MCID: KDN017
MIFTS: 53

Kidney Cancer malady

Rare diseases, Nephrological diseases, Cancer diseases categories

Summaries for Kidney Cancer

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MedlinePlus:32 You have two kidneys. they are fist-sized organs on either side of your backbone above your waist. the tubes inside filter and clean your blood, taking out waste products and making urine. kidney cancer forms in the lining of tiny tubes inside your kidneys. kidney cancer becomes more likely as you age. risk factors include smoking, having certain genetic conditions, and misusing pain medicines for a long time. you may have no symptoms at first. they may appear as the cancer grows. see your health care provider if you notice blood in your urine a lump in your abdomen weight loss for no reason pain in your side that does not go away loss of appetite treatment depends on your age, your overall health and how advanced the cancer is. it might include surgery, chemotherapy, or radiation, biologic, or targeted therapies. biologic therapy boosts your body's own ability to fight cancer. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards based summary: Kidney Cancer, also known as renal cancer, is related to renal cell carcinoma and fumarate hydratase deficiency. An important gene associated with Kidney Cancer is IL2 (interleukin 2), and among its related pathways is Renal cell carcinoma. The drugs hydroxyurea and interferon alfa-2a and the compounds sunitinib and sorafenib have been mentioned in the context of this disorder. Affiliated tissues include the kidney, kidney and prostate, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:9 A urinary system cancer that is located in the kidney.

Wikipedia:63 Kidney cancer is a type of cancer that starts in the cells in the kidney. more...

Aliases & Classifications for Kidney Cancer

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Kidney Cancer, Aliases & Descriptions:

Name: Kidney Cancer 9 41 11 32
Renal Cancer 9 41 43
Renal Cell Carcinoma 1 41 60
Malignant Neoplasm of Kidney Except Pelvis 9
Conventional Renal Cell Carcinoma 60
Malignant Neoplasm of Kidney 60
Malignant Tumour of Kidney 9
 
Renal Cell Carcinoma 60
Renal Adenocarcinoma 41
Carcinoma Renal Cell 43
Renal Cell Cancer 41
Renal Carcinoma 60
Hypernephroma 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Nephrological diseases


External Ids:

Disease Ontology9 DOID:263
MeSH33 D007680
NCIt38 C3150

Related Diseases for Kidney Cancer

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Diseases in the Kidney Cancer family:

Kidney Carcinoma in Situ Kidney Benign Neoplasm

Diseases related to Kidney Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1renal cell carcinoma31.0VHL, FLCN
2fumarate hydratase deficiency30.8FH
3cystic kidney30.5VHL, FH
4leiomyomatosis30.4FH, VHL
5leiomyoma30.1FH, FLCN
6renal clear cell carcinoma29.8VHL, FH
7colorectal cancer29.4FABP1, IL2, GSTM3
8adenocarcinoma10.7
9prostatitis10.4
10melanoma10.4
11cystadenoma10.3VHL
12obesity10.3
13leiomyomatosis and renal cell cancer10.3
14endotheliitis10.2
15pneumothorax10.2
16leukemoid reaction10.1
17hypoxia10.1
18spontaneous pneumothorax10.1
19paraganglioma10.1FH, VHL
20wilms tumor10.1
21ulcerative colitis10.1
22collecting duct carcinoma10.1
23colitis10.1
24spindle cell carcinoma10.0
25sarcomatoid renal cell carcinoma10.0
26adrenocortical carcinoma10.0
27clear cell papillary renal cell carcinoma10.0
28thyroiditis10.0
29lung cancer10.0
30hematopoietic stem cell transplantation10.0
31hereditary hemorrhagic telangiectasia10.0
32verrucous carcinoma10.0
33angioedema10.0
34interstitial nephritis10.0
35myopathy10.0
36castleman's disease10.0
37wells syndrome10.0
38nephritis10.0
39epididymitis10.0
40oxyphilic adenoma10.0VHL, FH, FLCN
41alveolar soft-part sarcoma10.0
42chronic lymphocytic leukemia10.0
43lymphomatoid granulomatosis10.0
44luteoma10.0
45hypoglycemia10.0
46siderosis10.0
47renal tuberculosis10.0
48psoriasis10.0
49sarcoma10.0
50tuberculosis10.0

Graphical network of the top 20 diseases related to Kidney Cancer:



Diseases related to kidney cancer

Symptoms for Kidney Cancer

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Drugs & Therapeutics for Kidney Cancer

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Genetic Tests for Kidney Cancer

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Anatomical Context for Kidney Cancer

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MalaCards organs/tissues related to Kidney Cancer:

31
Kidney, Prostate, Endothelial, Testes, Lymph node, Lung, Neutrophil, Eye, Bone, Colon, Liver, Breast, Monocytes, Nk cells, T cells

FMA organs/tissues related to Kidney Cancer:

14
The kidney

Animal Models for Kidney Cancer or affiliated genes

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MGI Mouse Phenotypes related to Kidney Cancer:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0VHL, FH, IL2, FABP1, FLCN, GDF9

Publications for Kidney Cancer

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Articles related to Kidney Cancer:

(show top 50)    (show all 558)
idTitleAuthorsYear
1
Endovascular Extraction of Caval Tumor Thrombus to Facilitate Minimally Invasive Cytoreductive Nephrectomy for Metastatic Kidney Cancer. (25843640)
2015
2
Reply to Marc Bjurlin, Elena Elkin, and William Huang's Letter to the Editor re: Maxine Sun, Andreas Becker, Zhe Tian, et al. Management of Localized Kidney Cancer: Calculating Cancer-specific Mortality and Competing Risks of Death for Surgery and Nonsurgical Management. Eur Urol 2014;65:235-41. (25179937)
2014
3
Kidney cancer: Routine small renal mass needle biopsy should be adopted. (25155789)
2014
4
Metadherin in prostate, bladder, and kidney cancer: A systematic review. (25279212)
2014
5
Decade in review-kidney cancer: Discoveries, therapies and opportunities. (25287783)
2014
6
Urology and nephrology update: bladder and kidney cancer. (24432708)
2014
7
Kidney cancer: Prognostic nutritional index predicts survival. (25311678)
2014
8
Molecular pathways: Fumarate hydratase-deficient kidney cancer--targeting the Warburg effect in cancer. (23633457)
2013
9
Diagnosis and management of BHD-associated kidney cancer. (23703644)
2013
10
Evaluation of awareness of risk factors for kidney cancer among patients presenting to a urology clinic. (24328689)
2013
11
Kidney cancer: New AUA guideline tackles follow-up monitoring of small renal masses. (23712208)
2013
12
Aurora A overexpression and pVHL reduced expression are correlated with a bad kidney cancer prognosis. (23151618)
2012
13
Higher perioperative morbidity and in-hospital mortality in patients with end-stage renal disease undergoing nephrectomy for non-metastatic kidney cancer: a population-based analysis. (22321256)
2012
14
Management of kidney cancer in Asia: resource-stratified guidelines from the Asian Oncology Summit 2012. (23117003)
2012
15
Words of wisdom. Re: Long-term survival following partial vs radical nephrectomy among older patients with early-stage kidney cancer. (22748396)
2012
16
Loss of expression of growth differentiation factor-9 (GDF9) in human kidney cancer and regulation of growth and migration of kidney cancer cells by GDF9. (23060562)
2012
17
Re: Thermal ablation vs surgery for localized kidney cancer: a surveillance, epidemiology, and end results (seer) database analysis. (22153419)
2012
18
3rd Pavia international symposium on advanced kidney cancer. (22263875)
2012
19
Kidney cancer: assessing the management of localized kidney cancer. (22430168)
2012
20
Re: Higher perioperative morbidity and in-hospital mortality in patients with end-stage renal disease undergoing nephrectomy for non-metastatic kidney cancer: a population-based analysis. (22784717)
2012
21
Trends in the kidney cancer incidence and mortality in the Slovak and Czech Republics in 1980-2005 - in the context of an international comparison. (21288054)
2011
22
Kidney cancer: Incorporating new parameters into pathological staging of RCC. (21743445)
2011
23
Prognostic model for survival in patients with metastatic renal cell carcinoma: results from the international kidney cancer working group. (21828239)
2011
24
Insulin-like growth factors and risk of kidney cancer in men. (20517306)
2010
25
Management of locally recurrent kidney cancer. (20425632)
2010
26
Kidney Cancer Working Group report. (20870920)
2010
27
Ionizing radiation and kidney cancer among Japanese atomic bomb survivors. (20518663)
2010
28
Systemic therapy of kidney cancer: tyrosine kinase inhibitors, antiangiogenesis or IL-2? (19663736)
2009
29
Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer. (19194507)
2009
30
Kidney cancer in the elderly. (19879478)
2009
31
What is new in kidney cancer? (19954286)
2009
32
NICE recommends kidney cancer drug it previously rejected on cost grounds. (19204038)
2009
33
Canadian kidney cancer forum 2008. (18682767)
2008
34
Antisense attenuation of p21 sensitizes kidney cancer to apoptosis in response to conventional DNA damaging chemotherapy associated with enhancement of phospho-p53. (18499163)
2008
35
Low-dose cyclophosphamide and continuous-infusion interleukin-2 with famotidine in previously treated metastatic melanoma or kidney cancer. (18298334)
2008
36
Major treatment improvements encourage kidney cancer researchers to seek further gains. (18728277)
2008
37
New challenges in kidney cancer therapy: bevacizumab. (17631602)
2007
38
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer. (17287871)
2007
39
18-year recurrence-free survival after extensive surgery for kidney cancer with atrial tumor thrombi. (17880301)
2007
40
Family history and the risk of kidney cancer: a multicenter case-control study in Central Europe. (17548699)
2007
41
Gene expression profiling in kidney cancer: combining differential expression and chromosomal and pathway analyses. (17239277)
2006
42
Promoter hypermethylation profile of kidney cancer with new proapoptotic p53 target genes and clinical implications. (16951219)
2006
43
The effect of hypertension on the risk for kidney cancer in Korean men. (15673312)
2005
44
Allogeneic gene-modified tumour cells in metastatic kidney cancer. Report II. (15709712)
2004
45
Promoter hypermethylation profile of kidney cancer. (15217927)
2004
46
Generation of kidney cancer-specific antitumor immune responses using peripheral blood monocytes transduced with a recombinant adenovirus encoding carbonic anhydrase 9. (14977845)
2004
47
Mitochondrial targeting of human 8-oxoguanine DNA glycosylase hOGG1 is impaired by a somatic mutation found in kidney cancer. (12509224)
2002
48
Kidney cancer: the Cytokine Working Group experience (1986-2001): part I. IL-2-based clinical trials. (11917944)
2001
49
Health related quality of life outcomes in patients treated for metastatic kidney cancer: a pilot study. (9112487)
1997
50
Treatment with tumor necrosis factor alpha and interferon alpha of a human kidney cancer xenograft in nude mice: evidence for an anticachectic effect of interferon alpha. (8166454)
1994

Variations for Kidney Cancer

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Expression for genes affiliated with Kidney Cancer

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Search GEO for disease gene expression data for Kidney Cancer.

Pathways for genes affiliated with Kidney Cancer

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Pathways related to Kidney Cancer according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3VHL, FH, FLCN

Compounds for genes affiliated with Kidney Cancer

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Sources:
43Novoseek, 49PharmGKB, 12DrugBank
See all sources

Compounds related to Kidney Cancer according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1sunitinib43 49 1212.0VHL, IL2
2sorafenib43 49 1211.9IL2, VHL
3succinate439.8VHL, FH
4alpha-ketoglutarate439.7VHL, FH
5fumarate43 1210.6VHL, FH, IL2
6rapamycin439.5VHL, IL2, FLCN
7phosphoenolpyruvate43 1210.2FH, FABP1

GO Terms for genes affiliated with Kidney Cancer

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Biological processes related to Kidney Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein ubiquitinationGO:00165679.4RNF139, VHL, VHLL
2cellular response to hypoxiaGO:00714569.2VHL, FABP1
3negative regulation of cell growthGO:00303089.2GDF9, FLCN, NDUFA13
4positive regulation of cell proliferationGO:00082849.1IL2, GDF9, FABP1
5negative regulation of apoptotic processGO:00430669.1FABP1, IL2, VHL
6small molecule metabolic processGO:00442818.1NDUFA13, GSTM3, FH, FABP1

Products for genes affiliated with Kidney Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Kidney Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet