Kernicterus disease: drugs, articles, genes, clinical trials

Summaries for Kernicterus

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⁴⁴Wikipedia, ²²MalaCards
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Wikipedia: Kernicterus is a bilirubin-induced brain dysfunction. Bilirubin is a highly neurotoxic substance that...⁴⁴ more...

MalaCards: Kernicterus, also known as bilirubin encephalopathy, is related to hereditary spherocytosis and crigler najjar syndrome, type 2. An important gene associated with Kernicterus is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Sorafenib Pharmacokinetics and Nicotine Pathway, Pharmacokinetics. The compounds n-acetylbenzidine and flurbiprofen have been mentioned in the context of this disorder. Affiliated tissues include brain and globus pallidus.

Aliases & Descriptions for Kernicterus

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²CDC, ⁶Disease Ontology, ³⁰NIH Rare Diseases, ⁸DISEASES, ³²Novoseek , ⁴³UMLS, ²⁷NCIt, ⁴⁰SNOMED-CT, ²⁴MeSH
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Aliases & Descriptions:

kernicterus ⁶ ³⁰ ⁸ ³² ⁴³

bilirubin encephalopathy ⁶ ³⁰

kernicterus of newborn nos (disorder) ⁶

kernicterus (morphologic abnormality) ⁶

hyperbilirubinemic encephalopathy ³⁰

kernicterus of newborn (disorder) ⁶

kernicterus of newborn nos ⁶

External Ids:

NCIt²⁷ C84799

SNOMED-CT⁴⁰ 74925009, 268880009, 157135006 50143004, 230770008, 206479002, more

MeSH²⁴ D007647

UMLS⁴³ C0022610

Related Diseases for Kernicterus

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Sources:
¹³GeneCards, ¹⁴GeneDecks
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Diseases related to kernicterus by text searches and GeneDecks gene sharing:

(show all 45)

id	Related Disease	Score	Top Affiliating Genes
1	hereditary spherocytosis	27.4	UGT1A1, RHD, G6PD
2	crigler najjar syndrome, type 2	27.4	UGT1A9, UGT1A6, UGT1A4, UGT1A1
3	spherocytosis	27.4	G6PD, RHD, UGT1A1
4	jaundice	26.8	UGT1A1, UGT1A4, ALB, RHD, G6PD
5	acute diarrhea	13.3	G6PD, ALB
6	glucosephosphate dehydrogenase deficiency	13.3	UGT1A1, G6PD
7	beta thalassemia	13.3	G6PD, UGT1A1
8	alpha thalassemia	13.2	UGT1A1, G6PD
9	choledocholithiasis	13.1	ALB, UGT1A1
10	gilbert syndrome	13.0	G6PD, UGT1A7, UGT1A4, UGT1A1
11	sickle cell anemia	12.9	UGT1A1, ALB, G6PD
12	cholelithiasis	12.8	UGT1A1, UGT1A6, G6PD
13	drug-induced hepatitis	12.7	ALB, UGT1A6, UGT1A3, UGT1A1
14	neonatal jaundice	12.7	G6PD, RHD, UGT1A1
15	hydrops fetalis	12.6	ALB, RHD, G6PD
16	crigler-najjar syndrome	12.6	UGT1A9, UGT1A6, UGT1A4, UGT1A1
17	hemolytic anemia	12.6	UGT1A1, RHD, G6PD
18	hereditary elliptocytosis	12.6	RHD, G6PD
19	fascioliasis	12.5	UGT3A2, UGT3A1, UGT2A3, UGT2A1
20	diarrhea	12.5	UGT1A1, UGT1A6, ALB, G6PD, SLC35A2
21	bilirubin metabolic disorder	12.5	G6PD, ABCC1, ALB, UGT1A7, UGT1A1
22	cholestasis	12.5	UGT1A3, ALB, ABCC1, G6PD
23	leukopenia	12.5	UGT1A1, ALB, ABCC1
24	dubin-johnson syndrome	12.5	UGT1A1, ABCC1
25	familial adenomatous polyposis	12.4	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6
26	sickle cell disease	12.4	G6PD, RHD, ALB, UGT1A1
27	rh isoimmunization	12.4	RHCE, RHD
28	thalassemia	12.3	G6PD, RHD, ALB, UGT1A1
29	fetal erythroblastosis	12.3	RHCE, RHD, G6PD
30	polyposis	12.2	ALB, UGT1A6, UGT1A4, UGT1A3, UGT1A10, UGT1A1
31	autoimmune hemolytic anemia	12.2	G6PD, RHD, RHCE
32	liver cirrhosis	11.9	ABCC1, RHD, ALB, UGT1A7
33	neutropenia	11.8	ABCC1, ALB, UGT1A9, UGT1A7, UGT1A6, UGT1A1
34	duodenitis	11.6	G6PD, ABCC1, ALB, UGT1A6, UGT1A4, UGT1A3
35	colon cancer	11.2	SLC35A2, ABCC1, ALB, UGT1A9, UGT1A7, UGT1A6
36	galactosemia	11.2	G6PD, ABCC1, ALB, UGT1A9, UGT1A7, UGT1A6
37	hearing loss	10.6	UGT1A5, UGT1A4, UGT1A3, UGT1A10, UGT1A1, UGT1A6
38	aldosteronism	10.3	ALB, UGT2B28, UGT2A3, UGT2A1, UGT1A9, UGT1A8
39	colorectal cancer	9.7	SLC35A2, G6PD, ABCC1, RHD, ALB, UGT3A2
40	cholesterol	9.5	UGT2A1, UGT2A3, UGT2B28, ALB, ABCC1, G6PD
41	hepatitis	8.9	SLC35A2, G6PD, ABCC1, RHD, PNKD, ALB
42	kernicterus due to isoimmunization	8.3
43	cerebral palsy athetoid	6.5
44	sepsis	6.5
45	lucey-driscoll syndrome	5.6

Graphical network of the top 20 diseases related to kernicterus:

Graphical network of diseases related to kernicterus

Clinical Features for Kernicterus

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Drugs & Therapeutics for Kernicterus

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Sources:
⁴CenterWatch, ²⁹NIH Clinical Center, ⁵ClinicalTrials, ⁴³UMLS, ²⁸NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Kernicterus

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Anatomical Context for Kernicterus

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²²MalaCards
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MalaCards organs/tissues related to kernicterus:

²²

Brain, Globus pallidus

Phenotypes for genes affiliated with Kernicterus

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Publications for genes affiliated with Kernicterus

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³⁵PubMed
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Articles related to kernicterus:

(show all 20)

id	Title	Authors	Year	Affiliating Genes
1	Clinical report from the pilot USA Kernicterus Registry (1992 to 2004). (19177057)	Johnson L.... Shapiro S.M.	2009	G6PD
2	Fatal kernicterus in a girl deficient in glucose-6-phosphate dehydrogenase: a paradigm of synergistic heterozygosity. (19324225)	Zangen S.... Kaplan M.	2009	G6PD
3	A new animal model of hemolytic hyperbilirubinemia-induced bilirubin encephalopathy (kernicterus). (18458656)	Rice A.C.... Shapiro S.M.	2008	ALB
4	Kernicterus by glucose-6-phosphate dehydrogenase deficiency: a case report and review of the literature. (18460213)	de Gurrola G.C.... Meraz E.A.	2008	G6PD
5	Genetic factors in neonatal hyperbilirubinemia and kernicterus. (17990575)	Sarici S.U.... Saldir M.	2007	UGT1A1
6	Glucose-6-phosphate dehydrogenase deficiency and kernicterus of South-East anatolia. (17483701)	Katar S.	2007	G6PD
7	Kernicterus associated with hereditary spherocytosis and UGT1A1 promoter polymorphism. (16735790)	Berardi A.... Iolascon A.	2006	UGT1A1
8	Management of hyperbilirubinemia and prevention of kernicterus in 20 patients with Crigler-Najjar disease. (16435131)	Strauss K.A.... Morton D.H.	2006	ALB
9	Glucose-6-phosphate dehydrogenase deficiency: a hidden risk for kernicterus. (15686267)	Kaplan M.... Hammerman C.	2004	G6PD
10	Kernicterus and G6PD deficiency--a case series from Oman. (12729287)	Nair P.A.... Al Khusaiby S.M.	2003	G6PD
11	Changes in globus pallidus with (pre)term kernicterus. (14654594)	Govaert P.... Barkovich J.	2003	G6PD
12	Glucose-6-phosphate dehydrogenase deficiency: a potential source of severe neonatal hyperbilirubinaemia and kernicterus. (12208096)	Kaplan M.... Hammerman C.	2002	G6PD
13	Interaction of coding region mutations and the Gilbert-type promoter abnormality of the UGT1A1 gene causes moderate degrees of unconjugated hyperbilirubinaemia and may lead to neonatal kernicterus. (11370628)	Kadakol A.... Chowdhury N.R.	2001	UGT1A1, UGT1A9
14	Glucose 6-phosphate dehydrogenase deficiency with kernicterus: progressive late recovery from profound deafness. (9578122)	Akhtar S.... Graham J.	1998	G6PD
15	Current drug treatment options in neonatal hyperbilirubinaemia and the prevention of kernicterus. (9664196)	Rubaltelli F.F.	1998	G6PD
16	A case of kernicterus in New Zealand: a predictable tragedy? (9401895)	Stanley T.V.	1997	G6PD
17	Hemolytic jaundice due to G6PD deficiency causing kernicterus in a female newborn. (7597488)	Washington E.C.... Holden K.	1995	G6PD
18	Index of suspicion. Case 3. Kernicterus in a baby girl homozygous for glucose-6-phosphate dehydrogenase deficiency. (8493190)	Oblender M.	1993	G6PD
19	Clinical study on the prevention of kernicterus caused by hereditary glucose-6-phosphate dehydrogenase deficiency (1332814)	Du C.S.	1992	G6PD
20	Deposition of bilirubin acid in the central nervous system--a hypothesis for the development of kernicterus. (2180252)	Brodersen R.... Stern L.	1990	ALB

Genes related to Kernicterus

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¹³GeneCards
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Genes related to kernicterus according to GeneCards:

(show all 21)

id	Symbol	Description	Score	GeneCards Section Context
1	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
2	UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1	11.0	Publications
3	ALB	albumin	11.0	Publications
4	UGT1A5	UDP glucuronosyltransferase 1 family, polypeptide A5	11.0
5	SLC35A2	solute carrier family 35 (UDP-galactose transporter), member A2	11.0
6	UGT2B28	UDP glucuronosyltransferase 2 family, polypeptide B28	11.0
7	UGT1A4	UDP glucuronosyltransferase 1 family, polypeptide A4	11.0
8	UGT2A1	UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus	11.0
9	UGT3A2	UDP glycosyltransferase 3 family, polypeptide A2	11.0
10	UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	11.0
11	UGT1A10	UDP glucuronosyltransferase 1 family, polypeptide A10	11.0
12	UGT3A1	UDP glycosyltransferase 3 family, polypeptide A1	11.0	Disorders
13	UGT2A3	UDP glucuronosyltransferase 2 family, polypeptide A3	11.0
14	UGT1A9	UDP glucuronosyltransferase 1 family, polypeptide A9	11.0	Publications
15	UGT1A8	UDP glucuronosyltransferase 1 family, polypeptide A8	11.0
16	UGT1A7	UDP glucuronosyltransferase 1 family, polypeptide A7	11.0
17	PNKD	paroxysmal nonkinesigenic dyskinesia	11.0
18	UGT1A6	UDP glucuronosyltransferase 1 family, polypeptide A6	11.0
19	RHCE	Rh blood group, CcEe antigens	11.0
20	RHD	Rh blood group, D antigen	11.0
21	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	11.0

Expression for genes affiliated with Kernicterus

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¹BioGPS
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Expression patterns in normal tissues for genes affiliated with Kernicterus

Pathways for genes affiliated with Kernicterus

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Sources:
³⁴PharmGKB, ⁴¹Thomson Reuters, ¹⁰EMD Millipore, ³⁸Reactome, ²⁰KEGG
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Pathways related to kernicterus according to GeneDecks:

(show all 33)

id	Pathway	Score	Top Affiliating Genes
1	Sorafenib Pharmacokinetics³⁴	10.1	UGT1A9, UGT1A1
2	Nicotine Pathway, Pharmacokinetics³⁴	10.0	UGT1A4, UGT1A9
3	Estradiol metabolism⁴¹	10.0	UGT2B28, UGT1A10, UGT1A1
4	Estradiol metabolism¹⁰	9.9	UGT2B28, UGT1A10, UGT1A1
5	Fluvastatin Pathway, Pharmacokinetics³⁴	9.9	UGT1A3, UGT1A1
6	Benzodiazepine Pathway, Pharmacokinetics³⁴	9.9	UGT1A4, UGT1A9
7	Glucuronidation³⁸	9.8	UGT1A1, UGT1A4, UGT1A6
8	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics³⁴	9.8	UGT1A1, ABCC1
9	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics³⁴	9.7	UGT1A1, UGT1A3
10	Tamoxifen Pathway, Pharmacokinetics³⁴	9.6	UGT1A10, UGT1A3, UGT1A4, UGT1A8
11	Benzo[a]pyrene metabolism⁴¹	9.5	UGT1A9, UGT1A6, UGT1A10
12	Benzo[a]pyrene metabolism¹⁰	9.5	UGT1A9, UGT1A6, UGT1A10
13	Phenytoin Pathway, Pharmacokinetics³⁴	9.4	UGT1A9, UGT1A6, UGT1A4, UGT1A1
14	Irinotecan Pathway, Pharmacokinetics³⁴	9.4	UGT1A1, UGT1A10, UGT1A9, ABCC1
15	Estrogen Metabolism Pathway³⁴	9.4	UGT1A1, UGT1A3, UGT1A4, UGT1A8, UGT1A9
16	Mycophenolic acid Pathway, Pharmacokinetics³⁴	9.3	UGT1A9, UGT1A8, UGT1A7, UGT1A10
17	Acetaminophen metabolism⁴¹	9.2	UGT1A9, UGT1A6, UGT1A3, UGT1A10, UGT1A1
18	Acetaminophen metabolism¹⁰	9.2	UGT1A1, UGT1A10, UGT1A3, UGT1A6, UGT1A9
19	2-Naphthylamine and 2-Nitronaphtalene metabolism¹⁰	8.9	UGT1A9, UGT1A8, UGT1A6, UGT1A4, UGT1A3, UGT1A1
20	2-Naphthylamine and 2-Nitronaphtalene metabolism⁴¹	8.9	UGT1A9, UGT1A8, UGT1A6, UGT1A4, UGT1A3, UGT1A1
21	Valproic Acid Pathway, Pharmacokinetics³⁴	8.8	UGT1A9, UGT1A8, UGT1A6, UGT1A4, UGT1A3, UGT1A10
22	Irinotecan Pathway, Pharmacodynamics³⁴	8.6	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A8
23	Porphyrin and chlorophyll metabolism²⁰	7.3	UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1
24	Ascorbate and aldarate metabolism²⁰	7.3	UGT2A1, UGT2A3, UGT2B28, UGT1A9, UGT1A8, UGT1A7
25	Steroid hormone biosynthesis²⁰	7.3	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6
26	Metabolism of xenobiotics by cytochrome P450²⁰	7.3	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6
27	Drug metabolism - cytochrome P450²⁰	7.3	UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3
28	Retinol metabolism²⁰	7.2	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6
29	Pentose and glucuronate interconversions²⁰	7.2	UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3
30	Starch and sucrose metabolism²⁰	7.2	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6
31	Drug metabolism - other enzymes²⁰	7.2	UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7
32	Other types of O-glycan biosynthesis²⁰	7.2	UGT2B28, UGT2A3, UGT1A1, UGT1A10, UGT1A3, UGT1A4
33	Metabolic pathways²⁰	7.0	G6PD, UGT2B28, UGT2A3, UGT2A1, UGT1A9, UGT1A8

Compounds for genes affiliated with Kernicterus

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³²Novoseek , ³⁴PharmGKB, ⁹DrugBank, ¹⁸HMDB, ⁴²Tocris Bioscience
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Compounds related to kernicterus according to GeneDecks:

(show top 50) (show all 73)

id	Compound	Score	Top Affiliating Genes
1	n-acetylbenzidine³²	10.0	UGT1A1, UGT1A4, UGT1A9
2	flurbiprofen³² ³⁴ ⁹ ⁹	12.8	ALB, UGT1A9, UGT1A3, UGT1A1
3	sn38 glucuronide³²	9.7	UGT1A1, UGT1A7, UGT1A9
4	etodolac³² ⁹ ⁹	11.7	ALB, UGT1A9, UGT1A3, UGT1A10
5	acetaminophen glucuronide³² ¹⁸	10.7	UGT1A9, UGT1A6, UGT1A1
6	lamotrigine³² ⁹ ⁹	11.6	UGT1A6, UGT1A4, UGT1A3, UGT1A1
7	1-naphthol³²	9.5	UGT1A9, UGT1A6, UGT1A1
8	benzidine³²	9.5	UGT1A1, UGT1A4, UGT1A6, UGT1A9
9	4-methylumbelliferone³²	9.5	UGT1A9, UGT1A6, UGT1A1
10	udp glucuronic acid³²	9.5	UGT1A8, UGT1A6, UGT1A10, UGT1A1
11	mycophenolate mofetil³² ⁹ ⁹	11.4	UGT1A1, UGT1A10, UGT1A8, UGT1A9, ALB
12	trifluoperazine³² ⁹ ⁹	11.4	UGT1A9, UGT1A6, UGT1A4, UGT1A1
13	phenol³² ¹⁸	10.4	G6PD, UGT1A9, UGT1A6, UGT1A1
14	p-nitrophenol³² ⁹ ⁹	11.3	UGT1A9, UGT1A6, UGT1A4, UGT1A3, UGT1A1
15	ibuprofen³² ⁹ ¹⁸ ⁹	12.3	ABCC1, ALB, UGT1A9, UGT1A3, UGT1A1
16	sn 38³² ⁴²	10.2	UGT1A1, UGT1A7, UGT1A9, ABCC1
17	mycophenolic acid³² ⁹ ⁹	11.1	ALB, UGT1A9, UGT1A8, UGT1A7, UGT1A10, UGT1A1
18	uridine³² ⁹ ¹⁸ ⁹	12.0	UGT1A1, UGT1A4, UGT1A6, UGT1A7, UGT1A9
19	flavopiridol³² ⁹ ⁹	11.0	UGT1A1, UGT1A7, UGT1A9, ABCC1
20	acetaminophen³² ³⁴ ⁹ ¹⁸ ⁹	13.0	G6PD, UGT1A9, UGT1A7, UGT1A6, UGT1A4, UGT1A1
21	morphine³² ⁹ ⁹	10.9	UGT1A9, UGT1A8, UGT1A6, UGT1A4, UGT1A3, UGT1A1
22	irinotecan³² ³⁴ ⁹ ⁹	11.8	UGT1A1, UGT1A6, UGT1A7, UGT1A9, ABCC1
23	quercetin³² ⁴² ⁹ ¹⁸ ⁹	12.8	ABCC1, UGT3A1, UGT1A9, UGT1A3, UGT1A1
24	tamoxifen³² ³⁴ ⁹ ⁹	11.7	G6PD, UGT1A9, UGT1A6, UGT1A4, UGT1A3, UGT1A1
25	benzo(a)pyrene³²	8.7	UGT1A9, UGT1A7, UGT1A6, UGT1A1
26	troglitazone³² ⁴² ⁹ ⁹	11.6	UGT1A9, UGT1A8, UGT1A6, UGT1A4, UGT1A3, UGT1A10
27	uridine diphosphate³²	8.6	UGT1A9, UGT1A7, UGT1A6, UGT1A4, UGT1A3, UGT1A10
28	diclofenac³² ³⁴ ⁹ ⁹	11.6	ABCC1, ALB, UGT1A9, UGT1A6, UGT1A4, UGT1A3
29	n-hydroxy phip³²	8.6	UGT1A9, UGT1A8, UGT1A7, UGT1A6, UGT1A4, UGT1A10
30	valproic acid³² ³⁴ ⁹ ¹⁸ ⁹	12.5	ALB, UGT1A9, UGT1A8, UGT1A7, UGT1A6, UGT1A10
31	propofol³² ⁹ ⁹	10.5	UGT1A1, UGT1A10, UGT1A3, ALB, UGT1A9, UGT1A8
32	ethyl glucuronide³² ¹⁸	9.3	UGT1A10, UGT1A1, UGT1A3, UGT1A4, UGT1A9, UGT1A8
33	cotinine³² ¹⁸	9.3	UGT1A9, UGT1A8, UGT1A7, UGT1A6, UGT1A4, UGT1A3
34	imipramine³² ³⁴ ⁹ ¹⁸ ⁹	12.3	UGT1A9, UGT1A8, UGT1A7, UGT1A6, UGT1A4, UGT1A3
35	nicotine³² ³⁴ ⁹ ⁹	11.2	UGT1A9, UGT1A8, UGT1A7, UGT1A6, UGT1A4, UGT1A3
36	glucuronide³²	8.1	ABCC1, UGT1A9, UGT1A7, UGT1A6, UGT1A4, UGT1A3
37	sn-38³⁴	8.1	UGT1A9, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A4
38	(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)¹⁸	7.3	UGT2A3, UGT2A1, UGT1A9, UGT1A8, UGT1A7, UGT1A6
39	Estriol⁹ ¹⁸ ⁹	9.3	UGT2A1, UGT1A9, UGT1A8, UGT1A7, UGT1A6, UGT1A5
40	etiocholanolone³² ¹⁸	8.3	UGT2B28, UGT2A3, UGT2A1, UGT1A9, UGT1A8, UGT1A7
41	androsterone glucuronide³² ¹⁸	8.3	UGT1A9, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A4
42	3-alpha-androstanediol glucuronide³² ¹⁸	8.3	UGT2B28, UGT2A3, UGT2A1, UGT1A9, UGT1A8, UGT1A7
43	aldosterone 18-glucuronide³² ¹⁸	8.3	UGT1A9, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A4
44	bilirubin diglucuronide³² ¹⁸	8.3	UGT1A9, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A4
45	codeine³² ³⁴ ⁹ ¹⁸ ⁹	11.3	UGT2B28, UGT2A3, UGT2A1, UGT1A9, UGT1A8, UGT1A7
46	2-methoxyestradiol³² ¹⁸	8.3	UGT1A7, UGT1A6, UGT1A5, UGT1A4, UGT1A3, UGT1A10
47	retinoic acid³² ⁴² ¹⁸	9.2	UGT2B28, UGT2A3, UGT2A1, UGT1A9, UGT1A8, UGT1A7
48	estrone³² ⁹ ¹⁸ ⁹	10.1	UGT1A9, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A4
49	estradiol³² ⁹ ¹⁸ ⁹	10.1	ALB, UGT2B28, UGT2A3, UGT2A1, UGT1A9, UGT1A8
50	testosterone³² ⁹ ¹⁸ ⁹	9.9	UGT2A3, UGT2A1, UGT1A9, UGT1A8, UGT1A7, UGT1A6

GO Terms for genes affiliated with Kernicterus

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¹²Gene Ontology
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Cellular components related to kernicterus according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intracellular membrane-bounded organelle	GO:043231	8.9	UGT1A5, UGT1A6, UGT1A8, UGT1A9, G6PD
2	endoplasmic reticulum membrane	GO:005789	7.3	UGT1A1, UGT2B28, UGT1A9, UGT1A8, UGT1A7, UGT1A6
3	integral to membrane	GO:016021	6.0	UGT2A1, UGT2A3, UGT2B28, UGT3A1, UGT3A2, SLC35A2

Biological processes related to kernicterus according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	coumarin metabolic process	GO:009804	9.7	UGT1A7, UGT1A8
2	negative regulation of steroid metabolic process	GO:045939	9.6	UGT1A1, UGT1A8
3	cellular glucuronidation	GO:052695	9.5	UGT2A3, UGT2A1, UGT1A10
4	negative regulation of fatty acid metabolic process	GO:045922	9.4	UGT1A9, UGT1A8, UGT1A7
5	negative regulation of catalytic activity	GO:043086	9.3	UGT1A1, UGT1A7, UGT1A8, UGT1A9
6	drug metabolic process	GO:017144	9.2	UGT1A1, UGT1A7, UGT1A8, UGT1A9
7	flavonoid glucuronidation	GO:052696	9.1	UGT1A9, UGT1A8, UGT1A7, UGT1A3, UGT1A1
8	xenobiotic glucuronidation	GO:052697	9.1	UGT1A1, UGT1A3, UGT1A7, UGT1A8, UGT1A9
9	flavone metabolic process	GO:051552	9.1	UGT1A9, UGT1A8, UGT1A7, UGT1A10, UGT1A1
10	retinoic acid metabolic process	GO:042573	9.1	UGT1A9, UGT1A8, UGT1A7, UGT1A3, UGT1A1
11	xenobiotic metabolic process	GO:006805	8.9	UGT2B28, UGT1A9, UGT1A6, UGT1A5, UGT1A4, UGT1A1
12	metabolic process	GO:008152	8.6	UGT1A10, UGT2B28, UGT2A1, UGT1A9, UGT1A6, UGT1A5

Molecular functions related to kernicterus according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	drug binding	GO:008144	9.5	UGT1A7, UGT1A8, ALB
2	enzyme inhibitor activity	GO:004857	8.9	UGT1A9, UGT1A8, UGT1A7, UGT1A1
3	retinoic acid binding	GO:001972	8.0	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A7
4	enzyme binding	GO:019899	7.9	UGT1A9, UGT1A8, UGT1A7, UGT1A6, UGT1A4, UGT1A3
5	protein heterodimerization activity	GO:046982	7.9	UGT1A9, UGT1A8, UGT1A7, UGT1A6, UGT1A4, UGT1A3
6	protein homodimerization activity	GO:042803	7.6	G6PD, UGT1A9, UGT1A8, UGT1A7, UGT1A6, UGT1A4
7	glucuronosyltransferase activity	GO:015020	6.5	UGT1A1, UGT3A2, UGT3A1, UGT2B28, UGT2A3, UGT1A10