MCID: KDN017
MIFTS: 66

Kidney Cancer malady

Nephrological diseases, Cancer diseases categories

Summaries for Kidney Cancer

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 You have two kidneys. they are fist-sized organs on either side of your backbone above your waist. the tubes inside filter and clean your blood, taking out waste products and making urine. kidney cancer forms in the lining of tiny tubes inside your kidneys. kidney cancer becomes more likely as you age. risk factors include smoking, having certain genetic conditions, and misusing pain medicines for a long time. you may have no symptoms at first. they may appear as the cancer grows. see your health care provider if you notice blood in your urine a lump in your abdomen weight loss for no reason pain in your side that does not go away loss of appetite treatment depends on your age, your overall health and how advanced the cancer is. it might include surgery, chemotherapy, or radiation, biologic, or targeted therapies. biologic therapy boosts your body's own ability to fight cancer. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Kidney Cancer, also known as renal cell carcinoma, is related to adenocarcinoma and prostate cancer. An important gene associated with Kidney Cancer is RNF139 (ring finger protein 139). The drugs hydroxyurea and interferon alfa-2a and the compounds fumarate and sunitinib have been mentioned in the context of this disorder. Affiliated tissues include the kidney, kidney and prostate, and related mouse phenotype liver/biliary system.

Disease Ontology:8 A urinary system cancer that is located in the kidney.

Wikipedia:63 Kidney cancer is a type of cancer that starts in the cells in the kidney. more...

Description from OMIM:46 144700

Aliases & Classifications for Kidney Cancer

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8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

kidney cancer 8 42 10 33
renal cell carcinoma 46 10 60
renal cancer 8 42 44
renal cell carcinoma 1 42 60
malignant neoplasm of kidney except pelvis 8
conventional renal cell carcinoma 60
malignant neoplasm of kidney 60
malignant tumour of kidney 8
renal adenocarcinoma 42
carcinoma renal cell 44
renal cell cancer 42
hypernephroma 42


External Ids:

Disease Ontology8 DOID:263
NCIt39 C3150
MeSH34 D007680

Related Diseases for Kidney Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Kidney Cancer family:

Kidney Carcinoma in Situ Kidney Benign Neoplasm

Diseases related to Kidney Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 402)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.6HNF1B, VHL
2prostate cancer30.5HNF1B, FH, FABP1
3obesity30.3PLIN2, FABP1, HNF1A
4renal oncocytoma30.2FLCN
5cystic kidney30.2HNF1B, VHL, FH
6kidney rhabdoid cancer30.1VHL, IFNA1, FH, FLCN, IL2, PLIN2
7fumarate hydratase deficiency30.1FH
8leiomyomatosis30.0FH, VHL
9leiomyoma29.9FLCN, FH
10hepatitis29.8IFNA1
11colorectal cancer29.7HNF1A, IFNA1, FABP1, IL2, GSTM3
12adenoma29.7HNF1A, VHL, FABP1
13hepatocellular carcinoma29.7FABP1, IFNA1, HNF1B, HNF1A
14angiomyolipoma10.8
15bone carcinoma10.8
16small cell carcinoma10.7
17renal adenoma10.6
18parathyroid carcinoma10.6
19hemangioblastoma10.6
20adrenal carcinoma10.6
21nonpapillary renal cell carcinoma10.6
22large cell carcinoma10.5
23sarcoma10.5
24xanthogranulomatous pyelonephritis10.5
25glomerulonephritis10.5
26in situ carcinoma10.5
27pyelonephritis10.5
28multilocular clear cell renal cell carcinoma10.5
29hypercalcemia10.5
30papillary adenoma10.5
31mucinous tubular and spindle renal cell carcinoma10.5
32eosinophilic variant of chromophobe renal cell carcinoma10.5
33adrenocortical carcinoma10.5
34kidney disease10.5
35renal wilms' tumor10.4
36familial renal cell carcinoma10.4
37renal cell carcinoma10.4
38spindle cell carcinoma10.4
39metanephric adenoma10.4
40hereditary conventional renal cell carcinoma10.4
41polycystic kidney disease10.4
42autosomal dominant disease10.4
43kidney angiomyolipoma10.4
44papillary thyroid carcinoma10.4
45squamous cell carcinoma10.4
46polycystic kidney disease, autosomal dominant10.4
47renal cell carcinoma, papillary, 110.4
48cervicitis10.3
49meningioma10.3
50neuroblastoma10.3

Graphical network of the top 20 diseases related to Kidney Cancer:



Diseases related to kidney cancer

Clinical Features for Kidney Cancer

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Sources:
46OMIM
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Clinical features from OMIM:

144700

Drugs & Therapeutics for Kidney Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Kidney Cancer

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Anatomical Context for Kidney Cancer

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Kidney Cancer:

32
Kidney, Prostate, Lung, Skin, Breast, Endothelial, Colon, Testes, Liver, Heart, Bone, Pancreas, T cells, Monocytes, Cortex, Testis, Eye, Ovary, Brain, Lymph node

FMA organs/tissues related to Kidney Cancer:

14
The kidney

Animal Models for Kidney Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Kidney Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537010.5PLIN2, IL2, FABP1, VHL, HNF1B, HNF1A

Publications for Kidney Cancer

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50PubMed
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Articles related to Kidney Cancer:

(show top 50)    (show all 605)
idTitleAuthorsYear
1
Reduced risk of incident kidney cancer from walking and running. (23863620)
2014
2
Hereditary kidney cancer syndromes. (24359990)
2014
3
The association of pioglitazone and urinary tract disease in type 2 diabetic taiwanese: bladder cancer and chronic kidney disease. (24427312)
2014
4
Kidney cancer and diabetes mellitus: a population-based case-control study in Taiwan. (23604500)
2013
5
Analgesic use and the risk of kidney cancer: A meta-analysis of epidemiologic studies. (23400756)
2013
6
Nicotine induces alteration of H3K27 demethylase UTX in kidney cancer cell. (23925944)
2013
7
Impact of chronic kidney disease on the risk of clinical outcomes in patients with cancer-associated venous thromboembolism during anticoagulant treatment. (24112123)
2013
8
Manual repositioning of intra-atrial kidney cancer tumor thrombus: a technique reducing the need for cardiopulmonary bypass. (23414691)
2013
9
Kidney cancer in 2012: new frontiers in kidney cancer research. (23318364)
2013
10
Incidence, predictive factors, and clinical outcomes of acute kidney injury after gastric surgery for gastric cancer. (24349249)
2013
11
Kidney cancer: Low serum sodium linked to poor outcomes for patients with mRCC treated with targeted therapy. (24217674)
2013
12
3rd Pavia international symposium on advanced kidney cancer. (22263875)
2012
13
Sirolimus and secondary skin-cancer prevention in kidney transplantation. (22830463)
2012
14
Kidney cancer: Is incomplete renal ablation linked to tumour progression? (22926423)
2012
15
Management of kidney cancer: canadian kidney cancer forum consensus update 2011. (22396361)
2012
16
Trends in the kidney cancer incidence and mortality in the Slovak and Czech Republics in 1980-2005 - in the context of an international comparison. (21288054)
2011
17
Urine metabolomics for kidney cancer detection and biomarker discovery. (21930086)
2011
18
Immunological effects of multikinase inhibitors for kidney cancer: a clue for integration with cellular therapies? (21716852)
2011
19
Associations between physical activity and quality of life in a population-based sample of kidney cancer survivors. (21467240)
2011
20
Efficacy of sunitinib rechallenge in kidney cancer: are mTOR inhibitors involved or is it only a matter of time? (21625181)
2011
21
Safety and efficacy of molecularly targeted agents in patients with metastatic kidney cancer with renal dysfunction. (21799472)
2011
22
Ionizing radiation and kidney cancer among Japanese atomic bomb survivors. (20518663)
2010
23
Circulating 25-hydroxyvitamin D and risk of kidney cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. (20562187)
2010
24
Impact of immunotherapy in metastatic kidney cancer in Germany after introduction of new target therapy--results of a telephone survey of the German Society of Immuno- and Targeted Therapy (DGFIT)]. (19937556)
2010
25
Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer. (19626587)
2010
26
Molecular diagnosis and therapy of kidney cancer. (20059341)
2010
27
How useful is alpha-methylacyl-CoA racemase (AMACR) immunohistochemistry in the differential diagnosis of kidney cancers? (20102405)
2010
28
Kidney cancer: Postoperative CRP predicts RCC outcome after nephrectomy. (21113993)
2010
29
Direct infusion mass spectrometry or liquid chromatography mass spectrometry for human metabonomics? A serum metabonomic study of kidney cancer. (20856980)
2010
30
What is new in kidney cancer? (19954286)
2009
31
Non-contrast MRI for the evaluation of hydronephrotic and dysfunctioning kidney secondary to testicular cancer. (19212914)
2009
32
Functional significance of Wnt inhibitory factor-1 gene in kidney cancer. (19887605)
2009
33
MicroRNA profiling of human kidney cancer subtypes. (19513557)
2009
34
The contemporary role of surgery in kidney cancer. (19478900)
2009
35
Case of drug-induced colitis like ulcerative colitis during IL-2 therapy for multiple bone metastasis after operation of kidney cancer]. (19663247)
2009
36
Urine metabolomics analysis for kidney cancer detection and biomarker discovery. (19008263)
2009
37
Bibliography. Current world literature. Kidney cancer. (18670281)
2008
38
Kidney cancer: opportunity for disease specific targeted therapy. (18774470)
2008
39
Kidney cancer in American Indian and native Alaskan men and women-time to notice, time to care. (18718642)
2008
40
New challenges in kidney cancer therapy: bevacizumab. (17631602)
2007
41
Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study. (17617661)
2007
42
Cytokine-based immunotherapy for advanced kidney cancer: past results and future perspectives in the era of molecularly targeted agents. (17619768)
2007
43
Treatment for advanced kidney cancer. (16673450)
2006
44
Prognostic factors in patients with advanced renal cell carcinoma: development of an international kidney cancer working group. (15448023)
2004
45
Bibliography. Current world literature. Kidney cancer. (15332298)
2004
46
Differential expression of the enzyme that esterifies retinol, lecithin:retinol acyltransferase, in subtypes of human renal cancer and normal kidney. (14581364)
2003
47
Obesity, interrelated mechanisms, and exposures and kidney cancer. (11769879)
2001
48
Kidney metastasis of lung cancer presenting as renal carbuncle. (10368265)
1999
49
Induction of nuclear catechol-O-methyltransferase by estrogens in hamster kidney: implications for estrogen-induced renal cancer. (9683193)
1998
50
The diagnostic validity of the serum tumor marker phosphohexose isomerase (PHI) in patients with gastrointestinal, kidney, and breast cancer. (2207761)
1990

Genetic Variations for Kidney Cancer

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Kidney Cancer:

62
id Symbol AA change Variation ID SNP ID
1FLCNp.Arg239CysVAR_066026rs78683075
2VHLp.Leu163ProVAR_034998rs28940297

Expression for genes affiliated with Kidney Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Kidney Cancer

Search GEO for disease gene expression data for Kidney Cancer.

Pathways for genes affiliated with Kidney Cancer

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Compounds for genes affiliated with Kidney Cancer

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44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Kidney Cancer according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1fumarate44 1111.8IL2, FH, VHL
2sunitinib44 49 1112.7VHL, IFNA1, IL2
3nnmt4410.7HNF1B, HNF1A
4fatty acid4410.7HNF1A, S100A7, FH, FABP1, PLIN2
5sorafenib44 49 1112.7IL2, IFNA1, VHL
6mizoribine4410.7IFNA1, IL2
7intron a4410.7IFNA1, IL2
8denileukin diftitox44 49 1112.6IFNA1, IL2
9phosphoenolpyruvate44 1111.6FABP1, FH, HNF1A
10pentostatin44 59 28 1113.5IL2, IFNA1
11glatiramer acetate44 1111.5IL2, IFNA1
12retinoic acid44 2411.5HNF1A, HNF1B, IFNA1, NDUFA13, S100A7, FABP1
13glucose4410.4FABP1, HNF1B, HNF1A
14rapamycin4410.2VHL, IFNA1, FLCN, IL2

GO Terms for genes affiliated with Kidney Cancer

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16Gene Ontology
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Biological processes related to Kidney Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of pronephros sizeGO:03556510.5HNF1B, HNF1A
2negative regulation of cell growthGO:03030810.5GDF9, FLCN, NDUFA13
3positive regulation of transcription initiation from RNA polymerase II promoterGO:06026110.4HNF1B, HNF1A
4regulation of Wnt receptor signaling pathwayGO:03011110.2HNF1B, HNF1A

Products for genes affiliated with Kidney Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Kidney Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet