MCID: KRN004
MIFTS: 46

Kernicterus malady

Categories: Rare diseases, Fetal diseases, Neuronal diseases, Metabolic diseases, Cancer diseases, Blood diseases, Skin diseases

Aliases & Classifications for Kernicterus

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Sources:
11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 52Orphanet, 48Novoseek, 2CDC, 37MeSH, 66UMLS, 28ICD10, 43NCIt, 29ICD10 via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Kernicterus:

Name: Kernicterus 11 46 13 52 48 2 37 66
Bilirubin Encephalopathy 11 46 52
 
Hyperbilirubinemic Encephalopathy 46

Characteristics:

Orphanet epidemiological data:

52
kernicterus:
Inheritance: Not applicable; Age of onset: Neonatal

Classifications:



External Ids:

Disease Ontology11 DOID:2382
ICD1028 P57, P57.9, P57.8
MeSH37 D007647
NCIt43 C84799
Orphanet52 ORPHA415286
ICD10 via Orphanet29 P57.9

Summaries for Kernicterus

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NIH Rare Diseases:46 Kernicterus is a rare condition that affects the brain. it refers to a form of brain damage that occurs when neonatal jaundice goes untreated for too long. the severity of the condition and the associated signs and symptoms vary significantly from person to person. people living with kernicterus may experience athetoid cerebral palsy, hearing loss, intellectual disability, vision abnormalities, and behavioral difficulties. approximately 60% of all newborn babies will have jaundice, a condition that is characterized by high level of bilirubin in the blood. risk factors for severe jaundice and higher bilirubin levels include premature birth (before 37 weeks); darker skin color; east asian or mediterranean descent; feeding difficulties; jaundice in a sibling; bruising at birth; and a mother with an o blood type or rh negative blood factor. early detection and management of jaundice can prevent kernicterus. last updated: 3/16/2016

MalaCards based summary: Kernicterus, also known as bilirubin encephalopathy, is related to crigler-najjar syndrome, type ii and crigler-najjar syndrome, type i, and has symptoms including bulging fontanelle, neonatal dyskinesia and tremor, neonatal. An important gene associated with Kernicterus is UGT1A1 (UDP Glucuronosyltransferase Family 1 Member A1), and among its related pathways are Nicotine Pathway, Pharmacokinetics and AhR pathway (WikiPathways). Affiliated tissues include brain, skin and globus pallidus.

Disease Ontology:11 A brain disease that is characterized by hyperbilirubinemia-induced brain dysfunction.

Wikipedia:69 Kernicterus is a bilirubin-induced brain dysfunction. Bilirubin is a highly neurotoxic substance that... more...

Related Diseases for Kernicterus

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Diseases in the Kernicterus family:

Kernicterus Due to Isoimmunization

Diseases related to Kernicterus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1crigler-najjar syndrome, type ii30.0UGT1A1, UGT1A4, UGT1A6, UGT1A9
2crigler-najjar syndrome, type i29.0UGT1A1, UGT1A4, UGT1A6, UGT1A9
3kernicterus due to isoimmunization12.2
4larynx sarcoma10.5G6PD, UGT1A1
5renal artery disease10.4G6PD, UGT1A1
6neonatal jaundice10.4
7spastic paraplegia 3a10.3G6PD, UGT1A1
8serpiginous choroiditis10.3ALB, G6PD
9bronchial disease10.3ALB, UGT1A1
10hemoglobin h disease, nondeletional10.2G6PD, UGT1A1
11encephalopathy10.2
12articulation disorder10.2RHCE, SLC4A1
13superficial keratitis10.2UGT1A1, UGT1A6
14ulcerative stomatitis10.2ALB, G6PD
15dihydropyrimidine dehydrogenase deficiency10.1UGT1A1, UGT1A6
16conjunctival vascular disease10.1ALB, RHCE
17adenylosuccinase lyase deficiency10.0ALB, SLC4A1
18pseudohypoparathyroidism10.0ALB, RHCE
19brain injury10.0
20cerebritis10.0
21blood group incompatibility10.0
22lucey-driscoll syndrome9.9
23common wart9.9ALB, SLC4A1
24hepatitis9.9
25neuronitis9.9
26thalassemia-beta, dominant inclusion-body9.9UGT1A1, UGT1A6
27plasmodium vivax malaria9.8SLC4A1, UGT1A1
28posterior foramen magnum meningioma9.8UGT1A1, UGT1A6
29cerebral palsy9.8
30hemolytic anemia9.8
31congenital hypothyroidism9.8
32aphasia9.8
33hereditary spherocytosis9.8
34hypothyroidism9.8
35rheumatic fever9.8
36viral hepatitis9.8
37congenital hemolytic anemia9.8
38central pontine myelinolysis9.8
39athetosis9.8
40anoxia9.8
41endotheliitis9.8
42fulminant viral hepatitis9.8
43dermatomyositis9.7ALB, UGT1A1, UGT1A6
44pyruvate kinase deficiency9.6G6PD, PKM, SLC4A1
45acute hydrops keratoconus9.4PKM, UGT1A1, UGT1A6
46auditory system disease9.1G6PD, UGT1A1, UGT1A4, UGT1A6, UGT1A9
47pyeloureteritis cystica8.9ALB, PKM, UGT1A1, UGT1A6
48wernicke encephalopathy6.9ALB, G6PD, PKM, RHCE, SLC4A1, UGT1A1

Graphical network of the top 20 diseases related to Kernicterus:



Diseases related to kernicterus

Symptoms for Kernicterus

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UMLS symptoms related to Kernicterus:


bulging fontanelle, neonatal dyskinesia, tremor, neonatal, yellow complexion, hepatocellular jaundice

Drugs & Therapeutics for Kernicterus

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Drugs for Kernicterus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
bilirubinPhase 4107635-65-45280352
Synonyms:
(4Z,15Z)-Bilirubin IXa
(Z,Z)-Bilirubin IXa
1,10,19,22,23,24-Hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionate
1,10,19,22,23,24-Hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionic acid
2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8,12-dipropanoate
2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8,12-dipropanoic acid
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoate
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
 
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-[(Z)-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-1H-pyrrol-2-yl)methyl)-4-methyl-5-[(Z)-(4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene
3-[2-[[3-(2-Carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate
3-[2-[[3-(2-Carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
3-[2-[[3-(2-Carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate
3-[2-[[3-(2-Carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
Bilirubin
Bilirubin IX-alpha
Cholerythrin
Hematoidin
2
Menthol21842216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol
3
Carbon monoxide108630-08-0281
Synonyms:
CO
 
Carbon monoxide
Carboneum oxygenisatum
carbon(II) oxide

Interventional clinical trials:

(show all 12)
idNameStatusNCT IDPhase
1Efficacy of High-dose Intravenous Immunoglobulin Therapy for Hyperbilirubinemia Due Rh Hemolytic DiseaseCompletedNCT00288600Phase 4
2Use of a New Phototherapy Device (BBloo®) for the Treatment of Hyperbilirubinemia in the Newborn InfantRecruitingNCT02156050Phase 4
3Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase DeficiencyRecruitingNCT02594904Phase 4
4Efficacy and Safety of Stannsoporfin in NeonatesCompletedNCT02685137Phase 3
5Does Maternal Instruction Prevent Kernicterus in Nigeria?CompletedNCT02713464
6Determining Prevalence of Acute Bilirubin Encephalopathy in Developing CountriesCompletedNCT01754688
7Implementation of a Transcutaneous BilirubinometerCompletedNCT01622699
8Follow-up of Extreme Neonatal Hyperbilirubinemia in 5-10 Year Old Children: a Danish Population Based StudyCompletedNCT01599611
9Bilirubin Binding Capacity to Assess Bilirubin Load in Preterm InfantsRecruitingNCT02691156
10Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment.RecruitingNCT02224586
11New Phototherapy Device to Treat Patients With Crigler-Najjar DiseaseActive, not recruitingNCT02356978
12Clinical and Developmental Outcomes of Babies Who Became Yellow in the First Month of LifeNot yet recruitingNCT02927093

Search NIH Clinical Center for Kernicterus


Cochrane evidence based reviews: kernicterus

Genetic Tests for Kernicterus

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Anatomical Context for Kernicterus

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MalaCards organs/tissues related to Kernicterus:

34
Brain, Skin, Globus pallidus, Breast, Liver, Endothelial

Animal Models for Kernicterus or affiliated genes

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Publications for Kernicterus

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Articles related to Kernicterus:

(show top 50)    (show all 344)
idTitleAuthorsYear
1
Kernicterus in Neonatal Jaundice-Finding the Needle in the Haystack. (26945202)
2016
2
Why is kernicterus still a major cause of death and disability in low-income and middle-income countries? (25123403)
2014
3
Jaundice and kernicterus in the moderately preterm infant. (24182955)
2013
4
MRI findings in kernicterus. (22990632)
2013
5
The Italian Registry of kernicterus and hyperbilirubinaemia. (22958040)
2012
6
Birth-related syndromes of athetosis and kernicterus. (21496597)
2011
7
Prevention of acute bilirubin encephalopathy and kernicterus in newborns. Position Statement #3049. NANN Board of Directors, March 2010. (20505419)
2010
8
A proposal to prevent severe neonatal hyperbilirubinemia and kernicterus. (19177062)
2009
9
Unbound bilirubin: a better predictor of kernicterus? (18160727)
2008
10
A new animal model of hemolytic hyperbilirubinemia-induced bilirubin encephalopathy (kernicterus). (18458656)
2008
11
Kernicterus in an adult dog. (17491082)
2007
12
Kernicterus, the Daubert decision, and evidence-based medicine. (17473112)
2007
13
Magnetic resonance imaging of the brain in children with chronic kernicterus. (22266622)
2006
14
Understanding severe hyperbilirubinemia and preventing kernicterus: adjuncts in the interpretation of neonatal serum bilirubin. (15936300)
2005
15
Parents of Infants and Children with Kernicterus. (15729380)
2005
16
Research on prevention of bilirubin-induced brain injury and kernicterus: National Institute of Child Health and Human Development conference executive summary. 2003. (15231933)
2004
17
NICHD Conference on Kernicterus: Research on Prevention of Bilirubin-Induced Brain Injury and Kernicterus: Bench-to-Bedside--Diagnostic Methods and Prevention and Treatment Strategies. (15129227)
2004
18
Kernicterus and G6PD deficiency--a case series from Oman. (12729287)
2003
19
Breast-feeding, neonatal jaundice and kernicterus. (12208098)
2002
20
System-based approach to management of neonatal jaundice and prevention of kernicterus. (12006952)
2002
21
From the Centers for Disease Control and Prevention. Kernicterus in full-term infants--United States, 1994-1998. (11474907)
2001
22
Benzyl alcohol, kernicterus, and unbound bilirubin. (11487763)
2001
23
Glucose 6-phosphate dehydrogenase deficiency with kernicterus: progressive late recovery from profound deafness. (9578122)
1998
24
Kernicterus in preterm infants; lest we forget (to turn on the lights) (1408550)
1992
25
A physiologic approach to identifying neonates at risk for kernicterus. (2376785)
1990
26
Auditory brainstem response in patients with a history of kernicterus. (3272525)
1988
27
Value and limitations of bilirubin binding capacity in predicting the development of kernicterus. (6466218)
1984
28
Kernicterus 1980: problems and practices viewed from the perspective of the practicing clinician. (6994988)
1980
29
Singapore kernicterus. (262490)
1979
30
Absence of kernicterus in low-birth weight infants from 1971 through 1976: comparison with findings in 1966 and 1967. (714577)
1978
31
Breakdown of blood/brain barrier in kernicterus. (67529)
1977
32
Kernicterus in a newborn female with G-6-PD deficiency. (978340)
1976
33
Hyperbilirubinemia and kernicterus in small premature infants. (5422115)
1970
34
The binding capacity of human albumin for bilirubin and its significance in the significance in the pathogenesis of kernicterus. (5450680)
1970
35
Hyperbilirubinemia and kernicterus in glucose-6-phosphate dehydrogenase-deficient infants in Singapore. (5652917)
1968
36
Risk of kernicterus in newborn infants with a high level of conjugated bilirubin. (6007580)
1966
37
KERNICTERUS IN NEWBORN RABBITS. (14266216)
1965
38
PREVENTION OF CEREBRAL DAMAGE (KERNICTERUS) FROM FOETO-MATERNAL INCOMPATIBILITY; ANTENATAL ASPECTS. (14062989)
1963
39
EXPERIMENTAL KERNICTERUS IN THE NEWBORN MONKEY. (14272207)
1963
40
Kernicterus. (13641893)
1959
41
Studies on kernicterus; relationship with sulfonamide intoxication, report on kernicterus in rats with glucuronyl transferase deficiency and review of pathogenesis. (13621251)
1959
42
Kernicterus in premature infants associated with low concentrations of bilirubin in the plasma. (13553575)
1958
43
Clinical kernicterus and congenital hypothyroidism. (13493800)
1958
44
Congenital cirrhosis of the liver with kernicterus; report of two cases in siblings with a discussion of the relationship to so-called neonatal hepatitis and to iso-immunization disease. (13268609)
1955
45
Prevention of death and crippling from kernicterus in hemolytic disease of the newborn. (13221977)
1954
46
Cerebrospinal fluid bilirubin in the neonatal period with special reference to the development of kernicterus; preliminary report. (13217811)
1954
47
Studies on the pathogenesis of kernicterus, with special reference to the nature of kernicteric pigment and its deposition under natural and experimental conditions. (13109106)
1953
48
Kernicterus and prematurity. (15422847)
1950
49
Central nervous system complications associated with kernicterus. (21011225)
1946
50
Case of Kernicterus. (19992043)
1939

Variations for Kernicterus

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Expression for genes affiliated with Kernicterus

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Search GEO for disease gene expression data for Kernicterus.

Pathways for genes affiliated with Kernicterus

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Pathways related to Kernicterus according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.5UGT1A4, UGT1A9
2
Show member pathways
9.5UGT1A1, UGT1A6
39.3G6PD, PKM
48.9UGT1A4, UGT1A6, UGT1A9
5
Show member pathways
8.6UGT1A1, UGT1A4, UGT1A6, UGT1A9
6
Show member pathways
8.6UGT1A1, UGT1A4, UGT1A6, UGT1A9
7
Show member pathways
8.6UGT1A1, UGT1A4, UGT1A6, UGT1A9
8
Show member pathways
8.6UGT1A1, UGT1A4, UGT1A6, UGT1A9
9
Show member pathways
8.6UGT1A1, UGT1A4, UGT1A6, UGT1A9
10
Show member pathways
8.6UGT1A1, UGT1A4, UGT1A6, UGT1A9
11
Show member pathways
8.6UGT1A1, UGT1A4, UGT1A6, UGT1A9
12
Show member pathways
8.6UGT1A1, UGT1A4, UGT1A6, UGT1A9
137.4G6PD, PKM, UGT1A1, UGT1A4, UGT1A6, UGT1A9
14
Show member pathways
6.6ALB, G6PD, PKM, SLC4A1, UGT1A1, UGT1A4

GO Terms for genes affiliated with Kernicterus

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Cellular components related to Kernicterus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:00057898.3UGT1A1, UGT1A4, UGT1A6, UGT1A9
2endoplasmic reticulumGO:00057838.0ALB, UGT1A1, UGT1A4, UGT1A6, UGT1A9
3extracellular exosomeGO:00700627.3ALB, G6PD, PKM, SLC4A1, UGT1A6, UGT1A9

Biological processes related to Kernicterus according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1bilirubin conjugationGO:000678910.3UGT1A1, UGT1A4
2heme catabolic processGO:004216710.2UGT1A1, UGT1A4
3flavone metabolic processGO:005155210.1UGT1A1, UGT1A9
4flavonoid biosynthetic processGO:00098139.6UGT1A1, UGT1A4, UGT1A6
5animal organ regenerationGO:00311009.4PKM, UGT1A1
6retinoic acid metabolic processGO:00425739.3UGT1A1, UGT1A9
7xenobiotic metabolic processGO:00068059.3UGT1A6, UGT1A9
8xenobiotic glucuronidationGO:00526979.1UGT1A1, UGT1A4, UGT1A6, UGT1A9
9flavonoid glucuronidationGO:00526969.1UGT1A1, UGT1A4, UGT1A6, UGT1A9
10cellular glucuronidationGO:00526959.1UGT1A1, UGT1A4, UGT1A6, UGT1A9
11response to nutrientGO:00075849.1ALB, PKM, UGT1A1

Molecular functions related to Kernicterus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:00198999.5ALB, SLC4A1, UGT1A1
2glucuronosyltransferase activityGO:00150209.1UGT1A1, UGT1A4, UGT1A6, UGT1A9
3retinoic acid bindingGO:00019729.0UGT1A1, UGT1A4, UGT1A6, UGT1A9
4protein heterodimerization activityGO:00469828.6UGT1A1, UGT1A4, UGT1A6, UGT1A9
5protein homodimerization activityGO:00428037.6G6PD, SLC4A1, UGT1A1, UGT1A4, UGT1A6, UGT1A9

Sources for Kernicterus

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
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30ICD9CM
31IUPHAR
32KEGG
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38MESH via Orphanet
39MGI
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44NDF-RT
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65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet