MCID: KRT036
MIFTS: 46

Keratosis, Seborrheic, Somatic malady

Categories: Genetic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Keratosis, Seborrheic, Somatic

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Aliases & Descriptions for Keratosis, Seborrheic, Somatic:

Name: Keratosis, Seborrheic, Somatic 51 12
Keratosis, Seborrheic 47 69 26 38
Seborrheic Keratosis 11 49 13 67
 
Keratosis Seborrheica 47
Seborrheic Keratoses 47
Kerseb 69

Characteristics:

HPO:

63
keratosis, seborrheic, somatic:
Inheritance: autosomal dominant inheritance

Classifications:



External Ids:

OMIM51 182000
Disease Ontology11 DOID:6498
ICD1029 L82, L82.1
ICD9CM31 702.1
MeSH38 D017492
NCIt44 C9006
MedGen36 C0022603

Summaries for Keratosis, Seborrheic, Somatic

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UniProtKB/Swiss-Prot:69 Keratosis, seborrheic: A common benign skin tumor. Seborrheic keratoses usually begin with the appearance of one or more sharply defined, light brown, flat macules. The lesions may be sparse or numerous. As they initially grow, they develop a velvety to finely verrucous surface, followed by an uneven warty surface with multiple plugged follicles and a dull or lackluster appearance.

MalaCards based summary: Keratosis, Seborrheic, Somatic, also known as keratosis, seborrheic, is related to syringoma and vulvar seborrheic keratosis, and has symptoms including verrucae, leser-trélat sign and leser-trélat sign. An important gene associated with Keratosis, Seborrheic, Somatic is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways are Immune response IFN gamma signaling pathway and Chronic myeloid leukemia. Affiliated tissues include skin, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

OMIM:51 Seborrheic keratoses are common benign epidermal lesion that can develop on any part of the body. (182000) more...

Related Diseases for Keratosis, Seborrheic, Somatic

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Diseases related to Keratosis, Seborrheic, Somatic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1syringoma30.1CLEC2A, KRT10
2vulvar seborrheic keratosis12.3
3inflamed seborrheic keratosis12.2
4inverted follicular keratosis11.8
5dermatosis papulosa nigra11.4
6melanoacanthoma11.3
7clear cell acanthoma11.3
8actinic keratosis11.3
9keratosis11.0
10epidermal nevus, somatic10.6FGFR3, PIK3CA
11pancreatitis, pediatric10.5MTOR, PIK3CA
12complex lethal osteochondrodysplasia10.5KRT10, PIK3CA
13hemochromatosis type 210.5MTOR, PIK3CA
14metatypical basal cell carcinoma10.5KRT10, KRT17
15basal cell carcinoma10.5
16craniodiaphyseal dysplasia, autosomal dominant10.5KRT10, KRT17
17malignant cystic nephroma10.4KRT10, KRT5
18gastric squamous cell carcinoma10.4KRT10, KRT5
19spongiotic dermatitis10.4FGFR3, MTOR, PIK3CA
20follicular basal cell carcinoma10.4CLEC2A, KRT17
21epidermolysis bullosa simplex-mp10.3KRT10, KRT5
22pseudoangiomatous stromal hyperplasia10.3PIK3CA, TP53
23pneumonia10.3KRT10, KRT5
24urethra clear cell adenocarcinoma10.3MTOR, PIK3CA
25pasli disease10.3FGFR3, TP53
26malignant epithelial mesothelioma10.3KRT10, KRT5
27familial renal oncocytoma10.3FGFR3, TP53
28scrapie10.3FGFR3, TP53
29intrahepatic bile duct adenoma10.3FGFR3, TP53
30kidney sarcoma10.2PIK3CA, TP53
31hemoglobin d disease10.2KRT10, KRT17, KRT5
32colorectal adenomatous polyposis, autosomal recessive, with pilomatricomas10.2KRT10, KRT17, KRT5
33lissencephaly10.2KRT10, KRT17, KRT5
34ichthyosis, cyclic, with epidermolytic hyperkeratosis10.2KRT10, KRT17, KRT5
35familial retinoblastoma10.2KRT10, KRT17, KRT5
36adenosquamous carcinoma10.2FGFR3, PIK3CA
37liver lymphoma10.1KRT17, TP53
38ureter squamous cell carcinoma10.1KRT5, TP53
39stampe sorensen syndrome10.1PIK3CA, TP53
40epidermodysplasia verruciformis10.1
41glomangioma10.1CLEC2A, TP53
42penis carcinoma in situ10.1FGFR3, PIK3CA, TP53
43congenital myasthenic syndrome10.1KRT5, TP53
44papillary adenofibroma10.0MTOR, PIK3CA, TP53
45acanthoma10.0
46bowen's disease10.0
47gigantism10.0
48x-linked congenital generalized hypertrichosis10.0KRT17, TP53
49progesterone-receptor positive breast cancer10.0MTOR, PIK3CA, TP53
50ovarian small cell carcinoma10.0PIK3CA, TP53

Comorbidity relations with Keratosis, Seborrheic, Somatic via Phenotypic Disease Network (PDN):


Hypertension, EssentialKeratosis

Graphical network of the top 20 diseases related to Keratosis, Seborrheic, Somatic:



Diseases related to keratosis, seborrheic, somatic

Symptoms for Keratosis, Seborrheic, Somatic

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Symptoms by clinical synopsis from OMIM:

182000

Clinical features from OMIM:

182000

Human phenotypes related to Keratosis, Seborrheic, Somatic:

 63
id Description HPO Frequency HPO Source Accession
1 verrucae63 HP:0200043

UMLS symptoms related to Keratosis, Seborrheic, Somatic:


leser-trélat sign

Drugs & Therapeutics for Keratosis, Seborrheic, Somatic

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Drugs for Keratosis, Seborrheic, Somatic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Pharmaceutical SolutionsPhase 3, Phase 2, Phase 17793
2
Lidocaineapproved, vet_approved1226137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bio-0767
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Cuivasil
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
DermaFlex
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gravocain
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
 
LS-805
Lanabiotic
Leostesin
Lida-Mantle
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocainum
Lidocainum [INN-Latin]
Lidocaton
Lidoderm
Lidoject-1
Lidoject-2
Lignocaine
Lignocainum
Lingocaine
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Octocaine
Octocaine-100
Octocaine-50
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-MPF
Xylocaine-MPF with Glucose
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
3
Epinephrineapproved, vet_approved93351-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
4Racepinephrine933
5Anesthetics9001
6Epinephryl borate933

Interventional clinical trials:

(show all 13)
idNameStatusNCT IDPhase
1A Study of A-101 Solution 40% in Subjects With Seborrheic Keratosis.CompletedNCT02667236Phase 3
2A Randomized, Double-Blind, Vehicle-Controlled Study in Subjects With Seborrheic KeratosisCompletedNCT02667275Phase 3
3An Open-Label Safety Study of A-101 SolutionCompletedNCT02667288Phase 3
4Dose-Response Profile of A-101 in Subjects With Seborrheic KeratosisUnknown statusNCT02160626Phase 2
5Study to Evaluate the Safety and Efficacy of PEP005(Ingenol Mebutate) Gel, 0.05%, in Patients With Seborrhoeic KeratosisCompletedNCT01214564Phase 2
6Study of A-101 for the Treatment of Seborrheic KeratosisCompletedNCT02260180Phase 2
7Study of Safety, Tolerability and Effectiveness of A-101 in Subjects With Seborrheic KeratosisCompletedNCT01986920Phase 1, Phase 2
8Is Cryosurgery or Curettage More Effective at Treating Seborrheic Keratoses?Unknown statusNCT01159860
9In-vivo Optical Coherence Tomography Imaging in DermatooncologyUnknown statusNCT01680562
10Dermatosis Papulosa NigraCompletedNCT00710203
11Optical Biopsy of Human Skin in Conjunction With Laser TreatmentCompletedNCT00540566
12Analysis of Melanocytes (Pigment Cells) in Sun-Exposed SkinCompletedNCT00875381
13Electrocautery vs Q-switch for Seborrheic KeratosisWithdrawnNCT02366559

Search NIH Clinical Center for Keratosis, Seborrheic, Somatic


Cochrane evidence based reviews: keratosis, seborrheic

Genetic Tests for Keratosis, Seborrheic, Somatic

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Genetic tests related to Keratosis, Seborrheic, Somatic:

id Genetic test Affiliating Genes
1 Keratosis, Seborrheic26

Anatomical Context for Keratosis, Seborrheic, Somatic

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MalaCards organs/tissues related to Keratosis, Seborrheic, Somatic:

35
Skin

Animal Models for Keratosis, Seborrheic, Somatic or affiliated genes

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MGI Mouse Phenotypes related to Keratosis, Seborrheic, Somatic:

40 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.0FGFR3, RBP1, SALL1, TGFB2, TP53
2MP:00053719.0FGFR3, KRT5, SALL1, TGFB2, TP53
3MP:00011868.6KRT17, MCM2, RBP1, TP53
4MP:00030128.2FGFR3, KRT17, KRT5, MTOR, OSMR, PIK3CA
5MP:00053758.2MCM2, MTOR, OSMR, PIK3CA, TP53
6MP:00107717.7FGFR3, KRT17, KRT5, MCM2, OSMR, PIK3CA
7MP:00053817.6FGFR3, KRT17, KRT5, MCM2, SALL1, TGFB2
8MP:00053797.6MCM2, MTOR, OSMR, PIK3CA, RBP1, TGFB2
9MP:00053847.6FGFR3, KRT17, MCM2, MTOR, PIK3CA, SALL1
10MP:00053877.3FGFR3, MCM2, MTOR, OSMR, PIK3CA, RBP1
11MP:00036317.3FGFR3, MCM2, MTOR, PIK3CA, RBP1, SALL1
12MP:00053867.2FGFR3, KRT5, MCM2, MTOR, OSMR, PIK3CA
13MP:00053786.1FGFR3, KRT17, KRT5, MCM2, MTOR, OSMR

Publications for Keratosis, Seborrheic, Somatic

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Variations for Keratosis, Seborrheic, Somatic

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UniProtKB/Swiss-Prot genetic disease variations for Keratosis, Seborrheic, Somatic:

69 (show all 11)
id Symbol AA change Variation ID SNP ID
1FGFR3p.Arg248CysVAR_004148rs121913482
2FGFR3p.Ser249CysVAR_004149rs121913483
3FGFR3p.Gly370CysVAR_004151rs121913479
4FGFR3p.Ser371CysVAR_004152rs121913484
5FGFR3p.Tyr373CysVAR_004153rs121913485
6FGFR3p.Lys650GluVAR_004160rs78311289
7FGFR3p.Lys650MetVAR_004161rs121913105
8PIK3CAp.Glu542LysVAR_026173rs121913273
9PIK3CAp.Glu545GlyVAR_026177rs121913274
10PIK3CAp.Glu545LysVAR_026178rs104886003
11PIK3CAp.His1047ArgVAR_026192rs121913279

Clinvar genetic disease variations for Keratosis, Seborrheic, Somatic:

5
id Gene Variation Type Significance SNP ID Assembly Location
1PIK3CANM_006218.3(PIK3CA): c.3140A> G (p.His1047Arg)SNVPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
2PIK3CANM_006218.3(PIK3CA): c.1633G> A (p.Glu545Lys)SNVPathogenicrs104886003GRCh37Chr 3, 178936091: 178936091
3FGFR3NM_000142.4(FGFR3): c.742C> T (p.Arg248Cys)SNVPathogenicrs121913482GRCh37Chr 4, 1803564: 1803564
4FGFR3NM_000142.4(FGFR3): c.746C> G (p.Ser249Cys)SNVPathogenicrs121913483GRCh37Chr 4, 1803568: 1803568

Expression for genes affiliated with Keratosis, Seborrheic, Somatic

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Search GEO for disease gene expression data for Keratosis, Seborrheic, Somatic.

Pathways for genes affiliated with Keratosis, Seborrheic, Somatic

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Pathways related to Keratosis, Seborrheic, Somatic according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.3FGFR3, MTOR, PIK3CA, TGFB2
2
Show member pathways
9.3PIK3CA, TGFB2, TP53
3
Show member pathways
9.3MTOR, PIK3CA, TP53
49.3MTOR, PIK3CA, TP53
5
Show member pathways
9.2FGFR3, MTOR, TP53
69.1KRT17, KRT5, TP53
7
Show member pathways
9.1MTOR, OSMR, TP53
89.0FGFR3, MTOR, PIK3CA, TP53
9
Show member pathways
9.0FGFR3, MTOR, PIK3CA, TP53
10
Show member pathways
9.0MTOR, PIK3CA, TGFB2, TP53
119.0MTOR, PIK3CA, TGFB2, TP53
12
Show member pathways
9.0MTOR, PIK3CA, TGFB2, TP53
138.7FGFR3, MTOR, PIK3CA, TGFB2, TP53
148.7FGFR3, MTOR, PIK3CA, TGFB2, TP53
158.5FGFR3, MTOR, OSMR, PIK3CA, TP53

GO Terms for genes affiliated with Keratosis, Seborrheic, Somatic

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Cellular components related to Keratosis, Seborrheic, Somatic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol 3-kinase complexGO:000594210.1MTOR, PIK3CA
2intermediate filamentGO:00058829.4KRT10, KRT17, KRT5

Biological processes related to Keratosis, Seborrheic, Somatic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heart valve morphogenesisGO:000317910.3MTOR, TGFB2
2embryonic digestive tract developmentGO:00485669.9SALL1, TGFB2
3phosphatidylinositol-mediated signalingGO:00480159.9FGFR3, MTOR, PIK3CA
4hair follicle morphogenesisGO:00310699.9KRT17, TGFB2
5cell cycle arrestGO:00070509.2MTOR, TGFB2, TP53

Sources for Keratosis, Seborrheic, Somatic

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
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44NCIt
45NDF-RT
48NINDS
49Novoseek
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52OMIM via Orphanet
56PubMed
57QIAGEN
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66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet