MCID: KDN017
MIFTS: 70

Kidney Cancer malady

Genetic diseases, Rare diseases, Cancer diseases, Nephrological diseases categories
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Summaries for Kidney Cancer

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MedlinePlus:33 You have two kidneys. they are fist-sized organs on either side of your backbone above your waist. the tubes inside filter and clean your blood, taking out waste products and making urine. kidney cancer forms in the lining of tiny tubes inside your kidneys. kidney cancer becomes more likely as you age. risk factors include smoking, having certain genetic conditions, and misusing pain medicines for a long time. you may have no symptoms at first. they may appear as the cancer grows. see your health care provider if you notice blood in your urine a lump in your abdomen weight loss for no reason pain in your side that does not go away loss of appetite treatment depends on your age, your overall health and how advanced the cancer is. it might include surgery, chemotherapy, or radiation, biologic, or targeted therapies. biologic therapy boosts your body's own ability to fight cancer. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards based summary: Kidney Cancer, also known as renal cell carcinoma, is related to cystic kidney and cystadenoma. An important gene associated with Kidney Cancer is RNF139 (ring finger protein 139), and among its related pathways are Cytokine Network and Regulation of Hypoxia-inducible Factor (HIF) by Oxygen. The drugs hydroxyurea and interferon alfa-2a and the compounds nnmt and mizoribine have been mentioned in the context of this disorder. Affiliated tissues include the kidney, kidney and prostate, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Disease Ontology:8 A urinary system cancer that is located in the kidney.

Wikipedia:65 Kidney cancer is a type of cancer that starts in the cells in the kidney. more...

Description from OMIM:46 144700

Aliases & Classifications for Kidney Cancer

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Kidney Cancer, Aliases & Descriptions:

Name: Kidney Cancer 8 42 10 33
Renal Cell Carcinoma 46 10 62
Renal Cancer 8 42 44
Renal Cell Carcinoma 1 42 62
Hypernephroma 42 62
Malignant Neoplasm of Kidney Except Pelvis 8
 
Malignant Neoplasm of Kidney 62
Malignant Tumour of Kidney 8
Renal Adenocarcinoma 42
Carcinoma Renal Cell 44
Renal Cell Cancer 42


Classifications:



External Ids:

Disease Ontology8 DOID:263
MeSH34 D007680
NCIt39 C3150

Related Diseases for Kidney Cancer

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Diseases in the Kidney Cancer family:

Kidney Carcinoma in Situ Kidney Benign Neoplasm

Diseases related to Kidney Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 420)
idRelated DiseaseScoreTop Affiliating Genes
1cystic kidney31.2FH, VHL, HNF1B
2cystadenoma31.2VHL
3renal clear cell carcinoma31.2VHL, CA9, FH
4fumarate hydratase deficiency30.9FH
5polycystic kidney disease30.7VHL, HNF1B
6leiomyomatosis30.7FH, VHL
7astrocytoma30.6EFS, GSTM3, CA9, VHL
8hairy cell leukemia30.5IL2, IFNA1
9ovarian cancer30.5HNF1B, EFS, IL2, VHL
10colorectal cancer30.2CA9, IL2, GSTM3, IFNA1, FABP1, HNF1A
11hepatitis b30.2IL2, HNF1A, IFNA1
12breast cancer30.1IL2, GSTM3, CA9, VHL, FABP1, HNF1A
13lung cancer29.9GSTM3, HNF1A, CA9, EFS, VHL
14prostate cancer29.4FH, HNF1B, CA9, EFS, FABP1
15sarcomatoid renal cell carcinoma11.0
16renal oncocytoma10.9
17multilocular cystic renal cell carcinoma10.9
18clear cell papillary renal cell carcinoma10.9
19angiomyolipoma10.8
20familial renal cell carcinoma10.8
21thyroiditis10.7
22hereditary renal cell carcinoma10.7
23renal cell carcinoma, clear cell, somatic10.7
24hemangioblastoma10.7
25pyelonephritis10.6
26nonpapillary renal cell carcinoma10.6
27xanthogranulomatous pyelonephritis10.6
28chromophil renal cell carcinoma10.6
29sarcoma10.6
30glomerulonephritis10.6
31thrombocytosis10.5
32hypercalcemia10.5
33paraneoplastic syndromes10.5
34adenocarcinoma10.5
35renal cell carcinoma 410.5
36renal cell carcinoma10.5
37metanephric adenoma10.5
38adrenocortical carcinoma10.5
39mucinous tubular and spindle cell carcinoma10.5
40spindle cell carcinoma10.4
41renal cell carcinoma, papillary, 110.4
42tubulocystic carcinoma10.4
43familial colorectal cancer10.4VHL, FH
44sezary's disease10.4IFNA1, IL2
45oxyphilic adenoma10.4FLCN, CA9
46hemangioma10.4
47eosinophilic variant of chromophobe renal cell carcinoma10.4
48cervicitis10.4
49cholecystitis10.4
50leiomyoma10.4

Graphical network of the top 20 diseases related to Kidney Cancer:



Diseases related to kidney cancer

Symptoms for Kidney Cancer

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Clinical features from OMIM:

144700

Drugs & Therapeutics for Kidney Cancer

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Genetic Tests for Kidney Cancer

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Anatomical Context for Kidney Cancer

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MalaCards organs/tissues related to Kidney Cancer:

32
Kidney, Prostate, Endothelial, Testes, Lymph node, Lung, Neutrophil, Eye, Bone, Colon, Liver, Breast, Monocytes, Nk cells, T cells

FMA organs/tissues related to Kidney Cancer:

14
The kidney

Animal Models for Kidney Cancer or affiliated genes

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MGI Mouse Phenotypes related to Kidney Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.0EFS, FLCN, FH, VHL, HNF1B, HNF1A
2MP:00053709.0HNF1A, EFS, FABP1, IL2, PLIN2, VHL
3MP:00053798.9GDF9, IL2, PLIN2, VHL, CA9, HNF1B
4MP:00053768.7FLCN, FABP1, IL2, PLIN2, FH, VHL

Publications for Kidney Cancer

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Articles related to Kidney Cancer:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
Reply to Marc Bjurlin, Elena Elkin, and William Huang's Letter to the Editor re: Maxine Sun, Andreas Becker, Zhe Tian, et al. Management of Localized Kidney Cancer: Calculating Cancer-specific Mortality and Competing Risks of Death for Surgery and Nonsurgical Management. Eur Urol 2014;65:235-41. (25179937)
2014
2
Kidney cancer: Routine small renal mass needle biopsy should be adopted. (25155789)
2014
3
Metadherin in prostate, bladder, and kidney cancer: A systematic review. (25279212)
2014
4
Decade in review-kidney cancer: Discoveries, therapies and opportunities. (25287783)
2014
5
Urology and nephrology update: bladder and kidney cancer. (24432708)
2014
6
Kidney cancer: Prognostic nutritional index predicts survival. (25311678)
2014
7
Re: Maxine Sun, Andreas Becker, Zhe Tian, et al. Management of Localized Kidney Cancer: Calculating Cancer-specific Mortality and Competing Risks of Death for Surgery and Nonsurgical Management. Eur Urol 2014;65:235-41. (25179936)
2014
8
Contemporary incidence and mortality rates of kidney cancer in the United States. (25210548)
2014
9
Molecular pathways: Fumarate hydratase-deficient kidney cancer--targeting the Warburg effect in cancer. (23633457)
2013
10
Diagnosis and management of BHD-associated kidney cancer. (23703644)
2013
11
Evaluation of awareness of risk factors for kidney cancer among patients presenting to a urology clinic. (24328689)
2013
12
Kidney cancer: New AUA guideline tackles follow-up monitoring of small renal masses. (23712208)
2013
13
A population-based study on the association between urinary calculi and kidney cancer. (24282464)
2013
14
Aurora A overexpression and pVHL reduced expression are correlated with a bad kidney cancer prognosis. (23151618)
2012
15
Higher perioperative morbidity and in-hospital mortality in patients with end-stage renal disease undergoing nephrectomy for non-metastatic kidney cancer: a population-based analysis. (22321256)
2012
16
Management of kidney cancer in Asia: resource-stratified guidelines from the Asian Oncology Summit 2012. (23117003)
2012
17
Words of wisdom. Re: Long-term survival following partial vs radical nephrectomy among older patients with early-stage kidney cancer. (22748396)
2012
18
Loss of expression of growth differentiation factor-9 (GDF9) in human kidney cancer and regulation of growth and migration of kidney cancer cells by GDF9. (23060562)
2012
19
Re: Thermal ablation vs surgery for localized kidney cancer: a surveillance, epidemiology, and end results (seer) database analysis. (22153419)
2012
20
3rd Pavia international symposium on advanced kidney cancer. (22263875)
2012
21
Kidney cancer: assessing the management of localized kidney cancer. (22430168)
2012
22
Re: Higher perioperative morbidity and in-hospital mortality in patients with end-stage renal disease undergoing nephrectomy for non-metastatic kidney cancer: a population-based analysis. (22784717)
2012
23
Trends in the kidney cancer incidence and mortality in the Slovak and Czech Republics in 1980-2005 - in the context of an international comparison. (21288054)
2011
24
Kidney cancer: Incorporating new parameters into pathological staging of RCC. (21743445)
2011
25
Prognostic model for survival in patients with metastatic renal cell carcinoma: results from the international kidney cancer working group. (21828239)
2011
26
Insulin-like growth factors and risk of kidney cancer in men. (20517306)
2010
27
Management of locally recurrent kidney cancer. (20425632)
2010
28
Ionizing radiation and kidney cancer among Japanese atomic bomb survivors. (20518663)
2010
29
Systemic therapy of kidney cancer: tyrosine kinase inhibitors, antiangiogenesis or IL-2? (19663736)
2009
30
Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer. (19194507)
2009
31
Kidney cancer in the elderly. (19879478)
2009
32
What is new in kidney cancer? (19954286)
2009
33
NICE recommends kidney cancer drug it previously rejected on cost grounds. (19204038)
2009
34
Canadian kidney cancer forum 2008. (18682767)
2008
35
Antisense attenuation of p21 sensitizes kidney cancer to apoptosis in response to conventional DNA damaging chemotherapy associated with enhancement of phospho-p53. (18499163)
2008
36
Low-dose cyclophosphamide and continuous-infusion interleukin-2 with famotidine in previously treated metastatic melanoma or kidney cancer. (18298334)
2008
37
Major treatment improvements encourage kidney cancer researchers to seek further gains. (18728277)
2008
38
New challenges in kidney cancer therapy: bevacizumab. (17631602)
2007
39
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer. (17287871)
2007
40
Family history and the risk of kidney cancer: a multicenter case-control study in Central Europe. (17548699)
2007
41
Gene expression profiling in kidney cancer: combining differential expression and chromosomal and pathway analyses. (17239277)
2006
42
Promoter hypermethylation profile of kidney cancer with new proapoptotic p53 target genes and clinical implications. (16951219)
2006
43
The effect of hypertension on the risk for kidney cancer in Korean men. (15673312)
2005
44
Allogeneic gene-modified tumour cells in metastatic kidney cancer. Report II. (15709712)
2004
45
Promoter hypermethylation profile of kidney cancer. (15217927)
2004
46
Generation of kidney cancer-specific antitumor immune responses using peripheral blood monocytes transduced with a recombinant adenovirus encoding carbonic anhydrase 9. (14977845)
2004
47
Mitochondrial targeting of human 8-oxoguanine DNA glycosylase hOGG1 is impaired by a somatic mutation found in kidney cancer. (12509224)
2002
48
Kidney cancer: the Cytokine Working Group experience (1986-2001): part I. IL-2-based clinical trials. (11917944)
2001
49
Health related quality of life outcomes in patients treated for metastatic kidney cancer: a pilot study. (9112487)
1997
50
Treatment with tumor necrosis factor alpha and interferon alpha of a human kidney cancer xenograft in nude mice: evidence for an anticachectic effect of interferon alpha. (8166454)
1994

Variations for Kidney Cancer

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UniProtKB/Swiss-Prot genetic disease variations for Kidney Cancer:

64
id Symbol AA change Variation ID SNP ID
1FLCNp.Arg239CysVAR_066026rs78683075
2VHLp.Leu163ProVAR_034998rs28940297

Expression for genes affiliated with Kidney Cancer

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Expression patterns in normal tissues for genes affiliated with Kidney Cancer

Search GEO for disease gene expression data for Kidney Cancer.

Pathways for genes affiliated with Kidney Cancer

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Compounds for genes affiliated with Kidney Cancer

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Compounds related to Kidney Cancer according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1nnmt4410.5HNF1B, HNF1A
2mizoribine4410.4IL2, IFNA1
3intron a4410.3IL2, IFNA1
4denileukin diftitox44 50 1112.3IFNA1, IL2
5pentostatin44 61 28 1113.3IL2, IFNA1
6fumarate44 1111.3VHL, FH, IL2
7glatiramer acetate44 1111.3IFNA1, IL2
8levamisole44 1111.3IFNA1, IL2
9phosphoenolpyruvate44 1111.2FABP1, FH, HNF1A
10dacarbazine44 1111.2IL2, IFNA1
11sunitinib44 50 1112.2IFNA1, IL2, VHL
12sorafenib44 50 1112.2VHL, IL2, IFNA1
13il-124410.2IFNA1, IL2
14isotretinoin44 1111.0IL2, IFNA1
15cyclophosphamide44 50 1112.0GSTM3, IL2, IFNA1
16temozolomide44 1110.9IFNA1, IL2
17sterol449.9HNF1A, PLIN2, FABP1
18fatty acid449.9HNF1A, FH, PLIN2, FABP1
19bcnu449.7IL2, IFNA1
205-aza-2deoxycytidine449.7CA9, VHL, IFNA1
21oligonucleotide449.7EFS, FABP1, VHL, HNF1B, HNF1A
22proline449.7HNF1A, CA9, VHL, FH, EFS
23retinoic acid44 2410.5FABP1, IFNA1, HNF1B, HNF1A, NDUFA13
24oxygen44 2410.4EFS, FH, VHL, CA9, GSTM3
25rapamycin449.4CA9, VHL, IL2, IFNA1, FLCN, EFS
26glucose449.3FABP1, PLIN2, FH, VHL, CA9, HNF1B
27tyrosine449.1EFS, IFNA1, IL2, FH, VHL, CA9
28vegf449.0EFS, FABP1, IFNA1, IL2, PLIN2, VHL

GO Terms for genes affiliated with Kidney Cancer

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Biological processes related to Kidney Cancer according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of pronephros sizeGO:03556510.3HNF1A, HNF1B
2positive regulation of transcription initiation from RNA polymerase II promoterGO:06026110.3HNF1A, HNF1B
3insulin secretionGO:03007310.2HNF1B, HNF1A
4negative regulation of cell growthGO:0303089.9GDF9, FLCN, NDUFA13
5cellular response to hypoxiaGO:0714569.8CA9, FABP1, VHL
6regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.7CA9, VHL
7small molecule metabolic processGO:0442818.9FABP1, PLIN2, FH, CA9, GSTM3, NDUFA13

Products for genes affiliated with Kidney Cancer

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  • Antibodies
  • Proteins
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Sources for Kidney Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet