MCID: KRN004
MIFTS: 47

Kernicterus malady

Summaries for Kernicterus

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63Wikipedia, 32MalaCards
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Wikipedia:63 Kernicterus is a bilirubin-induced brain dysfunction. Bilirubin is a highly neurotoxic substance that... more...

MalaCards: Kernicterus, also known as bilirubin encephalopathy, is related to neonatal jaundice and crigler-najjar syndrome. An important gene associated with Kernicterus is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Ifosfamide Pathway, Pharmacokinetics and Arylamine metabolism. The compounds n-acetylbenzidine and sn38 glucuronide have been mentioned in the context of this disorder. Affiliated tissues include brain, globus pallidus and liver.

Aliases & Classifications for Kernicterus

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

kernicterus 8 42 10 44 60
bilirubin encephalopathy 8 42
hyperbilirubinemic encephalopathy 42
kernicterus of newborn nos 8
kernicterus of newborn 8


External Ids:

Disease Ontology8 DOID:2382
MeSH34 D007647
NCIt39 C84799

Related Diseases for Kernicterus

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17GeneCards, 18GeneDecks
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Diseases in the Kernicterus Due to Isoimmunization family:

kernicterus

Diseases related to Kernicterus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1neonatal jaundice30.7RHD, UGT1A1, G6PD
2crigler-najjar syndrome30.3UGT1A1, UGT1A4
3hepatitis30.1UGT1A1
4crigler najjar syndrome, type 229.8UGT1A1, UGT1A4
5liver cirrhosis29.8ALB
6gilbert syndrome29.8G6PD, UGT1A4, UGT1A1, UGT1A7
7hereditary spherocytosis29.8G6PD, UGT1A1, RHD
8hemolytic anemia29.8RHD, UGT1A1, G6PD
9kernicterus due to isoimmunization10.5
10cerebritis10.2
11blood group incompatibility10.2
12neuronitis10.1
13hepatitis a10.1
14cerebral palsy athetoid10.1
15galactosemia10.0ALB
16glucosephosphate dehydrogenase deficiency10.0G6PD, UGT1A1
17cholelithiasis10.0UGT1A6, UGT1A1
18senile cataract10.0G6PD
19alpha thalassemia10.0UGT1A1, G6PD
20neutropenia10.0UGT1A1, UGT1A6
21colon cancer10.0UGT1A10, UGT1A1
22diarrhea10.0UGT1A6, UGT1A1, ALB
23lung cancer10.0ALB
24bilirubin metabolic disorder10.0G6PD, UGT1A1, UGT1A7, ALB
25hereditary elliptocytosis10.0G6PD, RHD
26beta thalassemia10.0RHD, UGT1A1, G6PD
27sickle cell disease10.0G6PD, UGT1A1, RHD
28hyperhomocysteinemia10.0RHD, ALB
29autoimmune hemolytic anemia10.0RHCE, G6PD
30hepatitis c10.0ALB, UGT1A7, UGT1A9
31rh isoimmunization10.0RHD, RHCE
32deficiency anemia10.0ALB, RHCE, RHD, G6PD
33rheumatic fever9.9
34congenital hypothyroidism9.9
35central pontine myelinolysis9.9
36adult syndrome9.9
37aphasia9.9
38cerebral palsy9.9
39congenital hemolytic anemia9.9
40hypothyroidism9.9
41liver disease9.9
42viral hepatitis9.9
43lucey-driscoll syndrome9.9

Graphical network of the top 20 diseases related to Kernicterus:



Diseases related to kernicterus

Clinical Features for Kernicterus

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Drugs & Therapeutics for Kernicterus

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Kernicterus

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Anatomical Context for Kernicterus

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32MalaCards
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MalaCards organs/tissues related to Kernicterus:

32
Brain, Globus pallidus, Liver, Breast, Endothelial

Animal Models for Kernicterus or affiliated genes

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Publications for Kernicterus

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50PubMed
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Articles related to Kernicterus:

(show top 50)    (show all 333)
idTitleAuthorsYear
1
MRI findings in kernicterus. (22990632)
2013
2
Severe neonatal hyperbilirubinemia and kernicterus: are these still problems in the third millennium? (21968213)
2011
3
Birth-related syndromes of athetosis and kernicterus. (21496597)
2011
4
Prevention of acute bilirubin encephalopathy and kernicterus in newborns. Position Statement #3049. NANN Board of Directors, March 2010. (20505419)
2010
5
Obstetric outcome in Danish children with a validated diagnosis of kernicterus. (19639464)
2009
6
Kernicterus prevention. (17356435)
2007
7
Kernicterus associated with hereditary spherocytosis and UGT1A1 promoter polymorphism. (16735790)
2006
8
Single photon emission computed tomography and serial MRI in preterm infants with kernicterus. (16481141)
2006
9
1H MR spectroscopic characteristics of kernicterus: a possible metabolic signature. (15956531)
2005
10
Neurological complications of kernicterus. (16225171)
2005
11
Definition of the clinical spectrum of kernicterus and bilirubin-induced neurologic dysfunction (BIND). (15578034)
2005
12
Cost-effectiveness of strategies that are intended to prevent kernicterus in newborn infants. (15466085)
2004
13
Hyperbilirubinemia and kernicterus: 50 years later. (15231941)
2004
14
Revised guidance to help prevent kernicterus. (15341024)
2004
15
System-based approach to management of neonatal jaundice and prevention of kernicterus. (12006952)
2002
16
Magnetic resonance imaging and kernicterus. (11875162)
2002
17
Magnetic resonance imaging in three children with kernicterus. (11704404)
2001
18
Current drug treatment options in neonatal hyperbilirubinaemia and the prevention of kernicterus. (9664196)
1998
19
Changing pattern of neonatal jaundice and kernicterus in Chinese neonates. (9594246)
1997
20
Hemolytic jaundice due to G6PD deficiency causing kernicterus in a female newborn. (7597488)
1995
21
Experimental studies on kernicterus in thiamine-deficient Gunn rats. (3508730)
1987
22
Value and limitations of bilirubin binding capacity in predicting the development of kernicterus. (6466218)
1984
23
Singapore kernicterus. (262490)
1979
24
The pathochemistry of kernicterus. (43803)
1979
25
Determination of unbound bilirubin and the prevention of kernicterus. (821551)
1976
26
Letter: Idiopathic hyperbilirubinemia and phototherapy--evidence suggesting a decreased incidence of kernicterus. (4453476)
1974
27
Kernicterus: high incidence in premature infants with low serum bilirubin concentrations. (5422114)
1970
28
The role of infection and anoxia in kernicterus. (5276928)
1970
29
An electron microscopic and radioautographic study on experimental kernicterus. I. Bilirubin transport via astroglia. (5815579)
1969
30
Studies in kernicterus. II. The determination of the saturation of serum albumin with bilirubin. (5762885)
1969
31
Hyperbilirubinemia and kernicterus in glucose-6-phosphate dehydrogenase-deficient infants in Singapore. (5652917)
1968
32
Experimental studies on the development of kernicterus. (5692114)
1968
33
Serum albumin reserve PSP dye binding capacity in infants with kernicterus. (6067403)
1967
34
The relationship of hypercapnia to the production of kernicterus. (6069979)
1967
35
Ultrastructural studies in experimental kernicterus. (5327996)
1966
36
Singapore kernicterus--the position in 1965. (5856482)
1965
37
Extraneural lesions associated with neonatal hyperbilirubinemia and kernicterus. (13868270)
1962
38
Kernicterus. (13641893)
1959
39
Constitutional nonhemolytic hyperbilirubinemia with findings resembling kernicterus. (13605323)
1959
40
Exchange transfusion for prevention of kernicterus in hyperbilirubinemia of the premature and newborn infants]. (13543307)
1958
41
Hyperbilirubinemia and kernicterus in prematures. (13463443)
1957
42
Investigation of amino aciduria in erythroblastosis foetalis and its possible relationship to kernicterus. (13450737)
1957
43
Kernicterus. (13462028)
1957
44
The prevention of kernicterus in the premature; hyperbilirubinaemia unassociated with blood group incompatibility. (13319838)
1956
45
Congenital cirrhosis of the liver with kernicterus; report of two cases in siblings with a discussion of the relationship to so-called neonatal hepatitis and to iso-immunization disease. (13268609)
1955
46
Kernicterus, with special reference to double exsanguination transfusions. (13213450)
1954
47
Congenital familial nonhemolytic jaundice with kernicterus. (12983120)
1952
48
Intravascular hemagglutination; experimental and clinical observations, with special reference to the pathogenesis of kernicterus. (14791589)
1950
49
Pathogenesis of kernicterus. (21026824)
1946
50
Kernicterus in erythroblastosis fetalis. (21002160)
1946

Genetic Variations for Kernicterus

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Expression for genes affiliated with Kernicterus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Kernicterus

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Pathways for genes affiliated with Kernicterus

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49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 29KEGG
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Pathways related to Kernicterus according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0UGT1A1, UGT1A9
210.0UGT1A4, UGT1A9
3
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10.0UGT1A4, UGT1A9
4
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9.9UGT1A4, UGT1A10
5
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9.9UGT1A1, UGT1A8
6
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9.6UGT1A10, UGT1A6, UGT1A9
79.5UGT1A8, UGT1A10, UGT1A3
8
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9.5UGT1A9, UGT1A1, UGT1A10, UGT1A3
9
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9.4UGT1A1, UGT1A6, UGT1A4, UGT1A9
10
Hide members
8.8UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A3
118.7UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A10, UGT1A3
12
Hide members
8.6UGT1A9, UGT1A4, UGT1A8, UGT1A1, UGT1A10, UGT2B28
13
Acetaminophen metabolism
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8.5UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
14
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8.2UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
15
Hide members
7.3UGT1A1, UGT1A5, UGT1A10, UGT2B28, UGT2A3, UGT1A7
16
Hide members
7.3UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
17
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7.3UGT1A6, UGT1A1, UGT1A5, UGT1A10, UGT2B28, UGT2A3
18
Hide members
7.1G6PD, UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1

Compounds for genes affiliated with Kernicterus

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44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Kernicterus according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1n-acetylbenzidine4410.1UGT1A1, UGT1A9, UGT1A4
2sn38 glucuronide4410.0UGT1A9, UGT1A7, UGT1A1
3acetaminophen glucuronide44 2411.0UGT1A6, UGT1A1, UGT1A9
4Ezogabine 119.9UGT1A3, UGT1A1, UGT1A4, UGT1A9
51-naphthol449.9UGT1A9, UGT1A6, UGT1A1
6flurbiprofen44 28 49 1112.9UGT1A9, ALB, UGT1A3, UGT1A1
74-methylumbelliferone449.8UGT1A6, UGT1A1, UGT1A9
8benzidine449.8UGT1A6, UGT1A9, UGT1A1, UGT1A4
9etodolac44 1110.8UGT1A9, UGT1A10, UGT1A3, ALB
10lamotrigine44 1110.7UGT1A4, UGT1A6, UGT1A1, UGT1A3
11phenol44 2410.7UGT1A9, UGT1A1, G6PD, UGT1A6
12trifluoperazine44 28 1111.7UGT1A9, UGT1A6, UGT1A4, UGT1A1
13udp glucuronic acid449.6UGT1A10, UGT1A8, UGT1A1, UGT1A6
14ibuprofen44 28 49 11 2413.6ALB, UGT1A9, UGT1A3, UGT1A1
15sulfamethoxazole44 49 1111.6ALB, UGT1A9, G6PD
16p-nitrophenol44 1110.5UGT1A3, UGT1A1, UGT1A4, UGT1A6, UGT1A9
17mycophenolate mofetil44 49 1111.5UGT1A8, UGT1A9, UGT1A10, UGT1A1, ALB
18irinotecan44 49 1111.5UGT1A7, UGT1A9, UGT1A1, UGT1A6, ALB
19benzo(a)pyrene449.4UGT1A7, UGT1A1, UGT1A6, UGT1A9
20amine449.4UGT1A3, UGT1A4, UGT1A1, UGT1A7
21uridine44 11 2411.4UGT1A9, UGT1A4, UGT1A1, UGT1A6, UGT1A7
22losartan44 49 28 1112.4ALB, UGT1A10, UGT1A1, UGT1A3
23diclofenac44 28 49 1112.3UGT1A3, ALB, UGT1A9, UGT1A6, UGT1A1, UGT1A4
24mycophenolic acid44 49 1111.2UGT1A1, ALB, UGT1A8, UGT1A10, UGT1A7, UGT1A9
25tamoxifen44 49 28 1112.2G6PD, UGT1A9, UGT1A4, UGT1A3, UGT1A6, UGT1A1
26morphine44 49 28 1112.1UGT1A6, UGT1A8, UGT1A3, UGT1A1, UGT1A4, UGT1A9
27acetaminophen44 2 49 11 2413.0UGT1A10, UGT1A7, UGT1A1, UGT1A6, UGT1A4, G6PD
28glucuronide449.0UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A10, UGT1A7
29uridine diphosphate448.9UGT1A4, UGT1A7, UGT1A10, UGT1A1, UGT1A9, UGT1A3
30n-hydroxy phip448.9UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
31troglitazone44 28 59 1111.9UGT1A9, UGT1A4, UGT1A8, UGT1A3, UGT1A10, UGT1A1
32propofol44 49 1110.7ALB, UGT1A3, UGT1A10, UGT1A1, UGT1A6, UGT1A8
33ethyl glucuronide44 249.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
34cotinine44 249.6UGT1A4, UGT1A9, UGT1A8, UGT1A6, UGT1A1, UGT1A10
35imipramine44 49 28 11 2412.6UGT1A9, UGT1A6, UGT1A3, UGT1A7, UGT1A10, UGT1A1
36nicotine44 49 28 1111.5UGT1A3, UGT1A7, UGT1A9, UGT1A6, UGT1A10, UGT1A1
37valproic acid44 49 11 2411.4UGT1A4, UGT1A9, ALB, UGT1A3, UGT1A7, UGT1A10
38etiocholanolone44 248.7UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
39androsterone glucuronide44 248.7UGT1A10, UGT2B28, UGT2A3, UGT1A7, UGT1A3, UGT2A1
403-alpha-androstanediol glucuronide44 248.7UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
41estriol28 11 249.7UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
422-methoxyestradiol44 59 249.7UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
43(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)247.7UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5, UGT1A10
44bilirubin diglucuronide44 248.7UGT2B28, UGT2A3, UGT1A7, UGT1A3, UGT2A1, UGT1A10
45aldosterone 18-glucuronide44 248.7UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
46codeine44 49 28 11 2411.7UGT2A1, UGT1A3, UGT1A9, UGT1A4, UGT1A8, UGT1A6
47retinoic acid44 248.6UGT2B28, UGT2A3, UGT1A9, UGT1A5, UGT1A1, UGT1A7
48estrone44 28 11 2410.5UGT1A10, UGT2B28, UGT2A3, UGT1A7, UGT1A3, UGT2A1
49estradiol44 11 249.5UGT1A5, UGT1A10, UGT2A1, UGT1A3, UGT1A7, UGT2A3
50testosterone44 59 11 2410.3UGT1A4, UGT1A8, UGT1A9, G6PD, UGT1A1, UGT1A5

GO Terms for genes affiliated with Kernicterus

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16Gene Ontology
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Cellular components related to Kernicterus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular membrane-bounded organelleGO:0432319.1UGT1A5, UGT1A6, UGT1A8, UGT1A9, G6PD
2endoplasmic reticulum membraneGO:0057897.6UGT1A3, UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1
3integral to membraneGO:0160215.5UGT1A5, UGT1A6, UGT1A8, UGT3A1, UGT1A4, UGT1A9

Biological processes related to Kernicterus according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1coumarin metabolic processGO:0098049.8UGT1A7, UGT1A8
2negative regulation of steroid metabolic processGO:0459399.6UGT1A1, UGT1A8
3negative regulation of fatty acid metabolic processGO:0459229.5UGT1A9, UGT1A8, UGT1A7
4negative regulation of catalytic activityGO:0430869.4UGT1A7, UGT1A1, UGT1A8, UGT1A9
5flavonoid glucuronidationGO:0526969.3UGT1A9, UGT1A8, UGT1A1, UGT1A7, UGT1A3
6xenobiotic glucuronidationGO:0526979.3UGT1A3, UGT1A7, UGT1A1, UGT1A8, UGT1A9
7drug metabolic processGO:0171449.3UGT1A7, UGT1A1, UGT1A8, UGT1A9
8flavone metabolic processGO:0515529.2UGT1A9, UGT1A8, UGT1A1, UGT1A10, UGT1A7
9retinoic acid metabolic processGO:0425739.2UGT1A9, UGT1A8, UGT1A1, UGT1A7, UGT1A3
10cellular glucuronidationGO:0526959.2UGT1A4, UGT1A6, UGT1A1, UGT1A10, UGT2A3, UGT2A1
11xenobiotic metabolic processGO:0068059.1UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A5, UGT2B28
12metabolic processGO:0081528.9UGT2A1, UGT1A9, UGT1A6, UGT1A5, UGT1A10, UGT2B28

Molecular functions related to Kernicterus according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1fatty acid bindingGO:0055049.9ALB, UGT1A8
2ammonium transmembrane transporter activityGO:0085199.4RHD, RHCE
3enzyme inhibitor activityGO:0048579.4UGT1A7, UGT1A1, UGT1A8, UGT1A9
4drug bindingGO:0081449.3ALB, UGT1A7, UGT1A8
5UDP-glycosyltransferase activityGO:0081948.8UGT3A1, UGT3A2, UGT1A3
6retinoic acid bindingGO:0019728.4UGT1A3, UGT1A7, UGT1A10, UGT1A1, UGT1A6, UGT1A8
7protein heterodimerization activityGO:0469828.3UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
8enzyme bindingGO:0198998.2UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
9protein homodimerization activityGO:0428038.1G6PD, UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1
10glucuronosyltransferase activityGO:0150206.0UGT2A1, UGT1A9, UGT1A4, UGT3A1, UGT1A8, UGT1A3

Products for genes affiliated with Kernicterus

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Sources for Kernicterus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet