MCID: KRN004
MIFTS: 46

Kernicterus malady

Summaries for Kernicterus

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Kernicterus is a bilirubin-induced brain dysfunction. Bilirubin is a highly neurotoxic substance that... more...

MalaCards: Kernicterus, also known as bilirubin encephalopathy, is related to crigler-najjar syndrome and hepatitis c. An important gene associated with Kernicterus is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Ifosfamide Pathway, Pharmacokinetics and Arylamine metabolism. The compounds n-acetylbenzidine and sn38 glucuronide have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and breast.

Aliases & Classifications for Kernicterus

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

kernicterus 8 43 10 45 61
bilirubin encephalopathy 8 43
hyperbilirubinemic encephalopathy 43
kernicterus of newborn nos 8
kernicterus of newborn 8


External Ids:

Disease Ontology8 DOID:2382
MeSH35 D007647
NCIt40 C84799

Related Diseases for Kernicterus

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Kernicterus family:

kernicterus due to isoimmunization

Diseases related to Kernicterus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1crigler-najjar syndrome30.3UGT1A1, UGT1A4
2hepatitis c30.1ALB, UGT1A7, UGT1A9
3crigler najjar syndrome, type 229.9UGT1A1, UGT1A4
4gilbert syndrome29.9G6PD, UGT1A4, UGT1A1, UGT1A7
5hereditary spherocytosis29.9G6PD, UGT1A1, RHD
6fetal erythroblastosis10.4
7kernicterus due to isoimmunization10.3
8n syndrome10.3
9blood group incompatibility10.2
10brain injury10.2
11congenital nonhemolytic jaundice10.1
12sepsis10.1
13hepatitis10.0UGT1A1
14galactosemia10.0ALB
15thalassemia10.0UGT1A1, G6PD
16glucosephosphate dehydrogenase deficiency10.0G6PD, UGT1A1
17cholelithiasis10.0UGT1A6, UGT1A1
18senile cataract10.0G6PD
19liver cirrhosis10.0ALB
20alpha thalassemia10.0UGT1A1, G6PD
21neutropenia10.0UGT1A1, UGT1A6
22colon cancer10.0UGT1A10, UGT1A1
23diarrhea10.0UGT1A6, UGT1A1, ALB
24lung cancer10.0ALB
25bilirubin metabolic disorder10.0G6PD, UGT1A1, UGT1A7, ALB
26hereditary elliptocytosis10.0G6PD, RHD
27neonatal jaundice10.0RHD, UGT1A1, G6PD
28beta thalassemia10.0RHD, UGT1A1, G6PD
29hemolytic anemia10.0RHD, UGT1A1, G6PD
30sickle cell disease10.0G6PD, UGT1A1, RHD
31hyperhomocysteinemia10.0RHD, ALB
32autoimmune hemolytic anemia10.0RHCE, G6PD
33rh isoimmunization10.0RHD, RHCE
34deficiency anemia10.0ALB, RHCE, RHD, G6PD
35rheumatic fever9.9
36congenital hypothyroidism9.9
37central pontine myelinolysis9.9
38hepatitis d9.9
39adult syndrome9.9
40aphasia9.9
41viral hepatitis9.9
42char syndrome9.9
43cerebral palsy athetoid9.9
44athetosis9.9
45lucey-driscoll syndrome9.9
46anoxia9.9

Graphical network of the top 20 diseases related to Kernicterus:



Diseases related to kernicterus

Clinical Features for Kernicterus

Drugs & Therapeutics for Kernicterus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Kernicterus

Drug clinical trials:

Search ClinicalTrials for Kernicterus

Search NIH Clinical Center for Kernicterus

Search CenterWatch for Kernicterus

Genetic Tests for Kernicterus

Anatomical Context for Kernicterus

Sources:
33MalaCards
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MalaCards organs/tissues related to Kernicterus:

33
Liver, Brain, Breast, B cells, Endothelial, Globus pallidus

Animal Models for Kernicterus or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Kernicterus

Sources:
51PubMed
See all sources

Articles related to Kernicterus:

(show top 50)    (show all 333)
idTitleAuthorsYear
1
Medical education content required for kernicterus risk recognition. (23056881)
2012
2
Evidence suggests there was not a "resurgence" of kernicterus in the 1990s. (21444599)
2011
3
Fatal kernicterus in a girl deficient in glucose-6-phosphate dehydrogenase: a paradigm of synergistic heterozygosity. (19324225)
2009
4
Israel guidelines for the management of neonatal hyperbilirubinemia and prevention of kernicterus. (18322551)
2008
5
Kernicterus by glucose-6-phosphate dehydrogenase deficiency: a case report and review of the literature. (18460213)
2008
6
Magnetic resonance imaging of the brain in children with chronic kernicterus. (22266622)
2006
7
American Academy of Pediatrics guidelines for detecting neonatal hyperbilirubinaemia and preventing kernicterus. (16244203)
2005
8
Parents of Infants and Children with Kernicterus. (15729380)
2005
9
Urgent clinical need for accurate and precise bilirubin measurements in the United States to prevent kernicterus. (14726464)
2004
10
Newborn jaundice and kernicterus. Greater awareness and action needed. (15615221)
2004
11
Unbound bilirubin in a term newborn with kernicterus. (12728100)
2003
12
Pioneers in the scientific study of neonatal jaundice and kernicterus. (10920171)
2000
13
MR findings in a patient with Kernicterus. (10602975)
1999
14
New approach to prevention of kernicterus. (10359401)
1999
15
Newborn infants with yellow brains: the discovery of kernicterus in Germany, 1875-1908. (11619868)
1997
16
Bilirubin metabolism and kernicterus. (9265971)
1997
17
Kernicterus in a full-term infant: the need for increased vigilance. (7794367)
1995
18
Relationship of benzyl alcohol to kernicterus, intraventricular hemorrhage, and mortality in preterm infants. (2783624)
1989
19
Kernicterus in the premature neonate. (3333255)
1987
20
Prevention of kernicterus. (6540010)
1984
21
Bilirubin transport in the newborn infant, reviewed with relation to kernicterus. (6987352)
1980
22
Hyperbilirubinemia and the pathogenesis of kernicterus in the newborn. (390455)
1979
23
Is kernicterus due to inhibition of brain hexose-monophosphate shunt activity by bilirubin? (459982)
1979
24
Breakdown of blood/brain barrier in kernicterus. (67529)
1977
25
The use of critical levels of birth weight and "free bilirubin" as an approach for prevention of kernicterus. (1169077)
1975
26
Microdetermination of unbound bilirubin. Application to the prevention of kernicterus by estimation of the serum bilirubin binding capacity in neonatal hyperbilirubinemia. (4440153)
1974
27
An Iraqi Jewish family with a new red cell glucose-6-phosphate dehydrogenase variant (GD-Bagdad) and kernicterus. (4753845)
1973
28
Familial disease characterized by neonatal jaundice, and probable hepatosteatosis and kernicterus: a new syndrome? (4695852)
1973
29
Kernicterus in small sick premature infants receiving phototherapy. (5035415)
1972
30
Decline in serum bilirubin concentration coincident with clinical onset of kernicterus. (5114751)
1971
31
Hyperbilirubinemia and kernicterus in small premature infants. (5422115)
1970
32
Effect of sodium phenobarbital on bilirubin metabolism in an infant with congenital, nonhemolytic, unconjugated hyperbilirubinemia, and kernicterus. (5765026)
1969
33
KERNICTERUS IN NEWBORN RABBITS. (14266216)
1965
34
RED CELL GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY--A NEWLY RECOGNIZED CAUSE OF NEONATAL JAUNDICE AND KERNICTERUS IN CANADA. (14226101)
1964
35
EXPERIMENTAL KERNICTERUS IN THE NEWBORN MONKEY. (14272207)
1963
36
Kernicterus in Japanese infants. II. Pathologic data in 25 cases of kernicterus and in 20 cases of systemic icterus without kernicterus. (14421037)
1960
37
PREVENTION of kernicterus as a complication of hemolytic disease and other forms of jaundice of the newborn. (13651333)
1959
38
Hyperbilirubinaemia and kernicterus in premature and full-term Bantu newborn infants. (13638612)
1959
39
Kernicterus. (13838552)
1959
40
Kernicterus in premature infants associated with low concentrations of bilirubin in the plasma. (13553575)
1958
41
Clinical kernicterus and congenital hypothyroidism. (13493800)
1958
42
The sequelae of kernicterus. (13460354)
1957
43
Kernicterus in Japanese infants. I. Clinical and serological data from 25 patients. (13297516)
1956
44
Cerebrospinal fluid bilirubin in the neonatal period with special reference to the development of kernicterus; preliminary report. (13217811)
1954
45
Kernicterus following exchange transfusion. (13164384)
1954
46
Erythroblastosis fetalis. IV. Further observations on kernicterus. (14797333)
1950
47
Kernicterus; a review of the literature, with report of two cases. (18862290)
1948
48
Kernicterus; a review with a report of the findings in a study of seven cases. (18915135)
1948
49
The encephalopathy (kernicterus) of erythroblastosis fetalis, its serologic diagnosis and pathogenesis. (20276946)
1946
50
The encephalopathy (kernicterus) of erythroblastosis fetalis, its serologic diagnosis and pathogenesis. (21001969)
1946

Genetic Variations for Kernicterus

Expression for genes affiliated with Kernicterus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Kernicterus

Search GEO for disease gene expression data for Kernicterus.

Pathways for genes affiliated with Kernicterus

Sources:
50PharmGKB, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 30KEGG
See all sources

Pathways related to Kernicterus according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0UGT1A1, UGT1A9
210.0UGT1A4, UGT1A9
3
Hide members
10.0UGT1A4, UGT1A9
4
Hide members
9.9UGT1A4, UGT1A10
5
Hide members
9.9UGT1A1, UGT1A8
6
Hide members
9.6UGT1A10, UGT1A6, UGT1A9
79.5UGT1A8, UGT1A10, UGT1A3
8
Hide members
9.5UGT1A9, UGT1A1, UGT1A10, UGT1A3
9
Hide members
9.4UGT1A1, UGT1A6, UGT1A4, UGT1A9
10
Hide members
8.8UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A3
118.7UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A10, UGT1A3
12
Hide members
8.6UGT1A9, UGT1A4, UGT1A8, UGT1A1, UGT1A10, UGT2B28
13
Acetaminophen metabolism
Hide members
8.5UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
14
Hide members
8.2UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
15
Hide members
7.3UGT1A1, UGT1A5, UGT1A10, UGT2B28, UGT2A3, UGT1A7
16
Hide members
7.3UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
17
Hide members
7.3UGT1A6, UGT1A1, UGT1A5, UGT1A10, UGT2B28, UGT2A3
18
Hide members
7.1G6PD, UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1

Compounds for genes affiliated with Kernicterus

Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 50PharmGKB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Kernicterus according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1n-acetylbenzidine4510.1UGT1A1, UGT1A4, UGT1A9
2sn38 glucuronide4510.0UGT1A9, UGT1A1, UGT1A7
3acetaminophen glucuronide45 2411.0UGT1A1, UGT1A6, UGT1A9
4Ezogabine 119.9UGT1A3, UGT1A1, UGT1A4, UGT1A9
54-methylumbelliferone459.9UGT1A9, UGT1A6, UGT1A1
6flurbiprofen45 29 50 1112.9ALB, UGT1A3, UGT1A1, UGT1A9
71-naphthol459.8UGT1A9, UGT1A6, UGT1A1
8benzidine459.8UGT1A1, UGT1A6, UGT1A4, UGT1A9
9etodolac45 1110.8UGT1A9, UGT1A10, UGT1A3, ALB
10lamotrigine45 1110.7UGT1A4, UGT1A6, UGT1A1, UGT1A3
11phenol45 2410.7G6PD, UGT1A9, UGT1A6, UGT1A1
12trifluoperazine45 29 1111.7UGT1A1, UGT1A6, UGT1A4, UGT1A9
13udp glucuronic acid459.6UGT1A8, UGT1A6, UGT1A1, UGT1A10
14ibuprofen45 29 50 11 2413.6ALB, UGT1A3, UGT1A1, UGT1A9
15sulfamethoxazole45 50 1111.6ALB, UGT1A9, G6PD
16p-nitrophenol45 1110.5UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A3
17mycophenolate mofetil45 50 1111.5ALB, UGT1A10, UGT1A1, UGT1A8, UGT1A9
18irinotecan45 50 1111.5UGT1A9, UGT1A6, UGT1A1, UGT1A7, ALB
19benzo(a)pyrene459.4UGT1A9, UGT1A6, UGT1A1, UGT1A7
20amine459.4UGT1A3, UGT1A7, UGT1A1, UGT1A4
21uridine45 11 2411.4UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A7
22losartan45 50 29 1112.4UGT1A1, UGT1A10, UGT1A3, ALB
23diclofenac45 29 50 1112.3UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A3, ALB
24mycophenolic acid45 50 1111.2UGT1A9, UGT1A8, UGT1A1, UGT1A10, UGT1A7, ALB
25tamoxifen45 50 29 1112.2G6PD, UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A3
26morphine45 50 29 1112.1UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A3
27acetaminophen45 2 50 11 2413.0G6PD, UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A10
28glucuronide459.0UGT1A3, UGT1A7, UGT1A10, UGT1A9, UGT1A4, UGT1A6
29uridine diphosphate458.9UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A10, UGT1A7
30n-hydroxy phip458.9UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
31troglitazone45 29 60 1111.9UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
32propofol45 50 1110.7UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
33ethyl glucuronide45 249.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
34cotinine45 249.6UGT1A3, UGT1A7, UGT1A10, UGT1A9, UGT1A4, UGT1A8
35imipramine45 50 29 11 2412.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
36nicotine45 50 29 1111.5UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
37valproic acid45 50 11 2411.4UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
38(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)247.7UGT1A8, UGT1A6, UGT1A1, UGT1A5, UGT1A10, UGT2B28
39bilirubin diglucuronide45 248.7UGT1A6, UGT1A1, UGT1A5, UGT1A10, UGT2B28, UGT2A3
40aldosterone 18-glucuronide45 248.7UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
41codeine45 50 29 11 2411.7UGT1A6, UGT1A1, UGT1A5, UGT1A10, UGT2B28, UGT2A3
42etiocholanolone45 248.7UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
432-methoxyestradiol45 60 249.7UGT1A1, UGT1A5, UGT1A10, UGT2B28, UGT2A3, UGT1A7
44androsterone glucuronide45 248.7UGT1A1, UGT1A5, UGT1A10, UGT2B28, UGT2A3, UGT1A7
453-alpha-androstanediol glucuronide45 248.7UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
46estriol29 11 249.7UGT1A5, UGT1A10, UGT2B28, UGT2A3, UGT1A7, UGT1A3
47retinoic acid45 248.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
48estrone45 29 11 2410.5UGT1A5, UGT1A10, UGT2B28, UGT2A3, UGT1A7, UGT1A3
49estradiol45 11 249.5UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
50testosterone45 60 11 2410.3UGT1A8, UGT1A6, UGT1A1, UGT1A5, UGT1A10, UGT2B28

GO Terms for genes affiliated with Kernicterus

Sources:
16Gene Ontology
See all sources

Cellular components related to Kernicterus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular membrane-bounded organelleGO:0432319.1UGT1A5, UGT1A6, UGT1A8, UGT1A9, G6PD
2endoplasmic reticulum membraneGO:0057897.6UGT1A3, UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1
3integral to membraneGO:0160215.5UGT1A5, UGT1A6, UGT1A8, UGT3A1, UGT1A4, UGT1A9

Biological processes related to Kernicterus according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1coumarin metabolic processGO:0098049.8UGT1A7, UGT1A8
2negative regulation of steroid metabolic processGO:0459399.6UGT1A1, UGT1A8
3negative regulation of fatty acid metabolic processGO:0459229.5UGT1A9, UGT1A8, UGT1A7
4negative regulation of catalytic activityGO:0430869.4UGT1A7, UGT1A1, UGT1A8, UGT1A9
5flavonoid glucuronidationGO:0526969.3UGT1A9, UGT1A8, UGT1A1, UGT1A7, UGT1A3
6xenobiotic glucuronidationGO:0526979.3UGT1A3, UGT1A7, UGT1A1, UGT1A8, UGT1A9
7drug metabolic processGO:0171449.3UGT1A7, UGT1A1, UGT1A8, UGT1A9
8flavone metabolic processGO:0515529.2UGT1A9, UGT1A8, UGT1A1, UGT1A10, UGT1A7
9retinoic acid metabolic processGO:0425739.2UGT1A9, UGT1A8, UGT1A1, UGT1A7, UGT1A3
10cellular glucuronidationGO:0526959.2UGT1A4, UGT1A6, UGT1A1, UGT1A10, UGT2A3, UGT2A1
11xenobiotic metabolic processGO:0068059.1UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A5, UGT2B28
12metabolic processGO:0081528.9UGT2A1, UGT1A9, UGT1A6, UGT1A5, UGT1A10, UGT2B28

Molecular functions related to Kernicterus according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1fatty acid bindingGO:0055049.9ALB, UGT1A8
2ammonium transmembrane transporter activityGO:0085199.4RHD, RHCE
3enzyme inhibitor activityGO:0048579.4UGT1A7, UGT1A1, UGT1A8, UGT1A9
4drug bindingGO:0081449.3ALB, UGT1A7, UGT1A8
5UDP-glycosyltransferase activityGO:0081948.8UGT3A1, UGT3A2, UGT1A3
6retinoic acid bindingGO:0019728.4UGT1A3, UGT1A7, UGT1A10, UGT1A1, UGT1A6, UGT1A8
7protein heterodimerization activityGO:0469828.3UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
8enzyme bindingGO:0198998.2UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
9protein homodimerization activityGO:0428038.1G6PD, UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1
10glucuronosyltransferase activityGO:0150206.0UGT2A1, UGT1A9, UGT1A4, UGT3A1, UGT1A8, UGT1A3

Products for genes affiliated with Kernicterus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Kernicterus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet