MCID: KRT008
MIFTS: 44

Keratopathy malady

Category: Eye diseases

Aliases & Classifications for Keratopathy

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Aliases & Descriptions for Keratopathy:

Name: Keratopathy 35 11 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:2283
NCIt45 C27012

Summaries for Keratopathy

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MalaCards based summary: Keratopathy is related to limbal stem cell deficiency and bullous keratopathy. An important gene associated with Keratopathy is PAX6 (Paired Box 6), and among its related pathways are Amplification and Expansion of Oncogenic Pathways as Metastatic Traits and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include endothelial, eye and t cells, and related mouse phenotypes are renal/urinary system and normal.

Related Diseases for Keratopathy

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Diseases related to Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1limbal stem cell deficiency26.8AIRE, AKR1B1, BMP4, FBN1, IGF1, IL1A
2bullous keratopathy12.4
3band keratopathy12.3
4neurotrophic keratopathy11.9
5corneal intraepithelial dyskeratosis and ectodermal dysplasia10.8
6endotheliitis10.3
7renovascular hypertension10.1IL1A, VCAM1
8neuropathy, hereditary sensory and autonomic, type vi10.1BMP4, FBN1
9keratitis10.1
10hypotrichosis 410.1AIRE, IL1A
11drug psychosis10.1IL1A, TAC1
12ring dermoid of cornea10.0BMP4, PAX6
13aniridia10.0
14cataract10.0
15aortic aneurysm, familial thoracic 610.0IL1A, TNC, VCAM1
16lacrimal duct obstruction9.9IGF1, PAX6
17lymphedema9.9IL1A, KRT12, VCAM1
18lagophthalmos9.9
19multiple myeloma9.9
20keratoconus9.9
21contact lens corneal edema9.8BMP4, FBN1, IL1A, NID1, TNC
22fuchs' endothelial dystrophy9.8
23thymus adenosquamous carcinoma9.8IGF1, IL1A, PAX6
24citrullinemia, type ii, neonatal-onset9.8AKR1B1, IGF1, VCAM1
25stomach carcinoma in situ9.8IGF1, IL1A
26herpes zoster9.8
27corneal disease9.7
28herpes simplex9.7
29leprosy9.6
30insulin-like growth factor i9.6
31kawasaki disease9.6
32fabry disease9.6
33arthritis9.6
34crohn's disease9.6
35lymphoma9.6
36ptosis9.6
37xerophthalmia9.6
38cystinosis9.6
39keratomalacia9.6
40corneal neovascularization9.6
41choroiditis9.6
42corneal deposit9.6
43astigmatism9.6
44myopia9.6
45corneal degeneration9.6
46uveitis9.6
47scleritis9.6
48hyperparathyroidism9.6
49melanoma9.6
50strabismus9.6

Graphical network of the top 20 diseases related to Keratopathy:



Diseases related to keratopathy

Symptoms & Phenotypes for Keratopathy

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MGI Mouse Phenotypes related to Keratopathy according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.8AKR1B1, BMP4, FBN1, IGF1, PAX6, TAC1
2MP:00028738.7AIRE, BMP4, IGF1, KRT12, PAX6, TAC1
3MP:00030128.5AIRE, BMP4, FBN1, KRT12, TNC, VCAM1
4MP:00107718.5BMP4, FBN1, IGF1, IL1A, PAX6, TAC1
5MP:00053918.3AIRE, AKR1B1, BMP4, KRT12, NID1, PAX6
6MP:00053868.2AIRE, AKR1B1, BMP4, FBN1, NID1, PAX6
7MP:00053857.6BMP4, FBN1, IGF1, IL1A, NID1, PAX6
8MP:00053767.0AIRE, AKR1B1, BMP4, FBN1, IGF1, IL1A

Drugs & Therapeutics for Keratopathy

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Drugs for Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 89)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Pharmaceutical SolutionsPhase 4, Phase 3, Phase 2, Phase 18192
2
AcetylcholineapprovedPhase 2, Phase 380551-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
3Neuromuscular AgentsPhase 2, Phase 31180
4Neurotransmitter AgentsPhase 2, Phase 318340
5Peripheral Nervous System AgentsPhase 2, Phase 3, Phase 123689
6incobotulinumtoxinAPhase 2, Phase 3662
7onabotulinumtoxinAPhase 2, Phase 3652
8Botulinum ToxinsPhase 2, Phase 3697
9abobotulinumtoxinAPhase 2, Phase 3652
10Botulinum Toxins, Type APhase 2, Phase 3657
11Cholinergic AgentsPhase 2, Phase 33992
12TetrahydrozolinePhase 3, Phase 1, Phase 2621
13Ophthalmic SolutionsPhase 3, Phase 1, Phase 21140
14
Bevacizumabapproved, investigationalPhase 22020216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
15
Methylprednisoloneapproved, vet_approvedPhase 2119383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
16
Prednisoloneapproved, vet_approvedPhase 2119350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
 
MLS001304083
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
17
EphedrineapprovedPhase 1, Phase 2628299-42-39294
Synonyms:
( )-Pseudoephedrine
(+)-Ephedrin
(+)-Ephedrine
(+)-Pseudoephedrine
(+)-psi-Ephedrine
(+)-threo-Ephedrine
(+-)-Ephedrine
(-)-Ephedrine
(-)-Pseudoephedrine
(-)-psi-Ephedrine
(-)-threo-Ephedrine
(1R,2R)-Ephedrine
(1R,2S)-1-Phenyl-1-hydroxy-2-methylaminopropane
(1S,2R)-Ephedrine
(L)-EPHEDRINE
--EPHEDRINE
1-EPHEDRINE
1-Sedrin
134910_ALDRICH
287636_ALDRICH
287644_ALDRICH
299-42-3
304-87-0
30987-59-8
321-96-0
321-97-1
321-98-2
37577-31-4
38732-95-5
45261_FLUKA
4607-45-8
50-98-6
50906-05-3
53214-57-6
649031_ALDRICH
6912-63-6
7009-81-6
90-82-4
968-63-8
AC-20231
AC-20292
AC1L1JGK
AC1L1NUA
AC1L1RFA
AC1L1SR1
AC1L1T31
AC1L1Y3M
AC1O8JUO
AC1Q3XJE
AC1Q3XJM
AC1Q3XJN
AC1Q59F5
AC1Q7701
AI3-02761
AKOS000268842
AR-1A0126
AR-1I7143
Acunaso
Acunaso (TN)
Afrinol
Ambap299-42-3
BIDD:GT0817
BRN 3197916
BRN 4231286
BSPBio_001946
BSPBio_001968
BSPBio_003261
Benylin Decongestant
Besan
Biophedrin
C01575
C02765
C10H15NO
CHEBI:15407
CHEBI:51209
CHEMBL1590
CHEMBL211456
CHEMBL357080
CID11972440
CID5032
CID62946
CID6710657
CID7028
CID8650
CID9294
CID9457
CPD-9954
CPDD 0049
Cenafed
D00124
D08449
DB00852
DB01364
Decofed
DivK1c_000181
DivK1c_000451
DivK1c_000461
Drixoral N.D.
EINECS 202-017-0
EINECS 202-018-6
EINECS 206-080-5
EINECS 206-292-8
EINECS 206-293-3
Eciphin
Efedrin
Efidac/24
Eltor 120
Ephedral
Ephedremal
Ephedrin
Ephedrine
Ephedrine (TN)
Ephedrine (USP)
Ephedrine [USAN:BAN]
Ephedrine l-form
Ephedrital
Ephedrol
Ephedrosan
Ephedrotal
Ephedsol
Ephendronal
Ephoxamin
Fedrin
Genaphed
HSDB 3072
HSDB 3177
I-Sedrin
I01-3584
I01-8925
I01-8928
 
IDI1_000181
IDI1_000451
IDI1_000461
Isoephedrine
Jsp005664
KBio1_000181
KBio1_000451
KBio1_000461
KBio2_001358
KBio2_001500
KBio2_003926
KBio2_004068
KBio2_006494
KBio2_006636
KBio3_001188
KBio3_001446
KBio3_002762
KBioGR_001013
KBioGR_001763
KBioSS_001358
KBioSS_001500
KST-1A9168
Kratedyn
L(+)-psi-Ephedrine
L(-)-Ephedrine
L-(+)-Ephedrine
L-(-)-Ephedrine
L-Ephedrine
L-erythro-2-(Methylamino)-1-phenylpropan-1-ol
L000968
LS-125921
LS-125922
LS-43083
LS-63961
LS-63962
LS-63963
LS-63964
Lexofedrin
Lopac-E-3250
Lopac0_000501
MLS000069657
Manadrin
Mandrin
Maxenal
MolPort-001-684-474
MolPort-001-684-477
MolPort-001-684-478
MolPort-001-684-479
MolPort-001-769-085
Myfedrine
NCGC00015408-01
NCGC00015408-02
NCGC00162174-01
NCGC00178180-01
NCGC00178889-01
NCI-C55652
NCI60_002955
NINDS_000181
NINDS_000451
NINDS_000461
NSC 165609
NSC 170951
NSC 8971
NSC165609
NSC170951
NSC8971
Nasol
Neodurasina
Neodurasina (TN)
Oprea1_287330
PDSP1_000168
PDSP1_001106
PDSP1_001343
PDSP1_001345
PDSP1_001346
PDSP1_001347
PDSP2_000167
PDSP2_001090
PDSP2_001327
PDSP2_001329
PDSP2_001330
PDSP2_001331
PSEUDOEPHEDRINE
Pedia Care
Pseudo
Pseudo 60's
Pseudo-12
Pseudoefedrina
Pseudoephedrine (D)
Pseudoephedrinum
Psi-ephedrin
Psi-ephedrine
Robidrine
SMR000059174
SPBio_000214
SPBio_001365
SPBio_001377
ST023802
STK367993
STOCK1N-42675
Sanedrine
Spectrum2_000137
Spectrum2_001303
Spectrum2_001309
Spectrum3_000414
Spectrum3_000563
Spectrum3_001771
Spectrum4_000497
Spectrum4_001162
Spectrum5_000650
Spectrum5_000879
Spectrum5_001106
Spectrum_000878
Spectrum_001020
Sudafed
Sudafed Decongestant
UNII-03VRY66076
UNII-7CUC9DDI9F
UNII-GN83C131XS
Vencipon
WLN: QYR & Y1 & M1
WLN: QYR&Y1&M1
Zephrol
d-Ephedrine
d-Isoephedrine
d-Pseudoephedrine
d-psi-Ephedrine
l-Ephedrine
l-Pseudoephedrine
racephedrine
trans-Ephedrine
18
AmbroxolapprovedPhase 1, Phase 21518683-91-5
Synonyms:
Ambroxolum
Bisolvon metabolite vIII
Bromhexine metabolite vIII
Bromhexine-metabolite vIII
 
N-(2-Amino-3,4-dibromociclohexil)-trans-4-aminociclohexanol
N-(2-Amino-3,4-dibromocyclohexyl)-trans-4-aminocyclohexanol
trans-4-((2-Amino-3,5-dibromobencil)amino)ciclohexanol
trans-4-((2-Amino-3,5-dibromobenzyl)amine)cyclohexanol
trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol
19
FluorometholoneapprovedPhase 220426-13-19878
Synonyms:
(1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11beta,17alpha-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione
426-13-1
9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11-beta,17-dihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
AC-3520
AC1L1U0Y
AI3-52813
Alcon Brand of Fluorometholone
Allergan Brand 1 of Fluorometholone
Allergan Brand 2 of Fluorometholone
Allergan Brand 3 of Fluorometholone
BPBio1_001029
BRD-K64862097-001-03-9
BSPBio_000935
CHEMBL1200600
CID9878
Cortilet
Cortisdin
D005469
D01367
DB00324
Delmeson
EINECS 207-041-5
Efflumidex
F0414
F9381_SIGMA
FML
FML Forte
FML Liquifilm
FML S.O.P
FML-S Liquifilm
Fluaton
Flucon
Flucon, Isopto
Flumetholon
Fluor Op
Fluor-OP
Fluor-Op
Fluor-op (TN)
Fluormetholon
Fluormetholone
Fluormetholonum
Fluoro Ophtal
Fluoro-Ophtal
Fluoromethalone
Fluorometholon
Fluorometholone
 
Fluorometholone (JP15/USP/INN)
Fluorometholone [INN:BAN:JAN]
Fluorometholonum
Fluorometholonum [INN-Latin]
Fluorometolona
Fluorometolona [INN-Spanish]
Fluorometolone
Fluorometolone [DCIT]
Fluorométholone
Fluoropos
Fml (TN)
HMS1570O17
Isdin Brand of Fluorometholone
Isopto Flucon
LS-118455
Loticort
MLS000069537
MLS001076157
MolPort-003-941-413
NCGC00021575-03
NCI60_002886
NSC 33001
NSC-33001
NSC33001
Neo-Oxylone
Novartis Brand of Fluorometholone
Oxylone
Oxylone (TN)
PMS Fluorometholone
PMS-Fluorometholone
Pharm Allergan Brand of Fluorometholone
Pharm-Allergan Brand of Fluorometholone
Pharmascience Brand of Fluorometholone
Pregna-1,4-diene-3,20-dione, 9-fluoro-11.beta.,17
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17-dihydroxy-6alpha-methyl- (8CI)
Prestwick0_000718
Prestwick1_000718
Prestwick2_000718
Prestwick3_000718
Prestwick_227
SMR000058598
SPBio_002856
Trilcin
U 8614
UNII-SV0CSG527L
Ursapharm Brand of Fluorometholone
Ursnon
Winzer Brand of Fluorometholone
ZINC03876158
component of Neo-Oxylone
fluorometholone
20
PseudoephedrineapprovedPhase 1, Phase 262890-82-47028
Synonyms:
( )-Pseudoephedrine
(+) threo-2-(methylamino)-1-phenyl-1-propanol
(+)-(1S,2S)-Pseudoephedrine
(+)-Pseudoephedrine
(+)-psi-Ephedrine
(+)-threo-Ephedrine
(1S,2S)-(+)-Pseudoephedrine
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol
(1S,2S)-2-Methylamino-1-phenyl-1-propanol
(1S,2S)-Pseudoephedrine
(1S,2S)-Pseudoephedrine, polymer-bound
1-Ephedrine
2-(Methylamino)-1-phenyl-1-propanol
287636_ALDRICH
304-87-0
30987-59-8
37577-31-4
649031_ALDRICH
90-82-4
AC-20292
AC1L1NUA
Acunaso
Acunaso (TN)
Afrinol
BIDD:GT0817
BRD-K84175871-003-02-2
BSPBio_003261
Balminil Decongestant Syrup
Benylin Decongestant
Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alpha-S)- (9CI)
Besan
C02765
C10H15NO
CHEBI:51209
CHEMBL1590
CID7028
CPD-9954
Cenafed
D-Isoephedrine
D-Pseudoephedrine
D-Pseudoephedrine base
D-Psi-2-Methylamino-1-phenyl-1-propanol
D-Psi-Ephedrine
D08449
DB00852
Decofed
Dimetapp Decongestant
Dimetapp Decongestant Pediatric Drops
DivK1c_000451
Drixoral N.D.
Drixoral Nasal Decongestant
EINECS 202-018-6
Efidac 24 Pseudoephedrine Hcl
Efidac/24
Eltor 120
Ephedrine
Genaphed
HSDB 3177
I01-8928
IDI1_000451
Isoephedrine
KBio1_000451
 
KBio2_001358
KBio2_003926
KBio2_006494
KBio3_002762
KBioGR_001763
KBioSS_001358
L(+)-Psi-Ephedrine
L(+)-psi-Ephedrine
L-(+)-Pseudoephedrine
LS-125922
Lopac-E-3250
Maxenal
MolPort-001-684-474
Myfedrine
NCGC00015408-01
NCGC00178180-01
NCI60_002955
NINDS_000451
Neodurasina
Neodurasina (TN)
Novafed
PDSP1_001347
PSEUDOEPHEDRINE
Pedia Care
Pseudo
Pseudo 60's
Pseudo-12
Pseudoefedrina
Pseudoefedrina [INN-Spanish]
Pseudoephedrine
Pseudoephedrine (D)
Pseudoephedrine (INN)
Pseudoephedrine D-form
Pseudoephedrine Ephedrine
Pseudoephedrine [INN:BAN]
Pseudoephedrine d-form
Pseudoephedrinum
Pseudoephedrinum [INN-Latin]
Psi-ephedrin
Psi-ephedrine
Robidrine
SPBio_001365
STOCK1N-42675
Spectrum2_001303
Spectrum3_001771
Spectrum4_001162
Spectrum5_000650
Spectrum_000878
Sudafed
Sudafed Decongestant
Sudafed Decongestant 12 Hour
Sudafed Decongestant Extra Strength
Triaminic AM Decongestant Formula
Triaminic Infant Oral Decongestant Drops
UNII-7CUC9DDI9F
alpha-(1-(Methylamino)ethyl)benzyl alcohol
d-Isoephedrine
d-Pseudoephedrine
d-psi-2-Methylamino-1-phenyl-1-propanol
d-psi-Ephedrine
pseudoéphédrine
trans-Ephedrine
ψ-ephedrine
21MitogensPhase 21617
22AntibodiesPhase 26394
23Endothelial Growth FactorsPhase 2382
24Antibodies, MonoclonalPhase 24039
25Angiogenesis Modulating AgentsPhase 24185
26ImmunoglobulinsPhase 26394
27Angiogenesis InhibitorsPhase 24257
28ExpectorantsPhase 1, Phase 2404
29Prednisolone acetatePhase 21193
30Anti-Infective AgentsPhase 1, Phase 222062
31Prednisolone hemisuccinatePhase 21193
32Protective AgentsPhase 27443
33Vasoconstrictor AgentsPhase 1, Phase 22122
34Nasal DecongestantsPhase 1, Phase 2598
35Respiratory System AgentsPhase 1, Phase 24997
36Prednisolone phosphatePhase 21193
37Neuroprotective AgentsPhase 21716
38Anti-Inflammatory AgentsPhase 210729
39Antineoplastic Agents, HormonalPhase 25592
40AntiemeticsPhase 24022
41Anti-Allergic AgentsPhase 21522
42AnestheticsPhase 29596
43Methylprednisolone HemisuccinatePhase 21193
44Autonomic AgentsPhase 2, Phase 110150
45Gastrointestinal AgentsPhase 28402
46Methylprednisolone acetatePhase 21193
47HormonesPhase 214415
48Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 213168
49Hormone AntagonistsPhase 213180
50glucocorticoidsPhase 25103

Interventional clinical trials:

(show all 37)
idNameStatusNCT IDPhase
1Study of the Presence and Extent of Corneal Disturbance Associated With B+L Biotrue MPS Used With B+L PureVision LensesCompletedNCT01268306Phase 4
2Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye DiseaseUnknown statusNCT00370734Phase 2, Phase 3
3Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1RecruitingNCT02600429Phase 3
4Stem Cells Treatment for Bilateral Limbic Associated Keratopathy (HULPOFT)Unknown statusNCT01808378Phase 2
5Bevacizumab for the Treatment of Corneal NeovascularizationUnknown statusNCT00992849Phase 2
6Amniotic Membrane Graft In Syntomathic Bullous KeratopathyCompletedNCT01926535Phase 2
7Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK)CompletedNCT01448213Phase 2
8Utilization of Amniotic Membrane Extract Eye Drop (AMEED) on Human Corneal HealingCompletedNCT02746848Phase 1, Phase 2
9Effects of Oral Mucolytics on Tear Film and Ocular SurfaceCompletedNCT01713179Phase 1, Phase 2
10A Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic KeratopathyRecruitingNCT03084861Phase 1, Phase 2
11Study Evaluating Efficacy and Safety of SAR566658 Treatment in Patients With CA6 Positive Metastatic Triple Negative Breast CancerRecruitingNCT02984683Phase 2
12Study of Ataluren in Patients With AniridiaRecruitingNCT02647359Phase 2
13Pain and Visual Outcome in Intravitreal Bevacizumab InjectionEnrolling by invitationNCT02790775Phase 2
14A Randomized, Controlled, Double-Masked, Clinical Trial of Autologous Serum Eye Drops for Severe Ocular Chronic Graft-versus-Host Disease (GVHD) in Hematopoietic Stem Cell Transplant (HSCT) PatientsTerminatedNCT01972438Phase 2
15A Study of SAR428926 in Patients With Advanced Solid TumorsRecruitingNCT02575781Phase 1
16Assessment of Any Potential Retinal Effects of Tafenoquine (TQ)Active, not recruitingNCT02658435Phase 1
17Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture MediaUnknown statusNCT00623584
18Comparing Endoglide to Endoserter for DSAEK Graft InsertionUnknown statusNCT01791075
19Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal EdemaUnknown statusNCT01890252
20Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)Unknown statusNCT02020044
21Amniotic Membrane and Anterior Stromal Puncture to the Treatment of Symptomatic Bullous KeratopathyCompletedNCT00659308
22The Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking on the Signs and Symptoms of Bullous KeratopathyCompletedNCT01106274
23Automated Lamellar Keratectomy in Symptomatic Patients With Bullous KeratopathyCompletedNCT00654888
24The SNEC DSAEK EndoGlide Clinical TrialCompletedNCT01122043
25Eyelash Line Resection for Entropion Associated With Down's SyndromeCompletedNCT01758718
26A Comparison of Hydrogel Dressings and Ocular Lubricants in the Prevention on Corneal Damage in the Critically IllCompletedNCT00513734
27Safety and Effectiveness of Subconjunctival Injection of Bevacizumab in the Treatment of Corneal NeovasculizationCompletedNCT00681603
28Comparison of Patient Comfort After Two Anesthetic Protocols for Injections Into the EyeCompletedNCT01087489
29Long-term Topical Cyclosporine for Atopic KeratoconjunctivitisCompletedNCT00987467
30Correlation of Gene Abnormalities and Clinical Manifestations of AniridiaCompletedNCT00265590
31Blood Based Eyedrops From Different Sources in the Treatment of Severe KeratopathyRecruitingNCT03064984
32Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal EdemaRecruitingNCT02660151
33Staged and Combined Surgery for Cataract Patients With Corneal Endothelial DysfunctionRecruitingNCT02523950
34Study of Endothelial Keratoplasty OutcomesRecruitingNCT00800111
35Corneal Transplantation Guided by OCT RESCANNot yet recruitingNCT02736877
36Comparison of Aqueous and Plasma Glucose Level in Diabetic PatientsNot yet recruitingNCT02750098
37Topical Steroid Treatment After Posterior Lamellar Corneal TransplantationWithdrawnNCT01682421

Search NIH Clinical Center for Keratopathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Keratopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Keratopathy:
Adipose-derived stem cells for treatment of bilateral limbic-associated keratopathy
Embryonic/Adult Cultured Cells Related to Keratopathy:
Adipose-derived stem cells

Genetic Tests for Keratopathy

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Anatomical Context for Keratopathy

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MalaCards organs/tissues related to Keratopathy:

36
Endothelial, Eye, T cells, B cells, Myeloid, Testes, Brain

Publications for Keratopathy

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Articles related to Keratopathy:

(show top 50)    (show all 727)
idTitleAuthorsYear
1
Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma. (28079685)
2017
2
In vivo confocal microscopy of toxic keratopathy. (27740620)
2017
3
Refractory Tamoxifen-Induced Keratopathy Despite Drug Withdrawal. (27918356)
2016
4
Prosthetic Replacement of the Ocular Surface Ecosystem Scleral Lens Therapy for Exposure Keratopathy. (27171131)
2016
5
Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells. (27077448)
2016
6
Tegaderm(TM)dressing and Lacri-lube ointment moisture chamber to manage exposure keratopathy. (27769340)
2016
7
Descemet Stripping Automated Endothelial Keratoplasty in Fuchs' Endothelial Dystrophy versus Pseudophakic Bullous Keratopathy. (27994806)
2016
8
The benefit of preventing exposure keratopathy in icu patient: a case report. (27217884)
2016
9
Thymosin Beta 4: A Potential Novel Therapy for Neurotrophic Keratopathy, Dry Eye, and Ocular Surface Diseases. (27450739)
2016
10
Non-Descemet Stripping Automated Endothelial Keratoplasty for Bullous Keratopathy in Buphthalmic Eye. (27462256)
2016
11
Toxic Keratopathy Following the Use of Alcohol-Containing Antiseptics in Nonocular Surgery. (26913777)
2016
12
Crystalline keratopathy due to intravenous immunoglobulin in a 12-year-old girl with Kawasaki disease. (27667371)
2016
13
Post-septal upper eyelid loading for treatment of exposure keratopathy secondary to non-cicatricial lagophthalmos. (27541938)
2016
14
Comparison of Long-term Clinical Outcomes between Descemet's Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty in Patients with Bullous Keratopathy. (27980363)
2016
15
Neurotrophic keratopathy secondary to trigeminal nerve aplasia in patient with Goldenhar syndrome. (26819096)
2016
16
Corneal Collagen Cross Linking (CXL) in treatment of Pseudophakic Bullous Keratopathy. (27648049)
2016
17
Five-Year PROSE Treatment for Aniridic Keratopathy. (27668496)
2016
18
Pharmacologic Management of Pressure-Induced Stromal Keratopathy after LASIK. (27003814)
2016
19
Keratopathy due to ophthalmic drug abuse with corneal melting and perforation presenting as Mooren-like ulcer: A case report. (27347060)
2016
20
Infectious crystalline keratopathy caused by Cladosporium sp. after penetrating keratoplasty: a case report. (27621671)
2016
21
The Hematologic Definition of Monoclonal Gammopathy of Undetermined Significance in Relation to Paraproteinemic Keratopathy (An American Ophthalmological Society Thesis). (28050052)
2016
22
Superficial Keratectomy and Conjunctival Advancement Hood Flap (SKCAHF) for the Management of Bullous Keratopathy: Validation in Dogs With Spontaneous Disease. (27538190)
2016
23
Paraproteinemic Keratopathy as the Presenting Sign of Hematologic Malignancy. (26872417)
2016
24
Anterior segment optical coherence tomography of silicone oil keratopathy. (27558194)
2016
25
Infectious crystalline keratopathy in dogs and cats: clinical, in vivo confocal microscopic, histopathologic, and microbiologic features of eight cases. (27352988)
2016
26
Comparison of corneal degeneration and calcific band keratopathy from 2000 to 2013 in 69 horses. (26773714)
2016
27
An association between systemic cyclosporine administration and development of acute bullous keratopathy in cats. (26880480)
2016
28
Corneal Tattooing and Anterior Stromal Puncture for Treating Symptomatic Bullous Keratopathy. (26606297)
2016
29
Elevated Cytokine Levels in the Aqueous Humor of Eyes With Bullous Keratopathy and Low Endothelial Cell Density. (27820951)
2016
30
Risk of Band Keratopathy in Patients with End-Stage Renal Disease. (27346848)
2016
31
LASIK Interface Complications: Pressure-induced Stromal Keratitis (PISK), Interface Fluid Syndrome (IFS) and Post-LASIK Edema-induced Keratopathy (PLEK). (27257731)
2016
32
Dendritiform Keratopathy Associated with Exposure to Polyquarternium-1, a Common Ophthalmic Preservative. (26686962)
2016
33
Optical coherence tomography of band keratopathy. (28039348)
2016
34
Effects of diabetic keratopathy on corneal optical density, central corneal thickness, and corneal endothelial cell counts. (27588090)
2016
35
Bilateral central toxic keratopathy after laser in situ keratomileusis. (26621902)
2015
36
Long-term symptomatic relief of bullous keratopathy with amniotic membrane transplant. (25586624)
2015
37
Prevalence of Punctate Keratopathy of West Indians in a Colombian Referral Center and a New Name Proposed: RiceA's Keratopathy. (25713637)
2015
38
Climatic droplet keratopathy: an old disease in new clothes. (25626588)
2015
39
The use of endoillumination probe-assisted Descemet membrane endothelial keratoplasty for bullous keratopathy secondary to argon laser iridotomy. (25609910)
2015
40
Targeting growth factor supply in keratopathy treatment: comparison between maternal peripheral blood and cord blood as sources for the preparation of topical eye drops. (26192781)
2015
41
Toxic keratopathy associated with abuse of topical anesthetics and amniotic membrane transplantation for treatment. (26558205)
2015
42
Erlotinib-related keratopathy in a patient underwent laser in situ keratomileusis. (26264534)
2015
43
Simultaneous Descemet's membrane endothelial keratoplasty and posterior iris-claw-fixated intra ocular lens implantation (IOL) in management of aphakic bullous keratopathy. (26286755)
2015
44
Vortex Keratopathy: Fabry Related or Amiodarone Induced? (26153877)
2015
45
Real-Time Microscope-Integrated OCT to Improve Visualization in DSAEK for Advanced Bullous Keratopathy. (26509766)
2015
46
Incidence and risk factor evaluation of exposure keratopathy in critically ill patients: a cohort study. (25468364)
2015
47
Climatic Droplet Keratopathy in Argentina: Involvement of Environmental Agents in Its Genesis Which Would Open the Prospect for New Therapeutic Interventions. (26451372)
2015
48
Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model. (26509077)
2015
49
Changes in Corneal Biomechanical Properties After Descemet Stripping Automated Endothelial Keratoplasty for Pseudophakic Bullous Keratopathy. (26555584)
2015
50
Etiologies, Quantitative Hypoesthesia, and Clinical Outcomes of Neurotrophic Keratopathy. (25828513)
2015

Variations for Keratopathy

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Expression for genes affiliated with Keratopathy

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Search GEO for disease gene expression data for Keratopathy.

GO Terms for genes affiliated with Keratopathy

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Cellular components related to Keratopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:000560410.0FBN1, NID1, TNC
2proteinaceous extracellular matrixGO:00055788.7BMP4, FBN1, NID1, TNC
3extracellular regionGO:00055767.9BMP4, FBN1, IGF1, IL1A, NID1, TAC1
4extracellular spaceGO:00056156.8AKR1B1, BMP4, FBN1, IGF1, IL1A, NID1

Biological processes related to Keratopathy according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1neuron fate commitmentGO:004866310.4BMP4, PAX6
2pituitary gland developmentGO:002198310.4BMP4, PAX6
3positive regulation of ossificationGO:004577810.4BMP4, TAC1
4negative regulation of extrinsic apoptotic signaling pathwayGO:200123710.3BMP4, IGF1
5metanephros developmentGO:000165610.2BMP4, FBN1
6renal system developmentGO:007200110.1AKR1B1, BMP4
7positive regulation of mitotic nuclear divisionGO:004584010.0IGF1, IL1A
8positive regulation of protein secretionGO:005071410.0IGF1, IL1A
9camera-type eye developmentGO:00430109.9BMP4, FBN1, PAX6
10positive regulation of smooth muscle cell proliferationGO:00486619.9AKR1B1, BMP4, IGF1
11regulation of gene expressionGO:00104689.9BMP4, IGF1, PAX6
12telencephalon regionalizationGO:00219789.7BMP4, PAX6
13positive regulation of transcription, DNA-templatedGO:00458939.6AIRE, BMP4, IGF1, PAX6
14cellular protein metabolic processGO:00442679.4BMP4, FBN1, IGF1, TNC
15extracellular matrix organizationGO:00301989.3FBN1, NID1, TNC, VCAM1
16skeletal system developmentGO:00015019.2BMP4, FBN1, IGF1
17positive regulation of gene expressionGO:00106289.2BMP4, IL1A, PAX6, TNC
18positive regulation of transcription from RNA polymerase II promoterGO:00459448.9AIRE, BMP4, IGF1, IL1A, PAX6

Molecular functions related to Keratopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:00051789.0FBN1, IGF1, VCAM1

Sources for Keratopathy

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet