MCID: KSH001
MIFTS: 31

Keshan Disease malady

Categories: Rare diseases, Metabolic diseases

Aliases & Classifications for Keshan Disease

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Aliases & Descriptions for Keshan Disease:

Name: Keshan Disease 10 45 12 65
Caused by Deficiency of Selenium in the Diet 45
 
Enlarged Heart and Poor Heart Function 45

Classifications:



External Ids:

Disease Ontology10 DOID:0050083
UMLS65 C0268095

Summaries for Keshan Disease

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Wikipedia:68 Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium... more...

MalaCards based summary: Keshan Disease, also known as caused by deficiency of selenium in the diet, is related to asthma and lymphoma. An important gene associated with Keshan Disease is GPX1 (Glutathione Peroxidase 1), and among its related pathways are MHC class II antigen presentation and CTLA4 Signaling. Affiliated tissues include heart, t cells and lung.

Related Diseases for Keshan Disease

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Graphical network of the top 20 diseases related to Keshan Disease:



Diseases related to keshan disease

Symptoms for Keshan Disease

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Drugs & Therapeutics for Keshan Disease

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Drugs for Keshan Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Sodium SelenitePhase 316
2Trace ElementsPhase 33900
3
SeleniumPhase 31667782-49-2
Synonyms:
Selanediide
Selenide
 
Selenide(2-)
Selenium
Selenium ion (Se2+)
4Protective AgentsPhase 35651
5MicronutrientsPhase 33901
6AntioxidantsPhase 32442

Interventional clinical trials:

idNameStatusNCT IDPhase
1Selenium Treatment and Chagasic Cardiopathy (STCC)RecruitingNCT00875173Phase 3

Search NIH Clinical Center for Keshan Disease

Genetic Tests for Keshan Disease

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Anatomical Context for Keshan Disease

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MalaCards organs/tissues related to Keshan Disease:

33
Heart, T cells, Lung, Neutrophil, Breast, Endothelial, Testes

Animal Models for Keshan Disease or affiliated genes

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MGI Mouse Phenotypes related to Keshan Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Keshan Disease

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Articles related to Keshan Disease:

(show top 50)    (show all 54)
idTitleAuthorsYear
1
Association of the XRCC1 c.1178G>A genetic polymorphism with lung cancer risk in Chinese. (24935603)
2014
2
Effects Of A Selective Histamine H4r Antagonist On Inflammation In A Model Of Carrageenan-Induced Pleurisy In The Rat. (23978101)
2013
3
Preliminary analysis of age of illness onset effects on symptom profiles in major depressive disorder. (23420677)
2013
4
IL-33 independently induces eosinophilic pericarditis and cardiac dilation: ST2 improves cardiac function. (22454393)
2012
5
A novel splice site mutation in gene C2orf37 underlying Woodhouse-Sakati syndrome (WSS) in a consanguineous family of Pakistani origin. (21963443)
2011
6
Malonyl-CoA synthetase, encoded by ACYL ACTIVATING ENZYME13, is essential for growth and development of Arabidopsis. (21642549)
2011
7
Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients. (21451124)
2011
8
Thioridazine induces apoptosis of multidrug-resistant mouse lymphoma cells transfected with the human ABCB1 and inhibits the expression of P-glycoprotein. (22199281)
2011
9
Association of CYP19 and ESR1 pleiotropic genes with human longevity. (20819792)
2011
10
NF-E2: a novel regulator of alpha-hemoglobin stabilizing protein gene expression. (21232177)
2010
11
Rosai-Dorfman disease. (21103807)
2010
12
Osteopoikilosis. (20886307)
2010
13
LFA-1 activity state on dendritic cells regulates contact duration with T cells and promotes T-cell priming. (20530790)
2010
14
Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. (20531390)
2010
15
Fragile X mental retardation protein FMRP binds mRNAs in the nucleus. (18936162)
2009
16
Prophylaxis with prothrombin complex concentrate in four children with severe congenital factor X deficiency. (19149864)
2009
17
Histopathological criteria and selection algorithms for BRCA1 genetic testing. (19215791)
2009
18
Involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis(y) (CD174) in first endothelial cell-cell contacts during angiogenesis. (18205178)
2008
19
Angiogenesis in eye disease: immunity gained or immunity lost? (18297288)
2008
20
Adaptive autophagy in Alexander disease-affected astrocytes. (18414043)
2008
21
Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer. (18719384)
2008
22
Is UCP2 gene polymorphism associated with decreased resting energy expenditure in nondialyzed chronic kidney disease patients? (18940651)
2008
23
Myostatin inhibition by a follistatin-derived peptide ameliorates the pathophysiology of muscular dystrophy model mice. (19108572)
2008
24
The Meckel-Gruber syndrome gene, MKS3, is mutated in Joubert syndrome. (17160906)
2007
25
Interactions between Sox10, Edn3 and Ednrb during enteric nervous system and melanocyte development. (16650841)
2006
26
Progesterone inhibits the estrogen-induced phosphoinositide 3-kinase-->AKT-->GSK-3beta-->cyclin D1-->pRB pathway to block uterine epithelial cell proliferation. (15845746)
2005
27
Shear stress regulates HUVEC hydraulic conductivity by occludin phosphorylation. (16341921)
2005
28
A role for caveolae in cell migration. (15576483)
2004
29
Clinical phenotypes associated with DISC1, a candidate gene for schizophrenia. (15184103)
2004
30
Role of tumor necrosis factor-related apoptosis-inducing ligand in interferon-induced apoptosis in human bladder cancer cells. (15604261)
2004
31
Kinetics and energetics of the binding between barley alpha-amylase/subtilisin inhibitor and barley alpha-amylase 2 analyzed by surface plasmon resonance and isothermal titration calorimetry. (12578360)
2003
32
New component of the limbic system: Marginal division of the neostriatum that links the limbic system to the basal nucleus of Meynert. (12584733)
2003
33
A case of neurosarcoidosis presenting with multiple cranial nerve palsy. (12839373)
2003
34
Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation. (12388545)
2002
35
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1. (12160938)
2002
36
Expression and antitumor effects of TRAIL in human cholangiocarcinoma. (10960444)
2000
37
Functional deficiencies of components of the MHC class I antigen pathway in human tumors of epithelial origin. (10933198)
2000
38
Multiple signaling pathways mediate interleukin-4-induced 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene expression in human breast cancer cells. (10674396)
2000
39
Neutrophilic cell production by combination of stem cell factor and thrombopoietin from CD34(+) cord blood cells in long-term serum-deprived liquid culture. (9885212)
1999
40
Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing. (9396774)
1997
41
ASP stimulates glucose transport in cultured human adipocytes. (9130021)
1997
42
Vasodilator hormonal agents in chronic heart failure: effect of angiotensin-converting enzyme inhibitors]. (9430932)
1997
43
The role of pre-operative thallium-technetium subtraction scintigraphy in the surgical management of patients with solitary parathyroid adenoma. (8641112)
1996
44
Benign fibrous mesothelioma: report of a case. (8669882)
1995
45
Sequential estrogen-progestin addition to gonadotropin-releasing hormone agonist suppression for the chronic treatment of ovarian hyperandrogenism: a pilot study. (7989480)
1994
46
Malignant fibrous histiocytoma of the glans penis. (2158757)
1990
47
The effect of transforming growth factor-beta 1 on glycosaminoglycan production by human marrow cultures. (2120082)
1990
48
Central pontine myelinolysis complicating hyponatraemia. (3614073)
1987
49
Endotracheal tube modification for therapy of right-sided pulmonary interstitial emphysema. (3780120)
1986
50
Zollinger-Ellison syndrome with esophagitis and Barrett mucosa. (6624733)
1983

Variations for Keshan Disease

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Expression for genes affiliated with Keshan Disease

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Search GEO for disease gene expression data for Keshan Disease.

Pathways for genes affiliated with Keshan Disease

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GO Terms for genes affiliated with Keshan Disease

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Biological processes related to Keshan Disease according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.9BMP5, GPX1
2BMP signaling pathwayGO:00305099.8BMP5, BMP7
3SMAD protein signal transductionGO:00603959.7BMP5, BMP7
4pattern specification processGO:00073899.7BMP5, BMP7
5positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.6BMP5, BMP7
6growthGO:00400079.6BMP5, BMP7
7ossificationGO:00015039.5BMP5, BMP7
8positive regulation of dendrite developmentGO:19000069.5BMP5, BMP7
9skeletal system developmentGO:00015019.4BMP5, BMP7
10regulation of apoptotic processGO:00429819.2BMP5, BMP7

Sources for Keshan Disease

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet