VAD
MCID: KRT002
MIFTS: 42

Keratomalacia (VAD) malady

Metabolic category

Summaries for Keratomalacia

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 Vitamin a plays a role in your vision bone growth reproduction cell functions immune system vitamin a is an antioxidant. it can come from plant or animal sources. plant sources include colorful fruits and vegetables. animal sources include liver and whole milk. vitamin a is also added to foods like cereals. vegetarians, young children, and alcoholics may need extra vitamin a. you might also need more if you have certain conditions, such as liver diseases, cystic fibrosis, and crohn's disease. check with your health care provider to see if you need to take vitamin a supplements. nih: national institutes of health office of dietary supplements

MalaCards: Keratomalacia, also known as vitamin a deficiency, is related to xerophthalmia and blindness. An important gene associated with Keratomalacia is RHO (rhodopsin). The drugs cod liver oil and vitamin a and the compounds amine and acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and skin.

Wikipedia:64 Keratomalacia is an eye disorder that results from Vitamin A deficiency. Vitamin A is required to... more...

Aliases & Classifications for Keratomalacia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 39NCBI Bookshelf, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Related Diseases for Keratomalacia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Keratomalacia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 242)
idRelated DiseaseScoreTop Affiliating Genes
1xerophthalmia30.5DNASE1L1, RHO
2blindness29.9RHO
3congenital stationary night blindness11.1
4x-linked congenital stationary night blindness10.8
5autosomal dominant congenital stationary night blindness10.6
6hereditary night blindness10.6
7acquired night blindness10.5
8retinitis pigmentosa10.5
9pityriasis rubra pilaris10.4
10n syndrome10.4
11amyloidosis10.4
12congenital stationary night blindness, autosomal dominant 210.4
13congenital stationary night blindness, autosomal dominant 110.4
14night blindness, congenital stationary , 1d, autosomal recessive10.4
15night blindness, congenital stationary , 1e, autosomal recessive10.4
16t-cell leukemia10.4
17plasma cell leukemia10.4
18fundus albipunctatus10.3
19oguchi disease 110.3
20congenital stationary night blindness, type 1b10.3
21congenital stationary night blindness, type 2b10.3
22congenital stationary night blindness, type 1c10.3
23night blindness, congenital stationary , 1a, x-linked10.3
24vascular dementia10.3
25hypercarotenemia and vitamin a deficiency, autosomal dominant10.3
26bronchopulmonary dysplasia10.3
27night blindness skeletal anomalies unusual facies10.3
28congenital stationary night blindness, type 1d10.3
29congenital stationary night blindness, type 1e10.3
30congenital stationary night blindness, type 1f10.3
31night blindness - skeletal anomalies - dysmorphism10.3
32leukoplakia10.2
33oral leukoplakia10.2
34hypervitaminosis d10.2
35pseudotumor cerebri10.2
36keratoconjunctivitis sicca10.2
37gyrate atrophy10.2
38leber congenital amaurosis10.2
39primary biliary cirrhosis10.2
40duchenne muscular dystrophy10.2
41congenital nystagmus10.2
42cone-rod dystrophy 210.2
43cacna1f-related x-linked congenital stationary night blindness10.2
44nyx-related x-linked congenital stationary night blindness10.2
45night blindness, congenital stationary , 1f, autosomal recessive10.2
46night blindness, congenital stationary , 1b, autosomal recessive10.2
47retinitis pigmentosa 6410.2
48night blindness, congenital stationary , 2b, autosomal recessive10.2
49night blindness, congenital stationary , 1c, autosomal recessive10.2
50night blindness, congenital stationary , 2a, x-linked10.2

Graphical network of the top 20 diseases related to Keratomalacia:



Diseases related to keratomalacia

Clinical Features for Keratomalacia

Drugs & Therapeutics for Keratomalacia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Keratomalacia

Drug clinical trials:

Search ClinicalTrials for Keratomalacia

Search NIH Clinical Center for Keratomalacia

Search CenterWatch for Keratomalacia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Keratomalacia

Anatomical Context for Keratomalacia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Keratomalacia:

33
Liver, Pancreas, Skin

Animal Models for Keratomalacia or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Keratomalacia

Sources:
51PubMed
See all sources

Articles related to Keratomalacia:

(show top 50)    (show all 58)
idTitleAuthorsYear
1
Sociodemographic features and risk factor profile of keratomalacia in early infancy. (22406941)
2012
2
360-degree conjunctival grafting for management of diffuse keratomalacia in a dog. (21521447)
2011
3
Ciliary hypertrichosis in a child with keratomalacia. (21092399)
2010
4
Use of amniotic membrane graft and corneal transplantation in a patient with bilateral keratomalacia induced by uncontrolled phenylketonuria. (17525666)
2007
5
Keratomalacia caused by psychiatric-induced dietary restrictions. (17721303)
2007
6
Equine amniotic membrane transplantation for corneal ulceration and keratomalacia in three horses. (16178841)
2005
7
Keratomalacia in a neonate secondary to maternal vitamin A deficiency. (16272665)
2005
8
Inflammatory stromal keratopathies: medical management of stromal keratomalacia, stromal abscesses, eosinophilic keratitis, and band keratopathy in the horse. (15271427)
2004
9
Keratoplasty for keratomalacia in preschool children. (12714386)
2003
10
Keratomalacia and scurvy in a severely malnourished infant. (11860588)
2002
11
Bilateral keratomalacia in a cachectic scleroderma patient. (10692938)
1999
12
Keratomalacia in northern Afghanistan. (17492034)
1998
13
A new classification system predicting keratomalacia after trauma in vitamin A deficiency: sodium citrate does not prevent disease progression. (9220247)
1997
14
Bilateral severe keratomalacia after acute pancreatitis. (8500326)
1993
15
Xerophthalmia, keratomalacia and nutritional blindness. (2188921)
1990
16
Keratomalacia in a child with familial hypo-retinol-binding proteinemia. (3148050)
1988
17
Keratomalacia in Soyal fed infants. (3448023)
1987
18
Keratomalacia in Soyal fed infants. (3692597)
1987
19
Keratomalacia on a 'healthy diet'. (3516209)
1986
20
Vitamin A to prevent keratomalacia. (6149410)
1984
21
Corneal xerophthalmia and keratomalacia. (7065956)
1982
22
Keratomalacia in acrodermatitis enteropathica (AE). (6796792)
1981
23
A case of total keratomalacia due to soft contact lens wearing. (7013624)
1980
24
Role of vitamin A deficiency and protein-calorie malnutrition in keratomalacia and Bitot's spots (A clinicopathologic study). (120319)
1979
25
Management of keratomalacia. (670739)
1978
26
Keratomalacia in the cachectic hospitalized patient. (986773)
1976
27
Keratomalacia. (1081744)
1975
28
Mass distribution of vitamin A and the prevention of keratomalacia. (1200101)
1975
29
Therapeutic penetrating keratoplasty in keratomalacia. (4585797)
1973
30
Keratomalacia in Haiti. (4647770)
1972
31
Clinical aspects of keratomalacia. (4647768)
1972
32
Clinical aspects of keratomalacia. (4630594)
1972
33
Keratomalacia and intestinal helminthiasis. (4644282)
1972
34
Serum proteins in kwashiorkor and marasmus. 4. Cases with or without keratomalacia. (5401879)
1969
35
Necrotizing keratitis (keratomalacia) with corneal perforation and expulsive uveal hemorrhage in a new-born. (5755680)
1968
36
Keratomalacia: a review of its relationship to xerophthalmia and its response to treatment. (6037438)
1967
37
Xerophthalmia (keratomalacia) in Singapore--a study. (5587801)
1967
38
The influence of protein on keratomalacia. I. Dietary condition of keratomalacia cases. (5914701)
1966
39
The influence of protein on keratomalacia. II. Experimental observation in albino rats. (5975752)
1966
40
Keratomalacia following senile cataract extraction. (5830426)
1965
41
Protein deficiency in keratomalacia. (13364173)
1956
42
Keratomalacia: causes, diagnosis, treatment and prevention. (13212074)
1954
43
Keratomalacia and panophthalmitis in yellow mice. (13092229)
1953
44
A CASE OF KERATOMALACIA CURED BY PENICILLIN AND VITAMIN A. (18170469)
1948
45
Xerophthalmia and keratomalacia in children. (20257859)
1947
46
Keratomalacia and Cystic Fibrosis of the Pancreas. (16693182)
1939
47
ON THE PIGMENTATION OF THE CONJUNCTIVA IN NORMAL INDIVIDUALS AND IN CASES OF KERATOMALACIA IN ADULTS. (18168928)
1931
48
AN INQUIRY INTO THE ORIGIN OF THE ABNORMAL PIGMENTATION OF THE SKIN AND CONJUNCTIVA IN CASES OF KERATOMALACIA IN ADULTS. (18168824)
1929
49
KERATOMALACIA IN SOUTHERN INDIA. (18168192)
1922
50
A Contribution to the Study of Keratomalacia among Rats. (16742953)
1920

Genetic Variations for Keratomalacia

Expression for genes affiliated with Keratomalacia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Keratomalacia

Search GEO for disease gene expression data for Keratomalacia.

Pathways for genes affiliated with Keratomalacia

Compounds for genes affiliated with Keratomalacia

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Keratomalacia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1amine459.2RHO, QDPR
2acetylcholine45 50 29 11 2413.1QDPR, RHO
3gtp45 2910.1QDPR, RHO
4hydrogen45 2410.0RHO, QDPR
5alanine459.0RHO, QDPR
6dopamine45 29 11 2411.9QDPR, RHO
7threonine458.7RHO, QDPR

GO Terms for genes affiliated with Keratomalacia

Products for genes affiliated with Keratomalacia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Keratomalacia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet