MCID: KSH001
MIFTS: 30

Keshan Disease malady

Categories: Rare diseases, Metabolic diseases

Aliases & Classifications for Keshan Disease

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Aliases & Descriptions for Keshan Disease:

Name: Keshan Disease 11 46 13 66
Caused by Deficiency of Selenium in the Diet 46
 
Enlarged Heart and Poor Heart Function 46

Classifications:



External Ids:

Disease Ontology11 DOID:0050083

Summaries for Keshan Disease

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Wikipedia:69 Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium... more...

MalaCards based summary: Keshan Disease, also known as caused by deficiency of selenium in the diet, is related to cardiomyopathy and pancreatitis. An important gene associated with Keshan Disease is GPX1 (Glutathione Peroxidase 1), and among its related pathways are CTLA4 Signaling and Rheumatoid arthritis. Affiliated tissues include heart, pancreatic islet and liver.

Related Diseases for Keshan Disease

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Diseases related to Keshan Disease via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1cardiomyopathy10.4
2pancreatitis10.1
3cystic fibrosis10.0
4dilated cardiomyopathy10.0
5mitochondrial cardiomyopathy10.0
6hepatitis9.9
7heart disease9.9
8myocarditis9.9
9ectothrix infectious disease7.2BMP5, BMP7, GPX1, HLA-DOA, HLA-DRA, SCN5A

Graphical network of diseases related to Keshan Disease:



Diseases related to keshan disease

Symptoms for Keshan Disease

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Drugs & Therapeutics for Keshan Disease

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Drugs for Keshan Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
seleniumPhase 31717782-49-2
Synonyms:
Selanediide
Selenide
 
Selenide(2-)
Selenium
Selenium ion (Se2+)

Interventional clinical trials:

idNameStatusNCT IDPhase
1Selenium Treatment and Chagasic Cardiopathy (STCC)RecruitingNCT00875173Phase 3

Search NIH Clinical Center for Keshan Disease

Genetic Tests for Keshan Disease

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Anatomical Context for Keshan Disease

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MalaCards organs/tissues related to Keshan Disease:

34
Heart, Pancreatic islet, Liver

Animal Models for Keshan Disease or affiliated genes

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Publications for Keshan Disease

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Articles related to Keshan Disease:

(show top 50)    (show all 55)
idTitleAuthorsYear
1
Metabolism of arachidonic acid by the cytochrome P450 enzyme in patients with chronic Keshan disease and dilated cardiomyopathy. (26893848)
2016
2
Keshan disease, selenium deficiency, and the selenoproteome. (24785212)
2014
3
Serum biomarkers of Keshan disease assessed using a protein profiling approach based on ClinProt technique. (24841853)
2014
4
Long-term prognostic value of major and minor ECG abnormalities in latent Keshan disease with suspect chronic Keshan disease. (24975014)
2014
5
Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease. (24384427)
2014
6
H558R polymorphism in SCN5A is associated with Keshan disease and QRS prolongation in Keshan disease patients. (25177937)
2014
7
The prevalence of Keshan disease in China. (23218571)
2013
8
Oxidative stress is involved in the pathogenesis of Keshan disease (an endemic dilated cardiomyopathy) in China. (24062877)
2013
9
An original discovery: selenium deficiency and Keshan disease (an endemic heart disease). (22705420)
2012
10
Analysis of glutathione peroxidase 1 gene polymorphism and Keshan disease in Heilongjiang Province, China. (22180033)
2011
11
The effect of DHEA treatment on the oxidative stress and myocardial fibrosis induced by Keshan disease pathogenic factors. (21602037)
2011
12
Suboptimal selenium supply--a continuing problem in Keshan disease areas in Heilongjiang province. (21253891)
2011
13
Is selenium deficiency really the cause of Keshan disease? (20574681)
2011
14
Selenium level surveillance for the year 2007 of Keshan disease in endemic areas and analysis on surveillance results between 2003 and 2007. (20180046)
2010
15
Chronic exposure to cereal mycotoxin likely citreoviridin may be a trigger for Keshan disease mainly through oxidative stress mechanism. (20034747)
2010
16
Polymorphisms in the glutathione peroxidase-1 gene associated with increased risk of Keshan disease]. (21055077)
2010
17
Circulating adhesion molecules in patients with Keshan disease and their relationship with Coxsackie B virus infection. (19399399)
2009
18
The study on relation of HLA-DRB1 gene polymorphism to Keshan disease and its association and linkage in the core families]. (17285554)
2007
19
Keshan disease and mitochondrial cardiomyopathy. (17312989)
2006
20
Coxsackievirus B3 infection and its mutation in Keshan disease. (15484304)
2004
21
Fulminant heart failure due to selenium deficiency cardiomyopathy (Keshan disease). (11848134)
2002
22
Selenite inhibition of Coxsackie virus B5 replication: implications on the etiology of Keshan disease. (11878751)
2002
23
Multifocal myocardial necrosis: a distinctive cardiac lesion in cystic fibrosis, lipomatous pancreatic atrophy, and Keshan disease. (12056507)
2002
24
High prevalence of enteroviral genomic sequences in myocardium from cases of endemic cardiomyopathy (Keshan disease) in China. (10814633)
2000
25
Alterations in rat pancreatic islet beta cells induced by Keshan disease pathogenic factors: protective action of selenium and vitamin E. (9550538)
1998
26
Morphological studies of myocardial fibrosis in different types of Keshan disease]. (11244934)
1998
27
Interacting nutritional and infectious etiologies of Keshan disease. Insights from coxsackie virus B-induced myocarditis in mice deficient in selenium or vitamin E. (9152508)
1997
28
A survey of moniliformin contamination in rice and corn from Keshan disease endemic and non-KSD areas in China. (8719174)
1995
29
Antioxidant status, erythrocyte fatty acids, and mortality from cardiovascular disease and Keshan disease in China. (7956986)
1994
30
Damage to hepatic thyroxine 5'-deiodination induced by pathogenic factors of Keshan disease and the preventive effects of selenium and vitamin E. (1781930)
1991
31
Common denominators in the etiology and pathology of visceral lesions of cystic fibrosis and Keshan disease. (1702672)
1990
32
The effect of selenium-fortified table salt in the prevention of Keshan disease on a population of 1.05 million. (2096847)
1990
33
Increased sarcolemmal membrane permeability of cardiac muscle cells in rats fed grains cultivated in a Keshan disease endemic area: a study with horseradish peroxidase as a tracer. (2721651)
1989
34
Keshan disease: an entity or not. (3402979)
1988
35
Pancreatic lesions of Keshan disease and its significances. (3129250)
1987
36
Selenium and cardiomyopathy (Keshan disease). (3776583)
1986
37
Keshan disease: an endemic cardiomyopathy in China. (3997137)
1985
38
The role of selenium in Keshan disease. (6507187)
1984
39
M-mode echocardiographic features of children with Keshan disease. A preliminary observation of 106 cases. (6242288)
1984
40
Keshan disease-an endemic cardiomyopathy in China. (6412443)
1983
41
Pathology of Keshan disease. A comprehensive review. (6413138)
1983
42
Nutritional bio-geochemical etiology of Keshan disease. (6416757)
1983
43
A study of nutritional and bio-geochemical factors in the occurrence and development of Keshan disease. (7131711)
1982
44
Keshan disease and selenium in China. (7075240)
1982
45
Studies on the relations of selenium and Keshan disease. (24272892)
1980
46
Epidemiologic studies on the etiologic relationship of selenium and Keshan disease. (114372)
1979
47
Observations on effect of sodium selenite in prevention of Keshan disease. (114371)
1979
48
On the etiology of Keshan disease: two hypotheses. (110554)
1979
49
The vetosidum in the treatment of Keshan disease. (411634)
1977
50
PATHOLOGIC CHANGES OF THE CONDUCTION SYSTEM OF THE HEART IN 43 CASES OF KESHAN DISEASE. (14191216)
1964

Variations for Keshan Disease

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Expression for genes affiliated with Keshan Disease

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Search GEO for disease gene expression data for Keshan Disease.

Pathways for genes affiliated with Keshan Disease

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GO Terms for genes affiliated with Keshan Disease

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Cellular components related to Keshan Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.5HLA-DOA, HLA-DRA
2membrane-bounded vesicleGO:00319889.2BMP5, BMP7

Biological processes related to Keshan Disease according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.0BMP5, GPX1
2SMAD protein signal transductionGO:006039510.0BMP5, BMP7
3growthGO:004000710.0BMP5, BMP7
4positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.9BMP5, BMP7
5positive regulation of dendrite developmentGO:19000069.9BMP5, BMP7
6cartilage developmentGO:00512169.7BMP5, BMP7
7antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.7HLA-DOA, HLA-DRA
8pattern specification processGO:00073899.6BMP5, BMP7
9BMP signaling pathwayGO:00305099.6BMP5, BMP7
10odontogenesis of dentin-containing toothGO:00424759.3BMP7, SCN5A
11ossificationGO:00015039.2BMP5, BMP7
12positive regulation of epithelial cell proliferationGO:00506799.1BMP5, SCN5A
13immune responseGO:00069558.9HLA-DOA, HLA-DRA, TNFSF15

Molecular functions related to Keshan Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:003239510.1HLA-DOA, HLA-DRA
2BMP receptor bindingGO:00707009.9BMP5, BMP7
3transforming growth factor beta receptor bindingGO:00051609.9BMP5, BMP7
4MHC class II protein complex bindingGO:00230269.9HLA-DOA, HLA-DRA
5cytokine activityGO:00051258.9BMP5, BMP7, TNFSF15

Sources for Keshan Disease

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet