KC
MCID: KRT007
MIFTS: 48

Keratoconus (KC) malady

Categories: Rare diseases, Eye diseases, Genetic diseases

Aliases & Classifications for Keratoconus

Aliases & Descriptions for Keratoconus:

Name: Keratoconus 38 12 50 52 42 14 69
Noninflammatory Corneal Thining 50
Conical Cornea 12
Kc 50

Classifications:



External Ids:

Disease Ontology 12 DOID:10126
ICD10 33 H18.6 H18.60
ICD9CM 35 371.6 371.60
MeSH 42 D007640
NCIt 47 C26806
UMLS 69 C0022578

Summaries for Keratoconus

NIH Rare Diseases : 50 keratoconus is the degeneration of the structure of the cornea, which is the clear tissue covering the front of the eye. in this condition, the shape of the cornea slowly changes from the normal round shape to a cone shape. most people who develop keratoconus start out nearsighted, which tends to become worse over time. the earliest symptom is a slight blurring of vision that cannot be corrected with glasses. over time, there may be eye halos, glare, or other night vision problems.the cause is unknown, but the tendency to develop keratoconus is probably present from birth. keratoconus is thought to involve a defect in collagen, the tissue that makes up most of the cornea. some researchers believe that allergy and eye rubbing may play a role. treatment for keratoconus depends on the severity of your condition and how quickly the condition is progressing. mild to moderate keratoconus can be treated with eyeglasses or contact lenses. in some people the cornea becomes scarred or wearing contact lenses becomes difficult. in these cases, surgery might be necessary. last updated: 3/23/2016

MalaCards based summary : Keratoconus, also known as noninflammatory corneal thining, is related to leber congenital amaurosis 9 and keratoconus 1. An important gene associated with Keratoconus is VSX1 (Visual System Homeobox 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Interleukin-4 and 13 signaling. The drugs Ranibizumab and Gabapentin have been mentioned in the context of this disorder. Affiliated tissues include Eye, eye and endothelial, and related phenotype is vision/eye.

Disease Ontology : 12 A corneal disease characterized by structural changes within the cornea causing it to thin and change, leading to a protruding conical shape.

Wikipedia : 71 Keratoconus (KC) is a disorder of the eye which results in progressive thinning of the cornea. This may... more...

Related Diseases for Keratoconus

Diseases in the Keratoconus family:

Keratoconus 4 Keratoconus 3
Keratoconus 5 Keratoconus 6
Keratoconus 7 Keratoconus 8
Keratoconus 2 Keratoconus 1

Diseases related to Keratoconus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
id Related Disease Score Top Affiliating Genes
1 leber congenital amaurosis 9 31.0 AIPL1 CRB1 GUCY2D RPE65
2 keratoconus 1 12.2
3 keratoconus 5 12.1
4 keratoconus 6 12.1
5 keratoconus 7 12.0
6 keratoconus 8 12.0
7 keratoconus posticus circumscriptus 11.9
8 mental retardation, keratoconus, febrile seizures, and sinoatrial block 11.8
9 keratoconus 3 11.8
10 acute hydrops keratoconus 11.8
11 stable condition keratoconus 11.8
12 keratoconus 2 11.8
13 keratoconus 4 11.8
14 pellucid marginal degeneration 11.0
15 edict syndrome 11.0
16 leber congenital amaurosis 11.0
17 retinitis pigmentosa 11.0
18 leber congenital amaurosis 6 10.8
19 brittle cornea syndrome 2 10.8
20 leber congenital amaurosis 2 10.8
21 leber congenital amaurosis 8 10.8
22 brittle cornea syndrome 1 10.8
23 leber congenital amaurosis 11 10.8
24 leber congenital amaurosis 4 10.8
25 leber congenital amaurosis 1 10.8
26 leber congenital amaurosis 7 10.8
27 leber congenital amaurosis 13 10.6
28 leber congenital amaurosis 14 10.6
29 leber congenital amaurosis 3 10.6
30 leber congenital amaurosis 15 10.6
31 retinitis pigmentosa 7 and digenic 10.6
32 leber congenital amaurosis 5 10.6
33 leber congenital amaurosis 12 10.6
34 leber congenital amaurosis 17 10.6
35 corneal fleck dystrophy 10.6
36 arterial tortuosity syndrome 10.6
37 leber congenital amaurosis 16 10.6
38 leber congenital amaurosis 10 10.6
39 craniofacial anomalies and anterior segment dysgenesis syndrome 10.3 VSX1 ZNF469
40 astigmatism 10.2
41 cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia 10.2 GUCY2D RPE65
42 ichthyosis, congenital, autosomal recessive 3 10.2 AIPL1 RPE65
43 bartholin's duct cyst 10.2 CRB1 GUCY2D
44 kleptomania 10.2 MMP1 MMP2
45 fountain syndrome 10.2 AIPL1 RPE65
46 anophthalmia-esophageal atresia-genital abnormalities syndrome 10.2 AIPL1 GUCY2D RPE65
47 noonan syndrome 4 10.2 MMP1 MMP2
48 rpl5-related diamond-blackfan anemia 10.2 AIPL1 GUCY2D RPE65
49 endotheliitis 10.2
50 corneal ectasia 10.2

Graphical network of the top 20 diseases related to Keratoconus:



Diseases related to Keratoconus

Symptoms & Phenotypes for Keratoconus

MGI Mouse Phenotypes related to Keratoconus:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.17 AIPL1 CRB1 GUCY2D KERA MMP2 RPE65

Drugs & Therapeutics for Keratoconus

Drugs for Keratoconus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 145)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4 347396-82-1 459903
2
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
3
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
4
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-88-5 493570
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
6 Angiogenesis Inhibitors Phase 4
7 Angiogenesis Modulating Agents Phase 4
8 Ophthalmic Solutions Phase 4,Phase 2,Phase 3,Phase 1
9 Tetrahydrozoline Phase 4,Phase 2,Phase 3
10 Anti-Inflammatory Agents Phase 4,Phase 2
11 Antirheumatic Agents Phase 4
12 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
13 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
14 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
15 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1
17 Photosensitizing Agents Phase 4,Phase 3,Phase 2,Phase 1
18 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1
19 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1
20 Vitamins Phase 4,Phase 3,Phase 2,Phase 1
21 Analgesics Phase 4
22 Analgesics, Non-Narcotic Phase 4
23 Anti-Anxiety Agents Phase 4
24 Anticonvulsants Phase 4
25 Anti-Inflammatory Agents, Non-Steroidal Phase 4
26 Antimanic Agents Phase 4
27 Antiparkinson Agents Phase 4
28 calcium channel blockers Phase 4
29 Calcium, Dietary Phase 4
30 Cyclooxygenase Inhibitors Phase 4
31 Excitatory Amino Acid Antagonists Phase 4
32 Excitatory Amino Acids Phase 4
33 Ketorolac Tromethamine Phase 4
34 Neurotransmitter Agents Phase 4
35 Psychotropic Drugs Phase 4
36 Tranquilizing Agents Phase 4
37 Vitamin B2 Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
38 Folate Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
39 Vitamin B9 Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
40
Lidocaine Approved, Vet_approved Phase 2, Phase 3 137-58-6 3676
41
Dipivefrin Approved Phase 3 52365-63-6 3105
42
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
43 tannic acid Approved, Nutraceutical Phase 3
44
Flavin Mononucleotide Experimental Phase 2, Phase 3 146-17-8 643976
45 Anesthetics Phase 3,Phase 2
46 Anti-Bacterial Agents Phase 3,Phase 1
47 Antibiotics, Antitubercular Phase 3,Phase 1
48 Anesthetics, Local Phase 2, Phase 3
49 Anti-Arrhythmia Agents Phase 2, Phase 3
50 Dextrans Phase 2, Phase 3, Phase 1

Interventional clinical trials:

(show top 50) (show all 153)
id Name Status NCT ID Phase
1 Evaluation of Changes in the Parameters of Optical Coherence Tomography After Intravitreal Injection of Lucentis Unknown status NCT01669447 Phase 4
2 Effect of CACICOL20 on Corneal Epithelial Healing After Cross-linking in Patients With Keratoconus Completed NCT02119039 Phase 4
3 Intrastromal Corneal Ring Segment Implantation in 219 Keratoconic Eyes at Different Stages Completed NCT01261013 Phase 4
4 Pain Management in Corneal Collagen Crosslinking for Keratoconus Completed NCT02867176 Phase 4
5 Relationship Between Central Corneal Thickness and Intraocular Pressure Measures Instruments. Completed NCT00347191 Phase 4
6 Corneal Thickness Changes During Corneal Collagen Cross-linking With Ultraviolet-A Irradiation and Riboflavin Completed NCT01485211 Phase 4
7 Intrastromal Corneal Ring for High Astigmatism on Postkeratoplasty Completed NCT01018797 Phase 4
8 CXL-04 A Study of Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas Recruiting NCT01956474 Phase 4
9 Safety and Effectiveness of Collagen Cross Linking in Progressive Mild and Moderate Keratoconus Unknown status NCT00815256 Phase 3
10 Treatment of Keratoconus Using Collagen Cross-Linking Unknown status NCT00841386 Phase 2, Phase 3
11 Comparison of Penetrating Keratoplasty and Deep Lamellar Keratoplasty With the Big Bubble Technique for Keratoconus Unknown status NCT00371202 Phase 3
12 Collagen Cross-Linking for Keratoconus/Ectasia With and Without Intacs Unknown status NCT01081561 Phase 2, Phase 3
13 Evaluating Collagen Cross-Linking (CCL) Treatment in Norway Unknown status NCT00435799 Phase 2, Phase 3
14 Corneal Cross-Linking Comparing Variables Unknown status NCT02095730 Phase 3
15 Riboflavin Mediated Corneal Crosslinking for Stabilizing Progression of Keratoconus Completed NCT00626717 Phase 2, Phase 3
16 Corneal Sensitivity Cross-linking Keratoconus Completed NCT01743443 Phase 2, Phase 3
17 Corneal Collagen Cross-linking for Progressive Keratoconus Completed NCT00647699 Phase 3
18 Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia Completed NCT00567671 Phase 2, Phase 3
19 Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus Completed NCT01643226 Phase 3
20 Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus Completed NCT01344187 Phase 3
21 Deep Anterior Lamellar Keratoplasty (DALK) Completed NCT00887900 Phase 3
22 Non-inferiority Trial of Iontophoretic Corneal Collagen Crosslinking (CXL) Compared to Standard Corneal Collagen Crosslinking in Progressive Keratoconus. Recruiting NCT01868620 Phase 3
23 Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical Trial Recruiting NCT01604135 Phase 3
24 Evaluating the Safety and Efficacy of the KXL System for Corneal Collagen Cross-Linking in Eyes Having Keratoconus Recruiting NCT02638376 Phase 3
25 Safety and Effectiveness of Corneal Crosslinking (CXL): Keratoconus and Post-Refractive Ectasia Recruiting NCT03080077 Phase 3
26 The Effects of Corneal Collagen Cross-linking Recruiting NCT01708538 Phase 3
27 Microwave Treatment and Corneal Collagen Crosslinking for Keratoconus Active, not recruiting NCT01672814 Phase 3
28 Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic Riboflavin Active, not recruiting NCT01152541 Phase 3
29 Safety and Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus Active, not recruiting NCT01972854 Phase 3
30 Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia Active, not recruiting NCT01464268 Phase 3
31 Corneal Collagen Crosslinking and Intacs for Keratoconus and Ectasia Active, not recruiting NCT01112072 Phase 3
32 Refractive Treatment of Early Keratoconus Not yet recruiting NCT02613780 Phase 3
33 Safety Study of the VEGA UV-A System to Treat Keratoconus Terminated NCT01190306 Phase 3
34 Safety and Effectiveness Study of the VEGA UV-A System for Cross-linking in Eyes With Keratoconus and Ectasia Terminated NCT01398852 Phase 3
35 A Multi-Center, Randomized, Controlled Evaluation of the Safety and Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery Terminated NCT01459679 Phase 3
36 Corneal Cross Linking and Topography Guided Excimer Laser Treatment Terminated NCT01682993 Phase 3
37 Corneal Crosslinking in Keratoconus and Corneal Ectasia Withdrawn NCT00679666 Phase 2, Phase 3
38 Myoring Versus Keraring Implantation for Keratoconus Unknown status NCT01869517 Phase 2
39 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking for Compassionate Treatment in Pediatric Patients With Progressive Keratoconus Unknown status NCT00925327 Phase 2
40 UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia Unknown status NCT01325298 Phase 2
41 Transepithelial Corneal Collagen Cross-linking (CXL) in Treatment of Keratoconus Completed NCT01181219 Phase 2
42 Comparison of Partial Removal and Total Removal of the Corneal Epithelium on Keratoconus Completed NCT01809977 Phase 2
43 Lamellar Transplant With Lyophilized Corneas Completed NCT00409955 Phase 2
44 Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot Study Recruiting NCT01843101 Phase 2
45 Immunosuppression During Penetrating Keratoplasty, Using a Subconjunctival Implant Releasing Dexamethasone : Tolerance and Safety Pilot Study Recruiting NCT02834260 Phase 2
46 COLLAGEN CROSS-LINKING WITH ULTRAVIOLET-A IN ASYMMETRIC CORNEAS Recruiting NCT03029104 Phase 2
47 Treatment of Keratoconus With Advanced Corneal Crosslinking Active, not recruiting NCT02425150 Phase 2
48 Treatment of Keratoconus With Advanced CXL-II Active, not recruiting NCT02514200 Phase 2
49 Adapted Fluence Settings for Corneal Collagen Cross-linking in Mild to Moderate Progressive Keratoconus Active, not recruiting NCT02507362 Phase 1, Phase 2
50 Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia Active, not recruiting NCT01143389 Phase 2

Search NIH Clinical Center for Keratoconus

Cochrane evidence based reviews: keratoconus

Genetic Tests for Keratoconus

Anatomical Context for Keratoconus

MalaCards organs/tissues related to Keratoconus:

39
Eye, Endothelial, Testes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Keratoconus:
id Tissue Anatomical CompartmentCell Relevance
1 Eye Corneal Stroma Keratocytes Affected by disease

Publications for Keratoconus

Articles related to Keratoconus:

(show top 50) (show all 838)
id Title Authors Year
1
KTCNlncDB-a first platform to investigate lncRNAs expressed in human keratoconus and non-keratoconus corneas. ( 28077570 )
2017
2
Keratoconus and Bowman Layer Transplantation. ( 28079692 )
2017
3
Keratoconus associated with Williams-Beuren syndrome: a new case report. ( 28503444 )
2017
4
New web-based algorithm to improve rigid gas permeable contact lens fitting in keratoconus. ( 28057440 )
2017
5
Efficacy of Intrastromal Corneal Ring Segments Combined With Flash Collagen Cross-Linking in Keratoconus. ( 28060059 )
2017
6
Corneo-scleral contact lens in a piggyback system for keratoconus: A case report. ( 28073689 )
2017
7
Conventional and Iontophoresis Corneal Cross-Linking for Keratoconus: Efficacy and Assessment by Optical Coherence Tomography and Confocal Microscopy. ( 28060061 )
2017
8
Ocular Surface Disease Parameters After Collagen Cross-Linking for Keratoconus. ( 28060060 )
2017
9
Corneal Imaging Abnormalities in Familial Keratoconus. ( 28068450 )
2017
10
Urea, Uric Acid, Prolactin and fT4 Concentrations in Aqueous Humor of Keratoconus Patients. ( 28085502 )
2017
11
Risk Factors for Keratoconus: Atopy and Eye Rubbing. ( 27755195 )
2017
12
Corneal Collagen Cross-Linking for Keratoconus in Pediatric Patients-Long-Term Results. ( 28060058 )
2017
13
Trends in Corneal Transplantation in Keratoconus. ( 28060057 )
2017
14
Accelerated transepithelial corneal cross-linking for progressive keratoconus: a prospective study of 12a88months. ( 28057642 )
2017
15
Removal and Repositioning of Intracorneal Ring Segments: Improving Corneal Topography and Clinical Outcomes in Keratoconus and Ectasia. ( 28060075 )
2017
16
Pilot Study of Corneal Sensitivity and Its Association in Keratoconus. ( 28060062 )
2017
17
Evaluation of Serum Superoxide Dismutase Activity, Malondialdehyde, and Zinc and Copper Levels in Patients With Keratoconus. ( 27617869 )
2016
18
Very low prevalence of keratoconus in a large series of vernal keratoconjunctivitis patients. ( 27640005 )
2016
19
Outcome of Keratoconus Management: Review of the Past 20 Years' Contemporary Treatment Modalities. ( 27171132 )
2016
20
Accelerated versus conventional corneal collagen cross-linking in patients with keratoconus: an intrapatient comparative study. ( 28035498 )
2016
21
Novel Technique of Transepithelial Corneal Cross-Linking Using Iontophoresis in Progressive Keratoconus. ( 27597895 )
2016
22
Corrigendum to "Expression of HGF and c-Met Proteins in Human Keratoconus Corneas". ( 27610241 )
2016
23
Predictive Ability of Galilei to Distinguish Subclinical Keratoconus and Keratoconus from Normal Corneas. ( 27195079 )
2016
24
One-year Outcomes of Pachymetry and Epithelium Thicknesses after Accelerated (45a88mW/cm(2)) Transepithelial Corneal Collagen Cross-linking for Keratoconus Patients. ( 27597655 )
2016
25
Effect of corneal cross-linking on contact lens tolerance in keratoconus. ( 27654998 )
2016
26
Visual Outcomes of Successful versus Failed Big-Bubble Deep Anterior Lamellar Keratoplasty for Keratoconus. ( 27195082 )
2016
27
Visual, Keratometric and Corneal Biomechanical Changes after Intacs SK Implantation for Moderate to Severe Keratoconus. ( 27195080 )
2016
28
Evaluation of the diagnostic ability of vector parameters characterizing the corneal astigmatism and regularity in clinical and subclinical keratoconus. ( 27931882 )
2016
29
Genomic strategies to understand causes of keratoconus. ( 28032277 )
2016
30
Keratoconus in Patients with Macular Stromal Dystrophy. ( 27455826 )
2016
31
The influence of rigid gas permeable lens wear on the concentrations of dinucleotides in tears and the effect on dry eye signs and symptoms in keratoconus. ( 27209480 )
2016
32
Wave Front-Guided Photorefractive Keratectomy Using a High-Resolution Aberrometer After Corneal Collagen Cross-Linking in Keratoconus. ( 27191671 )
2016
33
Effect of Cycloplegia on Keratometric and Biometric Parameters in Keratoconus. ( 28058115 )
2016
34
Development of a Keratoconus-Specific Questionnaire Using Rasch Analysis. ( 28027275 )
2016
35
Higher incidence of steroid-induced ocular hypertension in keratoconus. ( 26909354 )
2016
36
Ocular Surface Temperature During Scleral Lens Wearing in Patients With Keratoconus. ( 27203795 )
2016
37
Bilateral Atypical Granular Corneal Dystrophy Associated with Unilateral Keratoconus in a Male Child. ( 27555713 )
2016
38
Epithelial Thickness Profile Change After Combined Topography-Guided Transepithelial Photorefractive Keratectomy and Corneal Cross-linking in Treatment of Keratoconus. ( 27598733 )
2016
39
Screening for MIR184 Mutations in Iranian Patients with Keratoconus. ( 27195078 )
2016
40
A case of unilateral circumscribed posterior keratoconus evaluated by three different imaging tools: optical coherence tomography, videokeratography, and Scheimpflug corneal tomography. ( 27177621 )
2016
41
Post Filtering Surgery Globe Massage-induced Keratoconus in an Eye with Iridocorneal Endothelial Syndrome: A Case Report and Literature Brief Review. ( 27621792 )
2016
42
Association between Family History and Keratoconus Severity. ( 27158890 )
2016
43
Novel visual system homeobox 1 gene mutations in Turkish patients with keratoconus. ( 27819732 )
2016
44
Effect of a Matrix Therapy Agent on Corneal Epithelial Healing After Standard Collagen Cross-linking in Patients With Keratoconus: A Randomized Clinical Trial. ( 27584715 )
2016
45
Mini-scleral Contact Lens for Management of Poor Visual Outcomes after Intrastromal Corneal Ring Segments Implantation in Keratoconus. ( 27621780 )
2016
46
Evaluation of anterior segment parameters using Scheimpflug technology during the Valsalva maneuver in patients with keratoconus. ( 28076560 )
2016
47
Induction of matrix metalloproteinase-1 by tumor necrosis factor-I+ is mediated by interleukin-6 in cultured fibroblasts of keratoconus. ( 27207902 )
2016
48
Nationwide reduction in the number of corneal transplantations for keratoconus following the implementation of cross-linking. ( 27213687 )
2016
49
Spontaneous Descemet Membrane Detachment 20 Years After Penetrating Keratoplasty for Keratoconus. ( 27158806 )
2016
50
Change in Accommodation and Ocular Aberrations in Keratoconus Patients Fitted With Scleral Lenses. ( 27607148 )
2016

Variations for Keratoconus

Expression for Keratoconus

Search GEO for disease gene expression data for Keratoconus.

Pathways for Keratoconus

GO Terms for Keratoconus

Cellular components related to Keratoconus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.35 MMP1 MMP10 MMP2 TIMP1 TNC
2 proteinaceous extracellular matrix GO:0005578 9.1 KERA MMP1 MMP10 MMP2 TIMP1 TNC

Biological processes related to Keratoconus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.72 AIPL1 GUCY2D KERA RPE65 VSX1
2 cellular protein metabolic process GO:0044267 9.56 MMP1 MMP2 TIMP1 TNC
3 visual perception GO:0007601 9.35 AIPL1 GUCY2D KERA RPE65 VSX1
4 collagen catabolic process GO:0030574 9.33 MMP1 MMP10 MMP2
5 extracellular matrix disassembly GO:0022617 8.92 MMP1 MMP10 MMP2 TIMP1

Molecular functions related to Keratoconus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 metalloendopeptidase activity GO:0004222 8.8 MMP1 MMP10 MMP2

Sources for Keratoconus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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