KCS
MCID: KRT001
MIFTS: 54

Keratoconjunctivitis Sicca (KCS) malady

Summaries for Keratoconjunctivitis Sicca

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63Wikipedia, 32MalaCards
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Wikipedia:63 Keratoconjunctivitis sicca (KCS), also called keratitis sicca,xerophthalmia or dry eye syndrome (DES) is... more...

MalaCards: Keratoconjunctivitis Sicca, also known as keratitis sicca, is related to sjogren's syndrome and arthritis. An important gene associated with Keratoconjunctivitis Sicca is LTF (lactotransferrin), and among its related pathways are Gastric acid secretion and Cytokines and Inflammatory Response. The drugs sodium chloride and hydroxyethyl cellulose and the compounds glutamate and suramin have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and liver, and related mouse phenotypes are digestive/alimentary and vision/eye.

Aliases & Classifications for Keratoconjunctivitis Sicca

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

keratoconjunctivitis sicca 8 42 10 44
keratitis sicca 42 60
xerophthalmia 42 60
keraconjunctivitis sicca 8
dry eye syndromes 60
dry eye syndrome 42
kcs 8


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Disease Ontology8 DOID:12895
MeSH34 D007638

Related Diseases for Keratoconjunctivitis Sicca

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17GeneCards, 18GeneDecks
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Diseases related to Keratoconjunctivitis Sicca via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1sjogren's syndrome30.8HSPG2, TRIM21, LTF, CD79A, AQP5
2arthritis30.7LTF, IL4, IL1A, LYZ
3rheumatoid arthritis30.7HSPG2, TRIM21, LTF, CD79A, IL4, IL1A
4dry eye syndrome30.5HSPG2, LTF, AQP5
5dacryoadenitis30.4HSPG2
6erythema multiforme30.4HSPG2
7sarcoidosis30.4LYZ, IL1A
8corneal disease30.4NGF, IL1A
9uveitis30.4IL1A, IL4
10conjunctivitis30.2CD79A
11otitis media30.2CD79A, LTF
12lupus erythematosus30.2CD79A, TRIM21
13diabetes mellitus30.2CD79A, NGF
14eye disease30.2NGF, LYZ
15primary biliary cirrhosis30.2HSPG2, LTF, CD79A
16pneumonia30.2HSPG2, CD79A, CFTR
17cystic fibrosis30.2AQP5, CFTR, LTF, HSPG2
18blepharitis30.0LTF
19thyroiditis30.0CD79A
20crohn's disease30.0LTF, LYZ
21diarrhea30.0LTF, CD79A, CFTR
22ovarian cancer29.9IL1A
23dermatitis29.9CD79A, IL4, IL1A
24hypertension29.8CD79A
25keratoconjunctivitis11.4
26xerophthalmia11.1
27corneal ulcer10.4
28keratomalacia10.3
29allergic conjunctivitis10.3
30graft versus host disease10.3
31rosacea10.3
32achalasia10.3
33ectropion10.3
34esophagitis10.3
35keratoconus10.3
36scleroderma10.3
37night blindness10.2
38measles10.1
39bone fracture10.1
40cutaneous lupus erythematosus10.1
41ocular albinism10.1
42acute dacryocystitis10.1
43juvenile rheumatoid arthritis10.1
44cataract10.1
45chromosomal disease10.1
46collagen disease10.1
47dacryocystitis10.1
48diabetic retinopathy10.1
49hypothyroidism10.1
50keratitis10.1

Graphical network of the top 20 diseases related to Keratoconjunctivitis Sicca:



Diseases related to keratoconjunctivitis sicca

Clinical Features for Keratoconjunctivitis Sicca

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Drugs & Therapeutics for Keratoconjunctivitis Sicca

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Keratoconjunctivitis Sicca

Drug clinical trials:

Search ClinicalTrials for Keratoconjunctivitis Sicca

Search NIH Clinical Center for Keratoconjunctivitis Sicca

Search CenterWatch for Keratoconjunctivitis Sicca

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Keratoconjunctivitis Sicca

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Anatomical Context for Keratoconjunctivitis Sicca

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32MalaCards
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MalaCards organs/tissues related to Keratoconjunctivitis Sicca:

32
Eye, Testes, Liver, T cells, Salivary gland, Bone, Bone marrow

Animal Models for Keratoconjunctivitis Sicca or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Keratoconjunctivitis Sicca:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.3AQP5, CFTR, IL4, NRTN, HSPG2
2MP:00053917.8HSPG2, NRTN, NGF, IL4, CFTR, AQP5
3MP:00030127.6NGF, CD79A, IL4, CFTR, AQP5
4MP:00053977.0HSPG2, TRIM21, LTF, CD79A, IL4, IL1A
5MP:00053876.9HSPG2, NRTN, TRIM21, LTF, CD79A, IL4
6MP:00053766.4AQP5, HSPG2, TRIM21, LTF, NGF, CD79A

Publications for Keratoconjunctivitis Sicca

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50PubMed
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Articles related to Keratoconjunctivitis Sicca:

(show top 50)    (show all 314)
idTitleAuthorsYear
1
Corneal sequestrum in a dog with chronic unilateral keratoconjunctivitis sicca. (24299547)
2013
2
A topical aqueous calcineurin inhibitor for the treatment of naturally occurring keratoconjunctivitis sicca in dogs. (22853450)
2013
3
Long-term Supplementation With n-6 and n-3 PUFAs Improves Moderate-to-Severe Keratoconjunctivitis Sicca: A Randomized Double-Blind Clinical Trial. (23884332)
2013
4
Canine neurogenic Keratoconjunctivitis sicca: 11 cases (2006-2010). (22051024)
2012
5
An experimental study of the management of severe keratoconjunctivitis sicca with autologous reduced-sized submandibular gland transplantation. (22051179)
2012
6
Proteomic analysis of secretion from human transplanted submandibular gland replacing lacrimal gland with severe keratoconjunctivitis sicca. (22306964)
2012
7
Keratoconjunctivitis sicca manifestations in ocular graft versus host disease: pathogenesis, presentation, prevention, and treatment. (21958171)
2011
8
Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. (20007286)
2010
9
Study of autoantibodies in patients with keratoconjunctivitis sicca infected by the human T cell lymphotropic virus type 1. (19639323)
2010
10
Chlamydia pneumoniae in the etiology of the keratoconjunctivitis sicca in adult patients (a pilot study)]. (19642357)
2009
11
Clinical evaluation of pimecrolimus eye drops for treatment of canine keratoconjunctivitis sicca: a comparison with cyclosporine A. (17950639)
2009
12
New test to quantify lipid layer behavior in healthy subjects and patients with keratoconjunctivitis sicca. (18724144)
2008
13
Long-term results of autologous submandibular gland transfer for the surgical treatment of severe keratoconjunctivitis sicca. (18406158)
2008
14
Alginate inserts loaded with epidermal growth factor for the treatment of keratoconjunctivitis sicca. (18484491)
2008
15
Immunopathogenesis of keratoconjunctivitis sicca in the dog. (18299006)
2008
16
Keratoconjunctivitis sicca associated with administration of etodolac in dogs: 211 cases (1992-2002). (17302553)
2007
17
Canine keratoconjunctivitis sicca: disease trends in a review of 229 cases. (17381766)
2007
18
The effect of topical pimecrolimus on keratoconjunctivitis sicca and chronic superficial keratitis in dogs: results from an exploratory study. (15644099)
2005
19
Microvascular autologous submandibular gland transfer in severe cases of keratoconjunctivitis sicca. (15287305)
2004
20
Histologic characteristics and local cellular immunity of the gland of the third eyelid after topical ophthalmic administration of 2% cyclosporine for treatment of dogs with keratoconjunctivitis sicca. (12013470)
2002
21
Immunopathogenesis of conjunctival histopathologic alteration in non-SjAPgren's keratoconjunctivitis sicca. (12613995)
2002
22
Group IIA phospholipase A2 content of tears in patients with keratoconjunctivitis sicca. (12136279)
2002
23
Epstein-Barr virus dacryoadenitis resulting in keratoconjunctivitis sicca in a child. (11730660)
2001
24
Microvascular submandibular gland transfer for severe cases of keratoconjunctivitis sicca. (10987460)
2000
25
Microvascular submandibular gland transfer for severe cases of keratoconjunctivitis sicca. Sieg P,*(1) geerling G, kosmehl H, lauer I, warnecke K, von domarus H. Plast reconstr surg 2000;106:554-560 (11124324)
2000
26
Investigating a viral etiology for keratoconjunctivitis sicca among patients who are positive for human immunodeficiency virus. (10571297)
1999
27
The association of conjunctival snake-like chromatin with keratoconjunctivitis SICCA. (9891892)
1998
28
Keratoconjunctivitis sicca in SjAPgren's syndrome: diagnostic significance of relative protein composition of tears]. (9621821)
1998
29
Keratoconjunctivitis sicca, autoimmune diseases and adenovirus type 8 infection. (22827333)
1996
30
Microorganisms isolated from the corneal surface before and during topical cyclosporine treatment in dogs with keratoconjunctivitis sicca. (7574155)
1995
31
Cellular immunity in dogs with keratoconjunctivitis sicca before and after treatment with topical 2% cyclosporine. (8746695)
1995
32
Treatment of keratoconjunctivitis sicca in dogs with cyclosporine ophthalmic ointment: a European clinical field trial. (8588275)
1995
33
Diagnosis of keratoconjunctivitis sicca. (8169072)
1994
34
Impression cytology in patients with keratoconjunctivitis sicca. (8110974)
1993
35
Keratoconjunctivitis sicca in a patient with a Jones tube to treat sleep apnea. (1642310)
1992
36
Topical fibronectin in the treatment of keratoconjunctivitis sicca. Chiron Keratoconjunctivitis Sicca Study Group. (1415455)
1992
37
Sulfonamides and keratoconjunctivitis sicca. (2303377)
1990
38
Diagnosis and differential diagnosis of keratoconjunctivitis sicca associated with tear gland degeneration. (2245523)
1990
39
Sodium hyaluronate in the treatment of keratoconjunctivitis sicca. A double masked clinical trial. (2658462)
1989
40
The ocular surface in keratoconjunctivitis sicca. (2606217)
1989
41
Tear function parameters in keratoconjunctivitis sicca with and without the association of SjAPgren's syndrome. (3173983)
1988
42
Tear diluents in the treatment of keratoconjunctivitis sicca. (4011138)
1985
43
Scleroderma, keratoconjunctivitis sicca, and soft contact lens treatment. (6481067)
1984
44
Keratoconjunctivitis sicca: histopathologic study of nictitating membrane and lacrimal glands from 28 dogs. (6703444)
1984
45
Diagnostic tests in keratoconjunctivitis sicca. (6839430)
1983
46
Keratoconjunctivitis sicca. (960384)
1976
47
Keratoconjunctivitis sicca symptoms appearing after blepharoplasty. The "dry eye" syndrome. (1244611)
1976
48
Is the lacrimal gland dispensable? Keratoconjunctivitis sicca after lacrimal gland removal. (1119971)
1975
49
Histology of the lacrimal gland in keratoconjunctivitis sicca. (4785251)
1973
50
Filter-paper electrophoresis of tears. I. Lysozyme and its correlation with keratoconjunctivitis sicca. (13228566)
1955

Genetic Variations for Keratoconjunctivitis Sicca

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Expression for genes affiliated with Keratoconjunctivitis Sicca

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratoconjunctivitis Sicca

Search GEO for disease gene expression data for Keratoconjunctivitis Sicca.

Pathways for genes affiliated with Keratoconjunctivitis Sicca

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29KEGG, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7LYZ, AQP5
29.0IL1A, IL4
39.0IL1A, IL4
4
Hide members
8.5IL1A, IL4, CD79A

Compounds for genes affiliated with Keratoconjunctivitis Sicca

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1glutamate4410.6NRTN
2suramin44 28 1112.6CFTR
3norepinephrine44 11 2412.3CFTR, LTF
4thapsigargin44 5911.2HSPG2, CFTR
5carbachol44 28 1111.8HSPG2, CD79A, CFTR
6cellulose triacetate449.8LTF, IL1A
7hypothiocyanite44 2410.7CD79A, LTF
8fluoride449.7HSPG2, CD79A, CFTR
9atropine44 28 1111.6HSPG2, NGF, LTF
10c2ceramide449.6HSPG2, LTF, NGF
11n-formylmethionyl-leucylphenylalanine449.6IL1A, LTF, HSPG2
12capsaicin44 2810.5CFTR, NGF, LTF, HSPG2
13propranolol44 28 49 11 2413.4NGF, LTF, HSPG2
14acetylcholine44 49 28 11 2413.4CFTR, NGF, NRTN, HSPG2
15pilocarpine44 28 1111.4CD79A, CFTR, AQP5, HSPG2
16oxazolone449.4IL1A, IL4
17h2o2449.4CD79A, CFTR, HSPG2, LTF
18phenylephrine44 28 11 2412.2HSPG2, NGF, IL1A
19neomycin449.2NGF, HSPG2, IL1A
20hypoxanthine44 11 2411.2NGF, IL4, LTF
21methacholine44 1110.2LTF, IL4, CD79A
22polymyxin b449.1LTF, IL1A, IL4
23prostacyclin449.1NGF, IL1A, LTF, HSPG2
24glycerol44 11 2411.1CFTR, CD79A, AQP5, NGF
25pentoxifylline44 1110.0LTF, IL4, IL1A
26ascorbic acid44 249.8IL1A, HSPG2, CFTR, CD79A, LTF
27glutamine448.8NGF, HSPG2, LTF, CFTR, IL1A
28isoproterenol44 119.8LTF, IL4, CFTR, IL1A
29ivig448.8IL1A, CD79A, IL4
30n acetylcysteine448.8CD79A, IL4, LTF, CFTR
31epinephrine44 11 2410.8CD79A, IL1A, CFTR, NGF
32heparin44 28 11 2411.8NRTN, HSPG2, LTF, CD79A, IL1A
33azathioprine44 49 2 1111.7IL4, CD79A, LTF, NGF
34chloroquine44 2 49 28 1112.7CD79A, IL4, CFTR
35biotin44 11 2410.7CD79A, CFTR, NGF, IL4
36phosphatidylcholine448.7IL1A, CD79A, NGF, HSPG2, LTF
37neopterin448.6IL4, LTF, CD79A, IL1A
38vitamin d448.6CFTR, NGF, CD79A, IL1A
39herbimycin a44 599.6IL1A, IL4, NGF, HSPG2
40adenylate448.6NGF, LTF, HSPG2, CFTR, IL4
41pdtc448.5NGF, IL4, IL1A
42histamine44 28 2410.4HSPG2, LTF, NGF, CD79A, IL4
43aspirin44 49 28 2411.4IL4, CFTR, NGF, HSPG2, CD79A
44actinomycin d448.3CFTR, IL1A, IL4, NGF, LTF
45polyethylene glycol448.2CD79A, IL1A, IL4
46retinoic acid44 249.0CD79A, IL1A, NGF, LTF, NRTN, HSPG2
47cyclosporin a44 28 599.8CFTR, NGF, LTF, CD79A, IL1A, IL4
48vegf447.8IL1A, HSPG2, LTF, NGF, CD79A, IL4
49indomethacin44 59 28 1110.5CFTR, CD79A, IL4, IL1A, LTF, HSPG2
50dexamethasone44 49 28 1110.5IL1A, HSPG2, LTF, IL4, CD79A, CFTR

GO Terms for genes affiliated with Keratoconjunctivitis Sicca

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16Gene Ontology
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Cellular components related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.8LYZ, IL1A, IL4, NGF, HSPG2
2extracellular regionGO:0055767.7LYZ, HSPG2, NRTN, LTF, NGF, IL1A

Molecular functions related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080838.8IL4, NGF, NRTN

Products for genes affiliated with Keratoconjunctivitis Sicca

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  • Antibodies
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Sources for Keratoconjunctivitis Sicca

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet