Aliases & Classifications for Keratopathy

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Aliases & Descriptions for Keratopathy:

Name: Keratopathy 35 11 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:2283
NCIt45 C27012

Summaries for Keratopathy

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MalaCards based summary: Keratopathy is related to uveitis and bullous keratopathy, and has symptoms including corneal structural change, deposit and degeneration, corneal striae and dellen. An important gene associated with Keratopathy is PAX6 (Paired Box 6), and among its related pathways are IL-4 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and Cellular roles of Anthrax toxin. Affiliated tissues include endothelial, eye and breast, and related mouse phenotypes are Decreased viability with paclitaxel and normal.

Related Diseases for Keratopathy

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Diseases related to Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis29.0TGFB1, VCAM1
2bullous keratopathy12.4
3band keratopathy12.3
4neurotrophic keratopathy11.9
5corneal intraepithelial dyskeratosis and ectodermal dysplasia10.8
6autosomal recessive congenital methemoglobinemia10.4AIRE, NLRP1
7anal spasm10.3TAC1, TNC
8endotheliitis10.3
9genetic prion diseases10.3FBN1, TGFB1
10acromicric dysplasia10.3FBN1, TGFB1
11liver disease10.2KRT12, VCAM1
12necrotizing ulcerative gingivitis10.2IGF1, PAX6
13calpainopathy10.2TAC1, TGFB1
14orbital lymphangioma10.2TGFB1, VCAM1
15acute serous otitis media10.2FBN1, KRT12
16kleine-levin hibernation syndrome10.1FBN1, TAC1
17keratitis10.1
18shprintzen-goldberg syndrome10.1FBN1, TGFB1
19fibrosclerosis of breast10.1IGF1, TGFB1
20aniridia10.0
21cataract10.0
22osteopetrosis10.0IGF1, TGFB1
23hodgkin's lymphoma, lymphocytic-histiocytic predominance10.0FBN1, TGFB1
24diamond-blackfan anemia 310.0TGFB1, TNC, VCAM1
25lagophthalmos9.9
26multiple myeloma9.9
27keratoconus9.9
28agammaglobulinemia 69.9AKR1B1, TGFB1
29fuchs' endothelial dystrophy9.8
30nonsyndromic congenital nail disorder 29.8NID1, TAC1
31anorectal stricture9.8AKR1B1, PAX6
32herpes zoster9.8
33citrullinemia, adult-onset type ii9.7AKR1B1, IGF1, VCAM1
34corneal disease9.7
35herpes simplex9.7
36leprosy9.6
37insulin-like growth factor i9.6
38kawasaki disease9.6
39fabry disease9.6
40arthritis9.6
41crohn's disease9.6
42lymphoma9.6
43ptosis9.6
44xerophthalmia9.6
45cystinosis9.6
46keratomalacia9.6
47corneal neovascularization9.6
48choroiditis9.6
49corneal deposit9.6
50astigmatism9.6

Graphical network of the top 20 diseases related to Keratopathy:



Diseases related to keratopathy

Symptoms & Phenotypes for Keratopathy

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UMLS symptoms related to Keratopathy:


corneal structural change, deposit and degeneration, corneal striae, dellen, arcus lipoides, corneal leukoma, corneal thickening, corneal flap complication

GenomeRNAi Phenotypes related to Keratopathy according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00293-A10.5IGF1, TGFB1

MGI Mouse Phenotypes related to Keratopathy according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028739.1AIRE, IGF1, KRT12, PAX6, TAC1, TNC
2MP:00053678.7AKR1B1, FBN1, IGF1, PAX6, TAC1, TGFB1
3MP:00053918.3AIRE, AKR1B1, KRT12, NID1, PAX6, TGFB1
4MP:00053858.2FBN1, IGF1, NID1, PAX6, TAC1, TGFB1
5MP:00053867.8AIRE, AKR1B1, FBN1, NID1, PAX6, TAC1
6MP:00053767.0AIRE, AKR1B1, FBN1, IGF1, NLRP1, PAX6

Drugs & Therapeutics for Keratopathy

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Drugs for Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 87)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Pharmaceutical SolutionsPhase 4, Phase 3, Phase 2, Phase 17793
2
AcetylcholineapprovedPhase 2, Phase 377651-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
3Neuromuscular AgentsPhase 2, Phase 31129
4Neurotransmitter AgentsPhase 2, Phase 317734
5onabotulinumtoxinAPhase 2, Phase 3626
6Peripheral Nervous System AgentsPhase 2, Phase 3, Phase 122776
7incobotulinumtoxinAPhase 2, Phase 3635
8abobotulinumtoxinAPhase 2, Phase 3626
9Cholinergic AgentsPhase 2, Phase 33846
10Botulinum ToxinsPhase 2, Phase 3669
11Botulinum Toxins, Type APhase 2, Phase 3630
12TetrahydrozolinePhase 3, Phase 1, Phase 2593
13Ophthalmic SolutionsPhase 3, Phase 1, Phase 21092
14
Bevacizumabapproved, investigationalPhase 21968216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
15
PseudoephedrineapprovedPhase 1, Phase 260690-82-47028
Synonyms:
( )-Pseudoephedrine
(+) threo-2-(methylamino)-1-phenyl-1-propanol
(+)-(1S,2S)-Pseudoephedrine
(+)-Pseudoephedrine
(+)-psi-Ephedrine
(+)-threo-Ephedrine
(1S,2S)-(+)-Pseudoephedrine
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol
(1S,2S)-2-Methylamino-1-phenyl-1-propanol
(1S,2S)-Pseudoephedrine
(1S,2S)-Pseudoephedrine, polymer-bound
1-Ephedrine
2-(Methylamino)-1-phenyl-1-propanol
287636_ALDRICH
304-87-0
30987-59-8
37577-31-4
649031_ALDRICH
90-82-4
AC-20292
AC1L1NUA
Acunaso
Acunaso (TN)
Afrinol
BIDD:GT0817
BRD-K84175871-003-02-2
BSPBio_003261
Balminil Decongestant Syrup
Benylin Decongestant
Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alpha-S)- (9CI)
Besan
C02765
C10H15NO
CHEBI:51209
CHEMBL1590
CID7028
CPD-9954
Cenafed
D-Isoephedrine
D-Pseudoephedrine
D-Pseudoephedrine base
D-Psi-2-Methylamino-1-phenyl-1-propanol
D-Psi-Ephedrine
D08449
DB00852
Decofed
Dimetapp Decongestant
Dimetapp Decongestant Pediatric Drops
DivK1c_000451
Drixoral N.D.
Drixoral Nasal Decongestant
EINECS 202-018-6
Efidac 24 Pseudoephedrine Hcl
Efidac/24
Eltor 120
Ephedrine
Genaphed
HSDB 3177
I01-8928
IDI1_000451
Isoephedrine
KBio1_000451
 
KBio2_001358
KBio2_003926
KBio2_006494
KBio3_002762
KBioGR_001763
KBioSS_001358
L(+)-Psi-Ephedrine
L(+)-psi-Ephedrine
L-(+)-Pseudoephedrine
LS-125922
Lopac-E-3250
Maxenal
MolPort-001-684-474
Myfedrine
NCGC00015408-01
NCGC00178180-01
NCI60_002955
NINDS_000451
Neodurasina
Neodurasina (TN)
Novafed
PDSP1_001347
PSEUDOEPHEDRINE
Pedia Care
Pseudo
Pseudo 60's
Pseudo-12
Pseudoefedrina
Pseudoefedrina [INN-Spanish]
Pseudoephedrine
Pseudoephedrine (D)
Pseudoephedrine (INN)
Pseudoephedrine D-form
Pseudoephedrine Ephedrine
Pseudoephedrine [INN:BAN]
Pseudoephedrine d-form
Pseudoephedrinum
Pseudoephedrinum [INN-Latin]
Psi-ephedrin
Psi-ephedrine
Robidrine
SPBio_001365
STOCK1N-42675
Spectrum2_001303
Spectrum3_001771
Spectrum4_001162
Spectrum5_000650
Spectrum_000878
Sudafed
Sudafed Decongestant
Sudafed Decongestant 12 Hour
Sudafed Decongestant Extra Strength
Triaminic AM Decongestant Formula
Triaminic Infant Oral Decongestant Drops
UNII-7CUC9DDI9F
alpha-(1-(Methylamino)ethyl)benzyl alcohol
d-Isoephedrine
d-Pseudoephedrine
d-psi-2-Methylamino-1-phenyl-1-propanol
d-psi-Ephedrine
pseudoéphédrine
trans-Ephedrine
ψ-ephedrine
16
FluorometholoneapprovedPhase 219426-13-19878
Synonyms:
(1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11beta,17alpha-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione
426-13-1
9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11-beta,17-dihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
AC-3520
AC1L1U0Y
AI3-52813
Alcon Brand of Fluorometholone
Allergan Brand 1 of Fluorometholone
Allergan Brand 2 of Fluorometholone
Allergan Brand 3 of Fluorometholone
BPBio1_001029
BRD-K64862097-001-03-9
BSPBio_000935
CHEMBL1200600
CID9878
Cortilet
Cortisdin
D005469
D01367
DB00324
Delmeson
EINECS 207-041-5
Efflumidex
F0414
F9381_SIGMA
FML
FML Forte
FML Liquifilm
FML S.O.P
FML-S Liquifilm
Fluaton
Flucon
Flucon, Isopto
Flumetholon
Fluor Op
Fluor-OP
Fluor-Op
Fluor-op (TN)
Fluormetholon
Fluormetholone
Fluormetholonum
Fluoro Ophtal
Fluoro-Ophtal
Fluoromethalone
Fluorometholon
Fluorometholone
 
Fluorometholone (JP15/USP/INN)
Fluorometholone [INN:BAN:JAN]
Fluorometholonum
Fluorometholonum [INN-Latin]
Fluorometolona
Fluorometolona [INN-Spanish]
Fluorometolone
Fluorometolone [DCIT]
Fluorométholone
Fluoropos
Fml (TN)
HMS1570O17
Isdin Brand of Fluorometholone
Isopto Flucon
LS-118455
Loticort
MLS000069537
MLS001076157
MolPort-003-941-413
NCGC00021575-03
NCI60_002886
NSC 33001
NSC-33001
NSC33001
Neo-Oxylone
Novartis Brand of Fluorometholone
Oxylone
Oxylone (TN)
PMS Fluorometholone
PMS-Fluorometholone
Pharm Allergan Brand of Fluorometholone
Pharm-Allergan Brand of Fluorometholone
Pharmascience Brand of Fluorometholone
Pregna-1,4-diene-3,20-dione, 9-fluoro-11.beta.,17
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17-dihydroxy-6alpha-methyl- (8CI)
Prestwick0_000718
Prestwick1_000718
Prestwick2_000718
Prestwick3_000718
Prestwick_227
SMR000058598
SPBio_002856
Trilcin
U 8614
UNII-SV0CSG527L
Ursapharm Brand of Fluorometholone
Ursnon
Winzer Brand of Fluorometholone
ZINC03876158
component of Neo-Oxylone
fluorometholone
17
EphedrineapprovedPhase 1, Phase 2606299-42-39294
Synonyms:
( )-Pseudoephedrine
(+)-Ephedrin
(+)-Ephedrine
(+)-Pseudoephedrine
(+)-psi-Ephedrine
(+)-threo-Ephedrine
(+-)-Ephedrine
(-)-Ephedrine
(-)-Pseudoephedrine
(-)-psi-Ephedrine
(-)-threo-Ephedrine
(1R,2R)-Ephedrine
(1R,2S)-1-Phenyl-1-hydroxy-2-methylaminopropane
(1S,2R)-Ephedrine
(L)-EPHEDRINE
--EPHEDRINE
1-EPHEDRINE
1-Sedrin
134910_ALDRICH
287636_ALDRICH
287644_ALDRICH
299-42-3
304-87-0
30987-59-8
321-96-0
321-97-1
321-98-2
37577-31-4
38732-95-5
45261_FLUKA
4607-45-8
50-98-6
50906-05-3
53214-57-6
649031_ALDRICH
6912-63-6
7009-81-6
90-82-4
968-63-8
AC-20231
AC-20292
AC1L1JGK
AC1L1NUA
AC1L1RFA
AC1L1SR1
AC1L1T31
AC1L1Y3M
AC1O8JUO
AC1Q3XJE
AC1Q3XJM
AC1Q3XJN
AC1Q59F5
AC1Q7701
AI3-02761
AKOS000268842
AR-1A0126
AR-1I7143
Acunaso
Acunaso (TN)
Afrinol
Ambap299-42-3
BIDD:GT0817
BRN 3197916
BRN 4231286
BSPBio_001946
BSPBio_001968
BSPBio_003261
Benylin Decongestant
Besan
Biophedrin
C01575
C02765
C10H15NO
CHEBI:15407
CHEBI:51209
CHEMBL1590
CHEMBL211456
CHEMBL357080
CID11972440
CID5032
CID62946
CID6710657
CID7028
CID8650
CID9294
CID9457
CPD-9954
CPDD 0049
Cenafed
D00124
D08449
DB00852
DB01364
Decofed
DivK1c_000181
DivK1c_000451
DivK1c_000461
Drixoral N.D.
EINECS 202-017-0
EINECS 202-018-6
EINECS 206-080-5
EINECS 206-292-8
EINECS 206-293-3
Eciphin
Efedrin
Efidac/24
Eltor 120
Ephedral
Ephedremal
Ephedrin
Ephedrine
Ephedrine (TN)
Ephedrine (USP)
Ephedrine [USAN:BAN]
Ephedrine l-form
Ephedrital
Ephedrol
Ephedrosan
Ephedrotal
Ephedsol
Ephendronal
Ephoxamin
Fedrin
Genaphed
HSDB 3072
HSDB 3177
I-Sedrin
I01-3584
I01-8925
I01-8928
 
IDI1_000181
IDI1_000451
IDI1_000461
Isoephedrine
Jsp005664
KBio1_000181
KBio1_000451
KBio1_000461
KBio2_001358
KBio2_001500
KBio2_003926
KBio2_004068
KBio2_006494
KBio2_006636
KBio3_001188
KBio3_001446
KBio3_002762
KBioGR_001013
KBioGR_001763
KBioSS_001358
KBioSS_001500
KST-1A9168
Kratedyn
L(+)-psi-Ephedrine
L(-)-Ephedrine
L-(+)-Ephedrine
L-(-)-Ephedrine
L-Ephedrine
L-erythro-2-(Methylamino)-1-phenylpropan-1-ol
L000968
LS-125921
LS-125922
LS-43083
LS-63961
LS-63962
LS-63963
LS-63964
Lexofedrin
Lopac-E-3250
Lopac0_000501
MLS000069657
Manadrin
Mandrin
Maxenal
MolPort-001-684-474
MolPort-001-684-477
MolPort-001-684-478
MolPort-001-684-479
MolPort-001-769-085
Myfedrine
NCGC00015408-01
NCGC00015408-02
NCGC00162174-01
NCGC00178180-01
NCGC00178889-01
NCI-C55652
NCI60_002955
NINDS_000181
NINDS_000451
NINDS_000461
NSC 165609
NSC 170951
NSC 8971
NSC165609
NSC170951
NSC8971
Nasol
Neodurasina
Neodurasina (TN)
Oprea1_287330
PDSP1_000168
PDSP1_001106
PDSP1_001343
PDSP1_001345
PDSP1_001346
PDSP1_001347
PDSP2_000167
PDSP2_001090
PDSP2_001327
PDSP2_001329
PDSP2_001330
PDSP2_001331
PSEUDOEPHEDRINE
Pedia Care
Pseudo
Pseudo 60's
Pseudo-12
Pseudoefedrina
Pseudoephedrine (D)
Pseudoephedrinum
Psi-ephedrin
Psi-ephedrine
Robidrine
SMR000059174
SPBio_000214
SPBio_001365
SPBio_001377
ST023802
STK367993
STOCK1N-42675
Sanedrine
Spectrum2_000137
Spectrum2_001303
Spectrum2_001309
Spectrum3_000414
Spectrum3_000563
Spectrum3_001771
Spectrum4_000497
Spectrum4_001162
Spectrum5_000650
Spectrum5_000879
Spectrum5_001106
Spectrum_000878
Spectrum_001020
Sudafed
Sudafed Decongestant
UNII-03VRY66076
UNII-7CUC9DDI9F
UNII-GN83C131XS
Vencipon
WLN: QYR & Y1 & M1
WLN: QYR&Y1&M1
Zephrol
d-Ephedrine
d-Isoephedrine
d-Pseudoephedrine
d-psi-Ephedrine
l-Ephedrine
l-Pseudoephedrine
racephedrine
trans-Ephedrine
18
AmbroxolapprovedPhase 1, Phase 21518683-91-5
Synonyms:
Ambroxolum
Bisolvon metabolite vIII
Bromhexine metabolite vIII
Bromhexine-metabolite vIII
 
N-(2-Amino-3,4-dibromociclohexil)-trans-4-aminociclohexanol
N-(2-Amino-3,4-dibromocyclohexyl)-trans-4-aminocyclohexanol
trans-4-((2-Amino-3,5-dibromobencil)amino)ciclohexanol
trans-4-((2-Amino-3,5-dibromobenzyl)amine)cyclohexanol
trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol
19
Methylprednisoloneapproved, vet_approvedPhase 2115383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
20
Prednisoloneapproved, vet_approvedPhase 2115350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
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Alphadrol
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BPBio1_000164
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24ImmunoglobulinsPhase 26045
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26MitogensPhase 21526
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30Prednisolone acetatePhase 21153
31Respiratory System AgentsPhase 1, Phase 24818
32Neuroprotective AgentsPhase 21672
33ExpectorantsPhase 1, Phase 2388
34Vasoconstrictor AgentsPhase 1, Phase 22027
35Protective AgentsPhase 27190
36Nasal DecongestantsPhase 1, Phase 2578
37AntiemeticsPhase 23888
38Anti-Inflammatory AgentsPhase 210355
39Anti-Allergic AgentsPhase 21490
40AnestheticsPhase 29001
41Methylprednisolone HemisuccinatePhase 21153
42Antineoplastic Agents, HormonalPhase 25407
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44Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 212767
45Methylprednisolone acetatePhase 21153
46HormonesPhase 213979
47Hormone AntagonistsPhase 212778
48Gastrointestinal AgentsPhase 28109
49glucocorticoidsPhase 24920
50Anti-Infective AgentsPhase 121402

Interventional clinical trials:

(show all 35)
idNameStatusNCT IDPhase
1Study of the Presence and Extent of Corneal Disturbance Associated With B+L Biotrue MPS Used With B+L PureVision LensesCompletedNCT01268306Phase 4
2Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye DiseaseUnknown statusNCT00370734Phase 2, Phase 3
3Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1RecruitingNCT02600429Phase 3
4Stem Cells Treatment for Bilateral Limbic Associated Keratopathy (HULPOFT)Unknown statusNCT01808378Phase 2
5Bevacizumab for the Treatment of Corneal NeovascularizationUnknown statusNCT00992849Phase 2
6Amniotic Membrane Graft In Syntomathic Bullous KeratopathyCompletedNCT01926535Phase 2
7Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK)CompletedNCT01448213Phase 2
8Utilization of Amniotic Membrane Extract Eye Drop (AMEED) on Human Corneal HealingCompletedNCT02746848Phase 1, Phase 2
9Effects of Oral Mucolytics on Tear Film and Ocular SurfaceCompletedNCT01713179Phase 1, Phase 2
10Study Evaluating Efficacy and Safety of SAR566658 Treatment in Patients With CA6 Positive Metastatic Triple Negative Breast CancerRecruitingNCT02984683Phase 2
11Study of Ataluren in Patients With AniridiaRecruitingNCT02647359Phase 2
12Pain and Visual Outcome in Intravitreal Bevacizumab InjectionEnrolling by invitationNCT02790775Phase 2
13A Randomized, Controlled, Double-Masked, Clinical Trial of Autologous Serum Eye Drops for Severe Ocular Chronic Graft-versus-Host Disease (GVHD) in Hematopoietic Stem Cell Transplant (HSCT) PatientsTerminatedNCT01972438Phase 2
14A Study of SAR428926 in Patients With Advanced Solid TumorsRecruitingNCT02575781Phase 1
15Assessment of Any Potential Retinal Effects of Tafenoquine (TQ)Active, not recruitingNCT02658435Phase 1
16Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture MediaUnknown statusNCT00623584
17Comparing Endoglide to Endoserter for DSAEK Graft InsertionUnknown statusNCT01791075
18Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal EdemaUnknown statusNCT01890252
19Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)Unknown statusNCT02020044
20Amniotic Membrane and Anterior Stromal Puncture to the Treatment of Symptomatic Bullous KeratopathyCompletedNCT00659308
21The Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking on the Signs and Symptoms of Bullous KeratopathyCompletedNCT01106274
22Automated Lamellar Keratectomy in Symptomatic Patients With Bullous KeratopathyCompletedNCT00654888
23The SNEC DSAEK EndoGlide Clinical TrialCompletedNCT01122043
24Eyelash Line Resection for Entropion Associated With Down's SyndromeCompletedNCT01758718
25A Comparison of Hydrogel Dressings and Ocular Lubricants in the Prevention on Corneal Damage in the Critically IllCompletedNCT00513734
26Safety and Effectiveness of Subconjunctival Injection of Bevacizumab in the Treatment of Corneal NeovasculizationCompletedNCT00681603
27Comparison of Patient Comfort After Two Anesthetic Protocols for Injections Into the EyeCompletedNCT01087489
28Long-term Topical Cyclosporine for Atopic KeratoconjunctivitisCompletedNCT00987467
29Correlation of Gene Abnormalities and Clinical Manifestations of AniridiaCompletedNCT00265590
30Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal EdemaRecruitingNCT02660151
31Staged and Combined Surgery for Cataract Patients With Corneal Endothelial DysfunctionRecruitingNCT02523950
32Study of Endothelial Keratoplasty OutcomesRecruitingNCT00800111
33Corneal Transplantation Guided by OCT RESCANNot yet recruitingNCT02736877
34Comparison of Aqueous and Plasma Glucose Level in Diabetic PatientsNot yet recruitingNCT02750098
35Topical Steroid Treatment After Posterior Lamellar Corneal TransplantationWithdrawnNCT01682421

Search NIH Clinical Center for Keratopathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Keratopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Keratopathy:
Adipose-derived stem cells for treatment of bilateral limbic-associated keratopathy
Embryonic/Adult Cultured Cells Related to Keratopathy:
Adipose-derived stem cells

Genetic Tests for Keratopathy

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Anatomical Context for Keratopathy

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MalaCards organs/tissues related to Keratopathy:

36
Endothelial, Eye, Breast, Thyroid, T cells, B cells, Myeloid

Publications for Keratopathy

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Articles related to Keratopathy:

(show top 50)    (show all 727)
idTitleAuthorsYear
1
Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma. (28079685)
2017
2
In vivo confocal microscopy of toxic keratopathy. (27740620)
2017
3
Elevated Cytokine Levels in the Aqueous Humor of Eyes With Bullous Keratopathy and Low Endothelial Cell Density. (27820951)
2016
4
Risk of Band Keratopathy in Patients with End-Stage Renal Disease. (27346848)
2016
5
The Hematologic Definition of Monoclonal Gammopathy of Undetermined Significance in Relation to Paraproteinemic Keratopathy (An American Ophthalmological Society Thesis). (28050052)
2016
6
Paraproteinemic Keratopathy as the Presenting Sign of Hematologic Malignancy. (26872417)
2016
7
LASIK Interface Complications: Pressure-induced Stromal Keratitis (PISK), Interface Fluid Syndrome (IFS) and Post-LASIK Edema-induced Keratopathy (PLEK). (27257731)
2016
8
Effects of diabetic keratopathy on corneal optical density, central corneal thickness, and corneal endothelial cell counts. (27588090)
2016
9
Dendritiform Keratopathy Associated with Exposure to Polyquarternium-1, a Common Ophthalmic Preservative. (26686962)
2016
10
Descemet Stripping Automated Endothelial Keratoplasty in Fuchs' Endothelial Dystrophy versus Pseudophakic Bullous Keratopathy. (27994806)
2016
11
Infectious crystalline keratopathy caused by Cladosporium sp. after penetrating keratoplasty: a case report. (27621671)
2016
12
Pharmacologic Management of Pressure-Induced Stromal Keratopathy after LASIK. (27003814)
2016
13
Keratopathy due to ophthalmic drug abuse with corneal melting and perforation presenting as Mooren-like ulcer: A case report. (27347060)
2016
14
Neurotrophic keratopathy secondary to trigeminal nerve aplasia in patient with Goldenhar syndrome. (26819096)
2016
15
An association between systemic cyclosporine administration and development of acute bullous keratopathy in cats. (26880480)
2016
16
Comparison of Long-term Clinical Outcomes between Descemet's Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty in Patients with Bullous Keratopathy. (27980363)
2016
17
Non-Descemet Stripping Automated Endothelial Keratoplasty for Bullous Keratopathy in Buphthalmic Eye. (27462256)
2016
18
The benefit of preventing exposure keratopathy in icu patient: a case report. (27217884)
2016
19
Crystalline keratopathy due to intravenous immunoglobulin in a 12-year-old girl with Kawasaki disease. (27667371)
2016
20
Refractory Tamoxifen-Induced Keratopathy Despite Drug Withdrawal. (27918356)
2016
21
Comparison of corneal degeneration and calcific band keratopathy from 2000 to 2013 in 69 horses. (26773714)
2016
22
Corneal Collagen Cross Linking (CXL) in treatment of Pseudophakic Bullous Keratopathy. (27648049)
2016
23
Five-Year PROSE Treatment for Aniridic Keratopathy. (27668496)
2016
24
Tegaderm(TM)dressing and Lacri-lube ointment moisture chamber to manage exposure keratopathy. (27769340)
2016
25
Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells. (27077448)
2016
26
Optical coherence tomography of band keratopathy. (28039348)
2016
27
Prosthetic Replacement of the Ocular Surface Ecosystem Scleral Lens Therapy for Exposure Keratopathy. (27171131)
2016
28
Thymosin Beta 4: A Potential Novel Therapy for Neurotrophic Keratopathy, Dry Eye, and Ocular Surface Diseases. (27450739)
2016
29
Corneal Tattooing and Anterior Stromal Puncture for Treating Symptomatic Bullous Keratopathy. (26606297)
2016
30
Superficial Keratectomy and Conjunctival Advancement Hood Flap (SKCAHF) for the Management of Bullous Keratopathy: Validation in Dogs With Spontaneous Disease. (27538190)
2016
31
Anterior segment optical coherence tomography of silicone oil keratopathy. (27558194)
2016
32
Toxic Keratopathy Following the Use of Alcohol-Containing Antiseptics in Nonocular Surgery. (26913777)
2016
33
Post-septal upper eyelid loading for treatment of exposure keratopathy secondary to non-cicatricial lagophthalmos. (27541938)
2016
34
Infectious crystalline keratopathy in dogs and cats: clinical, in vivo confocal microscopic, histopathologic, and microbiologic features of eight cases. (27352988)
2016
35
Idiopathic stromal keratitis resembling central toxic keratopathy. (26210054)
2015
36
Real-Time Microscope-Integrated OCT to Improve Visualization in DSAEK for Advanced Bullous Keratopathy. (26509766)
2015
37
Stem cell therapies in the treatment of diabetic retinopathy and keratopathy. (26454200)
2015
38
Recurrent rates and risk factors associated with recurrent painful bullous keratopathy after primary phototherapeutic keratectomy. (26491241)
2015
39
Evaluation of accelerated corneal collagen cross-linking for the treatment of bullous keratopathy in eight dogs (10 eyes). (25959108)
2015
40
Erlotinib-related keratopathy in a patient underwent laser in situ keratomileusis. (26264534)
2015
41
Images in clinical medicine. Amiodarone-induced vortex keratopathy. (25901429)
2015
42
Changes of Ocular Surface and the Inflammatory Response in a Rabbit Model of Short-Term Exposure Keratopathy. (26334533)
2015
43
Long-term symptomatic relief of bullous keratopathy with amniotic membrane transplant. (25586624)
2015
44
The use of endoillumination probe-assisted Descemet membrane endothelial keratoplasty for bullous keratopathy secondary to argon laser iridotomy. (25609910)
2015
45
Simultaneous Descemet's membrane endothelial keratoplasty and posterior iris-claw-fixated intra ocular lens implantation (IOL) in management of aphakic bullous keratopathy. (26286755)
2015
46
Potential New Modes of Treatment of Neurotrophic Keratopathy. (26448169)
2015
47
Treatment of neurotrophic keratopathy with nicergoline. (25625360)
2015
48
Etiologies, Quantitative Hypoesthesia, and Clinical Outcomes of Neurotrophic Keratopathy. (25828513)
2015
49
Vortex Keratopathy Presumed Secondary to AZD9291. (26709481)
2015
50
Bilateral central toxic keratopathy after laser in situ keratomileusis. (26621902)
2015

Variations for Keratopathy

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Expression for genes affiliated with Keratopathy

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Search GEO for disease gene expression data for Keratopathy.

Pathways for genes affiliated with Keratopathy

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GO Terms for genes affiliated with Keratopathy

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Cellular components related to Keratopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interstitial matrixGO:000561410.2IGF1, TNC
2neuronal cell bodyGO:00430259.5IGF1, NLRP1, TAC1, TGFB1
3basement membraneGO:00056049.4FBN1, NID1, TNC
4extracellular matrixGO:00310128.9FBN1, NID1, TGFB1, TNC
5extracellular regionGO:00055768.3FBN1, IGF1, NID1, TAC1, TGFB1, TNC
6proteinaceous extracellular matrixGO:00055788.2FBN1, NID1, TGFB1, TNC
7extracellular spaceGO:00056157.7AKR1B1, FBN1, IGF1, TAC1, TGFB1, TNC

Biological processes related to Keratopathy according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1cell activationGO:000177510.4IGF1, TGFB1
2positive regulation of protein secretionGO:005071410.4IGF1, TGFB1
3positive regulation of transcription regulatory region DNA bindingGO:200067910.4IGF1, TGFB1
4protein kinase B signalingGO:004349110.3IGF1, TGFB1
5regulation of gene expressionGO:001046810.1IGF1, PAX6, TGFB1
6cellular response to insulin-like growth factor stimulusGO:19903149.9FBN1, TGFB1
7agingGO:00075689.9IGF1, TGFB1, VCAM1
8response to lipopolysaccharideGO:00324969.8IGF1, TAC1, VCAM1
9positive regulation of transcription, DNA-templatedGO:00458939.8AIRE, IGF1, PAX6, TGFB1
10response to hypoxiaGO:00016669.8IGF1, TGFB1, VCAM1
11salivary gland morphogenesisGO:00074359.8PAX6, TGFB1
12response to woundingGO:00096119.4PAX6, TGFB1, TNC
13extracellular matrix organizationGO:00301988.8FBN1, NID1, TNC, VCAM1

Molecular functions related to Keratopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:00051788.8FBN1, IGF1, VCAM1

Sources for Keratopathy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet