MCID: KDN017
MIFTS: 56

Kidney Cancer malady

Summaries for Kidney Cancer

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 You have two kidneys. they are fist-sized organs on either side of your backbone above your waist. the tubes inside filter and clean your blood, taking out waste products and making urine. kidney cancer forms in the lining of tiny tubes inside your kidneys. kidney cancer becomes more likely as you age. risk factors include smoking, having certain genetic conditions, and misusing pain medicines for a long time. you may have no symptoms at first. they may appear as the cancer grows. see your health care provider if you notice blood in your urine a lump in your abdomen weight loss for no reason pain in your side that does not go away loss of appetite treatment depends on your age, your overall health and how advanced the cancer is. it might include surgery, chemotherapy, or radiation, biologic, or targeted therapies. biologic therapy boosts your body's own ability to fight cancer. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Kidney Cancer, also known as renal cell carcinoma, is related to adenocarcinoma and kidney rhabdoid cancer. An important gene associated with Kidney Cancer is RNF139 (ring finger protein 139). The drugs medroxyprogesterone and medroxyprogesterone acetate and the compounds fumarate and sunitinib have been mentioned in the context of this disorder. Affiliated tissues include the kidney, and related mouse phenotype liver/biliary system.

Disease Ontology:8 A urinary system cancer that is located in the kidney.

Wikipedia:64 Kidney cancer is a type of cancer that starts in the cells in the kidney. more...

Description from OMIM:47 144700

Aliases & Classifications for Kidney Cancer

Sources:
61UMLS, 8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 34MedlinePlus, 45Novoseek, 47OMIM, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Aliases & Descriptions:

kidney cancer 8 43 10 34
renal cell carcinoma 47 10 61
renal cancer 8 43 45
renal cell carcinoma 1 43 61
malignant neoplasm of kidney except pelvis 8
conventional renal cell carcinoma 61
malignant neoplasm of kidney 61
malignant tumour of kidney 8
renal adenocarcinoma 43
carcinoma renal cell 45
renal cell cancer 43
hypernephroma 43


External Ids:

Disease Ontology8 DOID:263
NCIt40 C3150
MeSH35 D007680

Related Diseases for Kidney Cancer

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Kidney Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 334)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.7VHL, HNF1B
2kidney rhabdoid cancer30.2PLIN2, FLCN, FH, IFNA1, VHL, IL2
3fumarate hydratase deficiency30.0FH
4colorectal cancer29.8HNF1A, GSTM3, IFNA1, FABP1, IL2
5adenoma29.8VHL, FABP1, HNF1A
6multilocular cystic renal cell carcinoma10.8
7angiomyolipoma10.8
8bone carcinoma10.8
9small cell carcinoma10.7
10parathyroid carcinoma10.6
11adrenal carcinoma10.6
12nonpapillary renal cell carcinoma10.6
13large cell carcinoma10.6
14renal cell carcinoma, somatic10.6
15chromophil renal cell carcinoma10.6
16papillary adenoma10.5
17xanthogranulomatous pyelonephritis10.5
18multilocular clear cell renal cell carcinoma10.5
19hypercalcemia10.5
20adrenocortical carcinoma10.5
21renal cell carcinoma, papillary, 110.5
22renal wilms' tumor10.5
23spindle cell carcinoma10.4
24metanephric adenoma10.4
25hereditary conventional renal cell carcinoma10.4
26polycystic kidney disease10.4
27autosomal dominant disease10.4
28squamous cell carcinoma10.4
29polycystic kidney disease, autosomal dominant10.4
30cystic nephroma10.3
31gastrointestinal stromal tumor10.3
32alveolar soft part sarcoma10.3
33granular cell carcinoma10.3
34pheochromocytoma10.3
35retroperitoneal fibrosis10.3
36renal cell carcinoma 410.3
37paraneoplastic syndromes10.3
38crescentic glomerulonephritis10.2
39cystadenoma10.2
40erythema multiforme10.2
41microphthalmia10.2
42autoimmune hemolytic anemia10.2
43renal tuberculosis10.2
44phaeochromocytoma10.2
45paraganglioma10.2
46acute leukemia10.2
47t-cell leukemia10.2
48thrombocytopenia10.2
49thyroiditis10.2
50tuberculosis10.2

Graphical network of the top 20 diseases related to Kidney Cancer:



Diseases related to kidney cancer

Clinical Features for Kidney Cancer

Sources:
47OMIM
See all sources

Clinical features from OMIM:

144700

Drugs & Therapeutics for Kidney Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Kidney Cancer

Anatomical Context for Kidney Cancer

Sources:
14FMA
See all sources

FMA organs/tissues related to Kidney Cancer:

14
The kidney

Animal Models for Kidney Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Kidney Cancer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537010.5PLIN2, IL2, FABP1, VHL, HNF1B, HNF1A

Publications for Kidney Cancer

Sources:
51PubMed
See all sources

Articles related to Kidney Cancer:

(show top 50)    (show all 605)
idTitleAuthorsYear
1
Kidney disease and death from cancer. (24360223)
2014
2
Kidney cancer: Vascular wall margins have little impact on cancer outcomes. (24189931)
2013
3
Aerobic glycolysis: a novel target in kidney cancer. (23773105)
2013
4
The entire miR-200 seed family is strongly deregulated in clear cell renal cell cancer compared to the proximal tubular epithelial cells of the kidney. (23074016)
2013
5
Composite three-marker assay for early detection of kidney cancer. (23479363)
2013
6
SQSTM1 Is a Pathogenic Target of 5q Copy Number Gains in Kidney Cancer. (24332042)
2013
7
The relationship of postoperative complications with in-hospital outcomes and costs after renal surgery for kidney cancer. (22564425)
2013
8
Patient and caregiver knowledge and utilization of partial versus radical nephrectomy: results of a national kidney foundation survey to assess educational needs of kidney cancer patients and caregivers. (23523238)
2013
9
Targeted therapies: treating advanced kidney cancer-miles to go before we sleep. (24129349)
2013
10
Reply to Hiten D. Patel and Mohamad E. Allaf's letter to the editor re: Maxine Sun, Andreas Becker, Zhe Tian, et al. Management of localized kidney cancer: calculating cancer-specific mortality and competing risks of death for surgery and nonsurgical management. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2013.03.034. (23910940)
2013
11
Re: Thermal ablation vs surgery for localized kidney cancer: a surveillance, epidemiology, and end results (seer) database analysis. (22153419)
2012
12
Re: Kidney size and cancer-specific survival for patients undergoing nephrectomy for pT1 clear cell renal cell carcinoma. (23059210)
2012
13
Sirolimus and non-melanoma skin cancer prevention after kidney transplantation: a meta-analysis. (23167339)
2012
14
Resistance against tumour necrosis factor I+ apoptosis by the cellular prion protein is cell-specific for oral, colon and kidney cancer cell lines. (21980981)
2012
15
Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer. (23083876)
2012
16
Kidney cancer: New cell-based immunotherapy? (22349657)
2012
17
Genetic basis of kidney cancer: role of genomics for the development of disease-based therapeutics. (23038766)
2012
18
Urological cancer: TKIs strike back: complete remission in kidney cancer. (22271087)
2012
19
Kidney cancer: Incorporating new parameters into pathological staging of RCC. (21743445)
2011
20
Prognostic model for survival in patients with metastatic renal cell carcinoma: results from the international kidney cancer working group. (21828239)
2011
21
Entropy increases in kidney cancer treatment, but a bit of simplicity may emerge from chaos. (21820238)
2011
22
Progress and contrasts of the development of tivozanib for therapy of kidney cancer. (22098229)
2011
23
Insulin-like growth factors and risk of kidney cancer in men. (20517306)
2010
24
Obesity is associated with improved survival in patients with organ-confined clear-cell kidney cancer. (20652393)
2010
25
Identification of a microRNA panel for clear-cell kidney cancer. (20035975)
2010
26
Predictive value of baseline serum vascular endothelial growth factor and neutrophil gelatinase-associated lipocalin in advanced kidney cancer patients receiving sunitinib. (20147887)
2010
27
Occupational trichloroethylene exposure and kidney cancer: a meta-analysis. (20010212)
2010
28
Screening for kidney cancer: is there a role for aquaporin-1 and adipophilin? (20435833)
2010
29
Changes in dendritic cell phenotype after a new high-dose weekly schedule of interleukin-2 therapy for kidney cancer and melanoma. (20842055)
2010
30
What's new in 2008 in kidney cancer?]. (19447330)
2009
31
Kidney cancer: The prognostic value of urinary collecting system invasion. (19956192)
2009
32
Focal therapy for kidney cancer: a systematic review. (19188769)
2009
33
Quantitative assessment of red meat or processed meat consumption and kidney cancer. (19303221)
2009
34
Bilateral leiomyosarcoma of the kidney with family history of kidney cancer. (19796464)
2009
35
Antisense attenuation of p21 sensitizes kidney cancer to apoptosis in response to conventional DNA damaging chemotherapy associated with enhancement of phospho-p53. (18499163)
2008
36
Robotic nephrectomy for kidney cancer in a horseshoe kidney with renal vein tumor thrombus: novel technique for thrombectomy. (18721039)
2008
37
The changing pattern of kidney cancer incidence and mortality in Europe. (18241251)
2008
38
Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells. (18292810)
2008
39
Sorafenib [corrected] in kidney cancer. (17631603)
2007
40
Integrated therapy of kidney cancer. (17591809)
2007
41
Activity of continuous infusion plus pulse interleukin-2 with famotidine in patients with metastatic kidney cancer or melanoma previously treated with interleukin-2. (17105418)
2006
42
Radiofrequency ablation in the treatment of kidney cancer. (16544444)
2006
43
Risk of renal insufficiency in African-Americans after radical nephrectomy for kidney cancer. (16962487)
2006
44
The effect of hypertension on the risk for kidney cancer in Korean men. (15673312)
2005
45
Continuous infusion interleukin-2 and antihistamines in metastatic kidney cancer. (16248764)
2005
46
Focus on kidney cancer. (15380513)
2004
47
Practice and progress in kidney cancer: methodology for novel drug development. (15126769)
2004
48
Monoclonal antibody therapy of kidney cancer. (14650834)
2003
49
Racial disparity in incidence patterns and outcome of kidney cancer. (14665346)
2003
50
Adoptive immunotherapy and metastasized cancer of the kidney. Regulator effects of interleukin-4 on tumor infiltrating lymphocytes (TIL)]. (1843670)
1991

Genetic Variations for Kidney Cancer

Expression for genes affiliated with Kidney Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Kidney Cancer

Search GEO for disease gene expression data for Kidney Cancer.

Pathways for genes affiliated with Kidney Cancer

Compounds for genes affiliated with Kidney Cancer

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR, 24HMDB
See all sources

Compounds related to Kidney Cancer according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1fumarate45 1111.8IL2, FH, VHL
2sunitinib45 50 1112.7VHL, IFNA1, IL2
3nnmt4510.7HNF1B, HNF1A
4fatty acid4510.7S100A7, FH, FABP1, PLIN2, HNF1A
5sorafenib45 50 1112.7VHL, IFNA1, IL2
6intron a4510.7IFNA1, IL2
7mizoribine4510.7IL2, IFNA1
8denileukin diftitox45 50 1112.6IL2, IFNA1
9phosphoenolpyruvate45 1111.6HNF1A, FH, FABP1
10pentostatin45 60 29 1113.5IFNA1, IL2
11glatiramer acetate45 1111.5IFNA1, IL2
12retinoic acid45 2411.5S100A7, NDUFA13, IFNA1, HNF1A, FABP1, HNF1B
13glucose4510.4FABP1, HNF1B, HNF1A
14rapamycin4510.2FLCN, IFNA1, IL2, VHL

GO Terms for genes affiliated with Kidney Cancer

Sources:
16Gene Ontology
See all sources

Biological processes related to Kidney Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of pronephros sizeGO:03556510.5HNF1B, HNF1A
2negative regulation of cell growthGO:03030810.5GDF9, FLCN, NDUFA13
3positive regulation of transcription initiation from RNA polymerase II promoterGO:06026110.4HNF1B, HNF1A
4regulation of Wnt receptor signaling pathwayGO:03011110.2HNF1B, HNF1A

Products for genes affiliated with Kidney Cancer

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  • Lysates
  • Antibodies

Sources for Kidney Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet