MCID: KSH001
MIFTS: 39

Keshan Disease malady

Summaries for Keshan Disease

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium... more...

MalaCards: Keshan Disease, also known as caused by deficiency of selenium in the diet, is related to pancreatitis and cystic fibrosis. An important gene associated with Keshan Disease is GPX1 (glutathione peroxidase 1), and among its related pathways are Synthesis of 15-eicosatetraenoic acid derivatives and LDL Oxidation in Atherogenesis. The compounds 12-hpete and 13-hydroperoxyoctadecadienoic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and pancreatic islet, and related mouse phenotypes are hematopoietic system and cardiovascular system.

Aliases & Classifications for Keshan Disease

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS
See all sources

Aliases & Descriptions:

keshan disease 8 42 10 60
caused by deficiency of selenium in the diet 42
enlarged heart and poor heart function 42


External Ids:

Disease Ontology8 DOID:0050083

Related Diseases for Keshan Disease

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Keshan Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis30.4ICAM1
2cystic fibrosis10.2
3hepatitis e10.1
4dilated cardiomyopathy10.1
5heart conduction disease10.1
6hepatitis10.1
7liver disease10.1
8myocarditis10.1
9nutritional deficiency disease10.1
10adenocarcinoma10.0PTGER2
11acute myocardial infarction10.0GPX3
12colorectal cancer10.0GPX3
13pneumonia10.0ICAM1
14dementia10.0GPX3
15thyroiditis10.0HLA-DRB1
16liver cirrhosis10.0HLA-DRB1
17hypercholesterolemia10.0VCAM1
18ischemia10.0GPX1, ICAM1
19adenoma10.0GPX3, PTGER2
20sickle cell disease10.0VCAM1
21cataract10.0GPX3, GPX1
22coronary heart disease10.0VCAM1
23vascular disease10.0GPX1, GPX5, GPX4
24alzheimer's disease10.0HLA-DRB1
25cork-handlers' disease10.0GPX5, GPX1, GPX4
26prion disease10.0GPX5, GPX1, GPX4
27nephritis10.0VCAM1
28pancreatic cancer10.0CD36
29toxic encephalopathy10.0GPX4, GPX5, GPX1
30cerebral malaria10.0CD36, ICAM1
31hepatitis b10.0GPX1, HLA-DRB1
32viral hepatitis10.0HLA-DRB1
33arthritis10.0HLA-DRB1, ICAM1
34acute chest syndrome10.0VCAM1
35rheumatoid vasculitis10.0ICAM1, VCAM1
36hypertension10.0ICAM1, VCAM1
37osteoarthritis10.0CD36, VCAM1
38galactosemia10.0GPX1, GPX4, ICAM1, GPX5
39glomerulonephritis10.0ICAM1, VCAM1
40myositis10.0ICAM1, VCAM1
41vasculitis10.0ICAM1, VCAM1
42breast cancer10.0GPX4, GPX1, PTGER2, GPX3
43immunoglobulin a vasculitis10.0ICAM1, VCAM1
44inclusion body myositis10.0ICAM1, VCAM1
45leukostasis10.0ICAM1, VCAM1
46primary hyperoxaluria10.0ICAM1, VCAM1
47proliferative diabetic retinopathy10.0VCAM1, ICAM1
48oral lichen planus10.0ICAM1, VCAM1
49polymyositis10.0ICAM1, VCAM1
50hyperglycemia10.0GPX1, GPX5, GPX4, VCAM1

Graphical network of the top 20 diseases related to Keshan Disease:



Diseases related to keshan disease

Clinical Features for Keshan Disease

About this section

Drugs & Therapeutics for Keshan Disease

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Keshan Disease

Drug clinical trials:

Search ClinicalTrials for Keshan Disease

Search NIH Clinical Center for Keshan Disease

Search CenterWatch for Keshan Disease

Genetic Tests for Keshan Disease

About this section

Anatomical Context for Keshan Disease

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Keshan Disease:

32
Heart, Liver, Pancreatic islet

Animal Models for Keshan Disease or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Keshan Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.1CD36, GPX7, GPX1, GPX3, PTGER2, VCAM1
2MP:00053857.4VCAM1, ICAM1, EMILIN1, CD36, GPX7, GPX3

Publications for Keshan Disease

About this section
Sources:
50PubMed
See all sources

Articles related to Keshan Disease:

(show all 49)
idTitleAuthorsYear
1
Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease. (24384427)
2014
2
The prevalence of Keshan disease in China. (23218571)
2013
3
Oxidative stress is involved in the pathogenesis of Keshan disease (an endemic dilated cardiomyopathy) in China. (24062877)
2013
4
An original discovery: selenium deficiency and Keshan disease (an endemic heart disease). (22705420)
2012
5
Analysis of glutathione peroxidase 1 gene polymorphism and Keshan disease in Heilongjiang Province, China. (22180033)
2011
6
The effect of DHEA treatment on the oxidative stress and myocardial fibrosis induced by Keshan disease pathogenic factors. (21602037)
2011
7
Suboptimal selenium supply--a continuing problem in Keshan disease areas in Heilongjiang province. (21253891)
2011
8
Is selenium deficiency really the cause of Keshan disease? (20574681)
2011
9
Selenium level surveillance for the year 2007 of Keshan disease in endemic areas and analysis on surveillance results between 2003 and 2007. (20180046)
2010
10
Chronic exposure to cereal mycotoxin likely citreoviridin may be a trigger for Keshan disease mainly through oxidative stress mechanism. (20034747)
2010
11
Polymorphisms in the glutathione peroxidase-1 gene associated with increased risk of Keshan disease]. (21055077)
2010
12
Circulating adhesion molecules in patients with Keshan disease and their relationship with Coxsackie B virus infection. (19399399)
2009
13
The study on relation of HLA-DRB1 gene polymorphism to Keshan disease and its association and linkage in the core families]. (17285554)
2007
14
Keshan disease and mitochondrial cardiomyopathy. (17312989)
2006
15
Coxsackievirus B3 infection and its mutation in Keshan disease. (15484304)
2004
16
Multifocal myocardial necrosis: a distinctive cardiac lesion in cystic fibrosis, lipomatous pancreatic atrophy, and Keshan disease. (12056507)
2002
17
Fulminant heart failure due to selenium deficiency cardiomyopathy (Keshan disease). (11848134)
2002
18
Selenite inhibition of Coxsackie virus B5 replication: implications on the etiology of Keshan disease. (11878751)
2002
19
HIV-associated cardiomyopathy is not Keshan disease. (12042392)
2002
20
High prevalence of enteroviral genomic sequences in myocardium from cases of endemic cardiomyopathy (Keshan disease) in China. (10814633)
2000
21
Morphological studies of myocardial fibrosis in different types of Keshan disease]. (11244934)
1998
22
Alterations in rat pancreatic islet beta cells induced by Keshan disease pathogenic factors: protective action of selenium and vitamin E. (9550538)
1998
23
Interacting nutritional and infectious etiologies of Keshan disease. Insights from coxsackie virus B-induced myocarditis in mice deficient in selenium or vitamin E. (9152508)
1997
24
Further investigation on the role of selenium deficiency in the aetiology and pathogenesis of Keshan disease. (9315325)
1997
25
A survey of moniliformin contamination in rice and corn from Keshan disease endemic and non-KSD areas in China. (8719174)
1995
26
Antioxidant status, erythrocyte fatty acids, and mortality from cardiovascular disease and Keshan disease in China. (7956986)
1994
27
Effects of selenium and alpha-tocopherol on liver damage induced by feeding grains from an endemic area of Keshan disease in rats. (7969093)
1994
28
Damage to hepatic thyroxine 5'-deiodination induced by pathogenic factors of Keshan disease and the preventive effects of selenium and vitamin E. (1781930)
1991
29
Common denominators in the etiology and pathology of visceral lesions of cystic fibrosis and Keshan disease. (1702672)
1990
30
The effect of selenium-fortified table salt in the prevention of Keshan disease on a population of 1.05 million. (2096847)
1990
31
Increased sarcolemmal membrane permeability of cardiac muscle cells in rats fed grains cultivated in a Keshan disease endemic area: a study with horseradish peroxidase as a tracer. (2721651)
1989
32
Keshan disease: an entity or not. (3402979)
1988
33
Keshan disease--an endemic mitochondrial cardiomyopathy in China. (2908794)
1988
34
Pancreatic lesions of Keshan disease and its significances. (3129250)
1987
35
Selenium and cardiomyopathy (Keshan disease). (3776583)
1986
36
Keshan disease: an endemic cardiomyopathy in China. (3997137)
1985
37
The role of selenium in Keshan disease. (6507187)
1984
38
M-mode echocardiographic features of children with Keshan disease. A preliminary observation of 106 cases. (6242288)
1984
39
Nutritional bio-geochemical etiology of Keshan disease. (6416757)
1983
40
Keshan disease-an endemic cardiomyopathy in China. (6412443)
1983
41
Pathology of Keshan disease. A comprehensive review. (6413138)
1983
42
Keshan disease and selenium in China. (7075240)
1982
43
A study of nutritional and bio-geochemical factors in the occurrence and development of Keshan disease. (7131711)
1982
44
Studies on the relations of selenium and Keshan disease. (24272892)
1980
45
On the etiology of Keshan disease: two hypotheses. (110554)
1979
46
Epidemiologic studies on the etiologic relationship of selenium and Keshan disease. (114372)
1979
47
Observations on effect of sodium selenite in prevention of Keshan disease. (114371)
1979
48
The vetosidum in the treatment of Keshan disease. (411634)
1977
49
PATHOLOGIC CHANGES OF THE CONDUCTION SYSTEM OF THE HEART IN 43 CASES OF KESHAN DISEASE. (14191216)
1964

Genetic Variations for Keshan Disease

About this section

Expression for genes affiliated with Keshan Disease

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Keshan Disease

Search GEO for disease gene expression data for Keshan Disease.

Pathways for genes affiliated with Keshan Disease

About this section
Sources:
53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore
See all sources

Compounds for genes affiliated with Keshan Disease

About this section
Sources:
44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 49PharmGKB, 59Tocris Bioscience
See all sources

Compounds related to Keshan Disease according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
112-hpete4410.4GPX4, GPX1
213-hydroperoxyoctadecadienoic acid4410.3VCAM1, GPX4
312-hydroxyeicosatetraenoic acid4410.3GPX4, GPX1
4sulprostone44 2811.2PTGER2, ICAM1
5sodium cromoglycate4410.2VCAM1, ICAM1
6selenite4410.1DIO1, GPX1, GPX4
7oxygen44 2411.1ICAM1
8loratadine44 11 2412.1ICAM1, VCAM1
98 methoxypsoralen4410.1ICAM1, VCAM1
10linoleic acid hydroperoxide4410.1GPX4, GPX3
11sele4410.1VCAM1, ICAM1
12selenomethionine44 2411.0GPX3, GPX4
1311-deoxy-pge14410.0PTGER2, CD36, ICAM1
14helenalin4410.0ICAM1, VCAM1
15hydroxide4410.0GPX4, GPX3
16budesonide44 49 1111.9VCAM1, CD36, ICAM1
17gliclazide44 49 1111.9VCAM1, ICAM1
18hcec449.9VCAM1, ICAM1
19malondialdehyde449.9GPX1, GPX4, GPX3
20superoxide44 2410.8VCAM1, GPX4
21nadph44 2410.8GPX4, GPX5, GPX1
22selenophosphate44 2410.8SEPW1, GPX4
23troglitazone44 28 59 1112.7VCAM1, CD36, ICAM1
24n acetylcysteine449.7ICAM1, GPX1, GPX4, VCAM1
25homocysteine44 2410.7VCAM1, GPX3, GPX1
268-isoprostane449.7VCAM1, GPX3, ICAM1
27cytochalasin d44 5910.7VCAM1, CD36, ICAM1
28manganese superoxide449.6GPX1, GPX4, GPX3, VCAM1
29vitamin-e449.6VCAM1, GPX3, GPX4, GPX1
30herbimycin a44 5910.5ICAM1, CD36, VCAM1
31arachidonic acid44 28 11 2412.5PTGER2, GPX3, GPX4, GPX1
32ascorbic acid44 2410.5GPX3, GPX4, CD36, ICAM1
33alpha tocopherol449.3CD36, GPX1, GPX4, GPX3, VCAM1
34hyaluronic acid44 2410.2VCAM1, CD36, ICAM1
35h2o2449.2ICAM1, CD36, GPX1, GPX4, GPX3
36dexamethasone44 49 28 1112.1ICAM1, CD36, GPX3, PTGER2, VCAM1
37nitric oxide44 11 2411.1ICAM1, GPX1, GPX3, PTGER2, VCAM1
38selenocysteine44 11 2410.8DIO1, GPX1, GPX4, GPX3, SEPW1
39cysteine448.7DIO1, CD36, GPX1, GPX4, VCAM1, SEPW1
405-hpete44 249.5GPX7, GPX1, GPX6, GPX5, GPX4, GPX3
41Glutathione11 249.1GPX8, GPX7, GPX1, GPX6, GPX5, GPX4
42selenium44 248.4SEPW1, DIO1, GPX7, GPX1, GPX6, GPX5

GO Terms for genes affiliated with Keshan Disease

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Keshan Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2VCAM1, CD36, HLA-DRB1, ICAM1

Biological processes related to Keshan Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoxygenase pathwayGO:0193729.9GPX4, GPX1
2membrane to membrane dockingGO:0226149.9VCAM1, ICAM1
3interferon-gamma-mediated signaling pathwayGO:0603339.5ICAM1, HLA-DRB1, VCAM1
4hydrogen peroxide catabolic processGO:0427449.4GPX3, GPX1
5cell adhesionGO:0071558.9VCAM1, CD36, EMILIN1, ICAM1
6response to oxidative stressGO:0069798.6GPX4, GPX5, GPX6, GPX7, GPX8

Molecular functions related to Keshan Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1selenium bindingGO:0084308.9SEPW1, GPX3, DIO1
2glutathione peroxidase activityGO:0046027.4GPX3, GPX8, GPX7, GPX1, GPX6, GPX5

Products for genes affiliated with Keshan Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Keshan Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet