Aliases & Classifications for Keratopathy

MalaCards integrated aliases for Keratopathy:

Name: Keratopathy 38 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2283
NCIt 47 C27012
UMLS 69 C0235270

Summaries for Keratopathy

MalaCards based summary : Keratopathy is related to bullous keratopathy and band keratopathy. An important gene associated with Keratopathy is PAX6 (Paired Box 6), and among its related pathways/superpathways are Degradation of the extracellular matrix and ECM-receptor interaction. The drugs Pharmaceutical Solutions and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and breast, and related phenotypes are no phenotypic analysis and normal

Related Diseases for Keratopathy

Diseases related to Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
id Related Disease Score Top Affiliating Genes
1 bullous keratopathy 12.3
2 band keratopathy 12.3
3 neurotrophic keratopathy 11.9
4 palmoplantar carcinoma, multiple self-healing 10.8
5 corneal dystrophy, schnyder type 10.8
6 clopidogrel resistance 10.4 AIRE NLRP1
7 endotheliitis 10.3
8 lacrimal duct obstruction 10.3 IGF1 PAX6
9 endometriosis of ovary 10.2 FBN1 TUBB3
10 aphthous stomatitis 10.2 PAX6 TUBB3
11 liver disease 10.2 KRT12 VCAM1
12 keratitis 10.1
13 oral mucosa leukoplakia 10.1 PAX6 TUBB3
14 polydactyly, postaxial, with progressive myopia 10.1 PAX6 TUBB3
15 aniridia 10.0
16 cataract 10.0
17 focal dystonia 10.0 NLRP1 VCAM1
18 lagophthalmos 9.9
19 acute allergic serous otitis media 9.9 FBN1 KRT12
20 keratoconus 9.9
21 multiple myeloma 9.9
22 anorectal stricture 9.9 AKR1B1 PAX6
23 fuchs' endothelial dystrophy 9.8
24 herpes zoster 9.8
25 alkaptonuria 9.8
26 histiocytic and dendritic cell cancer 9.7 IGF1 PAX6 VCAM1
27 idiopathic corneal edema 9.7 FBN1 NID1 TNC
28 citrullinemia, adult-onset type ii 9.7 AKR1B1 IGF1 VCAM1
29 corneal neovascularization 9.7
30 corneal disease 9.7
31 herpes simplex 9.7
32 strabismus 9.6
33 scleritis 9.6
34 amyloidosis 9.6
35 hyperparathyroidism 9.6
36 keratomalacia 9.6
37 lymphoma 9.6
38 choroiditis 9.6
39 insulin-like growth factor i 9.6
40 ptosis 9.6
41 corneal deposit 9.6
42 corneal ulcer 9.6
43 kawasaki disease 9.6
44 melanoma 9.6
45 fabry disease 9.6
46 xerophthalmia 9.6
47 astigmatism 9.6
48 myopia 9.6
49 mycobacterium abscessus 9.6
50 arthritis 9.6

Graphical network of the top 20 diseases related to Keratopathy:



Diseases related to Keratopathy

Symptoms & Phenotypes for Keratopathy

MGI Mouse Phenotypes related to Keratopathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.55 AIRE FBN1 KRT12 TNC VCAM1
2 normal MP:0002873 9.43 PAX6 TAC1 TNC AIRE IGF1 KRT12
3 renal/urinary system MP:0005367 9.02 AKR1B1 FBN1 IGF1 PAX6 TAC1

Drugs & Therapeutics for Keratopathy

Drugs for Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 88)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
2
Acetylcholine Approved Phase 2, Phase 3 51-84-3 187
3 abobotulinumtoxinA Phase 2, Phase 3
4 Botulinum Toxins Phase 2, Phase 3
5 Botulinum Toxins, Type A Phase 2, Phase 3
6 Cholinergic Agents Phase 2, Phase 3
7 Neuromuscular Agents Phase 2, Phase 3
8 Neurotransmitter Agents Phase 2, Phase 3
9 onabotulinumtoxinA Phase 2, Phase 3
10 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1
11 Ophthalmic Solutions Phase 3,Phase 1,Phase 2
12 Tetrahydrozoline Phase 3,Phase 1,Phase 2
13
Bevacizumab Approved, Investigational Phase 2 216974-75-3
14
Fluorometholone Approved Phase 2 426-13-1 9878
15
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
16
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
17
Ephedrine Approved Phase 1, Phase 2 299-42-3 9294
18
Pseudoephedrine Approved Phase 1, Phase 2 90-82-4 7028
19
Ambroxol Approved Phase 1, Phase 2 18683-91-5
20 Angiogenesis Inhibitors Phase 2
21 Angiogenesis Modulating Agents Phase 2
22 Antibodies Phase 2
23 Antibodies, Monoclonal Phase 2
24 Endothelial Growth Factors Phase 2
25 Immunoglobulins Phase 2
26 Mitogens Phase 2
27 Anesthetics Phase 2
28 Anti-Allergic Agents Phase 2
29 Antiemetics Phase 2
30 Anti-Inflammatory Agents Phase 2
31 Antineoplastic Agents, Hormonal Phase 2
32 Autonomic Agents Phase 2,Phase 1
33 Gastrointestinal Agents Phase 2
34 glucocorticoids Phase 2
35 Hormone Antagonists Phase 2
36 Hormones Phase 2
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
38 Methylprednisolone acetate Phase 2
39 Methylprednisolone Hemisuccinate Phase 2
40 Neuroprotective Agents Phase 2
41 Prednisolone acetate Phase 2
42 Prednisolone hemisuccinate Phase 2
43 Prednisolone phosphate Phase 2
44 Protective Agents Phase 2
45 Nasal Decongestants Phase 1, Phase 2
46 Respiratory System Agents Phase 1, Phase 2
47 Vasoconstrictor Agents Phase 1, Phase 2
48 Expectorants Phase 1, Phase 2
49 Anti-Bacterial Agents Phase 1, Phase 2
50 Anti-Infective Agents Phase 1, Phase 2

Interventional clinical trials:

(show all 38)

id Name Status NCT ID Phase Drugs
1 Study of the Presence and Extent of Corneal Disturbance Associated With B+L Biotrue MPS Used With B+L PureVision Lenses Completed NCT01268306 Phase 4
2 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
3 Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1 Recruiting NCT02600429 Phase 3 RGN-259;Placebo
4 Trial of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation Not yet recruiting NCT03248037 Phase 3 Netarsudil;Placebo
5 Stem Cells Treatment for Bilateral Limbic Associated Keratopathy (HULPOFT) Unknown status NCT01808378 Phase 2 Expanded adipose-derived stem cells
6 Bevacizumab for the Treatment of Corneal Neovascularization Unknown status NCT00992849 Phase 2 Bevacizumab
7 Amniotic Membrane Graft In Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
8 Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK) Completed NCT01448213 Phase 2 Prednisolone acetate;Fluorometholone
9 Utilization of Amniotic Membrane Extract Eye Drop (AMEED) on Human Corneal Healing Completed NCT02746848 Phase 1, Phase 2
10 Pain and Visual Outcome in Intravitreal Bevacizumab Injection Completed NCT02790775 Phase 2 Anti-VEGF in quadrant 1;Anti-VEGF in quadrant 2;Anti-VEGF in quadrant 3;Anti-VEGF in quadrant 4
11 Effects of Oral Mucolytics on Tear Film and Ocular Surface Completed NCT01713179 Phase 1, Phase 2 Ambroxol hydrochloride (Mucopect®, 60 mg, Boehringer Ingelheim)
12 A Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy Recruiting NCT03084861 Phase 1, Phase 2 Cord Blood Eye Drops;Conventional treatment
13 Study Evaluating Efficacy and Safety of SAR566658 Treatment in Patients With CA6 Positive Metastatic Triple Negative Breast Cancer Recruiting NCT02984683 Phase 2 SAR566658 (ACT14884)
14 Study of Ataluren in Patients With Aniridia Active, not recruiting NCT02647359 Phase 2 Ataluren;Placebo
15 A Randomized, Controlled, Double-Masked, Clinical Trial of Autologous Serum Eye Drops for Severe Ocular Chronic Graft-versus-Host Disease (GVHD) in Hematopoietic Stem Cell Transplant (HSCT) Patients Terminated NCT01972438 Phase 2 ASEDs;Saline
16 A Study of SAR428926 in Patients With Advanced Solid Tumors Recruiting NCT02575781 Phase 1 SAR428926
17 Assessment of Any Potential Retinal Effects of Tafenoquine (TQ) Active, not recruiting NCT02658435 Phase 1 Tafenoquine 150 mg;Matched placebo 150mg
18 Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media Unknown status NCT00623584
19 Comparing Endoglide to Endoserter for DSAEK Graft Insertion Unknown status NCT01791075
20 Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252 saline solution
21 Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT02020044
22 Amniotic Membrane and Anterior Stromal Puncture to the Treatment of Symptomatic Bullous Keratopathy Completed NCT00659308
23 The Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking on the Signs and Symptoms of Bullous Keratopathy Completed NCT01106274
24 Automated Lamellar Keratectomy in Symptomatic Patients With Bullous Keratopathy Completed NCT00654888 Mitomycin
25 The SNEC DSAEK EndoGlide Clinical Trial Completed NCT01122043
26 Eyelash Line Resection for Entropion Associated With Down's Syndrome Completed NCT01758718
27 A Comparison of Hydrogel Dressings and Ocular Lubricants in the Prevention on Corneal Damage in the Critically Ill Completed NCT00513734
28 Safety and Effectiveness of Subconjunctival Injection of Bevacizumab in the Treatment of Corneal Neovasculization Completed NCT00681603 subconjunctival injection of bevacizumab ( 1.25 to 2.50 mg)
29 Comparison of Patient Comfort After Two Anesthetic Protocols for Injections Into the Eye Completed NCT01087489 4% lidocaine;3.5% ophthalmic lidocaine gel
30 Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis Completed NCT00987467 Cyclosporin 0.05% ophthalmic;Cyclosporin 0.05% ophthalmic
31 Correlation of Gene Abnormalities and Clinical Manifestations of Aniridia Completed NCT00265590
32 Blood Based Eyedrops From Different Sources in the Treatment of Severe Keratopathy Recruiting NCT03064984
33 Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Recruiting NCT02660151 Salt solution
34 Staged and Combined Surgery for Cataract Patients With Corneal Endothelial Dysfunction Recruiting NCT02523950
35 Study of Endothelial Keratoplasty Outcomes Recruiting NCT00800111
36 Corneal Transplantation Guided by OCT RESCAN Not yet recruiting NCT02736877
37 Comparison of Aqueous and Plasma Glucose Level in Diabetic Patients Not yet recruiting NCT02750098
38 Topical Steroid Treatment After Posterior Lamellar Corneal Transplantation Withdrawn NCT01682421 Weak steroid (Flurolon, Allergan);Potent steroid (Maxidex, Alcon)

Search NIH Clinical Center for Keratopathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Keratopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Keratopathy:
Adipose-derived stem cells for treatment of bilateral limbic-associated keratopathy
Embryonic/Adult Cultured Cells Related to Keratopathy:
Adipose-derived stem cells

Genetic Tests for Keratopathy

Anatomical Context for Keratopathy

MalaCards organs/tissues related to Keratopathy:

39
Endothelial, Eye, Breast, Thyroid, T Cells, B Cells, Myeloid

Publications for Keratopathy

Articles related to Keratopathy:

(show top 50) (show all 748)
id Title Authors Year
1
Factors associated with surface epithelial keratopathy after optical penetrating keratoplasty. ( 28626820 )
2017
2
Neurotrophic Keratopathy: Therapeutic Approach Using a Novel Matrix Regenerating Agent. ( 28910175 )
2017
3
Asymptomatic Corneal Keratopathy Secondary toA Hypertyrosinaemia Following Low Dose Nitisinone andA aA Literature Review of Tyrosine Keratopathy inA Alkaptonuria. ( 28942493 )
2017
4
Infectious crystalline keratopathy after DescemetAca8-a8cs stripping endothelial keratoplasty. ( 28619977 )
2017
5
Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma. ( 28079685 )
2017
6
A rare case of concomitant sicca keratopathy and ipsilateral central facial palsy in Wallenberg's dorsolateral medullary syndrome. ( 28293537 )
2017
7
Clinical and morphological manifestations of aniridia-associated keratopathy on anterior segment optical coherence tomography and inA vivo confocal microscopy. ( 28698011 )
2017
8
A Case Series of Bee Sting Keratopathy With Different Outcomes in Malaysia. ( 28357167 )
2017
9
A case report of central toxic keratopathy in a patient post TransPRK (followed by corneal collagen cross-linking). ( 28450791 )
2017
10
Cow Urine Keratopathy: A Case Report. ( 28571179 )
2017
11
Corneal Neovascularization with Associated Lipid Keratopathy in a Patient with Obstructive Sleep Apnea-Hypopnea Syndrome Using a Continuous Positive Airway Pressure Machine. ( 28924439 )
2017
12
In vivo confocal microscopy of toxic keratopathy. ( 27740620 )
2017
13
Extensive bilateral corneal edema 6A weeks after cataract surgery: Keratopathy due to Asclepias physocarpa: a case report. ( 28100180 )
2017
14
Prevention of Exposure Keratopathy in Critically Ill Patients: A Single-Center, Randomized, Pilot Trial Comparing Ocular Lubrication With Bandage Contact Lenses and Punctal Plugs. ( 28820753 )
2017
15
Innovations in Treatment of Lagophthalmos and Exposure Keratopathy. ( 28885249 )
2017
16
Neurotrophic keratopathy in a patient with familial amyloidosis. ( 28602432 )
2017
17
Infectious Crystalline Keratopathy After Corneal Cross-linking. ( 28936055 )
2017
18
Analysis of corneal morphologic and pathologic changes in early-stage congenital aniridic keratopathy. ( 28393028 )
2017
19
In Vivo Confocal Microscopic Characteristics of Crystalline Keratopathy in Patients with Sclerokeratitis. ( 28282739 )
2017
20
Ocular exposure to paraquat resulting in keratopathy, pseudomembranous conjunctivitis and symblepharon. ( 28571054 )
2017
21
Nitisinone-Induced Keratopathy in Alkaptonuria: A Challenging Diagnosis Despite Clinical Suspicion. ( 28879639 )
2017
22
Phospholipidomic Studies in Human Cornea From Climatic Droplet Keratopathy. ( 28401586 )
2017
23
Glad Press'n Seal for the Treatment of Chronic Exposure Keratopathy. ( 28272173 )
2017
24
Paraproteinemic Keratopathy as the Presenting Sign of Hematologic Malignancy. ( 26872417 )
2016
25
Post-septal upper eyelid loading for treatment of exposure keratopathy secondary to non-cicatricial lagophthalmos. ( 27541938 )
2016
26
Descemet Stripping Automated Endothelial Keratoplasty in Fuchs' Endothelial Dystrophy versus Pseudophakic Bullous Keratopathy. ( 27994806 )
2016
27
Effects of diabetic keratopathy on corneal optical density, central corneal thickness, and corneal endothelial cell counts. ( 27588090 )
2016
28
Prosthetic Replacement of the Ocular Surface Ecosystem Scleral Lens Therapy for Exposure Keratopathy. ( 27171131 )
2016
29
LASIK Interface Complications: Pressure-induced Stromal Keratitis (PISK), Interface Fluid Syndrome (IFS) and Post-LASIK Edema-induced Keratopathy (PLEK). ( 27257731 )
2016
30
Pharmacologic Management of Pressure-Induced Stromal Keratopathy after LASIK. ( 27003814 )
2016
31
Refractory Tamoxifen-Induced Keratopathy Despite Drug Withdrawal. ( 27918356 )
2016
32
Risk of Band Keratopathy in Patients with End-Stage Renal Disease. ( 27346848 )
2016
33
Keratopathy due to ophthalmic drug abuse with corneal melting and perforation presenting as Mooren-like ulcer: A case report. ( 27347060 )
2016
34
Superficial Keratectomy and Conjunctival Advancement Hood Flap (SKCAHF) for the Management of Bullous Keratopathy: Validation in Dogs With Spontaneous Disease. ( 27538190 )
2016
35
Dendritiform Keratopathy Associated with Exposure to Polyquarternium-1, a Common Ophthalmic Preservative. ( 26686962 )
2016
36
Corneal Collagen Cross Linking (CXL) in treatment of Pseudophakic Bullous Keratopathy. ( 27648049 )
2016
37
Toxic Keratopathy Following the Use of Alcohol-Containing Antiseptics in Nonocular Surgery. ( 26913777 )
2016
38
Neurotrophic keratopathy secondary to trigeminal nerve aplasia in patient with Goldenhar syndrome. ( 26819096 )
2016
39
An association between systemic cyclosporine administration and development of acute bullous keratopathy in cats. ( 26880480 )
2016
40
Thymosin Beta 4: A Potential Novel Therapy for Neurotrophic Keratopathy, Dry Eye, and Ocular Surface Diseases. ( 27450739 )
2016
41
The Hematologic Definition of Monoclonal Gammopathy of Undetermined Significance in Relation to Paraproteinemic Keratopathy (An American Ophthalmological Society Thesis). ( 28050052 )
2016
42
Tegaderm(TM)dressing and Lacri-lube ointment moisture chamber to manage exposure keratopathy. ( 27769340 )
2016
43
Anterior segment optical coherence tomography of silicone oil keratopathy. ( 27558194 )
2016
44
Infectious crystalline keratopathy in dogs and cats: clinical, in vivo confocal microscopic, histopathologic, and microbiologic features of eight cases. ( 27352988 )
2016
45
The benefit of preventing exposure keratopathy in icu patient: a case report. ( 27217884 )
2016
46
Five-Year PROSE Treatment for Aniridic Keratopathy. ( 27668496 )
2016
47
Optical coherence tomography of band keratopathy. ( 28039348 )
2016
48
Corneal Tattooing and Anterior Stromal Puncture for Treating Symptomatic Bullous Keratopathy. ( 26606297 )
2016
49
Non-Descemet Stripping Automated Endothelial Keratoplasty for Bullous Keratopathy in Buphthalmic Eye. ( 27462256 )
2016
50
Infectious crystalline keratopathy caused by Cladosporium sp. after penetrating keratoplasty: a case report. ( 27621671 )
2016

Variations for Keratopathy

Expression for Keratopathy

Search GEO for disease gene expression data for Keratopathy.

Pathways for Keratopathy

GO Terms for Keratopathy

Cellular components related to Keratopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 AKR1B1 FBN1 IGF1 NID1 TAC1 TNC
2 basement membrane GO:0005604 9.13 FBN1 NID1 TNC

Biological processes related to Keratopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.13 FBN1 IGF1 TNC
2 extracellular matrix organization GO:0030198 8.92 FBN1 NID1 TNC VCAM1

Molecular functions related to Keratopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 8.8 FBN1 IGF1 VCAM1

Sources for Keratopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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