MCID: KRT023
MIFTS: 19

Keratoderma Palmoplantaris Transgrediens malady

Genetic diseases, Rare diseases, Skin diseases categories

Summaries for Keratoderma Palmoplantaris Transgrediens

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MalaCards based summary: Keratoderma Palmoplantaris Transgrediens, also known as keratosis palmoplantaris transgrediens et progrediens, is related to erythrokeratodermia variabilis et progressiva and keratoderma, and has symptoms including dry skin, palmoplantar keratoderma and hyperhidrosis. Affiliated tissues include skin.

Aliases & Classifications for Keratoderma Palmoplantaris Transgrediens

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Sources:
43NIH Rare Diseases, 49Orphanet, 62UMLS, 28ICD10 via Orphanet
See all sources

Keratoderma Palmoplantaris Transgrediens, Aliases & Descriptions:

Name: Keratoderma Palmoplantaris Transgrediens 43 62
Keratosis Palmoplantaris Transgrediens Et Progrediens 43 49 62
Greither Disease 43 49 62
Erythrokeratodermia Variabilis with Erythema Gyratum Repens 43 62
Transgrediens Et Progrediens Palmoplantar Keratoderma 43 49
Keratosis Extremitatum Hereditaria Progrediens 43 49
 
Progressive Diffuse Palmoplantar Keratoderma 43 49
Transgrediens Et Progrediens Ppk 43 49
Progressive Diffuse Ppk 43 49
Erythrokeratodermia Figurata, Congenital Familial, in Plaques 43
Greither's Disease 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Skin diseases
Orphanet: 49 
Rare skin diseases


External Ids:

Orphanet49 495
ICD10 via Orphanet28 Q82.8

Related Diseases for Keratoderma Palmoplantaris Transgrediens

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Diseases related to Keratoderma Palmoplantaris Transgrediens via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1erythrokeratodermia variabilis et progressiva10.7
2keratoderma10.1

Symptoms for Keratoderma Palmoplantaris Transgrediens

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Symptoms:

 49 (show all 10)
  • palmoplantar hyperkeratosis/keratoderma
  • dry/squaly skin/exfoliation
  • autosomal dominant inheritance
  • hyperhidrosis/increased sweating
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • thin/hypoplastic/hyperconvex fingernails
  • corneal dystrophy
  • hyperkeratosis/ainhum/hyperkeratotic skin fissures
  • alopecia
  • restricted joint mobility/joint stiffness/ankylosis

HPO human phenotypes related to Keratoderma Palmoplantaris Transgrediens:

(show all 7)
id Description Frequency HPO Source Accession
1 dry skin hallmark (90%) HP:0000958
2 palmoplantar keratoderma hallmark (90%) HP:0000982
3 hyperhidrosis typical (50%) HP:0000975
4 abnormality of the fingernails typical (50%) HP:0001231
5 corneal dystrophy occasional (7.5%) HP:0001131
6 limitation of joint mobility occasional (7.5%) HP:0001376
7 alopecia occasional (7.5%) HP:0001596

Drugs & Therapeutics for Keratoderma Palmoplantaris Transgrediens

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Drug clinical trials:

Search ClinicalTrials for Keratoderma Palmoplantaris Transgrediens

Search NIH Clinical Center for Keratoderma Palmoplantaris Transgrediens

Genetic Tests for Keratoderma Palmoplantaris Transgrediens

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Anatomical Context for Keratoderma Palmoplantaris Transgrediens

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MalaCards organs/tissues related to Keratoderma Palmoplantaris Transgrediens:

33
Skin

Animal Models for Keratoderma Palmoplantaris Transgrediens or affiliated genes

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Publications for Keratoderma Palmoplantaris Transgrediens

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Variations for Keratoderma Palmoplantaris Transgrediens

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Expression for genes affiliated with Keratoderma Palmoplantaris Transgrediens

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Search GEO for disease gene expression data for Keratoderma Palmoplantaris Transgrediens.

Pathways for genes affiliated with Keratoderma Palmoplantaris Transgrediens

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Compounds for genes affiliated with Keratoderma Palmoplantaris Transgrediens

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GO Terms for genes affiliated with Keratoderma Palmoplantaris Transgrediens

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Products for genes affiliated with Keratoderma Palmoplantaris Transgrediens

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Keratoderma Palmoplantaris Transgrediens

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet