MCID: KRT023
MIFTS: 16

Keratoderma Palmoplantaris Transgrediens malady

Genetic diseases, Rare diseases, Skin diseases categories

Aliases & Classifications for Keratoderma Palmoplantaris Transgrediens

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Sources:
42NIH Rare Diseases, 48Orphanet, 61UMLS, 26ICD10 via Orphanet
See all sources

Aliases & Descriptions for Keratoderma Palmoplantaris Transgrediens:

Name: Keratoderma Palmoplantaris Transgrediens 42 61
Greither Disease 42 48 61
Transgrediens Et Progrediens Palmoplantar Keratoderma 42 48
Keratosis Palmoplantaris Transgrediens Et Progrediens 42 48
Keratosis Extremitatum Hereditaria Progrediens 42 48
Progressive Diffuse Palmoplantar Keratoderma 42 48
 
Transgrediens Et Progrediens Ppk 42 48
Progressive Diffuse Ppk 42 48
Erythrokeratodermia Figurata, Congenital Familial, in Plaques 42
Erythrokeratodermia Variabilis with Erythema Gyratum Repens 42
Greither's Disease 42


Classifications:

Orphanet: 48 
Rare skin diseases


External Ids:

Orphanet48 495
ICD10 via Orphanet26 Q82.8

Summaries for Keratoderma Palmoplantaris Transgrediens

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MalaCards based summary: Keratoderma Palmoplantaris Transgrediens, also known as greither disease, is related to erythrokeratodermia variabilis et progressiva and keratoderma, and has symptoms including dry skin, palmoplantar keratoderma and hyperhidrosis. Affiliated tissues include skin.

Related Diseases for Keratoderma Palmoplantaris Transgrediens

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Diseases related to Keratoderma Palmoplantaris Transgrediens via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1erythrokeratodermia variabilis et progressiva10.4
2keratoderma10.1

Symptoms for Keratoderma Palmoplantaris Transgrediens

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Symptoms:

 48 (show all 10)
  • palmoplantar hyperkeratosis/keratoderma
  • dry/squaly skin/exfoliation
  • autosomal dominant inheritance
  • hyperhidrosis/increased sweating
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • thin/hypoplastic/hyperconvex fingernails
  • corneal dystrophy
  • hyperkeratosis/ainhum/hyperkeratotic skin fissures
  • alopecia
  • restricted joint mobility/joint stiffness/ankylosis

HPO human phenotypes related to Keratoderma Palmoplantaris Transgrediens:

(show all 7)
id Description Frequency HPO Source Accession
1 dry skin hallmark (90%) HP:0000958
2 palmoplantar keratoderma hallmark (90%) HP:0000982
3 hyperhidrosis typical (50%) HP:0000975
4 abnormality of the fingernails typical (50%) HP:0001231
5 corneal dystrophy occasional (7.5%) HP:0001131
6 limitation of joint mobility occasional (7.5%) HP:0001376
7 alopecia occasional (7.5%) HP:0001596

Drugs & Therapeutics for Keratoderma Palmoplantaris Transgrediens

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Drug clinical trials:

Search ClinicalTrials for Keratoderma Palmoplantaris Transgrediens

Search NIH Clinical Center for Keratoderma Palmoplantaris Transgrediens

Genetic Tests for Keratoderma Palmoplantaris Transgrediens

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Anatomical Context for Keratoderma Palmoplantaris Transgrediens

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MalaCards organs/tissues related to Keratoderma Palmoplantaris Transgrediens:

31
Skin

Animal Models for Keratoderma Palmoplantaris Transgrediens or affiliated genes

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Publications for Keratoderma Palmoplantaris Transgrediens

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Variations for Keratoderma Palmoplantaris Transgrediens

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Expression for genes affiliated with Keratoderma Palmoplantaris Transgrediens

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Search GEO for disease gene expression data for Keratoderma Palmoplantaris Transgrediens.

Pathways for genes affiliated with Keratoderma Palmoplantaris Transgrediens

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Compounds for genes affiliated with Keratoderma Palmoplantaris Transgrediens

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GO Terms for genes affiliated with Keratoderma Palmoplantaris Transgrediens

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Sources for Keratoderma Palmoplantaris Transgrediens

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet