Aliases & Classifications for Keratopathy

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Keratopathy, Aliases & Descriptions:

Name: Keratopathy 30 9 11 60


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Disease Ontology9 DOID:2283
NCIt38 C27012

Summaries for Keratopathy

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Wikipedia:63 Keratopathy can refer to: more...

MalaCards based summary: Keratopathy is related to cataract and bullous keratopathy. An important gene associated with Keratopathy is SOD3 (superoxide dismutase 3, extracellular), and among its related pathways are Angiogenesis and Integrin cell surface interactions. The compounds uric acid and manganese superoxide have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and brain, and related mouse phenotypes are cardiovascular system and craniofacial.

Related Diseases for Keratopathy

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Diseases related to Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1cataract30.7TGFB2, SLC4A4
2bullous keratopathy30.5IL1A, SOD3, TGFB2, DCN, TNC, FBN1
3corneal disease30.4TGFB2, IL1A
4keratoconus30.3SOD3, DCN, TNC
5pneumonia30.2SOD3, TGFB2
6uveitis30.2IL1A, TGFB2
7myopia30.1FBN1, DCN
8arthritis30.0FBN1, SOD3, IL1A
9melanoma29.5TNC, DCN, TGFB2, IL1A
10rheumatoid arthritis29.4IL1A, SOD3, DCN
11atherosclerosis29.3IL1A, SOD3, DCN, FBN1
12band keratopathy10.8
13endotheliitis10.7
14neurotrophic keratopathy10.7
15keratitis10.5
16aniridia10.4
17aortic aneurysm10.4FBN1
18loeys-dietz syndrome10.4FBN1
19lagophthalmos10.3
20myeloma10.3
21multiple myeloma10.3
22vitreoretinopathy, neovascular inflammatory10.2TNC, TGFB2
23hyperhomocysteinemia10.2FBN1, SOD3
24herpes zoster10.2
25fuchs' endothelial dystrophy10.2
26hypercalcemia10.1
27herpes simplex10.1
28pulmonary fibrosis, idiopathic10.1IL1A, TNC
29dermatomyositis10.1IL1A, FBN1
30insulin-like growth factor i10.0
31fabry disease10.0
32leprosy10.0
33cystinosis10.0
34xerophthalmia10.0
35choroiditis10.0
36keratomalacia10.0
37astigmatism10.0
38corneal deposit10.0
39corneal neovascularization10.0
40corneal ulcer10.0
41hyperparathyroidism10.0
42ptosis10.0
43scleritis10.0
44strabismus10.0
45mycobacterium abscessus10.0
46marfan syndrome10.0DCN, FBN1
47abdominal aortic aneurysm10.0DCN, FBN1
48ehlers-danlos syndrome10.0FBN1, DCN
49gingival overgrowth10.0DCN, IL1A
50acute myocardial infarction10.0SOD3, TNC

Graphical network of the top 20 diseases related to Keratopathy:



Diseases related to keratopathy

Symptoms for Keratopathy

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Drugs & Therapeutics for Keratopathy

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Drug clinical trials:

Search ClinicalTrials for Keratopathy

Search NIH Clinical Center for Keratopathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Keratopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Keratopathy:
Adipose-derived stem cells for treatment of bilateral limbic-associated keratopathy
Embryonic/Adult Cultured Cells Related to Keratopathy:
Adipose-derived stem cells

Genetic Tests for Keratopathy

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Anatomical Context for Keratopathy

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MalaCards organs/tissues related to Keratopathy:

31
Endothelial, Eye, Brain, Lung, Skin, Testes, T cells, B cells

Animal Models for Keratopathy or affiliated genes

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MGI Mouse Phenotypes related to Keratopathy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.4SLC4A4, IL1A, TGFB2, FBN1
2MP:00053828.3SLC4A4, TGFB2, DCN, FBN1
3MP:00053678.2FBN1, DCN, TGFB2, SLC4A4
4MP:00053698.1FBN1, DCN, TGFB2, SLC4A4
5MP:00053907.9FBN1, DCN, TGFB2, SOD3, SLC4A4
6MP:00053977.5SLC4A4, IL1A, TGFB2, DCN, FBN1
7MP:00107687.5FBN1, DCN, TGFB2, SOD3, SLC4A4
8MP:00053877.3FBN1, DCN, TGFB2, SOD3, IL1A, SLC4A4
9MP:00053766.9SLC4A4, FBN1, TNC, DCN, TGFB2, SOD3

Publications for Keratopathy

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Articles related to Keratopathy:

(show top 50)    (show all 663)
idTitleAuthorsYear
1
Re: Arora etA al.: Role of Corneal Collagen Cross-Linking in Pseudophakic Bullous Keratopathy: AA Clinicopathological Study (Ophthalmology 2013;120:2413-8). (25015213)
2014
2
Neurotrophic keratopathy due to dorsolateral medullary infarction (Wallenberg syndrome): case report and literature review. (25472780)
2014
3
Midinfrared Laser Pancorneal Coagulation as a Method of Treatment for Painful Bullous Keratopathy. (23974894)
2013
4
Treatment of bullous keratopathy with corneal collagen cross-linking in two dogs. (24373539)
2013
5
Autologous tragal perichondrium transplantation: a novel approach for the management of painful bullous keratopathy. (23730105)
2013
6
Genetic background and climatic droplet keratopathy incidence in a mapuche population from Argentina. (24040292)
2013
7
New findings for an old disease: morphological studies on pseudoexfoliation syndrome-related keratopathy and binocular asymmetry. (24104940)
2013
8
In vivo confocal microscopy study of climatic droplet keratopathy. (22538217)
2012
9
Excimer laser phototherapeutic keratectomy for the treatment of silicone oil-induced band-shaped keratopathy. (21455078)
2011
10
Long-term outcome of central toxic keratopathy after photorefractive keratectomy. (21926568)
2011
11
Reproducibility of cornea measurements in anterior segment OCT images of normal eyes and eyes with bullous keratopathy analyzed with the Zhongshan Assessment Program. (21828152)
2011
12
Confocal microscopy of contact lens keratitis presenting as central toxic keratopathy. (21808198)
2011
13
Penetrating keratoplasty for bullous keratopathy after trabeculectomy. (18369373)
2009
14
In vivo morphometry of corneal endothelial cells in pseudoexfoliation keratopathy with glaucoma and cataract. (19365152)
2009
15
Neuroparalytic keratopathy as the first sign of a cerebral meningioma. (17894293)
2007
16
Persistent epithelial defects due to neurotrophic keratopathy treated with a substance p-derived peptide and insulin-like growth factor 1. (18158595)
2007
17
Ring keratopathy in a patient with psoriatic arthritis and ulcerative rectocolitis. (17365809)
2007
18
Therapeutic options for the management of early neurotrophic keratopathy: a case report and review. (17000411)
2006
19
Climatic droplet keratopathy in the Argentine Patagonia. (16564815)
2006
20
Anaesthetic abuse keratopathy as a manifestation of ocular Munchausen's syndrome. (16451265)
2006
21
Confocal microscopy of Thygeson's superficial punctate keratopathy. (15670099)
2005
22
Dendritic keratopathy in ocular rosacea. (15968176)
2005
23
The implications of the upregulation of ICAM-1/VCAM-1 expression of corneal fibroblasts on the pathogenesis of allergic keratopathy. (16303942)
2005
24
Infectious crystalline keratopathy histopathological characteristics. (14641273)
2003
25
Management of aniridic keratopathy with keratolimbal allograft: a limbal stem cell transplantation technique. (12511357)
2003
26
Filamentary keratopathy: a non-contact photomicrographic in vivo study in the human cornea. (14552592)
2003
27
Keratopathy in congenital aniridia. (17075635)
2003
28
Epithelial infectious crystalline keratopathy. (11228305)
2001
29
Neurotrophic keratopathy. (11352446)
2001
30
Ultrastructural morphology and expression of proteoglycans, betaig-h3, tenascin-C, fibrillin-1, and fibronectin in bullous keratopathy. (11371495)
2001
31
Clinical course of hurricane keratopathy. (10684839)
2000
32
Infectious crystalline keratopathy. (10656309)
2000
33
Delayed mustard gas keratopathy: clinical findings and confocal microscopy. (10577594)
1999
34
Infectious crystalline keratopathy: a case report. (9810093)
1998
35
The current situation of lagophthalmos and keratopathy of leprosy in PR China. (9598407)
1998
36
Association of tear lipid layer interference patterns with superficial punctate keratopathy. (9634902)
1998
37
Vortex keratopathy associated with atovaquone. (7485371)
1995
38
Pseudophakic bullous keratopathy and intraocular lens fixation. To suture or not: that is the question! (7945030)
1994
39
Climatic droplet keratopathy. (7936560)
1994
40
Climatic droplet keratopathy, exfoliation syndrome, and cataract. (1768663)
1991
41
The dilemma of pseudophakic bullous keratopathy. (2674810)
1989
42
Late development of localized band keratopathy in relation to a Molteno tube. (2743783)
1989
43
Results of penetrating keratoplasty for pseudophakic bullous keratopathy with the exchange of an intraocular lens. (2804025)
1989
44
The bandage lens in bullous keratopathy. (2594381)
1989
45
Intraocular lens replacement in pseudophakic bullous keratopathy. (3901432)
1985
46
Visual acuity, refractive error, and astigmatism following corneal transplantation for pseudophakic bullous keratopathy. (3909036)
1985
47
Band keratopathy in hypercalcemia of myeloma. (7074461)
1982
48
X-linked recessive ocular dystrophy with band keratopathy. (7258937)
1981
49
Endothelial degeneration and posterior collagenous proliferation in aphakic bullous keratopathy. (306751)
1978
50
Bullous keratopathy (Fuchs' endothelial dystrophy) treated systemically with 4-trans-amino-cyclohexano-carboxylic acid. (302548)
1977

Variations for Keratopathy

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Expression for genes affiliated with Keratopathy

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Search GEO for disease gene expression data for Keratopathy.

Pathways for genes affiliated with Keratopathy

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Compounds for genes affiliated with Keratopathy

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Compounds related to Keratopathy according to GeneCards Suite gene sharing:

(show all 44)
idCompoundScoreTop Affiliating Genes
1uric acid43 2410.8SOD3, TGFB2
2manganese superoxide439.7IL1A, SOD3
3neopterin439.6IL1A, TGFB2
4p003439.6TGFB2, TNC
5neurocan439.6DCN, TNC
6titanium439.6DCN, TNC
7alginate439.5DCN, TGFB2
8hydroxyproline43 24 1211.4FBN1, DCN
9hydrocortisone43 2 59 1212.4IL1A, TGFB2
101,25 dihydroxy vitamin d3439.3IL1A, TGFB2
11homocysteine43 2410.3SOD3, FBN1
12h2o2439.2IL1A, SOD3, TNC
13cycloheximide439.2TNC, TGFB2, IL1A
14carboplatin43 49 1211.1IL1A, DCN
15matrigel439.1TGFB2, DCN, TNC
16chondroitin sulfate43 2410.1FBN1, TNC, DCN
17paraffin439.1TGFB2, DCN, TNC
18procollagen439.0IL1A, DCN, TNC
19ribonucleic acid438.9DCN, TGFB2, IL1A
20vitamin d438.9FBN1, TGFB2, SOD3, IL1A
21sodium dodecylsulfate438.9IL1A, DCN, FBN1
22genistein43 28 59 2 24 1213.9DCN, TGFB2, IL1A
23cyclosporin a43 28 5910.9IL1A, TGFB2, DCN
24pge2438.9IL1A, TGFB2, DCN
25oligonucleotide438.9TNC, DCN, TGFB2
26progesterone43 28 59 24 1212.8FBN1, TNC, TGFB2, IL1A
27heparan sulfate43 249.8SOD3, DCN, TNC, FBN1
28aspartate438.8SLC4A4, IL1A, DCN
29tgf beta1438.7FBN1, TNC, DCN, TGFB2
30estrogen438.6FBN1, TNC, DCN, TGFB2
31glycosaminoglycan438.6IL1A, TGFB2, DCN, TNC
32nitric oxide43 24 1210.6DCN, TGFB2, SOD3, IL1A
33creatinine438.6TNC, DCN, TGFB2, IL1A
34dexamethasone43 49 28 1211.5TNC, DCN, TGFB2, IL1A
35ascorbic acid43 249.5FBN1, TNC, TGFB2, SOD3, IL1A
36arginine438.5FBN1, DCN, SOD3, IL1A
37cysteine438.3FBN1, TNC, DCN, TGFB2, SOD3
38vegf438.2TNC, DCN, TGFB2, SOD3, IL1A
39tyrosine438.1SLC4A4, TGFB2, DCN, TNC, FBN1
40hyaluronic acid43 249.1IL1A, TGFB2, DCN, TNC, FBN1
41retinoic acid43 249.1IL1A, TGFB2, DCN, TNC, FBN1
42heparin43 28 24 1210.7FBN1, TNC, DCN, TGFB2, SOD3, IL1A
43serine437.7FBN1, TNC, DCN, TGFB2, SOD3, IL1A
44glutamate437.6FBN1, TNC, DCN, TGFB2, IL1A, SLC4A4

GO Terms for genes affiliated with Keratopathy

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Cellular components related to Keratopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00057969.3SOD3, DCN
2basement membraneGO:00056049.2TNC, FBN1
3extracellular matrixGO:00310128.0SOD3, TGFB2, DCN, TNC, FBN1
4extracellular spaceGO:00056157.3FBN1, TNC, DCN, TGFB2, SOD3, IL1A
5extracellular regionGO:00055767.2FBN1, TNC, DCN, TGFB2, SOD3, IL1A

Biological processes related to Keratopathy according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to woundingGO:00096119.6TGFB2, TNC
2response to copper ionGO:00466889.6IL1A, SOD3
3positive regulation of cell divisionGO:00517819.5TGFB2, IL1A
4response to mechanical stimulusGO:00096129.1DCN, TNC
5extracellular matrix disassemblyGO:00226179.1DCN, FBN1
6wound healingGO:00420608.9TNC, DCN, TGFB2
7kidney developmentGO:00018228.8DCN, FBN1
8extracellular matrix organizationGO:00301988.4TGFB2, DCN, TNC, FBN1

Molecular functions related to Keratopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:00055079.5IL1A, SOD3

Products for genes affiliated with Keratopathy

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Sources for Keratopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet