VAD
MCID: KRT002
MIFTS: 47

Keratomalacia (VAD) malady

Metabolic diseases category

Summaries for Keratomalacia

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Vitamin a plays a role in your vision bone growth reproduction cell functions immune system vitamin a is an antioxidant. it can come from plant or animal sources. plant sources include colorful fruits and vegetables. animal sources include liver and whole milk. vitamin a is also added to foods like cereals. vegetarians, young children, and alcoholics may need extra vitamin a. you might also need more if you have certain conditions, such as liver diseases, cystic fibrosis, and crohn's disease. check with your health care provider to see if you need to take vitamin a supplements. nih: national institutes of health office of dietary supplements

MalaCards: Keratomalacia, also known as vitamin a deficiency, is related to night blindness and xerophthalmia. An important gene associated with Keratomalacia is RHO (rhodopsin). The drugs cod liver oil and vitamin a and the compounds amine and acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include liver, eye and bone.

Wikipedia:63 Keratomalacia is an eye disorder that results from Vitamin A deficiency. Vitamin A is required to... more...

Aliases & Classifications for Keratomalacia

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 38NCBI Bookshelf, 33MedlinePlus, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Related Diseases for Keratomalacia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Keratomalacia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 301)
idRelated DiseaseScoreTop Affiliating Genes
1night blindness31.9RHO
2xerophthalmia30.5DNASE1L1, RHO
3congenital stationary night blindness11.1
4x-linked congenital stationary night blindness10.7
5retinitis10.6
6hereditary night blindness10.6
7acquired night blindness10.5
8retinitis pigmentosa10.5
9autosomal dominant congenital stationary night blindness10.5
10autosomal recessive congenital stationary night blindness10.5
11myopia10.4
12pityriasis rubra pilaris10.4
13leukemia10.4
14night blindness, congenital stationary , 1d, autosomal recessive10.4
15hypercarotenemia and vitamin a deficiency, autosomal dominant10.4
16amyloidosis10.4
17myeloma10.4
18chorioretinitis10.3
19oguchi disease 110.3
20congenital stationary night blindness, autosomal dominant 210.3
21congenital stationary night blindness, autosomal dominant 110.3
22night blindness, congenital stationary , 1e, autosomal recessive10.3
23multiple myeloma10.3
24fundus albipunctatus10.3
25choroideremia10.3
26congenital stationary night blindness, type 1b10.3
27congenital stationary night blindness, type 2b10.3
28congenital stationary night blindness, type 1c10.3
29night blindness, congenital stationary , 1a, x-linked10.3
30vascular dementia10.3
31dementia10.3
32color blindness10.2
33melanoma10.2
34obesity10.2
35night blindness skeletal anomalies unusual facies10.2
36congenital stationary night blindness, type 1d10.2
37congenital stationary night blindness, type 1e10.2
38congenital stationary night blindness, type 1f10.2
39night blindness - skeletal anomalies - dysmorphism10.2
40hypervitaminosis a10.2
41pseudotumor cerebri10.2
42keratoconjunctivitis sicca10.2
43hepatitis a10.2
44dermatitis10.2
45hepatitis10.2
46nephrotic syndrome10.2
47abetalipoproteinemia10.2
48diarrhea10.2
49photosensitivity disease10.2
50gyrate atrophy10.1

Graphical network of the top 20 diseases related to Keratomalacia:



Diseases related to keratomalacia

Clinical Features for Keratomalacia

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Drugs & Therapeutics for Keratomalacia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Keratomalacia

Drug clinical trials:

Search ClinicalTrials for Keratomalacia

Search NIH Clinical Center for Keratomalacia

Search CenterWatch for Keratomalacia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Keratomalacia

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Anatomical Context for Keratomalacia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Keratomalacia:

32
Liver, Eye, Bone, Pancreas, Skin

Animal Models for Keratomalacia or affiliated genes

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Publications for Keratomalacia

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Sources:
50PubMed
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Articles related to Keratomalacia:

(show top 50)    (show all 58)
idTitleAuthorsYear
1
Sociodemographic features and risk factor profile of keratomalacia in early infancy. (22406941)
2012
2
Ciliary hypertrichosis in a child with keratomalacia. (21092399)
2010
3
Use of amniotic membrane graft and corneal transplantation in a patient with bilateral keratomalacia induced by uncontrolled phenylketonuria. (17525666)
2007
4
Keratomalacia caused by psychiatric-induced dietary restrictions. (17721303)
2007
5
Equine amniotic membrane transplantation for corneal ulceration and keratomalacia in three horses. (16178841)
2005
6
Keratomalacia in a neonate secondary to maternal vitamin A deficiency. (16272665)
2005
7
Advanced keratomalacia with descemetocele in an infant with cystic fibrosis. (16009849)
2005
8
Inflammatory stromal keratopathies: medical management of stromal keratomalacia, stromal abscesses, eosinophilic keratitis, and band keratopathy in the horse. (15271427)
2004
9
Bilateral keratomalacia in a cachectic scleroderma patient. (10692938)
1999
10
Keratomalacia in northern Afghanistan. (17492034)
1998
11
A new classification system predicting keratomalacia after trauma in vitamin A deficiency: sodium citrate does not prevent disease progression. (9220247)
1997
12
Xerophthalmia, keratomalacia and nutritional blindness. (2188921)
1990
13
Keratomalacia in a child with familial hypo-retinol-binding proteinemia. (3148050)
1988
14
Keratomalacia in Soyal fed infants. (3448023)
1987
15
Keratomalacia in Soyal fed infants. (3692597)
1987
16
Keratomalacia on a 'healthy diet'. (3516209)
1986
17
Vitamin A to prevent keratomalacia. (6149410)
1984
18
Nutritional factors in corneal xerophthalmia and keratomalacia. (7065955)
1982
19
Corneal xerophthalmia and keratomalacia. (7150067)
1982
20
Keratomalacia in acrodermatitis enteropathica (AE). (6796792)
1981
21
A case of total keratomalacia due to soft contact lens wearing. (7013624)
1980
22
Role of vitamin A deficiency and protein-calorie malnutrition in keratomalacia and Bitot's spots (A clinicopathologic study). (120319)
1979
23
Management of keratomalacia. (670739)
1978
24
Keratomalacia in the cachectic hospitalized patient. (986773)
1976
25
Keratomalacia. (1081744)
1975
26
Mass distribution of vitamin A and the prevention of keratomalacia. (1200101)
1975
27
Therapeutic penetrating keratoplasty in keratomalacia. (4585797)
1973
28
Keratomalacia in Haiti. (4647770)
1972
29
Clinical aspects of keratomalacia. (4647768)
1972
30
Clinical aspects of keratomalacia. (4630594)
1972
31
Surgical treatment of active keratomalacia by "covering graft". (4567293)
1972
32
Keratomalacia and intestinal helminthiasis. (4644282)
1972
33
Clinical aspects of keratomalacia. (4630593)
1972
34
Serum proteins in kwashiorkor and marasmus. 4. Cases with or without keratomalacia. (5401879)
1969
35
Necrotizing keratitis (keratomalacia) with corneal perforation and expulsive uveal hemorrhage in a new-born. (5755680)
1968
36
The evolution of keratomalacia. (5255226)
1967
37
Keratomalacia: a review of its relationship to xerophthalmia and its response to treatment. (6037438)
1967
38
Intestinal infections and ocular lesions with particular reference to Keratomalacia. (5912095)
1966
39
The influence of protein on keratomalacia. I. Dietary condition of keratomalacia cases. (5914701)
1966
40
Keratomalacia following senile cataract extraction. (5830426)
1965
41
KERATOMALACIA IN KWASHIORKOR AND MARASMUS. (14281021)
1964
42
Keratomalacia: causes, diagnosis, treatment and prevention. (13212074)
1954
43
Keratomalacia and panophthalmitis in yellow mice. (13092229)
1953
44
A CASE OF KERATOMALACIA CURED BY PENICILLIN AND VITAMIN A. (18170469)
1948
45
Xerophthalmia and keratomalacia in children. (20257859)
1947
46
Keratomalacia and Cystic Fibrosis of the Pancreas. (16693182)
1939
47
ON THE PIGMENTATION OF THE CONJUNCTIVA IN NORMAL INDIVIDUALS AND IN CASES OF KERATOMALACIA IN ADULTS. (18168928)
1931
48
AN INQUIRY INTO THE ORIGIN OF THE ABNORMAL PIGMENTATION OF THE SKIN AND CONJUNCTIVA IN CASES OF KERATOMALACIA IN ADULTS. (18168824)
1929
49
KERATOMALACIA IN SOUTHERN INDIA. (18168192)
1922
50
A Contribution to the Study of Keratomalacia among Rats. (16742953)
1920

Genetic Variations for Keratomalacia

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Expression for genes affiliated with Keratomalacia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratomalacia

Search GEO for disease gene expression data for Keratomalacia.

Pathways for genes affiliated with Keratomalacia

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Compounds for genes affiliated with Keratomalacia

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Keratomalacia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1amine449.2QDPR, RHO
2acetylcholine44 49 28 11 2413.1QDPR, RHO
3gtp44 2810.1QDPR, RHO
4hydrogen44 2410.0RHO, QDPR
5alanine449.0QDPR, RHO
6dopamine44 28 11 2411.9QDPR, RHO
7threonine448.7QDPR, RHO

GO Terms for genes affiliated with Keratomalacia

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Products for genes affiliated with Keratomalacia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Keratomalacia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet