Aliases & Classifications for Keratopathy

Aliases & Descriptions for Keratopathy:

Name: Keratopathy 38 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2283
NCIt 47 C27012
UMLS 69 C0235270

Summaries for Keratopathy

MalaCards based summary : Keratopathy is related to limbal stem cell deficiency and bullous keratopathy. An important gene associated with Keratopathy is PAX6 (Paired Box 6), and among its related pathways/superpathways are Degradation of the extracellular matrix and ECM-receptor interaction. The drugs Pharmaceutical Solutions and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and t cells, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Keratopathy

Diseases related to Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
id Related Disease Score Top Affiliating Genes
1 limbal stem cell deficiency 26.8 AIRE AKR1B1 BMP4 FBN1 IGF1 IL1A
2 bullous keratopathy 12.4
3 band keratopathy 12.3
4 neurotrophic keratopathy 11.9
5 corneal intraepithelial dyskeratosis and ectodermal dysplasia 10.8
6 endotheliitis 10.3
7 renovascular hypertension 10.1 IL1A VCAM1
8 neuropathy, hereditary sensory and autonomic, type vi 10.1 BMP4 FBN1
9 keratitis 10.1
10 hypotrichosis 4 10.1 AIRE IL1A
11 drug psychosis 10.1 IL1A TAC1
12 ring dermoid of cornea 10.0 BMP4 PAX6
13 cataract 10.0
14 aniridia 10.0
15 aortic aneurysm, familial thoracic 6 10.0 IL1A TNC VCAM1
16 lacrimal duct obstruction 9.9 IGF1 PAX6
17 lymphedema 9.9 IL1A KRT12 VCAM1
18 lagophthalmos 9.9
19 keratoconus 9.9
20 multiple myeloma 9.9
21 contact lens corneal edema 9.8 BMP4 FBN1 IL1A NID1 TNC
22 fuchs' endothelial dystrophy 9.8
23 thymus adenosquamous carcinoma 9.8 IGF1 IL1A PAX6
24 citrullinemia, type ii, neonatal-onset 9.8 AKR1B1 IGF1 VCAM1
25 stomach carcinoma in situ 9.8 IGF1 IL1A
26 herpes zoster 9.8
27 corneal disease 9.7
28 herpes simplex 9.7
29 astigmatism 9.6
30 mycobacterium abscessus 9.6
31 kawasaki disease 9.6
32 xerophthalmia 9.6
33 myopia 9.6
34 fabry disease 9.6
35 corneal degeneration 9.6
36 cystinosis 9.6
37 stromal keratitis 9.6
38 arthritis 9.6
39 uveitis 9.6
40 leprosy 9.6
41 strabismus 9.6
42 crohn's disease 9.6
43 scleritis 9.6
44 hyperparathyroidism 9.6
45 keratomalacia 9.6
46 corneal neovascularization 9.6
47 lymphoma 9.6
48 choroiditis 9.6
49 corneal ulcer 9.6
50 ptosis 9.6

Graphical network of the top 20 diseases related to Keratopathy:



Diseases related to Keratopathy

Symptoms & Phenotypes for Keratopathy

MGI Mouse Phenotypes related to Keratopathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 AIRE AKR1B1 BMP4 FBN1 NID1 PAX6
2 homeostasis/metabolism MP:0005376 10.02 VCAM1 AIRE AKR1B1 BMP4 FBN1 IGF1
3 cardiovascular system MP:0005385 10.01 VCAM1 BMP4 FBN1 IGF1 IL1A NID1
4 integument MP:0010771 9.8 BMP4 FBN1 IGF1 IL1A PAX6 TAC1
5 no phenotypic analysis MP:0003012 9.73 AIRE BMP4 FBN1 KRT12 TNC VCAM1
6 normal MP:0002873 9.7 AIRE BMP4 IGF1 KRT12 PAX6 TAC1
7 renal/urinary system MP:0005367 9.43 AKR1B1 BMP4 FBN1 IGF1 PAX6 TAC1
8 vision/eye MP:0005391 9.1 AIRE AKR1B1 BMP4 KRT12 NID1 PAX6

Drugs & Therapeutics for Keratopathy

Drugs for Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 89)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
2
Acetylcholine Approved Phase 2, Phase 3 51-84-3 187
3 abobotulinumtoxinA Phase 2, Phase 3
4 Botulinum Toxins Phase 2, Phase 3
5 Botulinum Toxins, Type A Phase 2, Phase 3
6 Cholinergic Agents Phase 2, Phase 3
7 incobotulinumtoxinA Phase 2, Phase 3
8 Neuromuscular Agents Phase 2, Phase 3
9 Neurotransmitter Agents Phase 2, Phase 3
10 onabotulinumtoxinA Phase 2, Phase 3
11 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1
12 Ophthalmic Solutions Phase 3,Phase 1,Phase 2
13 Tetrahydrozoline Phase 3,Phase 1,Phase 2
14
Bevacizumab Approved, Investigational Phase 2 216974-75-3
15
Fluorometholone Approved Phase 2 426-13-1 9878
16
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
17
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
18
Ephedrine Approved Phase 1, Phase 2 299-42-3 9294
19
Pseudoephedrine Approved Phase 1, Phase 2 90-82-4 7028
20
Ambroxol Approved Phase 1, Phase 2 18683-91-5
21 Angiogenesis Inhibitors Phase 2
22 Angiogenesis Modulating Agents Phase 2
23 Antibodies Phase 2
24 Antibodies, Monoclonal Phase 2
25 Endothelial Growth Factors Phase 2
26 Immunoglobulins Phase 2
27 Mitogens Phase 2
28 Anesthetics Phase 2
29 Anti-Allergic Agents Phase 2
30 Antiemetics Phase 2
31 Anti-Inflammatory Agents Phase 2
32 Antineoplastic Agents, Hormonal Phase 2
33 Autonomic Agents Phase 2,Phase 1
34 Gastrointestinal Agents Phase 2
35 glucocorticoids Phase 2
36 Hormone Antagonists Phase 2
37 Hormones Phase 2
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
39 Methylprednisolone acetate Phase 2
40 Methylprednisolone Hemisuccinate Phase 2
41 Neuroprotective Agents Phase 2
42 Prednisolone acetate Phase 2
43 Prednisolone hemisuccinate Phase 2
44 Prednisolone phosphate Phase 2
45 Protective Agents Phase 2
46 Nasal Decongestants Phase 1, Phase 2
47 Respiratory System Agents Phase 1, Phase 2
48 Vasoconstrictor Agents Phase 1, Phase 2
49 Expectorants Phase 1, Phase 2
50 Anti-Infective Agents Phase 1, Phase 2

Interventional clinical trials:

(show all 37)
id Name Status NCT ID Phase
1 Study of the Presence and Extent of Corneal Disturbance Associated With B+L Biotrue MPS Used With B+L PureVision Lenses Completed NCT01268306 Phase 4
2 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3
3 Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1 Recruiting NCT02600429 Phase 3
4 Stem Cells Treatment for Bilateral Limbic Associated Keratopathy (HULPOFT) Unknown status NCT01808378 Phase 2
5 Bevacizumab for the Treatment of Corneal Neovascularization Unknown status NCT00992849 Phase 2
6 Amniotic Membrane Graft In Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
7 Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK) Completed NCT01448213 Phase 2
8 Utilization of Amniotic Membrane Extract Eye Drop (AMEED) on Human Corneal Healing Completed NCT02746848 Phase 1, Phase 2
9 Effects of Oral Mucolytics on Tear Film and Ocular Surface Completed NCT01713179 Phase 1, Phase 2
10 A Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy Recruiting NCT03084861 Phase 1, Phase 2
11 Study Evaluating Efficacy and Safety of SAR566658 Treatment in Patients With CA6 Positive Metastatic Triple Negative Breast Cancer Recruiting NCT02984683 Phase 2
12 Study of Ataluren in Patients With Aniridia Recruiting NCT02647359 Phase 2
13 Pain and Visual Outcome in Intravitreal Bevacizumab Injection Enrolling by invitation NCT02790775 Phase 2
14 A Randomized, Controlled, Double-Masked, Clinical Trial of Autologous Serum Eye Drops for Severe Ocular Chronic Graft-versus-Host Disease (GVHD) in Hematopoietic Stem Cell Transplant (HSCT) Patients Terminated NCT01972438 Phase 2
15 A Study of SAR428926 in Patients With Advanced Solid Tumors Recruiting NCT02575781 Phase 1
16 Assessment of Any Potential Retinal Effects of Tafenoquine (TQ) Active, not recruiting NCT02658435 Phase 1
17 Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media Unknown status NCT00623584
18 Comparing Endoglide to Endoserter for DSAEK Graft Insertion Unknown status NCT01791075
19 Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252
20 Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT02020044
21 Amniotic Membrane and Anterior Stromal Puncture to the Treatment of Symptomatic Bullous Keratopathy Completed NCT00659308
22 The Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking on the Signs and Symptoms of Bullous Keratopathy Completed NCT01106274
23 Automated Lamellar Keratectomy in Symptomatic Patients With Bullous Keratopathy Completed NCT00654888
24 The SNEC DSAEK EndoGlide Clinical Trial Completed NCT01122043
25 Eyelash Line Resection for Entropion Associated With Down's Syndrome Completed NCT01758718
26 A Comparison of Hydrogel Dressings and Ocular Lubricants in the Prevention on Corneal Damage in the Critically Ill Completed NCT00513734
27 Safety and Effectiveness of Subconjunctival Injection of Bevacizumab in the Treatment of Corneal Neovasculization Completed NCT00681603
28 Comparison of Patient Comfort After Two Anesthetic Protocols for Injections Into the Eye Completed NCT01087489
29 Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis Completed NCT00987467
30 Correlation of Gene Abnormalities and Clinical Manifestations of Aniridia Completed NCT00265590
31 Blood Based Eyedrops From Different Sources in the Treatment of Severe Keratopathy Recruiting NCT03064984
32 Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Recruiting NCT02660151
33 Staged and Combined Surgery for Cataract Patients With Corneal Endothelial Dysfunction Recruiting NCT02523950
34 Study of Endothelial Keratoplasty Outcomes Recruiting NCT00800111
35 Corneal Transplantation Guided by OCT RESCAN Not yet recruiting NCT02736877
36 Comparison of Aqueous and Plasma Glucose Level in Diabetic Patients Not yet recruiting NCT02750098
37 Topical Steroid Treatment After Posterior Lamellar Corneal Transplantation Withdrawn NCT01682421

Search NIH Clinical Center for Keratopathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Keratopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Keratopathy:
Adipose-derived stem cells for treatment of bilateral limbic-associated keratopathy
Embryonic/Adult Cultured Cells Related to Keratopathy:
Adipose-derived stem cells

Genetic Tests for Keratopathy

Anatomical Context for Keratopathy

MalaCards organs/tissues related to Keratopathy:

39
Endothelial, Eye, T Cells, Testes, Myeloid, B Cells, Brain

Publications for Keratopathy

Articles related to Keratopathy:

(show top 50) (show all 727)
id Title Authors Year
1
Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma. ( 28079685 )
2017
2
In vivo confocal microscopy of toxic keratopathy. ( 27740620 )
2017
3
Refractory Tamoxifen-Induced Keratopathy Despite Drug Withdrawal. ( 27918356 )
2016
4
Prosthetic Replacement of the Ocular Surface Ecosystem Scleral Lens Therapy for Exposure Keratopathy. ( 27171131 )
2016
5
Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells. ( 27077448 )
2016
6
Tegaderm(TM)dressing and Lacri-lube ointment moisture chamber to manage exposure keratopathy. ( 27769340 )
2016
7
Descemet Stripping Automated Endothelial Keratoplasty in Fuchs' Endothelial Dystrophy versus Pseudophakic Bullous Keratopathy. ( 27994806 )
2016
8
The benefit of preventing exposure keratopathy in icu patient: a case report. ( 27217884 )
2016
9
Thymosin Beta 4: A Potential Novel Therapy for Neurotrophic Keratopathy, Dry Eye, and Ocular Surface Diseases. ( 27450739 )
2016
10
Non-Descemet Stripping Automated Endothelial Keratoplasty for Bullous Keratopathy in Buphthalmic Eye. ( 27462256 )
2016
11
Toxic Keratopathy Following the Use of Alcohol-Containing Antiseptics in Nonocular Surgery. ( 26913777 )
2016
12
Crystalline keratopathy due to intravenous immunoglobulin in a 12-year-old girl with Kawasaki disease. ( 27667371 )
2016
13
Post-septal upper eyelid loading for treatment of exposure keratopathy secondary to non-cicatricial lagophthalmos. ( 27541938 )
2016
14
Comparison of Long-term Clinical Outcomes between Descemet's Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty in Patients with Bullous Keratopathy. ( 27980363 )
2016
15
Neurotrophic keratopathy secondary to trigeminal nerve aplasia in patient with Goldenhar syndrome. ( 26819096 )
2016
16
Corneal Collagen Cross Linking (CXL) in treatment of Pseudophakic Bullous Keratopathy. ( 27648049 )
2016
17
Five-Year PROSE Treatment for Aniridic Keratopathy. ( 27668496 )
2016
18
Pharmacologic Management of Pressure-Induced Stromal Keratopathy after LASIK. ( 27003814 )
2016
19
Keratopathy due to ophthalmic drug abuse with corneal melting and perforation presenting as Mooren-like ulcer: A case report. ( 27347060 )
2016
20
Infectious crystalline keratopathy caused by Cladosporium sp. after penetrating keratoplasty: a case report. ( 27621671 )
2016
21
The Hematologic Definition of Monoclonal Gammopathy of Undetermined Significance in Relation to Paraproteinemic Keratopathy (An American Ophthalmological Society Thesis). ( 28050052 )
2016
22
Superficial Keratectomy and Conjunctival Advancement Hood Flap (SKCAHF) for the Management of Bullous Keratopathy: Validation in Dogs With Spontaneous Disease. ( 27538190 )
2016
23
Paraproteinemic Keratopathy as the Presenting Sign of Hematologic Malignancy. ( 26872417 )
2016
24
Anterior segment optical coherence tomography of silicone oil keratopathy. ( 27558194 )
2016
25
Infectious crystalline keratopathy in dogs and cats: clinical, in vivo confocal microscopic, histopathologic, and microbiologic features of eight cases. ( 27352988 )
2016
26
Comparison of corneal degeneration and calcific band keratopathy from 2000 to 2013 in 69 horses. ( 26773714 )
2016
27
An association between systemic cyclosporine administration and development of acute bullous keratopathy in cats. ( 26880480 )
2016
28
Corneal Tattooing and Anterior Stromal Puncture for Treating Symptomatic Bullous Keratopathy. ( 26606297 )
2016
29
Elevated Cytokine Levels in the Aqueous Humor of Eyes With Bullous Keratopathy and Low Endothelial Cell Density. ( 27820951 )
2016
30
Risk of Band Keratopathy in Patients with End-Stage Renal Disease. ( 27346848 )
2016
31
LASIK Interface Complications: Pressure-induced Stromal Keratitis (PISK), Interface Fluid Syndrome (IFS) and Post-LASIK Edema-induced Keratopathy (PLEK). ( 27257731 )
2016
32
Dendritiform Keratopathy Associated with Exposure to Polyquarternium-1, a Common Ophthalmic Preservative. ( 26686962 )
2016
33
Optical coherence tomography of band keratopathy. ( 28039348 )
2016
34
Effects of diabetic keratopathy on corneal optical density, central corneal thickness, and corneal endothelial cell counts. ( 27588090 )
2016
35
Bilateral central toxic keratopathy after laser in situ keratomileusis. ( 26621902 )
2015
36
Long-term symptomatic relief of bullous keratopathy with amniotic membrane transplant. ( 25586624 )
2015
37
Prevalence of Punctate Keratopathy of West Indians in a Colombian Referral Center and a New Name Proposed: RiceA's Keratopathy. ( 25713637 )
2015
38
Climatic droplet keratopathy: an old disease in new clothes. ( 25626588 )
2015
39
The use of endoillumination probe-assisted Descemet membrane endothelial keratoplasty for bullous keratopathy secondary to argon laser iridotomy. ( 25609910 )
2015
40
Targeting growth factor supply in keratopathy treatment: comparison between maternal peripheral blood and cord blood as sources for the preparation of topical eye drops. ( 26192781 )
2015
41
Toxic keratopathy associated with abuse of topical anesthetics and amniotic membrane transplantation for treatment. ( 26558205 )
2015
42
Erlotinib-related keratopathy in a patient underwent laser in situ keratomileusis. ( 26264534 )
2015
43
Simultaneous Descemet's membrane endothelial keratoplasty and posterior iris-claw-fixated intra ocular lens implantation (IOL) in management of aphakic bullous keratopathy. ( 26286755 )
2015
44
Vortex Keratopathy: Fabry Related or Amiodarone Induced? ( 26153877 )
2015
45
Real-Time Microscope-Integrated OCT to Improve Visualization in DSAEK for Advanced Bullous Keratopathy. ( 26509766 )
2015
46
Incidence and risk factor evaluation of exposure keratopathy in critically ill patients: a cohort study. ( 25468364 )
2015
47
Climatic Droplet Keratopathy in Argentina: Involvement of Environmental Agents in Its Genesis Which Would Open the Prospect for New Therapeutic Interventions. ( 26451372 )
2015
48
Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model. ( 26509077 )
2015
49
Changes in Corneal Biomechanical Properties After Descemet Stripping Automated Endothelial Keratoplasty for Pseudophakic Bullous Keratopathy. ( 26555584 )
2015
50
Etiologies, Quantitative Hypoesthesia, and Clinical Outcomes of Neurotrophic Keratopathy. ( 25828513 )
2015

Variations for Keratopathy

Expression for Keratopathy

Search GEO for disease gene expression data for Keratopathy.

Pathways for Keratopathy

GO Terms for Keratopathy

Cellular components related to Keratopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 BMP4 FBN1 IGF1 IL1A NID1 TAC1
2 proteinaceous extracellular matrix GO:0005578 9.46 BMP4 FBN1 NID1 TNC
3 extracellular space GO:0005615 9.28 AKR1B1 BMP4 FBN1 IGF1 IL1A NID1
4 basement membrane GO:0005604 9.13 FBN1 NID1 TNC

Biological processes related to Keratopathy according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.89 AIRE BMP4 IGF1 IL1A PAX6
2 positive regulation of transcription, DNA-templated GO:0045893 9.86 AIRE BMP4 IGF1 PAX6
3 regulation of gene expression GO:0010468 9.72 BMP4 IGF1 PAX6
4 positive regulation of gene expression GO:0010628 9.67 BMP4 IL1A PAX6 TNC
5 skeletal system development GO:0001501 9.61 BMP4 FBN1 IGF1
6 positive regulation of protein secretion GO:0050714 9.58 IGF1 IL1A
7 negative regulation of extrinsic apoptotic signaling pathway GO:2001237 9.57 BMP4 IGF1
8 metanephros development GO:0001656 9.54 BMP4 FBN1
9 pituitary gland development GO:0021983 9.52 BMP4 PAX6
10 neuron fate commitment GO:0048663 9.51 BMP4 PAX6
11 positive regulation of mitotic nuclear division GO:0045840 9.48 IGF1 IL1A
12 renal system development GO:0072001 9.46 AKR1B1 BMP4
13 camera-type eye development GO:0043010 9.43 BMP4 FBN1 PAX6
14 positive regulation of ossification GO:0045778 9.4 BMP4 TAC1
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.33 AKR1B1 BMP4 IGF1
16 telencephalon regionalization GO:0021978 9.32 BMP4 PAX6
17 cellular protein metabolic process GO:0044267 9.26 BMP4 FBN1 IGF1 TNC
18 extracellular matrix organization GO:0030198 8.92 FBN1 NID1 TNC VCAM1

Molecular functions related to Keratopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 8.8 FBN1 IGF1 VCAM1

Sources for Keratopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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