MCID: KSH001
MIFTS: 42

Keshan Disease malady

Rare diseases category
Download this MalaCard

Summaries for Keshan Disease

About this section
Sources:
65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium... more...

MalaCards: Keshan Disease, also known as caused by deficiency of selenium in the diet, is related to pancreatitis and cystic fibrosis. An important gene associated with Keshan Disease is DIO1 (deiodinase, iodothyronine, type I), and among its related pathways are African trypanosomiasis and Immune response MIF mediated glucocorticoid regulation. The compounds 12-hpete and 13-hydroperoxyoctadecadienoic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and pancreatic islet, and related mouse phenotypes are homeostasis/metabolism and growth/size/body.

Aliases & Classifications for Keshan Disease

About this section
Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 62UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

keshan disease 8 43 10 62
caused by deficiency of selenium in the diet 43
enlarged heart and poor heart function 43


External Ids:

Disease Ontology8 DOID:0050083

Related Diseases for Keshan Disease

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Keshan Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis10.3
2cystic fibrosis10.2
3mitochondrial cardiomyopathy10.2
4acute chest syndrome10.1VCAM1
5dilated cardiomyopathy10.1
6hepatitis10.1
7myocarditis10.1
8thyroiditis10.1HLA-DRB1
9rheumatoid vasculitis10.0ICAM1, VCAM1
10arteriosclerosis obliterans10.0ICAM1, VCAM1
11immunoglobulin a vasculitis10.0ICAM1, VCAM1
12vascular disease10.0GPX4, GPX1, GPX5
13inclusion body myositis10.0VCAM1, ICAM1
14cork-handlers' disease10.0GPX5, GPX1, GPX4
15leukostasis10.0VCAM1, ICAM1
16toxic encephalopathy10.0GPX4, GPX1, GPX5
17prion disease10.0GPX4, GPX1, GPX5
18oral lichen planus10.0ICAM1, VCAM1
19hyperhomocysteinemia10.0GPX1, VCAM1
20arteriosclerosis10.0ICAM1, VCAM1
21proliferative diabetic retinopathy10.0VCAM1, ICAM1
22rhinitis10.0VCAM1, ICAM1
23lupus nephritis10.0VCAM1, ICAM1
24dermatomyositis10.0VCAM1, ICAM1
25polymyositis10.0ICAM1, VCAM1
26myositis10.0VCAM1, ICAM1
27diabetic retinopathy10.0ICAM1, VCAM1
28coronary artery disease10.0ICAM1, VCAM1, GPX1
29arthritis10.0ICAM1, HLA-DRB1
30synovitis10.0VCAM1, ICAM1
31pre-eclampsia10.0GPX3, VCAM1, ICAM1
32galactosemia10.0GPX5, GPX1, GPX4, ICAM1
33hyperglycemia10.0GPX5, GPX1, GPX4, VCAM1
34vernal keratoconjunctivitis10.0VCAM1, ICAM1, CD36
35cerebral malaria10.0VCAM1, ICAM1, CD36
36myeloma10.0CD36, ICAM1, VCAM1
37primary hyperoxaluria10.0CD36, VCAM1, GPX3
38connective tissue disease10.0HLA-DRB1, VCAM1, ICAM1
39graves' disease10.0HLA-DRB1, VCAM1, ICAM1
40plasmodium falciparum malaria9.9CD36, ICAM1, HLA-DRB1
41systemic lupus erythematosus9.9HLA-DRB1, VCAM1, ICAM1
42psoriasis9.9ICAM1, VCAM1, HLA-DRB1
43multiple sclerosis9.9ICAM1, VCAM1, HLA-DRB1
44atherosclerosis9.9GPX1, VCAM1, ICAM1, CD36
45congenital heart disease9.9ICAM1, VCAM1, GPX4, GPX1, GPX5
46malaria9.9HLA-DRB1, GPX1, ICAM1, CD36
47systemic scleroderma9.9CD36, ICAM1, VCAM1, HLA-DRB1
48leukemia9.9ICAM1, GPX4, GPX1, HLA-DRB1
49hypersensitivity reaction type ii disease9.9ICAM1, VCAM1, HLA-DRB1
50melanoma9.9CD36, ICAM1, VCAM1, HLA-DRB1

Graphical network of the top 20 diseases related to Keshan Disease:



Diseases related to keshan disease

Symptoms for Keshan Disease

About this section

Drugs & Therapeutics for Keshan Disease

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Keshan Disease

Search NIH Clinical Center for Keshan Disease

Genetic Tests for Keshan Disease

About this section

Anatomical Context for Keshan Disease

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Keshan Disease:

33
Heart, Liver, Pancreatic islet

Animal Models for Keshan Disease or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Keshan Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.2CD36, ICAM1, DIO1, VCAM1, GPX1, GPX3
2MP:00053787.6CD36, GPX3, GPX1, GPX4, VCAM1, DIO1

Publications for Keshan Disease

About this section
Sources:
52PubMed
See all sources

Articles related to Keshan Disease:

(show all 48)
idTitleAuthorsYear
1
Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease. (24384427)
2014
2
The prevalence of Keshan disease in China. (23218571)
2013
3
Oxidative stress is involved in the pathogenesis of Keshan disease (an endemic dilated cardiomyopathy) in China. (24062877)
2013
4
An original discovery: selenium deficiency and Keshan disease (an endemic heart disease). (22705420)
2012
5
Analysis of glutathione peroxidase 1 gene polymorphism and Keshan disease in Heilongjiang Province, China. (22180033)
2011
6
The effect of DHEA treatment on the oxidative stress and myocardial fibrosis induced by Keshan disease pathogenic factors. (21602037)
2011
7
Suboptimal selenium supply--a continuing problem in Keshan disease areas in Heilongjiang province. (21253891)
2011
8
Is selenium deficiency really the cause of Keshan disease? (20574681)
2011
9
Selenium level surveillance for the year 2007 of Keshan disease in endemic areas and analysis on surveillance results between 2003 and 2007. (20180046)
2010
10
Chronic exposure to cereal mycotoxin likely citreoviridin may be a trigger for Keshan disease mainly through oxidative stress mechanism. (20034747)
2010
11
Polymorphisms in the glutathione peroxidase-1 gene associated with increased risk of Keshan disease]. (21055077)
2010
12
Circulating adhesion molecules in patients with Keshan disease and their relationship with Coxsackie B virus infection. (19399399)
2009
13
The study on relation of HLA-DRB1 gene polymorphism to Keshan disease and its association and linkage in the core families]. (17285554)
2007
14
Keshan disease and mitochondrial cardiomyopathy. (17312989)
2006
15
Coxsackievirus B3 infection and its mutation in Keshan disease. (15484304)
2004
16
Multifocal myocardial necrosis: a distinctive cardiac lesion in cystic fibrosis, lipomatous pancreatic atrophy, and Keshan disease. (12056507)
2002
17
Fulminant heart failure due to selenium deficiency cardiomyopathy (Keshan disease). (11848134)
2002
18
Selenite inhibition of Coxsackie virus B5 replication: implications on the etiology of Keshan disease. (11878751)
2002
19
HIV-associated cardiomyopathy is not Keshan disease. (12042392)
2002
20
High prevalence of enteroviral genomic sequences in myocardium from cases of endemic cardiomyopathy (Keshan disease) in China. (10814633)
2000
21
Morphological studies of myocardial fibrosis in different types of Keshan disease]. (11244934)
1998
22
Alterations in rat pancreatic islet beta cells induced by Keshan disease pathogenic factors: protective action of selenium and vitamin E. (9550538)
1998
23
Interacting nutritional and infectious etiologies of Keshan disease. Insights from coxsackie virus B-induced myocarditis in mice deficient in selenium or vitamin E. (9152508)
1997
24
Further investigation on the role of selenium deficiency in the aetiology and pathogenesis of Keshan disease. (9315325)
1997
25
A survey of moniliformin contamination in rice and corn from Keshan disease endemic and non-KSD areas in China. (8719174)
1995
26
Antioxidant status, erythrocyte fatty acids, and mortality from cardiovascular disease and Keshan disease in China. (7956986)
1994
27
Effects of selenium and alpha-tocopherol on liver damage induced by feeding grains from an endemic area of Keshan disease in rats. (7969093)
1994
28
Damage to hepatic thyroxine 5'-deiodination induced by pathogenic factors of Keshan disease and the preventive effects of selenium and vitamin E. (1781930)
1991
29
Common denominators in the etiology and pathology of visceral lesions of cystic fibrosis and Keshan disease. (1702672)
1990
30
The effect of selenium-fortified table salt in the prevention of Keshan disease on a population of 1.05 million. (2096847)
1990
31
Increased sarcolemmal membrane permeability of cardiac muscle cells in rats fed grains cultivated in a Keshan disease endemic area: a study with horseradish peroxidase as a tracer. (2721651)
1989
32
Keshan disease: an entity or not. (3402979)
1988
33
Keshan disease--an endemic mitochondrial cardiomyopathy in China. (2908794)
1988
34
Pancreatic lesions of Keshan disease and its significances. (3129250)
1987
35
Keshan disease: an endemic cardiomyopathy in China. (3997137)
1985
36
The role of selenium in Keshan disease. (6507187)
1984
37
M-mode echocardiographic features of children with Keshan disease. A preliminary observation of 106 cases. (6242288)
1984
38
Nutritional bio-geochemical etiology of Keshan disease. (6416757)
1983
39
Keshan disease-an endemic cardiomyopathy in China. (6412443)
1983
40
Pathology of Keshan disease. A comprehensive review. (6413138)
1983
41
Keshan disease and selenium in China. (7075240)
1982
42
A study of nutritional and bio-geochemical factors in the occurrence and development of Keshan disease. (7131711)
1982
43
Studies on the relations of selenium and Keshan disease. (24272892)
1980
44
On the etiology of Keshan disease: two hypotheses. (110554)
1979
45
Epidemiologic studies on the etiologic relationship of selenium and Keshan disease. (114372)
1979
46
Observations on effect of sodium selenite in prevention of Keshan disease. (114371)
1979
47
The vetosidum in the treatment of Keshan disease. (411634)
1977
48
PATHOLOGIC CHANGES OF THE CONDUCTION SYSTEM OF THE HEART IN 43 CASES OF KESHAN DISEASE. (14191216)
1964

Variations for Keshan Disease

About this section

Expression for genes affiliated with Keshan Disease

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Keshan Disease

Search GEO for disease gene expression data for Keshan Disease.

Pathways for genes affiliated with Keshan Disease

About this section
Sources:
50PathCards, 30KEGG, 60Thomson Reuters, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome, 51PharmGKB
See all sources

Pathways related to Keshan Disease according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ICAM1, VCAM1
29.7ICAM1, VCAM1
39.7ICAM1, VCAM1
49.7ICAM1, VCAM1
5
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.7ICAM1, VCAM1
69.7GPX3, GPX1
79.6ICAM1, HLA-DRB1
89.3CD36, ICAM1, VCAM1
99.3CD36, ICAM1, VCAM1
10
Show member pathways
9.3HLA-DRB1, VCAM1, ICAM1
119.3ICAM1, VCAM1, HLA-DRB1
129.3ICAM1, VCAM1, HLA-DRB1
13
Show member pathways
9.1GPX3, GPX1, GPX8
14
Show member pathways
9.1GPX8, GPX1, GPX3
15
Show member pathways
8.9HLA-DRB1, VCAM1, ICAM1, CD36
16
Show member pathways
Vitamin B12 Metabolism38
8.5GPX4, GPX6, GPX1, GPX3
178.2GPX3, GPX1, GPX6, GPX4, DIO1
18
Show member pathways
thioredoxin pathway38
7.8GPX3, GPX1, GPX6, GPX4, DIO1, ICAM1
19
Show member pathways
7.7GPX3, GPX5, GPX1, GPX6, GPX8
20
Show member pathways
7.4GPX3, GPX5, GPX1, GPX6, GPX4, GPX8
21
Show member pathways
glutathione-mediated detoxification I38
glutathione redox reactions I38
glutathione redox reactions II38
4-hydroxy-2-nonenal detoxification38
Glutathione metabolism60
Glutathione metabolism38
7.4GPX8, GPX4, GPX6, GPX1, GPX5, GPX3

Compounds for genes affiliated with Keshan Disease

About this section
Sources:
45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience
See all sources

Compounds related to Keshan Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
112-hpete4510.2GPX4, GPX1
213-hydroperoxyoctadecadienoic acid4510.2GPX4, VCAM1
312-hydroxyeicosatetraenoic acid4510.1GPX4, GPX1
4linoleic acid hydroperoxide4510.0GPX3, GPX4
5sodium cromoglycate4510.0ICAM1, VCAM1
6selenite4510.0DIO1, GPX4, GPX1
711-deoxy-pge14510.0CD36, ICAM1
8loratadine45 24 1112.0ICAM1, VCAM1
98 methoxypsoralen4510.0ICAM1, VCAM1
10selenomethionine45 2411.0GPX3, GPX4
11sele459.9VCAM1, ICAM1
12helenalin459.8ICAM1, VCAM1
13hydroxide459.8GPX3, GPX4
14gliclazide45 51 1111.8ICAM1, VCAM1
15hcec459.7ICAM1, VCAM1
16malondialdehyde459.7GPX4, GPX1, GPX3
17budesonide45 51 1111.7VCAM1, ICAM1, CD36
18homocysteine45 2410.7VCAM1, GPX1, GPX3
19acetone459.6CD36, ICAM1
20troglitazone45 29 61 1112.6CD36, ICAM1, VCAM1
21cytochalasin d45 6110.6VCAM1, ICAM1, CD36
228-isoprostane459.6ICAM1, VCAM1, GPX3
23herbimycin a45 6110.6CD36, ICAM1, VCAM1
24hyaluronic acid45 2410.5VCAM1, ICAM1, CD36
25selenocysteine45 24 1111.5DIO1, GPX4, GPX1, GPX3
26n acetylcysteine459.5ICAM1, VCAM1, GPX4, GPX1
27manganese superoxide459.4GPX3, GPX1, GPX4, VCAM1
28vitamin-e459.4GPX3, GPX1, GPX4, VCAM1
29pge2459.3GPX4, VCAM1, ICAM1, CD36
30superoxide45 2410.3GPX3, GPX1, GPX4, VCAM1
31nadph45 2410.3VCAM1, GPX4, GPX1, GPX5
32cysteine459.2GPX1, GPX4, VCAM1, DIO1, CD36
33ascorbic acid45 2410.2GPX3, GPX4, ICAM1, CD36
34phosphatidylcholine459.2VCAM1, GPX4, GPX3
35alpha tocopherol459.0GPX3, GPX1, GPX4, VCAM1, CD36
36cholesterol45 29 24 1112.0GPX3, GPX1, GPX4, VCAM1
37h2o2458.9GPX3, GPX1, GPX4, ICAM1, CD36
38oxygen45 249.9GPX3, GPX1, GPX4, VCAM1, ICAM1
39lipid458.6VCAM1, GPX4, GPX1, GPX5, GPX3
40dexamethasone45 51 29 1111.5GPX3, VCAM1, ICAM1, CD36
4115(S)-HETE248.3GPX4, GPX3, GPX5, GPX1, GPX6
425-HETE248.3GPX3, GPX5, GPX1, GPX6, GPX4
435(S)-Hydroperoxyeicosatetraenoic acid248.3GPX3, GPX5, GPX1, GPX6, GPX4
445-hpete45 249.3GPX4, GPX6, GPX1, GPX5, GPX3
45Oxidized glutathione248.3GPX3, GPX5, GPX1, GPX6, GPX4
4615(S)-HPETE248.3GPX3, GPX5, GPX1, GPX6, GPX4
47Hydrogen peroxide248.3GPX3, GPX5, GPX1, GPX6, GPX4
48Water248.3GPX3, GPX5, GPX1, GPX6, GPX4
49selenium45 249.0GPX3, GPX5, GPX1, GPX6, GPX4, DIO1
50Glutathione24 118.8GPX3, GPX5, GPX1, GPX6, GPX4, GPX8

GO Terms for genes affiliated with Keshan Disease

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Keshan Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle membraneGO:0306669.7CD36, HLA-DRB1
2external side of plasma membraneGO:0098978.6CD36, ICAM1, VCAM1, HLA-DRB1

Biological processes related to Keshan Disease according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1lipoxygenase pathwayGO:01937210.1GPX4, GPX1
2response to nicotineGO:03509410.0GPX1, VCAM1
3response to lipid hydroperoxideGO:0069829.9GPX1, GPX3
4membrane to membrane dockingGO:0226149.9VCAM1, ICAM1
5glutathione metabolic processGO:0067499.9GPX4, GPX1
6leukocyte cell-cell adhesionGO:0071599.9ICAM1, VCAM1
7heterophilic cell-cell adhesionGO:0071579.8ICAM1, VCAM1
8agingGO:0075689.7GPX1, GPX4, VCAM1
9cellular response to glucose stimulusGO:0713339.7VCAM1, ICAM1
10cellular response to tumor necrosis factorGO:0713569.7ICAM1, VCAM1
11hydrogen peroxide catabolic processGO:0427449.6GPX4, GPX1, GPX3
12response to ionizing radiationGO:0102129.6ICAM1, VCAM1
13arachidonic acid metabolic processGO:0193699.6GPX4, GPX1
14interferon-gamma-mediated signaling pathwayGO:0603339.5ICAM1, VCAM1, HLA-DRB1
15cytokine-mediated signaling pathwayGO:0192219.4ICAM1, VCAM1, HLA-DRB1
16response to oxidative stressGO:0069798.8GPX8, GPX6, GPX5

Molecular functions related to Keshan Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione bindingGO:0432959.9GPX4, GPX1
2phospholipid-hydroperoxide glutathione peroxidase activityGO:0470669.6GPX4, GPX1
3selenium bindingGO:0084308.9GPX3, GPX1, GPX4, DIO1
4glutathione peroxidase activityGO:0046027.4GPX8, GPX4, GPX6, GPX1, GPX5, GPX3

Products for genes affiliated with Keshan Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Keshan Disease

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet