Aliases & Classifications for Keratosis

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Keratosis, Aliases & Descriptions:

Name: Keratosis 9 11 60
Actinic Keratosis 60
 
Hyperkeratosis 60


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Disease Ontology9 DOID:161
MeSH33 D007642
SNOMED-CT55 254666005
NCIt38 C34747

Summaries for Keratosis

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Wikipedia:63 Keratosis (from keratinocyte, the prominent cell type in the epidermis, and -osis, abnormal) is a growth... more...

MalaCards based summary: Keratosis, also known as actinic keratosis, is related to actinic keratosis and keratosis follicularis spinulosa decalvans, x-linked. An important gene associated with Keratosis is SAT1 (spermidine/spermine N1-acetyltransferase 1), and among its related pathways are Staphylococcus aureus infection and Antiarrhythmic Pathway, Pharmacodynamics. The drugs diclofenac and diclofenac potassium and the compounds tazarotene and isotretinoin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells, and related mouse phenotypes are reproductive system and tumorigenesis.

Related Diseases for Keratosis

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Diseases related to Keratosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 183)
idRelated DiseaseScoreTop Affiliating Genes
1actinic keratosis32.4TP63
2keratosis follicularis spinulosa decalvans, x-linked31.4SAT1
3palmoplantar keratosis31.3CTSC, DSG1
4lichen planus31.0KRT1, KRT10
5leukoplakia30.9KRT1
6darier disease30.9DSP, ATP2A2
7keratosis, seborrheic, somatic30.6PIK3CA, FGFR3
8keratoderma30.6KRT1, DSG1, DSP
9epidermolytic hyperkeratosis30.4KRT1, KRT10
10pemphigus30.3DSP, DSG1
11hailey-hailey disease30.2DSP, ATP2A2
12congenital ichthyosiform erythroderma30.2KRT10, KRT1
13melanoma30.1PIK3CA, TP63, DSG1, SAT1, FGFR3
14papilloma30.0TP63, KRT10, FGFR3
15bullous pemphigoid29.9DSG1, DSP
16palmoplantar keratoderma, nonepidermolytic29.7DSG1, KRT10, KRT1, CTSC
17retinoblastoma29.5FGFR3, KRT10, PIK3CA
18adenocarcinoma29.5PIK3CA, TP63, KRT10, KRT1, CTSC
19leukemia28.9PIK3CA, SAT1, KRT10, FGFR3
20breast cancer28.8PIK3CA, TP63, DSP, SAT1, FGFR3
21basal cell carcinoma10.7
22inverted follicular keratosis10.7
23epidermolytic acanthoma10.5KRT1
24blindness10.4
25leopard syndrome10.4DSP
26vulvar seborrheic keratosis10.4
27keratosis follicularis dwarfism and cerebral atrophy10.3
28keratosis palmoplantaris striata10.3
29ichthyosis, cyclic, with epidermolytic hyperkeratosis10.3KRT10, KRT1
30keratosis linearis with ichthyosis congenita and sclerosing keratoderma10.3
31epidermodysplasia verruciformis10.3
32keratosis palmoplantaris striata i, ad10.3
33alopecia10.3
34acanthoma10.3
35bowen syndrome10.3KRT10, KRT1
36epidermolysis bullosa simplex10.3KRT1, KRT10
37keratosis palmoplantaris striata ii10.2
38keratosis palmoplantaris striata iii10.2
39meleda disease10.2
40keratoacanthoma10.2
41psoriasis10.2
42alopecia congenita keratosis palmoplantaris10.2
43oral leukoplakia10.2KRT1, TP63
44inflamed seborrheic keratosis10.2
45keratosis focal palmoplantar gingival10.2
46astigmatism10.2FGFR3, CTSC
47cervical squamous cell carcinoma10.2KRT10, TP63
48haim-munk syndrome10.2
49palmoplantar keratoderma, epidermolytic10.2
50keratoderma, palmoplantar, punctate type ia10.2

Graphical network of the top 20 diseases related to Keratosis:



Diseases related to keratosis

Symptoms for Keratosis

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Drugs & Therapeutics for Keratosis

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Drug clinical trials:

Search ClinicalTrials for Keratosis

Search NIH Clinical Center for Keratosis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Keratosis

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Anatomical Context for Keratosis

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MalaCards organs/tissues related to Keratosis:

31
Skin, Breast, T cells, Colon, Liver, Testes, Kidney, Myeloid, Pituitary

Animal Models for Keratosis or affiliated genes

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MGI Mouse Phenotypes related to Keratosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.9FGFR3, SAT1, TP63, ATP2A2, PIK3CA
2MP:00020067.6PIK3CA, ATP2A2, TP63, SAT1, KRT10, FGFR3
3MP:00053877.1PIK3CA, ATP2A2, TP63, KRT10, KRT1, CTSC
4MP:00053767.0PIK3CA, ATP2A2, TP63, SAT1, KRT1, CTSC
5MP:00053847.0PIK3CA, ATP2A2, TP63, DSP, SAT1, CTSC
6MP:00107716.7FGFR3, PIK3CA, ATP2A2, TP63, DSP, KRT10
7MP:00107686.6PIK3CA, ATP2A2, TP63, DSP, KRT10, KRT1
8MP:00053786.4PIK3CA, ATP2A2, TP63, DSP, SAT1, KRT10

Publications for Keratosis

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Articles related to Keratosis:

(show top 50)    (show all 977)
idTitleAuthorsYear
1
A study of topical methyl-aminolaevulinate red-light photodynamic therapy in the treatment of actinic keratosis in Chinese patients: a Singaporean experience. (25800146)
2015
2
Digital microscopy of seborrheic keratosis. (25521392)
2015
3
Treatment of face and scalp solar (actinic) keratosis with daylight-mediated photodynamic therapy is possible throughout the year in Australia: Evidence from a clinical and meteorological study. (25827200)
2015
4
Reduced degree of irritation during a second cycle of ingenol mebutate gel 0.015% for the treatment of actinic keratosis. (25671445)
2015
5
In vivo Reflectance Confocal Microscopy Characterization of Field-Directed 5-Fluorouracil 0.5%/Salicylic Acid 10% in Actinic Keratosis. (25721522)
2015
6
Efficacy of imiquimod 3.75% from Lmax according to the number of actinic keratosis lesions. (25351284)
2014
7
Treatment of Keratosis Pilaris With 810-nm Diode Laser: Randomized Clinical Trial. (25372313)
2014
8
Highly prevalent SERPINB7 founder mutation causes pseudodominant inheritance pattern in Nagashima-type palmoplantar keratosis. (24773080)
2014
9
Epithelial Stem Cells of the Skin Contribute to the Histopathologic Umbrella-like Appearance in Actinic Keratosis. (25349467)
2014
10
Collision tumor of eccrine poroma, seborrheic keratosis, and a viral wart. (25526344)
2014
11
Inhibition of keratinocyte proliferation by phospholipid-conjugates of a TLR7 ligand in a Myc-induced hyperplastic actinic keratosis model in the absence of systemic side effects. (24225049)
2013
12
Current issues in the management of actinic keratosis. (23228304)
2013
13
Actinic keratosis underlying cutaneous horn at an unusual site-a case report. (24294287)
2013
14
Photodynamic therapy for actinic keratosis in organ transplant patients. (22151793)
2013
15
Photopneumatic therapy for the treatment of keratosis pilaris. (23884495)
2013
16
Microarray analysis reveals increased expression of I9Np63I+ in seborrhoeic keratosis. (21967648)
2012
17
Ingenol mebutate gel for actinic keratosis. (22417254)
2012
18
Topical 5-fluorouracil for the treatment of periocular actinic keratosis and low-grade squamous malignancy. (22460673)
2012
19
Longitudinal erythronychia with subungual keratosis: a daughter subungual nail. (22681540)
2012
20
Discrimination of squamous cell carcinoma in situ from seborrheic keratosis by color analysis techniques requires information from scale, scale-crust and surrounding areas in dermoscopy images. (23117020)
2012
21
Keratosis pilaris revisited: is it more than just a follicular keratosis? (23766609)
2012
22
Keratosis pilaris rubra and keratosis pilaris atrophicans faciei treated with pulsed dye laser: report of 10 cases. (20569297)
2011
23
Eyebrow reconstruction in dormant keratosis pilaris atrophicans. (21723799)
2011
24
Coexistent Dowling-Degos disease and reticulate acropigmentation of kitamura with progressive seborrheic keratosis. (21416772)
2011
25
Sebaceous carcinoma associated with seborrheic keratosis. (20868621)
2010
26
The keratin-14 expression in actinic keratosis and squamous cell carcinoma: is this a prognostic factor for tumor progression? (20622965)
2010
27
Actinic keratosis: facts and controversies. (20541675)
2010
28
Review ofactinic keratosis. Part I: etiology, epidemiology and clinical presentation. (20865846)
2010
29
Effectiveness of cross polarized light and fluorescence diagnosis for detection of sub-clinical and clinical actinic keratosis during imiquimod treatment. (20201959)
2010
30
Erosive pustular dermatosis of the scalp following treatment with topical imiquimod for actinic keratosis. (19917978)
2009
31
'Nagashima-type' keratosis palmoplantaris in two siblings. (19470072)
2009
32
Keratosis follicularis spinulosa decalvans in a family. (18280351)
2008
33
A dermatoscopically diagnosed collision tumour: malignant melanoma arising within a seborrhoeic keratosis. (18462448)
2008
34
Melanoma in-situ arising in seborrheic keratosis: a case report. (18947402)
2008
35
Variable pulsed light is less painful than light-emitting diodes for topical photodynamic therapy of actinic keratosis: a prospective randomized controlled trial. (17542980)
2007
36
The Delphi panel in the economic evaluation of photodynamic therapy for actinic keratosis and basal cell carcinoma: poor results? (17535242)
2007
37
Management of actinic keratosis patients: a qualitative study. (17365267)
2007
38
The diagnostic concordance of actinic keratosis and squamous cell carcinoma. (16965343)
2006
39
A case of follicular keratosis with trichostasis on an amputated limb. (16716178)
2006
40
Clinical diagnosis of actinic keratosis identifies an elderly population at high risk of developing skin cancer. (15720095)
2005
41
Inverted follicular keratosis simulating malignant melanoma. (14961911)
2004
42
From actinic keratosis to squamous cell carcinoma. (11966728)
2002
43
Gene dosage of the spermidine/spermine N(1)-acetyltransferase (SSAT) gene with putrescine accumulation in a patient with a Xp21.1p22.12 duplication and keratosis follicularis spinulosa decalvans (KFSD). (12215835)
2002
44
Molecular genetic analysis of two families with keratosis follicularis spinulosa decalvans: refinement of gene localization and evidence for genetic heterogeneity. (9341865)
1997
45
Identification of the genetic locus for keratosis palmaris et plantaris on chromosome 17 near the RARA and keratin type I genes. (7504553)
1993
46
Actinic keratosis: preventable and treatable like other precancerous and cancerous skin lesions. (2675146)
1989
47
POEMS syndrome associated with cryoglobulinemia, lymphoma, multiple seborrheic keratosis, and ichthyosis. (2848065)
1988
48
Inverted follicular keratosis is a distinct follicular tumor. (6660428)
1983
49
Actinic keratosis and telangiectasia. (5060883)
1972
50
Actinic Keratosis of the Left Forearm Due to Driving an Automobile. (18745405)
1939

Variations for Keratosis

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Expression for genes affiliated with Keratosis

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Search GEO for disease gene expression data for Keratosis.

Pathways for genes affiliated with Keratosis

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Pathways related to Keratosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6KRT10, DSG1
29.6ATP2A2, DSP
39.5DSP, KRT1
4
Show member pathways
9.5DSG1, DSP
5
Show member pathways
9.1DSP, PIK3CA
6
Show member pathways
9.0FGFR3, PIK3CA
7
Show member pathways
9.0FGFR3, PIK3CA
8
Show member pathways
9.0FGFR3, PIK3CA
98.5FGFR3, TP63, PIK3CA

Compounds for genes affiliated with Keratosis

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Compounds related to Keratosis according to GeneCards Suite gene sharing:

(show all 23)
idCompoundScoreTop Affiliating Genes
1tazarotene43 1210.9KRT1, KRT10
2isotretinoin43 1210.9KRT1, KRT10
3ryanodine43 28 5911.6DSP, ATP2A2
4isoleucine439.6KRT10, KRT1
5hematoxylin439.5KRT1, KRT10, TP63
6iodide43 2410.4KRT10, PIK3CA
7histidine439.3TP63, KRT10, CTSC
8proline439.1CTSC, KRT1, KRT10
9lysine438.9FGFR3, KRT1, SAT1, TP63
10paraffin438.8FGFR3, KRT1, KRT10, TP63
11dmso438.8PIK3CA, TP63, DSP
12bromodeoxyuridine438.7PIK3CA, TP63, KRT10, KRT1
13doxorubicin43 49 1210.5FGFR3, TP63, PIK3CA
14threonine438.4PIK3CA, KRT10, KRT1, FGFR3
15estrogen438.3PIK3CA, TP63, SAT1, KRT10, KRT1
16progesterone43 28 59 24 1212.1PIK3CA, TP63, DSP, KRT10, KRT1
17steroid438.1PIK3CA, TP63, DSP, KRT10, KRT1
18glutamate438.0PIK3CA, TP63, KRT10, KRT1, FGFR3
19retinoic acid43 248.7PIK3CA, TP63, DSP, DSG1, KRT10, KRT1
20tyrosine437.5PIK3CA, TP63, DSP, KRT10, KRT1, FGFR3
21arginine437.5PIK3CA, TP63, SAT1, KRT10, KRT1, CTSC
22calcium43 49 24 129.7PIK3CA, ATP2A2, TP63, DSP, DSG1, KRT10
23serine436.7FGFR3, PIK3CA, ATP2A2, DSP, DSG1, SAT1

GO Terms for genes affiliated with Keratosis

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Cellular components related to Keratosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic side of plasma membraneGO:00098989.4FGFR3, DSG1
2desmosomeGO:00300579.2DSG1, DSP

Biological processes related to Keratosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular component disassembly involved in execution phase of apoptosisGO:00069219.5DSG1, DSP
2positive regulation of apoptotic signaling pathwayGO:020012359.3CTSC, TP63
3keratinocyte differentiationGO:00302169.0KRT10, DSP, TP63

Molecular functions related to Keratosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055156.6FGFR3, CTSC, KRT1, SAT1, DSP, TP63

Products for genes affiliated with Keratosis

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Sources for Keratosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet