MCID: KRT008
MIFTS: 50

Keratopathy malady

Eye diseases category

Summaries for Keratopathy

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66Wikipedia, 34MalaCards
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Wikipedia:66 Keratopathy can refer to: more...

MalaCards: Keratopathy is related to bullous keratopathy and cataract. An important gene associated with Keratopathy is SOD3 (superoxide dismutase 3, extracellular), and among its related pathways are Angiogenesis and Integrin cell surface interactions. The compounds uric acid and manganese superoxide have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and brain, and related mouse phenotypes are cardiovascular system and craniofacial.

Aliases & Classifications for Keratopathy

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Sources:
9Disease Ontology, 11DISEASES, 32LifeMap Discoveryā„¢, 63UMLS, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

keratopathy 9 11 32 63


External Ids:

Disease Ontology9 DOID:2283
NCIt41 C27012

Related Diseases for Keratopathy

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Keratopathy:



Diseases related to keratopathy

Symptoms for Keratopathy

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Drugs & Therapeutics for Keratopathy

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢
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Approved drugs:

Search CenterWatch for Keratopathy

Drug clinical trials:

Search ClinicalTrials for Keratopathy

Search NIH Clinical Center for Keratopathy

Search CenterWatch for Keratopathy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Keratopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Keratopathy:
Adipose-derived stem cells for treatment of bilateral limbic-associated keratopathy
Embryonic/Adult Cultured Cells Related to Keratopathy:
Adipose-derived stem cells

Genetic Tests for Keratopathy

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Anatomical Context for Keratopathy

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Sources:
34MalaCards
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MalaCards organs/tissues related to Keratopathy:

34
Endothelial, Eye, Brain, Lung, Skin, Testes, B cells

Animal Models for Keratopathy or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Keratopathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.4SLC4A4, IL1A, TGFB2, FBN1
2MP:00053828.3SLC4A4, TGFB2, DCN, FBN1
3MP:00053678.2FBN1, DCN, TGFB2, SLC4A4
4MP:00053698.1FBN1, DCN, TGFB2, SLC4A4
5MP:00053907.9FBN1, DCN, TGFB2, SOD3, SLC4A4
6MP:00053977.5SLC4A4, IL1A, TGFB2, DCN, FBN1
7MP:00107687.5FBN1, DCN, TGFB2, SOD3, SLC4A4
8MP:00053877.3FBN1, DCN, TGFB2, SOD3, IL1A, SLC4A4
9MP:00053766.9SLC4A4, FBN1, TNC, DCN, TGFB2, SOD3

Publications for Keratopathy

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53PubMed
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Articles related to Keratopathy:

(show top 50)    (show all 625)
idTitleAuthorsYear
1
Midinfrared Laser Pancorneal Coagulation as a Method of Treatment for Painful Bullous Keratopathy. (23974894)
2013
2
Treatment of bullous keratopathy with corneal collagen cross-linking in two dogs. (24373539)
2013
3
Autologous tragal perichondrium transplantation: a novel approach for the management of painful bullous keratopathy. (23730105)
2013
4
Genetic background and climatic droplet keratopathy incidence in a mapuche population from Argentina. (24040292)
2013
5
New findings for an old disease: morphological studies on pseudoexfoliation syndrome-related keratopathy and binocular asymmetry. (24104940)
2013
6
In vivo confocal microscopy study of climatic droplet keratopathy. (22538217)
2012
7
Excimer laser phototherapeutic keratectomy for the treatment of silicone oil-induced band-shaped keratopathy. (21455078)
2011
8
Long-term outcome of central toxic keratopathy after photorefractive keratectomy. (21926568)
2011
9
Reproducibility of cornea measurements in anterior segment OCT images of normal eyes and eyes with bullous keratopathy analyzed with the Zhongshan Assessment Program. (21828152)
2011
10
Confocal microscopy of contact lens keratitis presenting as central toxic keratopathy. (21808198)
2011
11
Penetrating keratoplasty for bullous keratopathy after trabeculectomy. (18369373)
2009
12
In vivo morphometry of corneal endothelial cells in pseudoexfoliation keratopathy with glaucoma and cataract. (19365152)
2009
13
Corneal collagen cross-linking in bullous keratopathy. (19714792)
2009
14
Neuroparalytic keratopathy as the first sign of a cerebral meningioma. (17894293)
2007
15
Persistent epithelial defects due to neurotrophic keratopathy treated with a substance p-derived peptide and insulin-like growth factor 1. (18158595)
2007
16
Ring keratopathy in a patient with psoriatic arthritis and ulcerative rectocolitis. (17365809)
2007
17
Therapeutic options for the management of early neurotrophic keratopathy: a case report and review. (17000411)
2006
18
Climatic droplet keratopathy in the Argentine Patagonia. (16564815)
2006
19
Anaesthetic abuse keratopathy as a manifestation of ocular Munchausen's syndrome. (16451265)
2006
20
Confocal microscopy of Thygeson's superficial punctate keratopathy. (15670099)
2005
21
Dendritic keratopathy in ocular rosacea. (15968176)
2005
22
The implications of the upregulation of ICAM-1/VCAM-1 expression of corneal fibroblasts on the pathogenesis of allergic keratopathy. (16303942)
2005
23
Infectious crystalline keratopathy histopathological characteristics. (14641273)
2003
24
Management of aniridic keratopathy with keratolimbal allograft: a limbal stem cell transplantation technique. (12511357)
2003
25
Keratopathy in congenital aniridia. (17075635)
2003
26
Epithelial infectious crystalline keratopathy. (11228305)
2001
27
Neurotrophic keratopathy. (11352446)
2001
28
Ultrastructural morphology and expression of proteoglycans, betaig-h3, tenascin-C, fibrillin-1, and fibronectin in bullous keratopathy. (11371495)
2001
29
Clinical course of hurricane keratopathy. (10684839)
2000
30
Infectious crystalline keratopathy. (10656309)
2000
31
Delayed mustard gas keratopathy: clinical findings and confocal microscopy. (10577594)
1999
32
Infectious crystalline keratopathy: a case report. (9810093)
1998
33
The current situation of lagophthalmos and keratopathy of leprosy in PR China. (9598407)
1998
34
Association of tear lipid layer interference patterns with superficial punctate keratopathy. (9634902)
1998
35
Vortex keratopathy associated with atovaquone. (7485371)
1995
36
Pseudophakic bullous keratopathy and intraocular lens fixation. To suture or not: that is the question! (7945030)
1994
37
Climatic droplet keratopathy. (7936560)
1994
38
The relationship between cataract and climatic droplet keratopathy in Mongolia. (7825419)
1994
39
Climatic droplet keratopathy, exfoliation syndrome, and cataract. (1768663)
1991
40
Band keratopathy secondary to an iris melanoma. (2019109)
1991
41
The dilemma of pseudophakic bullous keratopathy. (2674810)
1989
42
Late development of localized band keratopathy in relation to a Molteno tube. (2743783)
1989
43
Results of penetrating keratoplasty for pseudophakic bullous keratopathy with the exchange of an intraocular lens. (2804025)
1989
44
The bandage lens in bullous keratopathy. (2594381)
1989
45
Intraocular lens replacement in pseudophakic bullous keratopathy. (3901432)
1985
46
Visual acuity, refractive error, and astigmatism following corneal transplantation for pseudophakic bullous keratopathy. (3909036)
1985
47
Band keratopathy in hypercalcemia of myeloma. (7074461)
1982
48
X-linked recessive ocular dystrophy with band keratopathy. (7258937)
1981
49
Endothelial degeneration and posterior collagenous proliferation in aphakic bullous keratopathy. (306751)
1978
50
Bullous keratopathy (Fuchs' endothelial dystrophy) treated systemically with 4-trans-amino-cyclohexano-carboxylic acid. (302548)
1977

Variations for Keratopathy

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Expression for genes affiliated with Keratopathy

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratopathy

Search GEO for disease gene expression data for Keratopathy.

Pathways for genes affiliated with Keratopathy

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Sources:
51PathCards, 5Cell Signaling Technology, 56Reactome, 31KEGG, 58SinoBiological, 54QIAGEN
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Compounds for genes affiliated with Keratopathy

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 3BitterDB, 62Tocris Bioscience, 52PharmGKB, 30IUPHAR
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Compounds related to Keratopathy according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1uric acid46 2510.8SOD3, TGFB2
2manganese superoxide469.7IL1A, SOD3
3neopterin469.6IL1A, TGFB2
4p003469.6TGFB2, TNC
5neurocan469.6DCN, TNC
6titanium469.6DCN, TNC
7alginate469.5DCN, TGFB2
8hydroxyproline46 25 1211.4FBN1, DCN
9hydrocortisone46 3 62 1212.4IL1A, TGFB2
101,25 dihydroxy vitamin d3469.3IL1A, TGFB2
11homocysteine46 2510.3SOD3, FBN1
12h2o2469.2IL1A, SOD3, TNC
13cycloheximide469.2TNC, TGFB2, IL1A
14carboplatin46 52 1211.1IL1A, DCN
15matrigel469.1TGFB2, DCN, TNC
16chondroitin sulfate46 2510.1FBN1, TNC, DCN
17paraffin469.1TGFB2, DCN, TNC
18procollagen469.0IL1A, DCN, TNC
19ribonucleic acid468.9DCN, TGFB2, IL1A
20vitamin d468.9FBN1, TGFB2, SOD3, IL1A
21sodium dodecylsulfate468.9IL1A, DCN, FBN1
22genistein46 30 62 3 25 1213.9DCN, TGFB2, IL1A
23cyclosporin a46 30 6210.9IL1A, TGFB2, DCN
24pge2468.9IL1A, TGFB2, DCN
25oligonucleotide468.9TNC, DCN, TGFB2
26progesterone46 30 62 25 1212.8FBN1, TNC, TGFB2, IL1A
27heparan sulfate46 259.8SOD3, DCN, TNC, FBN1
28aspartate468.8SLC4A4, IL1A, DCN
29tgf beta1468.7FBN1, TNC, DCN, TGFB2
30estrogen468.6FBN1, TNC, DCN, TGFB2
31glycosaminoglycan468.6IL1A, TGFB2, DCN, TNC
32nitric oxide46 25 1210.6DCN, TGFB2, SOD3, IL1A
33creatinine468.6TNC, DCN, TGFB2, IL1A
34dexamethasone46 52 30 1211.5TNC, DCN, TGFB2, IL1A
35ascorbic acid46 259.5FBN1, TNC, TGFB2, SOD3, IL1A
36arginine468.5FBN1, DCN, SOD3, IL1A
37cysteine468.3FBN1, TNC, DCN, TGFB2, SOD3
38vegf468.2TNC, DCN, TGFB2, SOD3, IL1A
39tyrosine468.1SLC4A4, TGFB2, DCN, TNC, FBN1
40hyaluronic acid46 259.1IL1A, TGFB2, DCN, TNC, FBN1
41retinoic acid46 259.1IL1A, TGFB2, DCN, TNC, FBN1
42heparin46 30 25 1210.7FBN1, TNC, DCN, TGFB2, SOD3, IL1A
43serine467.7FBN1, TNC, DCN, TGFB2, SOD3, IL1A
44glutamate467.6FBN1, TNC, DCN, TGFB2, IL1A, SLC4A4

GO Terms for genes affiliated with Keratopathy

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17Gene Ontology
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Cellular components related to Keratopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.3SOD3, DCN
2basement membraneGO:0056049.2TNC, FBN1
3extracellular matrixGO:0310128.0SOD3, TGFB2, DCN, TNC, FBN1
4extracellular spaceGO:0056157.3FBN1, TNC, DCN, TGFB2, SOD3, IL1A
5extracellular regionGO:0055767.2FBN1, TNC, DCN, TGFB2, SOD3, IL1A

Biological processes related to Keratopathy according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to woundingGO:0096119.6TGFB2, TNC
2response to copper ionGO:0466889.6IL1A, SOD3
3positive regulation of cell divisionGO:0517819.5TGFB2, IL1A
4response to mechanical stimulusGO:0096129.1DCN, TNC
5extracellular matrix disassemblyGO:0226179.1DCN, FBN1
6wound healingGO:0420608.9TNC, DCN, TGFB2
7kidney developmentGO:0018228.8DCN, FBN1
8extracellular matrix organizationGO:0301988.4TGFB2, DCN, TNC, FBN1

Molecular functions related to Keratopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:0055079.5IL1A, SOD3

Products for genes affiliated with Keratopathy

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Sources for Keratopathy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet