Aliases & Classifications for Keratopathy

MalaCards integrated aliases for Keratopathy:

Name: Keratopathy 37 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2283
NCIt 46 C27012
UMLS 69 C0235270

Summaries for Keratopathy

MalaCards based summary : Keratopathy is related to bullous keratopathy and corneal disease. An important gene associated with Keratopathy is PAX6 (Paired Box 6), and among its related pathways/superpathways are Degradation of the extracellular matrix and G-protein signaling_Rap2B regulation pathway. The drugs Pharmaceutical Solutions and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and breast, and related phenotypes are nervous system and normal

Related Diseases for Keratopathy

Diseases related to Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 bullous keratopathy 33.0 FBN1 NID1 TGFB2 TNC
2 corneal disease 29.5 KRT12 TGFB2 TUBB3
3 myopia 29.5 FBN1 PAX6 TGFB2
4 neurotrophic keratopathy 12.0
5 corneal dystrophy, band-shaped 11.7
6 schnyder corneal dystrophy 10.9
7 palmoplantar carcinoma, multiple self-healing 10.9
8 corneal degeneration, ribbonlike, with deafness 10.9
9 endotheliitis 10.4
10 stiff skin syndrome 10.3 FBN1 TGFB2
11 mononeuropathy 10.3 TAC1 TNC
12 autoimmune addison disease 10.3 AIRE NLRP1
13 vitreous disease 10.3 PAX6 TGFB2
14 keratitis, hereditary 10.2
15 exotropia 10.2 FBN1 TUBB3
16 pseudopapilledema 10.2 IGF1 PAX6
17 pathologic nystagmus 10.1 PAX6 TUBB3
18 juvenile glaucoma 10.1 PAX6 TGFB2
19 aniridia 1 10.1
20 loeys-dietz syndrome 10.1 FBN1 TGFB2
21 congenital ptosis 10.1 PAX6 TUBB3
22 cataract 10.1
23 congenital nystagmus 10.1 PAX6 TUBB3
24 poland syndrome 10.1 PAX6 TUBB3
25 aortic aneurysm, familial thoracic 1 10.0 FBN1 TGFB2
26 episodic pain syndrome, familial, 1 10.0
27 hydrops, lactic acidosis, and sideroblastic anemia 10.0
28 lagophthalmos 10.0
29 myeloma, multiple 10.0
30 keratoconus 10.0
31 streptococcal group a invasive disease 10.0
32 corneal dystrophy, fuchs endothelial, 1 9.9
33 fuchs' endothelial dystrophy 9.9
34 alkaptonuria 9.8
35 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8
36 herpes zoster 9.8
37 hypercalcemia, infantile, 1 9.8
38 arthritis 9.8
39 diabetes mellitus 9.8
40 corneal neovascularization 9.8
41 herpes simplex 9.8
42 rheumatoid arthritis 9.7
43 strabismus 9.7
44 leprosy 3 9.7
45 insulin-like growth factor i 9.7
46 fabry disease 9.7
47 astigmatism 9.7
48 kawasaki disease 9.7
49 crohn's disease 9.7
50 lymphoma 9.7

Graphical network of the top 20 diseases related to Keratopathy:



Diseases related to Keratopathy

Symptoms & Phenotypes for Keratopathy

MGI Mouse Phenotypes related to Keratopathy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.92 AIRE FBN1 IGF1 NID1 PAX6 TGFB2
2 normal MP:0002873 9.73 AIRE IGF1 KRT12 PAX6 TAC1 TNC
3 renal/urinary system MP:0005367 9.63 AKR1B1 FBN1 IGF1 PAX6 TAC1 TGFB2
4 respiratory system MP:0005388 9.43 AIRE FBN1 IGF1 PAX6 TGFB2 TUBB3
5 vision/eye MP:0005391 9.1 AIRE AKR1B1 KRT12 NID1 PAX6 TGFB2

Drugs & Therapeutics for Keratopathy

Drugs for Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 88)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
2
Acetylcholine Approved Phase 2, Phase 3 51-84-3 187
3 abobotulinumtoxinA Phase 2, Phase 3
4 Botulinum Toxins Phase 2, Phase 3
5 Botulinum Toxins, Type A Phase 2, Phase 3
6 Cholinergic Agents Phase 2, Phase 3
7 Neuromuscular Agents Phase 2, Phase 3
8 Neurotransmitter Agents Phase 2, Phase 3
9 onabotulinumtoxinA Phase 2, Phase 3
10 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1
11 Ophthalmic Solutions Phase 3,Phase 1,Phase 2
12 Tetrahydrozoline Phase 3,Phase 1,Phase 2
13
Bevacizumab Approved, Investigational Phase 2 216974-75-3
14
Fluorometholone Approved, Investigational Phase 2 426-13-1 9878
15
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
16
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
17
Ephedrine Approved Phase 1, Phase 2 299-42-3 9294
18
Pseudoephedrine Approved Phase 1, Phase 2 90-82-4 7028
19
Ambroxol Approved, Investigational Phase 1, Phase 2 18683-91-5
20 Angiogenesis Inhibitors Phase 2
21 Angiogenesis Modulating Agents Phase 2
22 Antibodies Phase 2
23 Antibodies, Monoclonal Phase 2
24 Endothelial Growth Factors Phase 2
25 Immunoglobulins Phase 2
26 Mitogens Phase 2
27 Anesthetics Phase 2
28 Anti-Allergic Agents Phase 2
29 Antiemetics Phase 2
30 Anti-Inflammatory Agents Phase 2
31 Antineoplastic Agents, Hormonal Phase 2
32 Autonomic Agents Phase 2,Phase 1
33 Gastrointestinal Agents Phase 2
34 glucocorticoids Phase 2
35 Hormone Antagonists Phase 2
36 Hormones Phase 2
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
38 Methylprednisolone acetate Phase 2
39 Methylprednisolone Hemisuccinate Phase 2
40 Neuroprotective Agents Phase 2
41 Prednisolone acetate Phase 2
42 Prednisolone hemisuccinate Phase 2
43 Prednisolone phosphate Phase 2
44 Protective Agents Phase 2
45 Nasal Decongestants Phase 1, Phase 2
46 Respiratory System Agents Phase 1, Phase 2
47 Vasoconstrictor Agents Phase 1, Phase 2
48 Expectorants Phase 1, Phase 2
49 Anti-Bacterial Agents Phase 1, Phase 2
50 Anti-Infective Agents Phase 1, Phase 2

Interventional clinical trials:

(show all 41)

# Name Status NCT ID Phase Drugs
1 Study of the Presence and Extent of Corneal Disturbance Associated With B+L Biotrue MPS Used With B+L PureVision Lenses Completed NCT01268306 Phase 4
2 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
3 Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1 Recruiting NCT02600429 Phase 3 RGN-259;Placebo
4 Trial of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation Recruiting NCT03248037 Phase 3 Netarsudil;Placebo
5 Stem Cells Treatment for Bilateral Limbic Associated Keratopathy (HULPOFT) Unknown status NCT01808378 Phase 2 Expanded adipose-derived stem cells
6 Bevacizumab for the Treatment of Corneal Neovascularization Unknown status NCT00992849 Phase 2 Bevacizumab
7 Amniotic Membrane Graft In Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
8 Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK) Completed NCT01448213 Phase 2 Prednisolone acetate;Fluorometholone
9 Utilization of Amniotic Membrane Extract Eye Drop (AMEED) on Human Corneal Healing Completed NCT02746848 Phase 1, Phase 2
10 Pain and Visual Outcome in Intravitreal Bevacizumab Injection Completed NCT02790775 Phase 2 Anti-VEGF in quadrant 1;Anti-VEGF in quadrant 2;Anti-VEGF in quadrant 3;Anti-VEGF in quadrant 4
11 Effects of Oral Mucolytics on Tear Film and Ocular Surface Completed NCT01713179 Phase 1, Phase 2 Ambroxol hydrochloride (Mucopect®, 60 mg, Boehringer Ingelheim)
12 A Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy Recruiting NCT03084861 Phase 1, Phase 2 Cord Blood Eye Drops;Conventional treatment
13 Study Evaluating Efficacy and Safety of SAR566658 Treatment in Patients With CA6 Positive Metastatic Triple Negative Breast Cancer Recruiting NCT02984683 Phase 2 SAR566658 (ACT14884)
14 Study of Ataluren in Patients With Aniridia Active, not recruiting NCT02647359 Phase 2 Ataluren;Placebo
15 A Randomized, Controlled, Double-Masked, Clinical Trial of Autologous Serum Eye Drops for Severe Ocular Chronic Graft-versus-Host Disease (GVHD) in Hematopoietic Stem Cell Transplant (HSCT) Patients Terminated NCT01972438 Phase 2 ASEDs;Saline
16 Assessment of Any Potential Retinal Effects of Tafenoquine (TQ) Completed NCT02658435 Phase 1 Tafenoquine 150 mg;Matched placebo 150mg
17 A Study of SAR428926 in Patients With Advanced Solid Tumors Active, not recruiting NCT02575781 Phase 1 SAR428926
18 Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media Unknown status NCT00623584
19 Comparing Endoglide to Endoserter for DSAEK Graft Insertion Unknown status NCT01791075
20 Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252 saline solution
21 Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT02020044
22 Long Term Results of Amniotic Membrane Transplant in Bullous Keratopathy Patients Completed NCT03450954
23 Amniotic Membrane and Anterior Stromal Puncture to the Treatment of Symptomatic Bullous Keratopathy Completed NCT00659308
24 The Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking on the Signs and Symptoms of Bullous Keratopathy Completed NCT01106274
25 Automated Lamellar Keratectomy in Symptomatic Patients With Bullous Keratopathy Completed NCT00654888 Mitomycin
26 The SNEC DSAEK EndoGlide Clinical Trial Completed NCT01122043
27 Eyelash Line Resection for Entropion Associated With Down's Syndrome Completed NCT01758718
28 A Comparison of Hydrogel Dressings and Ocular Lubricants in the Prevention on Corneal Damage in the Critically Ill Completed NCT00513734
29 Safety and Effectiveness of Subconjunctival Injection of Bevacizumab in the Treatment of Corneal Neovasculization Completed NCT00681603 subconjunctival injection of bevacizumab ( 1.25 to 2.50 mg)
30 Comparison of Patient Comfort After Two Anesthetic Protocols for Injections Into the Eye Completed NCT01087489 4% lidocaine;3.5% ophthalmic lidocaine gel
31 Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis Completed NCT00987467 Cyclosporin 0.05% ophthalmic;Cyclosporin 0.05% ophthalmic
32 Correlation of Gene Abnormalities and Clinical Manifestations of Aniridia Completed NCT00265590
33 Blood Based Eyedrops From Different Sources in the Treatment of Severe Keratopathy Recruiting NCT03064984
34 Visual Quality and Contrast Sensitivity Function After Corneal Transplantation Recruiting NCT03447041
35 Air Versus SF6 for Descemet's Membrane Endothelial Keratoplasty (DMEK) Recruiting NCT03407755
36 Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Recruiting NCT02660151 Salt solution
37 Staged and Combined Surgery for Cataract Patients With Corneal Endothelial Dysfunction Recruiting NCT02523950
38 Study of Endothelial Keratoplasty Outcomes Recruiting NCT00800111
39 Corneal Transplantation Guided by OCT RESCAN Not yet recruiting NCT02736877
40 Comparison of Aqueous and Plasma Glucose Level in Diabetic Patients Not yet recruiting NCT02750098
41 Topical Steroid Treatment After Posterior Lamellar Corneal Transplantation Withdrawn NCT01682421 Weak steroid (Flurolon, Allergan);Potent steroid (Maxidex, Alcon)

Search NIH Clinical Center for Keratopathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Keratopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Keratopathy:
Adipose-derived stem cells for treatment of bilateral limbic-associated keratopathy
Embryonic/Adult Cultured Cells Related to Keratopathy:
Adipose-derived stem cells

Genetic Tests for Keratopathy

Anatomical Context for Keratopathy

MalaCards organs/tissues related to Keratopathy:

38
Endothelial, Eye, Breast, Thyroid, T Cells, B Cells, Myeloid

Publications for Keratopathy

Articles related to Keratopathy:

(show top 50) (show all 768)
# Title Authors Year
1
Incidence, risk factors and impact of protocolised care on exposure keratopathy in critically ill adults: a two-phase prospective cohort study. ( 29338772 )
2018
2
Corneal Neurotization for Neurotrophic Keratopathy: Clinical Outcomes and In Vivo Confocal Microscopic and Histopathological Findings. ( 29373338 )
2018
3
Pigmentary keratopathy in a child: Histopathologic analysis. ( 29370944 )
2018
4
Corneal Abnormalities in Congenital Aniridia: Congenital Central Corneal Opacity Versus Aniridia-associated Keratopathy. ( 29101006 )
2018
5
Stage-related central corneal epithelial transformation in congenital aniridia-associated keratopathy. ( 29133179 )
2018
6
EDTA chelation for symptomatic band keratopathy: results and recurrence. ( 29192681 )
2018
7
The Impact of Normal Saline on the Incidence of Exposure Keratopathy in Patients Hospitalized in Intensive Care Units. ( 29344048 )
2018
8
Dry eye and meibomian gland dysfunction in pseudophakic bullous keratopathy. ( 29392636 )
2018
9
Topical ganciclovir treatment post-Descemet's stripping automated endothelial keratoplasty for patients with bullous keratopathy induced by cytomegalovirus. ( 29363530 )
2018
10
In Vivo Confocal Microscopy Reveals Corneal Reinnervation After Treatment of Neurotrophic Keratopathy With Corneal Neurotization. ( 29053558 )
2018
11
Neurotrophic Keratopathy: Therapeutic Approach Using a Novel Matrix Regenerating Agent. ( 28910175 )
2017
12
Clinical and morphological manifestations of aniridia-associated keratopathy on anterior segment optical coherence tomography and inA vivo confocal microscopy. ( 28698011 )
2017
13
Regulatory Compliant Tissue-Engineered Human Corneal Endothelial Grafts Restore Corneal Function of Rabbits with Bullous Keratopathy. ( 29074873 )
2017
14
Pseudophakic bullous keratopathy. ( 29450379 )
2017
15
Unusual Course of Crystalline Keratopathy in a Patient with Graft-Versus-Host Disease. ( 29326852 )
2017
16
Corneal perforation from peripheral ulcerative keratopathy in patients with rheumatoid arthritis: epidemiological findings of the British Ophthalmological Surveillance Unit. ( 29246891 )
2017
17
Glad Press'n Seal for the Treatment of Chronic Exposure Keratopathy. ( 28272173 )
2017
18
Asymptomatic Corneal Keratopathy Secondary toA Hypertyrosinaemia Following Low Dose Nitisinone andA aA Literature Review of Tyrosine Keratopathy inA Alkaptonuria. ( 28942493 )
2017
19
Cow Urine Keratopathy: A Case Report. ( 28571179 )
2017
20
Infectious crystalline keratopathy after DescemetAca8-a8cs stripping endothelial keratoplasty. ( 28619977 )
2017
21
Innovations in Treatment of Lagophthalmos and Exposure Keratopathy. ( 28885249 )
2017
22
Factors associated with surface epithelial keratopathy after optical penetrating keratoplasty. ( 28626820 )
2017
23
In vivo confocal microscopy of toxic keratopathy. ( 27740620 )
2017
24
Infectious Crystalline Keratopathy After Corneal Cross-linking. ( 28936055 )
2017
25
A case report of central toxic keratopathy in a patient post TransPRK (followed by corneal collagen cross-linking). ( 28450791 )
2017
26
Paraproteinemic keratopathy in monoclonal gammopathy of undetermined significance treated with primary keratoprosthesis: Case report, histopathologic findings, and world literature review. ( 29390260 )
2017
27
Infectious crystalline keratopathy. ( 29097211 )
2017
28
Effect of Scattering and Aberrations on Visual Acuity for Band Keratopathy. ( 29035922 )
2017
29
In Vivo Confocal Microscopic Characteristics of Crystalline Keratopathy in Patients with Sclerokeratitis. ( 28282739 )
2017
30
Exposure keratopathy: Incidence, risk factors and impact of protocolised care on exposure keratopathy in critically ill adults. ( 29353117 )
2017
31
Analysis of corneal morphologic and pathologic changes in early-stage congenital aniridic keratopathy. ( 28393028 )
2017
32
Corneal Neovascularization with Associated Lipid Keratopathy in a Patient with Obstructive Sleep Apnea-Hypopnea Syndrome Using a Continuous Positive Airway Pressure Machine. ( 28924439 )
2017
33
Phospholipidomic Studies in Human Cornea From Climatic Droplet Keratopathy. ( 28401586 )
2017
34
Prevention of Exposure Keratopathy in Critically Ill Patients: A Single-Center, Randomized, Pilot Trial Comparing Ocular Lubrication With Bandage Contact Lenses and Punctal Plugs. ( 28820753 )
2017
35
Young donor-graft assisted endothelial keratoplasty (PDEK/DMEK) with epithelial debridement for chronic pseudophakic bullous keratopathy. ( 28985815 )
2017
36
A Case Series of Bee Sting Keratopathy With Different Outcomes in Malaysia. ( 28357167 )
2017
37
Ocular exposure to paraquat resulting in keratopathy, pseudomembranous conjunctivitis and symblepharon. ( 28571054 )
2017
38
Extensive bilateral corneal edema 6A weeks after cataract surgery: Keratopathy due to Asclepias physocarpa: a case report. ( 28100180 )
2017
39
Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma. ( 28079685 )
2017
40
Nitisinone-Induced Keratopathy in Alkaptonuria: A Challenging Diagnosis Despite Clinical Suspicion. ( 28879639 )
2017
41
A rare case of concomitant sicca keratopathy and ipsilateral central facial palsy in Wallenberg's dorsolateral medullary syndrome. ( 28293537 )
2017
42
Neurotrophic keratopathy in a patient with familial amyloidosis. ( 28602432 )
2017
43
Five-Year PROSE Treatment for Aniridic Keratopathy. ( 27668496 )
2016
44
Toxic Keratopathy Following the Use of Alcohol-Containing Antiseptics in Nonocular Surgery. ( 26913777 )
2016
45
Neurotrophic keratopathy secondary to trigeminal nerve aplasia in patient with Goldenhar syndrome. ( 26819096 )
2016
46
Keratopathy due to ophthalmic drug abuse with corneal melting and perforation presenting as Mooren-like ulcer: A case report. ( 27347060 )
2016
47
Corneal Tattooing and Anterior Stromal Puncture for Treating Symptomatic Bullous Keratopathy. ( 26606297 )
2016
48
Comparison of Long-term Clinical Outcomes between Descemet's Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty in Patients with Bullous Keratopathy. ( 27980363 )
2016
49
Optical coherence tomography of band keratopathy. ( 28039348 )
2016
50
Anterior segment optical coherence tomography of silicone oil keratopathy. ( 27558194 )
2016

Variations for Keratopathy

Expression for Keratopathy

Search GEO for disease gene expression data for Keratopathy.

Pathways for Keratopathy

Pathways related to Keratopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.58 FBN1 NID1 TGFB2 TNC
2 10.16 FBN1 IGF1 TGFB2 TNC

GO Terms for Keratopathy

Cellular components related to Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.46 FBN1 NID1 TGFB2 TNC
2 extracellular space GO:0005615 9.17 AKR1B1 FBN1 IGF1 NID1 TAC1 TGFB2
3 basement membrane GO:0005604 9.13 FBN1 NID1 TNC

Biological processes related to Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.61 FBN1 IGF1 TNC
2 extracellular matrix organization GO:0030198 9.54 FBN1 NID1 TNC
3 positive regulation of protein secretion GO:0050714 9.46 IGF1 TGFB2
4 skeletal system development GO:0001501 9.43 FBN1 IGF1 TGFB2
5 positive regulation of epithelial cell migration GO:0010634 9.4 TAC1 TGFB2
6 eye development GO:0001654 9.32 PAX6 TGFB2
7 positive regulation of ossification GO:0045778 9.16 TAC1 TGFB2
8 salivary gland morphogenesis GO:0007435 8.96 PAX6 TGFB2
9 response to wounding GO:0009611 8.8 PAX6 TGFB2 TNC

Sources for Keratopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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