MCID: KRT007
MIFTS: 48

Keratoconus

Categories: Rare diseases, Eye diseases, Genetic diseases

Aliases & Classifications for Keratoconus

MalaCards integrated aliases for Keratoconus:

Name: Keratoconus 38 12 50 25 52 42 14 69
Conical Cornea 12 25
Kc 50 25
Noninflammatory Corneal Thining 50
Bulging Cornea 25

Classifications:



External Ids:

Disease Ontology 12 DOID:10126
ICD10 33 H18.6 H18.60
ICD9CM 35 371.6 371.60
MeSH 42 D007640
NCIt 47 C26806
UMLS 69 C0022578

Summaries for Keratoconus

NIH Rare Diseases : 50 keratoconus is the degeneration of the structure of the cornea, which is the clear tissue covering the front of the eye. in this condition, the shape of the cornea slowly changes from the normal round shape to a cone shape. most people who develop keratoconus start out nearsighted, which tends to become worse over time. the earliest symptom is a slight blurring of vision that cannot be corrected with glasses. over time, there may be eye halos, glare, or other night vision problems.the cause is unknown, but the tendency to develop keratoconus is probably present from birth. keratoconus is thought to involve a defect in collagen, the tissue that makes up most of the cornea. some researchers believe that allergy and eye rubbing may play a role. treatment for keratoconus depends on the severity of your condition and how quickly the condition is progressing. mild to moderate keratoconus can be treated with eyeglasses or contact lenses. in some people the cornea becomes scarred or wearing contact lenses becomes difficult. in these cases, surgery might be necessary. last updated: 3/23/2016

MalaCards based summary : Keratoconus, also known as conical cornea, is related to leber congenital amaurosis 12 and leber congenital amaurosis 9. An important gene associated with Keratoconus is VSX1 (Visual System Homeobox 1), and among its related pathways/superpathways are Interleukin-4 and 13 signaling and Matrix Metalloproteinases. The drugs Ranibizumab and Gabapentin have been mentioned in the context of this disorder. Affiliated tissues include Eye, eye and endothelial, and related phenotype is vision/eye.

Genetics Home Reference : 25 Keratoconus is an eye condition that affects the shape of the cornea, which is the clear outer covering of the eye. In this condition, the cornea thins and bulges outward, eventually resembling a cone shape. These corneal abnormalities, which worsen over time, can lead to nearsightedness (myopia), blurred vision that cannot be improved with corrective lenses (irregular astigmatism), and vision loss.

Disease Ontology : 12 A corneal disease characterized by structural changes within the cornea causing it to thin and change, leading to a protruding conical shape.

Wikipedia : 72 Keratoconus (KC) is a disorder of the eye which results in progressive thinning of the cornea. This may... more...

Related Diseases for Keratoconus

Diseases in the Keratoconus family:

Keratoconus 4 Keratoconus 3
Keratoconus 5 Keratoconus 6
Keratoconus 7 Keratoconus 8
Keratoconus 2 Keratoconus 1

Diseases related to Keratoconus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
id Related Disease Score Top Affiliating Genes
1 leber congenital amaurosis 12 32.0 GUCY2D RPE65
2 leber congenital amaurosis 9 30.9 AIPL1 CRB1 CRX GUCY2D RPE65
3 leber congenital amaurosis 23.4 ACP2 AIPL1 CRB1 CRX ENO1 GUCY2D
4 keratoconus 1 12.1
5 keratoconus 6 12.0
6 keratoconus 5 12.0
7 keratoconus 7 12.0
8 keratoconus 8 12.0
9 keratoconus posticus circumscriptus 11.8
10 mental retardation, keratoconus, febrile seizures, and sinoatrial block 11.8
11 keratoconus 3 11.7
12 acute hydrops keratoconus 11.7
13 keratoconus 2 11.7
14 stable condition keratoconus 11.7
15 keratoconus 4 11.7
16 pellucid marginal degeneration 11.1
17 edict syndrome 11.0
18 retinitis pigmentosa 11.0
19 hypogonadotropic hypogonadism 21 with anosmia 10.8 VSX1 ZNF469
20 leber congenital amaurosis 11 10.8
21 leber congenital amaurosis 4 10.8
22 leber congenital amaurosis 1 10.8
23 leber congenital amaurosis 7 10.8
24 leber congenital amaurosis 6 10.8
25 brittle cornea syndrome 2 10.8
26 leber congenital amaurosis 2 10.8
27 leber congenital amaurosis 8 10.8
28 brittle cornea syndrome 1 10.8
29 pyuria 10.7 KERA VSX1
30 gapo syndrome 10.7
31 leber congenital amaurosis 17 10.7
32 leber congenital amaurosis 16 10.7
33 arterial tortuosity syndrome 10.7
34 leber congenital amaurosis 10 10.7
35 leber congenital amaurosis 13 10.7
36 leber congenital amaurosis 14 10.7
37 leber congenital amaurosis 3 10.7
38 leber congenital amaurosis 15 10.7
39 retinitis pigmentosa 7 and digenic 10.7
40 leber congenital amaurosis 5 10.7
41 ventricular extrasystoles with syncope, perodactyly, and robin sequence 10.6 AIPL1 RPE65
42 aloxe3-related autosomal recessive congenital ichthyosis 10.5 AIPL1 GUCY2D RPE65
43 kleptomania 10.5 MMP1 MMP2
44 ciliary dyskinesia, primary, 9, with or without situs inversus 10.4 CRB1 CRX GUCY2D
45 osteopoikilosis and dacryocystitis 10.4 CRB1 CRX RPE65
46 liver lymphoma 10.4 MMP1 MMP2
47 xanthogranulomatous cholecystitis 10.4 MMP1 MMP2
48 epileptic encephalopathy, early infantile, 1 10.4 CRB1 CRX RPE65
49 cecum adenoma 10.4 MMP2 TIMP1
50 limbic encephalitis 10.3 MMP1 MMP2

Graphical network of the top 20 diseases related to Keratoconus:



Diseases related to Keratoconus

Symptoms & Phenotypes for Keratoconus

MGI Mouse Phenotypes related to Keratoconus:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.23 AIPL1 CRB1 CRX GUCY2D KERA MMP2

Drugs & Therapeutics for Keratoconus

Drugs for Keratoconus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 143)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4 347396-82-1 459903
2
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
3
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
4
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-88-5 493570
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
6
Flavin Mononucleotide Experimental Phase 4,Phase 2,Phase 3 146-17-8 643976
7 Angiogenesis Inhibitors Phase 4
8 Angiogenesis Modulating Agents Phase 4
9 Ophthalmic Solutions Phase 4,Phase 2,Phase 3,Phase 1
10 Tetrahydrozoline Phase 4,Phase 2,Phase 3
11 Anti-Inflammatory Agents Phase 4,Phase 2
12 Antirheumatic Agents Phase 4
13 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
14 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
15 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
16 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
17 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1
18 Photosensitizing Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1
20 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1
21 Vitamins Phase 4,Phase 3,Phase 2,Phase 1
22 Analgesics Phase 4
23 Analgesics, Non-Narcotic Phase 4
24 Anti-Anxiety Agents Phase 4
25 Anticonvulsants Phase 4
26 Anti-Inflammatory Agents, Non-Steroidal Phase 4
27 Antimanic Agents Phase 4
28 Antiparkinson Agents Phase 4
29 calcium channel blockers Phase 4
30 Calcium, Dietary Phase 4
31 Cyclooxygenase Inhibitors Phase 4
32 Excitatory Amino Acid Antagonists Phase 4
33 Excitatory Amino Acids Phase 4
34 Ketorolac Tromethamine Phase 4
35 Neurotransmitter Agents Phase 4
36 Psychotropic Drugs Phase 4
37 Tranquilizing Agents Phase 4
38 Vitamin B2 Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
39 Folate Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
40 Vitamin B9 Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
41
Lidocaine Approved, Vet_approved Phase 2, Phase 3 137-58-6 3676
42
Dipivefrin Approved Phase 3 52365-63-6 3105
43
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
44 tannic acid Approved, Nutraceutical Phase 3
45 Anesthetics Phase 3,Phase 2
46 Anti-Bacterial Agents Phase 3,Phase 1
47 Antibiotics, Antitubercular Phase 3,Phase 1
48 Anesthetics, Local Phase 2, Phase 3
49 Anti-Arrhythmia Agents Phase 2, Phase 3
50 Dextrans Phase 2, Phase 3, Phase 1

Interventional clinical trials:

(show top 50) (show all 161)

id Name Status NCT ID Phase Drugs
1 Evaluation of Changes in the Parameters of Optical Coherence Tomography After Intravitreal Injection of Lucentis Unknown status NCT01669447 Phase 4
2 Effect of CACICOL20 on Corneal Epithelial Healing After Cross-linking in Patients With Keratoconus Completed NCT02119039 Phase 4
3 Intrastromal Corneal Ring Segment Implantation in 219 Keratoconic Eyes at Different Stages Completed NCT01261013 Phase 4
4 Pain Management in Corneal Collagen Crosslinking for Keratoconus Completed NCT02867176 Phase 4 Gabapentin;Ketorolac
5 Relationship Between Central Corneal Thickness and Intraocular Pressure Measures Instruments. Completed NCT00347191 Phase 4
6 Corneal Thickness Changes During Corneal Collagen Cross-linking With Ultraviolet-A Irradiation and Riboflavin Completed NCT01485211 Phase 4 cross-linking with hypo-osmolar riboflavin
7 Intrastromal Corneal Ring for High Astigmatism on Postkeratoplasty Completed NCT01018797 Phase 4
8 CXL-04 A Study of Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas Recruiting NCT01956474 Phase 4
9 Epi-On Corneal Crosslinking for Keratoconus Enrolling by invitation NCT03245853 Phase 4 Riboflavin 5'-Phosphate
10 Safety and Effectiveness of Collagen Cross Linking in Progressive Mild and Moderate Keratoconus Unknown status NCT00815256 Phase 3
11 Treatment of Keratoconus Using Collagen Cross-Linking Unknown status NCT00841386 Phase 2, Phase 3 Riboflavin-5-phosphate;Sham cross-linking
12 Comparison of Penetrating Keratoplasty and Deep Lamellar Keratoplasty With the Big Bubble Technique for Keratoconus Unknown status NCT00371202 Phase 3
13 Collagen Cross-Linking for Keratoconus/Ectasia With and Without Intacs Unknown status NCT01081561 Phase 2, Phase 3 Riboflavin
14 Evaluating Collagen Cross-Linking (CCL) Treatment in Norway Unknown status NCT00435799 Phase 2, Phase 3 Riboflavin/dextran eyedrops
15 Corneal Cross-Linking Comparing Variables Unknown status NCT02095730 Phase 3 Epithelium-On Riboflavin;Epithelium-Off Riboflavin
16 Riboflavin Mediated Corneal Crosslinking for Stabilizing Progression of Keratoconus Completed NCT00626717 Phase 2, Phase 3
17 Corneal Sensitivity Cross-linking Keratoconus Completed NCT01743443 Phase 2, Phase 3
18 Microwave Treatment and Corneal Collagen Crosslinking for Keratoconus Completed NCT01672814 Phase 3 riboflavin ophthalmic solution
19 Corneal Collagen Cross-linking for Progressive Keratoconus Completed NCT00647699 Phase 3 riboflavin ophthalmic solution
20 Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia Completed NCT00567671 Phase 2, Phase 3
21 Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus Completed NCT01643226 Phase 3 riboflavin solution;placebo solution
22 Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus Completed NCT01344187 Phase 3 riboflavin solution;placebo solution
23 Deep Anterior Lamellar Keratoplasty (DALK) Completed NCT00887900 Phase 3
24 Non-inferiority Trial of Iontophoretic Corneal Collagen Crosslinking (CXL) Compared to Standard Corneal Collagen Crosslinking in Progressive Keratoconus. Recruiting NCT01868620 Phase 3
25 Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical Trial Recruiting NCT01604135 Phase 3
26 Evaluating the Safety and Efficacy of the KXL System for Corneal Collagen Cross-Linking in Eyes Having Keratoconus Recruiting NCT02638376 Phase 3
27 Safety and Effectiveness of Corneal Crosslinking (CXL): Keratoconus and Post-Refractive Ectasia Recruiting NCT03080077 Phase 3 Ricrolin+;Epi-Off
28 The Effects of Corneal Collagen Cross-linking Recruiting NCT01708538 Phase 3 CXL
29 Accelerated Corneal Cross-linking With Different Riboflavin Solutions Recruiting NCT03187912 Phase 3 Riboflavin
30 Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic Riboflavin Active, not recruiting NCT01152541 Phase 3 Riboflavin/Dextran;Hypotonic Riboflavin
31 Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia Active, not recruiting NCT01464268 Phase 3 Riboflavin;Riboflavin
32 Corneal Collagen Crosslinking and Intacs for Keratoconus and Ectasia Active, not recruiting NCT01112072 Phase 3 Riboflavin
33 Refractive Treatment of Early Keratoconus Not yet recruiting NCT02613780 Phase 3
34 Safety Study of the VEGA UV-A System to Treat Keratoconus Terminated NCT01190306 Phase 3 Riboflavin
35 Safety and Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus Terminated NCT01972854 Phase 3 riboflavin solution;placebo solution
36 Safety and Effectiveness Study of the VEGA UV-A System for Cross-linking in Eyes With Keratoconus and Ectasia Terminated NCT01398852 Phase 3 Riboflavin
37 A Multi-Center, Randomized, Controlled Evaluation of the Safety and Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery Terminated NCT01459679 Phase 3 riboflavin ophthalmic solution
38 Corneal Cross Linking and Topography Guided Excimer Laser Treatment Terminated NCT01682993 Phase 3
39 Corneal Crosslinking in Keratoconus and Corneal Ectasia Withdrawn NCT00679666 Phase 2, Phase 3 Riboflavin;Placebo
40 Adapted Fluence Settings for Corneal Collagen Cross-linking in Mild to Moderate Progressive Keratoconus Unknown status NCT02507362 Phase 1, Phase 2 riboflavin 0.1% combined with dextran 20 %
41 Myoring Versus Keraring Implantation for Keratoconus Unknown status NCT01869517 Phase 2
42 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking for Compassionate Treatment in Pediatric Patients With Progressive Keratoconus Unknown status NCT00925327 Phase 2
43 UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia Unknown status NCT01325298 Phase 2 Riboflavin;Riboflavin
44 Transepithelial Corneal Collagen Cross-linking (CXL) in Treatment of Keratoconus Completed NCT01181219 Phase 2
45 Comparison of Partial Removal and Total Removal of the Corneal Epithelium on Keratoconus Completed NCT01809977 Phase 2
46 Lamellar Transplant With Lyophilized Corneas Completed NCT00409955 Phase 2
47 Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot Study Recruiting NCT01843101 Phase 2
48 Immunosuppression During Penetrating Keratoplasty, Using a Subconjunctival Implant Releasing Dexamethasone : Tolerance and Safety Pilot Study Recruiting NCT02834260 Phase 2 Dexamethasone implant OZURDEX
49 COLLAGEN CROSS-LINKING WITH ULTRAVIOLET-A IN ASYMMETRIC CORNEAS Recruiting NCT03029104 Phase 2 CXLO Corneal Strengthening Solution and UVA Illumination
50 Treatment of Keratoconus With Advanced Corneal Crosslinking Active, not recruiting NCT02425150 Phase 2

Search NIH Clinical Center for Keratoconus

Cochrane evidence based reviews: keratoconus

Genetic Tests for Keratoconus

Anatomical Context for Keratoconus

MalaCards organs/tissues related to Keratoconus:

39
Eye, Endothelial, Testes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Keratoconus:
id Tissue Anatomical CompartmentCell Relevance
1 Eye Corneal Stroma Keratocytes Affected by disease

Publications for Keratoconus

Articles related to Keratoconus:

(show top 50) (show all 865)
id Title Authors Year
1
Cataract Surgery in Patients with Keratoconus: Pearls and Pitfalls. ( 28932335 )
2017
2
Corneal Collagen Cross-Linking for Keratoconus in Pediatric Patients-Long-Term Results. ( 28060058 )
2017
3
Predictive Factors of the Standard Cross-linking Outcomes in Adult Keratoconus: One-Year Follow-Up. ( 28951783 )
2017
4
Crab claw pattern on corneal topography: pellucid marginal degeneration or inferior keratoconus? ( 28937143 )
2017
5
A unique case of keratoconus with Cogan-Reese syndrome and secondary glaucoma. ( 28300746 )
2017
6
Conventional Corneal Collagen Cross-Linking Versus Transepithelial Diluted Alcohol and Iontophoresis-Assisted Corneal Cross-Linking in Progressive Keratoconus. ( 28922329 )
2017
7
Removal and Repositioning of Intracorneal Ring Segments: Improving Corneal Topography and Clinical Outcomes in Keratoconus and Ectasia. ( 28060075 )
2017
8
Accelerated transepithelial corneal cross-linking for progressive keratoconus: a prospective study of 12a88months. ( 28057642 )
2017
9
Long-term outcomes of corneal cross-linking for keratoconus in pediatric patients. ( 28935449 )
2017
10
Multifocal Choroiditis with Retinal Vasculitis, Optic Neuropathy, and Keratoconus in a Young Saudi Male. ( 28936058 )
2017
11
Ocular Surface Disease Parameters After Collagen Cross-Linking for Keratoconus. ( 28060060 )
2017
12
Trends in Corneal Transplantation in Keratoconus. ( 28060057 )
2017
13
New web-based algorithm to improve rigid gas permeable contact lens fitting in keratoconus. ( 28057440 )
2017
14
Penetrating Keratoplasty for Keratoconus - Excimer Versus Femtosecond Laser Trephination. ( 28932339 )
2017
15
Corneal Imaging Abnormalities in Familial Keratoconus. ( 28068450 )
2017
16
Corneo-scleral contact lens in a piggyback system for keratoconus: A case report. ( 28073689 )
2017
17
Genetics in Keratoconus - What is New? ( 28932336 )
2017
18
Pilot Study of Corneal Sensitivity and Its Association in Keratoconus. ( 28060062 )
2017
19
Collagen Cross- Linking for Paediatric Keratoconus. ( 28932337 )
2017
20
Analysis of the VSX1 gene in sporadic keratoconus patients from China. ( 28950846 )
2017
21
Contact Lenses for Keratoconus- Current Practice. ( 28932340 )
2017
22
Systematic review and Meta-analysis comparing modified cross-linking and standard cross-linking for progressive keratoconus. ( 28944203 )
2017
23
Risk Factors for Keratoconus: Atopy and Eye Rubbing. ( 27755195 )
2017
24
Mutation analysis of TGFBI and KRT12 in a case of concomitant keratoconus and granular corneal dystrophy. ( 28567551 )
2017
25
Keratoconus associated with Williams-Beuren syndrome: a new case report. ( 28503444 )
2017
26
Efficacy of Intrastromal Corneal Ring Segments Combined With Flash Collagen Cross-Linking in Keratoconus. ( 28060059 )
2017
27
Keratoconus and Bowman Layer Transplantation. ( 28079692 )
2017
28
Conventional and Iontophoresis Corneal Cross-Linking for Keratoconus: Efficacy and Assessment by Optical Coherence Tomography and Confocal Microscopy. ( 28060061 )
2017
29
Pathophysiology of Keratoconus: What Do We Know Today. ( 28932341 )
2017
30
Efficacy of different accelerated cornealA crosslinking protocols forA progressive keratoconus. ( 28917412 )
2017
31
Accelerated Epi-on Versus Standard Epi-off Corneal Collagen Cross-Linking for Progressive Keratoconus in Pediatric Patients. ( 28938381 )
2017
32
Urea, Uric Acid, Prolactin and fT4 Concentrations in Aqueous Humor of Keratoconus Patients. ( 28085502 )
2017
33
Lamina Cribrosa Thickness in Patients With Keratoconus. ( 28922330 )
2017
34
Clinical Study of Mitomycin C in Reducing Haze Formation After Ultraviolet A/Riboflavin Crosslinking for Keratoconus. ( 28945648 )
2017
35
Long-Term Follow-Up of Intrastromal Corneal Ring Segments in Paracentral Keratoconus with Coincident Corneal Keratometric, Comatic, and Refractive Axes: Stability of the Procedure. ( 28948045 )
2017
36
Accelerated 15A mW pulsed-light crosslinking to treat progressive keratoconus: Two-year clinical results. ( 28917411 )
2017
37
KTCNlncDB-a first platform to investigate lncRNAs expressed in human keratoconus and non-keratoconus corneas. ( 28077570 )
2017
38
Topographic outcomes after corneal collagen crosslinking in progressive keratoconus: 1-year follow-up. ( 28591281 )
2017
39
Editorial: Keratoconus - What We Do Not Know. ( 28932333 )
2017
40
Novel visual system homeobox 1 gene mutations in Turkish patients with keratoconus. ( 27819732 )
2016
41
Ocular Surface Temperature During Scleral Lens Wearing in Patients With Keratoconus. ( 27203795 )
2016
42
Evidence against ZNF469 being causative for keratoconus in Polish patients. ( 26806788 )
2016
43
Change in Accommodation and Ocular Aberrations in Keratoconus Patients Fitted With Scleral Lenses. ( 27607148 )
2016
44
Visual Outcomes of Successful versus Failed Big-Bubble Deep Anterior Lamellar Keratoplasty for Keratoconus. ( 27195082 )
2016
45
Association between Family History and Keratoconus Severity. ( 27158890 )
2016
46
Genomic strategies to understand causes of keratoconus. ( 28032277 )
2016
47
Femtosecond laser-assisted keratoplasty combined with cataract extraction in a patient with keratoconus and oculocutaneous albinism. ( 27146942 )
2016
48
Predictive Ability of Galilei to Distinguish Subclinical Keratoconus and Keratoconus from Normal Corneas. ( 27195079 )
2016
49
Mutational Analysis of Pre-miR-184 and hsa-mir-568 in Greek Patients With Sporadic Keratoconus. ( 26845316 )
2016
50
A case of unilateral circumscribed posterior keratoconus evaluated by three different imaging tools: optical coherence tomography, videokeratography, and Scheimpflug corneal tomography. ( 27177621 )
2016

Variations for Keratoconus

Expression for Keratoconus

Search GEO for disease gene expression data for Keratoconus.

Pathways for Keratoconus

GO Terms for Keratoconus

Cellular components related to Keratoconus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.26 MMP1 MMP10 MMP2 TIMP1
2 proteinaceous extracellular matrix GO:0005578 9.02 KERA MMP1 MMP10 MMP2 TIMP1

Biological processes related to Keratoconus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.63 AIPL1 CRX GUCY2D KERA RPE65 VSX1
2 collagen catabolic process GO:0030574 9.43 MMP1 MMP10 MMP2
3 extracellular matrix disassembly GO:0022617 9.26 MMP1 MMP10 MMP2 TIMP1
4 visual perception GO:0007601 9.1 AIPL1 CRX GUCY2D KERA RPE65 VSX1

Molecular functions related to Keratoconus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 metalloendopeptidase activity GO:0004222 8.8 MMP1 MMP10 MMP2

Sources for Keratoconus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....