MCID: KRT009
MIFTS: 53

Keratosis malady

Summaries for Keratosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Keratosis (from: keratinocyte, the prominent cell type in the epidermis and -osis, abnormal) a growth of... more...

MalaCards: Keratosis, also known as hyperkeratosis, is related to actinic keratosis and seborrheic keratosis. An important gene associated with Keratosis is SAT1 (spermidine/spermine N1-acetyltransferase 1), and among its related pathways are MicroRNAs in cancer and Pathways in cancer. The compounds serine and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and testes, and related mouse phenotypes are growth/size and immune system.

Aliases & Classifications for Keratosis

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

keratosis 8 10
hyperkeratosis 60


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Disease Ontology8 DOID:161
NCIt39 C34747
SNOMED-CT56 254666005
MeSH34 D007642

Related Diseases for Keratosis

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17GeneCards, 18GeneDecks
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Diseases related to Keratosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 408)
idRelated DiseaseScoreTop Affiliating Genes
1actinic keratosis31.7TP63, CYP27B1, PCNA, GHR
2seborrheic keratosis31.5PIK3CA, FGFR3
3squamous cell carcinoma31.1PIK3CA, ATP2A2, GHR, DSP, DSG1, PCNA
4keratosis follicularis31.0ATP2A2, MBTPS2, SAT1
5basal cell carcinoma31.0TP63, BCL2, KRT10, CYP27B1
6melanoma30.8SAT1, PIK3CA, GHR, DSG1, PCNA, CYP27B1
7palmoplantar keratosis30.7CTSC, DSG1, SLURP1
8lichen planus30.6KRT10, KRT1
9keratosis follicularis spinulosa decalvans30.4KFSD, SAT1
10alopecia30.3MBTPS2
11keratoacanthoma30.3KRT10, PCNA
12mongolian spot30.3DSP, ATP2A2
13epidermolysis bullosa simplex30.2KRT10, KRT1
14skin disease30.2ATP2A2, DSP, DSG1, FGFR3, SLURP1, KRT1
15psoriasis30.2CYP27B1, KRT1, KRT10
16adenocarcinoma30.0CTSC, PIK3CA, GHR, PCNA, CYP27B1, KRT1
17cholesteatoma30.0KRT10
18nonepidermolytic palmoplantar keratoderma30.0CTSC, DSG1, KRT1, KRT10
19ichthyosis, cyclic, with epidermolytic hyperkeratosis30.0KRT1, KRT10
20retinoblastoma29.9PIK3CA, PCNA, FGFR3, KRT10, BCL2, TGFB2
21papilloma29.9TP63, KRT10, FGFR3, PCNA
22leukoplakia29.9PCNA, KRT1
23epidermolytic hyperkeratosis29.9KRT1, KRT10
24osteosarcoma29.7TGFB2, CYP27B1, GHR
25epidermolysis bullosa29.7DSP
26hailey-hailey disease29.7DSP, ATP2A2
27breast cancer29.7SAT1, PIK3CA, DSP, PCNA, CYP27B1, FGFR3
28amyloidosis29.7KRT10
29sarcoma29.6DSP, DSG1, TP63
30inverted follicular keratosis10.6
31skin squamous cell carcinoma10.4
32in situ carcinoma10.4
33acanthoma10.2
34alopecia congenita keratosis palmoplantaris10.2
35hyperkeratosis lenticularis perstans10.2
36inflamed seborrheic keratosis10.2
37epidermodysplasia verruciformis10.2
38vulvar seborrheic keratosis10.2
39keratosis follicularis dwarfism and cerebral atrophy10.2
40keratosis palmoplantaris striata i, ad10.2
41keratosis follicularis spinulosa decalvans, x-linked10.2
42keratosis pilaris atrophicans10.2
43skin melanoma10.1
44keratosis palmoplantaris striata 310.1
45keratoderma palmoplantar deafness10.1
46hyperkeratosis-hyperpigmentation syndrome10.1
47acquired hyperkeratosis10.1
48verrucous carcinoma10.1
49keratosis palmoplantaris papulosa10.1
50keratosis focal palmoplantar gingival10.1

Graphical network of the top 20 diseases related to Keratosis:



Diseases related to keratosis

Clinical Features for Keratosis

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Drugs & Therapeutics for Keratosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Keratosis

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Anatomical Context for Keratosis

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32MalaCards
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MalaCards organs/tissues related to Keratosis:

32
Skin, Breast, Testes, Liver, T cells, Colon, Kidney, Myeloid

Animal Models for Keratosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Keratosis:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537811.0TGFB2, SAT1, CTSC, PIK3CA, ATP2A2, GHR
2MP:000538710.9FGFR3, KRT10, BCL2, TP63, TGFB2, PCNA
3MP:000538910.9GHR, ATP2A2, TGFB2, TP63, SAT1, PIK3CA
4MP:000538410.9CTSC, SAT1, CYP27B1, BCL2, TP63, TGFB2
5MP:001077110.8CTSC, PIK3CA, CYP27B1, ATP2A2, KRT1, BCL2
6MP:000200610.8KRT10, TP63, BCL2, FGFR3, PIK3CA, SAT1
7MP:000537610.7GHR, CTSC, KRT1, FGFR3, CYP27B1, ATP2A2
8MP:000536710.6GHR, TGFB2, TP63, BCL2, FGFR3, CYP27B1
9MP:001076810.6TGFB2, TP63, BCL2, KRT10, KRT1, PIK3CA
10MP:000537510.5GHR, SAT1
11MP:000537910.3CYP27B1, PIK3CA, GHR, BCL2

Publications for Keratosis

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50PubMed
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Articles related to Keratosis:

(show top 50)    (show all 907)
idTitleAuthorsYear
1
Donor-derived keratinocytes in actinic keratosis and squamous cell carcinoma in patients with kidney transplant. (23190878)
2013
2
Seborrheic keratosis: reflectance confocal microscopy features and correlation with dermoscopy. (23415460)
2013
3
Pathobiology of actinic keratosis: ultraviolet-dependent keratinocyte proliferation. (23228301)
2013
4
Non-adherence to topical treatments for actinic keratosis. (24379656)
2013
5
Discrimination of squamous cell carcinoma in situ from seborrheic keratosis by color analysis techniques requires information from scale, scale-crust and surrounding areas in dermoscopy images. (23117020)
2012
6
Seborreic keratosis with Bowenoid transformation. (23189266)
2012
7
Seborrheic keratosis of the external auditory canal in a 1-year-old boy. (23427523)
2012
8
The value of the histopathologic examination in the diagnosis and management of the actinic keratosis. (23303015)
2012
9
Keratosis lichenoides chronica--case report. (22068797)
2011
10
Prospective, case-based assessment of sequential therapy with topical Fluorouracil cream 0.5% and ALA-PDT for the treatment of actinic keratosis. (21455547)
2011
11
Dermatology and the community nurse: actinic (solar) keratosis. (20216512)
2010
12
Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis. (19615018)
2010
13
Emerging drugs for actinic keratosis. (20670178)
2010
14
Differential expression of tetraspanin CD9 in basal cell and squamous cell carcinomas of the skin and actinic keratosis. (22966252)
2010
15
Inverted follicular keratosis of the nasal vestibule. (19643268)
2009
16
New dermoscopic pattern in actinic keratosis and related conditions. (19528439)
2009
17
Clinicopathological study of 21 cases of eyelid actinic keratosis. (18633577)
2009
18
Basal cell carcinoma arising in a seborrhoeic keratosis. (19486048)
2009
19
Atrophoderma vermiculatum: a case report and review of the literature on keratosis pilaris atrophicans. (19326693)
2009
20
Melanoma in-situ arising in seborrheic keratosis: a case report. (18947402)
2008
21
Carbon dioxide laser ablation and adjunctive destruction for Darier-White disease (keratosis follicularis). (18657162)
2008
22
Acantholytic dyskeratotic acanthoma: a variant of a benign keratosis. (18251744)
2008
23
Progressive symmetric erythro-keratosis associated with oligodontia, severe caries, disturbed hair growth and ectopic nail: a new syndrome? (18799882)
2008
24
Overexpression of p27KIP1 in seborrheic keratosis. (17942027)
2007
25
Proliferative actinic keratosis. (17894744)
2007
26
Association of specific p53 polymorphisms with keratosis in individuals exposed to arsenic through drinking water in West Bengal, India. (16930632)
2006
27
Keratoacanthoma developing in previous cryotherapy site for solar keratosis. (16441631)
2006
28
"Globulelike" dermoscopic structures in pigmented seborrheic keratosis. (14732676)
2004
29
Melanoma within the seborrheic keratosis. (15056152)
2004
30
Imiquimod 5% cream for actinic keratosis. (15382379)
2004
31
Desmoplastic seborrheic keratosis. (12775983)
2003
32
Delayed wound healing after three different treatments for widespread actinic keratosis on the atrophic bald scalp. (12974704)
2003
33
Summary of actinic keratosis studies with imiquimod 5% cream. (14616347)
2003
34
Comparison of the microvasculature of basal cell carcinoma and actinic keratosis using intravital microscopy and immunohistochemistry. (12890202)
2003
35
Pemphigus foliaceus presenting as eruptive seborrheic keratosis and responding to oral gold treatment. (12851996)
2002
36
A case of cutaneous ganglioneuroma developing within a lesion of seborrheic keratosis. (12081162)
2002
37
Actinic keratosis--a histoenzymological study. (12092184)
2001
38
Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis. (10581027)
1999
39
Aneuploidy in actinic keratosis and Bowen's disease--increased risk for invasive squamous cell carcinoma? (7577583)
1995
40
The expression of placental-type glutathione S-transferase (GST-pi) in human cutaneous carcinoma in situ, that is, actinic keratosis and Bowen's disease, compared with normal human skin. (7586130)
1995
41
Keratosis punctata of the palmar creases. A report on three generations, demonstrating an association with ichthyosis vulgaris and evidence of involvement of the acrosyringium. (8050151)
1994
42
Detection of human papillomavirus DNA in seborrheic keratosis by polymerase chain reaction. (1337468)
1992
43
Confirmation of X-linked inheritance and provisional mapping of the keratosis follicularis spinulosa decalvans gene on Xp in a large Dutch family. (1350668)
1992
44
Acantholytic variant of seborrheic keratosis. (2138642)
1990
45
Immunohistochemical study on keratin expression in certain cutaneous epithelial neoplasms. Basal cell carcinoma, pilomatricoma, and seborrheic keratosis. (2481408)
1989
46
Inverted follicular keratosis. A morbus sui generis? (6660429)
1983
47
Squamous cell carcinoma arising in seborrheic keratosis. (6970889)
1981
48
Inflammation of actinic keratosis secondary to systemic 5-fluorouracil. (5657401)
1968
49
Cellular response of seborrheic keratosis following croton oil irritation and surgical trauma with special reference to melanoacanthoma. (4222277)
1965
50
Actinic Keratosis of the Left Forearm Due to Driving an Automobile. (18745405)
1939

Genetic Variations for Keratosis

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Expression for genes affiliated with Keratosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratosis

Search GEO for disease gene expression data for Keratosis.

Pathways for genes affiliated with Keratosis

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29KEGG, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems
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Pathways related to Keratosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.6PIK3CA, FGFR3, BCL2, TP63
210.6PIK3CA, FGFR3, BCL2, TGFB2
310.5TGFB2, GHR, FGFR3
410.5DSG1, DSP
510.5TGFB2, BCL2

Compounds for genes affiliated with Keratosis

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Keratosis according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1serine4411.2TGFB2, BCL2, KRT10, KRT1, DSG1, DSP
2retinoic acid44 2412.2PIK3CA, GHR, DSP, DSG1, PCNA, TGFB2
3calcium44 49 11 2414.1KRT1, KRT10, TP63, TGFB2, DSG1, DSP
4arginine4411.1TP63, KRT1, FGFR3, PCNA, GHR, PIK3CA
5paraffin4411.1TP63, TGFB2, PCNA, BCL2, KRT10, KRT1
6progesterone44 59 28 11 2415.1TGFB2, BCL2, PIK3CA, TP63, KRT10, KRT1
7steroid4411.1KRT10, GHR, KRT1, SLURP1, CYP27B1, PIK3CA
8tyrosine4411.1GHR, DSP, CYP27B1, FGFR3, KRT1, PIK3CA
9testosterone44 59 11 2414.1PIK3CA, GHR, CYP27B1, PCNA, SLURP1, KRT1
10bromodeoxyuridine4411.0TP63, TGFB2, KRT1, PIK3CA, PCNA, KRT10
11histidine4411.0TGFB2, TP63, KRT10, GHR, CTSC
125fluorouracil4411.0PIK3CA, SAT1, TGFB2, BCL2, PCNA
13hematoxylin4411.0KRT10, KRT1, TP63, PCNA
14oligonucleotide4411.0CYP27B1, BCL2, TGFB2, GHR, FGFR3, PCNA
15tamoxifen44 49 28 1114.0TGFB2, BCL2, GHR, PIK3CA, PCNA
16dexamethasone44 49 28 1114.0PCNA, BCL2, TGFB2, PIK3CA
17vegf4411.0PIK3CA, FGFR3, PCNA, BCL2, TP63, TGFB2
18genistein44 28 59 2 11 2415.9TGFB2, BCL2, CYP27B1, PCNA, PIK3CA
19lysine4410.9CYP27B1, KRT1, TP63, SAT1, FGFR3
20sulindac44 1111.9SAT1, BCL2, PCNA
21eb 108944 5911.9CYP27B1, PCNA, BCL2
22thapsigargin44 5911.9ATP2A2, BCL2, PCNA, DSP
23dutp4410.9BCL2, KRT10, PCNA
24arsenite44 2411.9BCL2, SLURP1, PCNA, PIK3CA
25cisplatin44 49 59 1113.9BCL2, PCNA, SAT1, PIK3CA, TP63
26calcitriol44 59 11 2413.9TGFB2, CYP27B1, KRT10, GHR
27resveratrol44 59 11 2413.9TGFB2
28thymidine44 2411.9GHR, PIK3CA, PCNA, TGFB2, TP63
29isoleucine4410.9GHR, KRT10, KRT1
30naphtho(1,2-b)furan-4,5-dione4410.9PIK3CA, BCL2
31(r)-(+)-etomoxir sodium salt5910.8KFSD, SAT1
32ym 7505910.8SAT1, KFSD
33vulm 14575910.8KFSD, SAT1
34n1,n11-diethylnorspermine tetrahydrochloride5910.8KFSD, SAT1
35retinoid4410.8BCL2, KRT10, KRT1, CYP27B1
36cycloheximide4410.8TGFB2, SAT1, CYP27B1, GHR, BCL2
37cysteine4410.8CYP27B1, TGFB2, FGFR3, PCNA, GHR, CTSC
38eosin4410.8KRT10, PCNA
39a 9225005910.7KFSD, SAT1
40vitamin d4410.7CYP27B1, GHR, KRT10, TGFB2
41tazarotene44 1111.6KRT10, KRT1
421,25 dihydroxy vitamin d34410.5KRT10, CYP27B1, TGFB2
43adpribose4410.5BCL2, PCNA, PIK3CA
44mitomycin c4410.4TP63, BCL2, PCNA
45p0034410.2TGFB2, TP63, GHR

GO Terms for genes affiliated with Keratosis

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16Gene Ontology
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Biological processes related to Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hair follicle morphogenesisGO:03106910.6TGFB2, TP63, BCL2
2keratinocyte differentiationGO:03021610.6TP63, KRT10, DSP
3digestive tract morphogenesisGO:04854610.5BCL2, FGFR3
4cell-cell adhesionGO:01633710.4DSP, DSG1, BCL2
5negative regulation of anoikisGO:200081110.2BCL2, PIK3CA

Molecular functions related to Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.8TGFB2, CTSC, PIK3CA, ATP2A2, GHR, DSP

Products for genes affiliated with Keratosis

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Sources for Keratosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet