Aliases & Classifications for Keratopathy

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Aliases & Descriptions for Keratopathy:

Name: Keratopathy 30 8 10 61


External Ids:

Disease Ontology8 DOID:2283
NCIt39 C27012

Summaries for Keratopathy

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Wikipedia:64 Keratopathy can refer to: more...

MalaCards based summary: Keratopathy is related to cataract and bullous keratopathy. An important gene associated with Keratopathy is SOD3 (superoxide dismutase 3, extracellular), and among its related pathways are Angiogenesis and Integrin cell surface interactions. The compounds uric acid and manganese superoxide have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and brain, and related mouse phenotypes are cardiovascular system and craniofacial.

Related Diseases for Keratopathy

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Diseases related to Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1cataract30.7TGFB2, SLC4A4
2bullous keratopathy30.5IL1A, SOD3, TGFB2, DCN, TNC, FBN1
3corneal disease30.4TGFB2, IL1A
4keratoconus30.3SOD3, DCN, TNC
5pneumonia30.2SOD3, TGFB2
6uveitis30.2IL1A, TGFB2
7myopia30.1FBN1, DCN
8arthritis30.0FBN1, SOD3, IL1A
9melanoma29.5TNC, DCN, TGFB2, IL1A
10rheumatoid arthritis29.4IL1A, SOD3, DCN
11atherosclerosis29.3IL1A, SOD3, DCN, FBN1
12band keratopathy10.8
13endotheliitis10.7
14neurotrophic keratopathy10.7
15keratitis10.5
16aniridia10.4
17aortic aneurysm10.4FBN1
18loeys-dietz syndrome10.4FBN1
19lagophthalmos10.3
20myeloma10.3
21multiple myeloma10.3
22vitreoretinopathy, neovascular inflammatory10.2TNC, TGFB2
23hyperhomocysteinemia10.2FBN1, SOD3
24herpes zoster10.2
25fuchs' endothelial dystrophy10.2
26hypercalcemia10.1
27herpes simplex10.1
28pulmonary fibrosis, idiopathic10.1IL1A, TNC
29dermatomyositis10.1IL1A, FBN1
30insulin-like growth factor i10.0
31fabry disease10.0
32leprosy10.0
33cystinosis10.0
34xerophthalmia10.0
35choroiditis10.0
36keratomalacia10.0
37astigmatism10.0
38corneal deposit10.0
39corneal neovascularization10.0
40corneal ulcer10.0
41hyperparathyroidism10.0
42ptosis10.0
43scleritis10.0
44strabismus10.0
45mycobacterium abscessus10.0
46marfan syndrome10.0DCN, FBN1
47abdominal aortic aneurysm10.0DCN, FBN1
48ehlers-danlos syndrome10.0FBN1, DCN
49gingival overgrowth10.0DCN, IL1A
50acute myocardial infarction10.0SOD3, TNC

Graphical network of the top 20 diseases related to Keratopathy:



Diseases related to keratopathy

Symptoms for Keratopathy

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Drugs & Therapeutics for Keratopathy

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Drug clinical trials:

Search ClinicalTrials for Keratopathy

Search NIH Clinical Center for Keratopathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Keratopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Keratopathy:
Adipose-derived stem cells for treatment of bilateral limbic-associated keratopathy
Embryonic/Adult Cultured Cells Related to Keratopathy:
Adipose-derived stem cells

Genetic Tests for Keratopathy

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Anatomical Context for Keratopathy

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MalaCards organs/tissues related to Keratopathy:

31
Endothelial, Eye, Brain, Lung, Skin, Testes, T cells, B cells

Animal Models for Keratopathy or affiliated genes

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MGI Mouse Phenotypes related to Keratopathy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.4SLC4A4, IL1A, TGFB2, FBN1
2MP:00053828.3SLC4A4, TGFB2, DCN, FBN1
3MP:00053678.2FBN1, DCN, TGFB2, SLC4A4
4MP:00053698.1FBN1, DCN, TGFB2, SLC4A4
5MP:00053907.9FBN1, DCN, TGFB2, SOD3, SLC4A4
6MP:00053977.5SLC4A4, IL1A, TGFB2, DCN, FBN1
7MP:00107687.5FBN1, DCN, TGFB2, SOD3, SLC4A4
8MP:00053877.3FBN1, DCN, TGFB2, SOD3, IL1A, SLC4A4
9MP:00053766.9SLC4A4, FBN1, TNC, DCN, TGFB2, SOD3

Publications for Keratopathy

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Articles related to Keratopathy:

(show top 50)    (show all 663)
idTitleAuthorsYear
1
Re: Arora etA al.: Role of Corneal Collagen Cross-Linking in Pseudophakic Bullous Keratopathy: AA Clinicopathological Study (Ophthalmology 2013;120:2413-8). (25015213)
2014
2
Neurotrophic keratopathy due to dorsolateral medullary infarction (Wallenberg syndrome): case report and literature review. (25472780)
2014
3
Midinfrared Laser Pancorneal Coagulation as a Method of Treatment for Painful Bullous Keratopathy. (23974894)
2013
4
Treatment of bullous keratopathy with corneal collagen cross-linking in two dogs. (24373539)
2013
5
Autologous tragal perichondrium transplantation: a novel approach for the management of painful bullous keratopathy. (23730105)
2013
6
Genetic background and climatic droplet keratopathy incidence in a mapuche population from Argentina. (24040292)
2013
7
New findings for an old disease: morphological studies on pseudoexfoliation syndrome-related keratopathy and binocular asymmetry. (24104940)
2013
8
In vivo confocal microscopy study of climatic droplet keratopathy. (22538217)
2012
9
Excimer laser phototherapeutic keratectomy for the treatment of silicone oil-induced band-shaped keratopathy. (21455078)
2011
10
Long-term outcome of central toxic keratopathy after photorefractive keratectomy. (21926568)
2011
11
Reproducibility of cornea measurements in anterior segment OCT images of normal eyes and eyes with bullous keratopathy analyzed with the Zhongshan Assessment Program. (21828152)
2011
12
Confocal microscopy of contact lens keratitis presenting as central toxic keratopathy. (21808198)
2011
13
Penetrating keratoplasty for bullous keratopathy after trabeculectomy. (18369373)
2009
14
In vivo morphometry of corneal endothelial cells in pseudoexfoliation keratopathy with glaucoma and cataract. (19365152)
2009
15
Neuroparalytic keratopathy as the first sign of a cerebral meningioma. (17894293)
2007
16
Persistent epithelial defects due to neurotrophic keratopathy treated with a substance p-derived peptide and insulin-like growth factor 1. (18158595)
2007
17
Ring keratopathy in a patient with psoriatic arthritis and ulcerative rectocolitis. (17365809)
2007
18
Therapeutic options for the management of early neurotrophic keratopathy: a case report and review. (17000411)
2006
19
Climatic droplet keratopathy in the Argentine Patagonia. (16564815)
2006
20
Anaesthetic abuse keratopathy as a manifestation of ocular Munchausen's syndrome. (16451265)
2006
21
Confocal microscopy of Thygeson's superficial punctate keratopathy. (15670099)
2005
22
Dendritic keratopathy in ocular rosacea. (15968176)
2005
23
The implications of the upregulation of ICAM-1/VCAM-1 expression of corneal fibroblasts on the pathogenesis of allergic keratopathy. (16303942)
2005
24
Infectious crystalline keratopathy histopathological characteristics. (14641273)
2003
25
Management of aniridic keratopathy with keratolimbal allograft: a limbal stem cell transplantation technique. (12511357)
2003
26
Filamentary keratopathy: a non-contact photomicrographic in vivo study in the human cornea. (14552592)
2003
27
Keratopathy in congenital aniridia. (17075635)
2003
28
Epithelial infectious crystalline keratopathy. (11228305)
2001
29
Neurotrophic keratopathy. (11352446)
2001
30
Ultrastructural morphology and expression of proteoglycans, betaig-h3, tenascin-C, fibrillin-1, and fibronectin in bullous keratopathy. (11371495)
2001
31
Clinical course of hurricane keratopathy. (10684839)
2000
32
Infectious crystalline keratopathy. (10656309)
2000
33
Delayed mustard gas keratopathy: clinical findings and confocal microscopy. (10577594)
1999
34
Infectious crystalline keratopathy: a case report. (9810093)
1998
35
The current situation of lagophthalmos and keratopathy of leprosy in PR China. (9598407)
1998
36
Association of tear lipid layer interference patterns with superficial punctate keratopathy. (9634902)
1998
37
Vortex keratopathy associated with atovaquone. (7485371)
1995
38
Pseudophakic bullous keratopathy and intraocular lens fixation. To suture or not: that is the question! (7945030)
1994
39
Climatic droplet keratopathy. (7936560)
1994
40
Climatic droplet keratopathy, exfoliation syndrome, and cataract. (1768663)
1991
41
The dilemma of pseudophakic bullous keratopathy. (2674810)
1989
42
Late development of localized band keratopathy in relation to a Molteno tube. (2743783)
1989
43
Results of penetrating keratoplasty for pseudophakic bullous keratopathy with the exchange of an intraocular lens. (2804025)
1989
44
The bandage lens in bullous keratopathy. (2594381)
1989
45
Intraocular lens replacement in pseudophakic bullous keratopathy. (3901432)
1985
46
Visual acuity, refractive error, and astigmatism following corneal transplantation for pseudophakic bullous keratopathy. (3909036)
1985
47
Band keratopathy in hypercalcemia of myeloma. (7074461)
1982
48
X-linked recessive ocular dystrophy with band keratopathy. (7258937)
1981
49
Endothelial degeneration and posterior collagenous proliferation in aphakic bullous keratopathy. (306751)
1978
50
Bullous keratopathy (Fuchs' endothelial dystrophy) treated systemically with 4-trans-amino-cyclohexano-carboxylic acid. (302548)
1977

Variations for Keratopathy

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Expression for genes affiliated with Keratopathy

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Search GEO for disease gene expression data for Keratopathy.

Pathways for genes affiliated with Keratopathy

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Compounds for genes affiliated with Keratopathy

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Compounds related to Keratopathy according to GeneCards Suite gene sharing:

(show all 44)
idCompoundScoreTop Affiliating Genes
1uric acid44 2410.8SOD3, TGFB2
2manganese superoxide449.7IL1A, SOD3
3neopterin449.6IL1A, TGFB2
4p003449.6TGFB2, TNC
5neurocan449.6DCN, TNC
6titanium449.6DCN, TNC
7alginate449.5DCN, TGFB2
8hydroxyproline44 24 1111.4FBN1, DCN
9hydrocortisone44 1 60 1112.4TGFB2, IL1A
101,25 dihydroxy vitamin d3449.3TGFB2, IL1A
11homocysteine44 2410.3SOD3, FBN1
12h2o2449.2TNC, IL1A, SOD3
13cycloheximide449.2IL1A, TGFB2, TNC
14carboplatin44 50 1111.1DCN, IL1A
15matrigel449.1TGFB2, TNC, DCN
16chondroitin sulfate44 2410.1TNC, FBN1, DCN
17paraffin449.1DCN, TGFB2, TNC
18procollagen449.0DCN, IL1A, TNC
19ribonucleic acid448.9TGFB2, DCN, IL1A
20vitamin d448.9SOD3, TGFB2, FBN1, IL1A
21sodium dodecylsulfate448.9IL1A, DCN, FBN1
22genistein44 28 60 1 24 1113.9DCN, TGFB2, IL1A
23cyclosporin a44 28 6010.9DCN, IL1A, TGFB2
24pge2448.9DCN, IL1A, TGFB2
25oligonucleotide448.9TGFB2, DCN, TNC
26progesterone44 28 60 24 1112.8FBN1, TNC, TGFB2, IL1A
27heparan sulfate44 249.8FBN1, TNC, DCN, SOD3
28aspartate448.8SLC4A4, IL1A, DCN
29tgf beta1448.7TGFB2, FBN1, DCN, TNC
30estrogen448.6DCN, FBN1, TNC, TGFB2
31glycosaminoglycan448.6DCN, TGFB2, IL1A, TNC
32nitric oxide44 24 1110.6TGFB2, SOD3, IL1A, DCN
33creatinine448.6TNC, IL1A, TGFB2, DCN
34dexamethasone44 50 28 1111.5IL1A, TNC, TGFB2, DCN
35ascorbic acid44 249.5FBN1, SOD3, TGFB2, TNC, IL1A
36arginine448.5FBN1, DCN, SOD3, IL1A
37cysteine448.3FBN1, SOD3, TGFB2, TNC, DCN
38vegf448.2SOD3, IL1A, TGFB2, DCN, TNC
39tyrosine448.1FBN1, DCN, TGFB2, TNC, SLC4A4
40hyaluronic acid44 249.1TNC, TGFB2, IL1A, DCN, FBN1
41retinoic acid44 249.1DCN, FBN1, TNC, TGFB2, IL1A
42heparin44 28 24 1110.7SOD3, FBN1, IL1A, TNC, DCN, TGFB2
43serine447.7TNC, FBN1, DCN, SOD3, IL1A, TGFB2
44glutamate447.6FBN1, TNC, DCN, SLC4A4, TGFB2, IL1A

GO Terms for genes affiliated with Keratopathy

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Cellular components related to Keratopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00057969.3SOD3, DCN
2basement membraneGO:00056049.2TNC, FBN1
3extracellular matrixGO:00310128.0SOD3, TGFB2, DCN, TNC, FBN1
4extracellular spaceGO:00056157.3FBN1, TNC, DCN, TGFB2, SOD3, IL1A
5extracellular regionGO:00055767.2FBN1, TNC, DCN, TGFB2, SOD3, IL1A

Biological processes related to Keratopathy according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to woundingGO:00096119.6TGFB2, TNC
2response to copper ionGO:00466889.6IL1A, SOD3
3positive regulation of cell divisionGO:00517819.5TGFB2, IL1A
4response to mechanical stimulusGO:00096129.1DCN, TNC
5extracellular matrix disassemblyGO:00226179.1DCN, FBN1
6wound healingGO:00420608.9TNC, DCN, TGFB2
7kidney developmentGO:00018228.8DCN, FBN1
8extracellular matrix organizationGO:00301988.4TGFB2, DCN, TNC, FBN1

Molecular functions related to Keratopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:00055079.5IL1A, SOD3

Sources for Keratopathy

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet