MCID: KRN004
MIFTS: 47

Kernicterus malady

Summaries for Kernicterus

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63Wikipedia, 32MalaCards
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Wikipedia:63 Kernicterus is a bilirubin-induced brain dysfunction. Bilirubin is a highly neurotoxic substance that... more...

MalaCards: Kernicterus, also known as bilirubin encephalopathy, is related to neonatal jaundice and crigler-najjar syndrome. An important gene associated with Kernicterus is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Ifosfamide Pathway, Pharmacokinetics and Arylamine metabolism. The compounds n-acetylbenzidine and sn38 glucuronide have been mentioned in the context of this disorder. Affiliated tissues include brain, globus pallidus and liver.

Aliases & Classifications for Kernicterus

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

kernicterus 8 42 10 44 60
bilirubin encephalopathy 8 42
hyperbilirubinemic encephalopathy 42
kernicterus of newborn nos 8
kernicterus of newborn 8


External Ids:

Disease Ontology8 DOID:2382
MeSH34 D007647
NCIt39 C84799

Related Diseases for Kernicterus

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17GeneCards, 18GeneDecks
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Diseases in the Kernicterus Due to Isoimmunization family:

kernicterus

Diseases related to Kernicterus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1neonatal jaundice30.7RHD, UGT1A1, G6PD
2crigler-najjar syndrome30.3UGT1A1, UGT1A4
3hepatitis30.1UGT1A1
4crigler najjar syndrome, type 229.8UGT1A1, UGT1A4
5liver cirrhosis29.8ALB
6gilbert syndrome29.8G6PD, UGT1A4, UGT1A1, UGT1A7
7hereditary spherocytosis29.8G6PD, UGT1A1, RHD
8hemolytic anemia29.8RHD, UGT1A1, G6PD
9kernicterus due to isoimmunization10.5
10cerebritis10.2
11blood group incompatibility10.2
12neuronitis10.1
13hepatitis a10.1
14cerebral palsy athetoid10.1
15galactosemia10.0ALB
16glucosephosphate dehydrogenase deficiency10.0G6PD, UGT1A1
17cholelithiasis10.0UGT1A6, UGT1A1
18senile cataract10.0G6PD
19alpha thalassemia10.0UGT1A1, G6PD
20neutropenia10.0UGT1A1, UGT1A6
21colon cancer10.0UGT1A10, UGT1A1
22diarrhea10.0UGT1A6, UGT1A1, ALB
23lung cancer10.0ALB
24bilirubin metabolic disorder10.0G6PD, UGT1A1, UGT1A7, ALB
25hereditary elliptocytosis10.0G6PD, RHD
26beta thalassemia10.0RHD, UGT1A1, G6PD
27sickle cell disease10.0G6PD, UGT1A1, RHD
28hyperhomocysteinemia10.0RHD, ALB
29autoimmune hemolytic anemia10.0RHCE, G6PD
30hepatitis c10.0ALB, UGT1A7, UGT1A9
31rh isoimmunization10.0RHD, RHCE
32deficiency anemia10.0ALB, RHCE, RHD, G6PD
33rheumatic fever9.9
34congenital hypothyroidism9.9
35central pontine myelinolysis9.9
36adult syndrome9.9
37aphasia9.9
38cerebral palsy9.9
39congenital hemolytic anemia9.9
40hypothyroidism9.9
41liver disease9.9
42viral hepatitis9.9
43lucey-driscoll syndrome9.9

Graphical network of the top 20 diseases related to Kernicterus:



Diseases related to kernicterus

Clinical Features for Kernicterus

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Drugs & Therapeutics for Kernicterus

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Kernicterus

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Anatomical Context for Kernicterus

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32MalaCards
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MalaCards organs/tissues related to Kernicterus:

32
Brain, Globus pallidus, Liver, Breast, Endothelial

Animal Models for Kernicterus or affiliated genes

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Publications for Kernicterus

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50PubMed
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Articles related to Kernicterus:

(show top 50)    (show all 333)
idTitleAuthorsYear
1
Low bilirubin kernicterus with sepsis and hypoalbuminaemia. (23616313)
2013
2
Neonatal death suspected to be from sepsis was found to be kernicterus with G6PD deficiency. (24218468)
2013
3
MRI findings in a dog with kernicterus. (23690488)
2013
4
Changes in the globus pallidus in chronic kernicterus. (21887193)
2009
5
A proposal to prevent severe neonatal hyperbilirubinemia and kernicterus. (19177062)
2009
6
Neonatal hyperbilirubinemia and kernicterus - not gone but sometimes forgotten. (19833460)
2009
7
Glucose-6-phosphate dehydrogenase deficiency and kernicterus of South-East anatolia. (17483701)
2007
8
Management of hyperbilirubinemia and prevention of kernicterus in 20 patients with Crigler-Najjar disease. (16435131)
2006
9
NICHD Conference on Kernicterus: Research on Prevention of Bilirubin-Induced Brain Injury and Kernicterus: Bench-to-Bedside--Diagnostic Methods and Prevention and Treatment Strategies. (15129227)
2004
10
Kernicterus: epidemiological strategies for its prevention through systems-based approaches. (15254556)
2004
11
How to avoid kernicterus. (12584552)
2003
12
Breast-feeding, neonatal jaundice and kernicterus. (12208098)
2002
13
Kernicterus: an international perspective. (12208094)
2002
14
Preventing kernicterus: almost there. (12006947)
2002
15
Neonatal jaundice and kernicterus. (11533348)
2001
16
Kernicterus in a full-term infant: the need for increased vigilance. (7724333)
1995
17
Clinical study on the prevention of kernicterus caused by hereditary glucose-6-phosphate dehydrogenase deficiency]. (1332814)
1992
18
Kernicterus in preterm newborns: past, present, and future. (1408544)
1992
19
Management of neonatal hyperbilirubinaemia and prevention of kernicterus. (1379158)
1992
20
A physiologic approach to identifying neonates at risk for kernicterus. (2376785)
1990
21
Controversial topics in kernicterus. (3061711)
1988
22
Neonatal bilirubin toxicity. A review of kernicterus and the implications of drug-induced bilirubin displacement. (3304769)
1987
23
Kernicterus research and the basic sciences: a prospect for future development. (3797160)
1987
24
Crigler-Najjar syndrome type II with kernicterus. (3443510)
1987
25
Kernicterus in term infants. (3867347)
1985
26
The neuropathology of kernicterus in the premature neonate: diagnostic problems. (6693927)
1984
27
Kernicterus at low levels of serum bilirubin: the impact of bilirubin albumin-binding capacity. A 10-year retrospective survey. (7199940)
1982
28
A prospective study of free bilirubin and other risk factors in the development of kernicterus in premature infants. (7063282)
1982
29
Kernicterus: effect on choline acetyltransferase, glutamic acid decarboxylase and tyrosine hydroxylase activities in the brain of the Gunn rat. (6105009)
1980
30
The association of kernicterus with bacterial infection in the newborn. (7355031)
1980
31
Prevention of kernicterus, based on recent progress in bilirubin chemistry. (19921)
1977
32
Kernicterus in a newborn female with G-6-PD deficiency. (978340)
1976
33
Bilirubin binding, free fatty acids and a new concept for the pathogenesis of kernicterus. (953186)
1976
34
Bilirubin interaction with ganglioside: possible mechanism in kernicterus. (241962)
1975
35
Supersaturation with bilirubin followed by colloid formation and disposition, with a hypothesis on the etiology of kernicterus. (21488414)
1972
36
Studies in kernicterus. 3. The saturation of serum proteins with bilirubin during neonatal life and its relationship to brain damage at five years. (5410148)
1970
37
Nuclear jaundice (kernicterus) in a newborn kitten. (4920068)
1970
38
Kernicterus. Development of an experimental model using bilirubin 14C. (5949266)
1966
39
The chemical basis of kernicterus. (13684197)
1960
40
Studies in kernicterus. I. The protein binding of bilirubin. (13654518)
1959
41
Liver-immaturity and treatment of kernicterus of the premature baby. (13574885)
1958
42
Congenital hemolytic anemia in the newborn; relationship to kernicterus. (13478296)
1957
43
Kernicterus; further observations on the toxicity of heme pigments. (13322535)
1956
44
Prevention of kernicterus; management of erythroblastosis fetalis according to current knowledge. (13174377)
1954
45
The mechanism of production of kernicterus. (13000553)
1952
46
The occurrence of kernicterus in an autopsy material. (13030251)
1952
47
Erythroblastosis fetalis. VI. Prevention of kernicterus. (14777158)
1950
48
Encephalopathy (kernicterus) of erythroblastosis fetalis; serologic diagnosis and pathogenesis. (20256259)
1947
49
Pathogenesis of Kernicterus. (17800122)
1946
50
Case of Kernicterus. (19992043)
1939

Genetic Variations for Kernicterus

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Expression for genes affiliated with Kernicterus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Kernicterus

Search GEO for disease gene expression data for Kernicterus.

Pathways for genes affiliated with Kernicterus

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Sources:
49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 29KEGG
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Pathways related to Kernicterus according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.0UGT1A1, UGT1A9
210.0UGT1A4, UGT1A9
3
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10.0UGT1A4, UGT1A9
4
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9.9UGT1A4, UGT1A10
5
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9.9UGT1A1, UGT1A8
6
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9.6UGT1A10, UGT1A6, UGT1A9
79.5UGT1A8, UGT1A10, UGT1A3
8
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9.5UGT1A9, UGT1A1, UGT1A10, UGT1A3
9
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9.4UGT1A1, UGT1A6, UGT1A4, UGT1A9
10
Hide members
8.8UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A3
118.7UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A10, UGT1A3
12
Hide members
8.6UGT1A9, UGT1A4, UGT1A8, UGT1A1, UGT1A10, UGT2B28
13
Acetaminophen metabolism
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8.5UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
14
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8.2UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
15
Hide members
7.3UGT1A1, UGT1A5, UGT1A10, UGT2B28, UGT2A3, UGT1A7
16
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7.3UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
17
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7.3UGT1A6, UGT1A1, UGT1A5, UGT1A10, UGT2B28, UGT2A3
18
Hide members
7.1G6PD, UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1

Compounds for genes affiliated with Kernicterus

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Kernicterus according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1n-acetylbenzidine4410.1UGT1A1, UGT1A4, UGT1A9
2sn38 glucuronide4410.0UGT1A9, UGT1A1, UGT1A7
3acetaminophen glucuronide44 2411.0UGT1A1, UGT1A6, UGT1A9
4Ezogabine 119.9UGT1A3, UGT1A1, UGT1A4, UGT1A9
54-methylumbelliferone449.9UGT1A9, UGT1A6, UGT1A1
6flurbiprofen44 28 49 1112.9ALB, UGT1A3, UGT1A1, UGT1A9
71-naphthol449.8UGT1A9, UGT1A6, UGT1A1
8benzidine449.8UGT1A1, UGT1A6, UGT1A4, UGT1A9
9etodolac44 1110.8UGT1A9, UGT1A10, UGT1A3, ALB
10lamotrigine44 1110.7UGT1A4, UGT1A6, UGT1A1, UGT1A3
11phenol44 2410.7G6PD, UGT1A9, UGT1A6, UGT1A1
12trifluoperazine44 28 1111.7UGT1A1, UGT1A6, UGT1A4, UGT1A9
13udp glucuronic acid449.6UGT1A8, UGT1A6, UGT1A1, UGT1A10
14ibuprofen44 28 49 11 2413.6ALB, UGT1A3, UGT1A1, UGT1A9
15sulfamethoxazole44 49 1111.6ALB, UGT1A9, G6PD
16p-nitrophenol44 1110.5UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A3
17mycophenolate mofetil44 49 1111.5ALB, UGT1A10, UGT1A1, UGT1A8, UGT1A9
18irinotecan44 49 1111.5UGT1A9, UGT1A6, UGT1A1, UGT1A7, ALB
19benzo(a)pyrene449.4UGT1A9, UGT1A6, UGT1A1, UGT1A7
20amine449.4UGT1A3, UGT1A7, UGT1A1, UGT1A4
21uridine44 11 2411.4UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A7
22losartan44 49 28 1112.4UGT1A1, UGT1A10, UGT1A3, ALB
23diclofenac44 28 49 1112.3UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A3, ALB
24mycophenolic acid44 49 1111.2UGT1A9, UGT1A8, UGT1A1, UGT1A10, UGT1A7, ALB
25tamoxifen44 49 28 1112.2G6PD, UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A3
26morphine44 49 28 1112.1UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A3
27acetaminophen44 2 49 11 2413.0G6PD, UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A10
28glucuronide449.0UGT1A3, UGT1A7, UGT1A10, UGT1A9, UGT1A4, UGT1A6
29uridine diphosphate448.9UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A10, UGT1A7
30n-hydroxy phip448.9UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
31troglitazone44 28 59 1111.9UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
32propofol44 49 1110.7UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
33ethyl glucuronide44 249.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
34cotinine44 249.6UGT1A3, UGT1A7, UGT1A10, UGT1A9, UGT1A4, UGT1A8
35imipramine44 49 28 11 2412.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
36nicotine44 49 28 1111.5UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
37valproic acid44 49 11 2411.4UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
38(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)247.7UGT1A8, UGT1A6, UGT1A1, UGT1A5, UGT1A10, UGT2B28
39bilirubin diglucuronide44 248.7UGT1A6, UGT1A1, UGT1A5, UGT1A10, UGT2B28, UGT2A3
40aldosterone 18-glucuronide44 248.7UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
41codeine44 49 28 11 2411.7UGT1A6, UGT1A1, UGT1A5, UGT1A10, UGT2B28, UGT2A3
42etiocholanolone44 248.7UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
432-methoxyestradiol44 59 249.7UGT1A1, UGT1A5, UGT1A10, UGT2B28, UGT2A3, UGT1A7
44androsterone glucuronide44 248.7UGT1A1, UGT1A5, UGT1A10, UGT2B28, UGT2A3, UGT1A7
453-alpha-androstanediol glucuronide44 248.7UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
46estriol28 11 249.7UGT1A5, UGT1A10, UGT2B28, UGT2A3, UGT1A7, UGT1A3
47retinoic acid44 248.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
48estrone44 28 11 2410.5UGT1A5, UGT1A10, UGT2B28, UGT2A3, UGT1A7, UGT1A3
49estradiol44 11 249.5UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
50testosterone44 59 11 2410.3UGT1A8, UGT1A6, UGT1A1, UGT1A5, UGT1A10, UGT2B28

GO Terms for genes affiliated with Kernicterus

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16Gene Ontology
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Cellular components related to Kernicterus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular membrane-bounded organelleGO:0432319.1UGT1A5, UGT1A6, UGT1A8, UGT1A9, G6PD
2endoplasmic reticulum membraneGO:0057897.6UGT1A3, UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1
3integral to membraneGO:0160215.5UGT1A5, UGT1A6, UGT1A8, UGT3A1, UGT1A4, UGT1A9

Biological processes related to Kernicterus according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1coumarin metabolic processGO:0098049.8UGT1A7, UGT1A8
2negative regulation of steroid metabolic processGO:0459399.6UGT1A1, UGT1A8
3negative regulation of fatty acid metabolic processGO:0459229.5UGT1A9, UGT1A8, UGT1A7
4negative regulation of catalytic activityGO:0430869.4UGT1A7, UGT1A1, UGT1A8, UGT1A9
5flavonoid glucuronidationGO:0526969.3UGT1A9, UGT1A8, UGT1A1, UGT1A7, UGT1A3
6xenobiotic glucuronidationGO:0526979.3UGT1A3, UGT1A7, UGT1A1, UGT1A8, UGT1A9
7drug metabolic processGO:0171449.3UGT1A7, UGT1A1, UGT1A8, UGT1A9
8flavone metabolic processGO:0515529.2UGT1A9, UGT1A8, UGT1A1, UGT1A10, UGT1A7
9retinoic acid metabolic processGO:0425739.2UGT1A9, UGT1A8, UGT1A1, UGT1A7, UGT1A3
10cellular glucuronidationGO:0526959.2UGT1A4, UGT1A6, UGT1A1, UGT1A10, UGT2A3, UGT2A1
11xenobiotic metabolic processGO:0068059.1UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A5, UGT2B28
12metabolic processGO:0081528.9UGT2A1, UGT1A9, UGT1A6, UGT1A5, UGT1A10, UGT2B28

Molecular functions related to Kernicterus according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1fatty acid bindingGO:0055049.9ALB, UGT1A8
2ammonium transmembrane transporter activityGO:0085199.4RHD, RHCE
3enzyme inhibitor activityGO:0048579.4UGT1A7, UGT1A1, UGT1A8, UGT1A9
4drug bindingGO:0081449.3ALB, UGT1A7, UGT1A8
5UDP-glycosyltransferase activityGO:0081948.8UGT3A1, UGT3A2, UGT1A3
6retinoic acid bindingGO:0019728.4UGT1A3, UGT1A7, UGT1A10, UGT1A1, UGT1A6, UGT1A8
7protein heterodimerization activityGO:0469828.3UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
8enzyme bindingGO:0198998.2UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
9protein homodimerization activityGO:0428038.1G6PD, UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1
10glucuronosyltransferase activityGO:0150206.0UGT2A1, UGT1A9, UGT1A4, UGT3A1, UGT1A8, UGT1A3

Products for genes affiliated with Kernicterus

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  • Antibodies
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Sources for Kernicterus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet