MCID: KRN004
MIFTS: 52

Kernicterus malady

Rare diseases, Neuronal diseases, Fetal diseases, Skin diseases, Blood diseases categories
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Summaries for Kernicterus

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Wikipedia:65 Kernicterus is a bilirubin-induced brain dysfunction. Bilirubin is a highly neurotoxic substance that... more...

MalaCards based summary: Kernicterus, also known as bilirubin encephalopathy, is related to blood group incompatibility and crigler-najjar syndrome. An important gene associated with Kernicterus is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Nicotine Pathway, Pharmacokinetics and Transport of vitamins, nucleosides, and related molecules. The compounds propofol and cotinine have been mentioned in the context of this disorder. Affiliated tissues include brain, globus pallidus and liver.

Aliases & Classifications for Kernicterus

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Kernicterus, Aliases & Descriptions:

Name: Kernicterus 8 42 10 44 62
Bilirubin Encephalopathy 8 42 62
Hyperbilirubinemic Encephalopathy 42 62
 
Kernicterus of Newborn 8 62
Kernicterus of Newborn Nos 8


Classifications:



External Ids:

Disease Ontology8 DOID:2382
MeSH34 D007647
NCIt39 C84799

Related Diseases for Kernicterus

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Diseases in the Kernicterus Due to Isoimmunization family:

kernicterus

Diseases related to Kernicterus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1blood group incompatibility31.1G6PD
2crigler-najjar syndrome30.9UGT1A1, UGT1A4
3neonatal jaundice30.9UGT1A1, G6PD, RHD
4crigler najjar syndrome, type 230.5UGT1A1, UGT1A4
5hereditary spherocytosis29.7UGT1A1, G6PD, RHD, SLC4A1
6hemolytic anemia29.7SLC4A1, RHD, G6PD, UGT1A1
7kernicterus due to isoimmunization10.5
8gilbert syndrome10.5UGT1A1
9hereditary elliptocytosis10.4SLC4A1
10glucosephosphate dehydrogenase deficiency10.4G6PD, UGT1A1
11alpha thalassemia10.4G6PD, UGT1A1
12acute kidney failure10.3G6PD, ALB
13cholelithiasis10.3UGT1A1, UGT1A6
14autoimmune hepatitis10.3UGT1A9, UGT1A1
15leukopenia10.2ALB, UGT1A1
16brain injury10.2
17cerebritis10.2
18autoimmune hemolytic anemia10.2G6PD, RHCE
19galactosemia10.2UGT1A1, ALB
20diarrhea10.2UGT1A6, UGT1A1, ALB
21hepatitis c10.2UGT1A7, UGT1A9, ALB
22bilirubin metabolic disorder10.2UGT1A7, UGT1A1, G6PD, ALB
23hepatitis10.1
24neuronitis10.1
25sepsis10.1
26cerebral palsy athetoid10.1
27beta thalassemia10.1RHD, G6PD, UGT1A1
28liver cancer10.0ALB, UGT1A1, UGT1A9, UGT1A7
29sickle cell disease10.0RHD, G6PD, UGT1A1
30congenital dyserythropoietic anemia10.0SLC4A1, RHD
31hyperhomocysteinemia10.0RHD, ALB
32metabolic acidosis10.0SLC4A1, ALB
33rh isoimmunization10.0RHD, RHCE
34cerebral palsy10.0
35rheumatic fever10.0
36central pontine myelinolysis10.0
37congenital hypothyroidism10.0
38aphasia10.0
39congenital hemolytic anemia10.0
40hypothyroidism10.0
41viral hepatitis10.0
42athetosis10.0
43lucey-driscoll syndrome10.0
44anoxia10.0
45endotheliitis10.0
46fulminant viral hepatitis10.0
47colorectal cancer10.0UGT1A7, UGT1A9, UGT1A6, UGT1A1
48liver cirrhosis10.0UGT1A7, ALB, RHD
49hepatitis b9.9RHD, ALB, UGT1A7
50malaria9.8SLC4A1, RHD, ALB, G6PD

Graphical network of the top 20 diseases related to Kernicterus:



Diseases related to kernicterus

Symptoms for Kernicterus

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Drugs & Therapeutics for Kernicterus

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Drug clinical trials:

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Search NIH Clinical Center for Kernicterus

Genetic Tests for Kernicterus

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Anatomical Context for Kernicterus

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MalaCards organs/tissues related to Kernicterus:

32
Brain, Globus pallidus, Liver, Breast, Endothelial

Animal Models for Kernicterus or affiliated genes

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Publications for Kernicterus

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Articles related to Kernicterus:

(show top 50)    (show all 337)
idTitleAuthorsYear
1
Jaundice and kernicterus in the moderately preterm infant. (24182955)
2013
2
The Italian Registry of kernicterus and hyperbilirubinaemia. (22958040)
2012
3
Fatal kernicterus in a girl deficient in glucose-6-phosphate dehydrogenase: a paradigm of synergistic heterozygosity. (19324225)
2009
4
Unbound bilirubin: a better predictor of kernicterus? (18160727)
2008
5
Kernicterus in an adult dog. (17491082)
2007
6
Kernicterus associated with hereditary spherocytosis and UGT1A1 promoter polymorphism. (16735790)
2006
7
Magnetic resonance imaging of the brain in children with chronic kernicterus. (22266622)
2006
8
Hyperintense globus pallidus on T1-weighted MR imaging in acute kernicterus: is it common or rare? (15565320)
2005
9
Bronze baby syndrome and the risk of kernicterus. (16188824)
2005
10
Understanding severe hyperbilirubinemia and preventing kernicterus: adjuncts in the interpretation of neonatal serum bilirubin. (15936300)
2005
11
Urgent clinical need for accurate and precise bilirubin measurements in the United States to prevent kernicterus. (14726464)
2004
12
Research on prevention of bilirubin-induced brain injury and kernicterus: National Institute of Child Health and Human Development conference executive summary. 2003. (15231933)
2004
13
Cost-effectiveness of strategies that are intended to prevent kernicterus in newborn infants. (15466085)
2004
14
Kernicterus and G6PD deficiency--a case series from Oman. (12729287)
2003
15
Breast-feeding, neonatal jaundice and kernicterus. (12208098)
2002
16
System-based approach to management of neonatal jaundice and prevention of kernicterus. (12006952)
2002
17
Preterm infants with athetoid cerebral palsy: kernicterus? (11207234)
2001
18
From the Centers for Disease Control and Prevention. Kernicterus in full-term infants--United States, 1994-1998. (11474907)
2001
19
Risk factors for kernicterus in term babies with non-hemolytic jaundice. (11463962)
2001
20
Kernicterus threatens healthy newborns. (11424865)
2001
21
Kernicterus in a full-term infant: the need for increased vigilance. (7724333)
1995
22
Kernicterus in preterm infants; lest we forget (to turn on the lights) (1408550)
1992
23
Assessing the risk of kernicterus using nuclear magnetic resonance. (2369802)
1990
24
Auditory brainstem response in patients with a history of kernicterus. (3272525)
1988
25
Kernicterus in the premature neonate. (3333255)
1987
26
Neonatal bilirubin toxicity. A review of kernicterus and the implications of drug-induced bilirubin displacement. (3304769)
1987
27
Value and limitations of bilirubin binding capacity in predicting the development of kernicterus. (6466218)
1984
28
Kernicterus at low levels of serum bilirubin: the impact of bilirubin albumin-binding capacity. A 10-year retrospective survey. (7199940)
1982
29
Kernicterus: effect on choline acetyltransferase, glutamic acid decarboxylase and tyrosine hydroxylase activities in the brain of the Gunn rat. (6105009)
1980
30
Singapore kernicterus. (262490)
1979
31
The pathochemistry of kernicterus. (43803)
1979
32
Absence of kernicterus in low-birth weight infants from 1971 through 1976: comparison with findings in 1966 and 1967. (714577)
1978
33
Breakdown of blood/brain barrier in kernicterus. (67529)
1977
34
An electron microscopic and radioautographic study on experimental kernicterus. I. Bilirubin transport via astroglia. (5815579)
1969
35
Serum albumin reserve PSP dye binding capacity in infants with kernicterus. (6067403)
1967
36
Risk of kernicterus in newborn infants with a high level of conjugated bilirubin. (6007580)
1966
37
KERNICTERUS IN NEWBORN RABBITS. (14266216)
1965
38
PREVENTION OF CEREBRAL DAMAGE (KERNICTERUS) FROM FOETO-MATERNAL INCOMPATIBILITY; ANTENATAL ASPECTS. (14062989)
1963
39
Kernicterus in premature infants associated with low concentrations of bilirubin in the plasma. (13553575)
1958
40
Clinical kernicterus and congenital hypothyroidism. (13493800)
1958
41
Congenital hemolytic anemia in the newborn; relationship to kernicterus. (13478296)
1957
42
Experimental studies on the pathogenesis of kernicterus. (13484304)
1957
43
Congenital cirrhosis of the liver with kernicterus; report of two cases in siblings with a discussion of the relationship to so-called neonatal hepatitis and to iso-immunization disease. (13268609)
1955
44
Prevention of death and crippling from kernicterus in hemolytic disease of the newborn. (13221977)
1954
45
Cerebrospinal fluid bilirubin in the neonatal period with special reference to the development of kernicterus; preliminary report. (13217811)
1954
46
The mechanism of production of kernicterus. (13000553)
1952
47
Kernicterus. (14819084)
1951
48
Central nervous system complications associated with kernicterus. (21011225)
1946
49
Pathogenesis of Kernicterus. (17800122)
1946
50
Case of Kernicterus. (19992043)
1939

Variations for Kernicterus

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Expression for genes affiliated with Kernicterus

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Expression patterns in normal tissues for genes affiliated with Kernicterus

Search GEO for disease gene expression data for Kernicterus.

Pathways for genes affiliated with Kernicterus

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Pathways related to Kernicterus according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Nicotine metabolism37
9.8UGT1A9, UGT1A4
2
Show member pathways
9.8SLC35A2, ALB
3
Show member pathways
bupropion degradation37
methylglyoxal degradation III37
nicotine degradation III37
nicotine degradation IV37
9.8UGT1A4, UGT1A10
4
Show member pathways
AhR pathway37
9.8UGT1A1, UGT1A6
5
Show member pathways
Codeine and morphine metabolism37
9.7UGT1A1, UGT1A8
69.6UGT1A10, UGT1A8
7
Show member pathways
9.6UGT1A10, UGT1A9, UGT1A1
89.5UGT1A9, UGT1A6, UGT1A1
9
Show member pathways
8.6UGT1A4, UGT1A9, UGT1A6, UGT1A8, UGT1A1
108.6UGT1A4, UGT1A9, UGT1A6, UGT1A8, UGT1A1
118.5UGT1A4, UGT1A10, UGT1A9, UGT1A6, UGT1A8
12
Show member pathways
7.9UGT1A7, UGT1A1, UGT1A8, UGT1A6, UGT1A9, UGT1A10
13
Show member pathways
7.6UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A5, UGT1A6
14
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism37
7.6UGT1A1, UGT1A8, UGT1A7, UGT1A4, UGT1A10, UGT1A9
15
Show member pathways
7.6UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A5, UGT1A6
16
Show member pathways
7.6UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A5, UGT1A6
17
Show member pathways
7.6UGT1A10, UGT1A4, UGT1A7, UGT1A9, UGT1A5, UGT1A6
18
Show member pathways
tetrapyrrole biosynthesis37
heme degradation37
Heme Biosynthesis37
heme biosynthesis37
heme biosynthesis from uroporphyrinogen-III I37
7.6UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
19
Show member pathways
6.6UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A5, UGT1A6

Compounds for genes affiliated with Kernicterus

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
See all sources

Compounds related to Kernicterus according to GeneCards/GeneDecks:

(show top 50)    (show all 167)
idCompoundScoreTop Affiliating Genes
1propofol44 50 1110.3UGT1A10, UGT1A4, UGT1A9, UGT1A6, UGT1A8, ALB
2cotinine44 249.2UGT1A1, UGT1A8, UGT1A6, UGT1A9, UGT1A10, UGT1A4
3Cortolone-3-glucuronide248.1UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A4, UGT1A7
4Estriol-16-Glucuronide248.1UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
5Estriol-17-glucuronide248.1UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
6Cotinineglucuronide248.1UGT1A7, UGT1A4, UGT1A10, UGT1A1, UGT1A8, UGT1A6
7Estrone glucuronide248.1UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A4
8Etiocholanolone glucuronide248.1UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
9Estriol-3-glucuronide248.1UGT1A7, UGT1A4, UGT1A1, UGT1A8, UGT1A6, UGT1A5
10Benzoyl glucuronide (Benzoic acid)248.1UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A4
11Bilirubin glucuronide248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
12Cholestane-3,7,12,25-tetrol-3-glucuronide248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
13Cholesterol glucuronide248.0UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A1, UGT1A8
14Cholic acid glucuronide248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
15Testosterone glucuronide248.0UGT1A4, UGT1A7, UGT1A1, UGT1A8, UGT1A6, UGT1A5
16Tetrahydroaldosterone-3-glucuronide248.0UGT1A9, UGT1A10, UGT1A4, UGT1A7, UGT1A5, UGT1A6
17Thyroxine glucuronide248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
18Testosterone sulfate248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
19Triiodothyronine glucuronide248.0UGT1A10, UGT1A4, UGT1A7, UGT1A9, UGT1A5, UGT1A6
20Tyramine glucuronide248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
21trans-3-Hydroxycotinine glucuronide248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
22Inodxyl glucuronide248.0UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A4, UGT1A7
23Isovalerylglucuronide248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
24Glycochenodeoxycholic acid 3-glucuronide248.0UGT1A7, UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9
25Retinyl beta-glucuronide248.0UGT1A5, UGT1A9, UGT1A10, UGT1A4, UGT1A7, UGT1A6
26Retinoyl b-glucuronide248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
27etiocholanolone44 249.0UGT1A5, UGT1A9, UGT1A10, UGT1A4, UGT1A7, UGT1A1
28bilirubin diglucuronide44 249.0UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A4
29(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
30aldosterone 18-glucuronide44 249.0UGT1A7, UGT1A4, UGT1A1, UGT1A8, UGT1A6, UGT1A5
311-Salicylate glucuronide248.0UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A4, UGT1A7
3211-beta-hydroxyandrosterone-3-glucuronide248.0UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
331-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid247.9UGT1A7, UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9
34codeine44 28 50 24 1111.9UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
35androsterone glucuronide44 248.9UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
363-alpha-androstanediol glucuronide44 248.9UGT1A7, UGT1A4, UGT1A10, UGT1A1, UGT1A8, UGT1A6
372-Phenylethanol glucuronide247.9UGT1A7, UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9
3825-Hydroxyvitamin D2-25-glucuronide247.9UGT1A10, UGT1A4, UGT1A7, UGT1A9, UGT1A5, UGT1A6
393,17-Androstanediol glucuronide247.8UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
4025-Hydroxyvitamin D2 25-(beta-glucuronide)247.8UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
413-alpha,20-alpha-dihydroxy-5-beta-pregnane 3-glucuronide247.8UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
42Bilirubin247.8UGT1A4, UGT1A7, UGT1A10, UGT1A9, UGT1A5, ALB
433-alpha-hydroxy-5-alpha-androstane-17-one 3-D-glucuronide247.8UGT1A4, UGT1A7, UGT1A10, UGT1A9, UGT1A5, UGT1A1
44Androsterone247.7UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
4517-hydroxyandrostane-3-glucuronide247.7UGT1A5, UGT1A9, UGT1A10, UGT1A4, UGT1A7, UGT1A6
46estrone44 28 24 1110.7ALB, UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9
472-Methoxy-estradiol-17b 3-glucuronide247.6UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
482-Methoxyestrone247.6UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
4911-Hydroxyprogesterone 11-glucuronide247.5UGT1A1, UGT1A8, UGT1A6, UGT1A5, UGT1A9, UGT1A10
502-Methoxyestrone 3-glucuronide247.3UGT1A9, UGT1A10, UGT1A4, UGT1A7, UGT1A5, UGT1A6

GO Terms for genes affiliated with Kernicterus

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Cellular components related to Kernicterus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:0057897.3UGT1A1, UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A5
2integral component of membraneGO:0160216.9UGT1A4, UGT1A10, UGT1A9, UGT1A5, UGT1A6, UGT1A8

Biological processes related to Kernicterus according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1coumarin metabolic processGO:0098049.6UGT1A8, UGT1A7
2negative regulation of fatty acid metabolic processGO:0459229.4UGT1A8, UGT1A9, UGT1A7
3negative regulation of steroid metabolic processGO:0459399.4UGT1A1, UGT1A8
4negative regulation of cellular glucuronidationGO:20010309.3UGT1A7, UGT1A9, UGT1A8, UGT1A1
5xenobiotic glucuronidationGO:0526979.3UGT1A7, UGT1A9, UGT1A8, UGT1A1
6flavonoid glucuronidationGO:0526969.3UGT1A7, UGT1A9, UGT1A8, UGT1A1
7cellular glucuronidationGO:0526959.3UGT1A4, UGT1A10, UGT1A6, UGT1A1
8retinoic acid metabolic processGO:0425739.2UGT1A1, UGT1A8, UGT1A9, UGT1A7
9drug metabolic processGO:0171449.2UGT1A7, UGT1A9, UGT1A8, UGT1A1
10negative regulation of catalytic activityGO:0430869.1UGT1A7, UGT1A9, UGT1A8, UGT1A1
11flavone metabolic processGO:0515529.0UGT1A1, UGT1A8, UGT1A9, UGT1A10, UGT1A7
12xenobiotic metabolic processGO:0068059.0UGT1A4, UGT1A9, UGT1A6, UGT1A1
13small molecule metabolic processGO:0442818.1UGT1A4, UGT1A9, UGT1A6, UGT1A1, G6PD, ALB

Molecular functions related to Kernicterus according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1protein kinase C bindingGO:0050809.8UGT1A10, UGT1A7
2fatty acid bindingGO:0055049.6ALB, UGT1A8
3drug bindingGO:0081449.4ALB, UGT1A8, UGT1A7
4steroid bindingGO:0054969.4UGT1A1, UGT1A8
5enzyme inhibitor activityGO:0048579.2UGT1A7, UGT1A9, UGT1A8, UGT1A1
6ammonium transmembrane transporter activityGO:0085199.0RHD, RHCE
7retinoic acid bindingGO:0019728.1UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A6, UGT1A8
8protein heterodimerization activityGO:0469828.1UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A6, UGT1A8
9glucuronosyltransferase activityGO:0150207.9UGT1A1, UGT1A7, UGT1A8, UGT1A6, UGT1A5, UGT1A9
10enzyme bindingGO:0198997.8UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A6, UGT1A8
11protein homodimerization activityGO:0428037.3UGT1A7, UGT1A4, UGT1A10, UGT1A9, UGT1A6, UGT1A8

Products for genes affiliated with Kernicterus

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  • Antibodies
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Sources for Kernicterus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet