MCID: KRT007
MIFTS: 43

Keratoconus malady

Categories: Genetic diseases, Rare diseases, Eye diseases

Aliases & Classifications for Keratoconus

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Aliases & Descriptions for Keratoconus:

Name: Keratoconus 32 10 45 47 12 36 65
Noninflammatory Corneal Thining 45
Keratoconjunctivitis Sicca 65
 
Conical Cornea 10
Kc 45

Classifications:



External Ids:

Disease Ontology10 DOID:10126
ICD1027 H18.6, H18.60
ICD9CM29 371.6, 371.60
MeSH36 D007640
NCIt42 C26806
UMLS65 C0022578

Summaries for Keratoconus

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NIH Rare Diseases:45 Keratoconus is the degeneration of the structure of the cornea, which is the clear tissue covering the front of the eye. in this condition, the shape of the cornea slowly changes from the normal round shape to a cone shape. most people who develop keratoconus start out nearsighted, which tends to become worse over time. the earliest symptom is a slight blurring of vision that cannot be corrected with glasses. over time, there may be eye halos, glare, or other night vision problems.the cause is unknown, but the tendency to develop keratoconus is probably present from birth. keratoconus is thought to involve a defect in collagen, the tissue that makes up most of the cornea. some researchers believe that allergy and eye rubbing may play a role. treatment for keratoconus depends on the severity of your condition and how quickly the condition is progressing. mild to moderate keratoconus can be treated with eyeglasses or contact lenses. in some people the cornea becomes scarred or wearing contact lenses becomes difficult. in these cases, surgery might be necessary. last updated: 3/23/2016

MalaCards based summary: Keratoconus, also known as noninflammatory corneal thining, is related to acute hydrops keratoconus and ehlers-danlos syndrome, type vi. An important gene associated with Keratoconus is VSX1 (Visual System Homeobox 1), and among its related pathways is Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). Affiliated tissues include eye, breast and liver, and related mouse phenotype vision/eye.

Disease Ontology:10 A corneal disease characterized by structural changes within the cornea causing it to thin and change, leading to a protruding conical shape.

Wikipedia:68 Keratoconus (KC, KTCN) is a degenerative disorder of the eye in which structural changes within the... more...

Related Diseases for Keratoconus

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Diseases in the Keratoconus family:

Keratoconus 4 Keratoconus 3
Keratoconus 5 Keratoconus 6
Keratoconus 7 Keratoconus 8
Keratoconus 2 Keratoconus 1

Diseases related to Keratoconus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 562)
idRelated DiseaseScoreTop Affiliating Genes
1acute hydrops keratoconus33.2COL8A2, KERA, KRT3, VSX1, ZNF469
2ehlers-danlos syndrome, type vi30.7PRDM5, ZNF469
3leukemia30.6AIPL1, CRB1, CRX, GUCY2D
4cervicitis30.2COL8A2, KRT3, VSX1
5influenza29.8AIPL1, CRB1, CRX, GUCY2D
6keratoconus 112.5
7keratoconus 512.4
8keratoconus 612.4
9keratoconus 712.4
10keratoconus 812.4
11keratoconus 412.3
12keratoconus 312.3
13keratoconus 212.3
14stable condition keratoconus12.3
15keratoconus posticus circumscriptus12.3
16mental retardation, keratoconus, febrile seizures, and sinoatrial block12.2
17keratoconjunctivitis sicca11.7
18edict syndrome11.4
19kenny-caffey syndrome, type 111.3
20dry eye syndrome10.5
21corneal dystrophy, posterior polymorphous, 110.5VSX1, ZNF469
22aipl1-related retinitis pigmentosa10.4AIPL1, GUCY2D
23pseudopapilledema10.4PRDM5, VSX1
24lymphoproliferative syndrome, x-linked, 210.4COL8A2, VSX1
25leber congenital amaurosis 210.3
26leber congenital amaurosis 810.3
27leber congenital amaurosis 1110.3
28leber congenital amaurosis 610.3
29brittle cornea syndrome 110.3
30leber congenital amaurosis 110.3
31leber congenital amaurosis 710.3
32rpe65-related retinitis pigmentosa10.3AIPL1, CRX, GUCY2D
33aspergillosis10.3
34thyroiditis10.3
35andersen syndrome10.3CRB1, CRX, GUCY2D
36obesity10.2
37endotheliitis10.2
38breast cancer10.2
39hepatitis10.2
40lupus erythematosus10.2
41leber congenital amaurosis 910.2
42leber congenital amaurosis 1210.2
43leber congenital amaurosis 1610.2
44brittle cornea syndrome 210.2
45leber congenital amaurosis 1410.2
46leber congenital amaurosis 1510.2
47retinitis pigmentosa 7 and digenic10.2
48leber congenital amaurosis 510.2
49leber congenital amaurosis 1710.2
50leber congenital amaurosis 1010.2

Graphical network of the top 20 diseases related to Keratoconus:



Diseases related to keratoconus

Symptoms for Keratoconus

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Drugs & Therapeutics for Keratoconus

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Drugs for Keratoconus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 85)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Moxifloxacinapproved, investigationalPhase 4, Phase 1409354812-41-2152946
Synonyms:
(1'S,6'S)-1-Cyclopropyl-7-(2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4aS,7aS)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid
1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4as,7as)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid
151096-09-2
186826-86-8
192927-63-2
7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid
AC1L49EP
Actira (*Hydrochloride*)
Avelox
Avelox (*Hydrochloride*)
Avelox I.V.
BAY 12-8039
BAY 12-8039 (*Hydrochloride*)
 
CCRIS 8690
CHEMBL32
CID152946
DB00218
I06-1961
LS-141510
MFX
MXF
MXFX
Moxeza
Moxifloxacin
Moxifloxacin Hydrochloride
Moxifloxacin [INN:BAN]
UNII-U188XYD42P
Vigamox
moxifloxacin
2
PrednisoloneapprovedPhase 4, Phase 1108250-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
Flo-pred
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
MLS001304083
 
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
Millipred
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Omnipred
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
3
MethylprednisoloneapprovedPhase 4, Phase 1108283-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
A-methapred
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Depo-medrol
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Solu-medrol
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
4
FluorometholoneapprovedPhase 417426-13-19878
Synonyms:
(1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11beta,17alpha-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione
426-13-1
9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11-beta,17-dihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
AC-3520
AC1L1U0Y
AI3-52813
Alcon Brand of Fluorometholone
Allergan Brand 1 of Fluorometholone
Allergan Brand 2 of Fluorometholone
Allergan Brand 3 of Fluorometholone
BPBio1_001029
BRD-K64862097-001-03-9
BSPBio_000935
CHEMBL1200600
CID9878
Cortilet
Cortisdin
D005469
D01367
DB00324
Delmeson
EINECS 207-041-5
Efflumidex
F0414
F9381_SIGMA
FML
FML Forte
FML Liquifilm
FML S.O.P
FML-S Liquifilm
Flarex
Fluaton
Flucon
Flucon, Isopto
Flumetholon
Fluor Op
Fluor-OP
Fluor-Op
Fluor-op (TN)
Fluormetholon
Fluormetholone
Fluormetholonum
Fluoro Ophtal
Fluoro-Ophtal
Fluoromethalone
Fluorometholon
Fluorometholone
Fluorometholone (JP15/USP/INN)
 
Fluorometholone Acetate
Fluorometholone [INN:BAN:JAN]
Fluorometholonum
Fluorometholonum [INN-Latin]
Fluorometolona
Fluorometolona [INN-Spanish]
Fluorometolone
Fluorometolone [DCIT]
Fluorométholone
Fluoropos
Fml
Fml (TN)
Fml Forte
HMS1570O17
Isdin Brand of Fluorometholone
Isopto Flucon
LS-118455
Loticort
MLS000069537
MLS001076157
MolPort-003-941-413
NCGC00021575-03
NCI60_002886
NSC 33001
NSC-33001
NSC33001
Neo-Oxylone
Novartis Brand of Fluorometholone
Oxylone
Oxylone (TN)
PMS Fluorometholone
PMS-Fluorometholone
Pharm Allergan Brand of Fluorometholone
Pharm-Allergan Brand of Fluorometholone
Pharmascience Brand of Fluorometholone
Pregna-1,4-diene-3,20-dione, 9-fluoro-11.beta.,17
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17-dihydroxy-6alpha-methyl- (8CI)
Prestwick0_000718
Prestwick1_000718
Prestwick2_000718
Prestwick3_000718
Prestwick_227
SMR000058598
SPBio_002856
Trilcin
U 8614
UNII-SV0CSG527L
Ursapharm Brand of Fluorometholone
Ursnon
Winzer Brand of Fluorometholone
ZINC03876158
component of Neo-Oxylone
fluorometholone
5
DiclofenacapprovedPhase 427315307-86-53033
Synonyms:
(2,6-Dichlorophenyl)amino]benzeneacetic acid
15307-81-0 (mono-potassium salt)
15307-86-5
2-((2,6-Dichlorophenyl)amino)benzeneacetic acid
2-(2,6-Dichloroanilino)phenylacetic Acid
2-(2,6-Dichlorophenylamino)phenylacetic acid
2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid
2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID
2-[2-(2,6-Dichlorophenylamino)phenyl]acetic acid
2-[2-(2,6-dichloroanilino)phenyl]acetic acid
2b17
AC1L1F0T
AKOS001579542
Acetic acid, [o-(2,6-dichloroanilino)phenyl]- (8CI)
Allvoran
Apo-Diclo
Assaren
BIDD:GT0380
BPBio1_000516
BRD-K08252256-236-05-6
BRN 2146636
BSPBio_000468
BSPBio_002169
Benfofen
Benzeneacetic acid, 2-((2,6-dichlorophenyl)amino)- (9CI)
C01690
CHEBI:47381
CHEMBL139
CID3033
Cambia
Cataflam
D07816
D30801
D3748
DB00586
DIF
Delphimix
Dichlofenac
Dichlofenal
Dichronic
Diclac
Diclo-Phlogont
Diclo-Puren
Diclobenin
Diclofenac
Diclofenac (INN)
Diclofenac Acid
Diclofenac Potassium
Diclofenac Sodium
Diclofenac [INN:BAN]
Diclofenac acid
Diclofenac potassium
Diclofenac sodium
Diclofenaco
Diclofenaco [INN-Spanish]
Diclofenacum
Diclofenacum [INN-Latin]
Diclofenamic acid
Diclomelan
Diclonate P
Diclophenac
Diclord
Dicloreum
Dicloreuma
Dicrofenac
DivK1c_000272
DivK1c_000402
Dolobasan
Duravolten
Dyloject
EINECS 239-348-5
Ecofenac
Effekton
Flector
GP-45,840
HMS2090C10
HMS501E04
HSDB 7234
 
I14-7739
IDI1_000272
IDI1_000402
ISV-205
KBio1_000272
KBio1_000402
KBio2_001410
KBio2_002306
KBio2_003978
KBio2_004874
KBio2_006546
KBio2_007442
KBio3_001389
KBio3_002786
KBioGR_001051
KBioGR_002306
KBioSS_001410
KBioSS_002308
Kriplex
LS-11575
Lopac0_000441
MolPort-000-003-072
N-(2,6-Dichlorop
NCGC00021125-01
NINDS_000272
NINDS_000402
Neriodin
Novapirina
Novo-Difenac
Novo-Difenac SR
Nu-Diclo
Oprea1_011155
Orthofen
Pennsaid
Prestwick0_000594
Prestwick1_000594
Prestwick2_000594
Prestwick3_000594
Primofenac
ProSorb-D
Prophenatin
Rhumalgan
SBB068617
SPBio_001081
SPBio_002687
SR-38
STK984493
Solaraze
Solaraze (TN)
Solaraze T
Spectrum2_000991
Spectrum3_000385
Spectrum4_000506
Spectrum5_000867
Spectrum_000930
Transfenac
Tsudohmin
UNII-144O8QL0L1
UNM000001216103
Valetan
Voldal
Voltaflan
Voltaren
Voltaren Ophtha
Voltaren Ophthalmic
Voltaren Rapide
Voltaren SR
Voltaren ophthalmic
Voltaren-XR
Voltarol
Xenid
Zipsor
Zorvolex
[2-(2,6-Dichloroanilino)phenyl]acetic acid
[o-(2,6-Dichloroanilino)phenyl]acetic acid
cMAP_000014
dichlofenac
diclofenac
henyl)-o-aminophenylacetic acid
{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
6
KetorolacapprovedPhase 427866635-83-43826
Synonyms:
(+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
(+-)-Ketorolac
(+-)-isomer
(.+/-.)-2,3-Dihydro-5-benzoyl-1H-pyrrolizine-1-carboxylic acid
1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro
5-(phenylcarbonyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
5-Benzoyl-1,2-dihydro-3H-pyrrolo(1,2a)pyrrole-1-carboxylic acid
5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
66635-83-4
74103-06-3
AB00053682
AC-545
AC1L1GSW
Acular
Acuvail
BRD-A40639672-234-05-7
C07062
CHEBI:105080
CHEMBL469
CID3826
D020910
D08104
DB00465
 
I14-2832
Ketoralac
Ketorolac
Ketorolac (INN)
Ketorolac Tromethamine
Ketorolac [INN:BAN]
Ketorolaco
Ketorolaco [Spanish]
Ketorolacum
Ketorolacum [Latin]
Kétorolac
LS-139094
Macril
MolPort-005-933-093
NCGC00185990-01
RS 37619
RS-37619
SBB067312
STL018674
Sprix
Toradol (TN)
UNII-YZI5105V0L
ketorolac
rac-Ketorolac
7
RanibizumabapprovedPhase 4460347396-82-1459903
Synonyms:
347396-82-1
D05697
Lucentis
Lucentis (TN)
 
Ranibizumab
Ranibizumab (USAN/INN)
Ranibizumab (genetical recombination)
Ranibizumab (genetical recombination) (JAN)
ranibizumab
rhuFab V2
8
Riboflavinapproved, nutraceuticalPhase 4, Phase 2, Phase 3, Phase 115083-88-5493570
Synonyms:
(-)-Riboflavin
1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-D-ribitol
1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
6,7-Dimethyl-9-D-ribitylisoalloxazine
6,7-Dimethyl-9-ribitylisoalloxazine
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-Benzo[g]pteridine-2,4(3H,10H)-dione
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
7,8-Dimethyl-10-ribitylisoalloxazine
Beflavin
Beflavine
Benzo[g]pteridine riboflavin deriv.
E 101
Flavaxin
Flavin BB
Flaxain
Food Yellow 15
Hyre
Lactobene
 
Lactoflavin
Lactoflavine
Ribipca
Ribocrisina
Riboderm
Riboflavin
Riboflavin phosphate sodium dihydrate
Riboflavina
Riboflavine
Riboflavinum
Ribosyn
Ribotone
Ribovel
Russupteridine yellow III
San Yellow B
Vitaflavine
Vitamin B2
Vitamin G
Vitasan B2
e101
9
Folic Acidapproved, nutraceuticalPhase 4, Phase 2, Phase 3, Phase 1292459-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic Acid
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
 
Folsaeure
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
10
Flavin MononucleotideexperimentalPhase 4, Phase 2, Phase 36146-17-85702760, 643976
Synonyms:
FMN
Flanin
Flavine mononucleotide
Flavol
Riboflavin
Riboflavin 5'-monophosphate
Riboflavin 5'-phosphate
Riboflavin Mononucleotide
Riboflavin monophosphate
 
Riboflavin phosphate
Riboflavin-5'-phosphate na
Riboflavin-5-phosphate
Riboflavine 5'-monophosphate
Riboflavine 5'-phosphate
Riboflavine dihydrogen phosphate
Riboflavine monophosphate
Riboflavine phosphate
Riboflavine-5'-phosphate
Vitamin B2 phosphate
11
Bromfenacapproved, Approved July 1997Phase 44191714-94-260726
Synonyms:
2-Amino-3-(4-bromobenzoyl)benzeneacetic acid
2-[2-amino-3-(4-bromobenzoyl)phenyl]acetic acid
2-amino-3-(4-Bromobenzoyl)benzeneacetic acid
91714-94-2
AC1L1TSW
AC1Q5DQ7
AHR-10282
Ambap120638-55-3
BROMFENAC SODIUM
Bromday
Bromfenac
Bromfenac (INN)
Bromfenac [INN]
Bromfenac sodium
Bromfenaco
Bromfenaco [Spanish]
 
Bromfenacum
Bromfenacum [Latin]
C15H12BrNO3
CHEBI:240107
CHEMBL1077
CID60726
D07541
DB00963
Duract
LS-178156
MolPort-000-883-091
Prolensa
UNII-864P0921DW
Xibrom
[2-Amino-3-(4-bromo-benzoyl)-phenyl]-acetic acid
[2-amino-3-(4-bromobenzoyl)phenyl]acetic acid
sodium 2-amino-3-(4-bromobenzoyl) phenylacetate sesquihydrate
{2-amino-3-[(4-bromophenyl)carbonyl]phenyl}acetic acid
12Norgestimate, ethinyl estradiol drug combinationPhase 4, Phase 1409
13Methylprednisolone acetatePhase 4, Phase 11082
14Prednisolone acetatePhase 4, Phase 11082
15HormonesPhase 411748
16Peripheral Nervous System AgentsPhase 418510
17Prednisolone hemisuccinatePhase 4, Phase 11082
18DextransPhase 4, Phase 2, Phase 3, Phase 172
19Pharmaceutical SolutionsPhase 4, Phase 3, Phase 2, Phase 17004
20MicronutrientsPhase 4, Phase 2, Phase 3, Phase 13901
21Dermatologic AgentsPhase 4, Phase 2, Phase 3, Phase 14555
22TetrahydrozolinePhase 4, Phase 2, Phase 3542
23Photosensitizing AgentsPhase 4, Phase 2, Phase 3, Phase 1374
24Trace ElementsPhase 4, Phase 2, Phase 3, Phase 13900
25Methylprednisolone HemisuccinatePhase 4, Phase 11082
26VitaminsPhase 4, Phase 2, Phase 3, Phase 13857
27Ophthalmic SolutionsPhase 4, Phase 2, Phase 3, Phase 11006
28Vitamin B ComplexPhase 4, Phase 2, Phase 3, Phase 12847
29Prednisolone phosphatePhase 4, Phase 11082
30Protective AgentsPhase 45651
31Neuroprotective AgentsPhase 41376
32Gastrointestinal AgentsPhase 46401
33Antineoplastic Agents, HormonalPhase 44256
34Anti-Inflammatory AgentsPhase 48478
35AntiemeticsPhase 43213
36Ketorolac TromethaminePhase 4278
37glucocorticoidsPhase 43896
38Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 49988
39Hormone AntagonistsPhase 410002
40Immunologic FactorsPhase 418483
41Angiogenesis InhibitorsPhase 43688
42Angiogenesis Modulating AgentsPhase 43611
43Vitamin B9NutraceuticalPhase 4, Phase 2, Phase 3, Phase 12924
44FolateNutraceuticalPhase 4, Phase 2, Phase 3, Phase 12924
45Vitamin B2NutraceuticalPhase 4, Phase 2, Phase 3, Phase 1150
46
DipivefrinapprovedPhase 38452365-63-63105
Synonyms:
( -)-2,2-Dimethylpropansaeure-4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylenester
( -)-4-(1-Hydroxy-2-methylaminoethyl)-o-phenylendipivalat
(+-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol 3,4-dipivalate
(+-)-4-[1-Hydroxy-2-(methylamino)ethyl]-O-phenylene divavalate
(+-)-4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalate
(RS)-4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-phenylen dipivalat
1-(3',4'-Dipivaloyloxyphenyl)-2-methylamino-1-ethanol
1-(3',4'-dipivaloyloxyphenyl)-2-methylamino-1-ethanol
2,2-Dimethylpropanoic acid 4-[1-hydroxy-2-(methylamino)ethyl]-1,2-phenylene ester
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-phenylen dipivalat
4-[1-Hydroxy-2-(methylamino)ethyl]-O-phenylene divavalate
4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalate
4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diyl bis(2,2-dimethylpropanoate)
52365-63-6
AB00514686
AC1L1F6K
AKOS003662293
AKPro
BPBio1_000688
BRD-A47494775-003-03-0
BSPBio_000624
C06963
C19H29NO5
CHEBI:4646
CID3105
D02349
DB00449
Dipivalyl Epinephrine
 
Dipivefrin
Dipivefrin (USAN)
Dipivefrin HCL
Dipivefrin Hydrochloride
Dipivefrin [USAN]
Dipivefrina
Dipivefrina [INN-Spanish]
Dipivefrine
Dipivefrine (INN)
Dipivefrinum
Dipivefrinum [INN-Latin]
Dipivéfrine
K 30081
L000915
LS-121419
NCGC00179499-01
Ophtho-Dipivefrin
Prestwick0_000632
Prestwick1_000632
Prestwick2_000632
Prestwick3_000632
Pro-Epinephrine
Propine
Propine C Cap B.I.D.
SPBio_002843
UNII-8Q1PVL543G
[2-(2,2-dimethylpropanoyloxy)-4-[1-hydroxy-2-(methylamino)ethyl]phenyl] 2,2-dimethylpropanoate
dipivalyl epinephrine
dipivefrin
nchembio747-comp3
47
LidocaineapprovedPhase 2, Phase 31103137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Afterburn
Akten
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bikini Zone Medicated
Bikini Zone Medicated Creme
Bio-0767
Bio-scriptives Lidum
Bio-scriptives Lidum Hemorroidal (anorectal)
Bio-scriptives Lidum Topical Analgesic
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
Burn Relief Leader
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Comfortcaine
Cuivasil
Curacaine Transdermal Corporation
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
Derma Numb
DermaFlex
Desert Harvest Releveum
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Dr. Numb
Dr. Richs Numbing
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gigi Anesthetic Numbing
Gravocain
H-releve Hemorrhoidal
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
Hawaiian Tropic
Hush Anesthetic
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
LS-805
Lanabiotic
 
Laryng-o-jet
Leostesin
Lida-Mantle
Lidall
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine 4% Cream
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Hydrochloride
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocaine hydrochloride
Lidocainum
Lidocainum [INN-Latin]
Lidocare Mist
Lidocaton
Lidocream 4
Lidocream 5
Lidoderm
Lidoderm 5
Lidoject-1
Lidoject-2
Lifestyles Epic Male Genital Desensitizer
Lignocaine
Lignocainum
Lingocaine
Lmx4
Lmx5
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Numb Master Topical Anesthetic
Numb Nuts
Ocean Potion Instant Burn Relief Ice
Octocaine
Octocaine-100
Octocaine-50
Plum Smooth Plumb Numb Gelee
Premjact Male Desensitizer Pound International
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Recticare
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Simplicity Desensitizing
Simply Numb Endure
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Sole Serum
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Walgreens Aloe Vera Pain Relieving
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocaine-mpf
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zcaine Fast Acting Anesthetic
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
48MitomycinsPhase 3219
49Anti-Bacterial AgentsPhase 3, Phase 19140
50AnestheticsPhase 3, Phase 27385

Interventional clinical trials:

(show top 50)    (show all 124)
idNameStatusNCT IDPhase
1Effect of CACICOL20 on Corneal Epithelial Healing After Cross-linking in Patients With KeratoconusCompletedNCT02119039Phase 4
2Relationship Between Central Corneal Thickness and Intraocular Pressure Measures Instruments.CompletedNCT00347191Phase 4
3Intrastromal Corneal Ring Segment Implantation in 219 Keratoconic Eyes at Different StagesCompletedNCT01261013Phase 4
4Corneal Thickness Changes During Corneal Collagen Cross-linking With Ultraviolet-A Irradiation and RiboflavinCompletedNCT01485211Phase 4
5Intrastromal Corneal Ring for High Astigmatism on PostkeratoplastyCompletedNCT01018797Phase 4
6CXL-04 A Study of Collagen Crosslinking With Ultraviolet-A in Asymmetric CorneasRecruitingNCT01956474Phase 4
7Collagen Crosslinking With Ultraviolet-A in Asymmetric CorneasRecruitingNCT01024322Phase 4
8Transepithelial Corneal Cross-linking Using IontophoresisActive, not recruitingNCT02117999Phase 4
9Evaluation of Changes in the Parameters of Optical Coherence Tomography After Intravitreal Injection of LucentisNot yet recruitingNCT01669447Phase 4
10Riboflavin Mediated Corneal Crosslinking for Stabilizing Progression of KeratoconusCompletedNCT00626717Phase 2, Phase 3
11Corneal Sensitivity Cross-linking KeratoconusCompletedNCT01743443Phase 2, Phase 3
12Corneal Collagen Cross-linking for Progressive KeratoconusCompletedNCT00647699Phase 3
13Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal EctasiaCompletedNCT00567671Phase 2, Phase 3
14Deep Anterior Lamellar Keratoplasty (DALK)CompletedNCT00887900Phase 3
15Non-inferiority Trial of Iontophoretic Corneal Collagen Crosslinking (CXL) Compared to Standard Corneal Collagen Crosslinking in Progressive Keratoconus.RecruitingNCT01868620Phase 3
16Safety and Effectiveness of Collagen Cross Linking in Progressive Mild and Moderate KeratoconusRecruitingNCT00815256Phase 3
17Treatment of Keratoconus Using Collagen Cross-LinkingRecruitingNCT00841386Phase 2, Phase 3
18Microwave Treatment and Corneal Collagen Crosslinking for KeratoconusRecruitingNCT01672814Phase 3
19Corneal Collagen Crosslinking and Intacs for Keratoconus and EctasiaRecruitingNCT01112072Phase 3
20Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical TrialRecruitingNCT01604135Phase 3
21Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal EctasiaRecruitingNCT01464268Phase 3
22Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic RiboflavinRecruitingNCT01152541Phase 3
23Evaluating the Safety and Efficacy of the KXL System for Corneal Collagen Cross-Linking in Eyes Having KeratoconusRecruitingNCT02638376Phase 3
24Collagen Cross-Linking for Keratoconus/Ectasia With and Without IntacsRecruitingNCT01081561Phase 2, Phase 3
25The Effects of Corneal Collagen Cross-linkingRecruitingNCT01708538Phase 3
26Evaluating Collagen Cross-Linking (CCL) Treatment in NorwayRecruitingNCT00435799Phase 2, Phase 3
27A Multi-Center, Randomized, Placebo-Controlled Evaluation of the Safety and Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With KeratoconusActive, not recruitingNCT01972854Phase 3
28Comparison of Penetrating Keratoplasty and Deep Lamellar Keratoplasty With the Big Bubble Technique for KeratoconusActive, not recruitingNCT00371202Phase 3
29Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With KeratoconusActive, not recruitingNCT01643226Phase 3
30Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With KeratoconusActive, not recruitingNCT01344187Phase 3
31Corneal Cross Linking and Topography Guided Excimer Laser TreatmentActive, not recruitingNCT01682993Phase 3
32Refractive Treatment of Early KeratoconusNot yet recruitingNCT02613780Phase 3
33Corneal Cross-Linking Comparing VariablesNot yet recruitingNCT02095730Phase 3
34Safety Study of the VEGA UV-A System to Treat KeratoconusTerminatedNCT01190306Phase 3
35Safety and Effectiveness Study of the VEGA UV-A System for Cross-linking in Eyes With Keratoconus and EctasiaTerminatedNCT01398852Phase 3
36A Multi-Center, Randomized, Controlled Evaluation of the Safety and Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive SurgeryTerminatedNCT01459679Phase 3
37Corneal Crosslinking in Keratoconus and Corneal EctasiaWithdrawnNCT00679666Phase 2, Phase 3
38Transepithelial Corneal Collagen Cross-linking (CXL) in Treatment of KeratoconusCompletedNCT01181219Phase 2
39Comparison of Partial Removal and Total Removal of the Corneal Epithelium on KeratoconusCompletedNCT01809977Phase 2
40Lamellar Transplant With Lyophilized CorneasCompletedNCT00409955Phase 2
41Measurement of High Order Aberrations in Late Stages KeratoconusRecruitingNCT01295164Phase 1, Phase 2
42Corneal Crosslinking in Patients With Keratoconus and Post-Refractive EctasiaRecruitingNCT01143389Phase 2
43Myoring Versus Keraring Implantation for KeratoconusRecruitingNCT01869517Phase 2
44Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot StudyRecruitingNCT01843101Phase 2
45UVA-Riboflavin Crosslinking Treatment of Corneal EctasiaRecruitingNCT01325298Phase 2
46Treatment of Keratoconus With Advanced Corneal CrosslinkingActive, not recruitingNCT02425150Phase 2
47Treatment of Keratoconus With Advanced CXL-IIActive, not recruitingNCT02514200Phase 2
48Adapted Fluence Settings for Corneal Collagen Cross-linking in Mild to Moderate Progressive KeratoconusActive, not recruitingNCT02507362Phase 1, Phase 2
49Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking for Compassionate Treatment in Pediatric Patients With Progressive KeratoconusNot yet recruitingNCT00925327Phase 2
50Safety and Effectiveness of the RHCIII-MPC Biosynthetic Cornea in Patients Requiring Anterior Lamellar KeratoplastyNot yet recruitingNCT02424006Phase 1, Phase 2

Search NIH Clinical Center for Keratoconus


Cochrane evidence based reviews: keratoconus

Genetic Tests for Keratoconus

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Anatomical Context for Keratoconus

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MalaCards organs/tissues related to Keratoconus:

33
Eye, Breast, Liver, Thyroid, Testes, Endothelial, Bone

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Keratoconus:
id TissueAnatomical CompartmentCell Relevance
1 EyeCorneal StromaKeratocytes Affected by disease

Animal Models for Keratoconus or affiliated genes

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MGI Mouse Phenotypes related to Keratoconus:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.1AIPL1, COL8A2, CRB1, CRX, GUCY2D, KERA

Publications for Keratoconus

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Articles related to Keratoconus:

(show top 50)    (show all 755)
idTitleAuthorsYear
1
Hepatitis A Virus Genotype Distribution during a Decade of Universal Vaccination of Preadolescents. (25815599)
2015
2
MKAN27435 Is Required for the Biosynthesis of Higher Subclasses of Lipooligosaccharides in Mycobacterium kansasii. (25893968)
2015
3
Severe gastrointestinal dysmotility developed after treatment with gonadotropin-releasing hormone analogs. (25592315)
2015
4
Notch1 promotes hepatitis B virus X protein-induced hepatocarcinogenesis via Wnt/I^-catenin pathway. (25017705)
2014
5
Complicated Clostridium difficile colitis in children with cystic fibrosis: Association with gastric acid suppression? (23993432)
2014
6
Natural antiband 3 antibodies in patients with sickle cell disease. (23643401)
2013
7
Acylated ghrelin: a potential marker for fibromyalgia? (23475812)
2013
8
Pyoderma gangrenosum in a newborn - case report. (24346911)
2013
9
NK cells: a double-edged sword in chronic hepatitis B virus infection. (23459859)
2013
10
Continuity of outpatient treatment after discharge of patients with major depressive disorder. (23686160)
2013
11
Management of intravascular leiomyomatosis: laparoscopic surgery for ordinary uterine fibroids led to an extraordinary finding. (23454251)
2013
12
Changes in interictal spike features precede the onset of temporal lobe epilepsy. (22718546)
2012
13
BDKRB2 +9/-9 polymorphism is associated with higher risk for diabetes mellitus in the Brazilian general population. (23243416)
2012
14
Evaluation of cyclin-dependent kinase-like 1 expression in breast cancer tissues and its regulation in cancer cell growth. (22804458)
2012
15
Plantar fasciitis. Focus on the basics. (23045740)
2012
16
Evaluation of calcium, magnesium, potassium, and sodium in biological samples of Pakistani viral hepatitis (A-E) patients and controls. (21755830)
2011
17
Case Report of Suspected Rhabdomyolysis during Treatment with Trabectedin in a Patient with Metastatic Leiomyosarcoma. (21611101)
2010
18
Epigenetic regulation of the expression of genes involved in steroid hormone biosynthesis and action. (20156469)
2010
19
Canonical and noncanonical Wnt pathway: a comparison among normal ovary, benign ovarian tumor and ovarian cancer. (19148501)
2009
20
Cardiac metastasis in malignant fibrous histiocytoma. (18626538)
2008
21
Multiple-antigen immunization of chickens facilitates the generation of recombinant antibodies to autoantigens. (18062792)
2008
22
Three-Dimensional CT venography of varicose veins of the lower extremity: image quality and comparison with doppler sonography. (18806163)
2008
23
IL-2 withdrawal induces HTLV-1 expression through p38 activation in ATL cell lines. (17950728)
2007
24
Three-dimensional structure of heat shock protein 90 from Plasmodium falciparum: molecular modelling approach to rational drug design against malaria. (17536172)
2007
25
Neonatal intestinal volvulus due to a persistent right vitelline artery. (17024295)
2007
26
Prostanoid receptor expression by human airway smooth muscle cells and regulation of the secretion of granulocyte colony-stimulating factor. (15640521)
2005
27
Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6. (15781871)
2005
28
Expressional reprogramming of survival pathways in rat cardiocytes by neuregulin-1beta. (16036905)
2005
29
Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. (15488761)
2004
30
Evaluation of mRNA expression of estrogen receptor beta and its isoforms in human normal and neoplastic endometrium. (15170658)
2004
31
Copper induces histone hypoacetylation through directly inhibiting histone acetyltransferase activity. (15276868)
2004
32
The prognostic importance of urinase type plasminogen activators (uPA) and plasminogen activator inhibitors (PAI-1) in the primary resection of oral squamous cell carcinoma]. (15138855)
2004
33
Deformational posterior plagiocephaly: diagnosis and treatment. (12401104)
2002
34
ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2. (12221107)
2002
35
The thymus gland is a target in malnutrition. (12142962)
2002
36
Genes involved in implantation. (11545164)
2001
37
Hypoxia induces apoptosis in human neuroblastoma SK-N-MC cells by caspase activation accompanying cytochrome c release from mitochondria. (9849900)
1998
38
Treatment-induced mucositis: an old problem with new remedies. (9635851)
1998
39
Aortic atherosclerosis and stroke. (17894983)
1997
40
Experimental spondyloarthropathy in HLA-B27 transgenic rats. (8835497)
1996
41
1,1'-Ethylidenebis[L-tryptophan], an impurity in L-tryptophan associated with eosinophilia-myalgia syndrome, stimulates type I collagen gene expression in human fibroblasts in vitro. (8624499)
1995
42
Histamine induces a selective albumin permeation through the blood-brain barrier in vitro. (8521001)
1995
43
Effect of interleukin 1, lipopolysaccharide and phorbol esters on phospholipase D activity in chondrocytes. (11550712)
1994
44
Gastric liposarcoma: CT appearance. (8508081)
1993
45
Neuroimaging of the optic nerve after fenestration for management of pseudotumor cerebri. (1580839)
1992
46
Synthesis and turnover of proteoglycans by human and bovine adult articular chondrocytes cultured in alginate beads. (1603034)
1992
47
DNA content and estrogen receptors in primary carcinoma of the breast. (1714340)
1991
48
Natural course of clinically localized prostate adenocarcinoma in men less than 70 years old. (2056609)
1991
49
Mechanism of neutrophil activation by an unopsonized inflammatory particulate. Monosodium urate crystals induce pertussis toxin-insensitive hydrolysis of phosphatidylinositol 4,5-bisphosphate. (1645760)
1991
50
A comparative analysis of the clinical, sialographic, and pathologic findings in parotid disease. (4062061)
1985

Variations for Keratoconus

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Expression for genes affiliated with Keratoconus

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Search GEO for disease gene expression data for Keratoconus.

Pathways for genes affiliated with Keratoconus

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Pathways related to Keratoconus according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.7MMP1, MMP2

GO Terms for genes affiliated with Keratoconus

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Biological processes related to Keratoconus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:00305749.5COL8A2, MMP2
2extracellular matrix disassemblyGO:00226179.1COL8A2, MMP1, MMP2

Sources for Keratoconus

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet