MCID: KRN004
MIFTS: 46

Kernicterus malady

Categories: Rare diseases, Fetal diseases, Neuronal diseases, Metabolic diseases, Cancer diseases, Blood diseases, Skin diseases

Aliases & Classifications for Kernicterus

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Sources:
2CDC, 11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 39MeSH, 45NCIt, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Kernicterus:

Name: Kernicterus 11 48 54 50 2 39 13 68
Bilirubin Encephalopathy 11 48 54
 
Hyperbilirubinemic Encephalopathy 48

Characteristics:

Orphanet epidemiological data:

54
kernicterus:
Inheritance: Not applicable; Age of onset: Neonatal

Classifications:



External Ids:

Disease Ontology11 DOID:2382
ICD1030 P57, P57.9, P57.8
MeSH39 D007647
NCIt45 C84799
Orphanet54 ORPHA415286
ICD10 via Orphanet31 P57.9

Summaries for Kernicterus

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NIH Rare Diseases:48 Kernicterus is a rare condition that affects the brain. it refers to a form of brain damage that occurs when neonatal jaundice goes untreated for too long. the severity of the condition and the associated signs and symptoms vary significantly from person to person. people living with kernicterus may experience athetoid cerebral palsy, hearing loss, intellectual disability, vision abnormalities, and behavioral difficulties. approximately 60% of all newborn babies will have jaundice, a condition that is characterized by high level of bilirubin in the blood. risk factors for severe jaundice and higher bilirubin levels include premature birth (before 37 weeks); darker skin color; east asian or mediterranean descent; feeding difficulties; jaundice in a sibling; bruising at birth; and a mother with an o blood type or rh negative blood factor. early detection and management of jaundice can prevent kernicterus. last updated: 3/16/2016

MalaCards based summary: Kernicterus, also known as bilirubin encephalopathy, is related to crigler-najjar syndrome, type ii and kernicterus due to isoimmunization, and has symptoms including icterus An important gene associated with Kernicterus is UGT1A1 (UDP Glucuronosyltransferase Family 1 Member A1), and among its related pathways are Central carbon metabolism in cancer and Nicotine Pathway, Pharmacokinetics. Affiliated tissues include brain, skin and globus pallidus, and related mouse phenotype Decreased shRNA abundance (Z-score < -2).

Disease Ontology:11 A brain disease that is characterized by hyperbilirubinemia-induced brain dysfunction.

Wikipedia:71 Kernicterus is a bilirubin-induced brain dysfunction. The term was coined in 1904 by Schmorl. Bilirubin... more...

Related Diseases for Kernicterus

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Diseases in the Kernicterus family:

Kernicterus Due to Isoimmunization

Diseases related to Kernicterus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1crigler-najjar syndrome, type ii31.4UGT1A1, UGT1A4, UGT1A6, UGT1A9
2kernicterus due to isoimmunization12.1
3cerebral palsy athetoid10.9
4crigler-najjar syndrome, type i10.8
5lucey-driscoll syndrome10.8
6neonatal jaundice10.2
7endometriosis of uterus10.2G6PD, UGT1A1
8glandular cystitis10.1G6PD, UGT1A1
9encephalopathy10.1
10krauss herman holmes syndrome10.1ALB, G6PD
11kohler's disease10.1ALB, UGT1A1
12heinz body anemia10.1G6PD, UGT1A1
13punctate epithelial keratoconjunctivitis10.1UGT1A1, UGT1A6
14neutropenia, severe congenital 2, autosomal dominant10.1UGT1A1, UGT1A6
15tk2-related mitochondrial dna depletion syndrome, myopathic form10.1G6PD, UGT1A1
16vagus nerve neoplasm10.1G6PD, SLC4A1, UGT1A1
17tenosynovitis10.0ALB, G6PD
18basal ganglia cerebrovascular disease10.0ALB, RHCE
19mutism10.0G6PD, RHCE, SLC4A1
20fetal hemoglobin quantitative trait locus 110.0G6PD, UGT1A1, UGT1A6
21echolalia10.0ALB, RHCE
22borderline leprosy9.9ALB, UGT1A1, UGT1A6
23adenosine triphosphate, elevated, of erythrocytes9.9G6PD, PKM, SLC4A1
24acute dacryoadenitis9.9UGT1A1, UGT1A6
25brain injury9.9
26cerebritis9.9
27blood group incompatibility9.9
28cerebral artery occlusion9.8PKM, UGT1A1, UGT1A6
29hyperbilirubinemia, familial transient neonatal9.8UGT1A1, UGT1A4, UGT1A6, UGT1A9
30hepatitis9.8
31neuronitis9.8
32pyelitis9.8ALB, G6PD, UGT1A1, UGT1A6
33pyeloureteritis cystica9.7G6PD, UGT1A1, UGT1A4, UGT1A6, UGT1A9
34cerebral palsy9.6
35hemolytic anemia9.6
36congenital hypothyroidism9.6
37aphasia9.6
38hereditary spherocytosis9.6
39hypothyroidism9.6
40rheumatic fever9.6
41viral hepatitis9.6
42congenital hemolytic anemia9.6
43central pontine myelinolysis9.6
44athetosis9.6
45anoxia9.6
46endotheliitis9.6
47fulminant viral hepatitis9.6
48renal artery disease8.8ALB, G6PD, PKM, RHCE, SLC4A1, UGT1A1

Graphical network of the top 20 diseases related to Kernicterus:



Diseases related to kernicterus

Symptoms & Phenotypes for Kernicterus

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UMLS symptoms related to Kernicterus:


icterus

GenomeRNAi Phenotypes related to Kernicterus according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-848.9RHCE, SLC4A1, UGT1A1

Drugs & Therapeutics for Kernicterus

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Drugs for Kernicterus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AntioxidantsPhase 43050
2
BilirubinPhase 4116635-65-45280352
Synonyms:
(4Z,15Z)-Bilirubin IXa
(Z,Z)-Bilirubin IXa
1,10,19,22,23,24-Hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionate
1,10,19,22,23,24-Hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionic acid
2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8,12-dipropanoate
2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8,12-dipropanoic acid
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoate
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
 
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-[(Z)-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-1H-pyrrol-2-yl)methyl)-4-methyl-5-[(Z)-(4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene
3-[2-[[3-(2-Carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate
3-[2-[[3-(2-Carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
3-[2-[[3-(2-Carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate
3-[2-[[3-(2-Carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
Bilirubin
Bilirubin IX-alpha
Cholerythrin
Hematoidin
3AntibodiesPhase 46394
4Rho(D) Immune GlobulinPhase 4326
5Protective AgentsPhase 47443
6gamma-GlobulinsPhase 4326
7Pharmaceutical SolutionsPhase 48192
8ImmunoglobulinsPhase 46394
9Immunoglobulins, IntravenousPhase 4333
10
Darbepoetin alfaapproved, investigationalPhase 2, Phase 317711096-26-7, 209810-58-2
Synonyms:
 
Darbepoetin
Darbepoetin alfa,recombinant
11Tin mesoporphyrinPhase 314
12
TinPhase 3737440-31-5
Synonyms:
CI Pigment metal 5
Haro Mix ZT-514
Innohep
Metallic tin
SN
 
Silver matt powder
Stanum
Tin flake
Tin powder
Tindamax
ZINN
13HematinicsPhase 2, Phase 31684
14
Mentholapproved26062216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol
15
Carbon monoxideapproved124630-08-0281
Synonyms:
CO
 
Carbon monoxide
Carboneum oxygenisatum
carbon(II) oxide
16Neurotransmitter Agents18340
17Antimetabolites12054

Interventional clinical trials:

(show all 13)
idNameStatusNCT IDPhase
1Use of a New Phototherapy Device (BBloo®) for the Treatment of Hyperbilirubinemia in the Newborn InfantUnknown statusNCT02156050Phase 4
2Efficacy of High-dose Intravenous Immunoglobulin Therapy for Hyperbilirubinemia Due Rh Hemolytic DiseaseCompletedNCT00288600Phase 4
3Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase DeficiencyRecruitingNCT02594904Phase 4
4Efficacy and Safety of Stannsoporfin in NeonatesCompletedNCT02685137Phase 3
5EPO-4-Rhesus: Role of Darbepoetin Alfa in Reducing Late Anaemia in Neonates With Red Blood Cell Alloimmunization After Intrauterine TransfusionsNot yet recruitingNCT03104426Phase 2, Phase 3
6New Phototherapy Device to Treat Patients With Crigler-Najjar DiseaseUnknown statusNCT02356978
7Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment.Unknown statusNCT02224586
8Does Maternal Instruction Prevent Kernicterus in Nigeria?CompletedNCT02713464
9Determining Prevalence of Acute Bilirubin Encephalopathy in Developing CountriesCompletedNCT01754688
10Follow-up of Extreme Neonatal Hyperbilirubinemia in 5-10 Year Old Children: a Danish Population Based StudyCompletedNCT01599611
11Clinical and Developmental Outcomes of Babies Who Became Yellow in the First Month of LifeCompletedNCT02927093
12Implementation of a Transcutaneous BilirubinometerCompletedNCT01622699
13Bilirubin Binding Capacity to Assess Bilirubin Load in Preterm InfantsRecruitingNCT02691156

Search NIH Clinical Center for Kernicterus


Cochrane evidence based reviews: kernicterus

Genetic Tests for Kernicterus

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Anatomical Context for Kernicterus

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MalaCards organs/tissues related to Kernicterus:

36
Brain, Skin, Globus pallidus, Breast, Liver, Endothelial

Publications for Kernicterus

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Articles related to Kernicterus:

(show top 50)    (show all 346)
idTitleAuthorsYear
1
Chronic kernicterus: magnetic resonance imaging findings. (28057969)
2016
2
Kernicterus in Neonatal Jaundice-Finding the Needle in the Haystack. (26945202)
2016
3
Glucose-6-Phosphate Dehydrogenase Deficiency and the Need for a Novel Treatment to Prevent Kernicterus. (27235212)
2016
4
A new rat model of neonatal bilirubin encephalopathy (kernicterus). (27746217)
2016
5
Serum unbound bilirubin as a predictor for clinical kernicterus in extremely low birth weight infants at a late age in the neonatal intensive care unit. (25638486)
2015
6
Current incidence of clinical kernicterus in preterm infants in Japan. (26113317)
2015
7
Brain magnetic resonance imaging and magnetic resonance spectroscopy findings of children with kernicterus. (25745520)
2015
8
The Blockade of NF-I_B Activation by a Specific Inhibitory Peptide has a Strong Neuroprotective Role in a Sprague-Dawley Rat Kernicterus Model. (26499797)
2015
9
Prevention of Kernicterus in South Asia: role of neonatal G6PD deficiency and its identification. (24763814)
2014
10
The enigma of low bilirubin kernicterus in premature infants: Why does it still occur, and is it preventable? (25267279)
2014
11
A novel newborn rat kernicterus model created by injecting a bilirubin solution into the cisterna magna. (24796550)
2014
12
Why is kernicterus still a major cause of death and disability in low-income and middle-income countries? (25123403)
2014
13
What causes increased expression of VEGF and VEGF-R in a case report? Comment on: "New autopsy findings in different brain regions of a preterm neonate with kernicterus: neurovascular alterations and up-regulation of efflux transporters". (24739376)
2014
14
Acute kernicterus in a neonate with O/B blood group incompatibility and a mutation in SLC4A1. (23878048)
2013
15
Use of the extended parallel processing model to evaluate culturally relevant kernicterus messages. (23237614)
2013
16
Jaundice and kernicterus in the moderately preterm infant. (24182955)
2013
17
Neonatal death suspected to be from sepsis was found to be kernicterus with G6PD deficiency. (24218468)
2013
18
MRI findings in kernicterus. (22990632)
2013
19
New autopsy findings in different brain regions of a preterm neonate with kernicterus: neurovascular alterations and up-regulation of efflux transporters. (24138949)
2013
20
Low bilirubin kernicterus with sepsis and hypoalbuminaemia. (23616313)
2013
21
Cotrimoxazole and neonatal kernicterus: a review. (24099411)
2013
22
MRI findings in a dog with kernicterus. (23690488)
2013
23
Cost-effectiveness analysis of a system-based approach for managing neonatal jaundice and preventing kernicterus in Ontario. (23277747)
2012
24
Medical education content required for kernicterus risk recognition. (23056881)
2012
25
The Italian Registry of kernicterus and hyperbilirubinaemia. (22958040)
2012
26
Cerebellar axon/myelin loss, angiogenic sprouting, and neuronal increase of vascular endothelial growth factor in a preterm infant with kernicterus. (22190497)
2012
27
Evidence suggests there was not a "resurgence" of kernicterus in the 1990s. (21444599)
2011
28
Severe neonatal hyperbilirubinemia and kernicterus: are these still problems in the third millennium? (21968213)
2011
29
Evaluation of oxidant and antioxidant status in infants with hyperbilirubinemia and kernicterus. (21393350)
2011
30
Birth-related syndromes of athetosis and kernicterus. (21496597)
2011
31
Are recommended phototherapy thresholds safe enough for extremely low birth weight (ELBW) infants? A report on 2 ELBW infants with kernicterus despite only moderate hyperbilirubinemia. (20639681)
2011
32
Prevention of acute bilirubin encephalopathy and kernicterus in newborns: position statement #3049. (22123452)
2011
33
Prevention of acute bilirubin encephalopathy and kernicterus in newborns. Position Statement #3049. NANN Board of Directors, March 2010. (20505419)
2010
34
Magnetic resonance imaging of bilateral mesial temporal sclerosis in chronic kernicterus. (21887194)
2009
35
Fatal kernicterus in a girl deficient in glucose-6-phosphate dehydrogenase: a paradigm of synergistic heterozygosity. (19324225)
2009
36
Changes in the globus pallidus in chronic kernicterus. (21887193)
2009
37
Severe hyperbilirubinaemia and kernicterus: more caution is needed in newborn jaundice surveillance. (19772008)
2009
38
A proposal to prevent severe neonatal hyperbilirubinemia and kernicterus. (19177062)
2009
39
Obstetric outcome in Danish children with a validated diagnosis of kernicterus. (19639464)
2009
40
Synopsis report from the pilot USA Kernicterus Registry. (19177058)
2009
41
Kernicterus in preterm infants. (19433515)
2009
42
Neonatal hyperbilirubinemia and kernicterus - not gone but sometimes forgotten. (19833460)
2009
43
Kernicterus in the 21st century: frequently asked questions. (19177056)
2009
44
Clinical report from the pilot USA Kernicterus Registry (1992 to 2004). (19177057)
2009
45
Trends in hospitalizations for neonatal jaundice and kernicterus in the United States, 1988-2005. (19171618)
2009
46
Prevention of kernicterus: new guidelines and the critical role of family physicians. (18411389)
2008
47
Heterologous assisted reproduction and kernicterus: the unlucky coincidence reveals an ethical dilemma. (18330816)
2008
48
A new animal model of hemolytic hyperbilirubinemia-induced bilirubin encephalopathy (kernicterus). (18458656)
2008
49
Kernicterus by glucose-6-phosphate dehydrogenase deficiency: a case report and review of the literature. (18460213)
2008
50
Israel guidelines for the management of neonatal hyperbilirubinemia and prevention of kernicterus. (18322551)
2008

Variations for Kernicterus

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Expression for genes affiliated with Kernicterus

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Search GEO for disease gene expression data for Kernicterus.

Pathways for genes affiliated with Kernicterus

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Pathways related to Kernicterus according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathwaysScoreTop Affiliating Genes
19.5G6PD, PKM
2
Show member pathways
9.5UGT1A4, UGT1A9
3
Show member pathways
9.2UGT1A1, UGT1A4, UGT1A9
49.0UGT1A4, UGT1A6, UGT1A9
5
Show member pathways
8.7UGT1A1, UGT1A4, UGT1A6, UGT1A9
6
Show member pathways
8.7UGT1A1, UGT1A4, UGT1A6, UGT1A9
7
Show member pathways
8.7UGT1A1, UGT1A4, UGT1A6, UGT1A9
8
Show member pathways
8.7UGT1A1, UGT1A4, UGT1A6, UGT1A9
9
Show member pathways
8.7UGT1A1, UGT1A4, UGT1A6, UGT1A9
108.7UGT1A1, UGT1A4, UGT1A6, UGT1A9
11
Show member pathways
8.7UGT1A1, UGT1A4, UGT1A6, UGT1A9
128.7UGT1A1, UGT1A4, UGT1A6, UGT1A9
13
Show member pathways
8.7UGT1A1, UGT1A4, UGT1A6, UGT1A9
14
Show member pathways
8.7UGT1A1, UGT1A4, UGT1A6, UGT1A9
158.3G6PD, UGT1A1, UGT1A4, UGT1A6, UGT1A9
167.7G6PD, PKM, UGT1A1, UGT1A4, UGT1A6, UGT1A9
17
Show member pathways
6.9ALB, G6PD, PKM, SLC4A1, UGT1A1, UGT1A4

GO Terms for genes affiliated with Kernicterus

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Cellular components related to Kernicterus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:00057899.4UGT1A1, UGT1A4, UGT1A6, UGT1A9
2endoplasmic reticulumGO:00057839.1ALB, UGT1A1, UGT1A4, UGT1A6, UGT1A9
3extracellular exosomeGO:00700628.4ALB, G6PD, PKM, SLC4A1, UGT1A6, UGT1A9
4intracellular membrane-bounded organelleGO:00432318.3G6PD, UGT1A1, UGT1A4, UGT1A6, UGT1A9

Biological processes related to Kernicterus according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1flavone metabolic processGO:005155210.4UGT1A1, UGT1A9
2flavonoid glucuronidationGO:005269610.4UGT1A1, UGT1A9
3bilirubin conjugationGO:000678910.3UGT1A1, UGT1A4
4heme catabolic processGO:004216710.3UGT1A1, UGT1A4
5animal organ regenerationGO:003110010.2PKM, UGT1A1
6retinoic acid metabolic processGO:00425739.9UGT1A1, UGT1A9
7cellular glucuronidationGO:00526959.3UGT1A1, UGT1A4, UGT1A6, UGT1A9
8xenobiotic glucuronidationGO:00526978.7UGT1A1, UGT1A4, UGT1A6, UGT1A9
9metabolic processGO:00081528.4PKM, UGT1A1, UGT1A4, UGT1A6, UGT1A9

Molecular functions related to Kernicterus according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1glucuronosyltransferase activityGO:00150209.4UGT1A1, UGT1A4, UGT1A6, UGT1A9
2protein heterodimerization activityGO:00469829.4UGT1A1, UGT1A4, UGT1A6, UGT1A9
3retinoic acid bindingGO:00019729.4UGT1A1, UGT1A4, UGT1A6, UGT1A9
4transferase activity, transferring glycosyl groupsGO:00167579.1UGT1A1, UGT1A4, UGT1A6, UGT1A9
5transferase activity, transferring hexosyl groupsGO:00167588.7UGT1A1, UGT1A4, UGT1A6, UGT1A9
6transferase activityGO:00167408.6PKM, UGT1A1, UGT1A4, UGT1A6, UGT1A9
7protein homodimerization activityGO:00428038.6G6PD, SLC4A1, UGT1A1, UGT1A4, UGT1A6, UGT1A9

Sources for Kernicterus

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet