Aliases & Classifications for Keratosis

MalaCards integrated aliases for Keratosis:

Name: Keratosis 12 42 14 69
Actinic Keratosis 69
Hyperkeratosis 69

Classifications:



External Ids:

Disease Ontology 12 DOID:161
MeSH 42 D007642
NCIt 47 C34747
SNOMED-CT 64 254666005
UMLS 69 C0022593

Summaries for Keratosis

Disease Ontology : 12 A skin disease characterized_by growth of keratin on the skin or mucous membranes.

MalaCards based summary : Keratosis, also known as actinic keratosis, is related to keratosis palmoplantaris striata iii and squamous cell carcinoma, and has symptoms including exanthema, pruritus and trichorrhexis invaginata. An important gene associated with Keratosis is MBTPS2 (Membrane Bound Transcription Factor Peptidase, Site 2), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Imiquimod and Aminolevulinic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and kidney, and related phenotypes are cellular and growth/size/body region

Wikipedia : 72 Keratosis (from keratinocyte, the prominent cell type in the epidermis, and -osis, abnormal) is a growth... more...

Related Diseases for Keratosis

Diseases related to Keratosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 239)
id Related Disease Score Top Affiliating Genes
1 keratosis palmoplantaris striata iii 32.4 KRT1 KRT17 KRT9
2 squamous cell carcinoma 30.9 KRT1 KRT10 KRT9
3 actinic keratosis 12.3
4 keratosis pilaris atrophicans 12.2
5 keratosis, seborrheic, somatic 12.2
6 palmoplantar keratosis 12.2
7 keratosis follicularis spinulosa decalvans 12.2
8 inverted follicular keratosis 12.1
9 keratosis linearis with ichthyosis congenita and sclerosing keratoderma 12.1
10 keratosis follicularis spinulosa decalvans, x-linked 12.0
11 keratosis follicularis, dwarfism, and cerebral atrophy 12.0
12 vulvar seborrheic keratosis 11.9
13 inflamed seborrheic keratosis 11.8
14 keratosis palmoplantaris striata i, ad 11.8
15 keratosis palmoplantaris striata ii 11.8
16 darier disease 11.7
17 keratosis palmaris et plantaris with clinodactyly 11.7
18 keratosis palmoplantaris adenocarcinoma of the colon 11.6
19 keratosis, focal palmoplantar and gingival 11.6
20 circumscribed disseminated keratosis jadassohn lew type 11.6
21 vulvar inverted follicular keratosis 11.6
22 papillon-lefevre syndrome 11.5
23 meleda disease 11.5
24 erythrokeratodermia variabilis et progressiva 1 11.4
25 keratoderma, palmoplantar, punctate type ia 11.4
26 tyrosinemia, type ii 11.4
27 haim-munk syndrome 11.4
28 focal palmoplantar and gingival keratoderma 11.3
29 punctate palmoplantar keratoderma 11.2
30 epidermodysplasia verruciformis 11.0
31 cholesteatoma 11.0
32 tylosis with esophageal cancer 11.0
33 ichthyosis vulgaris 11.0
34 melanoacanthoma 11.0
35 cole disease 11.0
36 naxos disease 10.9
37 palmoplantar keratoderma, epidermolytic 10.9
38 burnett schwartz berberian syndrome 10.9
39 striate palmoplantar keratoderma 10.9
40 bustos simosa pinto cisternas syndrome 10.8 FLG LRP1
41 palmoplantar keratoderma, nonepidermolytic 10.8
42 palmoplantar keratoderma, nagashima type 10.8
43 actinic cheilitis 10.8
44 phototoxic dermatitis 10.8 FGFR3 PIK3CA
45 schopf-schulz-passarge syndrome 10.8
46 keratoderma palmoplantaris transgrediens 10.8
47 epidermal nevus, somatic 10.8 FGFR3 PIK3CA
48 autism x-linked 4 10.7 MBTPS2 SAT1
49 glycogen storage disease due to lactate dehydrogenase deficiency 10.7 PIK3CA TP53
50 kidney cancer, childhood 10.7 LRP1 MBTPS2 SAT1

Comorbidity relations with Keratosis via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Keratosis, Seborrheic, Somatic

Graphical network of the top 20 diseases related to Keratosis:



Diseases related to Keratosis

Symptoms & Phenotypes for Keratosis

UMLS symptoms related to Keratosis:


exanthema, pruritus, trichorrhexis invaginata

MGI Mouse Phenotypes related to Keratosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.9 ATP2A2 CDKN2A CTSC FGFR3 GJB2 KRT17
2 growth/size/body region MP:0005378 9.73 FGFR3 GJB2 KRT1 KRT17 LRP1 PIK3CA
3 integument MP:0010771 9.32 ATP2A2 CDKN2A CTSC FGFR3 GJB2 KRT1

Drugs & Therapeutics for Keratosis

Drugs for Keratosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 204)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 99011-02-6 57469
2
Aminolevulinic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 106-60-5 137
3
Fluorouracil Approved Phase 4,Phase 3,Early Phase 1 51-21-8 3385
4
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 1 15307-86-5 3033
5
Alginic acid Approved, Experimental Phase 4 9005-32-7
6
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
7
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
8
Ethanol Approved Phase 4,Phase 2 64-17-5 702
9
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
10
Bezafibrate Approved Phase 4 41859-67-0 39042
11
Petrolatum Approved Phase 4,Phase 2,Early Phase 1 8009-03-8
12
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
13
Salicylic acid Approved, Vet_approved Phase 4,Phase 3,Phase 2 69-72-7 338
14
Tacrolimus Approved, Investigational Phase 4,Phase 1,Phase 2 104987-11-3 445643 439492
15
Everolimus Approved Phase 4,Phase 1,Phase 2 159351-69-6 6442177
16
Sirolimus Approved, Investigational Phase 4,Phase 1,Phase 2 53123-88-9 5284616 6436030 46835353
17
Menthol Approved Phase 4 2216-51-5 16666
18
Azathioprine Approved Phase 4 446-86-6 2265
19
Mycophenolate mofetil Approved, Investigational Phase 4 128794-94-5 5281078
20
Mycophenolic acid Approved Phase 4 24280-93-1 446541
21
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 11103-57-4, 68-26-8 445354
22
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
23
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 1 50-14-6 5280793
24
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 1 1406-16-2
25
Clobetasol Investigational Phase 4 25122-46-7, 25122-41-2 32798 5311051
26 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2,Phase 1
27 Interferon Inducers Phase 4,Phase 3,Phase 2,Phase 1
28 interferons Phase 4,Phase 3,Phase 2,Phase 1
29 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
30 Protective Agents Phase 4,Phase 3,Phase 2
31 Radiation-Protective Agents Phase 4,Phase 2
32 Sunscreening Agents Phase 4,Phase 3,Phase 2
33 Methyl 5-aminolevulinate Phase 4,Phase 3,Phase 2,Phase 1
34 Photosensitizing Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
35 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
36 Antimetabolites Phase 4,Phase 3,Phase 2,Early Phase 1
37 Antimetabolites, Antineoplastic Phase 4,Phase 3,Early Phase 1
38 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
39 Hormone Antagonists Phase 4,Phase 2,Phase 3
40 Hormones Phase 4,Phase 2,Phase 3
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
42 Anticholesteremic Agents Phase 4,Phase 2
43 Hypolipidemic Agents Phase 4,Phase 2
44 Lipid Regulating Agents Phase 4,Phase 2
45 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
46 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
47 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
48 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
49 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1
50 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 342)

id Name Status NCT ID Phase Drugs
1 Imiquimod 3.75% Cream in Combination With Cryotherapy in the Treatment of Hypertrophic Actinic Keratoses Unknown status NCT01229319 Phase 4 Cryotherapy alone to Left arm plus cryotherapy + imiquimod to Right arm;Cryotherapy alone to Left arm plus cryotherapy + imiquimod to Right arm
2 Long Term Efficacy and Safety of Eryfotona AK-NMSC® in Patients With Actinic Keratosis Unknown status NCT01656226 Phase 4
3 Potential Effect of Topical Imiquimod on Atrial Ectopy in Patients With Actinic Keratosis Unknown status NCT01413763 Phase 4 Imiquimod cream 3.75%;Placebo cream
4 Evaluate the Efficacy and Safety of Large-Scale Field-Directed Topical Therapy of Actinic Keratosis of the Chest w/Ingenol Mebutate 0.015% Completed NCT02446223 Phase 4 Inggenol Mebutate 0.015%
5 Open-Label Safety Study to Evaluate Imiquimod Cream, 5% for Large Areas of Actinic Keratosis Completed NCT00116649 Phase 4 imiquimod cream
6 Topical Imiquimod Cream in Combination With Cryotherapy for the Treatment of Actinic Keratoses Completed NCT00774787 Phase 4 imiquimod 5% cream
7 Clinical Trial of Ingenol Mebutate Gel 0.015% & 0.05% in Actinic Keratosis Completed NCT02716714 Phase 4 ingenol mebutate gel 0.015%;ingenol mebutate gel 0.05%
8 Study of Imiquimod 5% Cream in Addition to Cryotherapy in the Management of Actinic Keratoses Completed NCT00110682 Phase 4 Imiquimod used as an adjunct to cryotherapy
9 Study to Assess the Safety and Efficacy of Imiquimod 5% Cream for the Treatment of Actinic Keratosis on the Arms and Hands Completed NCT00115154 Phase 4 Aldara (imiquimod) cream, 5%
10 Gene Expression in Renal Transplant Patients With Field Actinic Keratosis Undergoing Metvix® Photodynamic Therapy (PDT) Completed NCT01000636 Phase 4
11 Long-term Effects of Imiquimod and Diclofenac in Actinic Keratoses Completed NCT00777127 Phase 4 Imiquimod;Diclofenac
12 Long-term Effects of Imiquimod and Diclofenac in Actinic Keratoses (LEIDA 2) Completed NCT01453179 Phase 4 Imiquimod;Diclofenac
13 An Open-Label 18-Month Safety Study of Fluorouracil Cream 0.5% for the Treatment of Actinic Keratoses Completed NCT00377273 Phase 4 fluorouracil cream 0.5%
14 Comparison of the Efficacy and Tolerability of Solaraze for 3 Versus 6 Months in Patients With Mild to Moderate Actinic Keratosis Located on the Face and Head Completed NCT00204542 Phase 4 Diclofenac;Diclofenac
15 Clinical Trial to Evaluate Biafine Cream Versus Standard Care in Subjects With Actinic Keratosis Post Cryotherapy Completed NCT00695578 Phase 4 Biafine
16 Safety and Efficacy of Ingenol Mebutate 0.05% Gel When Used After Cryotherapy in the Hypertrophic Actinic Keratoses Completed NCT02251652 Phase 4 Ingenol Mebutate
17 Effects of Topical Diclofenac on Tumor Metabolism Completed NCT01935531 Phase 4 3% diclofenac in 2.5% hyaluronic acid gel
18 Bilateral Comparison of Treatment of Facial Actinic Keratoses Using Microneedling and Photodynamic Therapy With Aminolevulinic Acid and Blue Light Versus Photodynamic Therapy With Aminolevulinic Acid and Blue Light Using Two Incubation Times Completed NCT02622594 Phase 4 Aminolevulinic Acid (ALA)
19 Efficacy and Safety of Ingenol Mebutate Gel 0.015% Compared to Diclofenac Sodium Gel 3% in Subjects With Actinic Keratoses on the Face or Scalp Completed NCT02406014 Phase 4 Ingenol Mebutate Gel, 0.015%;Diclofenac sodium gel 3%
20 Measuring Adherence To Topical 5-Fluorouracil in a Clinic Population Completed NCT00696488 Phase 4 Fluorouracil 0.5%
21 Daylight-PDT for AKs: Comparing Two Photosensitizers (BF-200 ALA and MAL) Completed NCT01893203 Phase 4 BF-200 ALA cream;MAL cream
22 Zurich Multiple Endpoint Vitamin D Trial in Knee OA Patients Completed NCT00599807 Phase 4
23 Comparison of Efficacy of Intralesional Triamcinolone Injection and Clobetasol Propionate Ointment for Psoriatic Nails Completed NCT01703325 Phase 4 0.1% triamcinolone , 0.05% clobetasol propionate ointment
24 The Effect of Fibrate Therapy in Two Patients With Neutral Lipid Storage Disease With Myopathy (NLSDM) Completed NCT01527318 Phase 4 Fibrate treatment
25 Efficacy and Safety of Treatment of Actinic Keratoses With Photodynamic Therapy Between MAL Cream and ALA Gel Recruiting NCT02647151 Phase 4 METHYLAMINOLEVULINATE HYDROCHLORIDE;AMINOLEVULINIC ACID HYDROCHLORIDE
26 Efficacy of Ingenol Mebutate on Actinic Keratoses and Field Cancerization vs Cryotherapy Recruiting NCT02990221 Phase 4 Ingenol mebutate
27 IM Versus 5-FU Versus IMI Versus MAL-PDT in Treatment of Actinic Keratosis Recruiting NCT02281682 Phase 4 Imiquimod;5-fluorouracil;Ingenol mebutate
28 Evaluating Skin Appearance Following 5-Flourouracil Cream for Treatment of Actinic Keratosis and the Effects of Topical Agents Recruiting NCT03279328 Phase 4 Topical Steroid Ointment;Skin Barrier Moisturier
29 Safety and Efficacy of Ingenol Mebutate Gel 0.015% for Treatment of AK on the Face in Solid Organ Transplant Recipients Recruiting NCT02866695 Phase 4 ingenol mebutate gel 0.015%
30 Daylight PDT for Actinic Keratoses: a Multicentre Study Comparing Two Photosensitizers (BF-200 ALA Versus MAL) Active, not recruiting NCT02464709 Phase 4 Aminolevulinic Acid;Methyl 5-aminolevulinate
31 Daylight-PDT With MAL for AK and Photodamaged Skin Active, not recruiting NCT02736760 Phase 4 Daylight photodynamic therapy using Methylaminolevulinate (MAL)
32 Risk of Squamous Cell Carcinoma on Skin Areas Treated With Ingenol Mebutate Gel, 0.015% and Imiquimod Cream, 5% Active, not recruiting NCT01926496 Phase 4 Ingenol Mebutate Gel, 0.015%;Imiquimod Cream, 5%
33 Menthol for PDT Pain Not yet recruiting NCT02984072 Phase 4 Menthol;Aqueous Cream
34 Imiquimod Versus Photodynamic Therapy of Actinic Keratoses in Organ Transplant Recipients Terminated NCT01538901 Phase 4 imiquimod 5% cream
35 Treatment of Actinic Keratoses of the Face With Imiquimod 3.75% Cream Followed by Photodynamic Therapy Terminated NCT01203878 Phase 4 Photodynamic therapy;Imiquimod
36 Efficacy and Safety of Salkera Emollient Foam in the Treatment of Moderate to Severe Keratosis Pilaris, a Prospective Study Terminated NCT00944216 Phase 4 Salkera Emollient Foam
37 Prevention of Skin Cancer in High Risk Patients After Conversion to a Sirolimus-based Immunosuppressive Protocol Terminated NCT00866684 Phase 4 Sirolimus;Azathioprine;Mycophenolate;Ciclosporin;Tacrolimus
38 Prevention of Skin Cancer in High Risk Patients After Conversion to a Sirolimus-based Immunosuppressive Protocol Terminated NCT01797315 Phase 4 Sirolimus
39 Actinic Keratoses Treatment With Metvix® in Combination With Light Unknown status NCT02373371 Phase 3 Metvix®
40 T4N5 Liposome Lotion Compared With Placebo Lotion for Preventing Actinic Keratoses in Patients With Xeroderma Pigmentosum Unknown status NCT00002811 Phase 3 liposomal T4N5 lotion
41 5fluorouracil for Advanced Photoaging Unknown status NCT01405144 Phase 3 5-fluoruracil
42 A Study of the Clinicopathologic Behaviour of the Different Types of Unsafe Chronic Otitis Media Unknown status NCT00270660 Phase 3
43 Treatment of the Recessive Nonbullous Congenital Ichthyosis by the Epigallocatechine Cutaneous Unknown status NCT01222000 Phase 3 apply VEREGEN ® 10 % on a randomized area and the moisturizing cream of the other side;apply VEREGEN ® 10 % on a randomized area and the moisturizing cream of the other side
44 A Multicenter Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel When Used to Treat Actinic Keratoses (AKs) on the Non Head Locations Completed NCT00742391 Phase 3 PEP005 (ingenol mebutate) Gel;Vehicle gel
45 A Multicenter Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel When Used to Treat Actinic Keratoses (AKs) on the Non Head Locations Completed NCT00942604 Phase 3 PEP005 (ingenol mebutate) Gel;Vehicle gel
46 Comparison Between 5-aminolevulinic Acid Photodynamic Therapy Versus Cryotherapy for Actinic Keratosis Treatment Completed NCT01459393 Phase 3 5-ALA Photodynamic Therapy;Cryotherapy with liquid nitrogen
47 A Multi-Center Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel, When Used to Treat Actinic Keratoses on the Head (Face or Scalp) Completed NCT00915551 Phase 3 PEP005 (Ingenol Mebutate) gel, 0.015%;Vehicle Gel
48 A Multi-center Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel, When Used to Treat Actinic Keratoses on the Head (Face or Scalp) Completed NCT00916006 Phase 3 PEP005 Gel;Vehicle gel
49 Metvix PDT Versus Vehicle PDT With Aktilite CL128 Lamp in Patients With Actinic Keratosis on the Face and Scalp Completed NCT00304239 Phase 3
50 Metvix PDT Versus Vehicle PDT With Aktilite CL128 Lamp in Patients With Actinic Keratosis on the Face and Scalp Completed NCT00306800 Phase 3

Search NIH Clinical Center for Keratosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: keratosis

Genetic Tests for Keratosis

Anatomical Context for Keratosis

MalaCards organs/tissues related to Keratosis:

39
Skin, Testes, Kidney, T Cells, Liver, Neutrophil, Bone

Publications for Keratosis

Articles related to Keratosis:

(show top 50) (show all 1160)
id Title Authors Year
1
Rare ocular manifestations in keratosis follicularis (Darier-White disease). ( 28905836 )
2017
2
In-clinic application of ingenol mebutate 0.015% gel for actinic keratosis in large areas of the face is feasible and attracts a high rate of patient satisfaction: Results of a questionnaire. ( 28776637 )
2017
3
CD40 Ligand Is Increased in Mast Cells in Psoriasis and Actinic Keratosis but Less So in Epithelial Skin Carcinomas. ( 28267402 )
2017
4
Patient satisfaction and reported outcomes on the management of actinic keratosis. ( 28553130 )
2017
5
Predictors of actinic keratosis count in patients with multiple keratinocyte carcinomas: A cross-sectional study. ( 28088997 )
2017
6
A case report of rare palmoplantar keratosis and nail dystrophy with imatinib. ( 28189257 )
2017
7
Somatic HRAS p.G12S mosaic mutation causes unilaterally distributed epidermal nevi, woolly hair and palmoplantar keratosis. ( 28295558 )
2017
8
Evaluation of the quality of life in patients with arsenic keratosis. ( 28840749 )
2017
9
Epithelial-to-mesenchymal transition contributes to invasion in squamous cell carcinomas originated from actinic keratosis through the differentiated pathway, whereas proliferation plays a more significant role in the classical pathway. ( 28796927 )
2017
10
Acantholytic squamous cell carcinoma is usually associated with hair follicles, not acantholytic actinic keratosis, and is not "high risk": Diagnosis, management, and clinical outcomes in a series of 115 cases. ( 27889291 )
2017
11
Intracapsular tonsillectomy for keratosis pharyngeous: A pilot study of postoperative recovery and surgical efficacy. ( 28931194 )
2017
12
Field treatment of actinic keratosis on the scalp. ( 28581227 )
2017
13
Safety and Efficacy of Escalating Doses of Ingenol Mebutate for Field Treatment of Actinic Keratosis on the Full Face, Full Balding Scalp, or Chest. ( 28628679 )
2017
14
Patient-reported outcomes in topical field treatment of actinic keratosis in Swedish and Danish patients. ( 28658998 )
2017
15
Phasor-FLIM as a Screening Tool for the Differential Diagnosis of Actinic Keratosis, Bowen's Disease, and Basal Cell Carcinoma. ( 28661125 )
2017
16
Human papilloma virus expression in immunocompetent patients with actinic keratosis: A case series. ( 28917462 )
2017
17
A seamless Phase I/II dose-finding trial assessing ingenol disoxate (LEO 43204) for field treatment of actinic keratosis on the scalp. ( 28078678 )
2017
18
Quantitative comparison of the histological subtypes of seborrheic keratosis using computer-aided image analysis. ( 28741724 )
2017
19
In vivo microvascular imaging of cutaneous actinic keratosis, Bowen's disease and squamous cell carcinoma using dynamic optical coherence tomography. ( 28502083 )
2017
20
Keratosis Follicularis Spinulosa Decalvans with Associated Mental Retardation: Response to Isotretinoin. ( 28932071 )
2017
21
Photodynamic Therapy Effective for the Treatment of Actinic Keratosis and Basal Cell Carcinoma in Bullous Pemphigoid Patients. ( 28373119 )
2017
22
Rapidly developed BRAF inhibitor-induced verrucous keratosis. ( 28734005 )
2017
23
Prevalence of actinic keratosis in a French cohort of elderly people: the PROOF study. ( 28906092 )
2017
24
Actinic keratosis modelling in mice: A translational study. ( 28662116 )
2017
25
Rosettes in actinic keratosis and squamous cell carcinoma: distribution, association to other dermoscopic signs and description of the rosette pattern. ( 28707711 )
2017
26
A rare presentation of keratosis follicularis spinulosa decalvans in female twins. ( 28928337 )
2017
27
Keratosis Obturans: A Disease of the Tropics? ( 28929057 )
2017
28
A-101, a Proprietary Topical Formulation of High-Concentration Hydrogen Peroxide Solution: A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Dose-Response Profile in Subjects With Seborrheic Keratosis of the Face. ( 28902028 )
2017
29
Novel nonsense mutation in SERPINB7 and the treatment of foot odor in a patient with Nagashima-type palmoplantar keratosis. ( 28439958 )
2017
30
A Novel Actinic Keratosis Field Assessment Scale for Grading Actinic Keratosis Disease Severity. ( 28536731 )
2017
31
New and current preventive treatment options in actinic keratosis. ( 28805940 )
2017
32
Photodynamic therapy for actinic keratosis: Is the European consensus protocol for daylight PDT superior to conventional protocol for Aktilite CL 128 PDT? ( 28756154 )
2017
33
Assessment of Efficacy and Irritation of Ingenol Mebutate Gel 0.015% Used With or Without Dimethicone Lotion for Treatment of Actinic Keratosis on the Face. ( 28628678 )
2017
34
A review of BF-200 ALA for the photodynamic treatment of mild-to-moderate actinic keratosis. ( 28805092 )
2017
35
Nilotinib-induced Keratosis Pilaris Associated with Alopecia Areata and Eyebrow Thinning. ( 28839396 )
2017
36
Pharmacoeconomic Considerations in Treating Actinic Keratosis: An Update. ( 27785771 )
2017
37
Differential Diagnosis of Seborrheic Keratosis: Clinical and Dermoscopic Features. ( 28915278 )
2017
38
Seborrheic Keratosis With Prominent Clear Cell Changes-A Rare but Important Diagnostic Variant. ( 28937426 )
2017
39
Dermatoscopic Patterns of Nonfacial Actinic Keratosis: Characterization of Pigmented and Nonpigmented Lesions. ( 28538027 )
2017
40
Nagashima-type palmoplantar keratosis with melanoma: absence of epidermal Langerhans cells in hyperkeratotic skin. ( 28251895 )
2017
41
Actinic keratosis. Or maybe not? ( 28556349 )
2017
42
Photodynamic therapy is more effective than imiquimod for actinic keratosis in organ transplant recipients - a randomized intra-individual controlled trial. ( 28796885 )
2017
43
Dermoscopy of Pigmented Actinic Keratosis of the Face: A Study of 232 Cases. ( 28705516 )
2017
44
Response to: a network meta-analysis of the relative efficacy of treatments for actinic keratosis of the face or scalp in Europe. ( 27503743 )
2016
45
Nagashima-type palmoplantar keratosis in a Chinese Han population. ( 27666198 )
2016
46
Adherence to topical therapies in actinic keratosis: A literature review. ( 27161045 )
2016
47
Expression of p300 and p300/CBP associated factor (PCAF) in actinic keratosis and squamous cell carcinoma of the skin. ( 27019369 )
2016
48
Novel frame-shift mutation in SERPINB7 in a Japanese patient with Nagashima-type palmoplantar keratosis. ( 27569382 )
2016
49
Adherence to topical treatments for actinic keratosis. ( 27790670 )
2016
50
Progressive Nagashima-type palmoplantar keratosis in a Chinese patient with recurrent c.796C>T mutation in SERPINB7. ( 27506501 )
2016

Variations for Keratosis

Expression for Keratosis

Search GEO for disease gene expression data for Keratosis.

Pathways for Keratosis

Pathways related to Keratosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 FGFR3 FLG IVL KRT1 KRT10 KRT17
2
Show member pathways
11.56 FLG IVL KRT1 KRT10 KRT17 KRT9
3 11.36 CDKN2A FGFR3 TP53
4 11.3 CDKN2A PIK3CA TP53
5 10.94 FGFR3 PIK3CA TP53

GO Terms for Keratosis

Cellular components related to Keratosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.35 FLG KRT1 KRT10 KRT17 KRT9
2 cornified envelope GO:0001533 8.92 FLG IVL KRT1 KRT10
3 cytosol GO:0005829 10 CDKN2A FLG GJB2 IVL KRT1 KRT10

Biological processes related to Keratosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.65 IVL KRT1 KRT10 KRT17 KRT9
2 epidermis development GO:0008544 9.63 ATP2A2 KRT17 KRT9
3 keratinocyte differentiation GO:0030216 9.5 FLG IVL KRT10
4 peptide cross-linking GO:0018149 9.46 FLG IVL KRT1 KRT10
5 intermediate filament organization GO:0045109 9.43 KRT17 KRT9
6 replicative senescence GO:0090399 9.4 CDKN2A TP53
7 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress GO:1990440 9.37 MBTPS2 TP53
8 skin epidermis development GO:0098773 9.13 FLG KRT1 KRT10
9 cornification GO:0070268 9.1 FLG IVL KRT1 KRT10 KRT17 KRT9

Molecular functions related to Keratosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.26 FLG IVL KRT1 KRT17
2 structural constituent of epidermis GO:0030280 8.8 FLG KRT1 KRT10

Sources for Keratosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....