MCID: KSH001
MIFTS: 43

Keshan Disease malady

Rare diseases, Metabolic diseases categories
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Summaries for Keshan Disease

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Wikipedia:65 Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium... more...

MalaCards based summary: Keshan Disease, also known as caused by deficiency of selenium in the diet, is related to acute chest syndrome and pancreatitis. An important gene associated with Keshan Disease is DIO1 (deiodinase, iodothyronine, type I), and among its related pathways are African trypanosomiasis and Immune response MIF mediated glucocorticoid regulation. The compounds 12-hpete and 13-hydroperoxyoctadecadienoic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and pancreatic islet, and related mouse phenotypes are homeostasis/metabolism and growth/size/body.

Aliases & Classifications for Keshan Disease

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Keshan Disease, Aliases & Descriptions:

Name: Keshan Disease 8 42 10 62
Caused by Deficiency of Selenium in the Diet 42
 
Enlarged Heart and Poor Heart Function 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Metabolic diseases


External Ids:

Disease Ontology8 DOID:0050083

Related Diseases for Keshan Disease

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Diseases related to Keshan Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1acute chest syndrome10.4VCAM1
2pancreatitis10.3
3thyroiditis10.3HLA-DRB1
4cystic fibrosis10.2
5mitochondrial cardiomyopathy10.2
6rheumatoid vasculitis10.2ICAM1, VCAM1
7arteriosclerosis obliterans10.2VCAM1, ICAM1
8immunoglobulin a vasculitis10.2ICAM1, VCAM1
9vascular disease10.2GPX5, GPX1, GPX4
10inclusion body myositis10.2ICAM1, VCAM1
11cork-handlers' disease10.2GPX1, GPX4, GPX5
12leukostasis10.2VCAM1, ICAM1
13toxic encephalopathy10.2GPX4, GPX5, GPX1
14prion disease10.2GPX4, GPX5, GPX1
15oral lichen planus10.2VCAM1, ICAM1
16hyperhomocysteinemia10.2VCAM1, GPX1
17arteriosclerosis10.2ICAM1, VCAM1
18proliferative diabetic retinopathy10.1ICAM1, VCAM1
19rhinitis10.1VCAM1, ICAM1
20lupus nephritis10.1VCAM1, ICAM1
21dilated cardiomyopathy10.1
22hepatitis10.1
23myocarditis10.1
24dermatomyositis10.1VCAM1, ICAM1
25polymyositis10.1VCAM1, ICAM1
26myositis10.0VCAM1, ICAM1
27diabetic retinopathy10.0ICAM1, VCAM1
28coronary artery anomaly10.0ICAM1, VCAM1, GPX1
29arthritis10.0ICAM1, HLA-DRB1
30synovitis10.0VCAM1, ICAM1
31pre-eclampsia10.0GPX3, VCAM1, ICAM1
32galactosemia10.0GPX1, GPX5, GPX4, ICAM1
33hyperglycemia9.9GPX4, VCAM1, GPX1, GPX5
34vernal keratoconjunctivitis9.9ICAM1, VCAM1, CD36
35cerebral malaria9.9CD36, ICAM1, VCAM1
36myeloma9.9VCAM1, CD36, ICAM1
37primary hyperoxaluria9.8VCAM1, CD36, GPX3
38connective tissue disease9.8HLA-DRB1, VCAM1, ICAM1
39graves' disease9.8ICAM1, HLA-DRB1, VCAM1
40plasmodium falciparum malaria9.8HLA-DRB1, CD36, ICAM1
41systemic lupus erythematosus9.8VCAM1, ICAM1, HLA-DRB1
42psoriasis9.8VCAM1, HLA-DRB1, ICAM1
43multiple sclerosis9.8VCAM1, ICAM1, HLA-DRB1
44atherosclerosis9.7ICAM1, VCAM1, CD36, GPX1
45congenital heart disease9.7VCAM1, ICAM1, GPX5, GPX1, GPX4
46malaria9.6CD36, HLA-DRB1, GPX1, ICAM1
47systemic scleroderma9.6CD36, HLA-DRB1, VCAM1, ICAM1
48leukemia9.5ICAM1, GPX4, GPX1, HLA-DRB1
49hypersensitivity reaction type ii disease9.5HLA-DRB1, VCAM1, ICAM1
50melanoma9.5ICAM1, HLA-DRB1, CD36, VCAM1

Graphical network of the top 20 diseases related to Keshan Disease:



Diseases related to keshan disease

Symptoms for Keshan Disease

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Drugs & Therapeutics for Keshan Disease

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Drug clinical trials:

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Genetic Tests for Keshan Disease

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Anatomical Context for Keshan Disease

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MalaCards organs/tissues related to Keshan Disease:

32
Heart, Liver, Pancreatic islet

Animal Models for Keshan Disease or affiliated genes

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MGI Mouse Phenotypes related to Keshan Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.2CD36, ICAM1, DIO1, VCAM1, GPX1, GPX3
2MP:00053787.6CD36, GPX3, GPX1, GPX4, VCAM1, DIO1

Publications for Keshan Disease

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Articles related to Keshan Disease:

(show top 50)    (show all 52)
idTitleAuthorsYear
1
Keshan disease, selenium deficiency, and the selenoproteome. (24785212)
2014
2
H558R polymorphism in SCN5A is associated with Keshan disease and QRS prolongation in Keshan disease patients. (25177937)
2014
3
Serum biomarkers of Keshan disease assessed using a protein profiling approach based on ClinProt technique. (24841853)
2014
4
Long-term prognostic value of major and minor ECG abnormalities in latent Keshan disease with suspect chronic Keshan disease. (24975014)
2014
5
TLR2-ICAM1-Gadd45I+ axis mediates the epigenetic effect of selenium on DNA methylation and gene expression in Keshan disease. (24811888)
2014
6
Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease. (24384427)
2014
7
The prevalence of Keshan disease in China. (23218571)
2013
8
Oxidative stress is involved in the pathogenesis of Keshan disease (an endemic dilated cardiomyopathy) in China. (24062877)
2013
9
An original discovery: selenium deficiency and Keshan disease (an endemic heart disease). (22705420)
2012
10
Analysis of glutathione peroxidase 1 gene polymorphism and Keshan disease in Heilongjiang Province, China. (22180033)
2011
11
The effect of DHEA treatment on the oxidative stress and myocardial fibrosis induced by Keshan disease pathogenic factors. (21602037)
2011
12
Is selenium deficiency really the cause of Keshan disease? (20574681)
2011
13
Selenium level surveillance for the year 2007 of Keshan disease in endemic areas and analysis on surveillance results between 2003 and 2007. (20180046)
2010
14
Chronic exposure to cereal mycotoxin likely citreoviridin may be a trigger for Keshan disease mainly through oxidative stress mechanism. (20034747)
2010
15
Polymorphisms in the glutathione peroxidase-1 gene associated with increased risk of Keshan disease]. (21055077)
2010
16
Circulating adhesion molecules in patients with Keshan disease and their relationship with Coxsackie B virus infection. (19399399)
2009
17
The study on relation of HLA-DRB1 gene polymorphism to Keshan disease and its association and linkage in the core families]. (17285554)
2007
18
Keshan disease and mitochondrial cardiomyopathy. (17312989)
2006
19
Coxsackievirus B3 infection and its mutation in Keshan disease. (15484304)
2004
20
Multifocal myocardial necrosis: a distinctive cardiac lesion in cystic fibrosis, lipomatous pancreatic atrophy, and Keshan disease. (12056507)
2002
21
Selenite inhibition of Coxsackie virus B5 replication: implications on the etiology of Keshan disease. (11878751)
2002
22
HIV-associated cardiomyopathy is not Keshan disease. (12042392)
2002
23
High prevalence of enteroviral genomic sequences in myocardium from cases of endemic cardiomyopathy (Keshan disease) in China. (10814633)
2000
24
Morphological studies of myocardial fibrosis in different types of Keshan disease]. (11244934)
1998
25
Alterations in rat pancreatic islet beta cells induced by Keshan disease pathogenic factors: protective action of selenium and vitamin E. (9550538)
1998
26
Interacting nutritional and infectious etiologies of Keshan disease. Insights from coxsackie virus B-induced myocarditis in mice deficient in selenium or vitamin E. (9152508)
1997
27
Further investigation on the role of selenium deficiency in the aetiology and pathogenesis of Keshan disease. (9315325)
1997
28
A survey of moniliformin contamination in rice and corn from Keshan disease endemic and non-KSD areas in China. (8719174)
1995
29
Antioxidant status, erythrocyte fatty acids, and mortality from cardiovascular disease and Keshan disease in China. (7956986)
1994
30
Damage to hepatic thyroxine 5'-deiodination induced by pathogenic factors of Keshan disease and the preventive effects of selenium and vitamin E. (1781930)
1991
31
Common denominators in the etiology and pathology of visceral lesions of cystic fibrosis and Keshan disease. (1702672)
1990
32
The effect of selenium-fortified table salt in the prevention of Keshan disease on a population of 1.05 million. (2096847)
1990
33
Increased sarcolemmal membrane permeability of cardiac muscle cells in rats fed grains cultivated in a Keshan disease endemic area: a study with horseradish peroxidase as a tracer. (2721651)
1989
34
Keshan disease: an entity or not. (3402979)
1988
35
Keshan disease--an endemic mitochondrial cardiomyopathy in China. (2908794)
1988
36
Pancreatic lesions of Keshan disease and its significances. (3129250)
1987
37
Selenium and cardiomyopathy (Keshan disease). (3776583)
1986
38
Keshan disease: an endemic cardiomyopathy in China. (3997137)
1985
39
The role of selenium in Keshan disease. (6507187)
1984
40
Nutritional bio-geochemical etiology of Keshan disease. (6416757)
1983
41
Keshan disease-an endemic cardiomyopathy in China. (6412443)
1983
42
Pathology of Keshan disease. A comprehensive review. (6413138)
1983
43
Keshan disease and selenium in China. (7075240)
1982
44
A study of nutritional and bio-geochemical factors in the occurrence and development of Keshan disease. (7131711)
1982
45
Studies on the relations of selenium and Keshan disease. (24272892)
1980
46
On the etiology of Keshan disease: two hypotheses. (110554)
1979
47
Epidemiologic studies on the etiologic relationship of selenium and Keshan disease. (114372)
1979
48
Observations on effect of sodium selenite in prevention of Keshan disease. (114371)
1979
49
The vetosidum in the treatment of Keshan disease. (411634)
1977
50
PATHOLOGIC CHANGES OF THE CONDUCTION SYSTEM OF THE HEART IN 43 CASES OF KESHAN DISEASE. (14191216)
1964

Variations for Keshan Disease

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Expression for genes affiliated with Keshan Disease

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Expression patterns in normal tissues for genes affiliated with Keshan Disease

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Pathways for genes affiliated with Keshan Disease

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Pathways related to Keshan Disease according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ICAM1, VCAM1
29.7ICAM1, VCAM1
39.7ICAM1, VCAM1
49.7ICAM1, VCAM1
5
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.7ICAM1, VCAM1
69.7GPX3, GPX1
79.6ICAM1, HLA-DRB1
89.3CD36, ICAM1, VCAM1
99.3CD36, ICAM1, VCAM1
10
Show member pathways
9.3HLA-DRB1, VCAM1, ICAM1
119.3ICAM1, VCAM1, HLA-DRB1
129.3ICAM1, VCAM1, HLA-DRB1
13
Show member pathways
9.1GPX3, GPX1, GPX8
14
Show member pathways
9.1GPX8, GPX1, GPX3
15
Show member pathways
8.9HLA-DRB1, VCAM1, ICAM1, CD36
16
Show member pathways
Vitamin B12 Metabolism37
8.5GPX4, GPX6, GPX1, GPX3
178.2GPX3, GPX1, GPX6, GPX4, DIO1
18
Show member pathways
thioredoxin pathway37
7.8GPX3, GPX1, GPX6, GPX4, DIO1, ICAM1
19
Show member pathways
7.7GPX3, GPX5, GPX1, GPX6, GPX8
20
Show member pathways
7.4GPX3, GPX5, GPX1, GPX6, GPX4, GPX8
21
Show member pathways
glutathione-mediated detoxification I37
glutathione redox reactions I37
glutathione redox reactions II37
4-hydroxy-2-nonenal detoxification37
Glutathione metabolism60
Glutathione metabolism37
7.4GPX8, GPX4, GPX6, GPX1, GPX5, GPX3

Compounds for genes affiliated with Keshan Disease

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Compounds related to Keshan Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
112-hpete4410.2GPX4, GPX1
213-hydroperoxyoctadecadienoic acid4410.2GPX4, VCAM1
312-hydroxyeicosatetraenoic acid4410.1GPX4, GPX1
4linoleic acid hydroperoxide4410.0GPX3, GPX4
5sodium cromoglycate4410.0ICAM1, VCAM1
6selenite4410.0DIO1, GPX4, GPX1
711-deoxy-pge14410.0CD36, ICAM1
8loratadine44 24 1112.0ICAM1, VCAM1
98 methoxypsoralen4410.0ICAM1, VCAM1
10selenomethionine44 2411.0GPX3, GPX4
11sele449.9VCAM1, ICAM1
12helenalin449.8ICAM1, VCAM1
13hydroxide449.8GPX3, GPX4
14gliclazide44 50 1111.8ICAM1, VCAM1
15hcec449.7ICAM1, VCAM1
16malondialdehyde449.7GPX4, GPX1, GPX3
17budesonide44 50 1111.7VCAM1, ICAM1, CD36
18homocysteine44 2410.7VCAM1, GPX1, GPX3
19acetone449.6CD36, ICAM1
20troglitazone44 28 61 1112.6CD36, ICAM1, VCAM1
21cytochalasin d44 6110.6VCAM1, ICAM1, CD36
228-isoprostane449.6ICAM1, VCAM1, GPX3
23herbimycin a44 6110.6CD36, ICAM1, VCAM1
24hyaluronic acid44 2410.5VCAM1, ICAM1, CD36
25selenocysteine44 24 1111.5DIO1, GPX4, GPX1, GPX3
26n acetylcysteine449.5ICAM1, VCAM1, GPX4, GPX1
27manganese superoxide449.4GPX3, GPX1, GPX4, VCAM1
28vitamin-e449.4GPX3, GPX1, GPX4, VCAM1
29pge2449.3GPX4, VCAM1, ICAM1, CD36
30superoxide44 2410.3GPX3, GPX1, GPX4, VCAM1
31nadph44 2410.3VCAM1, GPX4, GPX1, GPX5
32cysteine449.2GPX1, GPX4, VCAM1, DIO1, CD36
33ascorbic acid44 2410.2GPX3, GPX4, ICAM1, CD36
34phosphatidylcholine449.2VCAM1, GPX4, GPX3
35alpha tocopherol449.0GPX3, GPX1, GPX4, VCAM1, CD36
36cholesterol44 28 24 1112.0GPX3, GPX1, GPX4, VCAM1
37h2o2448.9GPX3, GPX1, GPX4, ICAM1, CD36
38oxygen44 249.9GPX3, GPX1, GPX4, VCAM1, ICAM1
39lipid448.6VCAM1, GPX4, GPX1, GPX5, GPX3
40dexamethasone44 50 28 1111.5GPX3, VCAM1, ICAM1, CD36
4115(S)-HETE248.3GPX4, GPX3, GPX5, GPX1, GPX6
425-HETE248.3GPX3, GPX5, GPX1, GPX6, GPX4
435(S)-Hydroperoxyeicosatetraenoic acid248.3GPX3, GPX5, GPX1, GPX6, GPX4
445-hpete44 249.3GPX4, GPX6, GPX1, GPX5, GPX3
45Oxidized glutathione248.3GPX3, GPX5, GPX1, GPX6, GPX4
4615(S)-HPETE248.3GPX3, GPX5, GPX1, GPX6, GPX4
47Hydrogen peroxide248.3GPX3, GPX5, GPX1, GPX6, GPX4
48Water248.3GPX3, GPX5, GPX1, GPX6, GPX4
49selenium44 249.0GPX3, GPX5, GPX1, GPX6, GPX4, DIO1
50Glutathione24 118.8GPX3, GPX5, GPX1, GPX6, GPX4, GPX8

GO Terms for genes affiliated with Keshan Disease

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Cellular components related to Keshan Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle membraneGO:0306669.7CD36, HLA-DRB1
2external side of plasma membraneGO:0098978.6CD36, ICAM1, VCAM1, HLA-DRB1

Biological processes related to Keshan Disease according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1lipoxygenase pathwayGO:01937210.1GPX4, GPX1
2response to nicotineGO:03509410.0GPX1, VCAM1
3response to lipid hydroperoxideGO:0069829.9GPX1, GPX3
4membrane to membrane dockingGO:0226149.9VCAM1, ICAM1
5glutathione metabolic processGO:0067499.9GPX4, GPX1
6leukocyte cell-cell adhesionGO:0071599.9ICAM1, VCAM1
7heterophilic cell-cell adhesionGO:0071579.8ICAM1, VCAM1
8agingGO:0075689.7GPX1, GPX4, VCAM1
9cellular response to glucose stimulusGO:0713339.7VCAM1, ICAM1
10cellular response to tumor necrosis factorGO:0713569.7ICAM1, VCAM1
11hydrogen peroxide catabolic processGO:0427449.6GPX4, GPX1, GPX3
12response to ionizing radiationGO:0102129.6ICAM1, VCAM1
13arachidonic acid metabolic processGO:0193699.6GPX4, GPX1
14interferon-gamma-mediated signaling pathwayGO:0603339.5ICAM1, VCAM1, HLA-DRB1
15cytokine-mediated signaling pathwayGO:0192219.4ICAM1, VCAM1, HLA-DRB1
16response to oxidative stressGO:0069798.8GPX8, GPX6, GPX5

Molecular functions related to Keshan Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione bindingGO:0432959.9GPX4, GPX1
2phospholipid-hydroperoxide glutathione peroxidase activityGO:0470669.6GPX4, GPX1
3selenium bindingGO:0084308.9GPX3, GPX1, GPX4, DIO1
4glutathione peroxidase activityGO:0046027.4GPX8, GPX4, GPX6, GPX1, GPX5, GPX3

Products for genes affiliated with Keshan Disease

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Sources for Keshan Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet