MCID: KRN004
MIFTS: 43

Kernicterus malady

Categories: Rare diseases, Fetal diseases, Neuronal diseases, Metabolic diseases, Cancer diseases, Blood diseases, Skin diseases

Aliases & Classifications for Kernicterus

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 36MeSH, 2CDC, 65UMLS, 27ICD10, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Kernicterus:

Name: Kernicterus 10 45 47 12 51 36 2 65
Bilirubin Encephalopathy 10 45 51
Hyperbilirubinemic Encephalopathy 45
 
Kernicterus of Newborn Nos 10
Kernicterus of Newborn 10

Classifications:



External Ids:

Disease Ontology10 DOID:2382
ICD1027 P57, P57.9, P57.8
MeSH36 D007647
NCIt42 C84799
Orphanet51 415286
ICD10 via Orphanet28 P57.9
UMLS65 C0022610

Summaries for Kernicterus

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NIH Rare Diseases:45 Kernicterus is a rare condition that affects the brain. it refers to a form of brain damage that occurs when neonatal jaundice goes untreated for too long. the severity of the condition and the associated signs and symptoms vary significantly from person to person. people living with kernicterus may experience athetoid cerebral palsy, hearing loss, intellectual disability, vision abnormalities, and behavioral difficulties. approximately 60% of all newborn babies will have jaundice, a condition that is characterized by high level of bilirubin in the blood. risk factors for severe jaundice and higher bilirubin levels include premature birth (before 37 weeks); darker skin color; east asian or mediterranean descent; feeding difficulties; jaundice in a sibling; bruising at birth; and a mother with an o blood type or rh negative blood factor. early detection and management of jaundice can prevent kernicterus. last updated: 3/16/2016

MalaCards based summary: Kernicterus, also known as bilirubin encephalopathy, is related to crigler-najjar syndrome, type ii and crigler-najjar syndrome, type i. An important gene associated with Kernicterus is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways are Valproic Acid Pathway, Pharmacokinetics and Nicotine Pathway, Pharmacokinetics. Affiliated tissues include brain, skin and bone.

Wikipedia:68 Kernicterus is a bilirubin-induced brain dysfunction. Bilirubin is a highly neurotoxic substance that... more...

Related Diseases for Kernicterus

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Diseases in the Kernicterus family:

Kernicterus Due to Isoimmunization

Diseases related to Kernicterus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 270)
idRelated DiseaseScoreTop Affiliating Genes
1crigler-najjar syndrome, type ii30.7UGT1A1, UGT1A4, UGT1A9
2crigler-najjar syndrome, type i30.7UGT1A1, UGT1A4, UGT1A9
3endometrial adenocarcinoma30.3G6PD, UGT1A1
4horner's syndrome29.8ABCB1, CYP3A4
5myelodysplastic syndrome28.9ABCB1, CYP3A4, GSTM1
6kernicterus due to isoimmunization12.6
7corneal disease10.4G6PD, UGT1A1
8mental retardation, x-linked 310.3G6PD, UGT1A1
9lucey-driscoll syndrome10.3
10kosztolanyi syndrome10.3ALB, G6PD
11iron deficiency anemia10.3ALB, UGT1A1
12pseudohypoparathyroidism10.3G6PD, SLC4A1
13pyruvate kinase deficiency10.3G6PD, SLC4A1
14congenital nonspherocytic hemolytic anemia10.2G6PD, UGT1A1
15breast cancer10.2
16prostatitis10.2
17efavirenz toxicity10.2ABCB1, UGT1A1
18hepatitis10.2
19leukemia10.2
20cervicitis10.2
21adenocarcinoma10.2
22dermatitis10.2
23endotheliitis10.2
24thalassemia-beta, dominant inclusion-body10.2G6PD, UGT1A1
25auditory system disease10.1ALB, G6PD, UGT1A1
26tetanic cataract10.1ABCB1, CYP3A4
27neurologic diseases10.1ABCB1, CYP3A4
28intrapelvic lymph node leukemic reticuloendotheliosis10.1G6PD, SLC4A1, UGT1A1
29progressive locomotor ataxia10.1ABCB1, CYP3A4
30colorectal cancer10.1
31prostate cancer10.1
32lymphoma10.1
33dementia10.1
34melanoma10.1
35vasculitis10.1
36queensland tick typhus10.1CYP3A4, G6PD
37trichostrongyloidiasis10.1ALB, CYP3A4
38collagen vi-related myopathy10.1ABCB1, CYP3A4
39dentin caries10.1ABCB1, CYP3A4
40hepatitis c virus10.0
41cystic fibrosis10.0
42arthritis10.0
43sinusitis10.0
44spinal muscular atrophy10.0
45colitis10.0
46myeloma10.0
47dermatomyositis10.0
48lymphoblastic leukemia10.0
49chlamydia10.0
50coloboma10.0

Graphical network of the top 20 diseases related to Kernicterus:



Diseases related to kernicterus

Symptoms for Kernicterus

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Drugs & Therapeutics for Kernicterus

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Drugs for Kernicterus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AntioxidantsPhase 42442
2AntibodiesPhase 44477
3Protective AgentsPhase 45651
4Rho(D) Immune GlobulinPhase 4206
5
BilirubinPhase 4103635-65-45280352
Synonyms:
(4Z,15Z)-Bilirubin IXa
(Z,Z)-Bilirubin IXa
1,10,19,22,23,24-Hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionate
1,10,19,22,23,24-Hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionic acid
2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8,12-dipropanoate
2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8,12-dipropanoic acid
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoate
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
 
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-[(Z)-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-1H-pyrrol-2-yl)methyl)-4-methyl-5-[(Z)-(4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene
3-[2-[[3-(2-Carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate
3-[2-[[3-(2-Carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
3-[2-[[3-(2-Carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate
3-[2-[[3-(2-Carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
Bilirubin
Bilirubin IX-alpha
Cholerythrin
Hematoidin
6Pharmaceutical SolutionsPhase 47004
7ImmunoglobulinsPhase 44477
8Immunoglobulins, IntravenousPhase 4211
9Immunologic FactorsPhase 418483
10Tin mesoporphyrinPhase 314
11
TinPhase 3357440-31-5
Synonyms:
CI Pigment metal 5
Haro Mix ZT-514
Innohep
Metallic tin
SN
 
Silver matt powder
Stanum
Tin flake
Tin powder
Tindamax
ZINN
12
Mentholapproved19992216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
999 Itch Relief
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
Absorbine Back Therapeutic Pain Relief
Absorbine Jr
Absorbine Jr Ultra Strength Pain Relieving
Absorbine Jr.
Absorbine Jr. Back
Algomend Pain Relief
Alhua Huogan Pain Relieving Patch
Aloemint Skin Aid
Amar Ice
Analgesic
Anc Neverpain External Analgesic
Anti Itch
Army Health Pain Reliever
Arthri-support
Arthri-zen Relief
Arthripain Relief
Arthritis Relief
Aspercreme Heat
Aspercreme Max No Mess Roll On
Assured Cold N Hot Pain Relief Menthol
Assured Extra Strength Cold N Hot
Assured Ice Cold Topical Analgesic
Assured Muscle Rub
Assured Pain Relief Hot Menthol
Atopalm Pain Relieving
Aurorae Healing Pain Relieving Roll-on
Avapta
Avedana Pain Relieving Roll On
Avedana Pain-relieving
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
Babyganics Cold Relief Chest Rub
Barox
Barox BODY CARE MASSAGE
Barox Body Care Massage Relax Refresh Revital
Being Well Extra Strength Menthol Heat
Bengay Ultra Strength Large Size
Bengay Ultra Strength Pain Relieving Large Size
Bengay Ultra Strength Pain Relieving Regular Size
Bengay Ultra Strength Regular Size
Bengay Vanishing Scent
Bengay Zero Degrees Menthol Pain Relieving
Bentasil SUGAR FREE BLACKCURRANT SOFT Texture
Bentasil SUGAR FREE CHERRY SOFT Texture
Bentasil SUGAR FREE HONEY LEMON SOFT Texture
Berri-freez
Besthealth Cherry
Besthealth Cough Suppressant Sugar Free Black Cherry Flavor
Besthealth Cough Suppressant Sugar Free Honey Lemon Flavor
Besthealth Honey Lemon
Besthealth Menthol
Bio 2 Brazilian Heat Brazilian Heat
Bio-scriptives Extreme Pr
Bioblast Pain Relief
Bioflexor
Biofreeze
Biofreeze Colorless
Biofreeze Colorless Roll-on
Biofreeze Roll-on
Biorelief Ice Pain Relieving
Blistex Ivarest Medicated Poison Ivy Cleansing Foam
Blue Gel Pain Relieving
Blue Ice
Blue Ice Analgesic
Blue Ice Analgesic Gel
Blue Ice Pain Relieving
Body
Budpack Muscle Rub
Budpak Muscle Rub
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Canker Complete Canker Sore Relief
Caswell No. 540
Celadrin
Cepacol Sore Throat From Post Nasal Drip
Cepacol Sore Throat Regular Strength
Ching Wan Hung Soothing Herbal Balm
Choice Personal Care Theraputic Blue Ice
Cold Hot Patch
Cold Spot Point Relief
Coldaid
Cool N Heat Patch For Back Extra Strength
Coralite Extra Strength Menthol Pain Relief Sleeve - Knee
Coralite Extra Strength Menthol Pain Relief Sleeve - Wrist
Coralite Pain Relief
Counteract Cough Drops Honey Lemon
Counteract Cough Drops Orchard Cherry
Cryogel Island Rain Natural Pain Relieving Vitaminerals
Cvs Cold Hot Medicated
Cvs Soothing Itch Relief
Cvs Sore Muscle Rub Vanishing Scent
Cvs Therapeutic Menthol Gel
Cvs Therapeutic Menthol Pain Reliever
Cvs Tropical Citrus Cough
Cvs Ultra Strength Pain Relieving
Cvs Vanishing Scent Muscle Rub
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
Dg Health Extra Strength Medicated
Dg Health Pain Relieving
Dg Ice Cold Analgesic
Diapedic Foot Treatment
DivK1c_000820
Dorflex Icy Hot Flexible, Large
Dorflex Icy Hot Flexible, Small
Dorflex Icy Hot Flexible, XL
Dr. Blue
Dt Ice Cold Analgesic
Dual Action Cherry Cough Suppressant Oral Anesthetic
Dynafreeze
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
Easy
Eb301ap Pain Relief
Eb301ct Bruise Pain Relief
Eb302 Arthritis Relief
Ecolyptus Pain Relieving Muscle Rub
Efac Pain Relieving
Elgin Pain Relief
Equaline Blue Ice Pain Relieving
Equate Menthol Extra Strength
Eros Iron Man
Eucalyptamint
Eucerin Calming Itch Relief Treatment
Extra Strength Cold N Hot Pain Relief Medicated
Extra Strength Pain Relief Therapy
Extra Strength Stopain Cold Pain Relieving
Extra Strength Stopain Cold Pain Relieving Roll On
FEMA No. 2665
Family Care Maximum Strength Medicated Anti Itch
Fast Freeze
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
Flexall Pain Relieving
Flexgen
Fluaid
Foot Works Achy Foot Massager Pain Relieving
Gold Bond Foot Extra Strength
Gold Bond Medicated Foot
Gold Bond Pain Relieving Foot
Gold Bond Pain Relieving Foot Roll On
Green Bamboo
Green Guard Cough Drop Relief
HMS1922G13
HMS2092L14
HMS502I22
HSDB 5662
HSDB 593
Halls Apple Cider
Halls Butterscotch
Halls Cherry
Halls Extra Strong Menthol
Halls Honey Lemon
Halls Ice Peppermint
Halls MENTHO-LYPTUS
Halls Melon Splash
Halls Menthol
Halls Mentholyptus
Halls Mocha Mint
Halls Naturals Honey Lemon Chamomile
Halls Plus Cherry
Halls Plus Honey
Halls Plus Strawberry
Halls Spearmint
Halls Strawberry
Halls Sugar Free Black Cherry
Halls Sugar Free Citrus Blend
Halls Sugar Free Extra Strong Menthol
Halls Sugar Free Honey Berry
Halls Sugar Free Honey Lemon
Halls Sugar Free Mountain Menthol
Halls Tropical Fruit
Hallsmelon Splash Melon Splash
Hallssugar Free Extra Sugar Free Extra Strong Menthol
Han Honey Loquat Syrup
Hanbang Cataplasma
Harmon Extra Strength Pain Relieving
Harmon Extra Strength Pain Relieving Roll-on
Headache crystals
Health Smart Medicated Foot
Herbion Naturals Honey Lemon
Herbion Naturals Honey Lemon Cough Drops
Herbion Naturals Honey-Lemon Cough Drops
Herbion Naturals Mint Cough Drops
Herbion Naturals Orange
Herbion Naturals Orange Cough Drops
Hexahydrothymol
Hielo Ardiente
Honibe
 
Hot Ice Soothing Analgesic Gel
Huitomi Slimming Sports
Humphreys Bendito Alcoholado
I06-1216
I14-7371
IDI1_000820
Ice
Ice Cold Analgesic
Ice Cold Topical Analgesic Gel
Ice External Analgesic Leader
Ice Quake
Ice Quake Muscle Rub
Icy Cool Maximum Strength
Icy Hot
Icy Hot Back
Icy Hot Medicated
Icy Hot Medicated No Mess Applicator
Icy Hot Medicated Roll Large
Icy Hot Medicated Roll Medium
Icy Hot Medicated Roll, Large
Icy Hot Medicated Roll, Medium
Icy Hot Medicated, Advanced Relief
Icy Hot Medicated, Back
Icy Hot Medicated, XL
Icy Hot Naturals
Icy Hot Power Gel
Icy Hot Vanishing Scent
Icyhot Medicated
Imada Four Seasons Safe Analgesic Balm
Jakemans Blueberry
Jakemans Cherry
Jakemans Peppermint
K2 Cold Therapy
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
Kay Medic Menthol Pain Relief
Kool Comfort
Kool Comfort Pain Relieving Roll-on
Kpp Triple Action
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
La Jiao Feng Shi Gao
Lander Polar Ice
Leader Cough Drops Cherry Flavor
Leader Cough Drops Honey Lemon
Leader Cough Drops Menthol Flavor
Leader Extra Strength Medicated Pain Relief Patch
Leader Sugar Free Cough Drops Black Cherry
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
Linkus Lozenges Cough Suppressant/Oral Anesthetic
Low Sugar Cherry Flavor Fishermans Friend Menthol Cough Suppressant
Ludens Honey Lemon Throat Drops
Ludens Honey Licorice Throat Drops
Ludens Original Menthol Throat Drops
Lurosil
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Makesense Extra Strength Muscle Rub
Maxfit Freeze Gel
Maybelline New York Baby Lips Dr Rescue Medicated Balm
Medi First Plus Cherry Cough Drops
Medi-first Cherry Cough Drops
Medic Ice
Medicated Body Powder
Medicated Pain Relief
Mediflex
Medique Medikoff Drops
Medique Sugar Free Medikoff Drops
Meditowel PAIN RELIEF
Meijer Cherry Cough Drops
Meijer Honey Lemon Cough Drops
Meijer Menthol Cough Drops
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol Fresh Cough Suppressant
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Mentholatum Pain Relief Extra Strength
Mentholatum Sports Pain Relief Cold
Menthomenthol
Menthyl alcohol
Mineral Ice Pain Relieving
Miracle Foot Repair
Miracle Foot Repair Cream
Miracle Of Aloe Rub Roll On
Miracle Pain Cream
Moisture Therapy Anti-Itch
MolPort-000-849-729
MolPort-001-793-392
Moore Medical Cherry Cough Suppressant/anesthetic Drops
Moore Medical Sugar Free Black Cherry Cough Suppressant/anesthetic Drops
Moore Medical Sugar Free Menthol Cough Suppressant/anesthetic Drops
Mr Dudleys Topical Pain Relief
Muscle
Muscle Rub Ultra Strength Pain Relieving
Myo-breathe
Myorx Low Dose Pain Relieving
Myorx Pain Relieving
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Nan San Easy Flex Pain Relieving
Natural Cherry Honey Herb Throat Drops
Natural Herb cough drop
Natural Honey Herb Cough Suppressant Throat Drops
Natural Lemon Mint Herb Throat Drops
Natural Pain Relieving Lavender Breeze Cryogel
Natures Choice Cool Hot Ice
Natures Sunshine Products Everflex Topical Analgesic Pain Relief
Neoisomenthol
Nice Assorted
Nice Cherry
Nice Citrus
Nice Cool Mint
Nice Honey Lemon
Nice Menthol
No Pain More Gain
North Cough Drop
Numotizine
Olbas Lozenges Maximun Strength
Olbas Pastilles
Original Extra Strong All Natural Fishermans Friend Menthol Cough Suppressant
Ortho-nesic
Osmoflex
Oxyrub Pain Relief
Pain Relief Balmpreferred Plus Ph Preferred Plus Pharmacy
Pain Relief Therapy Patch
Pain Reliever
Pain Relieving
Pain Relieving Analgesic
Pain Relieving Patch
Pain Relieving Patch Ultra Strength
Pain Relieving Patch Ultra Strength ULTRA STRENGTH
Panitrol XR
Paraid Extra Strength Menthol Pain Relief Sleeve Knee Large Ankles Elbows
Patch Scherer Labs
Patch Walgreens
Peppermint camphor
Perfect Purity Hotice
Perfect Purity Medicated Foot Powder
Perform
Personal Care Extra Strength Cold Hot
Personal Care Ice Cold
Plaster MandAHerbalPlaster
Po Sum On Medicated
Polar Frost Cold
Power Relief
Preferred Plus Body Powder
Premier Value Medicated Foot Powder
Q Health Pain Relief Spray
Quickflex
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Raw Heat
Raw Ice
Reactice Reactivating Ice Baume
Red Lion Relief
Relief Pain Relieving Cream
Rexall Vanishing Scent Pain Relieving
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Screamin Menthol Toast
Sella Natural
Skin So Soft Bug Guard Plusitch Relief itch relief
Smith Bros Honey Lemon Cough Drops
Smith Bros Menthol Eucalyptus Cough Drops
Smith Bros Sugar-free Black Cherry Cough Drops
Sof Skin Icy Blue
Sofskin Ice Analgesic
Sombra Cool Therapy
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Stopain Cold Pain Relieving
Stopain Cold Professional Strength Pain Relieving
Stopain Extra Strength Pain Relieving
Sub-zero COOL PAIN RELIEVING
Sugar Free Cherry Fishermans Friend Menthol Cough Suppressant
Sugar Free Cherry Herb Throat Drops
Sugar Free Lemon Mint Herb Throat Drops
Sugar Free Mountain Herb Cough Suppressant Throat Drops
Sugar Free Original Swiss Herb Cough Suppressant Throat Drops
Sugar Free Refreshing Mint Fishermans Friend Menthol Cough Suppressant
Sugar Free Swiss Cherry Herb Throat Drops
The Medicine Shoppe Extra Strength Pain Relieving
The Original Natural Herb Cough Drops
Therafreeze
Theraid
Therapeutic Relief Preferred Plus Pharmacy
Theraplus Plus
Throat Coat
Tianhe Guben Yaoshen Tie Gao
Top Care Medicated
Topcare Medicated
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
Ultra Strength Stopain Pain Relieving
Us Favorite Cold Pain Relieving
Vaporizing Colds Rub
Vicks Vapodrops Cough Relief
Vitaminerals Inc. Cryogel Natural Pain Relieving
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
Walgreens Aloe Vera Cooling
Watermelon Frost Sore Throat
Wellpatch Backache Pain Relief
Xtracare Ice Cold Topical Analgesic Gel
Youngevity Invision CM
Yun Xiang Jing
ZINC01482164
Zhong Hua Jiu Patch
Zims Arnica Max
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol
13Neurotransmitter Agents14795
14
Carbon monoxide102281
Synonyms:
 
CO
Carbon monoxide
15Antimetabolites9454

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Efficacy of High-dose Intravenous Immunoglobulin Therapy for Hyperbilirubinemia Due Rh Hemolytic DiseaseCompletedNCT00288600Phase 4
2Use of a New Phototherapy Device (BBloo®) for the Treatment of Hyperbilirubinemia in the Newborn InfantRecruitingNCT02156050Phase 4
3Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase DeficiencyRecruitingNCT02594904Phase 4
4Efficacy and Safety of Stannsoporfin in NeonatesCompletedNCT02685137Phase 3
5Does Maternal Instruction Prevent Kernicterus in Nigeria?CompletedNCT02713464
6Determining Prevalence of Acute Bilirubin Encephalopathy in Developing CountriesCompletedNCT01754688
7Follow-up of Extreme Neonatal Hyperbilirubinemia in 5-10 Year Old Children: a Danish Population Based StudyCompletedNCT01599611
8Bilirubin Binding Capacity to Assess Bilirubin Load in Preterm InfantsRecruitingNCT02691156
9Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment.RecruitingNCT02224586
10Implementation of a Transcutaneous BilirubinometerRecruitingNCT01622699
11New Phototherapy Device to Treat Patients With Crigler-Najjar DiseaseActive, not recruitingNCT02356978

Search NIH Clinical Center for Kernicterus


Cochrane evidence based reviews: kernicterus

Genetic Tests for Kernicterus

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Anatomical Context for Kernicterus

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MalaCards organs/tissues related to Kernicterus:

33
Brain, Skin, Bone, Pituitary, Heart, Thyroid, T cells

Animal Models for Kernicterus or affiliated genes

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Publications for Kernicterus

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Articles related to Kernicterus:

(show top 50)    (show all 342)
idTitleAuthorsYear
1
Metal Ion Dependence of the Matrix Metalloproteinase-1 Mechanism. (26018933)
2015
2
TGF-I^1 up-regulates connexin43 expression: a potential mechanism for human trophoblast cell differentiation. (25560303)
2015
3
CD10 delineates a subset of human IL-4 producing follicular helper T cells involved in the survival of follicular lymphoma B cells. (25733581)
2015
4
WWOX suppresses prostate cancer cell progression through cyclin D1-mediated cell cycle arrest in the G1 phase. (25659037)
2015
5
Incretin effect and glucagon responses to oral and intravenous glucose in patients with maturity-onset diabetes of the young--type 2 and type 3. (24677712)
2014
6
Automatic retrieval of bone fracture knowledge using natural language processing. (23053906)
2013
7
Hospitalizations, costs, and mortality among infants with critical congenital heart disease: how important is timely detection? (24000201)
2013
8
Correction: Identification of Therapeutic Candidates for Chronic Lymphocytic Leukemia from a Library of Approved Drugs. (24223680)
2013
9
Undifferentiated small round cell sarcoma with t(4;19)(q35;q13.1) CIC-DUX4 fusion: a novel highly aggressive soft tissue tumor with distinctive histopathology. (23887164)
2013
10
Huge malignant solitary fibrous tumor of the pleura. (22566249)
2012
11
Therapeutic delivery of siRNA silencing HIF-1 alpha with micellar nanoparticles inhibits hypoxic tumor growth. (22924580)
2012
12
Detection of a novel FH whole gene deletion in the propositus leading to subsequent prenatal diagnosis in a sibship with fumarase deficiency. (22069215)
2012
13
Beneficial role of endogenous immunoglobulin subclasses and isotypes in septic shock. (23089676)
2012
14
A two-stage case-control association study between the tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population. (22342331)
2012
15
Stress and sleep disorder. (23319874)
2012
16
Regulation of synaptic vesicle recycling by complex formation between intersectin 1 and the clathrin adaptor complex AP2. (20160082)
2010
17
The histone demethylase UTX enables RB-dependent cell fate control. (20123895)
2010
18
ESX1 gene expression as a robust marker of residual spermatogenesis in azoospermic men. (20356899)
2010
19
Invasive aspergillosis osteomyelitis in children--a case report and review of the literature. (20512571)
2010
20
Asymmetrical interhemispheric fiber tracts in patients with hemimegalencephaly on diffusion tensor magnetic resonance imaging. (19783304)
2009
21
Effects of the GABA-reuptake inhibitor tiagabine on panic and anxiety in patients with panic disorder. (19924586)
2009
22
Locally advanced esophageal adenocarcinoma: current standards and molecular predictors of outcome. (18518766)
2008
23
Urotensin-II receptor antagonists: synthesis and SAR of N-cyclic azaalkyl benzamides. (18573659)
2008
24
Images in HIV/AIDS. HIV-associated lymphogranuloma venereum proctitis. (17396331)
2007
25
Parasitic peritoneal leiomyomatosis diagnosed 6 years after laparoscopic myomectomy with electric tissue morcellation: report of a case and review of the literature. (17980343)
2007
26
Typical clinical aspect of endomyocardial fibrosis. (16257072)
2006
27
Age-related change of bone biochemical markers and their relationships to mineral density in healthy Chinese men]. (17064589)
2006
28
Salpingo-oophorectomy and the risk of ovarian, fallopian tube, and peritoneal cancers in women with a BRCA1 or BRCA2 Mutation. (16835424)
2006
29
Immunohistochemical staining of cathepsins B, L and stefin A in human hypophysis and pituitary adenomas. (15816632)
2005
30
In-vitro and in-vivo effects of the CYP2C9*11 polymorphism on warfarin metabolism and dose. (15970795)
2005
31
Human tumor antigen MUC1 is chemotactic for immature dendritic cells and elicits maturation but does not promote Th1 type immunity. (16034102)
2005
32
Cycloxygenase-2 is expressed in vasculature of normal and ischemic adult human kidney and is colocalized with vascular prostaglandin E2 EP4 receptors. (15100359)
2004
33
Mucinous cystadenoma of the testis. (15201756)
2004
34
RUNX3 inhibits cell proliferation and induces apoptosis by reinstating transforming growth factor beta responsiveness in esophageal adenocarcinoma cells. (15300196)
2004
35
Mouse models for telomere and telomerase biology. (12858012)
2003
36
Radical curative efficacy of five-day regimen of primaquine for treatment of Plasmodium vivax malaria in India. (12435158)
2002
37
Height outcome in congenital adrenal hyperplasia caused by 21-hydroxylase deficiency: a meta-analysis. (11148508)
2001
38
Acetylsalicylic acid inhibits the pituitary response to exercise-related stress in humans. (11740295)
2001
39
Pheochromocytoma in a pregnant woman with multiple endocrine neoplasia type 2a. (11826768)
2001
40
Verrucous plaques on the face. North American blastomycosis. (10768656)
2000
41
Spatial regulation and activity modulation of plasmin by high affinity binding to the G domain of the alpha 3 subunit of laminin-5. (10956663)
2000
42
Evaluation of nonspecific immunity and plasma levels of interferon-gamma, interleukin-6 and tumor necrosis factor-alpha in preeclampsia. (10466079)
1999
43
Malone antegrade continence enema for adults with neurogenic bowel disease. (9751335)
1998
44
Cancer-associated retinopathy vs recoverin-associated retinopathy. (9727525)
1998
45
The membrane topology of GAT-1, a (Na+ + Cl-)-coupled gamma-aminobutyric acid transporter from rat brain. (8995422)
1997
46
Kindling increases brain levels of NAAG and seizures reduce activity of a NAAG-hydrolyzing enzyme, NAALADase. (1358101)
1992
47
Serum androsterone conjugates differentiate between acne and hirsutism in hyperandrogenic women. (1827073)
1991
48
Treatment of neurosyphilis. A comparison of penicillin regimens. (3616781)
1987
49
Midline cervical cleft. (4023095)
1985
50
Cataplexy in variant forms of Niemann-Pick disease. (7137965)
1982

Variations for Kernicterus

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Expression for genes affiliated with Kernicterus

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Search GEO for disease gene expression data for Kernicterus.

Pathways for genes affiliated with Kernicterus

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Pathways related to Kernicterus according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathwaysScoreTop Affiliating Genes
19.7UGT1A4, UGT1A9
2
Show member pathways
9.7UGT1A4, UGT1A9
39.6CYP3A4, UGT1A1
49.4ABCB1, CYP3A4
59.4ABCB1, CYP3A4
69.4ABCB1, CYP3A4
7
Show member pathways
9.4ABCB1, CYP3A4
89.4ABCB1, CYP3A4
99.1CYP3A4, GSTM1
10
Show member pathways
9.1ABCB1, CYP3A4, UGT1A1
119.1ABCB1, CYP3A4, UGT1A1
12
Show member pathways
9.1ABCB1, CYP3A4, UGT1A1
13
Show member pathways
8.8CYP3A4, UGT1A1, UGT1A4, UGT1A9
14
Show member pathways
8.8CYP3A4, UGT1A1, UGT1A4, UGT1A9
15
Show member pathways
8.7ABCB1, CYP3A4, UGT1A1, UGT1A9
16
Show member pathways
8.7G6PD, GCLC, GSTM1
17
Show member pathways
8.3ABCB1, CYP3A4, UGT1A1, UGT1A4, UGT1A9
18
Show member pathways
8.3ABCB1, CYP3A4, UGT1A1, UGT1A4, UGT1A9
19
Show member pathways
8.0CYP3A4, GSTM1, UGT1A1, UGT1A4, UGT1A9
20
Show member pathways
8.0CYP3A4, GSTM1, UGT1A1, UGT1A4, UGT1A9
21
Show member pathways
8.0CYP3A4, GSTM1, UGT1A1, UGT1A4, UGT1A9
22
Show member pathways
7.4CYP3A4, GCLC, GSTM1, UGT1A1, UGT1A4, UGT1A9
23
Show member pathways
5.8ABCB1, ALB, CYP3A4, G6PD, GCLC, GSTM1

GO Terms for genes affiliated with Kernicterus

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Biological processes related to Kernicterus according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1flavone metabolic processGO:005155210.2UGT1A1, UGT1A9
2cellular glucuronidationGO:005269510.2UGT1A1, UGT1A4
3porphyrin-containing compound metabolic processGO:00067789.9UGT1A1, UGT1A4
4negative regulation of glucuronosyltransferase activityGO:19042249.8UGT1A1, UGT1A4, UGT1A9
5response to organic substanceGO:00100339.8ALB, UGT1A1
6glutathione metabolic processGO:00067499.1G6PD, GCLC, GSTM1
7small molecule metabolic processGO:00442818.7G6PD, GCLC, UGT1A1, UGT1A4, UGT1A9
8metabolic processGO:00081528.5GSTM1, UGT1A1, UGT1A4, UGT1A9
9xenobiotic metabolic processGO:00068057.7CYP3A4, GCLC, GSTM1, UGT1A1, UGT1A4, UGT1A9

Molecular functions related to Kernicterus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1retinoic acid bindingGO:00019729.7UGT1A4, UGT1A9

Sources for Kernicterus

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet