MCID: KRT008
MIFTS: 51

Keratopathy malady

Eye diseases category
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Summaries for Keratopathy

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Wikipedia:65 Keratopathy can refer to: more...

MalaCards based summary: Keratopathy is related to cataract and bullous keratopathy. An important gene associated with Keratopathy is SOD3 (superoxide dismutase 3, extracellular), and among its related pathways are Angiogenesis and Integrin cell surface interactions. The compounds uric acid and manganese superoxide have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and brain, and related mouse phenotypes are cardiovascular system and craniofacial.

Aliases & Classifications for Keratopathy

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Keratopathy, Aliases & Descriptions:

Name: Keratopathy 30 8 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:2283
NCIt39 C27012

Related Diseases for Keratopathy

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Graphical network of the top 20 diseases related to Keratopathy:



Diseases related to keratopathy

Symptoms for Keratopathy

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Drugs & Therapeutics for Keratopathy

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Drug clinical trials:

Search ClinicalTrials for Keratopathy

Search NIH Clinical Center for Keratopathy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Keratopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Keratopathy:
Adipose-derived stem cells for treatment of bilateral limbic-associated keratopathy
Embryonic/Adult Cultured Cells Related to Keratopathy:
Adipose-derived stem cells

Genetic Tests for Keratopathy

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Anatomical Context for Keratopathy

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MalaCards organs/tissues related to Keratopathy:

32
Endothelial, Eye, Brain, Lung, Skin, Testes, T cells, B cells

Animal Models for Keratopathy or affiliated genes

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MGI Mouse Phenotypes related to Keratopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.4FBN1, TGFB2, SLC4A4, IL1A
2MP:00053828.3FBN1, DCN, TGFB2, SLC4A4
3MP:00053678.2TGFB2, SLC4A4, DCN, FBN1
4MP:00053698.1SLC4A4, TGFB2, DCN, FBN1
5MP:00053907.9SOD3, TGFB2, DCN, FBN1, SLC4A4
6MP:00053977.5FBN1, DCN, TGFB2, IL1A, SLC4A4
7MP:00107687.5FBN1, SLC4A4, SOD3, TGFB2, DCN
8MP:00053877.3SLC4A4, IL1A, SOD3, TGFB2, DCN, FBN1
9MP:00053766.9FBN1, DCN, SLC4A4, IL1A, SOD3, TGFB2

Publications for Keratopathy

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Articles related to Keratopathy:

(show top 50)    (show all 649)
idTitleAuthorsYear
1
Re: Arora etA al.: Role of Corneal Collagen Cross-Linking in Pseudophakic Bullous Keratopathy: AA Clinicopathological Study (Ophthalmology 2013;120:2413-8). (25015213)
2014
2
Midinfrared Laser Pancorneal Coagulation as a Method of Treatment for Painful Bullous Keratopathy. (23974894)
2013
3
Treatment of bullous keratopathy with corneal collagen cross-linking in two dogs. (24373539)
2013
4
Autologous tragal perichondrium transplantation: a novel approach for the management of painful bullous keratopathy. (23730105)
2013
5
Genetic background and climatic droplet keratopathy incidence in a mapuche population from Argentina. (24040292)
2013
6
New findings for an old disease: morphological studies on pseudoexfoliation syndrome-related keratopathy and binocular asymmetry. (24104940)
2013
7
In vivo confocal microscopy study of climatic droplet keratopathy. (22538217)
2012
8
Excimer laser phototherapeutic keratectomy for the treatment of silicone oil-induced band-shaped keratopathy. (21455078)
2011
9
Long-term outcome of central toxic keratopathy after photorefractive keratectomy. (21926568)
2011
10
Reproducibility of cornea measurements in anterior segment OCT images of normal eyes and eyes with bullous keratopathy analyzed with the Zhongshan Assessment Program. (21828152)
2011
11
Confocal microscopy of contact lens keratitis presenting as central toxic keratopathy. (21808198)
2011
12
Penetrating keratoplasty for bullous keratopathy after trabeculectomy. (18369373)
2009
13
In vivo morphometry of corneal endothelial cells in pseudoexfoliation keratopathy with glaucoma and cataract. (19365152)
2009
14
Neuroparalytic keratopathy as the first sign of a cerebral meningioma. (17894293)
2007
15
Persistent epithelial defects due to neurotrophic keratopathy treated with a substance p-derived peptide and insulin-like growth factor 1. (18158595)
2007
16
Ring keratopathy in a patient with psoriatic arthritis and ulcerative rectocolitis. (17365809)
2007
17
Therapeutic options for the management of early neurotrophic keratopathy: a case report and review. (17000411)
2006
18
Climatic droplet keratopathy in the Argentine Patagonia. (16564815)
2006
19
Anaesthetic abuse keratopathy as a manifestation of ocular Munchausen's syndrome. (16451265)
2006
20
Confocal microscopy of Thygeson's superficial punctate keratopathy. (15670099)
2005
21
Dendritic keratopathy in ocular rosacea. (15968176)
2005
22
The implications of the upregulation of ICAM-1/VCAM-1 expression of corneal fibroblasts on the pathogenesis of allergic keratopathy. (16303942)
2005
23
Infectious crystalline keratopathy histopathological characteristics. (14641273)
2003
24
Management of aniridic keratopathy with keratolimbal allograft: a limbal stem cell transplantation technique. (12511357)
2003
25
Filamentary keratopathy: a non-contact photomicrographic in vivo study in the human cornea. (14552592)
2003
26
Keratopathy in congenital aniridia. (17075635)
2003
27
Epithelial infectious crystalline keratopathy. (11228305)
2001
28
Neurotrophic keratopathy. (11352446)
2001
29
Ultrastructural morphology and expression of proteoglycans, betaig-h3, tenascin-C, fibrillin-1, and fibronectin in bullous keratopathy. (11371495)
2001
30
Clinical course of hurricane keratopathy. (10684839)
2000
31
Infectious crystalline keratopathy. (10656309)
2000
32
Delayed mustard gas keratopathy: clinical findings and confocal microscopy. (10577594)
1999
33
Infectious crystalline keratopathy: a case report. (9810093)
1998
34
The current situation of lagophthalmos and keratopathy of leprosy in PR China. (9598407)
1998
35
Association of tear lipid layer interference patterns with superficial punctate keratopathy. (9634902)
1998
36
Vortex keratopathy associated with atovaquone. (7485371)
1995
37
Pseudophakic bullous keratopathy and intraocular lens fixation. To suture or not: that is the question! (7945030)
1994
38
Climatic droplet keratopathy. (7936560)
1994
39
The relationship between cataract and climatic droplet keratopathy in Mongolia. (7825419)
1994
40
Climatic droplet keratopathy, exfoliation syndrome, and cataract. (1768663)
1991
41
The dilemma of pseudophakic bullous keratopathy. (2674810)
1989
42
Late development of localized band keratopathy in relation to a Molteno tube. (2743783)
1989
43
Results of penetrating keratoplasty for pseudophakic bullous keratopathy with the exchange of an intraocular lens. (2804025)
1989
44
The bandage lens in bullous keratopathy. (2594381)
1989
45
Intraocular lens replacement in pseudophakic bullous keratopathy. (3901432)
1985
46
Visual acuity, refractive error, and astigmatism following corneal transplantation for pseudophakic bullous keratopathy. (3909036)
1985
47
Band keratopathy in hypercalcemia of myeloma. (7074461)
1982
48
X-linked recessive ocular dystrophy with band keratopathy. (7258937)
1981
49
Endothelial degeneration and posterior collagenous proliferation in aphakic bullous keratopathy. (306751)
1978
50
Bullous keratopathy (Fuchs' endothelial dystrophy) treated systemically with 4-trans-amino-cyclohexano-carboxylic acid. (302548)
1977

Variations for Keratopathy

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Expression for genes affiliated with Keratopathy

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Expression patterns in normal tissues for genes affiliated with Keratopathy

Search GEO for disease gene expression data for Keratopathy.

Pathways for genes affiliated with Keratopathy

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Compounds for genes affiliated with Keratopathy

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Compounds related to Keratopathy according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1uric acid44 2410.8SOD3, TGFB2
2manganese superoxide449.7IL1A, SOD3
3neopterin449.6IL1A, TGFB2
4p003449.6TGFB2, TNC
5neurocan449.6DCN, TNC
6titanium449.6DCN, TNC
7alginate449.5DCN, TGFB2
8hydroxyproline44 24 1111.4FBN1, DCN
9hydrocortisone44 2 61 1112.4IL1A, TGFB2
101,25 dihydroxy vitamin d3449.3IL1A, TGFB2
11homocysteine44 2410.3SOD3, FBN1
12h2o2449.2IL1A, SOD3, TNC
13cycloheximide449.2TNC, TGFB2, IL1A
14carboplatin44 50 1111.1IL1A, DCN
15matrigel449.1TGFB2, DCN, TNC
16chondroitin sulfate44 2410.1FBN1, TNC, DCN
17paraffin449.1TGFB2, DCN, TNC
18procollagen449.0IL1A, DCN, TNC
19ribonucleic acid448.9DCN, TGFB2, IL1A
20vitamin d448.9FBN1, TGFB2, SOD3, IL1A
21sodium dodecylsulfate448.9IL1A, DCN, FBN1
22genistein44 28 61 2 24 1113.9DCN, TGFB2, IL1A
23cyclosporin a44 28 6110.9IL1A, TGFB2, DCN
24pge2448.9IL1A, TGFB2, DCN
25oligonucleotide448.9TNC, DCN, TGFB2
26progesterone44 28 61 24 1112.8FBN1, TNC, TGFB2, IL1A
27heparan sulfate44 249.8SOD3, DCN, TNC, FBN1
28aspartate448.8SLC4A4, IL1A, DCN
29tgf beta1448.7FBN1, TNC, DCN, TGFB2
30estrogen448.6FBN1, TNC, DCN, TGFB2
31glycosaminoglycan448.6IL1A, TGFB2, DCN, TNC
32nitric oxide44 24 1110.6DCN, TGFB2, SOD3, IL1A
33creatinine448.6TNC, DCN, TGFB2, IL1A
34dexamethasone44 50 28 1111.5TNC, DCN, TGFB2, IL1A
35ascorbic acid44 249.5FBN1, TNC, TGFB2, SOD3, IL1A
36arginine448.5FBN1, DCN, SOD3, IL1A
37cysteine448.3FBN1, TNC, DCN, TGFB2, SOD3
38vegf448.2TNC, DCN, TGFB2, SOD3, IL1A
39tyrosine448.1SLC4A4, TGFB2, DCN, TNC, FBN1
40hyaluronic acid44 249.1IL1A, TGFB2, DCN, TNC, FBN1
41retinoic acid44 249.1IL1A, TGFB2, DCN, TNC, FBN1
42heparin44 28 24 1110.7FBN1, TNC, DCN, TGFB2, SOD3, IL1A
43serine447.7FBN1, TNC, DCN, TGFB2, SOD3, IL1A
44glutamate447.6FBN1, TNC, DCN, TGFB2, IL1A, SLC4A4

GO Terms for genes affiliated with Keratopathy

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Cellular components related to Keratopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.3SOD3, DCN
2basement membraneGO:0056049.2TNC, FBN1
3extracellular matrixGO:0310128.0SOD3, TGFB2, DCN, TNC, FBN1
4extracellular spaceGO:0056157.3FBN1, TNC, DCN, TGFB2, SOD3, IL1A
5extracellular regionGO:0055767.2FBN1, TNC, DCN, TGFB2, SOD3, IL1A

Biological processes related to Keratopathy according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to woundingGO:0096119.6TGFB2, TNC
2response to copper ionGO:0466889.6IL1A, SOD3
3positive regulation of cell divisionGO:0517819.5TGFB2, IL1A
4response to mechanical stimulusGO:0096129.1DCN, TNC
5extracellular matrix disassemblyGO:0226179.1DCN, FBN1
6wound healingGO:0420608.9TNC, DCN, TGFB2
7kidney developmentGO:0018228.8DCN, FBN1
8extracellular matrix organizationGO:0301988.4TGFB2, DCN, TNC, FBN1

Molecular functions related to Keratopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:0055079.5IL1A, SOD3

Products for genes affiliated with Keratopathy

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Sources for Keratopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet