MCID: KRT008
MIFTS: 47

Keratopathy malady

Summaries for Keratopathy

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Keratopathy can refer to: more...

MalaCards: Keratopathy is related to bullous keratopathy and band keratopathy. An important gene associated with Keratopathy is SOD3 (superoxide dismutase 3, extracellular), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Platelet degranulation . The compounds estrogen and ly303870 have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and craniofacial.

Aliases & Classifications for Keratopathy

Sources:
8Disease Ontology, 10DISEASES, 31LifeMap Discovery™, 61UMLS, 40NCIt
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Aliases & Descriptions:

keratopathy 8 10 31 61


External Ids:

Disease Ontology8 DOID:2283
NCIt40 C27012

Related Diseases for Keratopathy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Keratopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 130)
idRelated DiseaseScoreTop Affiliating Genes
1bullous keratopathy31.6SOD3, TNC, FBN1, DCN, IL1A, TGFB2
2band keratopathy31.2GLYR1, SLC4A4
3fuchs' endothelial dystrophy30.3COL8A2, AQP1
4corneal disease30.3IL1A, TGFB2
5arthritis30.0FBN1, SOD3, IL1A, TAC1
6atherosclerosis29.8IL1A, PDGFB, SOD3, FBN1, DCN
7neurotrophic keratopathy10.6
8aniridia10.4
9hypercalcemia10.1
10limbal stem cell deficiency10.0
11crohn's disease10.0
12xerophthalmia10.0
13keratomalacia10.0
14cystinosis10.0
15herpes zoster10.0
16fabry disease10.0
17astigmatism10.0
18strabismus10.0
19uveitis10.0
20micro syndrome10.0
21cataract-glaucoma10.0
22cogan's syndrome10.0
23mycobacterium abscessus10.0
24stromal keratitis10.0
25acanthamoeba keratitis10.0
26aortic aneurysm10.0FBN1
27primary open angle glaucoma10.0TGFB2
28dilated cardiomyopathy10.0FBN1
29peritonitis10.0AQP1
30gingivitis10.0IL1A
31pancreatitis10.0TAC1
32hypertension10.0TAC1
33hepatitis10.0PDGFB
34periodontitis10.0IL1A
35pneumonia10.0TGFB2, SOD3
36ehlers-danlos syndrome10.0FBN1, DCN
37lichen planus10.0FBN1
38hydrarthrosis10.0AQP9
39proliferative vitreoretinopathy10.0TGFB2
40marfan syndrome10.0DCN, FBN1
41corneal dystrophy10.0COL8A2
42diabetic retinopathy10.0TGFB2, PDGFB
43chondrosarcoma10.0TNC
44colon cancer10.0DCN, TAC1
45cataract10.0TGFB2, TGFB3, SLC4A4
46polyhydramnios10.0AQP1, AQP9
47tuberculosis10.0PDGFB, DCN
48hypertrophic scars10.0TGFB3, DCN, FBN1, TNC
49keloids10.0TNC, DCN, TGFB3, TGFB2
50colorectal cancer10.0TGFB3, TGFB2

Graphical network of the top 20 diseases related to Keratopathy:



Diseases related to keratopathy

Clinical Features for Keratopathy

Drugs & Therapeutics for Keratopathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
See all sources

Approved drugs:

Search CenterWatch for Keratopathy

Drug clinical trials:

Search ClinicalTrials for Keratopathy

Search NIH Clinical Center for Keratopathy

Search CenterWatch for Keratopathy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Keratopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Keratopathy:
Adipose-derived stem cells for treatment of bilateral limbic-associated keratopathy
Embryonic/Adult Cultured Cells Related to Keratopathy:
Adipose-derived stem cells

Genetic Tests for Keratopathy

Anatomical Context for Keratopathy

Animal Models for Keratopathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Keratopathy

Sources:
51PubMed
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Articles related to Keratopathy:

(show top 50)    (show all 632)
idTitleAuthorsYear
1
An atypical case of herpes simplex virus endotheliitis presented as bullous keratopathy. (23957427)
2013
2
In vivo morphology of the limbal palisades of vogt correlates with progressive stem cell deficiency in aniridia-related keratopathy. (23860752)
2013
3
Tomographic corneal profile analysis of central toxic keratopathy after LASIK. (22045389)
2012
4
Pro-inflammatory cytokines and gelatinases in climatic droplet keratopathy. (22570354)
2012
5
Confocal microscopy of contact lens keratitis presenting as central toxic keratopathy. (21808198)
2011
6
A case of crystalline keratopathy in monoclonal gammopathy of undetermined significance (MGUS). (21655047)
2011
7
Immunohistofluorescence analysis of myofibroblast transdifferentiation in human corneas with bullous keratopathy. (21866044)
2011
8
A novel mouse model for neurotrophic keratopathy: trigeminal nerve stereotactic electrolysis through the brain. (21071731)
2011
9
Actinomyces infectious crystalline keratopathy. (21482881)
2011
10
Anterior Segment Optical Coherence Tomography Imaging of Central Toxic Keratopathy. (20429496)
2010
11
Cytosine-arabinoside-induced keratopathy: a model of corneal proliferation kinetics. (20332655)
2010
12
Transpositional Autokeratoplasty in a Patient with Unilateral Choroidal Melanoma and Contralateral Exposure Keratopathy. (20337330)
2010
13
Chronic and delayed mustard gas keratopathy: a histopathologic and immunohistochemical study. (20491046)
2010
14
Corneal collagen cross-linking in bullous keratopathy. (19714792)
2009
15
Nummular keratopathy in a patient with Hyper-IgD Syndrome. (19656398)
2009
16
Palpebral spring in the management of lagophthalmos and exposure keratopathy secondary to facial nerve palsy. (19617783)
2009
17
Proteomic analysis of climatic keratopathy droplets. (18378572)
2008
18
Open clinical study of eye-drops containing tetrapeptides derived from substance P and insulin-like growth factor-1 for treatment of persistent corneal epithelial defects associated with neurotrophic keratopathy. (18511539)
2008
19
Re: Resolution of autoimmune polyglandular syndrome-associated keratopathy with keratolimbal stem cell transplantation: case report and historical literature review. (18434861)
2008
20
Amniotic membrane transplantation for painful bullous keratopathy. (17294377)
2007
21
"Steel wool keratopathy": a clinical sign of chronic inflammation. (17077672)
2006
22
In vivo confocal microscopic findings of interlamellar stromal keratopathy induced by elevated intraocular pressure. (16931274)
2006
23
Confocal microscopy of Thygeson's superficial punctate keratopathy. (15670099)
2005
24
New insights into the diagnosis and treatment of neurotrophic keratopathy. (17131013)
2005
25
Epithelial cell, keratocyte, and endothelial cell apoptosis in Fuchs' dystrophy and in pseudophakic bullous keratopathy. (15751234)
2005
26
Post-LASIK corneal flap displacement following penetrating keratoplasty for bullous keratopathy. (16160509)
2005
27
Combined treatment for band keratopathy. (15608412)
2004
28
Infectious crystalline keratopathy histopathological characteristics. (14641273)
2003
29
Tegaderm transparent dressing (3M) for the treatment of chronic exposure keratopathy. (12544796)
2003
30
Re: Trujillo F, Dang D, Starck T. Xylene keratopathy: a case report and review of the literature. Cornea. 2003;22:88-90. (12827061)
2003
31
A novel grading method for superficial punctate keratopathy magnitude and its correlation with corneal epithelial permeability. (14609908)
2003
32
Infectious crystalline keratopathy. (10656309)
2000
33
Unsuspected infections crystalline keratopathy masquerading as corneal graft rejection. (9290379)
1997
34
Topical urea as a treatment for non-infectious keratopathy. (8883557)
1996
35
Vortex keratopathy associated with ibuprofen therapy. (8763326)
1996
36
Crystalline keratopathy from Dieffenbachia plant sap. (7880806)
1995
37
Treatment of calcific band keratopathy by Nd:YAG laser. (1638162)
1992
38
Corneal edema and bullous keratopathy. (1469737)
1992
39
Soemmering's ring support for posterior chamber intraocular lens implantation during penetrating keratoplasty. Changing trends in bullous keratopathy. (1513575)
1992
40
Band keratopathy secondary to an iris melanoma. (2019109)
1991
41
Fellow eyes in aphakic and pseudophakic bullous keratopathy. (2299582)
1990
42
Pseudophakic bullous keratopathy: relationship with endothelial cell density and use of a predictive cell loss model. A preliminary report. (3720342)
1986
43
Localized bullous keratopathy secondary to adherent lens capsule. (3707407)
1986
44
Pseudophakic bullous keratopathy. Relationship to preoperative corneal endothelial status. (6514281)
1984
45
Band keratopathy in MRL/l and MRL/n mice. (6847726)
1983
46
Band keratopathy in hypercalcemia of myeloma. (7074461)
1982
47
Bullous keratopathy after anterior-posterior radial keratotomy for myopia for myopic astigmatism. (7081358)
1982
48
Aphakic bullous keratopathy: preoperative fluorescein angiographic screening for macular edema. (7023826)
1981
49
Keratoplasty for bullous keratopathy with intraocular lens. (359527)
1978
50
Bullous keratopathy: a latent complication of chronic corneal disease. (4492813)
1974

Genetic Variations for Keratopathy

Expression for genes affiliated with Keratopathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Keratopathy

Search GEO for disease gene expression data for Keratopathy.

Pathways for genes affiliated with Keratopathy

Sources:
53R&D Systems, 54Reactome, 52QIAGEN, 30KEGG, 4Cell Signaling Technology, 56SinoBiological, 38NCBI BioSystems Database
See all sources

Pathways related to Keratopathy according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.4TGFB3
2
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10.4TGFB3
3
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10.3TGFB2, TGFB3
4
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10.3TGFB3, TGFB2
5
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10.3TGFB2, TGFB3
6
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10.3TGFB2, TGFB3
710.3TGFB2, TGFB3
8
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10.3TGFB3, TGFB2
910.3TGFB2, TGFB3
1010.3TNC, TGFB3, TGFB2
1110.2TGFB2, TGFB3, DCN
1210.2DCN, TGFB3, TGFB2
13
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10.2TGFB2, TGFB3, ITGB6
1410.2AQP1, SLC4A4, AQP9
1510.2AQP9, AQP3, AQP1
16
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10.2TGFB2, IL1A, TGFB3, PDGFB
17
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10.2TGFB3, TGFB2, IL1A, PDGFB
18
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10.1ITGB6, TGFB2, TGFB3, FBN1
19
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10.1PTK6, ITGB6, TNC, PDGFB
20
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10.1ITGB6, TGFB3, PDGFB, IL1A, TGFB2
21
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10.1TGFB3, TGFB2, ITGB6, PDGFB, IL1A
22
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10.0FBN1, ITGB6, TNC, PDGFB, DCN, COL8A2
23
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10.0FBN1, PDGFB, ITGB6, TNC, TGFB3, DCN
24
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9.9AQP3, AQP1, TGFB2, TGFB3, PDGFB, AQP9
25
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9.9COL8A2, PDGFB, TNC, ITGB6, FBN1, TGFB3
26
Hide members
9.8TGFB3, TNC, ITGB6, FBN1, PDGFB, COL8A2

Compounds for genes affiliated with Keratopathy

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Keratopathy according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8TAC1
2ly30387045 2911.7TAC1, CD160
3physalaemin45 2911.6CD160, TAC1
4forskolin45 50 1112.6TAC1, AQP3
5alginate4510.6DCN, TGFB3, TGFB2
6hg2+2910.6AQP9, AQP3, AQP1
7sr489684510.6CD160, TAC1
8mercury4510.6AQP3, AQP1, AQP9
9eledoisin45 2911.6CD160, TAC1
10pcmbs4510.6AQP1, AQP3
11silver4510.6TNC, PDGFB, AQP3, AQP1
12septide45 2911.6TAC1, CD160
13heparan sulfate45 2411.6FBN1, DCN, SOD3, TNC
14glycosaminoglycan4510.6TGFB3, IL1A, TGFB2, DCN, TNC
15hyaluronic acid45 2411.6IL1A, TNC, TGFB2, FBN1, DCN
16hgcl24510.6AQP1, AQP3
17senktide45 60 2912.5CD160, TAC1
18sodium dodecylsulfate4510.5FBN1, DCN, IL1A, TAC1
19vitamin d4510.5TGFB2, SOD3
20ascorbic acid45 2411.5TGFB2, TNC, IL1A, FBN1, SOD3
21serine4510.5IL1A, FBN1, PDGFB, SOD3
22heparin45 29 11 2413.5TAC1, IL1A, DCN, FBN1, SOD3
23urea45 11 2412.5AQP9, AQP3, AQP1, SOD3
24creatinine4510.5DCN, TGFB2, AQP3, IL1A, AQP1
25chondroitin sulfate45 2411.5DCN, FBN1, TNC
26ribonucleic acid4510.5TGFB2, IL1A, PDGFB, DCN, TGFB3
27cyclosporin a45 29 6012.5TGFB2, PDGFB, DCN, CD160
28tgf beta14510.5TGFB3, DCN, FBN1, TNC, PDGFB, TGFB2
29mepyramine45 1111.4IL1A, TAC1
30chloride4510.4SLC4A4, TAC1, AQP3, AQP1
31paraffin4510.4DCN, TNC, PDGFB, TGFB3, TGFB2, AQP1
32progesterone45 60 29 11 2414.4TGFB3, PDGFB, IL1A, TNC, FBN1, TGFB2
33acetazolamide45 1111.4AQP1, SLC4A4
34neurocan4510.3DCN, TNC
35retinoic acid45 2411.3TNC, DCN, TGFB2, TGFB3, FBN1, IL1A
36glucose4510.3AQP1, TGFB2, AQP9, AQP3
37oligonucleotide4510.3PDGFB, TNC, AQP1, TGFB2, TGFB3, DCN
38dexamethasone45 50 29 1113.3AQP1, TGFB2, TGFB3, AQP3, TAC1, DCN
39arginine4510.3TAC1, DCN, FBN1, SOD3, AQP1, IL1A
40acetylcholine45 50 29 11 2414.3SOD3, IL1A, TAC1, CD160
41vegf4510.3SOD3, PDGFB, TNC, DCN, IL1A, AQP1
42cysteine4510.3SOD3, TNC, FBN1, DCN, TAC1, AQP1
43glutamate4510.3TAC1, TNC, SLC4A4, TGFB2, DCN, IL1A
44nitric oxide45 11 2412.3TAC1, TGFB3, AQP1, TGFB2, IL1A, PDGFB
45lipid4510.2TNC, PDGFB, FBN1, AQP1, TAC1, TGFB3
46mannitol45 1111.2AQP9, AQP1, AQP3
47steroid4510.2TGFB2, DCN, TAC1, TGFB3, AQP1
48sodium nitroprusside4510.1TAC1, SOD3, AQP1
49tyrosine4510.1PDGFB, TNC, SLC4A4, PTK6, TAC1, TGFB3
50polyglycolic acid4510.0TGFB3, PDGFB

GO Terms for genes affiliated with Keratopathy

Sources:
16Gene Ontology
See all sources

Cellular components related to Keratopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:00560410.3FBN1, TNC, COL8A2
2extracellular matrixGO:03101210.1TGFB2, COL8A2, SOD3, TNC, FBN1, DCN
3platelet alpha granule lumenGO:0310939.9TGFB2, TGFB3, PDGFB
4basolateral plasma membraneGO:0163239.9PDGFB, SLC4A4, AQP1, AQP3, AQP9
5extracellular spaceGO:0056159.8SOD3, PDGFB, TNC, FBN1, DCN, IL1A
6extracellular regionGO:0055769.7COL8A2, PDGFB, TNC, KERA, FBN1, DCN

Biological processes related to Keratopathy according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1menstrual cycle phaseGO:02260110.6TGFB2, TGFB3
2negative regulation of macrophage cytokine productionGO:01093610.6TGFB2, TGFB3
3positive regulation of saliva secretionGO:04687810.5TAC1, AQP1
4glycerol transportGO:01579310.5AQP1, AQP9
5water transportGO:00683310.5AQP1, AQP9, AQP3
6salivary gland morphogenesisGO:00743510.5TGFB3, TGFB2
7positive regulation of cell divisionGO:05178110.5PDGFB, TGFB2, TGFB3, IL1A
8odontogenesisGO:04247610.5TGFB3, AQP3, AQP1, TGFB2
9response to hypoxiaGO:00166610.4TGFB2, SOD3, TGFB3, PDGFB
10SMAD protein import into nucleusGO:00718410.4TGFB2, TGFB3
11cell growthGO:01604910.4TGFB2, TGFB3, PDGFB
12response to woundingGO:00961110.4TGFB2, PDGFB, TNC
13response to copper ionGO:04668810.3IL1A, SOD3
14platelet degranulationGO:00257610.3PDGFB, TGFB2, TGFB3
15transforming growth factor beta receptor signaling pathwayGO:00717910.2TGFB3, TGFB2, PDGFB
16positive regulation of epithelial cell migrationGO:01063410.2TGFB2, TAC1
17extracellular matrix organizationGO:03019810.1PDGFB, ITGB6, DCN, TNC, TGFB3, TGFB2
18protein phosphorylationGO:0064689.8TGFB2, PTK6, PBK, PDGFB

Molecular functions related to Keratopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1type II transforming growth factor beta receptor bindingGO:00511410.3TGFB2, TGFB3
2water channel activityGO:01525010.1AQP9, AQP3, AQP1
3water transmembrane transporter activityGO:00537210.0AQP9, AQP1

Products for genes affiliated with Keratopathy

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  • Lysates
  • Antibodies

Sources for Keratopathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet