MCID: KDN017
MIFTS: 68

Kidney Cancer malady

Genetic diseases, Rare diseases, Cancer diseases, Nephrological diseases categories
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Summaries for Kidney Cancer

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Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 You have two kidneys. they are fist-sized organs on either side of your backbone above your waist. the tubes inside filter and clean your blood, taking out waste products and making urine. kidney cancer forms in the lining of tiny tubes inside your kidneys. kidney cancer becomes more likely as you age. risk factors include smoking, having certain genetic conditions, and misusing pain medicines for a long time. you may have no symptoms at first. they may appear as the cancer grows. see your health care provider if you notice blood in your urine a lump in your abdomen weight loss for no reason pain in your side that does not go away loss of appetite treatment depends on your age, your overall health and how advanced the cancer is. it might include surgery, chemotherapy, or radiation, biologic, or targeted therapies. biologic therapy boosts your body's own ability to fight cancer. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Kidney Cancer, also known as renal cell carcinoma, is related to polycystic kidney disease and cystadenoma. An important gene associated with Kidney Cancer is RNF139 (ring finger protein 139), and among its related pathways are Cytokine Network and Regulation of Hypoxia-inducible Factor (HIF) by Oxygen. The drugs hydroxyurea and interferon alfa-2a and the compounds nnmt and mizoribine have been mentioned in the context of this disorder. Affiliated tissues include the kidney, kidney and prostate, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Disease Ontology:8 A urinary system cancer that is located in the kidney.

Wikipedia:65 Kidney cancer is a type of cancer that starts in the cells in the kidney. more...

Description from OMIM:47 144700

Aliases & Classifications for Kidney Cancer

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62UMLS, 8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 34MedlinePlus, 45Novoseek, 47OMIM, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:



Aliases & Descriptions:

kidney cancer 8 43 10 34
renal cell carcinoma 47 10 62
renal cancer 8 43 45
renal cell carcinoma 1 43 62
malignant neoplasm of kidney except pelvis 8
conventional renal cell carcinoma 62
malignant neoplasm of kidney 62
malignant tumour of kidney 8
renal adenocarcinoma 43
carcinoma renal cell 45
renal cell cancer 43
hypernephroma 43


External Ids:

Disease Ontology8 DOID:263
NCIt40 C3150
MeSH35 D007680

Related Diseases for Kidney Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Kidney Cancer family:

Kidney Carcinoma in Situ Kidney Benign Neoplasm

Diseases related to Kidney Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 408)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic kidney disease30.6VHL, HNF1B
2cystadenoma30.6VHL
3ovarian cancer30.4EFS, IL2, VHL, HNF1B
4fumarate hydratase deficiency30.3FH
5astrocytoma30.3EFS, VHL, CA9, GSTM3
6breast cancer30.3FABP1, IL2, VHL, CA9, HNF1A, GSTM3
7cystic kidney30.3FH, VHL, HNF1B
8leiomyomatosis30.2FH, VHL
9hairy cell leukemia30.2IL2, IFNA1
10hepatitis b30.1HNF1A, IL2, IFNA1
11lung cancer30.0GSTM3, HNF1A, CA9, VHL, EFS
12renal clear cell carcinoma29.9CA9, VHL, FH
13colorectal cancer29.7GSTM3, HNF1A, CA9, IL2, IFNA1, FABP1
14prostate cancer29.7EFS, FABP1, FH, CA9, HNF1B
15sarcomatoid renal cell carcinoma11.0
16renal oncocytoma10.9
17multilocular cystic renal cell carcinoma10.9
18angiomyolipoma10.8
19clear cell papillary renal cell carcinoma10.8
20familial renal cell carcinoma10.7
21renal cell carcinoma, clear cell, somatic10.7
22hereditary renal cell carcinoma10.7
23hemangioblastoma10.6
24nonpapillary renal cell carcinoma10.6
25chromophil renal cell carcinoma10.6
26xanthogranulomatous pyelonephritis10.5
27glomerulonephritis10.5
28pyelonephritis10.5
29sarcoma10.5
30hypercalcemia10.5
31paraneoplastic syndromes10.5
32adenocarcinoma10.5
33renal cell carcinoma 410.5
34renal cell carcinoma10.4
35metanephric adenoma10.4
36mucinous tubular and spindle cell carcinoma10.4
37spindle cell carcinoma10.4
38adrenocortical carcinoma10.4
39renal cell carcinoma, papillary, 110.4
40meningioma10.4
41melanoma10.3
42prostatitis10.3
43cystic nephroma10.3
44eosinophilic variant of chromophobe renal cell carcinoma10.3
45neuronitis10.3
46gastrointestinal stromal tumor10.3
47alveolar soft part sarcoma10.3
48papillary adenoma10.3
49cervicitis10.3
50chromophobe adenocarcinoma10.3

Graphical network of the top 20 diseases related to Kidney Cancer:



Diseases related to kidney cancer

Symptoms for Kidney Cancer

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Sources:
47OMIM
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Clinical features from OMIM:

144700

Drugs & Therapeutics for Kidney Cancer

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Kidney Cancer

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Anatomical Context for Kidney Cancer

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Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to Kidney Cancer:

33
Kidney, Prostate, Endothelial, Testes, Lung, Colon, Liver, Lymph node, Breast, Bone, Eye, Monocytes, T cells

FMA organs/tissues related to Kidney Cancer:

14
The kidney

Animal Models for Kidney Cancer or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Kidney Cancer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.0EFS, FLCN, FH, VHL, HNF1B, HNF1A
2MP:00053709.0HNF1A, EFS, FABP1, IL2, PLIN2, VHL
3MP:00053798.9GDF9, IL2, PLIN2, VHL, CA9, HNF1B
4MP:00053768.7FLCN, FABP1, IL2, PLIN2, FH, VHL

Publications for Kidney Cancer

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Sources:
52PubMed
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Articles related to Kidney Cancer:

(show top 50)    (show all 520)
idTitleAuthorsYear
1
Urology and nephrology update: bladder and kidney cancer. (24432708)
2014
2
Molecular pathways: Fumarate hydratase-deficient kidney cancer--targeting the Warburg effect in cancer. (23633457)
2013
3
Diagnosis and management of BHD-associated kidney cancer. (23703644)
2013
4
Evaluation of awareness of risk factors for kidney cancer among patients presenting to a urology clinic. (24328689)
2013
5
Kidney cancer: New AUA guideline tackles follow-up monitoring of small renal masses. (23712208)
2013
6
A population-based study on the association between urinary calculi and kidney cancer. (24282464)
2013
7
Inhibition of PPARI+ induces cell cycle arrest and apoptosis, and synergizes with glycolysis inhibition in kidney cancer cells. (23951092)
2013
8
Aurora A overexpression and pVHL reduced expression are correlated with a bad kidney cancer prognosis. (23151618)
2012
9
Higher perioperative morbidity and in-hospital mortality in patients with end-stage renal disease undergoing nephrectomy for non-metastatic kidney cancer: a population-based analysis. (22321256)
2012
10
Management of kidney cancer in Asia: resource-stratified guidelines from the Asian Oncology Summit 2012. (23117003)
2012
11
Words of wisdom. Re: Long-term survival following partial vs radical nephrectomy among older patients with early-stage kidney cancer. (22748396)
2012
12
Loss of expression of growth differentiation factor-9 (GDF9) in human kidney cancer and regulation of growth and migration of kidney cancer cells by GDF9. (23060562)
2012
13
Re: Thermal ablation vs surgery for localized kidney cancer: a surveillance, epidemiology, and end results (seer) database analysis. (22153419)
2012
14
3rd Pavia international symposium on advanced kidney cancer. (22263875)
2012
15
Kidney cancer: assessing the management of localized kidney cancer. (22430168)
2012
16
Re: Higher perioperative morbidity and in-hospital mortality in patients with end-stage renal disease undergoing nephrectomy for non-metastatic kidney cancer: a population-based analysis. (22784717)
2012
17
Trends in the kidney cancer incidence and mortality in the Slovak and Czech Republics in 1980-2005 - in the context of an international comparison. (21288054)
2011
18
Kidney cancer: Incorporating new parameters into pathological staging of RCC. (21743445)
2011
19
Prognostic model for survival in patients with metastatic renal cell carcinoma: results from the international kidney cancer working group. (21828239)
2011
20
Fatty acid binding proteins (FABPs) in prostate, bladder and kidney cancer cell lines and the use of IL-FABP as survival predictor in patients with renal cell carcinoma. (21767383)
2011
21
Insulin-like growth factors and risk of kidney cancer in men. (20517306)
2010
22
Management of locally recurrent kidney cancer. (20425632)
2010
23
Kidney Cancer Working Group report. (20870920)
2010
24
Ionizing radiation and kidney cancer among Japanese atomic bomb survivors. (20518663)
2010
25
Systemic therapy of kidney cancer: tyrosine kinase inhibitors, antiangiogenesis or IL-2? (19663736)
2009
26
Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer. (19194507)
2009
27
Kidney cancer in the elderly. (19879478)
2009
28
What is new in kidney cancer? (19954286)
2009
29
NICE recommends kidney cancer drug it previously rejected on cost grounds. (19204038)
2009
30
What's new in 2008 in kidney cancer?]. (19447330)
2009
31
Canadian kidney cancer forum 2008. (18682767)
2008
32
Antisense attenuation of p21 sensitizes kidney cancer to apoptosis in response to conventional DNA damaging chemotherapy associated with enhancement of phospho-p53. (18499163)
2008
33
Low-dose cyclophosphamide and continuous-infusion interleukin-2 with famotidine in previously treated metastatic melanoma or kidney cancer. (18298334)
2008
34
Major treatment improvements encourage kidney cancer researchers to seek further gains. (18728277)
2008
35
New challenges in kidney cancer therapy: bevacizumab. (17631602)
2007
36
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer. (17287871)
2007
37
18-year recurrence-free survival after extensive surgery for kidney cancer with atrial tumor thrombi. (17880301)
2007
38
Family history and the risk of kidney cancer: a multicenter case-control study in Central Europe. (17548699)
2007
39
Gene expression profiling in kidney cancer: combining differential expression and chromosomal and pathway analyses. (17239277)
2006
40
Promoter hypermethylation profile of kidney cancer with new proapoptotic p53 target genes and clinical implications. (16951219)
2006
41
Kidney cancer: identification of novel targets for therapy. (16408110)
2006
42
The effect of hypertension on the risk for kidney cancer in Korean men. (15673312)
2005
43
Allogeneic gene-modified tumour cells in metastatic kidney cancer. Report II. (15709712)
2004
44
Promoter hypermethylation profile of kidney cancer. (15217927)
2004
45
Generation of kidney cancer-specific antitumor immune responses using peripheral blood monocytes transduced with a recombinant adenovirus encoding carbonic anhydrase 9. (14977845)
2004
46
Mitochondrial targeting of human 8-oxoguanine DNA glycosylase hOGG1 is impaired by a somatic mutation found in kidney cancer. (12509224)
2002
47
Kidney cancer: the Cytokine Working Group experience (1986-2001): part I. IL-2-based clinical trials. (11917944)
2001
48
Expression of the plasminogen activation system in kidney cancer correlates with its aggressive phenotype. (9563880)
1998
49
Health related quality of life outcomes in patients treated for metastatic kidney cancer: a pilot study. (9112487)
1997
50
Treatment with tumor necrosis factor alpha and interferon alpha of a human kidney cancer xenograft in nude mice: evidence for an anticachectic effect of interferon alpha. (8166454)
1994

Variations for Kidney Cancer

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Sources:
64UniProtKB/Swiss-Prot, 7dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Kidney Cancer:

64
id Symbol AA change Variation ID SNP ID
1FLCNp.Arg239CysVAR_066026rs78683075
2VHLp.Leu163ProVAR_034998rs28940297

Expression for genes affiliated with Kidney Cancer

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Kidney Cancer

Search GEO for disease gene expression data for Kidney Cancer.

Pathways for genes affiliated with Kidney Cancer

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Sources:
50PathCards, 53QIAGEN, 55Reactome, 30KEGG, 5Cell Signaling Technology
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Compounds for genes affiliated with Kidney Cancer

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Kidney Cancer according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1nnmt4510.5HNF1B, HNF1A
2mizoribine4510.4IL2, IFNA1
3intron a4510.3IL2, IFNA1
4denileukin diftitox45 51 1112.3IFNA1, IL2
5pentostatin45 61 29 1113.3IL2, IFNA1
6fumarate45 1111.3VHL, FH, IL2
7glatiramer acetate45 1111.3IFNA1, IL2
8levamisole45 1111.3IFNA1, IL2
9phosphoenolpyruvate45 1111.2FABP1, FH, HNF1A
10dacarbazine45 1111.2IL2, IFNA1
11sunitinib45 51 1112.2IFNA1, IL2, VHL
12sorafenib45 51 1112.2VHL, IL2, IFNA1
13il-124510.2IFNA1, IL2
14isotretinoin45 1111.0IL2, IFNA1
15cyclophosphamide45 51 1112.0GSTM3, IL2, IFNA1
16temozolomide45 1110.9IFNA1, IL2
17sterol459.9HNF1A, PLIN2, FABP1
18fatty acid459.9HNF1A, FH, PLIN2, FABP1
19bcnu459.7IL2, IFNA1
205-aza-2deoxycytidine459.7CA9, VHL, IFNA1
21oligonucleotide459.7EFS, FABP1, VHL, HNF1B, HNF1A
22proline459.7HNF1A, CA9, VHL, FH, EFS
23retinoic acid45 2410.5FABP1, IFNA1, HNF1B, HNF1A, NDUFA13
24oxygen45 2410.4EFS, FH, VHL, CA9, GSTM3
25rapamycin459.4CA9, VHL, IL2, IFNA1, FLCN, EFS
26glucose459.3FABP1, PLIN2, FH, VHL, CA9, HNF1B
27tyrosine459.1EFS, IFNA1, IL2, FH, VHL, CA9
28vegf459.0EFS, FABP1, IFNA1, IL2, PLIN2, VHL

GO Terms for genes affiliated with Kidney Cancer

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16Gene Ontology
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Biological processes related to Kidney Cancer according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of pronephros sizeGO:03556510.3HNF1A, HNF1B
2positive regulation of transcription initiation from RNA polymerase II promoterGO:06026110.3HNF1A, HNF1B
3insulin secretionGO:03007310.2HNF1A, HNF1B
4negative regulation of cell growthGO:0303089.9NDUFA13, FLCN, GDF9
5cellular response to hypoxiaGO:0714569.8FABP1, VHL, CA9
6regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.7CA9, VHL
7small molecule metabolic processGO:0442818.9FABP1, PLIN2, FH, CA9, GSTM3, NDUFA13

Products for genes affiliated with Kidney Cancer

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Sources for Kidney Cancer

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet