VAD
MCID: KRT002
MIFTS: 46

Keratomalacia (VAD) malady

Rare diseases, Eye diseases categories

Summaries for Keratomalacia

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Sources:
35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Vitamin a plays a role in your vision bone growth reproduction cell functions immune system vitamin a is an antioxidant. it can come from plant or animal sources. plant sources include colorful fruits and vegetables. animal sources include liver and whole milk. vitamin a is also added to foods like cereals. vegetarians, young children, and alcoholics may need extra vitamin a. you might also need more if you have certain conditions, such as liver diseases, cystic fibrosis, and crohn's disease. check with your health care provider to see if you need to take vitamin a supplements. nih: national institutes of health office of dietary supplements

MalaCards: Keratomalacia, also known as vitamin a deficiency, is related to xerophthalmia and night blindness. An important gene associated with Keratomalacia is RHO (rhodopsin). The drugs cod liver oil and vitamin a and the compounds amine and acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and bone.

Wikipedia:66 Keratomalacia is an eye disorder that results from Vitamin A deficiency. Vitamin A is required to... more...

Aliases & Classifications for Keratomalacia

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 40NCBI Bookshelf, 35MedlinePlus, 36MeSH, 59SNOMED-CT, 28ICD9CM, 26ICD10
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Related Diseases for Keratomalacia

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Keratomalacia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 308)
idRelated DiseaseScoreTop Affiliating Genes
1xerophthalmia30.4RHO, DNASE1L1
2night blindness11.3
3congenital stationary night blindness11.2
4x-linked congenital stationary night blindness10.9
5retinitis10.7
6autosomal dominant congenital stationary night blindness10.6
7autosomal recessive congenital stationary night blindness10.5
8retinitis pigmentosa10.5
9hereditary night blindness10.5
10myopia10.5
11pityriasis rubra pilaris10.5
12leukemia10.4
13night blindness, congenital stationary , 1d, autosomal recessive10.4
14hypercarotenemia and vitamin a deficiency, autosomal dominant10.4
15amyloidosis10.4
16myeloma10.4
17al amyloidosis10.4
18acquired night blindness10.4
19chorioretinitis10.4
20oguchi disease 110.4
21congenital stationary night blindness, autosomal dominant 210.4
22congenital stationary night blindness, autosomal dominant 110.4
23night blindness, congenital stationary , 1e, autosomal recessive10.4
24multiple myeloma10.4
25plasma cell leukemia10.4
26fundus albipunctatus10.3
27congenital stationary night blindness, type 1b10.3
28congenital stationary night blindness, type 2b10.3
29congenital stationary night blindness, type 1c10.3
30night blindness, congenital stationary , 1a, x-linked10.3
31vascular dementia10.3
32dementia10.3
33bronchopulmonary dysplasia10.3
34choroideremia10.3
35melanoma10.3
36obesity10.3
37night blindness skeletal anomalies unusual facies10.3
38congenital stationary night blindness, type 1d10.3
39congenital stationary night blindness, type 1e10.3
40congenital stationary night blindness, type 1f10.3
41night blindness - skeletal anomalies - dysmorphism10.3
42leukoplakia10.3
43oral leukoplakia10.3
44pseudotumor cerebri10.2
45keratoconjunctivitis sicca10.2
46dermatitis10.2
47hepatitis10.2
48nephrotic syndrome10.2
49duchenne muscular dystrophy10.2
50primary biliary cirrhosis10.2

Graphical network of the top 20 diseases related to Keratomalacia:



Diseases related to keratomalacia

Symptoms for Keratomalacia

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Drugs & Therapeutics for Keratomalacia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Keratomalacia

Drug clinical trials:

Search ClinicalTrials for Keratomalacia

Search NIH Clinical Center for Keratomalacia

Search CenterWatch for Keratomalacia

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Keratomalacia

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Anatomical Context for Keratomalacia

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34MalaCards
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MalaCards organs/tissues related to Keratomalacia:

34
Eye, Liver, Bone, Pancreas, Skin

Animal Models for Keratomalacia or affiliated genes

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Publications for Keratomalacia

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Sources:
53PubMed
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Articles related to Keratomalacia:

(show top 50)    (show all 56)
idTitleAuthorsYear
1
Sociodemographic features and risk factor profile of keratomalacia in early infancy. (22406941)
2012
2
360-degree conjunctival grafting for management of diffuse keratomalacia in a dog. (21521447)
2011
3
Ciliary hypertrichosis in a child with keratomalacia. (21092399)
2010
4
Use of amniotic membrane graft and corneal transplantation in a patient with bilateral keratomalacia induced by uncontrolled phenylketonuria. (17525666)
2007
5
Keratomalacia caused by psychiatric-induced dietary restrictions. (17721303)
2007
6
Equine amniotic membrane transplantation for corneal ulceration and keratomalacia in three horses. (16178841)
2005
7
Keratomalacia in a neonate secondary to maternal vitamin A deficiency. (16272665)
2005
8
Advanced keratomalacia with descemetocele in an infant with cystic fibrosis. (16009849)
2005
9
Inflammatory stromal keratopathies: medical management of stromal keratomalacia, stromal abscesses, eosinophilic keratitis, and band keratopathy in the horse. (15271427)
2004
10
Keratoplasty for keratomalacia in preschool children. (12714386)
2003
11
Keratomalacia and scurvy in a severely malnourished infant. (11860588)
2002
12
Bilateral keratomalacia in a cachectic scleroderma patient. (10692938)
1999
13
Keratomalacia in northern Afghanistan. (17492034)
1998
14
A new classification system predicting keratomalacia after trauma in vitamin A deficiency: sodium citrate does not prevent disease progression. (9220247)
1997
15
Xerophthalmia, keratomalacia and nutritional blindness. (2188921)
1990
16
Keratomalacia in a child with familial hypo-retinol-binding proteinemia. (3148050)
1988
17
Keratomalacia in Soyal fed infants. (3448023)
1987
18
Keratomalacia on a 'healthy diet'. (3516209)
1986
19
Vitamin A to prevent keratomalacia. (6149410)
1984
20
Nutritional factors in corneal xerophthalmia and keratomalacia. (7065955)
1982
21
Corneal xerophthalmia and keratomalacia. (7065956)
1982
22
Keratomalacia in acrodermatitis enteropathica (AE). (6796792)
1981
23
A case of total keratomalacia due to soft contact lens wearing. (7013624)
1980
24
Role of vitamin A deficiency and protein-calorie malnutrition in keratomalacia and Bitot's spots (A clinicopathologic study). (120319)
1979
25
Keratomalacia in the cachectic hospitalized patient. (986773)
1976
26
Keratomalacia. (1081744)
1975
27
Mass distribution of vitamin A and the prevention of keratomalacia. (1200101)
1975
28
Therapeutic penetrating keratoplasty in keratomalacia. (4585797)
1973
29
Keratomalacia in Haiti. (4647770)
1972
30
Clinical aspects of keratomalacia. (4647768)
1972
31
Clinical aspects of keratomalacia. (4630594)
1972
32
Surgical treatment of active keratomalacia by "covering graft". (4567293)
1972
33
Keratomalacia and intestinal helminthiasis. (4644282)
1972
34
Clinical aspects of keratomalacia. (4630593)
1972
35
Serum proteins in kwashiorkor and marasmus. 4. Cases with or without keratomalacia. (5401879)
1969
36
Necrotizing keratitis (keratomalacia) with corneal perforation and expulsive uveal hemorrhage in a new-born. (5755680)
1968
37
The evolution of keratomalacia. (5255226)
1967
38
Keratomalacia: a review of its relationship to xerophthalmia and its response to treatment. (6037438)
1967
39
Xerophthalmia (keratomalacia) in Singapore--a study. (5587801)
1967
40
Keratomalacia following senile cataract extraction. (5830426)
1965
41
KERATOMALACIA IN KWASHIORKOR AND MARASMUS. (14281021)
1964
42
Protein deficiency in keratomalacia. (13364173)
1956
43
Keratomalacia: causes, diagnosis, treatment and prevention. (13212074)
1954
44
Keratomalacia and panophthalmitis in yellow mice. (13092229)
1953
45
A CASE OF KERATOMALACIA CURED BY PENICILLIN AND VITAMIN A. (18170469)
1948
46
Xerophthalmia and keratomalacia in children. (20257859)
1947
47
ON THE PIGMENTATION OF THE CONJUNCTIVA IN NORMAL INDIVIDUALS AND IN CASES OF KERATOMALACIA IN ADULTS. (18168928)
1931
48
AN INQUIRY INTO THE ORIGIN OF THE ABNORMAL PIGMENTATION OF THE SKIN AND CONJUNCTIVA IN CASES OF KERATOMALACIA IN ADULTS. (18168824)
1929
49
KERATOMALACIA IN SOUTHERN INDIA. (18168192)
1922
50
A Contribution to the Study of Keratomalacia among Rats. (16742953)
1920

Variations for Keratomalacia

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Expression for genes affiliated with Keratomalacia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratomalacia

Search GEO for disease gene expression data for Keratomalacia.

Pathways for genes affiliated with Keratomalacia

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Compounds for genes affiliated with Keratomalacia

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Sources:
46Novoseek, 52PharmGKB, 30IUPHAR, 25HMDB, 12DrugBank
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Compounds related to Keratomalacia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1amine469.2QDPR, RHO
2acetylcholine46 52 30 25 1213.2QDPR, RHO
3gtp46 3010.1QDPR, RHO
4hydrogen46 2510.1QDPR, RHO
5dopamine46 30 25 1212.0RHO, QDPR
6lipid469.0QDPR, RHO
7threonine468.9QDPR, RHO
8alanine468.7QDPR, RHO

GO Terms for genes affiliated with Keratomalacia

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Products for genes affiliated with Keratomalacia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Keratomalacia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet