MCID: KRT008
MIFTS: 52

Keratopathy malady

Summaries for Keratopathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Keratopathy can refer to: more...

MalaCards: Keratopathy is related to bullous keratopathy and band keratopathy. An important gene associated with Keratopathy is SOD3 (superoxide dismutase 3, extracellular), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Platelet degranulation . The compounds estrogen and ly303870 have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and testes, and related mouse phenotypes are respiratory system and craniofacial.

Aliases & Classifications for Keratopathy

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8Disease Ontology, 10DISEASES, 30LifeMap Discovery™, 60UMLS, 39NCIt
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Aliases & Descriptions:

keratopathy 8 10 30 60


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Disease Ontology8 DOID:2283
NCIt39 C27012

Related Diseases for Keratopathy

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17GeneCards, 18GeneDecks
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Diseases related to Keratopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1bullous keratopathy31.5SOD3, TNC, TGFB2, IL1A, DCN, FBN1
2band keratopathy31.1GLYR1, SLC4A4
3cataract30.5SLC4A4, TGFB3, TGFB2
4glaucoma30.5FBN1, SLC4A4, AQP1, TGFB2
5keratoconus30.3COL8A2, SOD3, TNC, KERA, DCN
6fuchs' endothelial dystrophy30.3AQP1, COL8A2
7corneal disease30.3IL1A, TGFB2
8corneal dystrophy30.1COL8A2
9diabetes mellitus30.1TAC1
10corneal edema30.1PBK
11arthritis30.0SOD3, FBN1, IL1A, TAC1
12melanoma29.9PDGFB, TNC, DCN, IL1A, TGFB3, TGFB2
13pneumonia29.7TGFB2, SOD3
14rheumatoid arthritis29.7SOD3, DCN, IL1A, TAC1
15atherosclerosis29.7SOD3, PDGFB, FBN1, DCN, IL1A
16dermatitis29.7TAC1, IL1A
17sarcoidosis29.7PDGFB, DCN, IL1A, TAC1, TGFB2
18keratitis10.4
19aniridia10.4
20lagophthalmos10.3
21myeloma10.3
22multiple myeloma10.2
23corneal ulcer10.1
24hypercalcemia10.1
25limbal stem cell deficiency10.0
26crohn's disease10.0
27xerophthalmia10.0
28keratomalacia10.0
29cystinosis10.0
30herpes zoster10.0
31fabry disease10.0
32astigmatism10.0
33corneal deposit10.0
34corneal neovascularization10.0
35herpes simplex10.0
36hyperparathyroidism10.0
37leprosy10.0
38myopia10.0
39scleritis10.0
40strabismus10.0
41uveitis10.0
42neurotrophic keratopathy10.0
43aortic aneurysm10.0FBN1
44primary open angle glaucoma10.0TGFB2
45dilated cardiomyopathy10.0FBN1
46peritonitis10.0AQP1
47gingivitis10.0IL1A
48pancreatitis10.0TAC1
49hypertension10.0TAC1
50hepatitis10.0PDGFB

Graphical network of the top 20 diseases related to Keratopathy:



Diseases related to keratopathy

Clinical Features for Keratopathy

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Drugs & Therapeutics for Keratopathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Keratopathy

Drug clinical trials:

Search ClinicalTrials for Keratopathy

Search NIH Clinical Center for Keratopathy

Search CenterWatch for Keratopathy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Keratopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Keratopathy:
Adipose-derived stem cells for treatment of bilateral limbic-associated keratopathy
Embryonic/Adult Cultured Cells Related to Keratopathy:
Adipose-derived stem cells

Genetic Tests for Keratopathy

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Anatomical Context for Keratopathy

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32MalaCards
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MalaCards organs/tissues related to Keratopathy:

32
Endothelial, Eye, Testes, Skin, Brain, Lung, B cells

Animal Models for Keratopathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Keratopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.1DCN, AQP1, TGFB3, TGFB2, ITGB6
2MP:000538210.0TGFB3, AQP3, SLC4A4, FBN1, TGFB2, DCN
3MP:00053679.9AQP1, PDGFB, FBN1, DCN, TGFB2, AQP3
4MP:00053919.9COL8A2, KERA, DCN, SLC4A4, AQP3, AQP1
5MP:00053859.7IL1A, AQP3, TGFB3, SLC4A4, TAC1, AQP1
6MP:00053879.7SLC4A4, SOD3, PDGFB, TGFB2, AQP9, AQP3
7MP:00107719.6PDGFB, ITGB6, DCN, TAC1, SLC4A4, FBN1
8MP:00053979.6KERA, FBN1, PDGFB, ITGB6, DCN, IL1A
9MP:00053769.6AQP1, AQP3, SLC4A4, TGFB3, TNC, TGFB2

Publications for Keratopathy

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50PubMed
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Articles related to Keratopathy:

(show top 50)    (show all 630)
idTitleAuthorsYear
1
Midinfrared Laser Pancorneal Coagulation as a Method of Treatment for Painful Bullous Keratopathy. (23974894)
2013
2
Autologous tragal perichondrium transplantation: a novel approach for the management of painful bullous keratopathy. (23730105)
2013
3
Confocal microscopy in a case of crystalline keratopathy in a patient with smouldering multiple myeloma. (23928943)
2013
4
A red eye on the intensive care unit. Exposure keratopathy with corneal abrasion secondary to lagophthalmos due to chemosis. (23723116)
2013
5
Punctate keratopathy of West Indians in patients undergoing photorefractive surgery. (23355587)
2013
6
Bullous keratopathy as a progressive disease: evidence from clinical and laboratory imaging studies. (24104939)
2013
7
Infectious Crystalline Keratopathy Caused by Pseudomonas fluorescens. (24113463)
2013
8
Anesthetic keratopathy presenting as bilateral Mooren-like ulcers. (23118524)
2012
9
Abnormalities of stromal structure in the bullous keratopathy cornea identified by second harmonic generation imaging microscopy. (22736613)
2012
10
Keratopathy: white patches, clear dots and grey lines. (20829313)
2012
11
The effects of riboflavin/ultraviolet: a corneal cross-linking on the signs and symptoms of bullous keratopathy. (21572736)
2011
12
The expression of interleukin-1 alpha, TNF and VEGF in corneal cells of patients with bullous keratopathy. (22220428)
2011
13
Immunotactoid microtubular corneal deposits in bilateral paraprotein crystalline keratopathy and atypical corneal immunoglobulin deposition in a patient with dysproteinemia. (21099423)
2011
14
Combined ethylenediaminetetraacetic acid chelation, phototherapeutic keratectomy and amniotic membrane transplantation for treatment of band keratopathy. (20379455)
2010
15
Comparative evaluation of phototherapeutic keratectomy and amniotic membrane transplantation for management of symptomatic chronic bullous keratopathy. (20517149)
2010
16
Development of crystalline keratopathy after intravitreal injections of pegaptanib. (20508650)
2010
17
In vivo morphometry of corneal endothelial cells in pseudoexfoliation keratopathy with glaucoma and cataract. (19365152)
2009
18
Randomised trial comparing ocular lubricants and polyacrylamide hydrogel dressings in the prevention of exposure keratopathy in the critically ill. (18810388)
2009
19
Long-term topical steroid treatment after penetrating keratoplasty in patients with pseudophakic bullous keratopathy. (19815284)
2009
20
Chronic wound state exacerbated by oxidative stress in Pax6+/- aniridia-related keratopathy. (18491289)
2008
21
Ahram mineral water-induced sulfate keratopathy: histopathologic, electron microscopic, and confocal scan features. (18812763)
2008
22
Neuroparalytic keratopathy as the first sign of a cerebral meningioma. (17894293)
2007
23
Infectious crystalline keratopathy caused by Gemella haemolysans. (17525671)
2007
24
Climatic droplet keratopathy in the Argentine Patagonia. (16564815)
2006
25
Hypopyon uveitis following band keratopathy removal in ankylosing spondylitis-a case report. (16507493)
2006
26
Detection of Streptococcus species by polymerase chain reaction in infectious crystalline keratopathy. (17172904)
2006
27
Efficacy of two chondroitin sulfate ophthalmic solutions in the therapy of spontaneous chronic corneal epithelial defects and ulcerative keratitis associated with bullous keratopathy in dogs. (16497231)
2006
28
Neurotrophic keratopathy and diabetes mellitus. (16215544)
2006
29
Post-LASIK infectious crystalline keratopathy caused by Alternaria. (16227855)
2005
30
Evolving concepts on the pathogenic mechanisms of aniridia related keratopathy. (15618012)
2005
31
Recurrence of giant pseudocyst in advanced bullous keratopathy. (14976545)
2004
32
Management of band keratopathy with excimer phototherapeutic keratectomy: visual, refractive, and symptomatic outcome. (12640412)
2003
33
Infectious crystalline keratopathy in an immunosuppressed patient. (11352447)
2001
34
Infectious keratitis in climatic droplet keratopathy. (10928756)
2000
35
Delayed mustard gas keratopathy: clinical findings and confocal microscopy. (10577594)
1999
36
Topical diclofenac sodium in the management of anesthetic abuse keratopathy. (9625565)
1998
37
Ulcerative keratitis in bullous keratopathy. (9160028)
1997
38
Phototherapeutic keratectomy for climatic droplet keratopathy, KKESH Excimer Laser Study Group. King Khaled Eye Specialist Hospital. (8963799)
1996
39
Successful phototherapeutic keratectomy for recurrent erosions in bullous keratopathy. (8653513)
1996
40
Extracellular matrix alterations in human corneas with bullous keratopathy. (8631643)
1996
41
Detection of mRNA for the cytokines, interleukin-1 alpha and interleukin-8, in corneas from patients with pseudophakic bullous keratopathy. (7657553)
1995
42
Climatic droplet keratopathy. (7936561)
1994
43
Pseudophakic bullous keratopathy in Switzerland. (2776944)
1989
44
Atypical band keratopathy following long-term pilocarpine treatment. (2713309)
1989
45
The incidence of preoperative endothelial dystrophy in pseudophakic bullous keratopathy. (3277104)
1988
46
Intraocular lens removal during penetrating keratoplasty for pseudophakic bullous keratopathy. (3323988)
1987
47
Cytochrome oxidase activity of postsurgical bullous keratopathy endothelium. (2822357)
1987
48
Bullous keratopathy: a perspective on the American experience. (6478579)
1984
49
Clinical observations on the treatment of bullous keratopathy. (13556833)
1957-1958
50
Band keratopathy in vitamin D intoxication; report of a case. (13170871)
1954

Genetic Variations for Keratopathy

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Expression for genes affiliated with Keratopathy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratopathy

Search GEO for disease gene expression data for Keratopathy.

Pathways for genes affiliated with Keratopathy

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Sources:
52R&D Systems, 53Reactome, 51QIAGEN, 29KEGG, 4Cell Signaling Technology, 55SinoBiological, 37NCBI BioSystems Database
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Pathways related to Keratopathy according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.4TGFB3
2
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10.4TGFB3
3
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10.3TGFB2, TGFB3
4
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10.3TGFB3, TGFB2
5
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10.3TGFB2, TGFB3
6
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10.3TGFB2, TGFB3
710.3TGFB2, TGFB3
8
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10.3TGFB2, TGFB3
910.3TGFB2, TGFB3
1010.3TGFB2, TGFB3, TNC
1110.2DCN, TGFB3, TGFB2
1210.2TGFB2, TGFB3, DCN
13
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10.2TGFB2, TGFB3, ITGB6
1410.2SLC4A4, AQP1, AQP9
1510.2AQP1, AQP3, AQP9
16
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10.2PDGFB, IL1A, TGFB3, TGFB2
17
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10.2TGFB2, TGFB3, IL1A, PDGFB
18
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10.1TGFB2, TGFB3, FBN1, ITGB6
19
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10.1PDGFB, TNC, ITGB6, PTK6
20
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10.1PDGFB, ITGB6, IL1A, TGFB3, TGFB2
21
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10.1PDGFB, ITGB6, IL1A, TGFB3, TGFB2
22
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10.0COL8A2, PDGFB, TNC, ITGB6, FBN1, DCN
23
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10.0TGFB3, DCN, FBN1, ITGB6, TNC, PDGFB
24
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9.9PDGFB, AQP1, AQP3, AQP9, TGFB3, TGFB2
25
Hide members
9.9COL8A2, PDGFB, TNC, ITGB6, FBN1, TGFB3
26
Hide members
9.8COL8A2, PDGFB, TNC, ITGB6, FBN1, IL1A

Compounds for genes affiliated with Keratopathy

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Keratopathy according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8TAC1
2ly30387044 2811.7TAC1, CD160
3physalaemin44 2811.6CD160, TAC1
4forskolin44 49 1112.6TAC1, AQP3
5alginate4410.6DCN, TGFB3, TGFB2
6hg2+2810.6AQP9, AQP3, AQP1
7sr489684410.6CD160, TAC1
8mercury4410.6AQP3, AQP1, AQP9
9eledoisin44 2811.6CD160, TAC1
10pcmbs4410.6AQP1, AQP3
11silver4410.6TNC, PDGFB, AQP3, AQP1
12septide44 2811.6TAC1, CD160
13heparan sulfate44 2411.6FBN1, DCN, SOD3, TNC
14glycosaminoglycan4410.6TGFB3, IL1A, TGFB2, DCN, TNC
15hyaluronic acid44 2411.6IL1A, TNC, TGFB2, FBN1, DCN
16hgcl24410.6AQP1, AQP3
17senktide44 59 2812.5CD160, TAC1
18sodium dodecylsulfate4410.5FBN1, DCN, IL1A, TAC1
19vitamin d4410.5TGFB2, SOD3
20ascorbic acid44 2411.5TGFB2, TNC, IL1A, FBN1, SOD3
21serine4410.5IL1A, FBN1, PDGFB, SOD3
22heparin44 28 11 2413.5TAC1, IL1A, DCN, FBN1, SOD3
23urea44 11 2412.5AQP9, AQP3, AQP1, SOD3
24creatinine4410.5DCN, TGFB2, AQP3, IL1A, AQP1
25chondroitin sulfate44 2411.5DCN, FBN1, TNC
26ribonucleic acid4410.5TGFB2, IL1A, PDGFB, DCN, TGFB3
27cyclosporin a44 28 5912.5TGFB2, PDGFB, DCN, CD160
28tgf beta14410.5TGFB3, DCN, FBN1, TNC, PDGFB, TGFB2
29mepyramine44 1111.4IL1A, TAC1
30chloride4410.4SLC4A4, TAC1, AQP3, AQP1
31paraffin4410.4DCN, TNC, PDGFB, TGFB3, TGFB2, AQP1
32progesterone44 59 28 11 2414.4TGFB3, PDGFB, IL1A, TNC, FBN1, TGFB2
33acetazolamide44 1111.4AQP1, SLC4A4
34neurocan4410.3DCN, TNC
35retinoic acid44 2411.3TNC, DCN, TGFB2, TGFB3, FBN1, IL1A
36glucose4410.3AQP1, TGFB2, AQP9, AQP3
37oligonucleotide4410.3PDGFB, TNC, AQP1, TGFB2, TGFB3, DCN
38dexamethasone44 49 28 1113.3AQP1, TGFB2, TGFB3, AQP3, TAC1, DCN
39arginine4410.3TAC1, DCN, FBN1, SOD3, AQP1, IL1A
40acetylcholine44 49 28 11 2414.3SOD3, IL1A, TAC1, CD160
41vegf4410.3SOD3, PDGFB, TNC, DCN, IL1A, AQP1
42cysteine4410.3SOD3, TNC, FBN1, DCN, TAC1, AQP1
43glutamate4410.3TAC1, TNC, SLC4A4, TGFB2, DCN, IL1A
44nitric oxide44 11 2412.3TAC1, TGFB3, AQP1, TGFB2, IL1A, PDGFB
45lipid4410.2TNC, PDGFB, FBN1, AQP1, TAC1, TGFB3
46mannitol44 1111.2AQP9, AQP1, AQP3
47steroid4410.2TGFB2, DCN, TAC1, TGFB3, AQP1
48sodium nitroprusside4410.1TAC1, SOD3, AQP1
49tyrosine4410.1PDGFB, TNC, SLC4A4, PTK6, TAC1, TGFB3
50polyglycolic acid4410.0TGFB3, PDGFB

GO Terms for genes affiliated with Keratopathy

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16Gene Ontology
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Cellular components related to Keratopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:00560410.3FBN1, TNC, COL8A2
2extracellular matrixGO:03101210.1TGFB3, COL8A2, SOD3, TNC, FBN1, DCN
3platelet alpha granule lumenGO:0310939.9TGFB2, TGFB3, PDGFB
4basolateral plasma membraneGO:0163239.9AQP1, AQP3, PDGFB, AQP9, SLC4A4
5extracellular spaceGO:0056159.8TGFB2, TGFB3, TAC1, FBN1, DCN, TNC
6extracellular regionGO:0055769.7TGFB2, TNC, IL1A, DCN, FBN1, KERA

Biological processes related to Keratopathy according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1menstrual cycle phaseGO:02260110.6TGFB2, TGFB3
2negative regulation of macrophage cytokine productionGO:01093610.6TGFB2, TGFB3
3positive regulation of saliva secretionGO:04687810.5TAC1, AQP1
4glycerol transportGO:01579310.5AQP1, AQP9
5water transportGO:00683310.5AQP1, AQP9, AQP3
6salivary gland morphogenesisGO:00743510.5TGFB3, TGFB2
7positive regulation of cell divisionGO:05178110.5PDGFB, TGFB2, TGFB3, IL1A
8odontogenesisGO:04247610.5TGFB3, AQP3, AQP1, TGFB2
9response to hypoxiaGO:00166610.4TGFB2, SOD3, TGFB3, PDGFB
10SMAD protein import into nucleusGO:00718410.4TGFB2, TGFB3
11cell growthGO:01604910.4TGFB2, TGFB3, PDGFB
12response to woundingGO:00961110.4TGFB2, PDGFB, TNC
13response to copper ionGO:04668810.3IL1A, SOD3
14platelet degranulationGO:00257610.3PDGFB, TGFB2, TGFB3
15transforming growth factor beta receptor signaling pathwayGO:00717910.2TGFB3, TGFB2, PDGFB
16positive regulation of epithelial cell migrationGO:01063410.2TGFB2, TAC1
17extracellular matrix organizationGO:03019810.1PDGFB, ITGB6, DCN, TNC, TGFB3, TGFB2
18protein phosphorylationGO:0064689.8TGFB2, PTK6, PBK, PDGFB

Molecular functions related to Keratopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1type II transforming growth factor beta receptor bindingGO:00511410.3TGFB2, TGFB3
2water channel activityGO:01525010.1AQP9, AQP3, AQP1
3water transmembrane transporter activityGO:00537210.0AQP9, AQP1

Products for genes affiliated with Keratopathy

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Keratopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet