MCID: KRT012
MIFTS: 31

Keratoderma malady

Summaries for Keratoderma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Keratoderma is a hornlike skin condition. more...

MalaCards: Keratoderma is related to palmoplantar keratoderma, epidermolytic and palmoplantar keratosis. An important gene associated with Keratoderma is KRT16 (keratin 16), and among its related pathways are Apoptotic cleavage of cell adhesion proteins and Cytoskeleton remodeling Keratin filaments. The compounds collodion and epsilon-(gamma-glutamyl)lysine have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotype integument.

Aliases & Classifications for Keratoderma

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20GeneTests, 44Novoseek
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Aliases & Descriptions:

keratoderma 20 44


Related Diseases for Keratoderma

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17GeneCards, 18GeneDecks
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Diseases related to Keratoderma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 247)
idRelated DiseaseScoreTop Affiliating Genes
1palmoplantar keratoderma, epidermolytic30.7KRT16, KRT1, KRT9, KRT17, EVPL
2palmoplantar keratosis30.6DSG1, SLURP1, KRT9, AAGAB
3nonepidermolytic palmoplantar keratoderma30.5CYGB, KRTAP11-1, EVPL
4diffuse palmoplantar keratoderma, bothnian type30.5KRT16, KRT9, KRT17
5vohwinkel syndrome30.5LOR, GJB2
6keratosis30.3DSP, GJB2, KRT16, KRT1, KRT10, LOR
7pachyonychia congenita30.3KRT16, KRT17
8epidermolytic hyperkeratosis30.2KRT1, KRT10
9vohwinkel syndrome with ichthyosis30.1LOR
10congenital ichthyosiform erythroderma30.0KRT10, TGM1
11psoriasis30.0LOR, KRT16, KRT1, KRT10, KRT17, TGM1
12skin disease30.0TGM1, LOR, DSP, DSG1, GJB3, GJB2
13epidermolysis bullosa29.9DSP
14sensorineural hearing loss29.9GJB3, GJB2
15epidermolysis bullosa simplex29.9KRT16, KRT1, KRT10, KRT9, KRT17
16clouston syndrome29.9GJB3, GJB2
17squamous cell carcinoma29.9DSP, DSG1, GJB2, KRT16, KRT1, KRT10
18dermatitis29.6LOR, DSG1, KRT16
19lichen planus29.6KRT10, KRT1, KRT16
20keratoderma palmoplantar deafness10.5
21cardiomyopathy dilated with woolly hair and keratoderma10.4
22unna-thost palmoplantar keratoderma10.3
23cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome10.3
24keratoderma palmoplantar spastic paralysis10.3
25focal palmoplantar keratoderma10.3
26curly hair-acral keratoderma-caries syndrome10.2
27erythrokeratodermia variabilis et progressiva10.2
28keratoderma, palmoplantar, punctate type ia10.2
29keratosis palmoplantaris striata i, ad10.2
30melanoma10.2
31tylosis with esophageal cancer10.2
32naxos disease10.2
33olmsted syndrome10.2
34palmoplantar keratoderma, nagashima type10.2
35autosomal dominant palmoplantar keratoderma and congenital alopecia10.2
36autosomal recessive palmoplantar keratoderma and congenital alopecia10.2
37alopecia10.1
38porokeratosis plantaris palmaris et disseminata10.1
39meleda disease10.1
40leukoencephalopathy palmoplantar keratoderma10.1
41keratosis linearis with ichthyosis congenita and sclerosing keratoderma10.1
42hypotrichosis-osteolysis-periodontitis-palmoplantar keratoderma syndrome10.1
43palmoplantar keratoderma-sclerodactyly syndrome10.1
44acquired hyperkeratosis10.1
45pityriasis rubra pilaris10.1
46erythropoietic protoporphyria10.1
47dilated cardiomyopathy10.1
48palmoplantar keratoderma of sybert10.1
49focal palmoplantar and gingival keratoderma10.1
50hereditary palmoplantar keratoderma, gamborg-nielsen type10.1

Graphical network of the top 20 diseases related to Keratoderma:



Diseases related to keratoderma

Clinical Features for Keratoderma

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Drugs & Therapeutics for Keratoderma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Keratoderma

Drug clinical trials:

Search ClinicalTrials for Keratoderma

Search NIH Clinical Center for Keratoderma

Search CenterWatch for Keratoderma

Genetic Tests for Keratoderma

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20GeneTests
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Genetic tests related to Keratoderma:

id Genetic test Affiliating Genes
1 Keratoderma20

Anatomical Context for Keratoderma

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32MalaCards
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MalaCards organs/tissues related to Keratoderma:

32
Skin

Animal Models for Keratoderma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Keratoderma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.8TGM1, DSP, GJB3, GJB2, KRT16, KRT1

Publications for Keratoderma

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Genetic Variations for Keratoderma

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Expression for genes affiliated with Keratoderma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratoderma

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Pathways for genes affiliated with Keratoderma

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53Reactome, 12EMD Millipore
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Pathways related to Keratoderma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4DSG1, DSP
210.1EVPL, KRT17, KRT1, KRT16, KRT6C, DSP

Compounds for genes affiliated with Keratoderma

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Keratoderma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1collodion4410.6TGM1, LOR
2epsilon-(gamma-glutamyl)lysine4410.6TGM1, LOR
3isotretinoin44 1111.6KRT16, KRT1, KRT10
4calcipotriol44 59 28 1113.6KRT16, KRT10, TGM1
5dithranol4410.6KRT10, KRT16
6sodium dodecylsulfate4410.5TGM1, KRT17, KRT1, KRT16
7hematoxylin4410.5KRT10, KRT1, LOR
8tazarotene44 1111.5KRT10, KRT1
9asparagine4410.5GJB2, KRT1, KRT17
10paraffin4410.5GJB2, KRT16, KRT1, KRT10, KRT17
11histidine4410.4LOR, CYGB, KRT10, KRT9
12retinoid4410.4GJB2, KRT16, KRT1, KRT10, KRT17, TGM1
13proline4410.4LOR, GJB3, GJB2, KRT16, KRT1, KRT10
14gap 275910.4GJB3, GJB2
151,25 dihydroxy vitamin d34410.4KRT16, KRT10, TGM1
16progesterone44 59 28 11 2414.4DSP, GJB2, KRT1, KRT10, TGM1
17steroid4410.4LOR, DSP, SLURP1, KRT16, KRT1, KRT10
18carbenoxolone disodium5910.3GJB3, GJB2
19octanol28 2411.3GJB2, GJB3
20retinoic acid44 2411.3TGM1, LOR, DSP, DSG1, GJB2, KRT16
21scrambled 10panx5910.2GJB3, GJB2
22serine4410.2KRT17, KRT10, KRT1, KRT16, DSG1, DSP
2310panx5910.0GJB3, GJB2

GO Terms for genes affiliated with Keratoderma

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16Gene Ontology
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Cellular components related to Keratoderma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1connexon complexGO:00592210.3GJB2, GJB3
2cornified envelopeGO:00153310.2LOR, DSP, EVPL, TGM1
3intermediate filamentGO:00588210.2KRT17, KRT9, KRT10, KRT16, KRT6C, DSP
4keratin filamentGO:04509510.1KRT6C, KRT1, KRT10, KRTAP11-1
5desmosomeGO:03005710.0EVPL, DSG1, DSP

Biological processes related to Keratoderma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:04510910.3KRT17, KRT9, DSP
2peptide cross-linkingGO:01814910.2LOR, DSP, EVPL, TGM1
3keratinocyte differentiationGO:03021610.2TGM1, EVPL, KRT10, DSP, LOR
4epidermis developmentGO:00854410.1DSP, KRT16, KRT9, KRT17, EVPL
5keratinizationGO:0314249.9TGM1, EVPL, KRT17, LOR

Molecular functions related to Keratoderma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gap junction channel activityGO:00524310.3GJB2, GJB3
2structural constituent of cytoskeletonGO:00520010.1LOR, DSP, KRT16, KRT9, KRT17
3structural molecule activityGO:00519810.1EVPL, KRTAP11-1, KRT1, KRT6C, DSP, LOR
4protein binding, bridgingGO:03067410.0EVPL, DSP, LOR

Products for genes affiliated with Keratoderma

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  • Antibodies
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Sources for Keratoderma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet