MCID: KSH001
MIFTS: 42

Keshan Disease malady

Rare diseases category

Summaries for Keshan Disease

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66Wikipedia, 34MalaCards
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Wikipedia:66 Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium... more...

MalaCards: Keshan Disease, also known as caused by deficiency of selenium in the diet, is related to pancreatitis and cystic fibrosis. An important gene associated with Keshan Disease is DIO1 (deiodinase, iodothyronine, type I), and among its related pathways are African trypanosomiasis and Immune response MIF mediated glucocorticoid regulation. The compounds 12-hpete and 13-hydroperoxyoctadecadienoic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and pancreatic islet, and related mouse phenotypes are homeostasis/metabolism and growth/size/body.

Aliases & Classifications for Keshan Disease

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

keshan disease 9 44 11 63
caused by deficiency of selenium in the diet 44
enlarged heart and poor heart function 44


External Ids:

Disease Ontology9 DOID:0050083

Related Diseases for Keshan Disease

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18GeneCards, 19GeneDecks
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Diseases related to Keshan Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis10.3
2cystic fibrosis10.2
3mitochondrial cardiomyopathy10.2
4acute chest syndrome10.1VCAM1
5dilated cardiomyopathy10.1
6hepatitis10.1
7myocarditis10.1
8thyroiditis10.1HLA-DRB1
9rheumatoid vasculitis10.0ICAM1, VCAM1
10arteriosclerosis obliterans10.0ICAM1, VCAM1
11immunoglobulin a vasculitis10.0ICAM1, VCAM1
12vascular disease10.0GPX4, GPX1, GPX5
13inclusion body myositis10.0VCAM1, ICAM1
14cork-handlers' disease10.0GPX5, GPX1, GPX4
15leukostasis10.0VCAM1, ICAM1
16toxic encephalopathy10.0GPX4, GPX1, GPX5
17prion disease10.0GPX4, GPX1, GPX5
18oral lichen planus10.0ICAM1, VCAM1
19hyperhomocysteinemia10.0GPX1, VCAM1
20arteriosclerosis10.0ICAM1, VCAM1
21proliferative diabetic retinopathy10.0VCAM1, ICAM1
22rhinitis10.0VCAM1, ICAM1
23lupus nephritis10.0VCAM1, ICAM1
24dermatomyositis10.0VCAM1, ICAM1
25polymyositis10.0ICAM1, VCAM1
26myositis10.0VCAM1, ICAM1
27diabetic retinopathy10.0ICAM1, VCAM1
28coronary artery disease10.0ICAM1, VCAM1, GPX1
29arthritis10.0ICAM1, HLA-DRB1
30synovitis10.0VCAM1, ICAM1
31pre-eclampsia10.0GPX3, VCAM1, ICAM1
32galactosemia10.0GPX5, GPX1, GPX4, ICAM1
33hyperglycemia10.0GPX5, GPX1, GPX4, VCAM1
34vernal keratoconjunctivitis10.0VCAM1, ICAM1, CD36
35cerebral malaria10.0VCAM1, ICAM1, CD36
36myeloma10.0CD36, ICAM1, VCAM1
37primary hyperoxaluria10.0CD36, VCAM1, GPX3
38connective tissue disease10.0HLA-DRB1, VCAM1, ICAM1
39graves' disease10.0HLA-DRB1, VCAM1, ICAM1
40plasmodium falciparum malaria9.9CD36, ICAM1, HLA-DRB1
41systemic lupus erythematosus9.9HLA-DRB1, VCAM1, ICAM1
42psoriasis9.9ICAM1, VCAM1, HLA-DRB1
43multiple sclerosis9.9ICAM1, VCAM1, HLA-DRB1
44atherosclerosis9.9GPX1, VCAM1, ICAM1, CD36
45congenital heart disease9.9ICAM1, VCAM1, GPX4, GPX1, GPX5
46malaria9.9HLA-DRB1, GPX1, ICAM1, CD36
47systemic scleroderma9.9CD36, ICAM1, VCAM1, HLA-DRB1
48leukemia9.9ICAM1, GPX4, GPX1, HLA-DRB1
49hypersensitivity reaction type ii disease9.9ICAM1, VCAM1, HLA-DRB1
50melanoma9.9CD36, ICAM1, VCAM1, HLA-DRB1

Graphical network of the top 20 diseases related to Keshan Disease:



Diseases related to keshan disease

Symptoms for Keshan Disease

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Drugs & Therapeutics for Keshan Disease

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Keshan Disease

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Anatomical Context for Keshan Disease

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34MalaCards
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MalaCards organs/tissues related to Keshan Disease:

34
Heart, Liver, Pancreatic islet

Animal Models for Keshan Disease or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Keshan Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.2CD36, ICAM1, DIO1, VCAM1, GPX1, GPX3
2MP:00053787.6CD36, GPX3, GPX1, GPX4, VCAM1, DIO1

Publications for Keshan Disease

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53PubMed
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Articles related to Keshan Disease:

(show all 48)
idTitleAuthorsYear
1
Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease. (24384427)
2014
2
The prevalence of Keshan disease in China. (23218571)
2013
3
Oxidative stress is involved in the pathogenesis of Keshan disease (an endemic dilated cardiomyopathy) in China. (24062877)
2013
4
An original discovery: selenium deficiency and Keshan disease (an endemic heart disease). (22705420)
2012
5
Analysis of glutathione peroxidase 1 gene polymorphism and Keshan disease in Heilongjiang Province, China. (22180033)
2011
6
The effect of DHEA treatment on the oxidative stress and myocardial fibrosis induced by Keshan disease pathogenic factors. (21602037)
2011
7
Suboptimal selenium supply--a continuing problem in Keshan disease areas in Heilongjiang province. (21253891)
2011
8
Is selenium deficiency really the cause of Keshan disease? (20574681)
2011
9
Selenium level surveillance for the year 2007 of Keshan disease in endemic areas and analysis on surveillance results between 2003 and 2007. (20180046)
2010
10
Chronic exposure to cereal mycotoxin likely citreoviridin may be a trigger for Keshan disease mainly through oxidative stress mechanism. (20034747)
2010
11
Polymorphisms in the glutathione peroxidase-1 gene associated with increased risk of Keshan disease]. (21055077)
2010
12
Circulating adhesion molecules in patients with Keshan disease and their relationship with Coxsackie B virus infection. (19399399)
2009
13
The study on relation of HLA-DRB1 gene polymorphism to Keshan disease and its association and linkage in the core families]. (17285554)
2007
14
Keshan disease and mitochondrial cardiomyopathy. (17312989)
2006
15
Coxsackievirus B3 infection and its mutation in Keshan disease. (15484304)
2004
16
Multifocal myocardial necrosis: a distinctive cardiac lesion in cystic fibrosis, lipomatous pancreatic atrophy, and Keshan disease. (12056507)
2002
17
Fulminant heart failure due to selenium deficiency cardiomyopathy (Keshan disease). (11848134)
2002
18
Selenite inhibition of Coxsackie virus B5 replication: implications on the etiology of Keshan disease. (11878751)
2002
19
HIV-associated cardiomyopathy is not Keshan disease. (12042392)
2002
20
High prevalence of enteroviral genomic sequences in myocardium from cases of endemic cardiomyopathy (Keshan disease) in China. (10814633)
2000
21
Morphological studies of myocardial fibrosis in different types of Keshan disease]. (11244934)
1998
22
Alterations in rat pancreatic islet beta cells induced by Keshan disease pathogenic factors: protective action of selenium and vitamin E. (9550538)
1998
23
Interacting nutritional and infectious etiologies of Keshan disease. Insights from coxsackie virus B-induced myocarditis in mice deficient in selenium or vitamin E. (9152508)
1997
24
Further investigation on the role of selenium deficiency in the aetiology and pathogenesis of Keshan disease. (9315325)
1997
25
A survey of moniliformin contamination in rice and corn from Keshan disease endemic and non-KSD areas in China. (8719174)
1995
26
Antioxidant status, erythrocyte fatty acids, and mortality from cardiovascular disease and Keshan disease in China. (7956986)
1994
27
Effects of selenium and alpha-tocopherol on liver damage induced by feeding grains from an endemic area of Keshan disease in rats. (7969093)
1994
28
Damage to hepatic thyroxine 5'-deiodination induced by pathogenic factors of Keshan disease and the preventive effects of selenium and vitamin E. (1781930)
1991
29
Common denominators in the etiology and pathology of visceral lesions of cystic fibrosis and Keshan disease. (1702672)
1990
30
The effect of selenium-fortified table salt in the prevention of Keshan disease on a population of 1.05 million. (2096847)
1990
31
Increased sarcolemmal membrane permeability of cardiac muscle cells in rats fed grains cultivated in a Keshan disease endemic area: a study with horseradish peroxidase as a tracer. (2721651)
1989
32
Keshan disease: an entity or not. (3402979)
1988
33
Keshan disease--an endemic mitochondrial cardiomyopathy in China. (2908794)
1988
34
Pancreatic lesions of Keshan disease and its significances. (3129250)
1987
35
Keshan disease: an endemic cardiomyopathy in China. (3997137)
1985
36
The role of selenium in Keshan disease. (6507187)
1984
37
M-mode echocardiographic features of children with Keshan disease. A preliminary observation of 106 cases. (6242288)
1984
38
Nutritional bio-geochemical etiology of Keshan disease. (6416757)
1983
39
Keshan disease-an endemic cardiomyopathy in China. (6412443)
1983
40
Pathology of Keshan disease. A comprehensive review. (6413138)
1983
41
Keshan disease and selenium in China. (7075240)
1982
42
A study of nutritional and bio-geochemical factors in the occurrence and development of Keshan disease. (7131711)
1982
43
Studies on the relations of selenium and Keshan disease. (24272892)
1980
44
On the etiology of Keshan disease: two hypotheses. (110554)
1979
45
Epidemiologic studies on the etiologic relationship of selenium and Keshan disease. (114372)
1979
46
Observations on effect of sodium selenite in prevention of Keshan disease. (114371)
1979
47
The vetosidum in the treatment of Keshan disease. (411634)
1977
48
PATHOLOGIC CHANGES OF THE CONDUCTION SYSTEM OF THE HEART IN 43 CASES OF KESHAN DISEASE. (14191216)
1964

Variations for Keshan Disease

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Expression for genes affiliated with Keshan Disease

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Keshan Disease

Search GEO for disease gene expression data for Keshan Disease.

Pathways for genes affiliated with Keshan Disease

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Sources:
51PathCards, 31KEGG, 61Thomson Reuters, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome, 52PharmGKB
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Pathways related to Keshan Disease according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ICAM1, VCAM1
29.7ICAM1, VCAM1
39.7ICAM1, VCAM1
49.7ICAM1, VCAM1
5
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades61
9.7ICAM1, VCAM1
69.7GPX3, GPX1
79.6ICAM1, HLA-DRB1
89.3CD36, ICAM1, VCAM1
99.3CD36, ICAM1, VCAM1
10
Show member pathways
9.3HLA-DRB1, VCAM1, ICAM1
119.3ICAM1, VCAM1, HLA-DRB1
129.3ICAM1, VCAM1, HLA-DRB1
13
Show member pathways
9.1GPX3, GPX1, GPX8
14
Show member pathways
9.1GPX8, GPX1, GPX3
15
Show member pathways
8.9HLA-DRB1, VCAM1, ICAM1, CD36
16
Show member pathways
Vitamin B12 Metabolism39
8.5GPX4, GPX6, GPX1, GPX3
178.2GPX3, GPX1, GPX6, GPX4, DIO1
18
Show member pathways
thioredoxin pathway39
7.8GPX3, GPX1, GPX6, GPX4, DIO1, ICAM1
19
Show member pathways
7.7GPX3, GPX5, GPX1, GPX6, GPX8
20
Show member pathways
7.4GPX3, GPX5, GPX1, GPX6, GPX4, GPX8
21
Show member pathways
glutathione-mediated detoxification I39
glutathione redox reactions I39
glutathione redox reactions II39
4-hydroxy-2-nonenal detoxification39
Glutathione metabolism61
Glutathione metabolism39
7.4GPX8, GPX4, GPX6, GPX1, GPX5, GPX3

Compounds for genes affiliated with Keshan Disease

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46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Keshan Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
112-hpete4610.2GPX4, GPX1
213-hydroperoxyoctadecadienoic acid4610.2GPX4, VCAM1
312-hydroxyeicosatetraenoic acid4610.1GPX4, GPX1
4linoleic acid hydroperoxide4610.0GPX3, GPX4
5sodium cromoglycate4610.0ICAM1, VCAM1
6selenite4610.0DIO1, GPX4, GPX1
711-deoxy-pge14610.0CD36, ICAM1
8loratadine46 25 1212.0ICAM1, VCAM1
98 methoxypsoralen4610.0ICAM1, VCAM1
10selenomethionine46 2511.0GPX3, GPX4
11sele469.9VCAM1, ICAM1
12helenalin469.8ICAM1, VCAM1
13hydroxide469.8GPX3, GPX4
14gliclazide46 52 1211.8ICAM1, VCAM1
15hcec469.7ICAM1, VCAM1
16malondialdehyde469.7GPX4, GPX1, GPX3
17budesonide46 52 1211.7VCAM1, ICAM1, CD36
18homocysteine46 2510.7VCAM1, GPX1, GPX3
19acetone469.6CD36, ICAM1
20troglitazone46 30 62 1212.6CD36, ICAM1, VCAM1
21cytochalasin d46 6210.6VCAM1, ICAM1, CD36
228-isoprostane469.6ICAM1, VCAM1, GPX3
23herbimycin a46 6210.6CD36, ICAM1, VCAM1
24hyaluronic acid46 2510.5VCAM1, ICAM1, CD36
25selenocysteine46 25 1211.5DIO1, GPX4, GPX1, GPX3
26n acetylcysteine469.5ICAM1, VCAM1, GPX4, GPX1
27manganese superoxide469.4GPX3, GPX1, GPX4, VCAM1
28vitamin-e469.4GPX3, GPX1, GPX4, VCAM1
29pge2469.3GPX4, VCAM1, ICAM1, CD36
30superoxide46 2510.3GPX3, GPX1, GPX4, VCAM1
31nadph46 2510.3VCAM1, GPX4, GPX1, GPX5
32cysteine469.2GPX1, GPX4, VCAM1, DIO1, CD36
33ascorbic acid46 2510.2GPX3, GPX4, ICAM1, CD36
34phosphatidylcholine469.2VCAM1, GPX4, GPX3
35alpha tocopherol469.0GPX3, GPX1, GPX4, VCAM1, CD36
36cholesterol46 30 25 1212.0GPX3, GPX1, GPX4, VCAM1
37h2o2468.9GPX3, GPX1, GPX4, ICAM1, CD36
38oxygen46 259.9GPX3, GPX1, GPX4, VCAM1, ICAM1
39lipid468.6VCAM1, GPX4, GPX1, GPX5, GPX3
40dexamethasone46 52 30 1211.5GPX3, VCAM1, ICAM1, CD36
4115(S)-HETE258.3GPX4, GPX3, GPX5, GPX1, GPX6
425-HETE258.3GPX3, GPX5, GPX1, GPX6, GPX4
435(S)-Hydroperoxyeicosatetraenoic acid258.3GPX3, GPX5, GPX1, GPX6, GPX4
445-hpete46 259.3GPX4, GPX6, GPX1, GPX5, GPX3
45Oxidized glutathione258.3GPX3, GPX5, GPX1, GPX6, GPX4
4615(S)-HPETE258.3GPX3, GPX5, GPX1, GPX6, GPX4
47Hydrogen peroxide258.3GPX3, GPX5, GPX1, GPX6, GPX4
48Water258.3GPX3, GPX5, GPX1, GPX6, GPX4
49selenium46 259.0GPX3, GPX5, GPX1, GPX6, GPX4, DIO1
50Glutathione25 128.8GPX3, GPX5, GPX1, GPX6, GPX4, GPX8

GO Terms for genes affiliated with Keshan Disease

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17Gene Ontology
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Cellular components related to Keshan Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle membraneGO:0306669.7CD36, HLA-DRB1
2external side of plasma membraneGO:0098978.6CD36, ICAM1, VCAM1, HLA-DRB1

Biological processes related to Keshan Disease according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1lipoxygenase pathwayGO:01937210.1GPX4, GPX1
2response to nicotineGO:03509410.0GPX1, VCAM1
3response to lipid hydroperoxideGO:0069829.9GPX1, GPX3
4membrane to membrane dockingGO:0226149.9VCAM1, ICAM1
5glutathione metabolic processGO:0067499.9GPX4, GPX1
6leukocyte cell-cell adhesionGO:0071599.9ICAM1, VCAM1
7heterophilic cell-cell adhesionGO:0071579.8ICAM1, VCAM1
8agingGO:0075689.7GPX1, GPX4, VCAM1
9cellular response to glucose stimulusGO:0713339.7VCAM1, ICAM1
10cellular response to tumor necrosis factorGO:0713569.7ICAM1, VCAM1
11hydrogen peroxide catabolic processGO:0427449.6GPX4, GPX1, GPX3
12response to ionizing radiationGO:0102129.6ICAM1, VCAM1
13arachidonic acid metabolic processGO:0193699.6GPX4, GPX1
14interferon-gamma-mediated signaling pathwayGO:0603339.5ICAM1, VCAM1, HLA-DRB1
15cytokine-mediated signaling pathwayGO:0192219.4ICAM1, VCAM1, HLA-DRB1
16response to oxidative stressGO:0069798.8GPX8, GPX6, GPX5

Molecular functions related to Keshan Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione bindingGO:0432959.9GPX4, GPX1
2phospholipid-hydroperoxide glutathione peroxidase activityGO:0470669.6GPX4, GPX1
3selenium bindingGO:0084308.9GPX3, GPX1, GPX4, DIO1
4glutathione peroxidase activityGO:0046027.4GPX8, GPX4, GPX6, GPX1, GPX5, GPX3

Products for genes affiliated with Keshan Disease

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  • Antibodies
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  • Lysates
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Sources for Keshan Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet