. (16696343)
2005
8
Histologic characteristics and local cellular immunity of the gland of the third eyelid after topical ophthalmic administration of 2% cyclosporine for treatment of dogs with keratoconjunctivitis sicca. (12013470)
2002
9
A double-blind, randomized, placebo-controlled study of cevimeline in SjAPgren's syndrome patients with xerostomia and keratoconjunctivitis sicca. (11920411)
2002
10
Estrogen therapy in keratoconjunctivitis sicca. (9635003)
1998
11
The association of conjunctival snake-like chromatin with keratoconjunctivitis SICCA. (9891892)
1998
12
Transplantation of the autologous submandibular gland for most severe cases of keratoconjunctivitis sicca. (9479295)
1998
13
Use of pilocarpine for treatment of keratoconjunctivitis sicca. (7619143)
1995
14
Microorganisms isolated from the corneal surface before and during topical cyclosporine treatment in dogs with keratoconjunctivitis sicca. (7574155)
1995
15
Treatment of keratoconjunctivitis sicca: the use of a simple self-administered eye irrigation system. (8000754)
1994
16
Sclerosing peritonitis associated with keratoconjunctivitis sicca, pleurisy, and secretory otitis media. (8358122)
1993
17
Impression cytology in patients with keratoconjunctivitis sicca. (8110974)
1993
18
Pilot trial of cyclosporine 1% ophthalmic ointment in the treatment of keratoconjunctivitis sicca. (8339560)
1993
19
Keratoconjunctivitis sicca and diabetes mellitus in a dog. (1639704)
1992
20
Unpreserved carboxymethylcellulose artificial tears evaluated in patients with keratoconjunctivitis sicca. (1424648)
1992
21
Keratoconjunctivitis sicca in a patient with a Jones tube to treat sleep apnea. (1642310)
1992
22
Ocular manifestations of SjAPgren's syndrome: keratoconjunctivitis sicca. (1496163)
1992
23
Acute dacryocystitis after punctal occlusion of keratoconjunctivitis sicca. (2039051)
1991
24
A new perspective on canine keratoconjunctivitis sicca. Treatment with ophthalmic cyclosporine. (2194349)
1990
25
Sulfonamides and keratoconjunctivitis sicca. (2303377)
1990
26
Keratoconjunctivitis sicca associated with fracture of the stylohyoid bone in a horse. (2917892)
1989
27
Keratoconjunctivitis sicca in rheumatoid arthritis. (3262029)
1988
28
Keratoconjunctivitis sicca in the dog following 5-aminosalicylic acid administration. (3679245)
1987
29
Keratoconjunctivitis sicca and the treatment of canine colitis. (2878518)
1986
30
Treatment of keratoconjunctivitis sicca with Lacrisert. (3296154)
1986
31
Beneficial effect of topical fibronectin in patients with keratoconjunctivitis sicca of SjAPgren's syndrome. (4045849)
1985
32
Possible drug-induced keratoconjunctivitis sicca in a dog. (4060547)
1985
33
Keratoconjunctivitis sicca in the dog associated with the administration of salicylazosulphapyridine (sulphasalazine). (2860750)
1985
34
Keratoconjunctivitis sicca: immunological evaluation of 62 canine cases. (3888007)
1985
35
Scleroderma, keratoconjunctivitis sicca, and soft contact lens treatment. (6481067)
1984
36
Tear osmolarity and ocular surface disease in keratoconjunctivitis sicca. (475632)
1979
37
Osmolarity of tear microvolumes in keratoconjunctivitis sicca. (646697)
1978
38
Keratoconjunctivitis sicca following excision of a dermolipoma of the lacrimal gland. (736416)
1978
39
Keratoconjunctivitis sicca. (960384)
1976
40
Keratoconjunctivitis sicca in the dog produced by oral phenazopyridine hydrochloride. (4803915)
1973
41
Primary biliary cirrhosis, scleroderma and keratoconjunctivitis sicca. (4777031)
1973
42
A statistical aid to the diagnosis of keratoconjunctivitis sicca. (4561432)
1972
43
Hydrophilic lens therapy of severe keratoconjunctivitis sicca and conjunctival scarring. (5091116)
1971
44
Lacrimal insufficiency, keratoconjunctivitis sicca and malfunction of the inferior turbinate in the wide nose or open nasal space syndrome (Cottle). (13897379)
1962
45
Pulmonary infection in SjAPgren's disease (keratoconjunctivitis sicca): a report of a fatal case. (13264875)
1955
46
Congenital alacrimia and keratoconjunctivitis sicca in children. (13217790)
1954
47
The lacrimal fluid in keratoconjunctivitis sicca; a quantitative and qualitative investigation. (14923771)
1952
48
Studies on keratoconjunctivitis sicca, based on examination of 500 subjects affected with rheumatism and an equally large control material. (18878068)
1948
49
Notes on Keratoconjunctivitis Sicca. (16693337)
1943
50
Keratoconjunctivitis Sicca. (16693211)
1940

Variations for Keratoconjunctivitis Sicca

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Expression for genes affiliated with Keratoconjunctivitis Sicca

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Expression patterns in normal tissues for genes affiliated with Keratoconjunctivitis Sicca

Search GEO for disease gene expression data for Keratoconjunctivitis Sicca.

Pathways for genes affiliated with Keratoconjunctivitis Sicca

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Pathways related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3IL1A, IL4
29.3IL1A, IL4
39.3IL1A, IL4
4
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.9IL1A, IL4, CFTR
5
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.8IL4, CD79A, IL1A
6
Show member pathways
8.8CD79A, IL1A, IL4

Compounds for genes affiliated with Keratoconjunctivitis Sicca

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Compounds related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
1oxazolone449.6IL1A, IL4
2pilocarpine44 28 1111.6CFTR, HSPG2, CD79A
3fluoride449.5CFTR, HSPG2, CD79A
4n-formylmethionyl-leucylphenylalanine449.4HSPG2, LTF, IL1A
5methacholine44 50 1111.4CD79A, LTF, IL4
6polymyxin b449.3IL1A, IL4, LTF
7pentoxifylline44 1110.2LTF, IL4, IL1A
8atropine44 28 1111.1HSPG2, LTF, NGF
9c2ceramide449.1NGF, HSPG2, LTF
10hypoxanthine44 24 1111.1LTF, NGF, IL4
11suramin44 28 1111.1IL4, CFTR, CD79A, HSPG2
12ivig449.0CD79A, IL1A, IL4
13propranolol44 28 50 24 1113.0LTF, HSPG2, NGF
14n acetylcysteine449.0IL4, CD79A, LTF, CFTR
15capsaicin44 2810.0CFTR, LTF, HSPG2, NGF
16isoproterenol44 119.9IL1A, LTF, IL4, CFTR
17neopterin448.9CD79A, IL1A, IL4, LTF
18phenylephrine44 28 24 1111.8NGF, HSPG2, IL1A
19neomycin448.8NGF, HSPG2, IL1A
20thapsigargin44 619.7IL4, NGF, CFTR, HSPG2
21prostacyclin448.7LTF, NGF, IL1A, HSPG2
22azathioprine44 2 50 1111.7NGF, CD79A, LTF, IL4
23ascorbic acid44 249.6LTF, CD79A, HSPG2, CFTR, IL1A
24biotin44 24 1110.6CD79A, IL4, NGF, CFTR
25h2o2448.5CD79A, CFTR, HSPG2, IL1A, LTF
26heparin44 28 24 1111.5CD79A, LTF, HSPG2, IL1A, NRTN
27herbimycin a44 619.5IL1A, HSPG2, NGF, IL4
28epinephrine44 24 1110.4NGF, CFTR, CD79A, IL1A
29pdtc448.4IL1A, IL4, NGF
30vitamin d448.4IL1A, CD79A, NGF, CFTR
31paraffin448.4CFTR, LTF, IL4, CD79A
32adenylate448.4IL4, CFTR, NGF, HSPG2, LTF
33histamine44 28 2410.3NGF, HSPG2, IL4, CD79A, LTF
34alanine448.3LTF, NGF, HSPG2, CD79A, CFTR
35glutamine448.3HSPG2, CFTR, IL1A, LTF, NGF
36aspirin44 50 28 2411.3CFTR, CD79A, IL4, HSPG2, NGF
37forskolin44 50 1110.2HSPG2, NGF, CFTR, IL1A
38phosphatidylcholine448.2HSPG2, IL1A, CD79A, LTF, NGF
39norepinephrine44 24 1110.2NGF, CD79A, CFTR, LTF, IL1A
40carbachol44 28 1110.2IL1A, NGF, CFTR, CD79A, HSPG2
41actinomycin d448.2LTF, IL1A, IL4, CFTR, NGF
42pge2448.1CFTR, LTF, HSPG2, IL4, IL1A, CD79A
43cysteine447.9CD79A, IL4, NGF, CFTR, LTF
44acetylcholine44 50 28 24 1111.7NRTN, IL1A, HSPG2, NGF, CD79A, CFTR
45vegf447.7IL4, HSPG2, NGF, CD79A, IL1A, LTF
46cyclosporin a44 28 619.7CD79A, CFTR, NGF, LTF, IL4, IL1A
47glutamate447.4CD79A, NRTN, NGF, CFTR, LTF, IL1A
48retinoic acid44 248.4IL1A, LTF, NRTN, CD79A, HSPG2, CFTR
49indomethacin44 28 61 1110.3HSPG2, IL1A, CD79A, NGF, CFTR, LTF
50dexamethasone44 50 28 1110.3HSPG2, IL1A, NGF, CFTR, LTF, CD79A

GO Terms for genes affiliated with Keratoconjunctivitis Sicca

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Cellular components related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.3HSPG2, NGF
2extracellular spaceGO:0056157.7IL1A, NGF, HSPG2, IL4, LTF
3extracellular regionGO:0055767.6LTF, NGF, HSPG2, IL1A, NRTN

Biological processes related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1innate immune response in mucosaGO:0022279.8LTF, IL4
2response to cytokineGO:0340979.5IL4, CFTR
3response to peptide hormoneGO:0434349.3CFTR, NGF
4B cell differentiationGO:0301839.1IL4, CD79A
5transmembrane receptor protein tyrosine kinase signaling pathwayGO:0071699.1NRTN, NGF
6response to drugGO:0424938.8IL4, NGF, CFTR
7negative regulation of apoptotic processGO:0430668.8LTF, IL4, NGF
8extrinsic apoptotic signaling pathway in absence of ligandGO:0971928.7IL1A, IL4, NGF

Molecular functions related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080838.7NRTN, IL4, NGF

Products for genes affiliated with Keratoconjunctivitis Sicca

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  • Antibodies
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Sources for Keratoconjunctivitis Sicca

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet