MCID: KRN004
MIFTS: 46

Kernicterus malady

Categories: Rare diseases, Fetal diseases, Neuronal diseases, Metabolic diseases, Blood diseases, Cancer diseases, Skin diseases

Aliases & Classifications for Kernicterus

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Sources:
2CDC, 11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 39MeSH, 45NCIt, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Kernicterus:

Name: Kernicterus 11 48 54 50 2 39 13 68
Bilirubin Encephalopathy 11 48 54
 
Hyperbilirubinemic Encephalopathy 48

Characteristics:

Orphanet epidemiological data:

54
kernicterus:
Inheritance: Not applicable; Age of onset: Neonatal

Classifications:



External Ids:

Disease Ontology11 DOID:2382
ICD1030 P57, P57.9, P57.8
MeSH39 D007647
NCIt45 C84799
Orphanet54 ORPHA415286
ICD10 via Orphanet31 P57.9

Summaries for Kernicterus

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NIH Rare Diseases:48 Kernicterus is a rare condition that affects the brain. It refers to a form of brain damage that occurs when neonatal jaundice goes untreated for too long. The severity of the condition and the associated signs and symptoms vary significantly from person to person. People living with kernicterus may experience athetoid cerebral palsy, hearing loss, intellectual disability, vision abnormalities, and behavioral difficulties. Approximately 60% of all newborn babies will have jaundice, a condition that is characterized by high level of bilirubin in the blood. Risk factors for severe jaundice and higher bilirubin levels include premature birth (before 37 weeks); darker skin color; East Asian or Mediterranean descent; feeding difficulties; jaundice in a sibling; bruising at birth; and a mother with an O blood type or Rh negative blood factor. Early detection and management of jaundice can prevent kernicterus. Last updated: 3/16/2016

MalaCards based summary: Kernicterus, also known as bilirubin encephalopathy, is related to crigler-najjar syndrome, type ii and crigler-najjar syndrome, type i, and has symptoms including bulging fontanelle, neonatal dyskinesia and tremor, neonatal. An important gene associated with Kernicterus is UGT1A1 (UDP Glucuronosyltransferase Family 1 Member A1), and among its related pathways are Central carbon metabolism in cancer and Nicotine Pathway, Pharmacokinetics. Affiliated tissues include brain, globus pallidus and breast, and related mouse phenotype Decreased shRNA abundance (Z-score < -2).

Disease Ontology:11 A brain disease that is characterized by hyperbilirubinemia-induced brain dysfunction.

Wikipedia:71 Kernicterus is a bilirubin-induced brain dysfunction. Bilirubin is a highly neurotoxic substance that... more...

Related Diseases for Kernicterus

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Diseases in the Kernicterus family:

Kernicterus Due to Isoimmunization

Diseases related to Kernicterus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1crigler-najjar syndrome, type ii30.7UGT1A1, UGT1A4, UGT1A6, UGT1A9
2crigler-najjar syndrome, type i30.2UGT1A1, UGT1A4, UGT1A6, UGT1A9
3kernicterus due to isoimmunization12.1
4cerebral palsy athetoid10.9
5larynx sarcoma10.4G6PD, UGT1A1
6renal artery disease10.3G6PD, UGT1A1
7spastic paraplegia 3a10.2G6PD, UGT1A1
8neonatal jaundice10.2
9bronchial disease10.2ALB, UGT1A1
10serpiginous choroiditis10.2ALB, G6PD
11hemoglobin h disease, nondeletional10.2G6PD, UGT1A1
12articulation disorder10.2RHCE, SLC4A1
13encephalopathy10.1
14ulcerative stomatitis10.1ALB, G6PD
15conjunctival vascular disease10.0ALB, RHCE
16adenylosuccinase lyase deficiency10.0ALB, SLC4A1
17pseudohypoparathyroidism10.0ALB, RHCE
18superficial keratitis10.0UGT1A1, UGT1A6
19dihydropyrimidine dehydrogenase deficiency9.9UGT1A1, UGT1A6
20common wart9.9ALB, SLC4A1
21brain injury9.9
22cerebritis9.9
23blood group incompatibility9.9
24plasmodium vivax malaria9.8SLC4A1, UGT1A1
25hepatitis9.8
26neuronitis9.8
27pyruvate kinase deficiency9.8G6PD, PKM, SLC4A1
28thalassemia-beta, dominant inclusion-body9.7UGT1A1, UGT1A6
29posterior foramen magnum meningioma9.6UGT1A1, UGT1A6
30cerebral palsy9.6
31hemolytic anemia9.6
32congenital hypothyroidism9.6
33aphasia9.6
34hereditary spherocytosis9.6
35hypothyroidism9.6
36rheumatic fever9.6
37viral hepatitis9.6
38congenital hemolytic anemia9.6
39central pontine myelinolysis9.6
40athetosis9.6
41anoxia9.6
42endotheliitis9.6
43fulminant viral hepatitis9.6
44dermatomyositis9.5ALB, UGT1A1, UGT1A6
45acute hydrops keratoconus9.5PKM, UGT1A1, UGT1A6
46pyeloureteritis cystica9.0ALB, PKM, UGT1A1, UGT1A6
47auditory system disease9.0G6PD, UGT1A1, UGT1A4, UGT1A6, UGT1A9
48wernicke encephalopathy7.2ALB, G6PD, PKM, RHCE, SLC4A1, UGT1A1

Graphical network of the top 20 diseases related to Kernicterus:



Diseases related to kernicterus

Symptoms & Phenotypes for Kernicterus

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UMLS symptoms related to Kernicterus:


bulging fontanelle, neonatal dyskinesia, tremor, neonatal, yellow complexion, hepatocellular jaundice

GenomeRNAi Phenotypes related to Kernicterus according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-589.2RHCE, SLC4A1, UGT1A1

Drugs & Therapeutics for Kernicterus

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Drugs for Kernicterus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AntioxidantsPhase 42928
2AntibodiesPhase 46045
3Protective AgentsPhase 47190
4Rho(D) Immune GlobulinPhase 4317
5
BilirubinPhase 4112635-65-45280352
Synonyms:
(4Z,15Z)-Bilirubin IXa
(Z,Z)-Bilirubin IXa
1,10,19,22,23,24-Hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionate
1,10,19,22,23,24-Hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionic acid
2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8,12-dipropanoate
2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8,12-dipropanoic acid
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoate
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
 
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-[(Z)-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-1H-pyrrol-2-yl)methyl)-4-methyl-5-[(Z)-(4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene
3-[2-[[3-(2-Carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate
3-[2-[[3-(2-Carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
3-[2-[[3-(2-Carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate
3-[2-[[3-(2-Carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
Bilirubin
Bilirubin IX-alpha
Cholerythrin
Hematoidin
6Pharmaceutical SolutionsPhase 47793
7gamma-GlobulinsPhase 4317
8ImmunoglobulinsPhase 46045
9Immunoglobulins, IntravenousPhase 4324
10Tin mesoporphyrinPhase 314
11
TinPhase 3707440-31-5
Synonyms:
CI Pigment metal 5
Haro Mix ZT-514
Innohep
Metallic tin
SN
 
Silver matt powder
Stanum
Tin flake
Tin powder
Tindamax
ZINN
12
Mentholapproved23532216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol
13
Carbon monoxideapproved116630-08-0281
Synonyms:
CO
 
Carbon monoxide
Carboneum oxygenisatum
carbon(II) oxide
14Neurotransmitter Agents17734
15Antimetabolites11774

Interventional clinical trials:

(show all 12)
idNameStatusNCT IDPhase
1Use of a New Phototherapy Device (BBloo®) for the Treatment of Hyperbilirubinemia in the Newborn InfantUnknown statusNCT02156050Phase 4
2Efficacy of High-dose Intravenous Immunoglobulin Therapy for Hyperbilirubinemia Due Rh Hemolytic DiseaseCompletedNCT00288600Phase 4
3Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase DeficiencyRecruitingNCT02594904Phase 4
4Efficacy and Safety of Stannsoporfin in NeonatesCompletedNCT02685137Phase 3
5New Phototherapy Device to Treat Patients With Crigler-Najjar DiseaseUnknown statusNCT02356978
6Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment.Unknown statusNCT02224586
7Does Maternal Instruction Prevent Kernicterus in Nigeria?CompletedNCT02713464
8Determining Prevalence of Acute Bilirubin Encephalopathy in Developing CountriesCompletedNCT01754688
9Follow-up of Extreme Neonatal Hyperbilirubinemia in 5-10 Year Old Children: a Danish Population Based StudyCompletedNCT01599611
10Implementation of a Transcutaneous BilirubinometerCompletedNCT01622699
11Bilirubin Binding Capacity to Assess Bilirubin Load in Preterm InfantsRecruitingNCT02691156
12Clinical and Developmental Outcomes of Babies Who Became Yellow in the First Month of LifeNot yet recruitingNCT02927093

Search NIH Clinical Center for Kernicterus


Cochrane evidence based reviews: kernicterus

Genetic Tests for Kernicterus

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Anatomical Context for Kernicterus

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MalaCards organs/tissues related to Kernicterus:

36
Brain, Globus pallidus, Breast, Liver, Endothelial

Publications for Kernicterus

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Articles related to Kernicterus:

(show top 50)    (show all 346)
idTitleAuthorsYear
1
Kernicterus in Neonatal Jaundice-Finding the Needle in the Haystack. (26945202)
2016
2
A new rat model of neonatal bilirubin encephalopathy (kernicterus). (27746217)
2016
3
Chronic kernicterus: magnetic resonance imaging findings. (28057969)
2016
4
Glucose-6-Phosphate Dehydrogenase Deficiency and the Need for a Novel Treatment to Prevent Kernicterus. (27235212)
2016
5
Brain magnetic resonance imaging and magnetic resonance spectroscopy findings of children with kernicterus. (25745520)
2015
6
Serum unbound bilirubin as a predictor for clinical kernicterus in extremely low birth weight infants at a late age in the neonatal intensive care unit. (25638486)
2015
7
Current incidence of clinical kernicterus in preterm infants in Japan. (26113317)
2015
8
The Blockade of NF-I_B Activation by a Specific Inhibitory Peptide has a Strong Neuroprotective Role in a Sprague-Dawley Rat Kernicterus Model. (26499797)
2015
9
Why is kernicterus still a major cause of death and disability in low-income and middle-income countries? (25123403)
2014
10
The enigma of low bilirubin kernicterus in premature infants: Why does it still occur, and is it preventable? (25267279)
2014
11
What causes increased expression of VEGF and VEGF-R in a case report? Comment on: "New autopsy findings in different brain regions of a preterm neonate with kernicterus: neurovascular alterations and up-regulation of efflux transporters". (24739376)
2014
12
A novel newborn rat kernicterus model created by injecting a bilirubin solution into the cisterna magna. (24796550)
2014
13
Prevention of Kernicterus in South Asia: role of neonatal G6PD deficiency and its identification. (24763814)
2014
14
Jaundice and kernicterus in the moderately preterm infant. (24182955)
2013
15
MRI findings in kernicterus. (22990632)
2013
16
Cotrimoxazole and neonatal kernicterus: a review. (24099411)
2013
17
New autopsy findings in different brain regions of a preterm neonate with kernicterus: neurovascular alterations and up-regulation of efflux transporters. (24138949)
2013
18
Low bilirubin kernicterus with sepsis and hypoalbuminaemia. (23616313)
2013
19
Neonatal death suspected to be from sepsis was found to be kernicterus with G6PD deficiency. (24218468)
2013
20
Use of the extended parallel processing model to evaluate culturally relevant kernicterus messages. (23237614)
2013
21
Acute kernicterus in a neonate with O/B blood group incompatibility and a mutation in SLC4A1. (23878048)
2013
22
MRI findings in a dog with kernicterus. (23690488)
2013
23
The Italian Registry of kernicterus and hyperbilirubinaemia. (22958040)
2012
24
Medical education content required for kernicterus risk recognition. (23056881)
2012
25
Cerebellar axon/myelin loss, angiogenic sprouting, and neuronal increase of vascular endothelial growth factor in a preterm infant with kernicterus. (22190497)
2012
26
Cost-effectiveness analysis of a system-based approach for managing neonatal jaundice and preventing kernicterus in Ontario. (23277747)
2012
27
Birth-related syndromes of athetosis and kernicterus. (21496597)
2011
28
Are recommended phototherapy thresholds safe enough for extremely low birth weight (ELBW) infants? A report on 2 ELBW infants with kernicterus despite only moderate hyperbilirubinemia. (20639681)
2011
29
Prevention of acute bilirubin encephalopathy and kernicterus in newborns: position statement #3049. (22123452)
2011
30
Severe neonatal hyperbilirubinemia and kernicterus: are these still problems in the third millennium? (21968213)
2011
31
Evidence suggests there was not a "resurgence" of kernicterus in the 1990s. (21444599)
2011
32
Evaluation of oxidant and antioxidant status in infants with hyperbilirubinemia and kernicterus. (21393350)
2011
33
Prevention of acute bilirubin encephalopathy and kernicterus in newborns. Position Statement #3049. NANN Board of Directors, March 2010. (20505419)
2010
34
A proposal to prevent severe neonatal hyperbilirubinemia and kernicterus. (19177062)
2009
35
Synopsis report from the pilot USA Kernicterus Registry. (19177058)
2009
36
Clinical report from the pilot USA Kernicterus Registry (1992 to 2004). (19177057)
2009
37
Kernicterus in preterm infants. (19433515)
2009
38
Neonatal hyperbilirubinemia and kernicterus - not gone but sometimes forgotten. (19833460)
2009
39
Fatal kernicterus in a girl deficient in glucose-6-phosphate dehydrogenase: a paradigm of synergistic heterozygosity. (19324225)
2009
40
Trends in hospitalizations for neonatal jaundice and kernicterus in the United States, 1988-2005. (19171618)
2009
41
Changes in the globus pallidus in chronic kernicterus. (21887193)
2009
42
Kernicterus in the 21st century: frequently asked questions. (19177056)
2009
43
Obstetric outcome in Danish children with a validated diagnosis of kernicterus. (19639464)
2009
44
Severe hyperbilirubinaemia and kernicterus: more caution is needed in newborn jaundice surveillance. (19772008)
2009
45
Magnetic resonance imaging of bilateral mesial temporal sclerosis in chronic kernicterus. (21887194)
2009
46
Unbound bilirubin: a better predictor of kernicterus? (18160727)
2008
47
A new animal model of hemolytic hyperbilirubinemia-induced bilirubin encephalopathy (kernicterus). (18458656)
2008
48
Prevention of kernicterus: new guidelines and the critical role of family physicians. (18411389)
2008
49
Israel guidelines for the management of neonatal hyperbilirubinemia and prevention of kernicterus. (18322551)
2008
50
Kernicterus by glucose-6-phosphate dehydrogenase deficiency: a case report and review of the literature. (18460213)
2008

Variations for Kernicterus

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Expression for genes affiliated with Kernicterus

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Search GEO for disease gene expression data for Kernicterus.

Pathways for genes affiliated with Kernicterus

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Pathways related to Kernicterus according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.5G6PD, PKM
2
Show member pathways
9.5UGT1A4, UGT1A9
38.7UGT1A4, UGT1A6, UGT1A9
4
Show member pathways
8.4UGT1A1, UGT1A4, UGT1A6, UGT1A9
5
Show member pathways
8.4UGT1A1, UGT1A4, UGT1A6, UGT1A9
6
Show member pathways
8.4UGT1A1, UGT1A4, UGT1A6, UGT1A9
7
Show member pathways
8.4UGT1A1, UGT1A4, UGT1A6, UGT1A9
87.4G6PD, PKM, UGT1A1, UGT1A4, UGT1A6, UGT1A9
9
Show member pathways
6.6ALB, G6PD, PKM, SLC4A1, UGT1A1, UGT1A4

GO Terms for genes affiliated with Kernicterus

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Cellular components related to Kernicterus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:00057899.1UGT1A1, UGT1A4, UGT1A6, UGT1A9
2endoplasmic reticulumGO:00057838.8ALB, UGT1A1, UGT1A4, UGT1A6, UGT1A9
3extracellular exosomeGO:00700627.4ALB, G6PD, PKM, SLC4A1, UGT1A6, UGT1A9

Biological processes related to Kernicterus according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1bilirubin conjugationGO:000678910.3UGT1A1, UGT1A4
2heme catabolic processGO:004216710.3UGT1A1, UGT1A4
3flavone metabolic processGO:005155210.2UGT1A1, UGT1A9
4retinoic acid metabolic processGO:004257310.1UGT1A1, UGT1A9
5animal organ regenerationGO:003110010.1PKM, UGT1A1
6response to nutrientGO:00075849.7ALB, PKM, UGT1A1
7flavonoid biosynthetic processGO:00098139.5UGT1A1, UGT1A4, UGT1A6
8xenobiotic metabolic processGO:00068059.1UGT1A6, UGT1A9
9cellular glucuronidationGO:00526959.0UGT1A1, UGT1A4, UGT1A6, UGT1A9
10flavonoid glucuronidationGO:00526968.9UGT1A1, UGT1A4, UGT1A6, UGT1A9
11xenobiotic glucuronidationGO:00526978.9UGT1A1, UGT1A4, UGT1A6, UGT1A9

Molecular functions related to Kernicterus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:001989910.1ALB, SLC4A1, UGT1A1
2glucuronosyltransferase activityGO:00150209.1UGT1A1, UGT1A4, UGT1A6, UGT1A9
3protein heterodimerization activityGO:00469829.0UGT1A1, UGT1A4, UGT1A6, UGT1A9
4retinoic acid bindingGO:00019728.4UGT1A1, UGT1A4, UGT1A6, UGT1A9
5protein homodimerization activityGO:00428038.0G6PD, SLC4A1, UGT1A1, UGT1A4, UGT1A6, UGT1A9

Sources for Kernicterus

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
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57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet