Keratoderma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

MCID: KRT012 MIFTS: 31	Keratoderma malady
61 genes, 1 tissue, 247 related diseases, clinical trials, genetic tests.

Summaries for Keratoderma

Sources:
⁶³Wikipedia, ³²MalaCards
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Wikipedia:⁶³ Keratoderma is a hornlike skin condition. more...

MalaCards: Keratoderma is related to palmoplantar keratoderma, epidermolytic and palmoplantar keratosis. An important gene associated with Keratoderma is KRT16 (keratin 16), and among its related pathways are Apoptotic cleavage of cell adhesion proteins and Cytoskeleton remodeling Keratin filaments. The compounds collodion and epsilon-(gamma-glutamyl)lysine have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotype integument.

Aliases & Classifications for Keratoderma

Sources:
²⁰GeneTests, ⁴⁴Novoseek
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Aliases & Descriptions:

keratoderma ²⁰ ⁴⁴

Related Diseases for Keratoderma

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
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Diseases related to Keratoderma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 247)

id	Related Disease	Score	Top Affiliating Genes
1	palmoplantar keratoderma, epidermolytic	30.7	KRT16, KRT1, KRT9, KRT17, EVPL
2	palmoplantar keratosis	30.6	DSG1, SLURP1, KRT9, AAGAB
3	nonepidermolytic palmoplantar keratoderma	30.5	CYGB, KRTAP11-1, EVPL
4	diffuse palmoplantar keratoderma, bothnian type	30.5	KRT16, KRT9, KRT17
5	vohwinkel syndrome	30.5	LOR, GJB2
6	keratosis	30.3	DSP, GJB2, KRT16, KRT1, KRT10, LOR
7	pachyonychia congenita	30.3	KRT16, KRT17
8	epidermolytic hyperkeratosis	30.2	KRT1, KRT10
9	vohwinkel syndrome with ichthyosis	30.1	LOR
10	congenital ichthyosiform erythroderma	30.0	KRT10, TGM1
11	psoriasis	30.0	LOR, KRT16, KRT1, KRT10, KRT17, TGM1
12	skin disease	30.0	TGM1, LOR, DSP, DSG1, GJB3, GJB2
13	epidermolysis bullosa	29.9	DSP
14	sensorineural hearing loss	29.9	GJB3, GJB2
15	epidermolysis bullosa simplex	29.9	KRT16, KRT1, KRT10, KRT9, KRT17
16	clouston syndrome	29.9	GJB3, GJB2
17	squamous cell carcinoma	29.9	DSP, DSG1, GJB2, KRT16, KRT1, KRT10
18	dermatitis	29.6	LOR, DSG1, KRT16
19	lichen planus	29.6	KRT10, KRT1, KRT16
20	keratoderma palmoplantar deafness	10.5
21	cardiomyopathy dilated with woolly hair and keratoderma	10.4
22	unna-thost palmoplantar keratoderma	10.3
23	cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome	10.3
24	keratoderma palmoplantar spastic paralysis	10.3
25	focal palmoplantar keratoderma	10.3
26	curly hair-acral keratoderma-caries syndrome	10.2
27	erythrokeratodermia variabilis et progressiva	10.2
28	keratoderma, palmoplantar, punctate type ia	10.2
29	keratosis palmoplantaris striata i, ad	10.2
30	melanoma	10.2
31	tylosis with esophageal cancer	10.2
32	naxos disease	10.2
33	olmsted syndrome	10.2
34	palmoplantar keratoderma, nagashima type	10.2
35	autosomal dominant palmoplantar keratoderma and congenital alopecia	10.2
36	autosomal recessive palmoplantar keratoderma and congenital alopecia	10.2
37	alopecia	10.1
38	porokeratosis plantaris palmaris et disseminata	10.1
39	meleda disease	10.1
40	leukoencephalopathy palmoplantar keratoderma	10.1
41	keratosis linearis with ichthyosis congenita and sclerosing keratoderma	10.1
42	hypotrichosis-osteolysis-periodontitis-palmoplantar keratoderma syndrome	10.1
43	palmoplantar keratoderma-sclerodactyly syndrome	10.1
44	acquired hyperkeratosis	10.1
45	pityriasis rubra pilaris	10.1
46	erythropoietic protoporphyria	10.1
47	dilated cardiomyopathy	10.1
48	palmoplantar keratoderma of sybert	10.1
49	focal palmoplantar and gingival keratoderma	10.1
50	hereditary palmoplantar keratoderma, gamborg-nielsen type	10.1

Graphical network of the top 20 diseases related to Keratoderma:

Clinical Features for Keratoderma

Drugs & Therapeutics for Keratoderma

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Keratoderma

Drug clinical trials:

Search ClinicalTrials for Keratoderma

Search NIH Clinical Center for Keratoderma

Search CenterWatch for Keratoderma

Genetic Tests for Keratoderma

Sources:
²⁰GeneTests
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Genetic tests related to Keratoderma:

id	Genetic test	Affiliating Genes
1	Keratoderma²⁰

Anatomical Context for Keratoderma

Sources:
³²MalaCards
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MalaCards organs/tissues related to Keratoderma:

³²

Skin

Animal Models for Keratoderma or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Keratoderma:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument phenotype	MP:0010771	9.8	TGM1, DSP, GJB3, GJB2, KRT16, KRT1

Publications for Keratoderma

Genes related to Keratoderma

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
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Genes related to Keratoderma:

(show top 50) (show all 61)

id	Symbol	Description	Score	Implication
1	KRT16	keratin 16	20.22	GeneCards inferred : Publications, Disorders, Gene name, Summaries (show sections)
2	KRT9	keratin 9	19.88	GeneCards inferred : Publications, Disorders, Gene name, Summaries (show sections)
3	DSP	desmoplakin	19.54	GeneCards inferred : Publications, Disorders, Summaries (show sections)
4	AAGAB	alpha- and gamma-adaptin binding protein	19.20	GeneCards inferred : Publications, Disorders, Summaries (show sections)
5	KRT1	keratin 1	18.87	GeneCards inferred : Publications, Disorders (show sections)
6	GJB2	gap junction protein, beta 2, 26kDa	18.53	GeneCards inferred : Publications, Disorders (show sections)
7	DSG1	desmoglein 1	18.20	GeneCards inferred : Publications, Disorders (show sections)
8	KRT17	keratin 17	17.87	GeneCards inferred : Publications, Disorders (show sections)
9	LOR	loricrin	17.54	GeneCards inferred : Publications, Disorders (show sections)
10	SNAP29	synaptosomal-associated protein, 29kDa	17.21	GeneCards inferred : Publications, Disorders (show sections)
11	EVPL	envoplakin	16.88	GeneCards inferred : Disorders (show sections)
12	SLURP1	secreted LY6/PLAUR domain containing 1	16.55	GeneCards inferred : Publications, Disorders (show sections)
13	GJB3	gap junction protein, beta 3, 31kDa	16.22	GeneCards inferred : Publications, Disorders (show sections)
14	KRT6C	keratin 6C	15.90	GeneCards inferred : Publications, Disorders (show sections)
15	KRT10	keratin 10	15.57	GeneCards inferred : Publications, Disorders (show sections)
16	TGM1	transglutaminase 1	15.24	GeneCards inferred : Publications, Disorders (show sections)
17	PPKP1B	Keratoderma, palmoplantar, punctate type IB	14.93	GeneCards inferred : Disorders, Gene name (show sections)
18	PPKB	palmoplantar keratoderma, Bothnia type	14.61	GeneCards inferred : Disorders, Gene name (show sections)
19	KRTAP11-1	keratin associated protein 11-1	14.26	GeneCards inferred : Disorders (show sections)
20	CYGB	cytoglobin	13.93	GeneCards inferred : Disorders (show sections)
21	JUP	junction plakoglobin	13.60	GeneCards inferred : Publications, Disorders (show sections)
22	CTSC	cathepsin C	13.27	GeneCards inferred : Publications, Disorders (show sections)
23	KRT14	keratin 14	12.95	GeneCards inferred : Publications, Disorders (show sections)
24	POMP	proteasome maturation protein	12.62	GeneCards inferred : Disorders (show sections)
25	KRT5	keratin 5	12.29	GeneCards inferred : Publications, Disorders (show sections)
26	GJA1	gap junction protein, alpha 1, 43kDa	11.96	GeneCards inferred : Publications, Disorders (show sections)
27	TRPV3	transient receptor potential cation channel, subfamily V, member 3	11.63	GeneCards inferred : Disorders (show sections)
28	SEC14L1	SEC14-like 1 (S. cerevisiae)	11.31	GeneCards inferred : Disorders (show sections)
29	HELZ	helicase with zinc finger	10.98	GeneCards inferred : Disorders (show sections)
30	DNAH17	dynein, axonemal, heavy chain 17	10.65	GeneCards inferred : Disorders (show sections)
31	LOC619540	keratosis palmoplantaris papulosa	10.31	GeneCards inferred : Publications, Disorders (show sections)
32	NIPAL4	NIPA-like domain containing 4	9.99	GeneCards inferred : Publications, Disorders (show sections)
33	LELP1	late cornified envelope-like proline-rich 1	9.66	GeneCards inferred : Publications, Disorders (show sections)
34	TCHH	trichohyalin	9.33	GeneCards inferred : Publications, Disorders (show sections)
35	RTEL1	regulator of telomere elongation helicase 1	9.00	GeneCards inferred : Disorders (show sections)
36	KRT6A	keratin 6A	8.67	GeneCards inferred : Publications, Disorders (show sections)
37	GJB4	gap junction protein, beta 4, 30.3kDa	8.35	GeneCards inferred : Publications, Disorders (show sections)
38	KRT6B	keratin 6B	8.02	GeneCards inferred : Publications, Disorders (show sections)
39	GALR2	galanin receptor 2	7.69	GeneCards inferred : Disorders (show sections)
40	FECH	ferrochelatase	7.36	GeneCards inferred : Publications, Disorders (show sections)
41	RARG	retinoic acid receptor, gamma	7.04	GeneCards inferred : Publications, Disorders (show sections)
42	DSC2	desmocollin 2	6.71	GeneCards inferred : Publications, Disorders (show sections)
43	GJB6	gap junction protein, beta 6, 30kDa	6.38	GeneCards inferred : Publications, Disorders (show sections)
44	ALOX12B	arachidonate 12-lipoxygenase, 12R type	6.05	GeneCards inferred : Disorders (show sections)
45	WNT10A	wingless-type MMTV integration site family, member 10A	5.72	GeneCards inferred : Disorders (show sections)
46	ALOXE3	arachidonate lipoxygenase 3	5.40	GeneCards inferred : Disorders (show sections)
47	RSPO1	R-spondin 1	5.07	GeneCards inferred : Disorders (show sections)
48	DMC1	DNA meiotic recombinase 1	4.74	GeneCards inferred : Disorders (show sections)
49	CARD14	caspase recruitment domain family, member 14	4.41	GeneCards inferred : Disorders (show sections)
50	RHBDF2	rhomboid 5 homolog 2 (Drosophila)	4.08	GeneCards inferred : Disorders (show sections)

Products for genes related to Keratoderma disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	41	41	45
2	LSBio	-	-	50

Genetic Variations for Keratoderma

Expression for genes affiliated with Keratoderma

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratoderma

Search GEO for disease gene expression data for Keratoderma.

Pathways for genes affiliated with Keratoderma

Sources:
⁵³Reactome, ¹²EMD Millipore
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Pathways related to Keratoderma according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Apoptotic cleavage of cell adhesion proteins⁵³	10.4	DSG1, DSP
2	Cytoskeleton remodeling Keratin filaments¹²	10.1	EVPL, KRT17, KRT1, KRT16, KRT6C, DSP

Compounds for genes affiliated with Keratoderma

Sources:
⁴⁴Novoseek, ¹¹DrugBank, ⁵⁹Tocris Bioscience, ²⁸IUPHAR, ²⁴HMDB
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Compounds related to Keratoderma according to GeneCards/GeneDecks:

(show all 23)

id	Compound	Score	Top Affiliating Genes
1	collodion⁴⁴	10.6	TGM1, LOR
2	epsilon-(gamma-glutamyl)lysine⁴⁴	10.6	TGM1, LOR
3	isotretinoin⁴⁴ ¹¹	11.6	KRT16, KRT1, KRT10
4	calcipotriol⁴⁴ ⁵⁹ ²⁸ ¹¹	13.6	KRT16, KRT10, TGM1
5	dithranol⁴⁴	10.6	KRT10, KRT16
6	sodium dodecylsulfate⁴⁴	10.5	TGM1, KRT17, KRT1, KRT16
7	hematoxylin⁴⁴	10.5	KRT10, KRT1, LOR
8	tazarotene⁴⁴ ¹¹	11.5	KRT10, KRT1
9	asparagine⁴⁴	10.5	GJB2, KRT1, KRT17
10	paraffin⁴⁴	10.5	GJB2, KRT16, KRT1, KRT10, KRT17
11	histidine⁴⁴	10.4	LOR, CYGB, KRT10, KRT9
12	retinoid⁴⁴	10.4	GJB2, KRT16, KRT1, KRT10, KRT17, TGM1
13	proline⁴⁴	10.4	LOR, GJB3, GJB2, KRT16, KRT1, KRT10
14	gap 27⁵⁹	10.4	GJB3, GJB2
15	1,25 dihydroxy vitamin d3⁴⁴	10.4	KRT16, KRT10, TGM1
16	progesterone⁴⁴ ⁵⁹ ²⁸ ¹¹ ²⁴	14.4	DSP, GJB2, KRT1, KRT10, TGM1
17	steroid⁴⁴	10.4	LOR, DSP, SLURP1, KRT16, KRT1, KRT10
18	carbenoxolone disodium⁵⁹	10.3	GJB3, GJB2
19	octanol²⁸ ²⁴	11.3	GJB2, GJB3
20	retinoic acid⁴⁴ ²⁴	11.3	TGM1, LOR, DSP, DSG1, GJB2, KRT16
21	scrambled 10panx⁵⁹	10.2	GJB3, GJB2
22	serine⁴⁴	10.2	KRT17, KRT10, KRT1, KRT16, DSG1, DSP
23	10panx⁵⁹	10.0	GJB3, GJB2

GO Terms for genes affiliated with Keratoderma

Sources:
¹⁶Gene Ontology
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Cellular components related to Keratoderma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	connexon complex	GO:005922	10.3	GJB2, GJB3
2	cornified envelope	GO:001533	10.2	LOR, DSP, EVPL, TGM1
3	intermediate filament	GO:005882	10.2	KRT17, KRT9, KRT10, KRT16, KRT6C, DSP
4	keratin filament	GO:045095	10.1	KRT6C, KRT1, KRT10, KRTAP11-1
5	desmosome	GO:030057	10.0	EVPL, DSG1, DSP

Biological processes related to Keratoderma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament organization	GO:045109	10.3	KRT17, KRT9, DSP
2	peptide cross-linking	GO:018149	10.2	LOR, DSP, EVPL, TGM1
3	keratinocyte differentiation	GO:030216	10.2	TGM1, EVPL, KRT10, DSP, LOR
4	epidermis development	GO:008544	10.1	DSP, KRT16, KRT9, KRT17, EVPL
5	keratinization	GO:031424	9.9	TGM1, EVPL, KRT17, LOR

Molecular functions related to Keratoderma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	gap junction channel activity	GO:005243	10.3	GJB2, GJB3
2	structural constituent of cytoskeleton	GO:005200	10.1	LOR, DSP, KRT16, KRT9, KRT17
3	structural molecule activity	GO:005198	10.1	EVPL, KRTAP11-1, KRT1, KRT6C, DSP, LOR
4	protein binding, bridging	GO:030674	10.0	EVPL, DSP, LOR