MCID: KRN004
MIFTS: 53

Kernicterus malady

Rare diseases, Fetal diseases, Neuronal diseases, Infectious diseases categories

Summaries for Kernicterus

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Wikipedia:65 Kernicterus is a bilirubin-induced brain dysfunction. Bilirubin is a highly neurotoxic substance that... more...

MalaCards based summary: Kernicterus, also known as bilirubin encephalopathy, is related to neonatal jaundice and glucose-6-phosphate dehydrogenase deficiency. An important gene associated with Kernicterus is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Nicotine Pathway, Pharmacokinetics and Transport of vitamins, nucleosides, and related molecules. The compounds Deoxycholic acid 3-glucuronide and Etiocholanolone glucuronide have been mentioned in the context of this disorder. Affiliated tissues include brain, globus pallidus and liver.

Aliases & Classifications for Kernicterus

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Kernicterus, Aliases & Descriptions:

Name: Kernicterus 10 43 12 45 49 4 62
Bilirubin Encephalopathy 10 43 49 62
Hyperbilirubinemic Encephalopathy 43 62
Kernicterus of Newborn 10 62
 
Small Pox 43 49
Variola 43 49
Kernicterus of Newborn Nos 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases, Infectious diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology10 DOID:2382
MeSH35 D007647
NCIt40 C84799
Orphanet49 415675, 415286
ICD1027 P57

Related Diseases for Kernicterus

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Diseases in the Kernicterus family:

Kernicterus Due to Isoimmunization

Diseases related to Kernicterus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1neonatal jaundice30.8UGT1A1, G6PD, RHD
2glucose-6-phosphate dehydrogenase deficiency30.7UGT1A1, G6PD
3blood group incompatibility30.4G6PD
4crigler-najjar syndrome, type ii30.4UGT1A1, UGT1A4
5crigler-najjar syndrome, type i30.0UGT1A1, UGT1A4
6hereditary spherocytosis29.9UGT1A1, SLC4A1, G6PD, RHD
7hemolytic anemia29.9G6PD, SLC4A1, RHD, UGT1A1
8variola minor11.0
9variola major10.9
10smallpox10.8
11monkeypox10.7
12vaccinia10.6
13kernicterus due to isoimmunization10.5
14cowpox10.5
15brain injury10.2
16cerebritis10.2
17hepatitis10.1
18neuronitis10.1
19leprosy10.1
20tuberculoid leprosy10.1
21gilbert syndrome10.1UGT1A1
22hereditary elliptocytosis10.0SLC4A1
23thalassemias, alpha-10.0UGT1A1, G6PD
24venezuelan equine encephalitis10.0
25encephalitis10.0
26cholelithiasis10.0UGT1A1, UGT1A6
27autoimmune hepatitis10.0UGT1A9, UGT1A1
28acute kidney failure10.0ALB, G6PD
29leukopenia10.0UGT1A1, ALB
30autoimmune hemolytic anemia10.0G6PD, RHCE
31galactosemia10.0ALB, UGT1A1
32thalassemia10.0SLC4A1, UGT1A1, G6PD
33diarrhea10.0ALB, UGT1A1, UGT1A6
34hepatitis c10.0ALB, UGT1A9, UGT1A7
35bilirubin metabolic disorder10.0ALB, UGT1A7, UGT1A1, G6PD
36thalassemia, hispanic gamma-delta-beta10.0G6PD, RHD, UGT1A1
37hepatocellular carcinoma10.0ALB, UGT1A1, UGT1A9, UGT1A7
38sickle cell disease10.0UGT1A1, G6PD, RHD
39congenital dyserythropoietic anemia10.0RHD, SLC4A1
40hyperhomocysteinemia10.0ALB, RHD
41metabolic acidosis10.0SLC4A1, ALB
42rh isoimmunization10.0RHCE, RHD
43colorectal cancer10.0UGT1A1, UGT1A6, UGT1A9, UGT1A7
44liver cirrhosis10.0UGT1A7, RHD, ALB
45hepatitis b10.0ALB, RHD, UGT1A7
46hyperbilirubinemia, familial transient neonatal10.0
47cerebral palsy10.0
48rheumatic fever10.0
49central pontine myelinolysis10.0
50congenital hypothyroidism10.0

Graphical network of the top 20 diseases related to Kernicterus:



Diseases related to kernicterus

Symptoms for Kernicterus

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Drugs & Therapeutics for Kernicterus

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Drug clinical trials:

Search ClinicalTrials for Kernicterus

Search NIH Clinical Center for Kernicterus

Genetic Tests for Kernicterus

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Anatomical Context for Kernicterus

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MalaCards organs/tissues related to Kernicterus:

33
Brain, Globus pallidus, Liver, Breast, Endothelial

Animal Models for Kernicterus or affiliated genes

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Publications for Kernicterus

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Articles related to Kernicterus:

(show top 50)    (show all 338)
idTitleAuthorsYear
1
Serum unbound bilirubin as a predictor for clinical kernicterus in extremely low birth weight infants at a late age in the neonatal intensive care unit. (25638486)
2015
2
Jaundice and kernicterus in the moderately preterm infant. (24182955)
2013
3
The Italian Registry of kernicterus and hyperbilirubinaemia. (22958040)
2012
4
Fatal kernicterus in a girl deficient in glucose-6-phosphate dehydrogenase: a paradigm of synergistic heterozygosity. (19324225)
2009
5
Unbound bilirubin: a better predictor of kernicterus? (18160727)
2008
6
Kernicterus in an adult dog. (17491082)
2007
7
Kernicterus associated with hereditary spherocytosis and UGT1A1 promoter polymorphism. (16735790)
2006
8
Magnetic resonance imaging of the brain in children with chronic kernicterus. (22266622)
2006
9
Hyperintense globus pallidus on T1-weighted MR imaging in acute kernicterus: is it common or rare? (15565320)
2005
10
Understanding severe hyperbilirubinemia and preventing kernicterus: adjuncts in the interpretation of neonatal serum bilirubin. (15936300)
2005
11
Urgent clinical need for accurate and precise bilirubin measurements in the United States to prevent kernicterus. (14726464)
2004
12
Research on prevention of bilirubin-induced brain injury and kernicterus: National Institute of Child Health and Human Development conference executive summary. 2003. (15231933)
2004
13
Cost-effectiveness of strategies that are intended to prevent kernicterus in newborn infants. (15466085)
2004
14
Kernicterus and G6PD deficiency--a case series from Oman. (12729287)
2003
15
Breast-feeding, neonatal jaundice and kernicterus. (12208098)
2002
16
System-based approach to management of neonatal jaundice and prevention of kernicterus. (12006952)
2002
17
Preterm infants with athetoid cerebral palsy: kernicterus? (11207234)
2001
18
From the Centers for Disease Control and Prevention. Kernicterus in full-term infants--United States, 1994-1998. (11474907)
2001
19
Risk factors for kernicterus in term babies with non-hemolytic jaundice. (11463962)
2001
20
Kernicterus threatens healthy newborns. (11424865)
2001
21
Kernicterus in a full-term infant: the need for increased vigilance. (7724333)
1995
22
Kernicterus in preterm infants; lest we forget (to turn on the lights) (1408550)
1992
23
Assessing the risk of kernicterus using nuclear magnetic resonance. (2369802)
1990
24
Auditory brainstem response in patients with a history of kernicterus. (3272525)
1988
25
Kernicterus in the premature neonate. (3333255)
1987
26
Neonatal bilirubin toxicity. A review of kernicterus and the implications of drug-induced bilirubin displacement. (3304769)
1987
27
Value and limitations of bilirubin binding capacity in predicting the development of kernicterus. (6466218)
1984
28
Kernicterus at low levels of serum bilirubin: the impact of bilirubin albumin-binding capacity. A 10-year retrospective survey. (7199940)
1982
29
Kernicterus: effect on choline acetyltransferase, glutamic acid decarboxylase and tyrosine hydroxylase activities in the brain of the Gunn rat. (6105009)
1980
30
Singapore kernicterus. (262490)
1979
31
The pathochemistry of kernicterus. (43803)
1979
32
Absence of kernicterus in low-birth weight infants from 1971 through 1976: comparison with findings in 1966 and 1967. (714577)
1978
33
Breakdown of blood/brain barrier in kernicterus. (67529)
1977
34
An electron microscopic and radioautographic study on experimental kernicterus. I. Bilirubin transport via astroglia. (5815579)
1969
35
Serum albumin reserve PSP dye binding capacity in infants with kernicterus. (6067403)
1967
36
Risk of kernicterus in newborn infants with a high level of conjugated bilirubin. (6007580)
1966
37
KERNICTERUS IN NEWBORN RABBITS. (14266216)
1965
38
PREVENTION OF CEREBRAL DAMAGE (KERNICTERUS) FROM FOETO-MATERNAL INCOMPATIBILITY; ANTENATAL ASPECTS. (14062989)
1963
39
Kernicterus in premature infants associated with low concentrations of bilirubin in the plasma. (13553575)
1958
40
Clinical kernicterus and congenital hypothyroidism. (13493800)
1958
41
Congenital hemolytic anemia in the newborn; relationship to kernicterus. (13478296)
1957
42
Experimental studies on the pathogenesis of kernicterus. (13484304)
1957
43
Congenital cirrhosis of the liver with kernicterus; report of two cases in siblings with a discussion of the relationship to so-called neonatal hepatitis and to iso-immunization disease. (13268609)
1955
44
Prevention of death and crippling from kernicterus in hemolytic disease of the newborn. (13221977)
1954
45
Cerebrospinal fluid bilirubin in the neonatal period with special reference to the development of kernicterus; preliminary report. (13217811)
1954
46
The mechanism of production of kernicterus. (13000553)
1952
47
Kernicterus. (14819084)
1951
48
Central nervous system complications associated with kernicterus. (21011225)
1946
49
Pathogenesis of Kernicterus. (17800122)
1946
50
Case of Kernicterus. (19992043)
1939

Variations for Kernicterus

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Expression for genes affiliated with Kernicterus

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Search GEO for disease gene expression data for Kernicterus.

Pathways for genes affiliated with Kernicterus

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Pathways related to Kernicterus according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Nicotine metabolism38
9.8UGT1A9, UGT1A4
2
Show member pathways
9.8SLC35A2, ALB
3
Show member pathways
bupropion degradation38
methylglyoxal degradation III38
nicotine degradation III38
nicotine degradation IV38
9.8UGT1A4, UGT1A10
4
Show member pathways
AhR pathway38
9.8UGT1A1, UGT1A6
5
Show member pathways
Codeine and morphine metabolism38
9.7UGT1A1, UGT1A8
69.6UGT1A10, UGT1A8
7
Show member pathways
9.6UGT1A10, UGT1A9, UGT1A1
89.5UGT1A9, UGT1A6, UGT1A1
9
Show member pathways
8.6UGT1A4, UGT1A9, UGT1A6, UGT1A8, UGT1A1
108.6UGT1A4, UGT1A9, UGT1A6, UGT1A8, UGT1A1
118.5UGT1A4, UGT1A10, UGT1A9, UGT1A6, UGT1A8
12
Show member pathways
7.9UGT1A7, UGT1A1, UGT1A8, UGT1A6, UGT1A9, UGT1A10
13
Show member pathways
7.6UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A5, UGT1A6
14
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism38
7.6UGT1A1, UGT1A8, UGT1A7, UGT1A4, UGT1A10, UGT1A9
15
Show member pathways
7.6UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A5, UGT1A6
16
Show member pathways
7.6UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A5, UGT1A6
17
Show member pathways
7.6UGT1A10, UGT1A4, UGT1A7, UGT1A9, UGT1A5, UGT1A6
18
Show member pathways
tetrapyrrole biosynthesis38
heme degradation38
Heme Biosynthesis38
heme biosynthesis38
heme biosynthesis from uroporphyrinogen-III I38
7.6UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
19
Show member pathways
6.6UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A5, UGT1A6

Compounds for genes affiliated with Kernicterus

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Compounds related to Kernicterus according to GeneCards/GeneDecks:

(show top 50)    (show all 167)
idCompoundScoreTop Affiliating Genes
1Deoxycholic acid 3-glucuronide268.1UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A4, UGT1A7
2Etiocholanolone glucuronide268.1UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
3Glycochenodeoxycholic acid 3-glucuronide268.1UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
4Dextrorphan O-glucuronide268.1UGT1A7, UGT1A4, UGT1A10, UGT1A1, UGT1A8, UGT1A6
5Isovalerylglucuronide268.1UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A4
6Ketoprofen glucuronide268.1UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
7Inodxyl glucuronide268.1UGT1A7, UGT1A4, UGT1A1, UGT1A8, UGT1A6, UGT1A5
8Cholesterol glucuronide268.1UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
9Cholic acid glucuronide268.1UGT1A4, UGT1A7, UGT1A10, UGT1A9, UGT1A5, UGT1A1
10Cortolone-3-glucuronide268.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
11Cotinineglucuronide268.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
12Dehydroepiandrosterone 3-glucuronide268.0UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A1, UGT1A8
13Dehydroisoandrosterone 3-glucuronide268.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
14trans-3-Hydroxycotinine glucuronide268.0UGT1A4, UGT1A7, UGT1A1, UGT1A8, UGT1A6, UGT1A5
15Tyramine glucuronide268.0UGT1A9, UGT1A10, UGT1A4, UGT1A7, UGT1A5, UGT1A6
16Uridine 5'-diphosphate268.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
17Triiodothyronine glucuronide268.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
18Valproic acid glucuronide268.0UGT1A10, UGT1A4, UGT1A7, UGT1A9, UGT1A5, UGT1A6
19Vitamin D2 3-glucuronide268.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
20Uridine diphosphate glucuronic acid268.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
21Nicotine glucuronide268.0UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A4, UGT1A7
22Octanoylglucuronide268.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
23Lithocholate 3-O-glucuronide268.0UGT1A7, UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9
24Thyroxine glucuronide268.0UGT1A5, UGT1A9, UGT1A10, UGT1A4, UGT1A7, UGT1A6
25Tetrahydroaldosterone-3-glucuronide268.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
261-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid268.0UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A4, UGT1A7
2711-beta-hydroxyandrosterone-3-glucuronide268.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
2811-Hydroxyprogesterone 11-glucuronide268.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
291-Salicylate glucuronide268.0UGT1A7, UGT1A4, UGT1A10, UGT1A1, UGT1A8, UGT1A6
3015-hydroxynorandrostene-3,17-dione glucuronide268.0UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A4
3116-alpha,17-beta-estriol 17-beta-D-glucuronide268.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
3211-Oxo-androsterone glucuronide267.9UGT1A7, UGT1A4, UGT1A1, UGT1A8, UGT1A6, UGT1A5
33codeine45 30 51 26 1311.9UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
342-methoxyestradiol45 61 269.9UGT1A4, UGT1A7, UGT1A10, UGT1A9, UGT1A5, UGT1A1
35androsterone glucuronide45 268.9UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
36etiocholanolone45 268.9UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
37aldosterone 18-glucuronide45 268.9UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A1, UGT1A8
38(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)267.9UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
393-alpha,20-alpha-dihydroxy-5-beta-pregnane 3-glucuronide267.9UGT1A4, UGT1A7, UGT1A1, UGT1A8, UGT1A6, UGT1A5
403-Methoxy-4-hydroxyphenylglycol glucuronide267.9UGT1A9, UGT1A10, UGT1A4, UGT1A7, UGT1A5, UGT1A6
414-Hydroxyandrostenedione glucuronide267.8UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
423-alpha-hydroxy-5-alpha-androstane-17-one 3-D-glucuronide267.8UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
435-Hydroxy-6-methoxyindole glucuronide267.8UGT1A10, UGT1A4, UGT1A7, UGT1A9, UGT1A5, UGT1A6
44Cholestane-3,7,12,25-tetrol-3-glucuronide267.8UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
455-alpha-Dihydrotestosterone glucuronide267.7UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
462-Phenylethanol glucuronide267.7UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A4, UGT1A7
4725-Hydroxyvitamin D2 25-(beta-glucuronide)267.6UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
4825-Hydroxyvitamin D2-25-glucuronide267.6UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
4917-alpha-estradiol-3-glucuronide267.5UGT1A7, UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9
503,17-Androstanediol glucuronide267.3UGT1A5, UGT1A9, UGT1A10, UGT1A4, UGT1A7, UGT1A6

GO Terms for genes affiliated with Kernicterus

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Cellular components related to Kernicterus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:00057897.3UGT1A1, UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A5
2integral component of membraneGO:00160216.9UGT1A4, UGT1A10, UGT1A9, UGT1A5, UGT1A6, UGT1A8

Biological processes related to Kernicterus according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1coumarin metabolic processGO:00098049.6UGT1A8, UGT1A7
2negative regulation of fatty acid metabolic processGO:00459229.4UGT1A8, UGT1A9, UGT1A7
3negative regulation of steroid metabolic processGO:00459399.4UGT1A1, UGT1A8
4negative regulation of cellular glucuronidationGO:020010309.3UGT1A7, UGT1A9, UGT1A8, UGT1A1
5xenobiotic glucuronidationGO:00526979.3UGT1A7, UGT1A9, UGT1A8, UGT1A1
6flavonoid glucuronidationGO:00526969.3UGT1A7, UGT1A9, UGT1A8, UGT1A1
7cellular glucuronidationGO:00526959.3UGT1A4, UGT1A10, UGT1A6, UGT1A1
8retinoic acid metabolic processGO:00425739.2UGT1A1, UGT1A8, UGT1A9, UGT1A7
9drug metabolic processGO:00171449.2UGT1A7, UGT1A9, UGT1A8, UGT1A1
10negative regulation of catalytic activityGO:00430869.1UGT1A7, UGT1A9, UGT1A8, UGT1A1
11flavone metabolic processGO:00515529.0UGT1A1, UGT1A8, UGT1A9, UGT1A10, UGT1A7
12xenobiotic metabolic processGO:00068059.0UGT1A4, UGT1A9, UGT1A6, UGT1A1
13small molecule metabolic processGO:00442818.1UGT1A4, UGT1A9, UGT1A6, UGT1A1, G6PD, ALB

Molecular functions related to Kernicterus according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1protein kinase C bindingGO:00050809.8UGT1A7, UGT1A10
2fatty acid bindingGO:00055049.6ALB, UGT1A8
3drug bindingGO:00081449.4UGT1A7, UGT1A8, ALB
4steroid bindingGO:00054969.4UGT1A8, UGT1A1
5enzyme inhibitor activityGO:00048579.2UGT1A1, UGT1A8, UGT1A9, UGT1A7
6ammonium transmembrane transporter activityGO:00085199.0RHCE, RHD
7retinoic acid bindingGO:00019728.1UGT1A1, UGT1A8, UGT1A6, UGT1A9, UGT1A10, UGT1A4
8protein heterodimerization activityGO:00469828.1UGT1A1, UGT1A8, UGT1A6, UGT1A9, UGT1A10, UGT1A4
9glucuronosyltransferase activityGO:00150207.8UGT1A10, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A4
10enzyme bindingGO:00198997.8UGT1A10, UGT1A6, UGT1A7, ALB, UGT1A1, UGT1A4
11protein homodimerization activityGO:00428037.3SLC4A1, UGT1A1, UGT1A8, UGT1A6, UGT1A9, UGT1A10

Products for genes affiliated with Kernicterus

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