MCID: KRT009
MIFTS: 50

Keratosis malady

Skin diseases category
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Summaries for Keratosis

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Wikipedia:65 Keratosis (from keratinocyte, the prominent cell type in the epidermis, and -osis, abnormal) is a growth... more...

MalaCards based summary: Keratosis, also known as hyperkeratosis, is related to actinic keratosis and keratosis follicularis spinulosa decalvans. An important gene associated with Keratosis is SAT1 (spermidine/spermine N1-acetyltransferase 1), and among its related pathways are Staphylococcus aureus infection and Antiarrhythmic Pathway, Pharmacodynamics. The compounds tazarotene and isotretinoin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and colon, and related mouse phenotypes are reproductive system and tumorigenesis.

Aliases & Classifications for Keratosis

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Keratosis, Aliases & Descriptions:

Name: Keratosis 8 10
 
Hyperkeratosis 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:161
NCIt39 C34747
SNOMED-CT57 254666005
MeSH34 D007642

Related Diseases for Keratosis

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Diseases related to Keratosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 194)
idRelated DiseaseScoreTop Affiliating Genes
1actinic keratosis32.4TP63
2keratosis follicularis spinulosa decalvans31.8SAT1
3seborrheic keratosis31.6PIK3CA, FGFR3
4keratosis follicularis31.5SAT1, ATP2A2, MBTPS2
5palmoplantar keratosis31.3DSG1, CTSC
6lichen planus31.0KRT10, KRT1
7leukoplakia30.9KRT1
8mongolian spot30.7DSP, ATP2A2
9keratoderma30.6DSP, DSG1, KRT1
10epidermolytic hyperkeratosis30.4KRT10, KRT1
11pemphigus30.3DSG1, DSP
12hailey-hailey disease30.2ATP2A2, DSP
13congenital ichthyosiform erythroderma30.2KRT10, KRT1
14melanoma30.1TP63, DSG1, SAT1, FGFR3, PIK3CA
15papilloma30.0FGFR3, KRT10, TP63
16bullous pemphigoid29.9DSG1, DSP
17nonepidermolytic palmoplantar keratoderma29.8CTSC, KRT1, DSG1, KRT10
18retinoblastoma29.5PIK3CA, KRT10, FGFR3
19adenocarcinoma29.5KRT10, TP63, PIK3CA, CTSC, KRT1
20leukemia28.9KRT10, FGFR3, PIK3CA, SAT1
21breast cancer28.8TP63, DSP, SAT1, PIK3CA, FGFR3
22basal cell carcinoma10.7
23inverted follicular keratosis10.6
24epidermolytic acanthoma10.5KRT1
25blindness10.4
26leopard syndrome10.4DSP
27ichthyosis, cyclic, with epidermolytic hyperkeratosis10.3KRT10, KRT1
28vulvar seborrheic keratosis10.3
29alopecia10.3
30acanthoma10.3
31alopecia congenita keratosis palmoplantaris10.3
32bowen syndrome10.3KRT10, KRT1
33epidermolysis bullosa simplex10.3KRT10, KRT1
34epidermodysplasia verruciformis10.2
35inflamed seborrheic keratosis10.2
36keratoacanthoma10.2
37keratosis follicularis dwarfism and cerebral atrophy10.2
38keratosis palmoplantaris striata i, ad10.2
39oral leukoplakia10.2KRT1, TP63
40psoriasis10.2
41keratosis focal palmoplantar gingival10.2
42keratosis palmoplantaris striata 310.2
43tylosis with esophageal cancer10.2
44keratosis follicularis spinulosa decalvans, x-linked10.2
45astigmatism10.2FGFR3, CTSC
46cervical squamous cell carcinoma10.2KRT10, TP63
47pemphigus vulgaris10.2DSP, DSG1
48burnett schwartz berberian syndrome10.2
49erythrokeratodermia variabilis et progressiva10.2
50keratosis palmoplantaris papulosa10.2

Graphical network of the top 20 diseases related to Keratosis:



Diseases related to keratosis

Symptoms for Keratosis

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Drugs & Therapeutics for Keratosis

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Drug clinical trials:

Search ClinicalTrials for Keratosis

Search NIH Clinical Center for Keratosis

Genetic Tests for Keratosis

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Anatomical Context for Keratosis

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MalaCards organs/tissues related to Keratosis:

32
Skin, Breast, Colon, Liver, Testes, T cells, Kidney, Myeloid

Animal Models for Keratosis or affiliated genes

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MGI Mouse Phenotypes related to Keratosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.9SAT1, TP63, ATP2A2, PIK3CA, FGFR3
2MP:00020067.6PIK3CA, FGFR3, KRT10, SAT1, TP63, ATP2A2
3MP:00053877.1ATP2A2, FGFR3, CTSC, KRT1, KRT10, TP63
4MP:00053767.0ATP2A2, CTSC, KRT1, PIK3CA, FGFR3, SAT1
5MP:00053847.0SAT1, PIK3CA, FGFR3, ATP2A2, TP63, DSP
6MP:00107716.7KRT1, FGFR3, CTSC, KRT10, PIK3CA, ATP2A2
7MP:00107686.6DSP, KRT10, TP63, PIK3CA, ATP2A2, FGFR3
8MP:00053786.4TP63, DSP, SAT1, FGFR3, CTSC, ATP2A2

Publications for Keratosis

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Articles related to Keratosis:

(show top 50)    (show all 935)
idTitleAuthorsYear
1
Efficacy of imiquimod 3.75% from Lmax according to the number of actinic keratosis lesions. (25351284)
2014
2
Treatment of Keratosis Pilaris With 810-nm Diode Laser: Randomized Clinical Trial. (25372313)
2014
3
Highly prevalent SERPINB7 founder mutation causes pseudodominant inheritance pattern in Nagashima-type palmoplantar keratosis. (24773080)
2014
4
Epithelial Stem Cells of the Skin Contribute to the Histopathologic Umbrella-like Appearance in Actinic Keratosis. (25349467)
2014
5
Inhibition of keratinocyte proliferation by phospholipid-conjugates of a TLR7 ligand in a Myc-induced hyperplastic actinic keratosis model in the absence of systemic side effects. (24225049)
2013
6
Current issues in the management of actinic keratosis. (23228304)
2013
7
Actinic keratosis underlying cutaneous horn at an unusual site-a case report. (24294287)
2013
8
Photodynamic therapy for actinic keratosis in organ transplant patients. (22151793)
2013
9
Photopneumatic therapy for the treatment of keratosis pilaris. (23884495)
2013
10
Microarray analysis reveals increased expression of I9Np63I+ in seborrhoeic keratosis. (21967648)
2012
11
Ingenol mebutate gel for actinic keratosis. (22417254)
2012
12
Topical 5-fluorouracil for the treatment of periocular actinic keratosis and low-grade squamous malignancy. (22460673)
2012
13
Discrimination of squamous cell carcinoma in situ from seborrheic keratosis by color analysis techniques requires information from scale, scale-crust and surrounding areas in dermoscopy images. (23117020)
2012
14
Keratosis pilaris revisited: is it more than just a follicular keratosis? (23766609)
2012
15
A randomized pilot comparative study of topical methyl aminolevulinate photodynamic therapy versus imiquimod 5% versus sequential application of both therapies in immunocompetent patients with actinic keratosis: clinical and histologic outcomes. (22226430)
2012
16
Keratosis pilaris rubra and keratosis pilaris atrophicans faciei treated with pulsed dye laser: report of 10 cases. (20569297)
2011
17
Eyebrow reconstruction in dormant keratosis pilaris atrophicans. (21723799)
2011
18
Coexistent Dowling-Degos disease and reticulate acropigmentation of kitamura with progressive seborrheic keratosis. (21416772)
2011
19
Sebaceous carcinoma associated with seborrheic keratosis. (20868621)
2010
20
The keratin-14 expression in actinic keratosis and squamous cell carcinoma: is this a prognostic factor for tumor progression? (20622965)
2010
21
Actinic keratosis: facts and controversies. (20541675)
2010
22
Review ofactinic keratosis. Part I: etiology, epidemiology and clinical presentation. (20865846)
2010
23
Effectiveness of cross polarized light and fluorescence diagnosis for detection of sub-clinical and clinical actinic keratosis during imiquimod treatment. (20201959)
2010
24
Erosive pustular dermatosis of the scalp following treatment with topical imiquimod for actinic keratosis. (19917978)
2009
25
'Nagashima-type' keratosis palmoplantaris in two siblings. (19470072)
2009
26
Keratosis follicularis spinulosa decalvans in a family. (18280351)
2008
27
A dermatoscopically diagnosed collision tumour: malignant melanoma arising within a seborrhoeic keratosis. (18462448)
2008
28
Melanoma in-situ arising in seborrheic keratosis: a case report. (18947402)
2008
29
Variable pulsed light is less painful than light-emitting diodes for topical photodynamic therapy of actinic keratosis: a prospective randomized controlled trial. (17542980)
2007
30
The Delphi panel in the economic evaluation of photodynamic therapy for actinic keratosis and basal cell carcinoma: poor results? (17535242)
2007
31
Management of actinic keratosis patients: a qualitative study. (17365267)
2007
32
The diagnostic concordance of actinic keratosis and squamous cell carcinoma. (16965343)
2006
33
A case of follicular keratosis with trichostasis on an amputated limb. (16716178)
2006
34
Clinical diagnosis of actinic keratosis identifies an elderly population at high risk of developing skin cancer. (15720095)
2005
35
Pityrosporum and seborrheic keratosis: an association. (16150211)
2005
36
Diseases of the epidermis: pityriasis rosea, lichen planus, keratosis pilaris. (16463931)
2005
37
Inverted follicular keratosis simulating malignant melanoma. (14961911)
2004
38
From actinic keratosis to squamous cell carcinoma. (11966728)
2002
39
Gene dosage of the spermidine/spermine N(1)-acetyltransferase (SSAT) gene with putrescine accumulation in a patient with a Xp21.1p22.12 duplication and keratosis follicularis spinulosa decalvans (KFSD). (12215835)
2002
40
Comparative histochemical study of Bowen's disease and actinic keratosis: preserved normal basal cells in Bowen's disease. (11512639)
2001
41
Multiple actinic keratosis and skin tumors secondary to hydroxyurea treatment. (9568428)
1998
42
Molecular genetic analysis of two families with keratosis follicularis spinulosa decalvans: refinement of gene localization and evidence for genetic heterogeneity. (9341865)
1997
43
Malignancy arising in seborrheic keratosis: a report of two cases. (9208082)
1997
44
Identification of the genetic locus for keratosis palmaris et plantaris on chromosome 17 near the RARA and keratin type I genes. (7504553)
1993
45
Actinic keratosis: preventable and treatable like other precancerous and cancerous skin lesions. (2675146)
1989
46
POEMS syndrome associated with cryoglobulinemia, lymphoma, multiple seborrheic keratosis, and ichthyosis. (2848065)
1988
47
Malignant melanoma appearing in seborrheic keratosis. (6232304)
1984
48
Inverted follicular keratosis is a distinct follicular tumor. (6660428)
1983
49
Actinic keratosis and telangiectasia. (5060883)
1972
50
Actinic Keratosis of the Left Forearm Due to Driving an Automobile. (18745405)
1939

Variations for Keratosis

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Expression for genes affiliated with Keratosis

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Expression patterns in normal tissues for genes affiliated with Keratosis

Search GEO for disease gene expression data for Keratosis.

Pathways for genes affiliated with Keratosis

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Pathways related to Keratosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6KRT10, DSG1
29.6ATP2A2, DSP
39.5DSP, KRT1
4
Show member pathways
9.5DSG1, DSP
5
Show member pathways
9.1DSP, PIK3CA
6
Show member pathways
9.0FGFR3, PIK3CA
7
Show member pathways
9.0FGFR3, PIK3CA
8
Show member pathways
9.0FGFR3, PIK3CA
98.5FGFR3, TP63, PIK3CA

Compounds for genes affiliated with Keratosis

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Compounds related to Keratosis according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1tazarotene44 1110.9KRT1, KRT10
2isotretinoin44 1110.9KRT10, KRT1
3ryanodine44 28 6111.6DSP, ATP2A2
4isoleucine449.6KRT10, KRT1
5hematoxylin449.5TP63, KRT10, KRT1
6iodide44 2410.4KRT10, PIK3CA
7histidine449.3TP63, KRT10, CTSC
8proline449.1CTSC, KRT10, KRT1
9lysine448.9FGFR3, KRT1, SAT1, TP63
10paraffin448.8KRT10, TP63, KRT1, FGFR3
11dmso448.8DSP, TP63, PIK3CA
12bromodeoxyuridine448.7TP63, KRT10, KRT1, PIK3CA
13doxorubicin44 50 1110.5PIK3CA, FGFR3, TP63
14threonine448.4KRT10, PIK3CA, KRT1, FGFR3
15estrogen448.3SAT1, TP63, PIK3CA, KRT10, KRT1
16progesterone44 28 61 24 1112.1PIK3CA, TP63, KRT10, KRT1, DSP
17steroid448.1DSP, KRT1, KRT10, PIK3CA, TP63
18glutamate448.0FGFR3, PIK3CA, KRT1, KRT10, TP63
19retinoic acid44 248.7PIK3CA, KRT10, KRT1, DSG1, DSP, TP63
20tyrosine447.5TP63, PIK3CA, KRT1, DSP, KRT10, FGFR3
21arginine447.5FGFR3, KRT1, KRT10, SAT1, TP63, PIK3CA
22calcium44 50 24 119.7ATP2A2, PIK3CA, KRT1, KRT10, DSG1, DSP
23serine446.7FGFR3, DSP, SAT1, PIK3CA, ATP2A2, DSG1

GO Terms for genes affiliated with Keratosis

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Cellular components related to Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic side of plasma membraneGO:0098989.4FGFR3, DSG1
2desmosomeGO:0300579.2DSG1, DSP

Biological processes related to Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular component disassembly involved in execution phase of apoptosisGO:0069219.5DSG1, DSP
2positive regulation of apoptotic signaling pathwayGO:20012359.3CTSC, TP63
3keratinocyte differentiationGO:0302169.0KRT10, DSP, TP63

Molecular functions related to Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.6FGFR3, CTSC, KRT1, SAT1, DSP, TP63

Products for genes affiliated with Keratosis

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  • Antibodies
  • Proteins
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Sources for Keratosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet