MCID: KSH001
MIFTS: 31

Keshan Disease malady

Categories: Rare diseases, Metabolic diseases

Aliases & Classifications for Keshan Disease

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Aliases & Descriptions for Keshan Disease:

Name: Keshan Disease 11 48 13 68
Caused by Deficiency of Selenium in the Diet 48
 
Enlarged Heart and Poor Heart Function 48

Classifications:



External Ids:

Disease Ontology11 DOID:0050083

Summaries for Keshan Disease

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Wikipedia:71 Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium... more...

MalaCards based summary: Keshan Disease, also known as caused by deficiency of selenium in the diet, is related to cardiomyopathy and pancreatitis. An important gene associated with Keshan Disease is GPX1 (Glutathione Peroxidase 1), and among its related pathways are MHC class II antigen presentation and Rheumatoid arthritis. Affiliated tissues include heart, pancreatic islet and liver, and related mouse phenotype Increased shRNA abundance (Z-score > 2).

Related Diseases for Keshan Disease

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Diseases related to Keshan Disease via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1cardiomyopathy10.2
2pancreatitis10.0
3cystic fibrosis9.9
4dilated cardiomyopathy9.9
5mitochondrial cardiomyopathy9.9
6hepatitis9.7
7heart disease9.7
8myocarditis9.7
9ectothrix infectious disease7.5BMP5, BMP7, GPX1, HLA-DOA, HLA-DRA, SCN5A

Graphical network of diseases related to Keshan Disease:



Diseases related to keshan disease

Symptoms & Phenotypes for Keshan Disease

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GenomeRNAi Phenotypes related to Keshan Disease according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-358.8BMP7, GPX1, SCN5A

Drugs & Therapeutics for Keshan Disease

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Drugs for Keshan Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Sodium SelenitePhase 317
2Trace ElementsPhase 35802
3
SeleniumPhase 31757782-49-2
Synonyms:
Selanediide
Selenide
 
Selenide(2-)
Selenium
Selenium ion (Se2+)
4Protective AgentsPhase 37190
5MicronutrientsPhase 35802
6AntioxidantsPhase 32928

Interventional clinical trials:

idNameStatusNCT IDPhase
1Selenium Treatment and Chagasic Cardiopathy (STCC)RecruitingNCT00875173Phase 3

Search NIH Clinical Center for Keshan Disease

Genetic Tests for Keshan Disease

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Anatomical Context for Keshan Disease

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MalaCards organs/tissues related to Keshan Disease:

36
Heart, Pancreatic islet, Liver

Publications for Keshan Disease

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Articles related to Keshan Disease:

(show top 50)    (show all 56)
idTitleAuthorsYear
1
An approach to assessment of Keshan disease elimination at the township level. (27821502)
2016
2
Metabolism of arachidonic acid by the cytochrome P450 enzyme in patients with chronic Keshan disease and dilated cardiomyopathy. (26893848)
2016
3
Keshan disease, selenium deficiency, and the selenoproteome. (24785212)
2014
4
Serum biomarkers of Keshan disease assessed using a protein profiling approach based on ClinProt technique. (24841853)
2014
5
Long-term prognostic value of major and minor ECG abnormalities in latent Keshan disease with suspect chronic Keshan disease. (24975014)
2014
6
Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease. (24384427)
2014
7
H558R polymorphism in SCN5A is associated with Keshan disease and QRS prolongation in Keshan disease patients. (25177937)
2014
8
TLR2-ICAM1-Gadd45I+ axis mediates the epigenetic effect of selenium on DNA methylation and gene expression in Keshan disease. (24811888)
2014
9
The prevalence of Keshan disease in China. (23218571)
2013
10
Oxidative stress is involved in the pathogenesis of Keshan disease (an endemic dilated cardiomyopathy) in China. (24062877)
2013
11
An original discovery: selenium deficiency and Keshan disease (an endemic heart disease). (22705420)
2012
12
Analysis of glutathione peroxidase 1 gene polymorphism and Keshan disease in Heilongjiang Province, China. (22180033)
2011
13
The effect of DHEA treatment on the oxidative stress and myocardial fibrosis induced by Keshan disease pathogenic factors. (21602037)
2011
14
Suboptimal selenium supply--a continuing problem in Keshan disease areas in Heilongjiang province. (21253891)
2011
15
Is selenium deficiency really the cause of Keshan disease? (20574681)
2011
16
Selenium level surveillance for the year 2007 of Keshan disease in endemic areas and analysis on surveillance results between 2003 and 2007. (20180046)
2010
17
Chronic exposure to cereal mycotoxin likely citreoviridin may be a trigger for Keshan disease mainly through oxidative stress mechanism. (20034747)
2010
18
Polymorphisms in the glutathione peroxidase-1 gene associated with increased risk of Keshan disease]. (21055077)
2010
19
Circulating adhesion molecules in patients with Keshan disease and their relationship with Coxsackie B virus infection. (19399399)
2009
20
The study on relation of HLA-DRB1 gene polymorphism to Keshan disease and its association and linkage in the core families]. (17285554)
2007
21
Keshan disease and mitochondrial cardiomyopathy. (17312989)
2006
22
Coxsackievirus B3 infection and its mutation in Keshan disease. (15484304)
2004
23
Fulminant heart failure due to selenium deficiency cardiomyopathy (Keshan disease). (11848134)
2002
24
Selenite inhibition of Coxsackie virus B5 replication: implications on the etiology of Keshan disease. (11878751)
2002
25
Multifocal myocardial necrosis: a distinctive cardiac lesion in cystic fibrosis, lipomatous pancreatic atrophy, and Keshan disease. (12056507)
2002
26
HIV-associated cardiomyopathy is not Keshan disease. (12042392)
2002
27
High prevalence of enteroviral genomic sequences in myocardium from cases of endemic cardiomyopathy (Keshan disease) in China. (10814633)
2000
28
Alterations in rat pancreatic islet beta cells induced by Keshan disease pathogenic factors: protective action of selenium and vitamin E. (9550538)
1998
29
Morphological studies of myocardial fibrosis in different types of Keshan disease]. (11244934)
1998
30
Interacting nutritional and infectious etiologies of Keshan disease. Insights from coxsackie virus B-induced myocarditis in mice deficient in selenium or vitamin E. (9152508)
1997
31
Further investigation on the role of selenium deficiency in the aetiology and pathogenesis of Keshan disease. (9315325)
1997
32
A survey of moniliformin contamination in rice and corn from Keshan disease endemic and non-KSD areas in China. (8719174)
1995
33
Antioxidant status, erythrocyte fatty acids, and mortality from cardiovascular disease and Keshan disease in China. (7956986)
1994
34
Effects of selenium and alpha-tocopherol on liver damage induced by feeding grains from an endemic area of Keshan disease in rats. (7969093)
1994
35
Damage to hepatic thyroxine 5'-deiodination induced by pathogenic factors of Keshan disease and the preventive effects of selenium and vitamin E. (1781930)
1991
36
Common denominators in the etiology and pathology of visceral lesions of cystic fibrosis and Keshan disease. (1702672)
1990
37
The effect of selenium-fortified table salt in the prevention of Keshan disease on a population of 1.05 million. (2096847)
1990
38
Increased sarcolemmal membrane permeability of cardiac muscle cells in rats fed grains cultivated in a Keshan disease endemic area: a study with horseradish peroxidase as a tracer. (2721651)
1989
39
Keshan disease: an entity or not. (3402979)
1988
40
Keshan disease--an endemic mitochondrial cardiomyopathy in China. (2908794)
1988
41
Pancreatic lesions of Keshan disease and its significances. (3129250)
1987
42
Selenium and cardiomyopathy (Keshan disease). (3776583)
1986
43
Keshan disease: an endemic cardiomyopathy in China. (3997137)
1985
44
The role of selenium in Keshan disease. (6507187)
1984
45
M-mode echocardiographic features of children with Keshan disease. A preliminary observation of 106 cases. (6242288)
1984
46
Keshan disease-an endemic cardiomyopathy in China. (6412443)
1983
47
Pathology of Keshan disease. A comprehensive review. (6413138)
1983
48
Nutritional bio-geochemical etiology of Keshan disease. (6416757)
1983
49
A study of nutritional and bio-geochemical factors in the occurrence and development of Keshan disease. (7131711)
1982
50
Keshan disease and selenium in China. (7075240)
1982

Variations for Keshan Disease

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Expression for genes affiliated with Keshan Disease

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Search GEO for disease gene expression data for Keshan Disease.

Pathways for genes affiliated with Keshan Disease

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GO Terms for genes affiliated with Keshan Disease

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Cellular components related to Keshan Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.5HLA-DOA, HLA-DRA

Biological processes related to Keshan Disease according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.3BMP5, GPX1
2antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:001988610.2HLA-DOA, HLA-DRA
3BMP signaling pathwayGO:003050910.2BMP5, BMP7
4cartilage developmentGO:005121610.2BMP5, BMP7
5growthGO:004000710.2BMP5, BMP7
6ossificationGO:000150310.1BMP5, BMP7
7pattern specification processGO:000738910.1BMP5, BMP7
8positive regulation of dendrite developmentGO:190000610.1BMP5, BMP7
9positive regulation of pathway-restricted SMAD protein phosphorylationGO:001086210.0BMP5, BMP7
10odontogenesis of dentin-containing toothGO:00424759.8BMP7, SCN5A
11positive regulation of epithelial cell proliferationGO:00506799.7BMP5, SCN5A
12immune responseGO:00069559.6HLA-DOA, HLA-DRA, TNFSF15
13SMAD protein signal transductionGO:00603959.5BMP5, BMP7

Molecular functions related to Keshan Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1BMP receptor bindingGO:007070010.1BMP5, BMP7
2MHC class II protein complex bindingGO:002302610.0HLA-DOA, HLA-DRA
3MHC class II receptor activityGO:003239510.0HLA-DOA, HLA-DRA
4transforming growth factor beta receptor bindingGO:00051609.5BMP5, BMP7
5cytokine activityGO:00051259.4BMP5, BMP7, TNFSF15

Sources for Keshan Disease

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet