MCID: KRT009
MIFTS: 49

Keratosis malady

Summaries for Keratosis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Keratosis (from: keratinocyte, the prominent cell type in the epidermis and -osis, abnormal) a growth of... more...

MalaCards: Keratosis, also known as hyperkeratosis, is related to actinic keratosis and squamous cell carcinoma. An important gene associated with Keratosis is SAT1 (spermidine/spermine N1-acetyltransferase 1), and among its related pathways are MicroRNAs in cancer and Pathways in cancer. The compounds serine and retinoic acid have been mentioned in the context of this disorder. Related mouse phenotypes are growth/size and immune system.

Aliases & Classifications for Keratosis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt, 35MeSH, 57SNOMED-CT
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Aliases & Descriptions:

keratosis 8 10
hyperkeratosis 61


External Ids:

Disease Ontology8 DOID:161
NCIt40 C34747
SNOMED-CT57 254666005
MeSH35 D007642

Related Diseases for Keratosis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Keratosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 419)
idRelated DiseaseScoreTop Affiliating Genes
1actinic keratosis31.7TP63, CYP27B1, PCNA, GHR
2squamous cell carcinoma31.2PIK3CA, ATP2A2, GHR, DSP, DSG1, PCNA
3keratosis follicularis31.0ATP2A2, MBTPS2, SAT1
4basal cell carcinoma31.0TP63, BCL2, KRT10, CYP27B1
5keratosis follicularis spinulosa decalvans30.9KFSD, SAT1
6lichen planus30.6KRT10, KRT1
7keratoderma30.4DSP, DSG1, KRT1
8alopecia30.3MBTPS2
9mongolian spot30.3DSP, ATP2A2
10epidermolysis bullosa simplex30.3KRT10, KRT1
11leukoplakia30.2PCNA, KRT1
12adenocarcinoma30.1CTSC, PIK3CA, GHR, PCNA, CYP27B1, KRT1
13nonepidermolytic palmoplantar keratoderma30.0CTSC, DSG1, KRT1, KRT10
14ichthyosis, cyclic, with epidermolytic hyperkeratosis30.0KRT1, KRT10
15oral leukoplakia29.9PCNA, KRT1, TP63
16epidermolytic hyperkeratosis29.9KRT1, KRT10
17oral cancer29.9PCNA
18hailey-hailey disease29.7DSP, ATP2A2
19amyloidosis29.7KRT10
20hyperkeratosis lenticularis perstans10.6
21keratosis pilaris atrophicans10.5
22skin squamous cell carcinoma10.4
23acanthoma10.2
24alopecia congenita keratosis palmoplantaris10.2
25keratosis follicularis spinulosa decalvans, x-linked10.2
26inflamed seborrheic keratosis10.2
27epidermodysplasia verruciformis10.2
28vulvar seborrheic keratosis10.2
29keratosis follicularis dwarfism and cerebral atrophy10.2
30keratosis palmoplantaris striata i, ad10.2
31hyperkeratosis-hyperpigmentation syndrome10.2
32keratosis focal palmoplantar gingival10.2
33keratosis palmoplantaris striata 310.2
34keratoderma palmoplantar deafness10.2
35acquired hyperkeratosis10.1
36anal squamous cell carcinoma10.1
37keratosis palmoplantaris papulosa10.1
38keratosis palmoplantaris striata 110.1
39ulerythema ophryogenesis10.1
40keratosis linearis with ichthyosis congenita and sclerosing keratoderma10.1
41bart-pumphrey syndrome10.1
42palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal10.1
43paraplegia - intellectual deficit - hyperkeratosis10.1
44arthrogryposis - hyperkeratosis, lethal form10.1
45superficial basal cell carcinoma10.1
46folliculitis10.1
47vulvar inverted follicular keratosis10.1
48n syndrome10.1
49acne10.1
50burnett schwartz berberian syndrome10.1

Graphical network of the top 20 diseases related to Keratosis:



Diseases related to keratosis

Clinical Features for Keratosis

Drugs & Therapeutics for Keratosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Keratosis

Drug clinical trials:

Search ClinicalTrials for Keratosis

Search NIH Clinical Center for Keratosis

Search CenterWatch for Keratosis

Genetic Tests for Keratosis

Anatomical Context for Keratosis

Animal Models for Keratosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Keratosis

Sources:
51PubMed
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Articles related to Keratosis:

(show top 50)    (show all 908)
idTitleAuthorsYear
1
Combination peel with incorporated fractional prickle coral calcium for the treatment of keratosis pilaris: a pilot study. (22385102)
2014
2
Paracrine cytokine mechanisms underlying the hyperpigmentation of seborrheic keratosis in covered skin areas. (23662587)
2013
3
Basal cell carcinoma, oculo-cutaneous albinism and actinic keratosis in a native Indian. (24082183)
2013
4
Expression of Lumican in Hidroacanthoma Simplex and Clonal-Type Seborrheic Keratosis as a Potent Differential Diagnostic Marker. (23656908)
2013
5
Understanding efficacy end-points in studies of field-directed therapy for actinic keratosis. (23962263)
2013
6
Mutations in SERPINB7, encoding a member of the serine protease inhibitor superfamily, cause Nagashima-type palmoplantar keratosis. (24207119)
2013
7
No Evidence of Human Papillomaviruses in Non-genital Seborrheic Keratosis. (23919020)
2013
8
The expression of p53 and COX-2 in basal cell carcinoma, squamous cell carcinoma and actinic keratosis cases. (22627629)
2012
9
Intraepidermal sebaceous carcinoma occurring concurrently with actinic keratosis. (22416794)
2012
10
Seborrheic keratosis of the external auditory canal. (22710550)
2012
11
Coexistent Dowling-Degos disease and reticulate acropigmentation of kitamura with progressive seborrheic keratosis. (21416772)
2011
12
Extensive verrucous seborrheic keratosis mimicking deep mycoses. (23130245)
2011
13
Juvenile-onset keratosis lichenoides chronica treated successfully with topical tacrolimus: a safe and favourable outcome. (21659068)
2011
14
Comparison of topical 5-fluorouracil formulations in actinic keratosis treatment. (19878034)
2010
15
Spreading pigmented actinic keratosis: a review. (20334953)
2010
16
Easy to diagnose, difficult to treat: keratosis lichenoides chronica. (19196302)
2010
17
Myiasis in a large perigenital seborrheic keratosis. (21063538)
2010
18
Erosive pustular dermatosis of the scalp following treatment with topical imiquimod for actinic keratosis. (19917978)
2009
19
Sunlight (actinic) keratosis: an update. (20812516)
2009
20
Keratosis follicularis spinulosa decalvans in a family. (18280351)
2008
21
Keratosis lichenoides chronica treated with acitretin plus narrowband ultraviolet B phototherapy. (18346262)
2008
22
Real-life practice study of the clinical outcome and cost-effectiveness of photodynamic therapy using methyl aminolevulinate (MAL-PDT) in the management of actinic keratosis and basal cell carcinoma. (18693157)
2008
23
Vulvar seborrheic keratosis. (18053380)
2007
24
Analysis of SDHD and MMP12 in an affected solar keratosis and control cohort. (17727250)
2007
25
Seborrheic keratosis of the nasal vestibule. (18187992)
2007
26
Mechanisms of action of new treatment modalities for actinic keratosis. (16485885)
2006
27
Dermoscopy of lichenoid regressing seborrheic keratosis. (16549732)
2006
28
Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice. (15128703)
2004
29
The immunopathology of regression in benign lichenoid keratosis, keratoacanthoma and halo nevus. (15931341)
2004
30
Seborrheic keratosis in the Korean males: causative role of sunlight. (12945806)
2003
31
S100A protein expression in the distinction between lentigo maligna and pigmented actinic keratosis. (12652189)
2003
32
Prevalence of melanoma clinically resembling seborrheic keratosis: analysis of 9204 cases. (12472343)
2002
33
A pharmacokinetic evaluation of 0.5% and 5% fluorouracil topical cream in patients with actinic keratosis. (11440290)
2001
34
Sebaceous carcinoma arising on actinic keratosis. (10882948)
2000
35
Keratosis linearis with ichthyosis congenita and sclerosing keratoderma (KLICK-syndrome): a rare, autosomal recessive disorder of keratohyaline formation? (9188877)
1997
36
Role of endothelin-1 in hyperpigmentation in seborrhoeic keratosis. (8977712)
1996
37
Keratosis follicularis spinulosa decalvans. (20952906)
1995
38
Effect of a low-fat diet on the incidence of actinic keratosis. (8145782)
1994
39
Lectin histochemistry in psoriasis, lichen planus and seborrheic keratosis. (1299550)
1992
40
Human papillomavirus and seborrheic keratosis. (1659247)
1991
41
Trichilemmal tumor arising in a seborrheic keratosis: analysis of cell kinetics by BrdU staining. (1719052)
1991
42
Stereological study of desmosomes in basal cell carcinoma and seborrheic keratosis. (2955125)
1987
43
Langerhans' cells in seborrheic keratosis. A clinical and ultrastructural study. (2413689)
1985
44
Etretinate in treatment of actinic keratosis. A double-blind crossover study. (6120350)
1982
45
Evaluation of 5-fluorouracil in the treatment of actinic keratosis of the lip. (6946379)
1981
46
DNA-repair after UV-irradiation in skin fibroblasts from patients with actinic keratosis. (686819)
1978
47
Acridine orange-DNA complex in actinic keratosis. (70537)
1977
48
Inverted follicular keratosis. (1141446)
1975
49
A new X-linked recessive disorder with dwarfism, cerebral atrophy, and generalized keratosis follicularis. (4834251)
1974
50
KERATOSIS PALMO-PLANTARIS CONGENITA, WITH PERIODONTOSIS, ARACHNODACTYLY AND A PECULIAR DEFORMITY OF THE TERMINAL PHALANGES. (14252683)
1965

Genetic Variations for Keratosis

Expression for genes affiliated with Keratosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratosis

Search GEO for disease gene expression data for Keratosis.

Pathways for genes affiliated with Keratosis

Sources:
30KEGG, 38NCBI BioSystems Database, 54Reactome, 53R&D Systems
See all sources

Pathways related to Keratosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.6PIK3CA, FGFR3, BCL2, TP63
210.6PIK3CA, FGFR3, BCL2, TGFB2
310.5TGFB2, GHR, FGFR3
410.5DSG1, DSP
510.5TGFB2, BCL2

Compounds for genes affiliated with Keratosis

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
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Compounds related to Keratosis according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1serine4511.2GHR, ATP2A2, PIK3CA, CTSC, SAT1, DSP
2retinoic acid45 2412.2PIK3CA, GHR, DSP, DSG1, PCNA, CYP27B1
3calcium45 50 11 2414.1PIK3CA, ATP2A2, DSP, DSG1, CYP27B1, FGFR3
4arginine4511.1SAT1, CTSC, PIK3CA, GHR, PCNA, FGFR3
5paraffin4511.1TGFB2, GHR, PCNA, CYP27B1, FGFR3, KRT1
6progesterone45 60 29 11 2415.1PIK3CA, GHR, DSP, PCNA, KRT1, KRT10
7steroid4511.1PIK3CA, GHR, DSP, CYP27B1, SLURP1, KRT1
8tyrosine4511.1PIK3CA, GHR, DSP, CYP27B1, FGFR3, KRT1
9testosterone45 60 11 2414.1PIK3CA, GHR, PCNA, CYP27B1, SLURP1, KRT1
10bromodeoxyuridine4511.0PIK3CA, PCNA, KRT1, KRT10, TP63, TGFB2
11histidine4511.0CTSC, GHR, KRT10, TP63, TGFB2
125fluorouracil4511.0SAT1, PIK3CA, PCNA, BCL2, TGFB2
13hematoxylin4511.0PCNA, KRT1, KRT10, TP63
14oligonucleotide4511.0GHR, PCNA, CYP27B1, FGFR3, BCL2, TGFB2
15tamoxifen45 50 29 1114.0PIK3CA, GHR, PCNA, BCL2, TGFB2
16dexamethasone45 50 29 1114.0TGFB2, BCL2, PCNA, PIK3CA
17vegf4511.0PIK3CA, PCNA, FGFR3, BCL2, TP63, TGFB2
18genistein45 29 60 2 11 2415.9PIK3CA, PCNA, CYP27B1, BCL2, TGFB2
19lysine4510.9SAT1, CYP27B1, FGFR3, KRT1, TP63
20sulindac45 1111.9SAT1, PCNA, BCL2
21eb 108945 6011.9BCL2, CYP27B1, PCNA
22thapsigargin45 6011.9ATP2A2, DSP, PCNA, BCL2
23dutp4510.9PCNA, KRT10, BCL2
24arsenite45 2411.9PIK3CA, PCNA, SLURP1, BCL2
25cisplatin45 50 60 1113.9SAT1, PIK3CA, PCNA, BCL2, TP63
26calcitriol45 60 11 2413.9GHR, CYP27B1, KRT10, TGFB2
27resveratrol45 60 11 2413.9TGFB2
28thymidine45 2411.9PIK3CA, GHR, PCNA, TP63, TGFB2
29isoleucine4510.9KRT10, KRT1, GHR
30naphtho(1,2-b)furan-4,5-dione4510.9BCL2, PIK3CA
31vulm 14576010.8SAT1, KFSD
32ym 7506010.8SAT1, KFSD
33n1,n11-diethylnorspermine tetrahydrochloride6010.8SAT1, KFSD
34a 9225006010.8SAT1, KFSD
35retinoid4510.8CYP27B1, KRT1, KRT10, BCL2
36cycloheximide4510.8SAT1, GHR, CYP27B1, BCL2, TGFB2
37(r)-(+)-etomoxir sodium salt6010.8SAT1, KFSD
38cysteine4510.8CTSC, GHR, PCNA, CYP27B1, FGFR3, TGFB2
39eosin4510.7PCNA, KRT10
40vitamin d4510.7TGFB2, KRT10, CYP27B1, GHR
41tazarotene45 1111.6KRT1, KRT10
421,25 dihydroxy vitamin d34510.5TGFB2, KRT10, CYP27B1
43adpribose4510.5BCL2, PCNA, PIK3CA
44mitomycin c4510.4PCNA, BCL2, TP63
45p0034510.2TGFB2, TP63, GHR

GO Terms for genes affiliated with Keratosis

Sources:
16Gene Ontology
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Biological processes related to Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hair follicle morphogenesisGO:03106910.6TGFB2, TP63, BCL2
2keratinocyte differentiationGO:03021610.6TP63, KRT10, DSP
3digestive tract morphogenesisGO:04854610.5BCL2, FGFR3
4cell-cell adhesionGO:01633710.4DSP, DSG1, BCL2
5negative regulation of anoikisGO:200081110.2BCL2, PIK3CA

Molecular functions related to Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.8TGFB2, CTSC, PIK3CA, ATP2A2, GHR, DSP

Products for genes affiliated with Keratosis

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Sources for Keratosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet