MCID: KSH001
MIFTS: 26

Keshan Disease malady

Rare diseases, Metabolic diseases categories

Aliases & Classifications for Keshan Disease

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Aliases & Descriptions for Keshan Disease:

Name: Keshan Disease 10 45 12 65
Caused by Deficiency of Selenium in the Diet 45
 
Enlarged Heart and Poor Heart Function 45


Classifications:



External Ids:

Disease Ontology10 DOID:0050083

Summaries for Keshan Disease

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Wikipedia:68 Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium... more...

MalaCards based summary: Keshan Disease, also known as caused by deficiency of selenium in the diet, is related to cardiomyopathy and pancreatitis. An important gene associated with Keshan Disease is GPX1 (Glutathione Peroxidase 1), and among its related pathways are MHC class II antigen presentation and CTLA4 Signaling. Affiliated tissues include heart, pancreatic islet and liver, and related mouse phenotype immune system.

Related Diseases for Keshan Disease

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Diseases related to Keshan Disease via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1cardiomyopathy10.6
2pancreatitis10.4
3cystic fibrosis10.3
4mitochondrial cardiomyopathy10.3
5dilated cardiomyopathy10.1
6hepatitis10.1
7myocarditis10.1
8fallopian tube endometrioid adenocarcinoma8.9BMP5, BMP7, GPX1, HLA-DOA, HLA-DRA, SCN5A

Graphical network of diseases related to Keshan Disease:



Diseases related to keshan disease

Symptoms for Keshan Disease

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Drugs & Therapeutics for Keshan Disease

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Drugs for Keshan Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Sodium SelenitePhase 316
2
SeleniumPhase 31617782-49-2
Synonyms:
Selanediide
Selenide
 
Selenide(2-)
Selenium
Selenium ion (Se2+)

Interventional clinical trials:

idNameStatusNCT IDPhase
1Selenium Treatment and Chagasic Cardiopathy (STCC)RecruitingNCT00875173Phase 3

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Genetic Tests for Keshan Disease

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Anatomical Context for Keshan Disease

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MalaCards organs/tissues related to Keshan Disease:

33
Heart, Pancreatic islet, Liver

Animal Models for Keshan Disease or affiliated genes

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MGI Mouse Phenotypes related to Keshan Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1BMP5, BMP7, GPX1, HLA-DOA, TNFSF15

Publications for Keshan Disease

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Articles related to Keshan Disease:

(show top 50)    (show all 54)
idTitleAuthorsYear
1
Keshan disease, selenium deficiency, and the selenoproteome. (24785212)
2014
2
H558R polymorphism in SCN5A is associated with Keshan disease and QRS prolongation in Keshan disease patients. (25177937)
2014
3
Serum biomarkers of Keshan disease assessed using a protein profiling approach based on ClinProt technique. (24841853)
2014
4
Long-term prognostic value of major and minor ECG abnormalities in latent Keshan disease with suspect chronic Keshan disease. (24975014)
2014
5
TLR2-ICAM1-Gadd45I+ axis mediates the epigenetic effect of selenium on DNA methylation and gene expression in Keshan disease. (24811888)
2014
6
The prevalence of Keshan disease in China. (23218571)
2013
7
Oxidative stress is involved in the pathogenesis of Keshan disease (an endemic dilated cardiomyopathy) in China. (24062877)
2013
8
An original discovery: selenium deficiency and Keshan disease (an endemic heart disease). (22705420)
2012
9
Analysis of glutathione peroxidase 1 gene polymorphism and Keshan disease in Heilongjiang Province, China. (22180033)
2011
10
The effect of DHEA treatment on the oxidative stress and myocardial fibrosis induced by Keshan disease pathogenic factors. (21602037)
2011
11
Suboptimal selenium supply--a continuing problem in Keshan disease areas in Heilongjiang province. (21253891)
2011
12
Is selenium deficiency really the cause of Keshan disease? (20574681)
2011
13
Selenium level surveillance for the year 2007 of Keshan disease in endemic areas and analysis on surveillance results between 2003 and 2007. (20180046)
2010
14
Chronic exposure to cereal mycotoxin likely citreoviridin may be a trigger for Keshan disease mainly through oxidative stress mechanism. (20034747)
2010
15
Polymorphisms in the glutathione peroxidase-1 gene associated with increased risk of Keshan disease]. (21055077)
2010
16
Circulating adhesion molecules in patients with Keshan disease and their relationship with Coxsackie B virus infection. (19399399)
2009
17
The study on relation of HLA-DRB1 gene polymorphism to Keshan disease and its association and linkage in the core families]. (17285554)
2007
18
Keshan disease and mitochondrial cardiomyopathy. (17312989)
2006
19
Coxsackievirus B3 infection and its mutation in Keshan disease. (15484304)
2004
20
Multifocal myocardial necrosis: a distinctive cardiac lesion in cystic fibrosis, lipomatous pancreatic atrophy, and Keshan disease. (12056507)
2002
21
Fulminant heart failure due to selenium deficiency cardiomyopathy (Keshan disease). (11848134)
2002
22
Selenite inhibition of Coxsackie virus B5 replication: implications on the etiology of Keshan disease. (11878751)
2002
23
HIV-associated cardiomyopathy is not Keshan disease. (12042392)
2002
24
High prevalence of enteroviral genomic sequences in myocardium from cases of endemic cardiomyopathy (Keshan disease) in China. (10814633)
2000
25
Morphological studies of myocardial fibrosis in different types of Keshan disease]. (11244934)
1998
26
Alterations in rat pancreatic islet beta cells induced by Keshan disease pathogenic factors: protective action of selenium and vitamin E. (9550538)
1998
27
Interacting nutritional and infectious etiologies of Keshan disease. Insights from coxsackie virus B-induced myocarditis in mice deficient in selenium or vitamin E. (9152508)
1997
28
Further investigation on the role of selenium deficiency in the aetiology and pathogenesis of Keshan disease. (9315325)
1997
29
A survey of moniliformin contamination in rice and corn from Keshan disease endemic and non-KSD areas in China. (8719174)
1995
30
Antioxidant status, erythrocyte fatty acids, and mortality from cardiovascular disease and Keshan disease in China. (7956986)
1994
31
Damage to hepatic thyroxine 5'-deiodination induced by pathogenic factors of Keshan disease and the preventive effects of selenium and vitamin E. (1781930)
1991
32
Common denominators in the etiology and pathology of visceral lesions of cystic fibrosis and Keshan disease. (1702672)
1990
33
The effect of selenium-fortified table salt in the prevention of Keshan disease on a population of 1.05 million. (2096847)
1990
34
Increased sarcolemmal membrane permeability of cardiac muscle cells in rats fed grains cultivated in a Keshan disease endemic area: a study with horseradish peroxidase as a tracer. (2721651)
1989
35
Keshan disease: an entity or not. (3402979)
1988
36
Keshan disease--an endemic mitochondrial cardiomyopathy in China. (2908794)
1988
37
Pancreatic lesions of Keshan disease and its significances. (3129250)
1987
38
Selenium and cardiomyopathy (Keshan disease). (3776583)
1986
39
Keshan disease: an endemic cardiomyopathy in China. (3997137)
1985
40
The role of selenium in Keshan disease. (6507187)
1984
41
Nutritional bio-geochemical etiology of Keshan disease. (6416757)
1983
42
Keshan disease-an endemic cardiomyopathy in China. (6412443)
1983
43
Keshan disease and selenium in China. (7075240)
1982
44
A study of nutritional and bio-geochemical factors in the occurrence and development of Keshan disease. (7131711)
1982
45
Studies on the relations of selenium and Keshan disease. (24272892)
1980
46
On the etiology of Keshan disease: two hypotheses. (110554)
1979
47
Epidemiologic studies on the etiologic relationship of selenium and Keshan disease. (114372)
1979
48
Observations on effect of sodium selenite in prevention of Keshan disease. (114371)
1979
49
The vetosidum in the treatment of Keshan disease. (411634)
1977
50
PATHOLOGIC CHANGES OF THE CONDUCTION SYSTEM OF THE HEART IN 43 CASES OF KESHAN DISEASE. (14191216)
1964

Variations for Keshan Disease

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Expression for genes affiliated with Keshan Disease

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Search GEO for disease gene expression data for Keshan Disease.

Pathways for genes affiliated with Keshan Disease

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Pathways related to Keshan Disease according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5HLA-DOA, HLA-DRA
29.5HLA-DOA, HLA-DRA
39.5HLA-DOA, HLA-DRA
49.5HLA-DOA, HLA-DRA
5
TGF-beta Signaling Pathway (sino)
Show member pathways
9.5HLA-DOA, HLA-DRA
6
TGF-beta signaling pathway (KEGG)
Show member pathways
9.5HLA-DOA, HLA-DRA
79.5BMP5, BMP7

GO Terms for genes affiliated with Keshan Disease

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Cellular components related to Keshan Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membrane-bounded vesicleGO:00319889.5BMP5, BMP7
2MHC class II protein complexGO:00426139.2HLA-DOA, HLA-DRA

Biological processes related to Keshan Disease according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.2BMP5, GPX1
2growthGO:004000710.0BMP5, BMP7
3positive regulation of pathway-restricted SMAD protein phosphorylationGO:001086210.0BMP5, BMP7
4antigen processing and presentationGO:001988210.0HLA-DOA, HLA-DRA
5pattern specification processGO:000738910.0BMP5, BMP7
6SMAD protein signal transductionGO:00603959.9BMP5, BMP7
7positive regulation of dendrite developmentGO:19000069.9BMP5, BMP7
8antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.8HLA-DOA, HLA-DRA
9positive regulation of epithelial cell proliferationGO:00506799.7BMP5, SCN5A
10BMP signaling pathwayGO:00305099.6BMP5, BMP7
11cartilage developmentGO:00512169.5BMP5, BMP7
12response to estradiolGO:00323559.5BMP7, GPX1
13odontogenesis of dentin-containing toothGO:00424759.3BMP7, SCN5A
14ossificationGO:00015039.2BMP5, BMP7
15immune responseGO:00069559.1HLA-DOA, HLA-DRA, TNFSF15

Molecular functions related to Keshan Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:003239510.0HLA-DOA, HLA-DRA
2transforming growth factor beta receptor bindingGO:00051609.8BMP5, BMP7
3BMP receptor bindingGO:00707009.8BMP5, BMP7
4MHC class II protein complex bindingGO:00230269.7HLA-DOA, HLA-DRA
5cytokine activityGO:00051258.9BMP5, BMP7, TNFSF15

Sources for Keshan Disease

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet