KCS
MCID: KRT001
MIFTS: 54

Keratoconjunctivitis Sicca (KCS) malady

Summaries for Keratoconjunctivitis Sicca

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63Wikipedia, 32MalaCards
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Wikipedia:63 Keratoconjunctivitis sicca (KCS), also called keratitis sicca,xerophthalmia or dry eye syndrome (DES) is... more...

MalaCards: Keratoconjunctivitis Sicca, also known as keratitis sicca, is related to sjogren's syndrome and arthritis. An important gene associated with Keratoconjunctivitis Sicca is LTF (lactotransferrin), and among its related pathways are Gastric acid secretion and Cytokines and Inflammatory Response. The drugs sodium chloride and hydroxyethyl cellulose and the compounds glutamate and suramin have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and liver, and related mouse phenotypes are digestive/alimentary and vision/eye.

Aliases & Classifications for Keratoconjunctivitis Sicca

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42NIH Rare Diseases, 60UMLS, 8Disease Ontology, 10DISEASES, 44Novoseek, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

keratoconjunctivitis sicca 8 42 10 44
keratitis sicca 42 60
xerophthalmia 42 60
keraconjunctivitis sicca 8
dry eye syndromes 60
dry eye syndrome 42
kcs 8


External Ids:

Disease Ontology8 DOID:12895
MeSH34 D007638

Related Diseases for Keratoconjunctivitis Sicca

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17GeneCards, 18GeneDecks
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Diseases related to Keratoconjunctivitis Sicca via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1sjogren's syndrome30.8HSPG2, TRIM21, LTF, CD79A, AQP5
2arthritis30.7LTF, IL4, IL1A, LYZ
3rheumatoid arthritis30.7HSPG2, TRIM21, LTF, CD79A, IL4, IL1A
4dry eye syndrome30.5HSPG2, LTF, AQP5
5dacryoadenitis30.4HSPG2
6erythema multiforme30.4HSPG2
7sarcoidosis30.4LYZ, IL1A
8corneal disease30.4NGF, IL1A
9uveitis30.4IL1A, IL4
10conjunctivitis30.2CD79A
11otitis media30.2CD79A, LTF
12lupus erythematosus30.2CD79A, TRIM21
13diabetes mellitus30.2CD79A, NGF
14eye disease30.2NGF, LYZ
15primary biliary cirrhosis30.2HSPG2, LTF, CD79A
16pneumonia30.2HSPG2, CD79A, CFTR
17cystic fibrosis30.2AQP5, CFTR, LTF, HSPG2
18blepharitis30.0LTF
19thyroiditis30.0CD79A
20crohn's disease30.0LTF, LYZ
21diarrhea30.0LTF, CD79A, CFTR
22ovarian cancer29.9IL1A
23dermatitis29.9CD79A, IL4, IL1A
24hypertension29.8CD79A
25keratoconjunctivitis11.4
26xerophthalmia11.1
27corneal ulcer10.4
28keratomalacia10.3
29allergic conjunctivitis10.3
30graft versus host disease10.3
31rosacea10.3
32achalasia10.3
33ectropion10.3
34esophagitis10.3
35keratoconus10.3
36scleroderma10.3
37night blindness10.2
38measles10.1
39bone fracture10.1
40cutaneous lupus erythematosus10.1
41ocular albinism10.1
42acute dacryocystitis10.1
43juvenile rheumatoid arthritis10.1
44cataract10.1
45chromosomal disease10.1
46collagen disease10.1
47dacryocystitis10.1
48diabetic retinopathy10.1
49hypothyroidism10.1
50keratitis10.1

Graphical network of the top 20 diseases related to Keratoconjunctivitis Sicca:



Diseases related to keratoconjunctivitis sicca

Clinical Features for Keratoconjunctivitis Sicca

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Drugs & Therapeutics for Keratoconjunctivitis Sicca

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Keratoconjunctivitis Sicca

Drug clinical trials:

Search ClinicalTrials for Keratoconjunctivitis Sicca

Search NIH Clinical Center for Keratoconjunctivitis Sicca

Search CenterWatch for Keratoconjunctivitis Sicca

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Keratoconjunctivitis Sicca

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Anatomical Context for Keratoconjunctivitis Sicca

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32MalaCards
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MalaCards organs/tissues related to Keratoconjunctivitis Sicca:

32
Eye, Testes, Liver, T cells, Salivary gland, Bone, Bone marrow

Animal Models for Keratoconjunctivitis Sicca or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Keratoconjunctivitis Sicca:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.3AQP5, CFTR, IL4, NRTN, HSPG2
2MP:00053917.8HSPG2, NRTN, NGF, IL4, CFTR, AQP5
3MP:00030127.6NGF, CD79A, IL4, CFTR, AQP5
4MP:00053977.0HSPG2, TRIM21, LTF, CD79A, IL4, IL1A
5MP:00053876.9HSPG2, NRTN, TRIM21, LTF, CD79A, IL4
6MP:00053766.4AQP5, HSPG2, TRIM21, LTF, NGF, CD79A

Publications for Keratoconjunctivitis Sicca

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50PubMed
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Articles related to Keratoconjunctivitis Sicca:

(show top 50)    (show all 314)
idTitleAuthorsYear
1
Autoimmunity in the pathogenesis and treatment of keratoconjunctivitis sicca. (24395332)
2014
2
Congenital keratoconjunctivitis sicca and ichthyosiform dermatosis in Cavalier King Charles spaniel dogs. Part II: candidate gene study. (22339941)
2012
3
Dacryocystorhinostomy precipitating keratoconjunctivitis sicca in aplasia of lacrimal and major salivary glands (ALSG). (21659912)
2012
4
Rose bengal staining of the temporal conjunctiva differentiates SjAPgren's syndrome from keratoconjunctivitis sicca. (20107179)
2010
5
The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca. (19668545)
2009
6
A new model of experimental autoimmune keratoconjunctivitis sicca (KCS) induced in Lewis rat by the autoantigen Klk1b22. (19060269)
2009
7
Recurrence after topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in SjAPgren's syndrome. (17341155)
2007
8
Comparison of topical dry eye medications for the treatment of keratoconjunctivitis sicca in a botulinum toxin B-induced mouse model. (17198019)
2007
9
Topical 0.1% prednisolone lowers nerve growth factor expression in keratoconjunctivitis sicca patients. (16360211)
2006
10
Dry eye (Keratoconjunctivitis Sicca), rheumatoid arthritis, and SjAPgren's syndrome. (16310468)
2005
11
Effect of topical 0.02% tacrolimus aqueous suspension on tear production in dogs with keratoconjunctivitis sicca. (16008701)
2005
12
Ocular surface changes in keratoconjunctivitis sicca with silicone punctum plug occlusion. (12854053)
2003
13
A double-blind, randomized, placebo-controlled study of cevimeline in SjAPgren's syndrome patients with xerostomia and keratoconjunctivitis sicca. (11920411)
2002
14
Transplantation of the autologous submandibular gland for most severe cases of keratoconjunctivitis sicca. (9479295)
1998
15
The role of apoptosis in the pathogenesis of canine keratoconjunctivitis sicca: the effect of topical Cyclosporin A therapy. (9820947)
1998
16
The effect of a new tear substitute containing glycerol and hyaluronate on keratoconjunctivitis sicca. (9867333)
1998
17
Keratoconjunctivitis sicca associated with achalasia of the cardia, adrenocortical insufficiency, and lacrimal gland degeneration: Keratoconjunctivitis sicca secondary to lacrimal gland degeneration may parallel degenerative changes in esophageal and adrenocortical function. (9544638)
1998
18
Keratoconjunctivitis sicca. Primary care response to a common eye problem. (9459953)
1997
19
Incidence of ocular complications in rheumatoid arthritis and the relation of keratoconjunctivitis sicca with its systemic activity. (9137326)
1997
20
Treatment of keratoconjunctivitis sicca in rabbits with 3-isobutyl-1-methylxanthine. (7527631)
1994
21
Bilateral keratoconjunctivitis sicca in a horse. (8575385)
1994
22
Rapid assay of lactoferrin in keratoconjunctivitis sicca. (7842709)
1994
23
Changes in the diagnostic parameters during keratoconjunctivitis sicca therapy. (1473446)
1992
24
A comparison of diagnostic tests for keratoconjunctivitis sicca: lactoplate, Schirmer, and tear osmolarity. (2112063)
1990
25
Conjunctival surface damage distribution in keratoconjunctivitis sicca. An impression cytology study. (2367078)
1990
26
Keratoconjunctivitis sicca with associated secondary uveitis elicited in rats after systemic xylazine/ketamine anesthesia. (2591501)
1989
27
Keratoconjunctivitis sicca in rheumatoid arthritis. (3246141)
1988
28
Keratoconjunctivitis sicca. (3393103)
1988
29
Keratoconjunctivitis sicca in patients with primary SjAPgren's syndrome. A longitudinal study of ocular parameters. (3218469)
1988
30
Beneficial effect of topical fibronectin in patients with keratoconjunctivitis sicca of SjAPgren's syndrome. (4045849)
1985
31
Possible drug-induced keratoconjunctivitis sicca in a dog. (4060547)
1985
32
Keratoconjunctivitis sicca in the dog associated with the administration of salicylazosulphapyridine (sulphasalazine). (2860750)
1985
33
Tear film osmolarity and keratoconjunctivitis sicca. (4042314)
1985
34
Keratoconjunctivitis sicca--an autoimmune condition? (4090224)
1985
35
Association of rosacea and keratoconjunctivitis sicca. (6231013)
1984
36
Keratoconjunctivitis sicca following instillation of gentian violet. (7141584)
1982
37
Studies on the treatment of keratoconjunctivitis sicca. (155979)
1979
38
Letter: Keratoconjunctivitis sicca after lacrimal gland removal. (1267648)
1976
39
Surgical induction of keratoconjunctivitis sicca in the dog. (4837826)
1974
40
Tear volume in normal eyes and keratoconjunctivitis sicca. (4548323)
1974
41
Keratoconjunctivitis sicca in dogs. (5104964)
1971
42
Keratoconjunctivitis sicca in the dog and its treatment. (5103374)
1971
43
Computer-assisted diagnosis in keratoconjunctivitis sicca. (4947706)
1971
44
THE RESPONSE OF THE LACRIMAL GLAND TO PARASYMPATHICOMIMETICS IN KERATOCONJUNCTIVITIS SICCA. (14167876)
1964
45
On the excretion of inorganic phosphorus in tears in keratoconjunctivitis sicca (13864385)
1962
46
Keratoconjunctivitis sicca and the collagen diseases. (13355946)
1956
47
Pulmonary infection in SjAPgren's disease (keratoconjunctivitis sicca): a report of a fatal case. (13264875)
1955
48
Congenital alacrimia and keratoconjunctivitis sicca in children. (13217790)
1954
49
Keratoconjunctivitis sicca; a review with a survey of 121 additional cases. (15405338)
1950
50
Keratoconjunctivitis sicca and chronic polyarthritis. (18881103)
1948

Genetic Variations for Keratoconjunctivitis Sicca

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Expression for genes affiliated with Keratoconjunctivitis Sicca

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratoconjunctivitis Sicca

Search GEO for disease gene expression data for Keratoconjunctivitis Sicca.

Pathways for genes affiliated with Keratoconjunctivitis Sicca

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29KEGG, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7LYZ, AQP5
29.0IL1A, IL4
39.0IL1A, IL4
4
Hide members
8.5IL1A, IL4, CD79A

Compounds for genes affiliated with Keratoconjunctivitis Sicca

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1glutamate4410.6NRTN
2suramin44 28 1112.6CFTR
3norepinephrine44 11 2412.3CFTR, LTF
4thapsigargin44 5911.2HSPG2, CFTR
5carbachol44 28 1111.8HSPG2, CD79A, CFTR
6cellulose triacetate449.8LTF, IL1A
7hypothiocyanite44 2410.7CD79A, LTF
8fluoride449.7HSPG2, CD79A, CFTR
9atropine44 28 1111.6HSPG2, NGF, LTF
10c2ceramide449.6HSPG2, LTF, NGF
11n-formylmethionyl-leucylphenylalanine449.6IL1A, LTF, HSPG2
12capsaicin44 2810.5CFTR, NGF, LTF, HSPG2
13propranolol44 28 49 11 2413.4NGF, LTF, HSPG2
14acetylcholine44 49 28 11 2413.4CFTR, NGF, NRTN, HSPG2
15pilocarpine44 28 1111.4CD79A, CFTR, AQP5, HSPG2
16oxazolone449.4IL1A, IL4
17h2o2449.4CD79A, CFTR, HSPG2, LTF
18phenylephrine44 28 11 2412.2HSPG2, NGF, IL1A
19neomycin449.2NGF, HSPG2, IL1A
20hypoxanthine44 11 2411.2NGF, IL4, LTF
21methacholine44 1110.2LTF, IL4, CD79A
22polymyxin b449.1LTF, IL1A, IL4
23prostacyclin449.1NGF, IL1A, LTF, HSPG2
24glycerol44 11 2411.1CFTR, CD79A, AQP5, NGF
25pentoxifylline44 1110.0LTF, IL4, IL1A
26ascorbic acid44 249.8IL1A, HSPG2, CFTR, CD79A, LTF
27glutamine448.8NGF, HSPG2, LTF, CFTR, IL1A
28isoproterenol44 119.8LTF, IL4, CFTR, IL1A
29ivig448.8IL1A, CD79A, IL4
30n acetylcysteine448.8CD79A, IL4, LTF, CFTR
31epinephrine44 11 2410.8CD79A, IL1A, CFTR, NGF
32heparin44 28 11 2411.8NRTN, HSPG2, LTF, CD79A, IL1A
33azathioprine44 49 2 1111.7IL4, CD79A, LTF, NGF
34chloroquine44 2 49 28 1112.7CD79A, IL4, CFTR
35biotin44 11 2410.7CD79A, CFTR, NGF, IL4
36phosphatidylcholine448.7IL1A, CD79A, NGF, HSPG2, LTF
37neopterin448.6IL4, LTF, CD79A, IL1A
38vitamin d448.6CFTR, NGF, CD79A, IL1A
39herbimycin a44 599.6IL1A, IL4, NGF, HSPG2
40adenylate448.6NGF, LTF, HSPG2, CFTR, IL4
41pdtc448.5NGF, IL4, IL1A
42histamine44 28 2410.4HSPG2, LTF, NGF, CD79A, IL4
43aspirin44 49 28 2411.4IL4, CFTR, NGF, HSPG2, CD79A
44actinomycin d448.3CFTR, IL1A, IL4, NGF, LTF
45polyethylene glycol448.2CD79A, IL1A, IL4
46retinoic acid44 249.0CD79A, IL1A, NGF, LTF, NRTN, HSPG2
47cyclosporin a44 28 599.8CFTR, NGF, LTF, CD79A, IL1A, IL4
48vegf447.8IL1A, HSPG2, LTF, NGF, CD79A, IL4
49indomethacin44 59 28 1110.5CFTR, CD79A, IL4, IL1A, LTF, HSPG2
50dexamethasone44 49 28 1110.5IL1A, HSPG2, LTF, IL4, CD79A, CFTR

GO Terms for genes affiliated with Keratoconjunctivitis Sicca

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16Gene Ontology
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Cellular components related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.8LYZ, IL1A, IL4, NGF, HSPG2
2extracellular regionGO:0055767.7LYZ, HSPG2, NRTN, LTF, NGF, IL1A

Molecular functions related to Keratoconjunctivitis Sicca according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080838.8IL4, NGF, NRTN

Products for genes affiliated with Keratoconjunctivitis Sicca

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Sources for Keratoconjunctivitis Sicca

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet