MCID: KRT001
MIFTS: 52

Keratoconjunctivitis Sicca malady

Rare diseases category

Aliases & Classifications for Keratoconjunctivitis Sicca

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Keratoconjunctivitis Sicca, Aliases & Descriptions:

Name: Keratoconjunctivitis Sicca 9 41 11 43 60
Keratitis Sicca 41 60
Xerophthalmia 41 60
Keraconjunctivitis Sicca 9
 
Dry Eye Syndromes 60
Dry Eye Syndrome 41
Kcs 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:12895
MeSH33 D007638

Summaries for Keratoconjunctivitis Sicca

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Wikipedia:63 Keratoconjunctivitis sicca (KCS), also called dry eye syndrome (DES) or keratitis sicca, is an eye... more...

MalaCards based summary: Keratoconjunctivitis Sicca, also known as keratitis sicca, is related to dry eye syndrome and sjogren's syndrome. An important gene associated with Keratoconjunctivitis Sicca is LTF (lactotransferrin), and among its related pathways are Cytokines and Inflammatory Response and Hematopoietic cell lineage. The drugs cod liver oil and vitamin a and the compounds oxazolone and pilocarpine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and liver, and related mouse phenotypes are liver/biliary system and digestive/alimentary.

Related Diseases for Keratoconjunctivitis Sicca

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Diseases related to Keratoconjunctivitis Sicca via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1dry eye syndrome31.2HSPG2
2sjogren's syndrome31.1HSPG2, CD79A, LTF
3conjunctivitis30.9CD79A
4arthritis30.8IL4, IL1A, LTF
5otitis media30.6LTF, CD79A
6pneumonia30.6HSPG2, CD79A, CFTR
7corneal disease30.5IL1A, NGF
8uveitis30.5IL4, IL1A
9primary biliary cirrhosis30.5LTF, CD79A, HSPG2
10cystic fibrosis30.5LTF, CFTR, HSPG2
11colitis30.4LTF, NGF, IL4
12diarrhea30.3CD79A, CFTR, LTF
13rheumatoid arthritis30.0CFTR, HSPG2, IL1A, CD79A, LTF, IL4
14dermatitis29.9IL1A, CD79A, IL4
15keratoconjunctivitis11.4
16xerophthalmia11.2
17lactose intolerance10.5LTF
18exocrine pancreatic insufficiency10.5CFTR
19cholangitis10.5CFTR
20cryptosporidiosis10.5CD79A
21aspergillosis10.4CD79A
22urethritis10.4CD79A
23corneal ulcer10.4
24blindness10.4
25periapical granuloma10.4IL4
26keratomalacia10.4
27allergic conjunctivitis10.3
28keratitis10.3
29keratoconus10.3
30rosacea10.3
31achalasia10.3
32dacryoadenitis10.3
33ectropion10.3
34esophagitis10.3
35scleroderma10.3
36night blindness10.3
37cholangitis, primary sclerosing10.3CFTR, LTF
38bronchitis10.3CFTR, LTF
39polyneuropathy10.3HSPG2, CD79A
40prostatitis10.3CD79A, LTF
41sinusitis10.3CFTR, CD79A
42shigellosis10.3LTF, CD79A
43connective tissue disease10.3HSPG2, LTF
44reactive arthritis10.3LTF, CD79A
45allergic bronchopulmonary aspergillosis10.3CFTR, IL4
46purpura10.3HSPG2, CD79A
47dental caries10.2CD79A, LTF
48hematopoietic stem cell transplantation10.2
49thyroiditis10.2
50membranous glomerulonephritis, antenatal10.2HSPG2, CD79A

Graphical network of the top 20 diseases related to Keratoconjunctivitis Sicca:



Diseases related to keratoconjunctivitis sicca

Symptoms for Keratoconjunctivitis Sicca

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Drugs & Therapeutics for Keratoconjunctivitis Sicca

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Genetic Tests for Keratoconjunctivitis Sicca

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Anatomical Context for Keratoconjunctivitis Sicca

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MalaCards organs/tissues related to Keratoconjunctivitis Sicca:

31
Eye, Testes, Liver, T cells, Salivary gland, Bone, Bone marrow

Animal Models for Keratoconjunctivitis Sicca or affiliated genes

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MGI Mouse Phenotypes related to Keratoconjunctivitis Sicca:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8LTF, CFTR, IL4, HSPG2
2MP:00053818.4NRTN, IL4, HSPG2, CFTR
3MP:00030128.1CFTR, CD79A, IL4, NGF
4MP:00053918.0NRTN, IL4, HSPG2, NGF, CFTR
5MP:00053977.8LTF, CD79A, IL1A, HSPG2, CFTR, IL4
6MP:00036317.8NGF, HSPG2, NRTN, CD79A, IL4
7MP:00053877.4CFTR, IL4, IL1A, NRTN, HSPG2, CD79A
8MP:00053767.0LTF, CFTR, HSPG2, NGF, IL4, CD79A

Publications for Keratoconjunctivitis Sicca

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Articles related to Keratoconjunctivitis Sicca:

(show top 50)    (show all 321)
idTitleAuthorsYear
1
Microvascular autologous submandibular gland transplantation in severe cases of keratoconjunctivitis sicca. (25664315)
2015
2
The Role of Chlamydia Pneumoniae in the Etiology Keratoconjunctivitis Sicca (KCS). (25395268)
2014
3
Effect of rebamipide ophthalmic suspension on signs and symptoms of keratoconjunctivitis sicca in SjAPgren syndrome patients with or without punctal occlusions. (24977983)
2014
4
Corneal sequestrum in a dog with chronic unilateral keratoconjunctivitis sicca. (24299547)
2013
5
Use of linseed oil to treat experimentally induced keratoconjunctivitis sicca in rabbits. (23514268)
2013
6
The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca. (19668545)
2009
7
Topical 0.1% prednisolone lowers nerve growth factor expression in keratoconjunctivitis sicca patients. (16360211)
2006
8
Effect of cyclosporin A eye drop on keratoconjunctivitis sicca and its mechanism. (16696343)
2005
9
Histologic characteristics and local cellular immunity of the gland of the third eyelid after topical ophthalmic administration of 2% cyclosporine for treatment of dogs with keratoconjunctivitis sicca. (12013470)
2002
10
A double-blind, randomized, placebo-controlled study of cevimeline in SjAPgren's syndrome patients with xerostomia and keratoconjunctivitis sicca. (11920411)
2002
11
Estrogen therapy in keratoconjunctivitis sicca. (9635003)
1998
12
The association of conjunctival snake-like chromatin with keratoconjunctivitis SICCA. (9891892)
1998
13
Transplantation of the autologous submandibular gland for most severe cases of keratoconjunctivitis sicca. (9479295)
1998
14
Use of pilocarpine for treatment of keratoconjunctivitis sicca. (7619143)
1995
15
Microorganisms isolated from the corneal surface before and during topical cyclosporine treatment in dogs with keratoconjunctivitis sicca. (7574155)
1995
16
Treatment of keratoconjunctivitis sicca: the use of a simple self-administered eye irrigation system. (8000754)
1994
17
Sclerosing peritonitis associated with keratoconjunctivitis sicca, pleurisy, and secretory otitis media. (8358122)
1993
18
Impression cytology in patients with keratoconjunctivitis sicca. (8110974)
1993
19
Pilot trial of cyclosporine 1% ophthalmic ointment in the treatment of keratoconjunctivitis sicca. (8339560)
1993
20
Keratoconjunctivitis sicca and diabetes mellitus in a dog. (1639704)
1992
21
Unpreserved carboxymethylcellulose artificial tears evaluated in patients with keratoconjunctivitis sicca. (1424648)
1992
22
Keratoconjunctivitis sicca in a patient with a Jones tube to treat sleep apnea. (1642310)
1992
23
Figurate erythema, photosensitivity, and conjunctival irritation of recent onset. Subacute cutaneous lupus erythematosus (SCLE) and keratoconjunctivitis sicca. (1519943)
1992
24
Ocular manifestations of SjAPgren's syndrome: keratoconjunctivitis sicca. (1496163)
1992
25
Acute dacryocystitis after punctal occlusion of keratoconjunctivitis sicca. (2039051)
1991
26
A new perspective on canine keratoconjunctivitis sicca. Treatment with ophthalmic cyclosporine. (2194349)
1990
27
Sulfonamides and keratoconjunctivitis sicca. (2303377)
1990
28
Keratoconjunctivitis sicca associated with fracture of the stylohyoid bone in a horse. (2917892)
1989
29
Keratoconjunctivitis sicca in rheumatoid arthritis. (3262029)
1988
30
Keratoconjunctivitis sicca and the treatment of canine colitis. (2878518)
1986
31
Treatment of keratoconjunctivitis sicca with Lacrisert. (3296154)
1986
32
Beneficial effect of topical fibronectin in patients with keratoconjunctivitis sicca of SjAPgren's syndrome. (4045849)
1985
33
Possible drug-induced keratoconjunctivitis sicca in a dog. (4060547)
1985
34
Keratoconjunctivitis sicca in the dog associated with the administration of salicylazosulphapyridine (sulphasalazine). (2860750)
1985
35
Keratoconjunctivitis sicca: immunological evaluation of 62 canine cases. (3888007)
1985
36
Scleroderma, keratoconjunctivitis sicca, and soft contact lens treatment. (6481067)
1984
37
Tear osmolarity and ocular surface disease in keratoconjunctivitis sicca. (475632)
1979
38
Osmolarity of tear microvolumes in keratoconjunctivitis sicca. (646697)
1978
39
Keratoconjunctivitis sicca following excision of a dermolipoma of the lacrimal gland. (736416)
1978
40
Keratoconjunctivitis sicca. (960384)
1976
41
Keratoconjunctivitis sicca in the dog produced by oral phenazopyridine hydrochloride. (4803915)
1973
42
Primary biliary cirrhosis, scleroderma and keratoconjunctivitis sicca. (4777031)
1973
43
A statistical aid to the diagnosis of keratoconjunctivitis sicca. (4561432)
1972
44
Hydrophilic lens therapy of severe keratoconjunctivitis sicca and conjunctival scarring. (5091116)
1971
45
Lacrimal insufficiency, keratoconjunctivitis sicca and malfunction of the inferior turbinate in the wide nose or open nasal space syndrome (Cottle). (13897379)
1962
46
Pulmonary infection in SjAPgren's disease (keratoconjunctivitis sicca): a report of a fatal case. (13264875)
1955
47
Congenital alacrimia and keratoconjunctivitis sicca in children. (13217790)
1954
48
The lacrimal fluid in keratoconjunctivitis sicca; a quantitative and qualitative investigation. (14923771)
1952
49
Studies on keratoconjunctivitis sicca, based on examination of 500 subjects affected with rheumatism and an equally large control material. (18878068)
1948
50
Notes on Keratoconjunctivitis Sicca. (16693337)
1943

Variations for Keratoconjunctivitis Sicca

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Expression for genes affiliated with Keratoconjunctivitis Sicca

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Search GEO for disease gene expression data for Keratoconjunctivitis Sicca.

Pathways for genes affiliated with Keratoconjunctivitis Sicca

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Pathways related to Keratoconjunctivitis Sicca according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3IL4, IL1A
29.3IL1A, IL4
39.3IL1A, IL4
4
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.9IL1A, IL4, CFTR
5
Show member pathways
8.8CD79A, IL1A, IL4
6
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.8CD79A, IL1A, IL4

Compounds for genes affiliated with Keratoconjunctivitis Sicca

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Compounds related to Keratoconjunctivitis Sicca according to GeneCards Suite gene sharing:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
1oxazolone439.6IL1A, IL4
2pilocarpine43 28 1211.6CFTR, HSPG2, CD79A
3fluoride439.5CFTR, HSPG2, CD79A
4n-formylmethionyl-leucylphenylalanine439.4HSPG2, LTF, IL1A
5methacholine43 49 1211.4CD79A, LTF, IL4
6polymyxin b439.3IL1A, IL4, LTF
7pentoxifylline43 1210.2LTF, IL4, IL1A
8atropine43 28 1211.1HSPG2, LTF, NGF
9c2ceramide439.1NGF, HSPG2, LTF
10hypoxanthine43 24 1211.1LTF, NGF, IL4
11suramin43 28 1211.1IL4, CFTR, CD79A, HSPG2
12ivig439.0CD79A, IL1A, IL4
13propranolol43 28 49 24 1213.0LTF, HSPG2, NGF
14n acetylcysteine439.0IL4, CD79A, LTF, CFTR
15capsaicin43 2810.0CFTR, LTF, HSPG2, NGF
16isoproterenol43 129.9IL1A, LTF, IL4, CFTR
17neopterin438.9CD79A, IL1A, IL4, LTF
18phenylephrine43 28 24 1211.8NGF, HSPG2, IL1A
19neomycin438.8NGF, HSPG2, IL1A
20thapsigargin43 599.7IL4, NGF, CFTR, HSPG2
21prostacyclin438.7LTF, NGF, IL1A, HSPG2
22azathioprine43 2 49 1211.7NGF, CD79A, LTF, IL4
23ascorbic acid43 249.6LTF, CD79A, HSPG2, CFTR, IL1A
24biotin43 24 1210.6CD79A, IL4, NGF, CFTR
25h2o2438.5CD79A, CFTR, HSPG2, IL1A, LTF
26heparin43 28 24 1211.5CD79A, LTF, HSPG2, IL1A, NRTN
27herbimycin a43 599.5IL1A, HSPG2, NGF, IL4
28epinephrine43 24 1210.4NGF, CFTR, CD79A, IL1A
29pdtc438.4IL1A, IL4, NGF
30vitamin d438.4IL1A, CD79A, NGF, CFTR
31paraffin438.4CFTR, LTF, IL4, CD79A
32adenylate438.4IL4, CFTR, NGF, HSPG2, LTF
33histamine43 28 2410.3NGF, HSPG2, IL4, CD79A, LTF
34alanine438.3LTF, NGF, HSPG2, CD79A, CFTR
35glutamine438.3HSPG2, CFTR, IL1A, LTF, NGF
36aspirin43 49 28 2411.3CFTR, CD79A, IL4, HSPG2, NGF
37forskolin43 49 1210.2HSPG2, NGF, CFTR, IL1A
38phosphatidylcholine438.2HSPG2, IL1A, CD79A, LTF, NGF
39norepinephrine43 24 1210.2NGF, CD79A, CFTR, LTF, IL1A
40carbachol43 28 1210.2IL1A, NGF, CFTR, CD79A, HSPG2
41actinomycin d438.2LTF, IL1A, IL4, CFTR, NGF
42pge2438.1CFTR, LTF, HSPG2, IL4, IL1A, CD79A
43cysteine437.9CD79A, IL4, NGF, CFTR, LTF
44acetylcholine43 49 28 24 1211.7NRTN, IL1A, HSPG2, NGF, CD79A, CFTR
45vegf437.7IL4, HSPG2, NGF, CD79A, IL1A, LTF
46cyclosporin a43 28 599.7CD79A, CFTR, NGF, LTF, IL4, IL1A
47glutamate437.4CD79A, NRTN, NGF, CFTR, LTF, IL1A
48retinoic acid43 248.4IL1A, LTF, NRTN, CD79A, HSPG2, CFTR
49indomethacin43 28 59 1210.3HSPG2, IL1A, CD79A, NGF, CFTR, LTF
50dexamethasone43 49 28 1210.3HSPG2, IL1A, NGF, CFTR, LTF, CD79A

GO Terms for genes affiliated with Keratoconjunctivitis Sicca

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Cellular components related to Keratoconjunctivitis Sicca according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00057969.3HSPG2, NGF
2extracellular spaceGO:00056157.7LTF, IL1A, IL4, HSPG2, NGF
3extracellular regionGO:00055767.6NGF, HSPG2, IL1A, NRTN, LTF

Biological processes related to Keratoconjunctivitis Sicca according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1innate immune response in mucosaGO:00022279.8LTF, IL4
2response to cytokineGO:00340979.5IL4, CFTR
3response to peptide hormoneGO:00434349.3CFTR, NGF
4B cell differentiationGO:00301839.1IL4, CD79A
5transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.1NRTN, NGF
6response to drugGO:00424938.8IL4, NGF, CFTR
7negative regulation of apoptotic processGO:00430668.8LTF, IL4, NGF
8extrinsic apoptotic signaling pathway in absence of ligandGO:00971928.7IL1A, IL4, NGF

Molecular functions related to Keratoconjunctivitis Sicca according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080838.7NRTN, IL4, NGF

Products for genes affiliated with Keratoconjunctivitis Sicca

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  • Antibodies
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Sources for Keratoconjunctivitis Sicca

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet