Keratopathy malady

Wikipedia: Keratopathy can refer to:⁴⁴ more...

MalaCards: Keratopathy is related to band keratopathy and bullous keratopathy. An important gene associated with Keratopathy is TNC (tenascin C), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Akt Signaling. The compounds glycosaminoglycan and egcg have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotypes are respiratory system and craniofacial.

Aliases & Descriptions:

keratopathy 6 8 43

Diseases related to keratopathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 337)

id	Related Disease	Score	Top Affiliating Genes
1	band keratopathy	32.4	GLYR1, PTK6, RPS4X, COL8A2, SLC4A4
2	bullous keratopathy	31.6	BMP2, BMP4, BIRC5, PBK, KERA, CDKN1A
3	keratoconus	25.5	BMP2, BMP4, PBK, KERA, MMP2, FN1
4	cataract	24.8	PAX6, FN1, IL1A, FBN1, FAM46D, IGF1
5	progressive osseous heteroplasia	13.7	BMP2, BMP4, DCN
6	nephrogenic systemic fibrosis	13.6	TIMP1, TGFB1, DCN
7	abdominal aortic aneurysm	13.6	MMP2, FBN1, TIMP1, DCN
8	usual interstitial pneumonia	13.6	TNC, TGFB1, SOD3
9	bladder transitional cell papilloma	13.6	BIRC5, CDKN1A, TP53
10	lichen sclerosus	13.6	IL1A, FBN1, TP53, DCN
11	keloids	13.6	TNC, TGFB1, TGFB2, TGFB3, DCN
12	marfan syndrome	13.6	MMP2, FBN1, TGFB1, DCN
13	osteoporosis, postmenopausal	13.6	IL1A, IGF1, TGFB1, TGFB2
14	osteogenesis imperfecta	13.6	BMP2, IGF1, TNC, DCN
15	aortic valve stenosis	13.5	BMP2, MMP2, FBN1, TNC
16	periostitis	13.5	BMP2, BMP4, IL1A, PDGFB, TGFB1
17	hereditary mucosal leukokeratosis	13.5	ITGB1, MMP2, TP53, TNC
18	diabetic foot ulcers	13.5	IGF1, PDGFB, TGFB1, TGFB2, TGFB3
19	gingival overgrowth	13.5	IL1A, PDGFB, TIMP1, TGFB1, DCN
20	ossification of posterior longitudinal ligament of spine	13.5	BMP2, BMP4, IL1A, IGF1, TGFB1
21	idiopathic pulmonary fibrosis	13.5	IL1A, TNC, PDGFB, TIMP1, TGFB1
22	ureteral obstruction	13.5	CDKN1A, AQP3, TIMP1, TGFB1
23	craniopharyngioma	13.5	IL1A, IGF1, TP53, TNC, PDGFB
24	smooth muscle tumor	13.5	BMP2, CDKN1A, MMP2, TP53
25	fuchs' endothelial dystrophy	13.5	PBK, FBXO7, COL8A2
26	cystadenocarcinoma	13.4	BIRC5, CDKN1A, MMP2, TP53
27	ependymoma	13.4	BIRC5, IL1A, TP53, PDGFB, TGFB2
28	scoliosis	13.4	BMP4, FBN1, IGF1, TGFB1, DCN
29	biliary atresia	13.4	MMP2, IL1A, TIMP1, TGFB1, TGFB2
30	silicosis	13.4	CDKN1A, IL1A, TP53, TIMP1, TGFB1
31	serous cystadenocarcinoma	13.4	BIRC5, CDKN1A, TP53
32	brain glioma	13.4	BMP2, BIRC5, IGF1, TP53, TGFB1
33	duchenne muscular dystrophy	13.4	CDKN1A, MMP2, IGF1, TIMP1, DCN
34	peripheral t-cell lymphoma	13.4	BIRC5, IL1A, TP53, TGFB1, TGFB2, TGFB3
35	oral submucous fibrosis	13.4	BIRC5, MMP2, TP53, TIMP1, TGFB1
36	tongue cancer	13.4	BIRC5, CDKN1A, MMP2, TP53
37	myxoma	13.4	BIRC5, MMP2, TNC, DCN
38	female breast cancer	13.4	CDKN1A, MMP2, IGF1, TP53, TGFB1
39	malignant fibrous histiocytoma	13.4	BMP2, MMP2, IGF1, TP53, SLC4A4
40	endocervicitis	13.4	BMP2, CDKN1A, TP53, TGFB1
41	adenomyosis	13.4	CDKN1A, ITGB1, MMP2, TP53, TIMP1
42	glioblastoma	13.4	BIRC5, CDKN1A, MMP2, TP53, TNC, PDGFB
43	hydrocephalus	13.3	AQP1, IGF1, TP53, TGFB1, TGFB2
44	clear cell renal cell carcinoma	13.3	BIRC5, CDKN1A, MMP2, AQP1, TNC, TGFB1
45	keratosis	13.3	CDKN1A, MMP2, TP53, TNC, KRT12, TGFB2
46	synovitis	13.3	ITGB1, MMP2, IL1A, AQP1, TIMP1, TGFB1
47	cervical squamous cell carcinoma	13.3	BIRC5, CDKN1A, MMP2, TP53, TGFB1
48	corneal disease	13.3	IL1A, AKR1B1, KRT12, TGFB2
49	cerebral primitive neuroectodermal tumor	13.3	BMP2, CDKN1A, IL1A, IGF1, TP53, TNC
50	fibrous histiocytoma	13.3	BMP2, MMP2, IGF1, TP53, PDGFB, SLC4A4

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to keratopathy:

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MGI Mouse Phenotypes related to keratopathy:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.3	PDGFB, FBN1, PAX6
2	craniofacial phenotype	MP:0005382	10.2	SLC4A4, FBN1, PAX6, BMP4
3	endocrine/exocrine gland phenotype	MP:0005379	9.8	AIRE, AQP1
4	limbs/digits/tail phenotype	MP:0005371	9.4	BMP2, BMP4, ITGB1, FN1, FBN1, TGFB2
5	hearing/vestibular/ear phenotype	MP:0005377	9.3	AQP3, IGF1, TNC, TGFB2, AQP1, ITGB1
6	integument phenotype	MP:0010771	9.3	IGJ, TP53, SLC4A4, PENK, FBN1, ITGB6
7	reproductive system phenotype	MP:0005389	9.0	TGFB1, TIMP1, PDGFB, IGJ, FBN1, FN1
8	skeleton phenotype	MP:0005390	9.0	SLC4A4, SOD3, DCN, TGFB3, TGFB2, TP53
9	embryogenesis phenotype	MP:0005380	8.9	DHX9, TGFB3, TGFB2, RNF111, FBN1, PAX6
10	hematopoietic system phenotype	MP:0005397	8.8	GAPDH, SLC4A4, PDGFB, IGJ, AQP9, AQP1
11	immune system phenotype	MP:0005387	8.6	AQP9, AIRE, TP53, DCN, SLC4A4, AQP3
12	digestive/alimentary phenotype	MP:0005381	8.6	SLC4A4, DCN, TGFB3, TGFB2, TGFB1, PTK6
13	tumorigenesis	MP:0002006	8.4	AIRE, TP53, TIMP1, TGFB1, DCN, IGF1
14	muscle phenotype	MP:0005369	8.4	TP53, NID1, PDGFB, TGFB1, TGFB2, DCN
15	growth/size phenotype	MP:0005378	8.2	AIRE, TP53, CTSF, PDGFB, TGFB2, DCN
16	renal/urinary system phenotype	MP:0005367	7.8	TP53, PDGFB, TGFB1, TGFB2, TAC1, DCN
17	vision/eye phenotype	MP:0005391	7.8	BMP4, NID1, PDGFB, KRT12, TGFB1, TGFB2
18	normal phenotype	MP:0002873	7.7	TP53, TNC, NID2, KRT12, TGFB3, SOD3
19	behavior/neurological phenotype	MP:0005386	7.4	TNC, CTSF, NID1, TGFB1, TGFB3, TAC1
20	nervous system phenotype	MP:0003631	7.3	TP53, TNC, CTSF, NID1, RNF111, PDGFB
21	cardiovascular system phenotype	MP:0005385	7.1	TP53, NID1, PDGFB, TIMP1, TGFB1, TGFB2
22	mortality/aging	MP:0010768	6.6	CTSF, RNF111, TGFB2, TGFB3, DHX9, DCN
23	cellular phenotype	MP:0005384	6.6	TP53, COL8A2, NID1, NID2, TGFB1, TGFB2
24	homeostasis/metabolism phenotype	MP:0005376	6.1	TIMP1, PDGFB, TNC, TP53, AIRE, TGFB1

Articles related to keratopathy:

(show all 21)

id	Title	Authors	Year	Affiliating Genes
1	Diabetic keratopathy and treatment by modulation of t he opioid growth factor (OGF)-OGF receptor (OGFr) axis with naltrexone: a revie w. (19683562)	McLaughlin P.J.... Zagon I.S.	2010	PENK, OGFR
2	Differential expression of transforming growth factor -beta isoforms in bullous keratopathy corneas. (20142847)	Strzalka-Mrozik B.... Mazurek U.	2010	TGFB1, TGFB3, TGFB2
3	Quantitative analysis of N-linked glycoproteins in te ar fluid of climatic droplet keratopathy by glycopeptide capture and iTRAQ. (19714880)	Lei Z.... Serra H.M.	2009	IGJ, LACRT
4	The expression of human corneal MMP-2, MMP-9, proMMP-13 and TIMP-1 in bullous keratopathy and keratoconus. (19138000)	PredoviA8 J.... Dekaris I.	2008	MMP2, TIMP1
5	P53, CD95, cathepsin and survivin pathways in Fuchs' dystrophy and pseudophakic bullous keratopathy corneas. (18498065)	Szentmary N.... Suveges I.	2008	TP53, CDKN1A, BIRC5
6	Proteomic analysis of climatic keratopathy droplets. (18378572)	Menegay M.... Bhattacharya S.K.	2008	GAPDH
7	Altered expression of aquaporins in bullous keratopathy and Fuchs' dystrophy corneas. (15385580)	Kenney M.C.... Ljubimov A.V.	2004	AQP1, AQP3, AQP9
8	Insulin-like growth factor-I (IGF-I) and transforming growth factor-beta (TGF-beta) modulate tenascin-C and fibrillin-1 in bullous keratopathy stromal cells in vitro. (14550395)	Kenney M.C.... Brown D.	2003	TNC, FBN1
9	Corneal abnormalities in Pax6+/- small eye mice mimic human aniridia-related keratopathy. (12714618)	Ramaesh T.... Dhillon B.	2003	KRT12
10	Extracellular matrix and Na+,K+-ATPase in human corneas following cataract surgery: comparison with bullous keratopathy and Fuchs' dystrophy corneas. (11805512)	Ljubimov A.V.... Kenney M.C.	2002	TNC, FBN1
11	Altered expression of growth factors and cytokines in keratoconus, bullous keratopathy and diabetic human corneas. (11446768)	Saghizadeh M.... Kenney M.C.	2001	IGF1, BMP4, BMP2
12	Discoveries in research on diabetic keratopathy. (12363257)	Cisarik-Fredenburg P.	2001	AKR1B1
13	Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. (11668187)	Ljubimov A.V.... Kenney M.C.	2001	ITGB1, TNC, ITGA8
14	Increased expression of fibrillin-1 in human corneas with bullous keratopathy. (9603388)	Ljubimov A.V.... Kenney M.C.	1998	TNC, FBN1
15	Tenascin-cytotactin (TN-C) variants in pseudophakic/aphakic bullous keratopathy corneas. (9850274)	Maseruka H.... Bonshek R.E.	1998	TNC
16	Novel splice variants of human tenascin-C mRNA identified in normal and bullous keratopathy corneas. (9603390)	Saghizadeh M.... Ljubimov A.V.	1998	TNC
17	Expression of tenascin-C splice variants in normal and bullous keratopathy human corneas. (9620072)	Ljubimov A.V.... Kenney M.C.	1998	TNC
18	Neurotrophic keratopathy--studies on substance P and the clinical significance of corneal sensation (9436358)	Nishida T.... Mannis M.J.	1997	TAC1, CD160
19	Extracellular matrix alterations in human corneas with bullous keratopathy. (8631643)	Ljubimov A.V.... Kenney M.C.	1996	NID1
20	Detection of mRNA for the cytokines, interleukin-1 alpha and interleukin-8, in corneas from patients with pseudophakic bullous keratopathy. (7657553)	Rosenbaum J.T.... Ansel J.C.	1995	IL1A
21	The origin of keratopathy in chronic allergic eye disease: a histopathological study. (8253220)	Bacon A.S.... Lightman S.L.	1993	RNASE3

Genes related to keratopathy according to GeneCards:

(show top 50)    (show all 53)

id	Symbol	Description	Score	GeneCards Section Context
1	TNC	tenascin C	11.0	Publications
2	SOD3	superoxide dismutase 3, extracellular	11.0
3	FBN1	fibrillin 1	11.0	Publications
4	DCN	decorin	11.0
5	IL1A	interleukin 1, alpha	11.0	Publications
6	TGFB2	transforming growth factor, beta 2	11.0	Publications
7	SLC4A4	solute carrier family 4, sodium bicarbonate cotransporter, member 4	11.0
8	AQP3	aquaporin 3 (Gill blood group)	11.0	Publications
9	RPS4X	ribosomal protein S4, X-linked	11.0
10	PBK	PDZ binding kinase	11.0
11	AQP9	aquaporin 9	11.0	Publications
12	TGFB3	transforming growth factor, beta 3	11.0	Publications
13	ITGB6	integrin, beta 6	11.0	Publications
14	AQP1	aquaporin 1 (Colton blood group)	11.0	Publications
15	NID1	nidogen 1	11.0	Publications
16	PDGFB	platelet-derived growth factor beta polypeptide	11.0	Publications
17	BMP4	bone morphogenetic protein 4	11.0	Publications
18	ITGA8	integrin, alpha 8	11.0	Publications
19	ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	11.0	Publications
20	BMP2	bone morphogenetic protein 2	11.0	Publications
21	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0	Publications
22	BIRC5	baculoviral IAP repeat containing 5	11.0	Publications
23	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
24	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	11.0	Publications
25	TGFB1	transforming growth factor, beta 1	11.0	Publications
26	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
27	TP53	tumor protein p53	11.0	Publications
28	LACRT	lacritin	11.0	Publications
29	IGHA2	immunoglobulin heavy constant alpha 2 (A2m marker)	11.0
30	IGJ	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	11.0	Publications
31	KRT12	keratin 12	11.0	Publications
32	OGFR	opioid growth factor receptor	11.0	Publications
33	COL8A2	collagen, type VIII, alpha 2	11.0
34	KERA	keratocan	11.0
35	CD160	CD160 molecule	11.0	Publications
36	PENK	proenkephalin	11.0	Publications
37	CTSF	cathepsin F	11.0
38	FBXO7	F-box protein 7	11.0
39	GLYR1	glyoxylate reductase 1 homolog (Arabidopsis)	11.0
40	PTK6	PTK6 protein tyrosine kinase 6	11.0
41	ICK	intestinal cell (MAK-like) kinase	11.0
42	FAM46D	family with sequence similarity 46, member D	11.0
43	NID2	nidogen 2 (osteonidogen)	11.0
44	AIRE	autoimmune regulator	11.0
45	RNF111	ring finger protein 111	11.0
46	PAX6	paired box 6	11.0
47	TAC1	tachykinin, precursor 1	11.0	Publications
48	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
49	AKR1B1	aldo-keto reductase family 1, member B1 (aldose reductase)	11.0	Publications
50	DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	11.0

Pathways related to keratopathy according to GeneDecks:

(show top 50)    (show all 102)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	10.2	OGFR, BMP4, ITGA8, ITGB6, IGF1, TGFB3
2	Akt Signaling36	10.1	ITGB6, TGFB2, PENK, PDGFB, BMP2, BMP4
3	Breast Cancer Regulation by Stathmin136	10.0	BMP2, OGFR, PENK, TGFB3, PDGFB, TGFB2
4	Hypertrophic cardiomyopathy (HCM)20	9.9	ITGB6, IGF1, TGFB1, TGFB2, TGFB3, ITGA8
5	JNK Pathway36	9.9	TGFB1, BMP2, BMP4, PDGFB, TP53
6	Dilated cardiomyopathy20	9.9	TGFB3, TGFB2, TGFB1, IGF1, ITGB6, ITGB1
7	CREB Pathway36	9.8	BMP2, BMP4, IGF1, TGFB2, TGFB3, PENK
8	Pathways in cancer20	9.8	TP53, BIRC5, CDKN1A, ITGB1, MMP2, TGFB1
9	eNOS Signaling36	9.7	AQP3, AQP9, PDGFB, TIMP1, TGFB1, TGFB2
10	Ras Pathway36	9.7	ITGB1, PENK, PDGFB, TIMP1, TGFB2, TGFB3
11	IP3 Pathway36	9.6	PENK, IGF1, OGFR, TGFB3, TGFB2, TGFB1
12	mTOR Pathway36	9.6	BMP4, BMP2, TGFB2, TGFB3, PENK, TGFB1
13	Paxillin Interactions36	9.6	PDGFB, BMP2, TGFB2, ITGB1, PENK, TGFB3
14	Inhibition of Angiogenesis by TSP136	9.6	TGFB3, TGFB2, COL8A2, TNC, FBN1, FN1
15	Nanog in Mammalian ESC Pluripotency36	9.6	BMP2, BMP4, TIMP1, TGFB1, TGFB2, TGFB3
16	DHA Signaling36	9.6	OGFR, TGFB1, TGFB2, TGFB3, TIMP1, PDGFB
17	ERK5 Signaling36	9.6	TGFB2, IGF1, BMP2, BMP4, PDGFB, TIMP1
18	eIF2 Pathway36	9.5	TGFB3, OGFR, PENK, TGFB1, TGFB2, BMP2
19	Nuclear Receptor Activation by Vitamin-A36	9.5	TIMP1, TGFB1, TGFB2, TGFB3, PDGFB, PENK
20	NF-KappaB (p50-p65) Pathway36	9.5	BMP4, IGF1, IL1A, PDGFB, TIMP1, TGFB1
21	p70S6K Signaling36	9.5	TGFB1, TGFB2, TGFB3, OGFR, PENK, PDGFB
22	NF-KappaB Family Pathway36	9.5	BMP2, PENK, OGFR, TGFB3, TGFB2, TGFB1
23	Activation of PKC through GPCR36	9.5	IGF1, PDGFB, TIMP1, TGFB1, TGFB2, TGFB3
24	TGF-Beta Pathway36	9.5	TGFB3, OGFR, TGFB2, TIMP1, TGFB1, PENK
25	Renin-Angiotensin Pathway36	9.5	BMP2, BMP4, IGF1, PDGFB, TIMP1, TGFB1
26	Apoptotic Pathways in Synovial Fibroblasts36	9.5	TP53, PDGFB, TIMP1, TGFB1, OGFR, TGFB2
27	p53 Mediated Apoptosis36	9.5	TGFB2, PENK, TGFB3, OGFR, PDGFB, TIMP1
28	Telomerase Components in Cell Signaling36	9.5	PDGFB, PENK, OGFR, TGFB3, TGFB2, TGFB1
29	Mitochondrial Apoptosis36	9.5	BMP2, BMP4, IGF1, TP53, PDGFB, TIMP1
30	Rap1 Pathway36	9.5	IGF1, BMP4, PDGFB, ITGB6, TIMP1, TGFB1
31	PAK Pathway36	9.5	TGFB2, BMP2, BMP4, OGFR, PDGFB, TIMP1
32	Cellular Apoptosis Pathway36	9.4	TGFB2, BMP4, BMP2, TP53, PDGFB, TIMP1
33	MAPK Family Pathway36	9.4	PDGFB, TIMP1, TGFB1, TGFB2, PENK, OGFR
34	Glioma Invasiveness36	9.4	BMP2, PENK, TGFB3, TGFB2, BMP4, ITGA8
35	Tec Kinases Signaling36	9.4	TGFB2, TGFB3, PENK, ITGB1, BMP4, ITGA8
36	PPAR Pathway36	9.3	PENK, ITGB1, PDGFB, TIMP1, TGFB1, TGFB2
37	Rac1 Pathway36	9.3	BMP2, BMP4, ITGA8, ITGB6, IGF1, PENK
38	JAK-STAT Pathway36	9.3	PENK, TGFB3, TGFB2, TGFB1, TIMP1, IGF1
39	Pancreatic Adenocarcinoma36	9.3	TGFB3, BMP2, BMP4, BIRC5, TGFB2, CDKN1A
40	Antioxidant Action of Vitamin-C36	9.3	BMP4, BMP2, IGF1, PDGFB, TIMP1, TGFB1
41	p38 Signaling36	9.2	TGFB2, BMP2, BMP4, IL1A, TP53, PDGFB
42	UPA-UPAR Pathway36	9.1	ITGB6, ITGA8, COL8A2, TNC, MMP2, FBN1
43	14-3-3 Induced Intracellular Signaling36	9.1	PDGFB, TIMP1, TGFB1, TGFB2, IGF1, PENK
44	PTEN Pathway36	9.0	BMP4, PENK, ITGA8, ITGB6, FN1, FBN1
45	ILK Signaling36	8.8	PDGFB, TIMP1, TGFB1, TGFB2, PENK, COL8A2
46	Rho Family GTPases36	8.6	COL8A2, PENK, TIMP1, TGFB1, TGFB2, BMP4
47	Molecular Mechanisms of Cancer36	8.6	PENK, TGFB3, TGFB2, TP53, FBN1, FN1
48	Phospholipase-C Pathway36	8.5	BMP4, BMP2, TGFB1, TIMP1, PDGFB, COL8A2
49	MAPK Signaling36	8.3	TGFB1, BMP4, ITGA8, ITGB1, ITGB6, FN1
50	ERK Signaling36	8.1	BMP2, PAX6, ITGA8, ITGB1, ITGB6, FN1

Compounds related to keratopathy according to GeneDecks:

(show top 50)    (show all 128)

id	Compound	Score	Top Affiliating Genes
1	glycosaminoglycan32	10.5	BMP2, TNC, TGFB3, DCN
2	egcg32	10.2	TGFB2, IL1A, TIMP1
3	hydroxyproline32 18	11.1	TGFB1, TIMP1, ITGB1, MMP2, DCN, FBN1
4	alginate32	10.0	MMP2, IGF1, TIMP1, TGFB1, TGFB2, TGFB3
5	procollagen32	9.9	PDGFB, TGFB1, BMP2, TNC, IGF1, IL1A
6	ly29400232	9.9	TGFB1, TIMP1, FN1, MMP2
7	titanium32	9.8	TNC, FN1, DCN, BMP4, BMP2, ITGB1
8	hyaluronic acid32 18	10.8	FBN1, DCN, RNASE3, TNC, FN1
9	calcitriol32 42 9 18 9	13.7	IL1A, CDKN1A, ITGB1, TGFB1, BMP2, IGF1
10	tgf beta132	9.7	CDKN1A, MMP2, TGFB3, FN1, FBN1, TNC
11	grgdsp32	9.7	TIMP1, FN1, MMP2
12	n acetylcysteine32	9.7	CDKN1A, BIRC5, MMP2, TP53, RNASE3, TIMP1
13	heparan sulfate32 18	10.6	NID1, DCN, BMP4, BMP2, FN1, TNC
14	matrigel32	9.5	TNC, TGFB2, BMP2, TIMP1, ITGB1, MMP2
15	pge232	9.5	TGFB2, AKR1B1, FN1, IL1A, BMP4, BMP2
16	pdtc32	9.4	MMP2, TGFB1, TP53, IL1A, CDKN1A, BIRC5
17	curcumin32	9.4	MMP2, AKR1B1, CDKN1A, BIRC5, TP53, TIMP1
18	h2o232	9.3	TAC1, PENK, RNASE3, AKR1B1, SOD3
19	vitamin d32	9.3	BMP2, FN1, TGFB2, CDKN1A, IL1A, IGF1
20	progesterone32 42 9 18 9	13.1	PENK, TGFB3, IGF1, BMP2, BMP4, BIRC5
21	ribonucleic acid32	9.1	IL1A, MMP2, TIMP1, BMP4, BMP2, IGF1
22	guanidine hydrochloride32	9.1	DCN, TIMP1, FN1, BMP2, BMP4, GAPDH
23	ascorbic acid32 18	10.0	MMP2, IL1A, BMP4, FBN1, SOD3, GAPDH
24	paraffin32	9.0	BIRC5, CDKN1A, ITGB1, MMP2, FN1, AQP1
25	glutamate32	8.9	NID1, SLC4A4, MMP2, TNC, TIMP1, TGFB2
26	pd 98,05932	8.9	FN1, MMP2, ITGB1, BIRC5, BMP4, IGF1
27	thymidine32 18	9.8	FN1, CDKN1A, BIRC5, BMP4, BMP2, TGFB2
28	genistein32 9 18 9	11.8	DCN, BMP2, TIMP1, TGFB2, AKR1B1, IGF1
29	sb 20358032 42	9.8	IGF1, CDKN1A, TGFB1, TIMP1, ITGB1, TP53
30	5fluorouracil32	8.7	TGFB3, GAPDH, TGFB2, TP53, MMP2, TAC1
31	indomethacin32 9 9	10.7	IL1A, FN1, BIRC5, AKR1B1, TIMP1, TGFB2
32	steroid32	8.3	AQP1, DCN, TAC1, TGFB3, RNASE3, IGF1
33	oligonucleotide32	8.3	BMP2, BMP4, BIRC5, CDKN1A, AQP1, AQP3
34	heparin32 9 18 9	11.2	SOD3, TAC1, GAPDH, DCN, NID1, TNC
35	dexamethasone32 42 34 9 9	12.1	FN1, BMP2, BMP4, TIMP1, TGFB1, TGFB2
36	cysteine32	8.1	FN1, FBN1, AQP1, AKR1B1, CTSF, MMP2
37	estrogen32	8.0	BMP2, GAPDH, TAC1, TGFB3, TGFB2, BMP4
38	lactate32	7.9	AQP9, RNASE3, BMP2, BIRC5, MMP2, FN1
39	glutamine32	7.9	FN1, TAC1, ITGB1, TGFB2, TGFB1, TIMP1
40	creatinine32	7.9	IL1A, FN1, MMP2, AQP1, AQP3, IGF1
41	cyclosporin a32 42	8.8	GAPDH, BMP4, TGFB2, BMP2, CD160, ITGB1
42	alanine32	7.7	DCN, MMP2, FN1, FBN1, AKR1B1, TIMP1
43	nitric oxide32 9 18 9	10.6	GAPDH, AQP1, RNASE3, PDGFB, TIMP1, TGFB2
44	cycloheximide32	7.5	BMP4, TNC, PDGFB, TIMP1, TGFB1, TGFB2
45	arginine32	7.5	SOD3, BMP2, PAX6, FN1, IL1A, FBN1
46	actinomycin d32	7.3	BMP2, DHX9, BMP4, BIRC5, CDKN1A, TAC1
47	retinoic acid32 42 18	9.0	BMP2, BMP4, BIRC5, PAX6, CDKN1A, ITGB1
48	tyrosine32	6.9	TIMP1, CDKN1A, TGFB2, TGFB3, TAC1, PDGFB
49	serine32	6.7	TNC, TP53, AIRE, AKR1B1, NID1, PDGFB
50	vegf32	6.7	BMP2, BMP4, GAPDH, SOD3, AKR1B1, RNASE3

Cellular components related to keratopathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	basolateral plasma membrane	GO:016323	10.0	PDGFB, AQP9, AQP3, AQP1, SLC4A4
2	alpha8-beta1 integrin complex	GO:034678	10.0	ITGA8, ITGB1
3	basement membrane	GO:005604	9.7	TGFB2, TIMP1, NID2, COL8A2, FBN1, ITGB1
4	cell surface	GO:009986	9.7	TGFB3, TGFB2, TGFB1, PDGFB, IL1A, ITGB1
5	platelet alpha granule lumen	GO:031093	9.4	TGFB3, TGFB2, TGFB1, TIMP1, PDGFB, IGF1
6	extracellular matrix	GO:031012	9.1	SOD3, DCN, TGFB3, TGFB2, NID2, NID1
7	proteinaceous extracellular matrix	GO:005578	9.1	TGFB1, COL8A2, TNC, FBN1, FN1, MMP2
8	extracellular space	GO:005615	8.1	TGFB1, TGFB2, TGFB3, TAC1, DCN, SOD3
9	extracellular region	GO:005576	7.2	BMP2, RNASE3, PDGFB, TIMP1, TGFB1, TGFB2

Biological processes related to keratopathy according to GeneDecks:

(show top 50)    (show all 52)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of macrophage cytokine production	GO:010936	10.6	TGFB3, TGFB2, TGFB1
2	frontal suture morphogenesis	GO:060364	10.6	TGFB3, TGFB2, TGFB1
3	SMAD protein import into nucleus	GO:007184	10.6	TGFB1, TGFB2, TGFB3
4	response to laminar fluid shear stress	GO:034616	10.5	TGFB3, TGFB2, TGFB1
5	positive regulation of ossification	GO:045778	10.5	BMP2, BMP4, TGFB2
6	negative regulation of release of sequestered calcium ion into cytosol	GO:051280	10.5	TGFB1, TGFB2
7	positive regulation of SMAD protein import into nucleus	GO:060391	10.5	TGFB3, TGFB1, BMP4
8	positive regulation of epithelial to mesenchymal transition	GO:010718	10.5	BMP2, TGFB1, TGFB2, TGFB3
9	cellular response to dexamethasone stimulus	GO:071549	10.5	TGFB1, AQP1, BMP4
10	pathway-restricted SMAD protein phosphorylation	GO:060389	10.5	TGFB2, TGFB1, BMP2
11	odontogenesis	GO:042476	10.5	TGFB3, TGFB2, AQP3, AQP1, BMP4
12	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:010862	10.4	TGFB3, TGFB1, BMP4, BMP2
13	positive regulation of cell division	GO:051781	10.4	TGFB3, TGFB2, TGFB1, PDGFB, IL1A
14	positive regulation of bone mineralization	GO:030501	10.4	TGFB3, TGFB1, BMP4, BMP2
15	response to vitamin D	GO:033280	10.4	TGFB2, TGFB1, AQP3
16	response to retinoic acid	GO:032526	10.4	TGFB2, AQP3, BMP4, BMP2
17	cardiac muscle cell differentiation	GO:055007	10.4	ITGB1, BMP4, BMP2
18	cell growth	GO:016049	10.4	TGFB3, TGFB2, TGFB1, PDGFB
19	positive regulation of fibroblast proliferation	GO:048146	10.4	PDGFB, IGF1, AQP1, CDKN1A
20	cellular response to growth factor stimulus	GO:071363	10.4	BMP2, BMP4, TGFB1, TGFB3
21	inner ear development	GO:048839	10.4	TGFB3, TGFB2, TGFB1, IGF1, BMP2
22	response to progesterone stimulus	GO:032570	10.4	TGFB3, TGFB2, TGFB1
23	positive regulation of collagen biosynthetic process	GO:032967	10.3	TGFB3, TGFB1, BMP4
24	aging	GO:007568	10.3	DCN, TGFB3, TGFB2, TGFB1, TIMP1
25	cellular response to ionizing radiation	GO:071479	10.3	TP53, ITGB1, CDKN1A
26	salivary gland morphogenesis	GO:007435	10.3	TGFB3, TGFB2, TGFB1, PAX6
27	positive regulation of epithelial cell proliferation	GO:050679	10.3	TGFB1, IGF1, LACRT, BMP4
28	BMP signaling pathway involved in heart induction	GO:003130	10.3	BMP4, BMP2
29	negative regulation of DNA replication	GO:008156	10.3	TGFB3, TGFB1, TP53
30	response to hypoxia	GO:001666	10.2	SOD3, TGFB3, TGFB2, TGFB1, PDGFB, IL1A
31	face morphogenesis	GO:060325	10.2	TGFB3, TGFB2, TGFB1
32	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.2	LACRT, ITGB1, IGF1, TP53, PDGFB
33	neuron fate commitment	GO:048663	10.2	TGFB2, PAX6, BMP4
34	positive regulation of reactive oxygen species metabolic process	GO:2000379	10.2	PDGFB, TP53, CDKN1A
35	positive regulation of protein secretion	GO:050714	10.2	TGFB3, TGFB2, TGFB1
36	cell-matrix adhesion	GO:007160	10.2	NID2, NID1, ITGB6, ITGB1, ITGA8
37	negative regulation of epithelial cell proliferation	GO:050680	10.2	BMP4, PAX6, TGFB1, TGFB2
38	cornea development in camera-type eye	GO:061303	10.2	KRT12, KERA, PAX6
39	ossification involved in bone remodeling	GO:043932	10.2	TGFB1, TGFB3
40	transforming growth factor beta receptor signaling pathway	GO:007179	10.0	TGFB3, TGFB2, TGFB1, PDGFB, RNF111, TP53
41	bone mineralization involved in bone maturation	GO:035630	9.9	IGF1, BMP2
42	positive regulation of cell proliferation	GO:008284	9.9	TGFB2, TGFB1, TIMP1, PDGFB, RPS4X, IGF1
43	negative regulation of cell proliferation	GO:008285	9.8	TGFB3, TGFB2, TGFB1, TP53, IGF1, IL1A
44	protein phosphorylation	GO:006468	9.8	TGFB2, TGFB1, PDGFB, PTK6, ICK, PBK
45	platelet degranulation	GO:002576	9.7	FN1, TGFB3, TGFB2, TGFB1, TIMP1, PDGFB
46	platelet activation	GO:030168	9.7	TGFB3, TGFB2, TGFB1, TIMP1, PDGFB, IGF1
47	response to wounding	GO:009611	9.7	TGFB2, TGFB1, PDGFB, TNC, FN1, PAX6
48	blood coagulation	GO:007596	9.4	TGFB3, TGFB2, TGFB1, TIMP1, PDGFB, TP53
49	positive regulation of transcription, DNA-dependent	GO:045893	9.1	TGFB3, TGFB1, PDGFB, RNF111, TP53, AIRE
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.1	TGFB3, TGFB1, RNF111, TP53, AIRE, IGF1

Molecular functions related to keratopathy according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	water channel activity	GO:015250	10.2	AQP1, AQP3, AQP9
2	type II transforming growth factor beta receptor binding	GO:005114	10.1	TGFB1, TGFB2, TGFB3
3	growth factor activity	GO:008083	9.7	TGFB3, TGFB2, TGFB1, PDGFB, IGF1, LACRT
4	protein N-terminus binding	GO:047485	9.6	DCN, TGFB2, TGFB1, TP53, LACRT
5	protein heterodimerization activity	GO:046982	9.6	TGFB3, TGFB2, TGFB1, PDGFB, TP53, ITGB1
6	collagen binding	GO:005518	9.3	LACRT, DCN, PDGFB, NID2, NID1, FN1
7	protein binding	GO:005515	5.2	PDGFB, RNF111, NID2, PTK6, TP53, TIMP1