MCID: KRT009
MIFTS: 53

Keratosis malady

Summaries for Keratosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Keratosis (from: keratinocyte, the prominent cell type in the epidermis and -osis, abnormal) a growth of... more...

MalaCards: Keratosis, also known as hyperkeratosis, is related to actinic keratosis and seborrheic keratosis. An important gene associated with Keratosis is SAT1 (spermidine/spermine N1-acetyltransferase 1), and among its related pathways are MicroRNAs in cancer and Pathways in cancer. The compounds serine and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and colon, and related mouse phenotypes are growth/size and immune system.

Aliases & Classifications for Keratosis

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

keratosis 8 10
hyperkeratosis 60


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Disease Ontology8 DOID:161
NCIt39 C34747
SNOMED-CT56 254666005
MeSH34 D007642

Related Diseases for Keratosis

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17GeneCards, 18GeneDecks
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Diseases related to Keratosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 408)
idRelated DiseaseScoreTop Affiliating Genes
1actinic keratosis31.7TP63, CYP27B1, PCNA, GHR
2seborrheic keratosis31.5PIK3CA, FGFR3
3squamous cell carcinoma31.1PIK3CA, ATP2A2, GHR, DSP, DSG1, PCNA
4keratosis follicularis31.0ATP2A2, MBTPS2, SAT1
5basal cell carcinoma31.0TP63, BCL2, KRT10, CYP27B1
6melanoma30.8SAT1, PIK3CA, GHR, DSG1, PCNA, CYP27B1
7palmoplantar keratosis30.7CTSC, DSG1, SLURP1
8lichen planus30.6KRT10, KRT1
9keratosis follicularis spinulosa decalvans30.4KFSD, SAT1
10alopecia30.3MBTPS2
11keratoacanthoma30.3KRT10, PCNA
12mongolian spot30.3DSP, ATP2A2
13epidermolysis bullosa simplex30.2KRT10, KRT1
14skin disease30.2ATP2A2, DSP, DSG1, FGFR3, SLURP1, KRT1
15psoriasis30.2CYP27B1, KRT1, KRT10
16adenocarcinoma30.0CTSC, PIK3CA, GHR, PCNA, CYP27B1, KRT1
17cholesteatoma30.0KRT10
18nonepidermolytic palmoplantar keratoderma30.0CTSC, DSG1, KRT1, KRT10
19ichthyosis, cyclic, with epidermolytic hyperkeratosis30.0KRT1, KRT10
20retinoblastoma29.9PIK3CA, PCNA, FGFR3, KRT10, BCL2, TGFB2
21papilloma29.9TP63, KRT10, FGFR3, PCNA
22leukoplakia29.9PCNA, KRT1
23epidermolytic hyperkeratosis29.9KRT1, KRT10
24osteosarcoma29.7TGFB2, CYP27B1, GHR
25epidermolysis bullosa29.7DSP
26hailey-hailey disease29.7DSP, ATP2A2
27breast cancer29.7SAT1, PIK3CA, DSP, PCNA, CYP27B1, FGFR3
28amyloidosis29.7KRT10
29sarcoma29.6DSP, DSG1, TP63
30inverted follicular keratosis10.6
31skin squamous cell carcinoma10.4
32in situ carcinoma10.4
33acanthoma10.2
34alopecia congenita keratosis palmoplantaris10.2
35hyperkeratosis lenticularis perstans10.2
36inflamed seborrheic keratosis10.2
37epidermodysplasia verruciformis10.2
38vulvar seborrheic keratosis10.2
39keratosis follicularis dwarfism and cerebral atrophy10.2
40keratosis palmoplantaris striata i, ad10.2
41keratosis follicularis spinulosa decalvans, x-linked10.2
42keratosis pilaris atrophicans10.2
43skin melanoma10.1
44keratosis palmoplantaris striata 310.1
45keratoderma palmoplantar deafness10.1
46hyperkeratosis-hyperpigmentation syndrome10.1
47acquired hyperkeratosis10.1
48verrucous carcinoma10.1
49keratosis palmoplantaris papulosa10.1
50keratosis focal palmoplantar gingival10.1

Graphical network of the top 20 diseases related to Keratosis:



Diseases related to keratosis

Clinical Features for Keratosis

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Drugs & Therapeutics for Keratosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Keratosis

Search NIH Clinical Center for Keratosis

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Genetic Tests for Keratosis

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Anatomical Context for Keratosis

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32MalaCards
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MalaCards organs/tissues related to Keratosis:

32
Skin, Breast, Colon, Liver, Testes, T cells, Kidney, Myeloid

Animal Models for Keratosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Keratosis:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537811.0TGFB2, SAT1, CTSC, PIK3CA, ATP2A2, GHR
2MP:000538710.9GHR, ATP2A2, PIK3CA, CTSC, PCNA, CYP27B1
3MP:000538910.9SAT1, PIK3CA, ATP2A2, GHR, PCNA, CYP27B1
4MP:000538410.9ATP2A2, PIK3CA, CTSC, SAT1, DSP, PCNA
5MP:001077110.8CTSC, PIK3CA, ATP2A2, CYP27B1, KRT1, BCL2
6MP:000200610.8SAT1, PIK3CA, ATP2A2, FGFR3, KRT10, BCL2
7MP:000537610.7CTSC, PIK3CA, ATP2A2, GHR, CYP27B1, FGFR3
8MP:000536710.6ATP2A2, GHR, CYP27B1, FGFR3, BCL2, TP63
9MP:001076810.6PIK3CA, ATP2A2, GHR, DSP, PCNA, FGFR3
10MP:000537510.5GHR, SAT1
11MP:000537910.3PIK3CA, GHR, CYP27B1, BCL2

Publications for Keratosis

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50PubMed
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Articles related to Keratosis:

(show top 50)    (show all 907)
idTitleAuthorsYear
1
Photodynamic therapy for actinic keratosis in organ transplant patients. (22151793)
2013
2
Dermatoscopy of facial non-pigmented actinic keratosis regarding to grades of the lesions. (23094862)
2013
3
Dermal changes in superficial basal cell carcinoma, melanoma in situ and actinic keratosis and their implications. (24117926)
2013
4
Long-pulsed 1064-nm Nd:YAG laser significantly improves keratosis pilaris: a randomized, evaluator-blind study. (22268726)
2013
5
Keratosis lichenoides chronica masquerading as discoid lupus erythematosus. (23517367)
2013
6
Ingenol mebutate: A novel topical drug for actinic keratosis. (23984250)
2013
7
Topical photodynamic therapy with methylaminolevulinate for the treatment of actinic keratosis and reduction of photodamage in organ transplant recipients: a case-series of 16 patients. (22772615)
2012
8
Atypical nail dystrophy in a possible case of Nagashima-type palmoplantar keratosis. (21950725)
2012
9
Mutational analysis of cutaneous squamous cell carcinomas and verrucal keratosis in patients taking BRAF inhibitors. (22726224)
2012
10
MBTPS2 mutation in a British pedigree with keratosis follicularis spinulosa decalvans. (22816986)
2012
11
The effect of increasing fluence on the treatment of actinic keratosis and photodamage by photodynamic therapy with 5-aminolevulinic acid and intense pulsed light. (21631378)
2011
12
Keratosis pilaris atrophicans: treatment with intense pulsed light in four patients. (20590370)
2010
13
Seborrheic keratosis or verruca plana? A pilot study with confocal laser scanning microscopy. (21039905)
2010
14
Actinic keratosis: treat lesions to reduce cancer risk. (20128199)
2010
15
Diagnostic pitfalls of using dermoscopic features to differentiate between malignant melanoma and pigmented seborrhoeic keratosis. (20574625)
2010
16
Viral DNA detection and RAS mutations in actinic keratosis and nonmelanoma skin cancers. (19849697)
2010
17
A case of lymphomatoid keratosis. (20548920)
2010
18
Plantar epidermoid inclusion cyst as a possible cause of intractable plantar keratosis lesions. (19299353)
2009
19
Predisposing factors of actinic keratosis in a North-West German population. (19470418)
2009
20
Seborrheic keratosis that follows Blaschko's lines. (18477232)
2008
21
Successful cochlear implantation in a child with Keratosis, Icthiosis and Deafness (KID) Syndrome and Dandy-Walker malformation. (18313767)
2008
22
Keratosis pilaris: a common follicular hyperkeratosis. (18856156)
2008
23
Aminolevulinic acid 585 nm pulsed dye laser photodynamic treatment of laryngeal keratosis with atypia. (17547974)
2007
24
Psoriasiform keratosis: a lesion mimicking psoriasis. (17890921)
2007
25
The nature of solar (actinic) keratosis. (17223905)
2007
26
Neglected keratosis obturans causing facial nerve palsy. (16939670)
2006
27
Focal palmoplantar and gingival keratosis: a distinct palmoplantar ectodermal dysplasia with epidermolytic alterations but lack of mutations in known keratins. (15761417)
2005
28
Imiquimod 5% cream for the treatment of actinic keratosis: results from a phase III, randomized, double-blind, vehicle-controlled, clinical trial with histology. (15389189)
2004
29
The development of actinic keratosis into invasive squamous cell carcinoma: evidence and evolving classification schemes. (15262304)
2004
30
Human papillomavirus infection in actinic keratosis and bowen's disease: comparative study with expression of cell-cycle regulatory proteins p21(Waf1/Cip1), p53, PCNA, Ki-67, and Bcl-2 in positive and negative lesions. (14562284)
2003
31
The use of topical fluorouracil to treat actinic keratosis. (12353679)
2002
32
Ultraviolet light downregulates CD95 ligand and TRAIL receptor expression facilitating actinic keratosis and squamous cell carcinoma formation. (11442750)
2001
33
Association analysis of somatostatin receptor (SSTR1 and SSTR2) polymorphisms in breast cancer and solar keratosis. (11311492)
2001
34
Testing your diagnostic skills (#53). Case 1: Cheilitis glandularis apostematosa. Actinic keratosis (cheilitis). (11545062)
2001
35
Apoptosis in the areas of squamous differentiation of irritated seborrheic keratosis. (10728813)
2000
36
Seborrheic keratosis of conjunctiva simulating a malignant melanoma: an immunocytochemical study with impression cytology. (10442897)
1999
37
A case of seborrheic keratosis distributed along skin cleavage lines. (9609989)
1998
38
Epidermolytic hyperkeratosis of the nails in keratosis palmoplantaris nummularis. (8615066)
1995
39
Seborrheic keratosis-like lesions in epidermodysplasia verruciformis. (8396161)
1993
40
Simple epithelial cytokeratin-expression in seborrheic keratosis. (1282137)
1992
41
Adenocarcinoma arising in a seborrheic keratosis. (1835342)
1991
42
Abnormalities of keratinocyte maturation and differentiation in keratosis palmoplantaris striata. Immunohistochemical and ultrastructural study before and during etretinate therapy. (1693821)
1990
43
Seborrheic keratosis with possible central regression. (2529103)
1989
44
A syndrome of keratosis palmo-plantaris congenita, pes planus, onychogryphosis, periodontosis, arachnodactyly and a peculiar acro-osteolysis. (2943312)
1986
45
Malignant melanoma appearing in seborrheic keratosis. (6232304)
1984
46
Inverted follicular keratosis and verruca vulgaris. An investigation for the papillomavirus common antigen. (6330188)
1984
47
Inverted follicular keratosis is a distinct follicular tumor. (6660428)
1983
48
Pilar acanthoma: a combination of inverted follicular keratosis and sebaceous trichofolliculoma. (7037900)
1981
49
Inverted follicular keratosis. (453311)
1979
50
The inverted follicular keratosis. A surprising variant of seborrheic wart. (78617)
1976

Genetic Variations for Keratosis

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Expression for genes affiliated with Keratosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratosis

Search GEO for disease gene expression data for Keratosis.

Pathways for genes affiliated with Keratosis

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29KEGG, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems
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Pathways related to Keratosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.6TP63, BCL2, FGFR3, PIK3CA
210.6TGFB2, BCL2, FGFR3, PIK3CA
310.5GHR, FGFR3, TGFB2
410.5DSG1, DSP
510.5TGFB2, BCL2

Compounds for genes affiliated with Keratosis

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Keratosis according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1serine4411.2GHR, ATP2A2, PIK3CA, CTSC, SAT1, DSP
2retinoic acid44 2412.2PIK3CA, GHR, DSP, DSG1, PCNA, CYP27B1
3calcium44 49 11 2414.1PIK3CA, ATP2A2, DSP, DSG1, CYP27B1, FGFR3
4arginine4411.1SAT1, CTSC, PIK3CA, GHR, PCNA, FGFR3
5paraffin4411.1TGFB2, GHR, PCNA, CYP27B1, FGFR3, KRT1
6progesterone44 59 28 11 2415.1PIK3CA, GHR, DSP, PCNA, KRT1, KRT10
7steroid4411.1PIK3CA, GHR, DSP, CYP27B1, SLURP1, KRT1
8tyrosine4411.1PIK3CA, GHR, DSP, CYP27B1, FGFR3, KRT1
9testosterone44 59 11 2414.1PIK3CA, GHR, PCNA, CYP27B1, SLURP1, KRT1
10bromodeoxyuridine4411.0PIK3CA, PCNA, KRT1, KRT10, TP63, TGFB2
11histidine4411.0CTSC, GHR, KRT10, TP63, TGFB2
125fluorouracil4411.0SAT1, PIK3CA, PCNA, BCL2, TGFB2
13hematoxylin4411.0PCNA, KRT1, KRT10, TP63
14oligonucleotide4411.0GHR, PCNA, CYP27B1, FGFR3, BCL2, TGFB2
15tamoxifen44 49 28 1114.0PIK3CA, GHR, PCNA, BCL2, TGFB2
16dexamethasone44 49 28 1114.0TGFB2, BCL2, PCNA, PIK3CA
17vegf4411.0PIK3CA, PCNA, FGFR3, BCL2, TP63, TGFB2
18genistein44 28 59 2 11 2415.9PIK3CA, PCNA, CYP27B1, BCL2, TGFB2
19lysine4410.9SAT1, CYP27B1, FGFR3, KRT1, TP63
20sulindac44 1111.9SAT1, PCNA, BCL2
21eb 108944 5911.9BCL2, CYP27B1, PCNA
22thapsigargin44 5911.9ATP2A2, DSP, PCNA, BCL2
23dutp4410.9PCNA, KRT10, BCL2
24arsenite44 2411.9PIK3CA, PCNA, SLURP1, BCL2
25cisplatin44 49 59 1113.9SAT1, PIK3CA, PCNA, BCL2, TP63
26calcitriol44 59 11 2413.9GHR, CYP27B1, KRT10, TGFB2
27resveratrol44 59 11 2413.9TGFB2
28thymidine44 2411.9PIK3CA, GHR, PCNA, TP63, TGFB2
29isoleucine4410.9KRT10, KRT1, GHR
30naphtho(1,2-b)furan-4,5-dione4410.9BCL2, PIK3CA
31vulm 14575910.8SAT1, KFSD
32ym 7505910.8SAT1, KFSD
33n1,n11-diethylnorspermine tetrahydrochloride5910.8SAT1, KFSD
34a 9225005910.8SAT1, KFSD
35retinoid4410.8CYP27B1, KRT1, KRT10, BCL2
36cycloheximide4410.8SAT1, GHR, CYP27B1, BCL2, TGFB2
37(r)-(+)-etomoxir sodium salt5910.8SAT1, KFSD
38cysteine4410.8CTSC, GHR, PCNA, CYP27B1, FGFR3, TGFB2
39eosin4410.7PCNA, KRT10
40vitamin d4410.7TGFB2, KRT10, CYP27B1, GHR
41tazarotene44 1111.6KRT1, KRT10
421,25 dihydroxy vitamin d34410.5TGFB2, KRT10, CYP27B1
43adpribose4410.5BCL2, PCNA, PIK3CA
44mitomycin c4410.4PCNA, BCL2, TP63
45p0034410.2TGFB2, TP63, GHR

GO Terms for genes affiliated with Keratosis

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16Gene Ontology
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Biological processes related to Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hair follicle morphogenesisGO:03106910.6TGFB2, TP63, BCL2
2keratinocyte differentiationGO:03021610.6TP63, KRT10, DSP
3digestive tract morphogenesisGO:04854610.5BCL2, FGFR3
4cell-cell adhesionGO:01633710.4DSP, DSG1, BCL2
5negative regulation of anoikisGO:200081110.2BCL2, PIK3CA

Molecular functions related to Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.8TGFB2, CTSC, PIK3CA, ATP2A2, GHR, DSP

Products for genes affiliated with Keratosis

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  • Antibodies
  • Proteins
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Sources for Keratosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet