MCID: KRT009
MIFTS: 53

Keratosis malady

Summaries for Keratosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Keratosis (from: keratinocyte, the prominent cell type in the epidermis and -osis, abnormal) a growth of... more...

MalaCards: Keratosis, also known as hyperkeratosis, is related to actinic keratosis and seborrheic keratosis. An important gene associated with Keratosis is SAT1 (spermidine/spermine N1-acetyltransferase 1), and among its related pathways are MicroRNAs in cancer and Pathways in cancer. The compounds serine and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and colon, and related mouse phenotypes are growth/size and immune system.

Aliases & Classifications for Keratosis

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

keratosis 8 10
hyperkeratosis 60


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Disease Ontology8 DOID:161
NCIt39 C34747
SNOMED-CT56 254666005
MeSH34 D007642

Related Diseases for Keratosis

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17GeneCards, 18GeneDecks
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Diseases related to Keratosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 408)
idRelated DiseaseScoreTop Affiliating Genes
1actinic keratosis31.7TP63, CYP27B1, PCNA, GHR
2seborrheic keratosis31.5PIK3CA, FGFR3
3squamous cell carcinoma31.1PIK3CA, ATP2A2, GHR, DSP, DSG1, PCNA
4keratosis follicularis31.0ATP2A2, MBTPS2, SAT1
5basal cell carcinoma31.0TP63, BCL2, KRT10, CYP27B1
6melanoma30.8SAT1, PIK3CA, GHR, DSG1, PCNA, CYP27B1
7palmoplantar keratosis30.7CTSC, DSG1, SLURP1
8lichen planus30.6KRT10, KRT1
9keratosis follicularis spinulosa decalvans30.4KFSD, SAT1
10alopecia30.3MBTPS2
11keratoacanthoma30.3KRT10, PCNA
12mongolian spot30.3DSP, ATP2A2
13epidermolysis bullosa simplex30.2KRT10, KRT1
14skin disease30.2ATP2A2, DSP, DSG1, FGFR3, SLURP1, KRT1
15psoriasis30.2CYP27B1, KRT1, KRT10
16adenocarcinoma30.0CTSC, PIK3CA, GHR, PCNA, CYP27B1, KRT1
17cholesteatoma30.0KRT10
18nonepidermolytic palmoplantar keratoderma30.0CTSC, DSG1, KRT1, KRT10
19ichthyosis, cyclic, with epidermolytic hyperkeratosis30.0KRT1, KRT10
20retinoblastoma29.9PIK3CA, PCNA, FGFR3, KRT10, BCL2, TGFB2
21papilloma29.9TP63, KRT10, FGFR3, PCNA
22leukoplakia29.9PCNA, KRT1
23epidermolytic hyperkeratosis29.9KRT1, KRT10
24osteosarcoma29.7TGFB2, CYP27B1, GHR
25epidermolysis bullosa29.7DSP
26hailey-hailey disease29.7DSP, ATP2A2
27breast cancer29.7SAT1, PIK3CA, DSP, PCNA, CYP27B1, FGFR3
28amyloidosis29.7KRT10
29sarcoma29.6DSP, DSG1, TP63
30inverted follicular keratosis10.6
31skin squamous cell carcinoma10.4
32in situ carcinoma10.4
33acanthoma10.2
34alopecia congenita keratosis palmoplantaris10.2
35hyperkeratosis lenticularis perstans10.2
36inflamed seborrheic keratosis10.2
37epidermodysplasia verruciformis10.2
38vulvar seborrheic keratosis10.2
39keratosis follicularis dwarfism and cerebral atrophy10.2
40keratosis palmoplantaris striata i, ad10.2
41keratosis follicularis spinulosa decalvans, x-linked10.2
42keratosis pilaris atrophicans10.2
43skin melanoma10.1
44keratosis palmoplantaris striata 310.1
45keratoderma palmoplantar deafness10.1
46hyperkeratosis-hyperpigmentation syndrome10.1
47acquired hyperkeratosis10.1
48verrucous carcinoma10.1
49keratosis palmoplantaris papulosa10.1
50keratosis focal palmoplantar gingival10.1

Graphical network of the top 20 diseases related to Keratosis:



Diseases related to keratosis

Clinical Features for Keratosis

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Drugs & Therapeutics for Keratosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Keratosis

Search NIH Clinical Center for Keratosis

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Genetic Tests for Keratosis

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Anatomical Context for Keratosis

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32MalaCards
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MalaCards organs/tissues related to Keratosis:

32
Skin, Breast, Colon, Liver, Testes, T cells, Kidney, Myeloid

Animal Models for Keratosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Keratosis:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537811.0TGFB2, SAT1, CTSC, PIK3CA, ATP2A2, GHR
2MP:000538710.9GHR, ATP2A2, PIK3CA, CTSC, PCNA, CYP27B1
3MP:000538910.9SAT1, PIK3CA, ATP2A2, GHR, PCNA, CYP27B1
4MP:000538410.9ATP2A2, PIK3CA, CTSC, SAT1, DSP, PCNA
5MP:001077110.8CTSC, PIK3CA, ATP2A2, CYP27B1, KRT1, BCL2
6MP:000200610.8SAT1, PIK3CA, ATP2A2, FGFR3, KRT10, BCL2
7MP:000537610.7CTSC, PIK3CA, ATP2A2, GHR, CYP27B1, FGFR3
8MP:000536710.6ATP2A2, GHR, CYP27B1, FGFR3, BCL2, TP63
9MP:001076810.6PIK3CA, ATP2A2, GHR, DSP, PCNA, FGFR3
10MP:000537510.5GHR, SAT1
11MP:000537910.3PIK3CA, GHR, CYP27B1, BCL2

Publications for Keratosis

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50PubMed
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Articles related to Keratosis:

(show top 50)    (show all 907)
idTitleAuthorsYear
1
Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling. (24335922)
2014
2
The roles of vitamin D in seborrhoeic keratosis: possible genetic and cellular signalling mechanisms. (23859137)
2013
3
Improvement of actinic keratosis associated with sunitinib therapy for metastatic renal cell carcinoma. (23432117)
2013
4
A comparison of patterns of disease extension in keratosis obturans and external auditory canal cholesteatoma. (23235551)
2013
5
Ingenol mebutate: a new option for actinic keratosis treatment. (23362492)
2013
6
Comparative study of actinic keratosis treatment with 3% diclofenac sodium and 5% 5-fluorouracil. (24173178)
2013
7
The usefulness of dermoscopy for the recognition of basal cell carcinoma--seborrhoeic keratosis compound tumours. (23043582)
2013
8
Reduced P53 Staining in Actinic Keratosis is Associated with Squamous Cell Carcinoma: A Preliminary Study. (23919015)
2013
9
Ingenol mebutate gel for actinic keratosis. (22417254)
2012
10
Actinic keratosis: a clinical and epidemiological revision. (22714759)
2012
11
Practice trends in the treatment of actinic keratosis in the United States: 0.5% fluorouracil and combination cryotherapy plus fluorouracil are underused despite evidence of benefit. (22513063)
2012
12
Epidermal growth factor receptor expression in mice skin upon ultraviolet B exposure - Seborrheic Keratosis as a coincidental and unique finding. (23326790)
2012
13
Pediatric onset keratosis lichenoides chronica: a case report. (22011337)
2012
14
Ingenol mebutate (Picato) for actinic keratosis. (22538622)
2012
15
Topical diclofenac gel for the management of periocular actinic keratosis. (21785377)
2012
16
Dermatological feasibility of multimodal facial color imaging modality for cross-evaluation of facial actinic keratosis. (20923462)
2011
17
A randomized comparative study of tolerance and satisfaction in the treatment of actinic keratosis of the face and scalp between 5% imiquimod cream and photodynamic therapy with methyl aminolaevulinate. (20973770)
2011
18
Unilateral keratosis pilaris atrophicans faciei mimicking follicular mucinosis. (21496685)
2011
19
Current and emerging treatment strategies for the treatment of actinic keratosis. (21437066)
2010
20
Medical image. Horn that does not adorn. Arsenical keratosis. (20186249)
2010
21
Widespread keratosis follicularis squamosa. (19196310)
2009
22
Pharmacotherapy of actinic keratosis. (19925043)
2009
23
Actinic keratosis: precancer, squamous cell carcinoma, or marker of field cancerization? (19755947)
2009
24
Seborrheic keratosis. (18801147)
2008
25
Dermoscopy of lichen planus-like keratosis: a model of inflammatory regression. (17958847)
2007
26
Case of keratosis lichenoides chronica with atypical sarcoidal granulomatous inflammation. (17204100)
2007
27
A case of follicular keratosis with trichostasis on an amputated limb. (16716178)
2006
28
Keratosis pilaris rubra: a common but underrecognized condition. (17178988)
2006
29
Dosing with 5% imiquimod cream 3 times per week for the treatment of actinic keratosis: results of two phase 3, randomized, double-blind, parallel-group, vehicle-controlled trials. (15837864)
2005
30
Clinical and dermoscopic image of an intermediate stage of regressing seborrheic keratosis in a lichenoid keratosis. (15720105)
2005
31
Expression of p53, bcl-2 and growth hormone receptor in atrophic type of actinic keratosis. (14757281)
2004
32
Lidocaine iontophoresis versus EMLA cream for CO2 laser treatment in seborrheic keratosis. (16083154)
2004
33
Expression of p53, bcl-2 and growth hormone receptor in actinic keratosis, hypertrophic type. (12756585)
2003
34
Benign lymphangioendothelioma manifested clinically as actinic keratosis. (11204600)
2001
35
Expression of EGFR in keratosis of laryngeal and the correlation with malignant phenotype]. (12541405)
2000
36
Expression of matrix metalloproteinase-1, -2 and -3 in squamous cell carcinoma and actinic keratosis. (10362121)
1999
37
Occult basal cell carcinoma arising in seborrheic keratosis. (9675344)
1998
38
Globulelike dermoscopic structures in pigmented seborrheic keratosis. (9126023)
1997
39
Actinic keratosis and squamous cell carcinoma. (8116516)
1994
40
Keratosis pilaris and scarring alopecia. Keratosis follicularis spinulosa decalvans. (1550376)
1992
41
Large-cell acanthoma. A distinctive keratosis. (1348913)
1992
42
Benign pigmented tumor with combined features of seborrheic keratosis and compound nevus. (1836990)
1991
43
Seborrheic keratosis of the ear canal. (2960940)
1987
44
An acantholytic variant of seborrheic keratosis. (2946737)
1986
45
Characterization of a new type of human papillomavirus (HPV) related to HPV5 from a case of actinic keratosis. (3020786)
1986
46
Seborrheic keratosis? (3965523)
1985
47
Giant irritated seborrheic keratosis mimicking verrucous carcinoma. (3910690)
1985
48
Keratosis punctata palmaris et plantaris and adenocarcinoma of the colon. A possible familial association of punctate keratoderma and gastrointestinal malignancy. (6232299)
1984
49
Trichilemmal differentiation in seborrheic keratosis. (6458629)
1981
50
Keratosis follicularis spinulosa decalvans. An infant with failure to thrive, deafness, and recurrent infections. (646399)
1978

Genetic Variations for Keratosis

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Expression for genes affiliated with Keratosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keratosis

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Pathways for genes affiliated with Keratosis

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29KEGG, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems
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Pathways related to Keratosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.6TP63, BCL2, FGFR3, PIK3CA
210.6TGFB2, BCL2, FGFR3, PIK3CA
310.5GHR, FGFR3, TGFB2
410.5DSG1, DSP
510.5TGFB2, BCL2

Compounds for genes affiliated with Keratosis

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Keratosis according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1serine4411.2GHR, ATP2A2, PIK3CA, CTSC, SAT1, DSP
2retinoic acid44 2412.2PIK3CA, GHR, DSP, DSG1, PCNA, CYP27B1
3calcium44 49 11 2414.1PIK3CA, ATP2A2, DSP, DSG1, CYP27B1, FGFR3
4arginine4411.1SAT1, CTSC, PIK3CA, GHR, PCNA, FGFR3
5paraffin4411.1TGFB2, GHR, PCNA, CYP27B1, FGFR3, KRT1
6progesterone44 59 28 11 2415.1PIK3CA, GHR, DSP, PCNA, KRT1, KRT10
7steroid4411.1PIK3CA, GHR, DSP, CYP27B1, SLURP1, KRT1
8tyrosine4411.1PIK3CA, GHR, DSP, CYP27B1, FGFR3, KRT1
9testosterone44 59 11 2414.1PIK3CA, GHR, PCNA, CYP27B1, SLURP1, KRT1
10bromodeoxyuridine4411.0PIK3CA, PCNA, KRT1, KRT10, TP63, TGFB2
11histidine4411.0CTSC, GHR, KRT10, TP63, TGFB2
125fluorouracil4411.0SAT1, PIK3CA, PCNA, BCL2, TGFB2
13hematoxylin4411.0PCNA, KRT1, KRT10, TP63
14oligonucleotide4411.0GHR, PCNA, CYP27B1, FGFR3, BCL2, TGFB2
15tamoxifen44 49 28 1114.0PIK3CA, GHR, PCNA, BCL2, TGFB2
16dexamethasone44 49 28 1114.0TGFB2, BCL2, PCNA, PIK3CA
17vegf4411.0PIK3CA, PCNA, FGFR3, BCL2, TP63, TGFB2
18genistein44 28 59 2 11 2415.9PIK3CA, PCNA, CYP27B1, BCL2, TGFB2
19lysine4410.9SAT1, CYP27B1, FGFR3, KRT1, TP63
20sulindac44 1111.9SAT1, PCNA, BCL2
21eb 108944 5911.9BCL2, CYP27B1, PCNA
22thapsigargin44 5911.9ATP2A2, DSP, PCNA, BCL2
23dutp4410.9PCNA, KRT10, BCL2
24arsenite44 2411.9PIK3CA, PCNA, SLURP1, BCL2
25cisplatin44 49 59 1113.9SAT1, PIK3CA, PCNA, BCL2, TP63
26calcitriol44 59 11 2413.9GHR, CYP27B1, KRT10, TGFB2
27resveratrol44 59 11 2413.9TGFB2
28thymidine44 2411.9PIK3CA, GHR, PCNA, TP63, TGFB2
29isoleucine4410.9KRT10, KRT1, GHR
30naphtho(1,2-b)furan-4,5-dione4410.9BCL2, PIK3CA
31vulm 14575910.8SAT1, KFSD
32ym 7505910.8SAT1, KFSD
33n1,n11-diethylnorspermine tetrahydrochloride5910.8SAT1, KFSD
34a 9225005910.8SAT1, KFSD
35retinoid4410.8CYP27B1, KRT1, KRT10, BCL2
36cycloheximide4410.8SAT1, GHR, CYP27B1, BCL2, TGFB2
37(r)-(+)-etomoxir sodium salt5910.8SAT1, KFSD
38cysteine4410.8CTSC, GHR, PCNA, CYP27B1, FGFR3, TGFB2
39eosin4410.7PCNA, KRT10
40vitamin d4410.7TGFB2, KRT10, CYP27B1, GHR
41tazarotene44 1111.6KRT1, KRT10
421,25 dihydroxy vitamin d34410.5TGFB2, KRT10, CYP27B1
43adpribose4410.5BCL2, PCNA, PIK3CA
44mitomycin c4410.4PCNA, BCL2, TP63
45p0034410.2TGFB2, TP63, GHR

GO Terms for genes affiliated with Keratosis

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16Gene Ontology
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Biological processes related to Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hair follicle morphogenesisGO:03106910.6TGFB2, TP63, BCL2
2keratinocyte differentiationGO:03021610.6TP63, KRT10, DSP
3digestive tract morphogenesisGO:04854610.5BCL2, FGFR3
4cell-cell adhesionGO:01633710.4DSP, DSG1, BCL2
5negative regulation of anoikisGO:200081110.2BCL2, PIK3CA

Molecular functions related to Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.8TGFB2, CTSC, PIK3CA, ATP2A2, GHR, DSP

Products for genes affiliated with Keratosis

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Sources for Keratosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet