MCID: KSH001
MIFTS: 33

Keshan Disease malady

Categories: Rare diseases, Metabolic diseases

Aliases & Classifications for Keshan Disease

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Aliases & Descriptions for Keshan Disease:

Name: Keshan Disease 11 48 13 68
Caused by Deficiency of Selenium in the Diet 48
 
Enlarged Heart and Poor Heart Function 48

Classifications:



External Ids:

Disease Ontology11 DOID:0050083

Summaries for Keshan Disease

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Wikipedia:71 Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium... more...

MalaCards based summary: Keshan Disease, also known as caused by deficiency of selenium in the diet, is related to cardiomyopathy and pancreatitis. An important gene associated with Keshan Disease is GPX1 (Glutathione Peroxidase 1), and among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and Cardiomyocyte Differentiation through BMP Receptors. Affiliated tissues include heart, pancreatic islet and liver, and related mouse phenotypes are Increased shRNA abundance (Z-score > 2) and immune system.

Related Diseases for Keshan Disease

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Diseases related to Keshan Disease via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1cardiomyopathy10.2
2pancreatitis10.0
3cystic fibrosis9.9
4dilated cardiomyopathy9.9
5mitochondrial cardiomyopathy9.9
6hepatitis9.7
7heart disease9.7
8myocarditis9.7
9endothrix infectious disease8.8BMP5, BMP7, GPX1, HLA-DOA, HLA-DQA1, HLA-DRA

Graphical network of diseases related to Keshan Disease:



Diseases related to keshan disease

Symptoms & Phenotypes for Keshan Disease

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GenomeRNAi Phenotypes related to Keshan Disease according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-1928.7BMP7, GPX1, SCN5A

MGI Mouse Phenotypes related to Keshan Disease according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.4BMP5, BMP7, GPX1, HLA-DOA, HLA-DQA1, TNFSF15

Drugs & Therapeutics for Keshan Disease

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Drugs for Keshan Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Seleniumapproved, vet_approvedPhase 31807782-49-2
Synonyms:
Selanediide
Selen
Selenide
Selenide(2-)
Selenio
 
Selenium
Selenium elemental
Selenium ion (Se2+)
Selenium metallicum
Selenium, elemental
Sélénium
2Sodium SelenitePhase 318
3Trace ElementsPhase 36001
4Protective AgentsPhase 37443
5MicronutrientsPhase 36001
6AntioxidantsPhase 33050

Interventional clinical trials:

idNameStatusNCT IDPhase
1Selenium Treatment and Chagasic Cardiopathy (STCC)RecruitingNCT00875173Phase 3

Search NIH Clinical Center for Keshan Disease

Genetic Tests for Keshan Disease

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Anatomical Context for Keshan Disease

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MalaCards organs/tissues related to Keshan Disease:

36
Heart, Pancreatic islet, Liver

Publications for Keshan Disease

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Articles related to Keshan Disease:

(show top 50)    (show all 56)
idTitleAuthorsYear
1
Metabolism of arachidonic acid by the cytochrome P450 enzyme in patients with chronic Keshan disease and dilated cardiomyopathy. (26893848)
2016
2
An approach to assessment of Keshan disease elimination at the township level. (27821502)
2016
3
TLR2-ICAM1-Gadd45I+ axis mediates the epigenetic effect of selenium on DNA methylation and gene expression in Keshan disease. (24811888)
2014
4
H558R polymorphism in SCN5A is associated with Keshan disease and QRS prolongation in Keshan disease patients. (25177937)
2014
5
Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease. (24384427)
2014
6
Serum biomarkers of Keshan disease assessed using a protein profiling approach based on ClinProt technique. (24841853)
2014
7
Keshan disease, selenium deficiency, and the selenoproteome. (24785212)
2014
8
Long-term prognostic value of major and minor ECG abnormalities in latent Keshan disease with suspect chronic Keshan disease. (24975014)
2014
9
The prevalence of Keshan disease in China. (23218571)
2013
10
Oxidative stress is involved in the pathogenesis of Keshan disease (an endemic dilated cardiomyopathy) in China. (24062877)
2013
11
An original discovery: selenium deficiency and Keshan disease (an endemic heart disease). (22705420)
2012
12
The effect of DHEA treatment on the oxidative stress and myocardial fibrosis induced by Keshan disease pathogenic factors. (21602037)
2011
13
Is selenium deficiency really the cause of Keshan disease? (20574681)
2011
14
Analysis of glutathione peroxidase 1 gene polymorphism and Keshan disease in Heilongjiang Province, China. (22180033)
2011
15
Suboptimal selenium supply--a continuing problem in Keshan disease areas in Heilongjiang province. (21253891)
2011
16
Chronic exposure to cereal mycotoxin likely citreoviridin may be a trigger for Keshan disease mainly through oxidative stress mechanism. (20034747)
2010
17
Polymorphisms in the glutathione peroxidase-1 gene associated with increased risk of Keshan disease]. (21055077)
2010
18
Selenium level surveillance for the year 2007 of Keshan disease in endemic areas and analysis on surveillance results between 2003 and 2007. (20180046)
2010
19
Circulating adhesion molecules in patients with Keshan disease and their relationship with Coxsackie B virus infection. (19399399)
2009
20
The study on relation of HLA-DRB1 gene polymorphism to Keshan disease and its association and linkage in the core families]. (17285554)
2007
21
Keshan disease and mitochondrial cardiomyopathy. (17312989)
2006
22
Coxsackievirus B3 infection and its mutation in Keshan disease. (15484304)
2004
23
HIV-associated cardiomyopathy is not Keshan disease. (12042392)
2002
24
Fulminant heart failure due to selenium deficiency cardiomyopathy (Keshan disease). (11848134)
2002
25
Selenite inhibition of Coxsackie virus B5 replication: implications on the etiology of Keshan disease. (11878751)
2002
26
Multifocal myocardial necrosis: a distinctive cardiac lesion in cystic fibrosis, lipomatous pancreatic atrophy, and Keshan disease. (12056507)
2002
27
High prevalence of enteroviral genomic sequences in myocardium from cases of endemic cardiomyopathy (Keshan disease) in China. (10814633)
2000
28
Morphological studies of myocardial fibrosis in different types of Keshan disease]. (11244934)
1998
29
Alterations in rat pancreatic islet beta cells induced by Keshan disease pathogenic factors: protective action of selenium and vitamin E. (9550538)
1998
30
Further investigation on the role of selenium deficiency in the aetiology and pathogenesis of Keshan disease. (9315325)
1997
31
Interacting nutritional and infectious etiologies of Keshan disease. Insights from coxsackie virus B-induced myocarditis in mice deficient in selenium or vitamin E. (9152508)
1997
32
A survey of moniliformin contamination in rice and corn from Keshan disease endemic and non-KSD areas in China. (8719174)
1995
33
Antioxidant status, erythrocyte fatty acids, and mortality from cardiovascular disease and Keshan disease in China. (7956986)
1994
34
Effects of selenium and alpha-tocopherol on liver damage induced by feeding grains from an endemic area of Keshan disease in rats. (7969093)
1994
35
Damage to hepatic thyroxine 5'-deiodination induced by pathogenic factors of Keshan disease and the preventive effects of selenium and vitamin E. (1781930)
1991
36
Common denominators in the etiology and pathology of visceral lesions of cystic fibrosis and Keshan disease. (1702672)
1990
37
The effect of selenium-fortified table salt in the prevention of Keshan disease on a population of 1.05 million. (2096847)
1990
38
Increased sarcolemmal membrane permeability of cardiac muscle cells in rats fed grains cultivated in a Keshan disease endemic area: a study with horseradish peroxidase as a tracer. (2721651)
1989
39
Keshan disease--an endemic mitochondrial cardiomyopathy in China. (2908794)
1988
40
Keshan disease: an entity or not. (3402979)
1988
41
Pancreatic lesions of Keshan disease and its significances. (3129250)
1987
42
Selenium and cardiomyopathy (Keshan disease). (3776583)
1986
43
Keshan disease: an endemic cardiomyopathy in China. (3997137)
1985
44
M-mode echocardiographic features of children with Keshan disease. A preliminary observation of 106 cases. (6242288)
1984
45
The role of selenium in Keshan disease. (6507187)
1984
46
Pathology of Keshan disease. A comprehensive review. (6413138)
1983
47
Keshan disease-an endemic cardiomyopathy in China. (6412443)
1983
48
Nutritional bio-geochemical etiology of Keshan disease. (6416757)
1983
49
A study of nutritional and bio-geochemical factors in the occurrence and development of Keshan disease. (7131711)
1982
50
Keshan disease and selenium in China. (7075240)
1982

Variations for Keshan Disease

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Expression for genes affiliated with Keshan Disease

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Search GEO for disease gene expression data for Keshan Disease.

Pathways for genes affiliated with Keshan Disease

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Pathways related to Keshan Disease according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathwaysScoreTop Affiliating Genes
19.5HLA-DRA, TNFSF15
29.2BMP5, BMP7
3
Show member pathways
9.1HLA-DOA, HLA-DQA1, HLA-DRA
4
Show member pathways
9.1HLA-DOA, HLA-DQA1, HLA-DRA
5
Show member pathways
9.1HLA-DOA, HLA-DQA1, HLA-DRA
6
Show member pathways
9.1HLA-DOA, HLA-DQA1, HLA-DRA
7
Show member pathways
9.1HLA-DOA, HLA-DQA1, HLA-DRA
89.1HLA-DOA, HLA-DQA1, HLA-DRA
99.1HLA-DOA, HLA-DQA1, HLA-DRA
109.1HLA-DOA, HLA-DQA1, HLA-DRA
119.1HLA-DOA, HLA-DQA1, HLA-DRA
129.1HLA-DOA, HLA-DQA1, HLA-DRA
139.1HLA-DOA, HLA-DQA1, HLA-DRA
149.1HLA-DOA, HLA-DQA1, HLA-DRA
159.1HLA-DOA, HLA-DQA1, HLA-DRA
169.1HLA-DOA, HLA-DQA1, HLA-DRA

GO Terms for genes affiliated with Keshan Disease

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Cellular components related to Keshan Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:003066910.2HLA-DQA1, HLA-DRA
2endocytic vesicle membraneGO:003066610.2HLA-DQA1, HLA-DRA
3ER to Golgi transport vesicle membraneGO:001250710.2HLA-DQA1, HLA-DRA
4integral component of lumenal side of endoplasmic reticulum membraneGO:007155610.2HLA-DQA1, HLA-DRA
5endosome membraneGO:00100089.8HLA-DOA, HLA-DQA1, HLA-DRA
6lysosomal membraneGO:00057659.8HLA-DOA, HLA-DQA1, HLA-DRA
7lysosomeGO:00057649.6HLA-DOA, HLA-DQA1, HLA-DRA
8MHC class II protein complexGO:00426139.6HLA-DOA, HLA-DQA1, HLA-DRA
9transport vesicle membraneGO:00306589.5HLA-DQA1, HLA-DRA

Biological processes related to Keshan Disease according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.4BMP5, GPX1
2interferon-gamma-mediated signaling pathwayGO:006033310.1HLA-DQA1, HLA-DRA
3positive regulation of epithelial cell proliferationGO:005067910.0BMP5, SCN5A
4allantois developmentGO:190506910.0BMP5, BMP7
5cardiac muscle tissue developmentGO:004873810.0BMP5, BMP7
6cardiac septum morphogenesisGO:006041110.0BMP5, BMP7
7cartilage developmentGO:00512169.9BMP5, BMP7
8chorio-allantoic fusionGO:00607109.9BMP5, BMP7
9endocardial cushion formationGO:00032729.9BMP5, BMP7
10heart trabecula morphogenesisGO:00613849.9BMP5, BMP7
11hindbrain developmentGO:00309029.9BMP5, BMP7
12neural fold elevation formationGO:00215029.9BMP5, BMP7
13pattern specification processGO:00073899.9BMP5, BMP7
14pericardium morphogenesisGO:00033449.9BMP5, BMP7
15pharyngeal system developmentGO:00600379.9BMP5, BMP7
16positive regulation of dendrite developmentGO:19000069.8BMP5, BMP7
17antigen processing and presentationGO:00198829.8HLA-DOA, HLA-DQA1, HLA-DRA
18antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.8HLA-DOA, HLA-DQA1, HLA-DRA
19antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:00025049.8HLA-DOA, HLA-DQA1, HLA-DRA
20positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.8BMP5, BMP7
21SMAD protein signal transductionGO:00603959.7BMP5, BMP7
22odontogenesis of dentin-containing toothGO:00424759.7BMP7, SCN5A
23T cell costimulationGO:00312959.5HLA-DQA1, HLA-DRA
24immune responseGO:00069559.3HLA-DOA, HLA-DQA1, HLA-DRA, TNFSF15

Molecular functions related to Keshan Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complex bindingGO:002302610.2HLA-DOA, HLA-DRA
2peptide antigen bindingGO:00426059.9HLA-DQA1, HLA-DRA
3BMP receptor bindingGO:00707009.9BMP5, BMP7
4MHC class II receptor activityGO:00323959.6HLA-DOA, HLA-DQA1, HLA-DRA
5cytokine activityGO:00051259.2BMP5, BMP7, TNFSF15
6transforming growth factor beta receptor bindingGO:00051609.2BMP5, BMP7

Sources for Keshan Disease

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet