MCID: KRT008
MIFTS: 52

Keratopathy malady

Summaries for Keratopathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Keratopathy can refer to: more...

MalaCards: Keratopathy is related to bullous keratopathy and band keratopathy. An important gene associated with Keratopathy is SOD3 (superoxide dismutase 3, extracellular), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Platelet degranulation . The compounds estrogen and ly303870 have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and brain, and related mouse phenotypes are respiratory system and craniofacial.

Aliases & Classifications for Keratopathy

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8Disease Ontology, 10DISEASES, 30LifeMap Discovery™, 60UMLS, 39NCIt
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Aliases & Descriptions:

keratopathy 8 10 30 60


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Disease Ontology8 DOID:2283
NCIt39 C27012

Related Diseases for Keratopathy

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17GeneCards, 18GeneDecks
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Diseases related to Keratopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1bullous keratopathy31.5SOD3, TNC, TGFB2, IL1A, DCN, FBN1
2band keratopathy31.1GLYR1, SLC4A4
3cataract30.5SLC4A4, TGFB3, TGFB2
4glaucoma30.5FBN1, SLC4A4, AQP1, TGFB2
5keratoconus30.3COL8A2, SOD3, TNC, KERA, DCN
6fuchs' endothelial dystrophy30.3AQP1, COL8A2
7corneal disease30.3IL1A, TGFB2
8corneal dystrophy30.1COL8A2
9diabetes mellitus30.1TAC1
10corneal edema30.1PBK
11arthritis30.0SOD3, FBN1, IL1A, TAC1
12melanoma29.9PDGFB, TNC, DCN, IL1A, TGFB3, TGFB2
13pneumonia29.7TGFB2, SOD3
14rheumatoid arthritis29.7SOD3, DCN, IL1A, TAC1
15atherosclerosis29.7SOD3, PDGFB, FBN1, DCN, IL1A
16dermatitis29.7TAC1, IL1A
17sarcoidosis29.7PDGFB, DCN, IL1A, TAC1, TGFB2
18keratitis10.4
19aniridia10.4
20lagophthalmos10.3
21myeloma10.3
22multiple myeloma10.2
23corneal ulcer10.1
24hypercalcemia10.1
25limbal stem cell deficiency10.0
26crohn's disease10.0
27xerophthalmia10.0
28keratomalacia10.0
29cystinosis10.0
30herpes zoster10.0
31fabry disease10.0
32astigmatism10.0
33corneal deposit10.0
34corneal neovascularization10.0
35herpes simplex10.0
36hyperparathyroidism10.0
37leprosy10.0
38myopia10.0
39scleritis10.0
40strabismus10.0
41uveitis10.0
42neurotrophic keratopathy10.0
43aortic aneurysm10.0FBN1
44primary open angle glaucoma10.0TGFB2
45dilated cardiomyopathy10.0FBN1
46peritonitis10.0AQP1
47gingivitis10.0IL1A
48pancreatitis10.0TAC1
49hypertension10.0TAC1
50hepatitis10.0PDGFB

Graphical network of the top 20 diseases related to Keratopathy:



Diseases related to keratopathy

Clinical Features for Keratopathy

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Drugs & Therapeutics for Keratopathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Keratopathy

Drug clinical trials:

Search ClinicalTrials for Keratopathy

Search NIH Clinical Center for Keratopathy

Search CenterWatch for Keratopathy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Keratopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Keratopathy:
Adipose-derived stem cells for treatment of bilateral limbic-associated keratopathy
Embryonic/Adult Cultured Cells Related to Keratopathy:
Adipose-derived stem cells

Genetic Tests for Keratopathy

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Anatomical Context for Keratopathy

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32MalaCards
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MalaCards organs/tissues related to Keratopathy:

32
Endothelial, Eye, Brain, Lung, Skin, Testes, B cells

Animal Models for Keratopathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Keratopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.1ITGB6, DCN, AQP1, TGFB3, TGFB2
2MP:000538210.0TGFB2, TGFB3, AQP3, SLC4A4, DCN, FBN1
3MP:00053679.9PDGFB, FBN1, DCN, TAC1, SLC4A4, AQP1
4MP:00053919.9COL8A2, PDGFB, KERA, DCN, SLC4A4, AQP1
5MP:00053859.7PDGFB, FBN1, IL1A, TAC1, SLC4A4, AQP1
6MP:00053879.7TGFB2, SOD3, PDGFB, KERA, ITGB6, FBN1
7MP:00107719.6PDGFB, ITGB6, FBN1, DCN, TAC1, SLC4A4
8MP:00053979.6PDGFB, KERA, ITGB6, FBN1, DCN, IL1A
9MP:00053769.6FBN1, ITGB6, TNC, PDGFB, SOD3, DCN

Publications for Keratopathy

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50PubMed
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Articles related to Keratopathy:

(show top 50)    (show all 630)
idTitleAuthorsYear
1
Central toxic keratopathy: a clinical case series. (23536420)
2013
2
Characteristics of, prevalence of, and risk factors for corneal pigmentation (pigmentary keratopathy) in Pugs. (23971846)
2013
3
Early amniotic membrane transplantation for toxic keratopathy secondary to topical proparacaine abuse: a report of seven cases. (23360240)
2013
4
Descemet stripping automated endothelial keratoplasty for bullous keratopathy after anterior-posterior radial keratotomy. (23770978)
2013
5
Use of dermal filler to improve exposure keratopathy in a patient with restrictive dermopathy. (23387462)
2013
6
Bilateral nerve alterations in a unilateral experimental neurotrophic keratopathy model: a lateral conjunctival approach for trigeminal axotomy. (23967133)
2013
7
Treatment of herpes zoster related corneal neovascularisation and lipid keratopathy by photodynamic therapy. (24112362)
2013
8
Beauveria bassiana keratitis in bullous keratopathy: antifungal sensitivity testing and management. (22467587)
2012
9
Management of trachomatous keratopathy by automated lamellar therapeutic keratoplasty. (22902489)
2012
10
Surgical intervention in central toxic keratopathy. (22562297)
2012
11
Excimer laser phototherapeutic keratectomy for the treatment of silicone oil-induced band-shaped keratopathy. (21455078)
2011
12
Involvement of advanced glycation end products, oxidative stress and nuclear factor-kappaB in the development of diabetic keratopathy. (21104267)
2011
13
Photodynamic therapy for neovascularization in lipid keratopathy. (20453416)
2010
14
Neurotrophic keratopathy; its pathophysiology and treatment. (20376784)
2010
15
A 10.0-mm posterior lamellar graft for bullous keratopathy in a buphthalmic eye. (20595891)
2010
16
Prevention of exposure keratopathy in intensive care unit. (22553589)
2010
17
Nonpreserved amniotic membrane transplantation for bilateral toxic keratopathy caused by topical anesthetic abuse: a case report. (20698973)
2010
18
Amyloidosis-associated neurotrophic keratopathy precipitated by overcorrected blepharoptosis. (19421037)
2009
19
Amiodarone-induced keratopathy: full-thickness corneal involvement. (18327053)
2008
20
Management of angle-closure glaucoma in East Asian eyes: a response to argon laser iridotomy-induced bullous keratopathy, a growing problem in Japan. (18723753)
2008
21
Descemetocoele from exposure keratopathy. (18025639)
2007
22
Amniotic membrane transplantation with anterior stromal micropuncture for treatment of painful bullous keratopathy in eyes with poor visual potential. (17251820)
2007
23
Therapeutic efficacy of 5% NaCl hypertonic solution in patients with bullous keratopathy. (16848159)
2006
24
A boy with fever and whorl keratopathy. (16755678)
2006
25
The implications of the upregulation of ICAM-1/VCAM-1 expression of corneal fibroblasts on the pathogenesis of allergic keratopathy. (16303942)
2005
26
Mucous plaque keratitis associated with aniridia keratopathy. (15375363)
2005
27
Autologous serum application in the treatment of neurotrophic keratopathy. (15177961)
2004
28
Keratopathy of multiple myeloma masquerading as corneal crystals of ocular cystinosis. (15008615)
2004
29
Xylene keratopathy: a case report and review of the literature. (12502960)
2003
30
Familial, band-shaped, spheroidal keratopathy histopathology in ethnic Chinese siblings. (12410034)
2002
31
Infectious post-LASIK crystalline keratopathy caused by nontuberculous mycobacteria. (11973397)
2002
32
Congenital hereditary endothelial dystrophy and band keratopathy in an infant with corpus callosum agenesis. (11413417)
2001
33
Association of tear lipid layer interference patterns with superficial punctate keratopathy. (9634902)
1998
34
Management of coexisting pseudophakic bullous keratopathy and open-angle glaucoma. (9493117)
1998
35
A case of infectious crystalline keratopathy occurring long after penetrating keratoplasty. (9436890)
1998
36
Climatic droplet keratopathy in leprosy. (8627116)
1996
37
Irreversible bullous keratopathy after air bag trauma. (8728625)
1996
38
Vortex keratopathy associated with atovaquone. (7485371)
1995
39
The relationship between cataract and climatic droplet keratopathy in Mongolia. (7825419)
1994
40
The origin of keratopathy in chronic allergic eye disease: a histopathological study. (8253220)
1993
41
The bandage lens in bullous keratopathy. (2594381)
1989
42
Band keratopathy and calcific lid lesions in tumoral calcinosis. Case reports. (3369991)
1988
43
Visual acuity, refractive error, and astigmatism following corneal transplantation for pseudophakic bullous keratopathy. (3909036)
1985
44
Bank keratopathy after orbicularis extirpation for essential blepharospasm. (3985818)
1985
45
Band keratopathy with bilateral deafness as a presenting sign of hyperparathyroidism. (889762)
1977
46
Aphakic bullous keratopathy treated with prosthokeratoplasty. An analysis of 34 consecutive cases. (1252179)
1976
47
Soft contact lens treatment of bullous keratopathy. (1064214)
1975
48
Penetrating corneal transplants for aphakic bullous keratopathy. (4875497)
1968
49
BAND KERATOPATHY AND CONJUNCTIVAL CALCIFICATION IN HYPOPHOSPHATASIA. (14109032)
1964
50
Band-keratopathy with a report of a case of Fanconi's syndrome with calcium deposits in the cornea. (13635723)
1958

Genetic Variations for Keratopathy

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Expression for genes affiliated with Keratopathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratopathy

Search GEO for disease gene expression data for Keratopathy.

Pathways for genes affiliated with Keratopathy

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Sources:
52R&D Systems, 53Reactome, 51QIAGEN, 29KEGG, 4Cell Signaling Technology, 55SinoBiological, 37NCBI BioSystems Database
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Pathways related to Keratopathy according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.4TGFB3
2
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10.4TGFB3
3
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10.3TGFB2, TGFB3
4
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10.3TGFB3, TGFB2
5
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10.3TGFB2, TGFB3
6
Hide members
10.3TGFB2, TGFB3
710.3TGFB2, TGFB3
8
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10.3TGFB2, TGFB3
910.3TGFB2, TGFB3
1010.3TGFB2, TGFB3, TNC
1110.2DCN, TGFB3, TGFB2
1210.2TGFB2, TGFB3, DCN
13
Hide members
10.2TGFB2, TGFB3, ITGB6
1410.2SLC4A4, AQP1, AQP9
1510.2AQP1, AQP3, AQP9
16
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10.2PDGFB, IL1A, TGFB3, TGFB2
17
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10.2TGFB2, TGFB3, IL1A, PDGFB
18
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10.1TGFB2, TGFB3, FBN1, ITGB6
19
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10.1PDGFB, TNC, ITGB6, PTK6
20
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10.1PDGFB, ITGB6, IL1A, TGFB3, TGFB2
21
Hide members
10.1PDGFB, ITGB6, IL1A, TGFB3, TGFB2
22
Hide members
10.0COL8A2, PDGFB, TNC, ITGB6, FBN1, DCN
23
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10.0TGFB3, DCN, FBN1, ITGB6, TNC, PDGFB
24
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9.9PDGFB, AQP1, AQP3, AQP9, TGFB3, TGFB2
25
Hide members
9.9COL8A2, PDGFB, TNC, ITGB6, FBN1, TGFB3
26
Hide members
9.8COL8A2, PDGFB, TNC, ITGB6, FBN1, IL1A

Compounds for genes affiliated with Keratopathy

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Keratopathy according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8TAC1
2ly30387044 2811.7TAC1, CD160
3physalaemin44 2811.6TAC1, CD160
4forskolin44 49 1112.6TAC1, AQP3
5alginate4410.6DCN, TGFB3, TGFB2
6hg2+2810.6AQP9, AQP3, AQP1
7sr489684410.6TAC1, CD160
8mercury4410.6AQP9, AQP3, AQP1
9eledoisin44 2811.6CD160, TAC1
10pcmbs4410.6AQP3, AQP1
11silver4410.6PDGFB, TNC, AQP1, AQP3
12senktide44 59 2812.6CD160, TAC1
13heparan sulfate44 2411.6DCN, FBN1, TNC, SOD3
14glycosaminoglycan4410.6TNC, DCN, IL1A, TGFB3, TGFB2
15hyaluronic acid44 2411.6TNC, FBN1, DCN, IL1A, TGFB2
16hgcl24410.6AQP1, AQP3
17septide44 2811.5CD160, TAC1
18sodium dodecylsulfate4410.5FBN1, DCN, IL1A, TAC1
19vitamin d4410.5TGFB2, SOD3
20ascorbic acid44 2411.5SOD3, TNC, FBN1, IL1A, TGFB2
21serine4410.5IL1A, FBN1, PDGFB, SOD3
22heparin44 28 11 2413.5SOD3, FBN1, DCN, IL1A, TAC1
23urea44 11 2412.5SOD3, AQP1, AQP3, AQP9
24creatinine4410.5TGFB2, AQP3, AQP1, IL1A, DCN
25chondroitin sulfate44 2411.5DCN, FBN1, TNC
26ribonucleic acid4410.5PDGFB, DCN, IL1A, TGFB3, TGFB2
27cyclosporin a44 28 5912.5PDGFB, DCN, CD160, TGFB2
28tgf beta14410.5PDGFB, TNC, FBN1, DCN, TGFB3, TGFB2
29mepyramine44 1111.4TAC1, IL1A
30chloride4410.4TAC1, SLC4A4, AQP1, AQP3
31paraffin4410.4PDGFB, TNC, DCN, AQP1, TGFB3, TGFB2
32progesterone44 59 28 11 2414.4PDGFB, TNC, FBN1, IL1A, TGFB3, TGFB2
33acetazolamide44 1111.4AQP1, SLC4A4
34neurocan4410.3DCN, TNC
35retinoic acid44 2411.3TNC, FBN1, DCN, IL1A, AQP3, TGFB3
36glucose4410.3AQP1, AQP3, AQP9, TGFB2
37oligonucleotide4410.3PDGFB, TNC, DCN, AQP1, AQP3, TGFB3
38dexamethasone44 49 28 1113.3TGFB2, PDGFB, DCN, TAC1, AQP1, AQP3
39arginine4410.3SOD3, FBN1, DCN, IL1A, TAC1, AQP1
40acetylcholine44 49 28 11 2414.3SOD3, CD160, IL1A, TAC1
41vegf4410.3SOD3, PDGFB, TNC, DCN, IL1A, AQP1
42cysteine4410.3SOD3, TNC, FBN1, DCN, TAC1, AQP1
43glutamate4410.3TNC, FBN1, DCN, CD160, IL1A, TAC1
44nitric oxide44 11 2412.3SOD3, PDGFB, DCN, IL1A, TAC1, AQP1
45lipid4410.2SOD3, PDGFB, TNC, FBN1, TAC1, AQP1
46mannitol44 1111.2AQP9, AQP3, AQP1
47steroid4410.2DCN, TAC1, AQP1, TGFB3, TGFB2
48sodium nitroprusside4410.1SOD3, TAC1, AQP1
49tyrosine4410.1PDGFB, TNC, FBN1, DCN, CD160, TAC1
50polyglycolic acid4410.0TGFB3, PDGFB

GO Terms for genes affiliated with Keratopathy

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16Gene Ontology
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Cellular components related to Keratopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:00560410.3FBN1, TNC, COL8A2
2extracellular matrixGO:03101210.1TGFB2, COL8A2, SOD3, TNC, FBN1, DCN
3platelet alpha granule lumenGO:0310939.9TGFB2, TGFB3, PDGFB
4basolateral plasma membraneGO:0163239.9PDGFB, SLC4A4, AQP1, AQP3, AQP9
5extracellular spaceGO:0056159.8SOD3, PDGFB, TNC, FBN1, DCN, IL1A
6extracellular regionGO:0055769.7COL8A2, PDGFB, TNC, KERA, FBN1, DCN

Biological processes related to Keratopathy according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of macrophage cytokine productionGO:01093610.6TGFB2, TGFB3
2menstrual cycle phaseGO:02260110.6TGFB2, TGFB3
3positive regulation of saliva secretionGO:04687810.5TAC1, AQP1
4glycerol transportGO:01579310.5AQP1, AQP9
5water transportGO:00683310.5AQP9, AQP3, AQP1
6salivary gland morphogenesisGO:00743510.5TGFB2, TGFB3
7positive regulation of cell divisionGO:05178110.5PDGFB, IL1A, TGFB3, TGFB2
8odontogenesisGO:04247610.5TGFB2, TGFB3, AQP3, AQP1
9response to hypoxiaGO:00166610.4SOD3, PDGFB, TGFB3, TGFB2
10SMAD protein import into nucleusGO:00718410.4TGFB2, TGFB3
11cell growthGO:01604910.4PDGFB, TGFB3, TGFB2
12response to woundingGO:00961110.4PDGFB, TNC, TGFB2
13response to copper ionGO:04668810.3IL1A, SOD3
14platelet degranulationGO:00257610.3PDGFB, TGFB3, TGFB2
15transforming growth factor beta receptor signaling pathwayGO:00717910.2TGFB2, TGFB3, PDGFB
16positive regulation of epithelial cell migrationGO:01063410.2TGFB2, TAC1
17extracellular matrix organizationGO:03019810.1TGFB2, COL8A2, PDGFB, TNC, ITGB6, FBN1
18protein phosphorylationGO:0064689.8PDGFB, PBK, PTK6, TGFB2

Molecular functions related to Keratopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1type II transforming growth factor beta receptor bindingGO:00511410.3TGFB2, TGFB3
2water channel activityGO:01525010.1AQP9, AQP3, AQP1
3water transmembrane transporter activityGO:00537210.0AQP9, AQP1

Products for genes affiliated with Keratopathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Keratopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet