MCID: KRT009
MIFTS: 49

Keratosis malady

Skin diseases category

Summaries for Keratosis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Keratosis (from keratinocyte, the prominent cell type in the epidermis and -osis, abnormal) is a growth... more...

MalaCards: Keratosis, also known as hyperkeratosis, is related to actinic keratosis and seborrheic keratosis. An important gene associated with Keratosis is SAT1 (spermidine/spermine N1-acetyltransferase 1), and among its related pathways are Staphylococcus aureus infection and Antiarrhythmic Pathway, Pharmacodynamics. The compounds tazarotene and isotretinoin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and colon, and related mouse phenotypes are reproductive system and tumorigenesis.

Aliases & Classifications for Keratosis

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

keratosis 9 11
hyperkeratosis 63


External Ids:

Disease Ontology9 DOID:161
NCIt41 C34747
SNOMED-CT59 254666005
MeSH36 D007642

Related Diseases for Keratosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Keratosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1actinic keratosis31.9TP63
2seborrheic keratosis31.5PIK3CA, FGFR3
3keratosis follicularis31.1ATP2A2, SAT1, MBTPS2
4keratosis follicularis spinulosa decalvans31.1SAT1
5palmoplantar keratosis30.8CTSC, DSG1
6melanoma30.7PIK3CA, TP63, DSG1, SAT1, FGFR3
7lichen planus30.7KRT1, KRT10
8keratoderma30.5KRT1, DSG1, DSP
9mongolian spot30.4DSP, ATP2A2
10leukoplakia30.4KRT1
11epidermolytic hyperkeratosis30.1KRT1, KRT10
12pemphigus30.1DSP, DSG1
13papilloma30.0TP63, KRT10, FGFR3
14adenocarcinoma30.0PIK3CA, TP63, KRT10, KRT1, CTSC
15retinoblastoma29.9FGFR3, KRT10, PIK3CA
16hailey-hailey disease29.9DSP, ATP2A2
17congenital ichthyosiform erythroderma29.9KRT10, KRT1
18bullous pemphigoid29.8DSG1, DSP
19breast cancer29.5PIK3CA, TP63, DSP, SAT1, FGFR3
20basal cell carcinoma10.7
21inverted follicular keratosis10.6
22keratosis pilaris atrophicans10.5
23blindness10.3
24acanthoma10.3
25alopecia10.3
26alopecia congenita keratosis palmoplantaris10.3
27inflamed seborrheic keratosis10.2
28epidermodysplasia verruciformis10.2
29keratoacanthoma10.2
30keratosis follicularis dwarfism and cerebral atrophy10.2
31keratosis palmoplantaris striata i, ad10.2
32keratosis follicularis spinulosa decalvans, x-linked10.2
33psoriasis10.2
34vulvar seborrheic keratosis10.2
35keratosis palmoplantaris striata 310.2
36keratosis linearis with ichthyosis congenita and sclerosing keratoderma10.2
37keratosis focal palmoplantar gingival10.1
38keratosis palmoplantaris papulosa10.1
39keratosis palmoplantaris striata 110.1
40ulerythema ophryogenesis10.1
41epidermolytic acanthoma10.1KRT1
42leopard syndrome10.1DSP
43superficial basal cell carcinoma10.1
44folliculitis10.1
45acne10.1
46cholesteatoma10.1
47dermatitis10.1
48hypotrichosis10.1
49laryngitis10.1
50lupus erythematosus10.1

Graphical network of the top 20 diseases related to Keratosis:



Diseases related to keratosis

Symptoms for Keratosis

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Drugs & Therapeutics for Keratosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Keratosis

Drug clinical trials:

Search ClinicalTrials for Keratosis

Search NIH Clinical Center for Keratosis

Search CenterWatch for Keratosis

Genetic Tests for Keratosis

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Anatomical Context for Keratosis

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34MalaCards
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MalaCards organs/tissues related to Keratosis:

34
Skin, Breast, Colon, Liver, Testes, T cells, Kidney, Myeloid

Animal Models for Keratosis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Keratosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.9FGFR3, SAT1, TP63, ATP2A2, PIK3CA
2MP:00020067.6PIK3CA, ATP2A2, TP63, SAT1, KRT10, FGFR3
3MP:00053877.1PIK3CA, ATP2A2, TP63, KRT10, KRT1, CTSC
4MP:00053767.0PIK3CA, ATP2A2, TP63, SAT1, KRT1, CTSC
5MP:00053847.0PIK3CA, ATP2A2, TP63, DSP, SAT1, CTSC
6MP:00107716.7FGFR3, PIK3CA, ATP2A2, TP63, DSP, KRT10
7MP:00107686.6PIK3CA, ATP2A2, TP63, DSP, KRT10, KRT1
8MP:00053786.4PIK3CA, ATP2A2, TP63, DSP, SAT1, KRT10

Publications for Keratosis

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Sources:
53PubMed
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Articles related to Keratosis:

(show top 50)    (show all 898)
idTitleAuthorsYear
1
Inhibition of keratinocyte proliferation by phospholipid-conjugates of a TLR7 ligand in a Myc-induced hyperplastic actinic keratosis model in the absence of systemic side effects. (24225049)
2013
2
Current issues in the management of actinic keratosis. (23228304)
2013
3
Actinic keratosis underlying cutaneous horn at an unusual site-a case report. (24294287)
2013
4
Photopneumatic therapy for the treatment of keratosis pilaris. (23884495)
2013
5
Microarray analysis reveals increased expression of I9Np63I+ in seborrhoeic keratosis. (21967648)
2012
6
Ingenol mebutate gel for actinic keratosis. (22417254)
2012
7
Topical 5-fluorouracil for the treatment of periocular actinic keratosis and low-grade squamous malignancy. (22460673)
2012
8
Longitudinal erythronychia with subungual keratosis: a daughter subungual nail. (22681540)
2012
9
Discrimination of squamous cell carcinoma in situ from seborrheic keratosis by color analysis techniques requires information from scale, scale-crust and surrounding areas in dermoscopy images. (23117020)
2012
10
Keratosis pilaris revisited: is it more than just a follicular keratosis? (23766609)
2012
11
A randomized pilot comparative study of topical methyl aminolevulinate photodynamic therapy versus imiquimod 5% versus sequential application of both therapies in immunocompetent patients with actinic keratosis: clinical and histologic outcomes. (22226430)
2012
12
Keratosis pilaris rubra and keratosis pilaris atrophicans faciei treated with pulsed dye laser: report of 10 cases. (20569297)
2011
13
Eyebrow reconstruction in dormant keratosis pilaris atrophicans. (21723799)
2011
14
Coexistent Dowling-Degos disease and reticulate acropigmentation of kitamura with progressive seborrheic keratosis. (21416772)
2011
15
Sebaceous carcinoma associated with seborrheic keratosis. (20868621)
2010
16
The keratin-14 expression in actinic keratosis and squamous cell carcinoma: is this a prognostic factor for tumor progression? (20622965)
2010
17
Actinic keratosis: facts and controversies. (20541675)
2010
18
Review ofactinic keratosis. Part I: etiology, epidemiology and clinical presentation. (20865846)
2010
19
Effectiveness of cross polarized light and fluorescence diagnosis for detection of sub-clinical and clinical actinic keratosis during imiquimod treatment. (20201959)
2010
20
Erosive pustular dermatosis of the scalp following treatment with topical imiquimod for actinic keratosis. (19917978)
2009
21
'Nagashima-type' keratosis palmoplantaris in two siblings. (19470072)
2009
22
Keratosis follicularis spinulosa decalvans in a family. (18280351)
2008
23
A dermatoscopically diagnosed collision tumour: malignant melanoma arising within a seborrhoeic keratosis. (18462448)
2008
24
Melanoma in-situ arising in seborrheic keratosis: a case report. (18947402)
2008
25
Variable pulsed light is less painful than light-emitting diodes for topical photodynamic therapy of actinic keratosis: a prospective randomized controlled trial. (17542980)
2007
26
The Delphi panel in the economic evaluation of photodynamic therapy for actinic keratosis and basal cell carcinoma: poor results? (17535242)
2007
27
Management of actinic keratosis patients: a qualitative study. (17365267)
2007
28
The diagnostic concordance of actinic keratosis and squamous cell carcinoma. (16965343)
2006
29
A case of follicular keratosis with trichostasis on an amputated limb. (16716178)
2006
30
Clinical diagnosis of actinic keratosis identifies an elderly population at high risk of developing skin cancer. (15720095)
2005
31
Pityrosporum and seborrheic keratosis: an association. (16150211)
2005
32
Efficacy of 3 different light doses in the treatment of actinic keratosis with 5-aminolevulinic acid photodynamic therapy: a randomized, observer-blinded, intrapatient, comparison study. (16243131)
2005
33
Inverted follicular keratosis simulating malignant melanoma. (14961911)
2004
34
From actinic keratosis to squamous cell carcinoma. (11966728)
2002
35
Gene dosage of the spermidine/spermine N(1)-acetyltransferase (SSAT) gene with putrescine accumulation in a patient with a Xp21.1p22.12 duplication and keratosis follicularis spinulosa decalvans (KFSD). (12215835)
2002
36
Comparative histochemical study of Bowen's disease and actinic keratosis: preserved normal basal cells in Bowen's disease. (11512639)
2001
37
Multiple actinic keratosis and skin tumors secondary to hydroxyurea treatment. (9568428)
1998
38
Molecular genetic analysis of two families with keratosis follicularis spinulosa decalvans: refinement of gene localization and evidence for genetic heterogeneity. (9341865)
1997
39
Malignancy arising in seborrheic keratosis: a report of two cases. (9208082)
1997
40
Identification of the genetic locus for keratosis palmaris et plantaris on chromosome 17 near the RARA and keratin type I genes. (7504553)
1993
41
Actinic keratosis: preventable and treatable like other precancerous and cancerous skin lesions. (2675146)
1989
42
POEMS syndrome associated with cryoglobulinemia, lymphoma, multiple seborrheic keratosis, and ichthyosis. (2848065)
1988
43
Seborrheic keratosis? (3965523)
1985
44
Malignant melanoma appearing in seborrheic keratosis. (6232304)
1984
45
Inverted follicular keratosis is a distinct follicular tumor. (6660428)
1983
46
Evaluation of 5-fluorouracil in the treatment of actinic keratosis of the lip. (6946379)
1981
47
A tridimensional view of seborrheic keratosis. (6447911)
1980
48
Actinic keratosis and telangiectasia. (5060883)
1972
49
Treatment of seborrheic keratosis. (4247377)
1970
50
Actinic Keratosis of the Left Forearm Due to Driving an Automobile. (18745405)
1939

Variations for Keratosis

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Expression for genes affiliated with Keratosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratosis

Search GEO for disease gene expression data for Keratosis.

Pathways for genes affiliated with Keratosis

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Sources:
51PathCards, 31KEGG, 52PharmGKB, 61Thomson Reuters, 56Reactome, 39NCBI BioSystems Database, 62Tocris Bioscience
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Pathways related to Keratosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6KRT10, DSG1
29.6ATP2A2, DSP
39.5DSP, KRT1
4
Show member pathways
9.5DSG1, DSP
5
Show member pathways
9.1DSP, PIK3CA
6
Show member pathways
9.0FGFR3, PIK3CA
7
Show member pathways
9.0FGFR3, PIK3CA
8
Show member pathways
9.0FGFR3, PIK3CA
98.5FGFR3, TP63, PIK3CA

Compounds for genes affiliated with Keratosis

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 52PharmGKB
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Compounds related to Keratosis according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1tazarotene46 1210.9KRT1, KRT10
2isotretinoin46 1210.9KRT1, KRT10
3ryanodine46 30 6211.6DSP, ATP2A2
4isoleucine469.6KRT10, KRT1
5hematoxylin469.5KRT1, KRT10, TP63
6iodide46 2510.4KRT10, PIK3CA
7histidine469.3TP63, KRT10, CTSC
8proline469.1CTSC, KRT1, KRT10
9lysine468.9FGFR3, KRT1, SAT1, TP63
10paraffin468.8FGFR3, KRT1, KRT10, TP63
11dmso468.8PIK3CA, TP63, DSP
12bromodeoxyuridine468.7PIK3CA, TP63, KRT10, KRT1
13doxorubicin46 52 1210.5FGFR3, TP63, PIK3CA
14threonine468.4PIK3CA, KRT10, KRT1, FGFR3
15estrogen468.3PIK3CA, TP63, SAT1, KRT10, KRT1
16progesterone46 30 62 25 1212.1PIK3CA, TP63, DSP, KRT10, KRT1
17steroid468.1PIK3CA, TP63, DSP, KRT10, KRT1
18glutamate468.0PIK3CA, TP63, KRT10, KRT1, FGFR3
19retinoic acid46 258.7PIK3CA, TP63, DSP, DSG1, KRT10, KRT1
20tyrosine467.5PIK3CA, TP63, DSP, KRT10, KRT1, FGFR3
21arginine467.5PIK3CA, TP63, SAT1, KRT10, KRT1, CTSC
22calcium46 52 25 129.7PIK3CA, ATP2A2, TP63, DSP, DSG1, KRT10
23serine466.7FGFR3, PIK3CA, ATP2A2, DSP, DSG1, SAT1

GO Terms for genes affiliated with Keratosis

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17Gene Ontology
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Cellular components related to Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic side of plasma membraneGO:0098989.4FGFR3, DSG1
2desmosomeGO:0300579.2DSG1, DSP

Biological processes related to Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular component disassembly involved in execution phase of apoptosisGO:0069219.5DSG1, DSP
2positive regulation of apoptotic signaling pathwayGO:20012359.3CTSC, TP63
3keratinocyte differentiationGO:0302169.0KRT10, DSP, TP63

Molecular functions related to Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.6FGFR3, CTSC, KRT1, SAT1, DSP, TP63

Products for genes affiliated with Keratosis

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Sources for Keratosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet