MCID: KRN004
MIFTS: 46

Kernicterus malady

Rare diseases, Fetal diseases, Neuronal diseases, Infectious diseases categories

Aliases & Classifications for Kernicterus

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Aliases & Descriptions for Kernicterus:

Name: Kernicterus 8 42 10 44 48 2 61
Bilirubin Encephalopathy 8 42 48
Small Pox 42 48
Variola 42 48
 
Hyperbilirubinemic Encephalopathy 42
Kernicterus of Newborn Nos 8
Kernicterus of Newborn 8
Smallpox 61


Classifications:



External Ids:

Disease Ontology8 DOID:2382
MeSH33 D007647
NCIt39 C84799
Orphanet48 415675, 415286
ICD1025 P57

Summaries for Kernicterus

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Wikipedia:64 Kernicterus is a bilirubin-induced brain dysfunction. Bilirubin is a highly neurotoxic substance that... more...

MalaCards based summary: Kernicterus, also known as bilirubin encephalopathy, is related to glucose-6-phosphate dehydrogenase deficiency and blood group incompatibility. An important gene associated with Kernicterus is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Nicotine Pathway, Pharmacokinetics and Transport of vitamins, nucleosides, and related molecules. The compounds glucuronide and propofol have been mentioned in the context of this disorder. Affiliated tissues include brain, globus pallidus and liver.

Related Diseases for Kernicterus

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Diseases in the Kernicterus family:

Kernicterus Due to Isoimmunization

Diseases related to Kernicterus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1glucose-6-phosphate dehydrogenase deficiency31.2UGT1A1, G6PD
2blood group incompatibility31.1G6PD
3neonatal jaundice30.9UGT1A1, G6PD, RHD
4crigler-najjar syndrome, type ii30.8UGT1A1, UGT1A4
5crigler-najjar syndrome, type i30.5UGT1A1, UGT1A4
6hereditary spherocytosis29.7UGT1A1, SLC4A1, G6PD, RHD
7hemolytic anemia29.7G6PD, SLC4A1, RHD, UGT1A1
8variola minor11.0
9variola major10.9
10smallpox10.8
11monkeypox10.7
12vaccinia10.6
13kernicterus due to isoimmunization10.5
14gilbert syndrome10.5UGT1A1
15cowpox10.5
16hereditary elliptocytosis10.4SLC4A1
17thalassemias, alpha-10.4UGT1A1, G6PD
18cholelithiasis10.3UGT1A1, UGT1A6
19autoimmune hepatitis10.3UGT1A9, UGT1A1
20acute kidney failure10.3ALB, G6PD
21leukopenia10.2UGT1A1, ALB
22brain injury10.2
23cerebritis10.2
24autoimmune hemolytic anemia10.2G6PD, RHCE
25galactosemia10.2ALB, UGT1A1
26thalassemia10.2SLC4A1, UGT1A1, G6PD
27diarrhea10.2ALB, UGT1A1, UGT1A6
28hepatitis c10.2ALB, UGT1A9, UGT1A7
29bilirubin metabolic disorder10.2ALB, UGT1A7, UGT1A1, G6PD
30hepatitis10.1
31neuronitis10.1
32leprosy10.1
33tuberculoid leprosy10.1
34thalassemia, hispanic gamma-delta-beta10.0G6PD, RHD, UGT1A1
35hepatocellular carcinoma10.0ALB, UGT1A1, UGT1A9, UGT1A7
36sickle cell disease10.0UGT1A1, G6PD, RHD
37venezuelan equine encephalitis10.0
38encephalitis10.0
39congenital dyserythropoietic anemia10.0RHD, SLC4A1
40hyperhomocysteinemia10.0ALB, RHD
41metabolic acidosis10.0SLC4A1, ALB
42rh isoimmunization10.0RHCE, RHD
43hyperbilirubinemia, familial transient neonatal10.0
44cerebral palsy10.0
45rheumatic fever10.0
46central pontine myelinolysis10.0
47congenital hypothyroidism10.0
48aphasia10.0
49congenital hemolytic anemia10.0
50hypothyroidism10.0

Graphical network of the top 20 diseases related to Kernicterus:



Diseases related to kernicterus

Symptoms for Kernicterus

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Drugs & Therapeutics for Kernicterus

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Drug clinical trials:

Search ClinicalTrials for Kernicterus

Search NIH Clinical Center for Kernicterus

Genetic Tests for Kernicterus

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Anatomical Context for Kernicterus

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MalaCards organs/tissues related to Kernicterus:

31
Brain, Globus pallidus, Liver, Breast, Endothelial

Animal Models for Kernicterus or affiliated genes

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Publications for Kernicterus

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Articles related to Kernicterus:

(show top 50)    (show all 338)
idTitleAuthorsYear
1
Serum unbound bilirubin as a predictor for clinical kernicterus in extremely low birth weight infants at a late age in the neonatal intensive care unit. (25638486)
2015
2
Jaundice and kernicterus in the moderately preterm infant. (24182955)
2013
3
The Italian Registry of kernicterus and hyperbilirubinaemia. (22958040)
2012
4
Fatal kernicterus in a girl deficient in glucose-6-phosphate dehydrogenase: a paradigm of synergistic heterozygosity. (19324225)
2009
5
Unbound bilirubin: a better predictor of kernicterus? (18160727)
2008
6
Kernicterus in an adult dog. (17491082)
2007
7
Kernicterus associated with hereditary spherocytosis and UGT1A1 promoter polymorphism. (16735790)
2006
8
Magnetic resonance imaging of the brain in children with chronic kernicterus. (22266622)
2006
9
Hyperintense globus pallidus on T1-weighted MR imaging in acute kernicterus: is it common or rare? (15565320)
2005
10
Understanding severe hyperbilirubinemia and preventing kernicterus: adjuncts in the interpretation of neonatal serum bilirubin. (15936300)
2005
11
Urgent clinical need for accurate and precise bilirubin measurements in the United States to prevent kernicterus. (14726464)
2004
12
Research on prevention of bilirubin-induced brain injury and kernicterus: National Institute of Child Health and Human Development conference executive summary. 2003. (15231933)
2004
13
Cost-effectiveness of strategies that are intended to prevent kernicterus in newborn infants. (15466085)
2004
14
Kernicterus and G6PD deficiency--a case series from Oman. (12729287)
2003
15
Breast-feeding, neonatal jaundice and kernicterus. (12208098)
2002
16
System-based approach to management of neonatal jaundice and prevention of kernicterus. (12006952)
2002
17
Preterm infants with athetoid cerebral palsy: kernicterus? (11207234)
2001
18
From the Centers for Disease Control and Prevention. Kernicterus in full-term infants--United States, 1994-1998. (11474907)
2001
19
Risk factors for kernicterus in term babies with non-hemolytic jaundice. (11463962)
2001
20
Kernicterus threatens healthy newborns. (11424865)
2001
21
Kernicterus in a full-term infant: the need for increased vigilance. (7724333)
1995
22
Kernicterus in preterm infants; lest we forget (to turn on the lights) (1408550)
1992
23
Assessing the risk of kernicterus using nuclear magnetic resonance. (2369802)
1990
24
Auditory brainstem response in patients with a history of kernicterus. (3272525)
1988
25
Kernicterus in the premature neonate. (3333255)
1987
26
Neonatal bilirubin toxicity. A review of kernicterus and the implications of drug-induced bilirubin displacement. (3304769)
1987
27
Value and limitations of bilirubin binding capacity in predicting the development of kernicterus. (6466218)
1984
28
Kernicterus at low levels of serum bilirubin: the impact of bilirubin albumin-binding capacity. A 10-year retrospective survey. (7199940)
1982
29
Kernicterus: effect on choline acetyltransferase, glutamic acid decarboxylase and tyrosine hydroxylase activities in the brain of the Gunn rat. (6105009)
1980
30
Singapore kernicterus. (262490)
1979
31
The pathochemistry of kernicterus. (43803)
1979
32
Absence of kernicterus in low-birth weight infants from 1971 through 1976: comparison with findings in 1966 and 1967. (714577)
1978
33
Breakdown of blood/brain barrier in kernicterus. (67529)
1977
34
An electron microscopic and radioautographic study on experimental kernicterus. I. Bilirubin transport via astroglia. (5815579)
1969
35
Serum albumin reserve PSP dye binding capacity in infants with kernicterus. (6067403)
1967
36
Risk of kernicterus in newborn infants with a high level of conjugated bilirubin. (6007580)
1966
37
KERNICTERUS IN NEWBORN RABBITS. (14266216)
1965
38
PREVENTION OF CEREBRAL DAMAGE (KERNICTERUS) FROM FOETO-MATERNAL INCOMPATIBILITY; ANTENATAL ASPECTS. (14062989)
1963
39
Kernicterus in premature infants associated with low concentrations of bilirubin in the plasma. (13553575)
1958
40
Clinical kernicterus and congenital hypothyroidism. (13493800)
1958
41
Congenital hemolytic anemia in the newborn; relationship to kernicterus. (13478296)
1957
42
Experimental studies on the pathogenesis of kernicterus. (13484304)
1957
43
Congenital cirrhosis of the liver with kernicterus; report of two cases in siblings with a discussion of the relationship to so-called neonatal hepatitis and to iso-immunization disease. (13268609)
1955
44
Prevention of death and crippling from kernicterus in hemolytic disease of the newborn. (13221977)
1954
45
Cerebrospinal fluid bilirubin in the neonatal period with special reference to the development of kernicterus; preliminary report. (13217811)
1954
46
The mechanism of production of kernicterus. (13000553)
1952
47
Kernicterus. (14819084)
1951
48
Central nervous system complications associated with kernicterus. (21011225)
1946
49
Pathogenesis of Kernicterus. (17800122)
1946
50
Case of Kernicterus. (19992043)
1939

Variations for Kernicterus

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Expression for genes affiliated with Kernicterus

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Search GEO for disease gene expression data for Kernicterus.

Pathways for genes affiliated with Kernicterus

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Pathways related to Kernicterus according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Nicotine metabolism36
9.8UGT1A4, UGT1A9
2
Show member pathways
9.8SLC35A2, ALB
3
Show member pathways
bupropion degradation36
methylglyoxal degradation III36
nicotine degradation III36
nicotine degradation IV36
9.8UGT1A4, UGT1A10
4
Show member pathways
AhR pathway36
9.8UGT1A1, UGT1A6
5
Show member pathways
Codeine and morphine metabolism36
9.7UGT1A1, UGT1A8
69.6UGT1A8, UGT1A10
7
Show member pathways
9.6UGT1A1, UGT1A10, UGT1A9
89.5UGT1A9, UGT1A6, UGT1A1
9
Show member pathways
8.6UGT1A1, UGT1A8, UGT1A9, UGT1A4, UGT1A6
108.6UGT1A8, UGT1A1, UGT1A6, UGT1A9, UGT1A4
118.5UGT1A8, UGT1A6, UGT1A9, UGT1A10, UGT1A4
12
Show member pathways
7.9UGT1A1, UGT1A7, UGT1A4, UGT1A8, UGT1A6, UGT1A9
13
Show member pathways
7.6UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A5, UGT1A6
14
Show member pathways
7.6UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A5, UGT1A6
15
Show member pathways
7.6UGT1A8, UGT1A5, UGT1A9, UGT1A10, UGT1A4, UGT1A7
16
Show member pathways
tetrapyrrole biosynthesis36
heme degradation36
Heme Biosynthesis36
heme biosynthesis36
heme biosynthesis from uroporphyrinogen-III I36
7.6UGT1A7, UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9
17
Show member pathways
7.6UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A4
18
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism36
7.6UGT1A4, UGT1A7, UGT1A10, UGT1A9, UGT1A5, UGT1A6
19
Show member pathways
6.6ALB, UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9

Compounds for genes affiliated with Kernicterus

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
See all sources

Compounds related to Kernicterus according to GeneCards Suite gene sharing:

(show top 50)    (show all 167)
idCompoundScoreTop Affiliating Genes
1glucuronide448.7UGT1A1, UGT1A6, UGT1A9, UGT1A10, UGT1A4, UGT1A7
2propofol44 50 1110.3ALB, UGT1A1, UGT1A8, UGT1A6, UGT1A9, UGT1A10
3cotinine44 249.3UGT1A4, UGT1A7, UGT1A10, UGT1A1, UGT1A8, UGT1A6
4n-hydroxy phip448.2UGT1A1, UGT1A8, UGT1A6, UGT1A9, UGT1A10, UGT1A4
5ethyl glucuronide44 249.2UGT1A1, UGT1A8, UGT1A6, UGT1A9, UGT1A10, UGT1A4
6Cholesterol glucuronide248.1UGT1A9, UGT1A10, UGT1A4, UGT1A7, UGT1A5, UGT1A1
7Epinephrine glucuronide248.1UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A4
8Estriol 3-sulfate 16-glucuronide248.1UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
9Cholic acid glucuronide248.1UGT1A7, UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9
10Estriol-17-glucuronide248.1UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A4, UGT1A7
11Estriol-3-glucuronide248.1UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
12Estriol-16-Glucuronide248.1UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
136-Hydroxy-5-methoxyindole glucuronide248.1UGT1A5, UGT1A9, UGT1A10, UGT1A4, UGT1A7, UGT1A1
14Benzoyl glucuronide (Benzoic acid)248.1UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
15Androsterone248.0UGT1A7, UGT1A4, UGT1A1, UGT1A8, UGT1A6, UGT1A5
16Cholestane-3,7,12,25-tetrol-3-glucuronide248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
17Bilirubin glucuronide248.0UGT1A7, UGT1A4, UGT1A1, UGT1A8, UGT1A6, UGT1A5
18Retinoyl b-glucuronide248.0UGT1A7, UGT1A4, UGT1A1, UGT1A8, UGT1A6, UGT1A5
19Testosterone glucuronide248.0UGT1A9, UGT1A10, UGT1A4, UGT1A7, UGT1A5, UGT1A6
20Testosterone sulfate248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
21Retinyl beta-glucuronide248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
22Tetrahydroaldosterone-3-glucuronide248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
23Thyroxine glucuronide248.0UGT1A10, UGT1A4, UGT1A7, UGT1A9, UGT1A5, UGT1A1
24trans-3-Hydroxycotinine glucuronide248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
25Etiocholanolone glucuronide248.0UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A4, UGT1A7
26Glycochenodeoxycholic acid 3-glucuronide248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
27Estrone glucuronide248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
28Pregnanediol-3-glucuronide248.0UGT1A5, UGT1A9, UGT1A10, UGT1A4, UGT1A7, UGT1A6
29Phenethylamine glucuronide248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
30androsterone glucuronide44 249.0UGT1A5, UGT1A9, UGT1A10, UGT1A4, UGT1A7, UGT1A6
31estriol28 24 1110.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
323-alpha-androstanediol glucuronide44 249.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
33bilirubin diglucuronide44 249.0UGT1A10, UGT1A4, UGT1A7, UGT1A9, UGT1A5, UGT1A1
34(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
35valproic acid44 50 24 1110.9UGT1A9, UGT1A10, UGT1A4, UGT1A7, UGT1A6, UGT1A8
36codeine44 28 50 24 1111.9UGT1A7, UGT1A4, UGT1A1, UGT1A8, UGT1A6, UGT1A5
372-Methoxyestrone247.9UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A4, UGT1A7
382-Methoxyestrone 3-glucuronide247.9UGT1A7, UGT1A4, UGT1A10, UGT1A1, UGT1A8, UGT1A6
392-Phenylethanol glucuronide247.8UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
4025-Hydroxyvitamin D2 25-(beta-glucuronide)247.8UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
416-Dehydrotestosterone glucuronide247.8UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
42Bilirubin247.8ALB, UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9
4325-Hydroxyvitamin D2-25-glucuronide247.8UGT1A7, UGT1A4, UGT1A1, UGT1A8, UGT1A6, UGT1A5
441-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid247.7UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
451-Salicylate glucuronide247.7UGT1A10, UGT1A4, UGT1A7, UGT1A9, UGT1A5, UGT1A1
46estrone44 28 24 1110.7ALB, UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9
4717-beta-estradiol glucuronide247.6UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
482-Methoxy-estradiol-17b 3-glucuronide247.6UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
4917-beta-estradiol-3-glucuronide247.5UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
5017-hydroxyandrostane-3-glucuronide247.3UGT1A4, UGT1A7, UGT1A10, UGT1A9, UGT1A1, UGT1A8

GO Terms for genes affiliated with Kernicterus

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Cellular components related to Kernicterus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:00057897.3UGT1A1, UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A5
2integral component of membraneGO:00160216.9UGT1A4, UGT1A10, UGT1A9, UGT1A5, UGT1A6, UGT1A8

Biological processes related to Kernicterus according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1coumarin metabolic processGO:00098049.6UGT1A8, UGT1A7
2negative regulation of fatty acid metabolic processGO:00459229.4UGT1A8, UGT1A9, UGT1A7
3negative regulation of steroid metabolic processGO:00459399.4UGT1A1, UGT1A8
4negative regulation of cellular glucuronidationGO:020010309.3UGT1A7, UGT1A9, UGT1A8, UGT1A1
5xenobiotic glucuronidationGO:00526979.3UGT1A7, UGT1A9, UGT1A8, UGT1A1
6flavonoid glucuronidationGO:00526969.3UGT1A7, UGT1A9, UGT1A8, UGT1A1
7cellular glucuronidationGO:00526959.3UGT1A4, UGT1A10, UGT1A6, UGT1A1
8retinoic acid metabolic processGO:00425739.2UGT1A1, UGT1A8, UGT1A9, UGT1A7
9drug metabolic processGO:00171449.2UGT1A7, UGT1A9, UGT1A8, UGT1A1
10negative regulation of catalytic activityGO:00430869.1UGT1A7, UGT1A9, UGT1A8, UGT1A1
11flavone metabolic processGO:00515529.0UGT1A1, UGT1A8, UGT1A9, UGT1A10, UGT1A7
12xenobiotic metabolic processGO:00068059.0UGT1A4, UGT1A9, UGT1A6, UGT1A1
13small molecule metabolic processGO:00442818.1UGT1A4, UGT1A9, UGT1A6, UGT1A1, G6PD, ALB

Molecular functions related to Kernicterus according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1protein kinase C bindingGO:00050809.8UGT1A10, UGT1A7
2fatty acid bindingGO:00055049.6ALB, UGT1A8
3drug bindingGO:00081449.4ALB, UGT1A8, UGT1A7
4steroid bindingGO:00054969.4UGT1A1, UGT1A8
5enzyme inhibitor activityGO:00048579.2UGT1A7, UGT1A9, UGT1A8, UGT1A1
6ammonium transmembrane transporter activityGO:00085199.0RHD, RHCE
7retinoic acid bindingGO:00019728.1UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A6, UGT1A8
8protein heterodimerization activityGO:00469828.1UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A6, UGT1A8
9glucuronosyltransferase activityGO:00150207.9UGT1A1, UGT1A7, UGT1A8, UGT1A6, UGT1A5, UGT1A9
10enzyme bindingGO:00198997.8UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A6, UGT1A8
11protein homodimerization activityGO:00428037.3UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A6, UGT1A8

Sources for Kernicterus

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet