MCID: KDN017
MIFTS: 66

Kidney Cancer malady

Nephrological diseases, Cancer diseases categories

Summaries for Kidney Cancer

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 You have two kidneys. they are fist-sized organs on either side of your backbone above your waist. the tubes inside filter and clean your blood, taking out waste products and making urine. kidney cancer forms in the lining of tiny tubes inside your kidneys. kidney cancer becomes more likely as you age. risk factors include smoking, having certain genetic conditions, and misusing pain medicines for a long time. you may have no symptoms at first. they may appear as the cancer grows. see your health care provider if you notice blood in your urine a lump in your abdomen weight loss for no reason pain in your side that does not go away loss of appetite treatment depends on your age, your overall health and how advanced the cancer is. it might include surgery, chemotherapy, or radiation, biologic, or targeted therapies. biologic therapy boosts your body's own ability to fight cancer. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Kidney Cancer, also known as renal cell carcinoma, is related to adenocarcinoma and prostate cancer. An important gene associated with Kidney Cancer is RNF139 (ring finger protein 139). The drugs hydroxyurea and interferon alfa-2a and the compounds fumarate and sunitinib have been mentioned in the context of this disorder. Affiliated tissues include the kidney, kidney and prostate, and related mouse phenotype liver/biliary system.

Disease Ontology:8 A urinary system cancer that is located in the kidney.

Wikipedia:63 Kidney cancer is a type of cancer that starts in the cells in the kidney. more...

Description from OMIM:46 144700

Aliases & Classifications for Kidney Cancer

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

kidney cancer 8 42 10 33
renal cell carcinoma 46 10 60
renal cancer 8 42 44
renal cell carcinoma 1 42 60
malignant neoplasm of kidney except pelvis 8
conventional renal cell carcinoma 60
malignant neoplasm of kidney 60
malignant tumour of kidney 8
renal adenocarcinoma 42
carcinoma renal cell 44
renal cell cancer 42
hypernephroma 42


External Ids:

Disease Ontology8 DOID:263
NCIt39 C3150
MeSH34 D007680

Related Diseases for Kidney Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Kidney Cancer family:

Kidney Carcinoma in Situ Kidney Benign Neoplasm

Diseases related to Kidney Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 402)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.6HNF1B, VHL
2prostate cancer30.5HNF1B, FH, FABP1
3obesity30.3PLIN2, FABP1, HNF1A
4renal oncocytoma30.2FLCN
5cystic kidney30.2HNF1B, VHL, FH
6kidney rhabdoid cancer30.1VHL, IFNA1, FH, FLCN, IL2, PLIN2
7fumarate hydratase deficiency30.1FH
8leiomyomatosis30.0FH, VHL
9leiomyoma29.9FLCN, FH
10hepatitis29.8IFNA1
11colorectal cancer29.7HNF1A, IFNA1, FABP1, IL2, GSTM3
12adenoma29.7HNF1A, VHL, FABP1
13hepatocellular carcinoma29.7FABP1, IFNA1, HNF1B, HNF1A
14angiomyolipoma10.8
15bone carcinoma10.8
16small cell carcinoma10.7
17renal adenoma10.6
18parathyroid carcinoma10.6
19hemangioblastoma10.6
20adrenal carcinoma10.6
21nonpapillary renal cell carcinoma10.6
22large cell carcinoma10.5
23sarcoma10.5
24xanthogranulomatous pyelonephritis10.5
25glomerulonephritis10.5
26in situ carcinoma10.5
27pyelonephritis10.5
28multilocular clear cell renal cell carcinoma10.5
29hypercalcemia10.5
30papillary adenoma10.5
31mucinous tubular and spindle renal cell carcinoma10.5
32eosinophilic variant of chromophobe renal cell carcinoma10.5
33adrenocortical carcinoma10.5
34kidney disease10.5
35renal wilms' tumor10.4
36familial renal cell carcinoma10.4
37renal cell carcinoma10.4
38spindle cell carcinoma10.4
39metanephric adenoma10.4
40hereditary conventional renal cell carcinoma10.4
41polycystic kidney disease10.4
42autosomal dominant disease10.4
43kidney angiomyolipoma10.4
44papillary thyroid carcinoma10.4
45squamous cell carcinoma10.4
46polycystic kidney disease, autosomal dominant10.4
47renal cell carcinoma, papillary, 110.4
48cervicitis10.3
49meningioma10.3
50neuroblastoma10.3

Graphical network of the top 20 diseases related to Kidney Cancer:



Diseases related to kidney cancer

Clinical Features for Kidney Cancer

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Sources:
46OMIM
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Clinical features from OMIM:

144700

Drugs & Therapeutics for Kidney Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Kidney Cancer

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Anatomical Context for Kidney Cancer

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Kidney Cancer:

32
Kidney, Prostate, Lung, Skin, Breast, Endothelial, Colon, Testes, Liver, Heart, Bone, Pancreas, T cells, Monocytes, Cortex, Testis, Eye, Ovary, Brain, Lymph node

FMA organs/tissues related to Kidney Cancer:

14
The kidney

Animal Models for Kidney Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Kidney Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537010.5PLIN2, IL2, FABP1, VHL, HNF1B, HNF1A

Publications for Kidney Cancer

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Sources:
50PubMed
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Articles related to Kidney Cancer:

(show top 50)    (show all 605)
idTitleAuthorsYear
1
Urology and nephrology update: bladder and kidney cancer. (24432708)
2014
2
Decision-making in patients with cancer and kidney disease. (24359989)
2014
3
Kidney cancer: Tumour shrinkage of 10% is a reproducible measure in mRCC. (24346016)
2014
4
Kidney cancer: Cryoablation wins on surgical, loses on oncological results. (24296710)
2014
5
Kidney cancer cells secrete IL-8 to activate Akt and promote migration of mesenchymal stem cells. (24412633)
2014
6
A population-based study on the association between urinary calculi and kidney cancer. (24282464)
2013
7
GOAL: An inverse toxicity-related algorithm for daily clinical practice decision making in advanced kidney cancer. (24309065)
2013
8
Unusual head metastasis of kidney cancer. (24326429)
2013
9
Germline PTEN mutation Cowden syndrome: an underappreciated form of hereditary kidney cancer. (23764071)
2013
10
Optical imaging of kidney cancer with novel near infrared heptamethine carbocyanine fluorescent dyes. (23000848)
2013
11
Serum DNA hypermethylation in patients with kidney cancer: results of a prospective study. (24123044)
2013
12
Risk factors for non-melanoma skin cancer in kidney transplant patients in a Spanish population in the Mediterranean region. (23303600)
2013
13
Words of wisdom. Re: Long-term survival following partial vs radical nephrectomy among older patients with early-stage kidney cancer. (22748396)
2012
14
Re: Higher perioperative morbidity and in-hospital mortality in patients with end-stage renal disease undergoing nephrectomy for non-metastatic kidney cancer: a population-based analysis. (22784717)
2012
15
Targeting the mTOR pathway in Chromophobe Kidney Cancer. (22481981)
2012
16
Urinary acylcarnitines are altered in human kidney cancer. (21732340)
2012
17
Occupational trichloroethylene exposure and kidney cancer risk: a meta-analysis. (23000822)
2012
18
Kidney cancer: Metabolomics for targeted therapy. (22710669)
2012
19
Kidney cancer: First in vivo study shows optical imaging can distinguish renal cancer from normal tissue. (22641160)
2012
20
Kidney function following nephrectomy: similitude and discrepancies between kidney cancer and living donation. (20864365)
2012
21
Kidney cancer in 2010: drugs, surgery and survival in RCC. (21304541)
2011
22
New Frontiers in Imaging and Focal Therapy: Highlights From the Third International Symposium on Focal Therapy and Imaging of Prostate and Kidney Cancer, February 24-27, 2010, Washington, DC. (21935343)
2011
23
Basic research in kidney cancer. (21741760)
2011
24
Review: therapy for kidney cancer with a sarcomatoid component. (21326150)
2011
25
Familial clustering of sporadic kidney cancer: insufficient evidence to recommend routine screening in unaffected kin. (21741161)
2011
26
Inactivation of the von Hippel-Lindau tumor suppressor leads to selective expression of a human endogenous retrovirus in kidney cancer. (21602888)
2011
27
Cost analysis of two follow-up strategies for localized kidney cancer: a Canadian cohort comparison. (20944802)
2010
28
Trends from 1999 to 2007 in the surgical treatments of kidney cancer in Europe: data from the Veneto Region, Italy. (19818073)
2010
29
Kidney cancer: neoadjuvant targeted therapies in renal cell carcinoma. (20145660)
2010
30
Highlights from the Eigth International Kidney Cancer Symposium. (20332749)
2009
31
Ad5/3-9HIF-Delta24-VEGFR-1-Ig, an infectivity enhanced, dual-targeted and antiangiogenic oncolytic adenovirus for kidney cancer treatment. (19440223)
2009
32
Cytoreductive nephrectomy for kidney cancer with sarcomatoid histology--is up-front resection indicated and, if not, is it avoidable? (19758641)
2009
33
Kidney cancer: now available in a new flavor. (19061830)
2008
34
The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane. (17978814)
2008
35
Kidney cancer ablative therapy: indications and patient selection. (18366972)
2008
36
Tissue-based research in kidney cancer: current challenges and future directions. (18559586)
2008
37
Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance. (17300726)
2007
38
Dietary risk factors for kidney cancer in Eastern and Central Europe. (17456477)
2007
39
Kidney cancer: energy ablation. (17762624)
2007
40
Kidney cancer. (17509280)
2007
41
Understanding the natural biology of kidney cancer: implications for targeted cancer therapy. (17592537)
2007
42
New challenges in kidney cancer therapy: sunitinib. (17631600)
2007
43
Pathway analysis of kidney cancer using proteomics and metabolic profiling. (17123452)
2006
44
Allogeneic gene-modified tumour cells in metastatic kidney cancer. Report II. (15709712)
2004
45
Repeated cycles with 72-hour continuous infusion interleukin-2 in kidney cancer and melanoma. (15285881)
2004
46
Von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer. (14654728)
2004
47
Bibliography. Current world literature. Kidney, testis and penile cancer. (15202446)
2003
48
Mitochondrial targeting of human 8-oxoguanine DNA glycosylase hOGG1 is impaired by a somatic mutation found in kidney cancer. (12509224)
2002
49
Kidney cancer: the Cytokine Working Group experience (1986-2001): part II. Management of IL-2 toxicity and studies with other cytokines. (11917945)
2001
50
Health related quality of life outcomes in patients treated for metastatic kidney cancer: a pilot study. (9112487)
1997

Genetic Variations for Kidney Cancer

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Kidney Cancer:

62
id Symbol AA change Variation ID SNP ID
1FLCNp.Arg239CysVAR_066026rs78683075
2VHLp.Leu163ProVAR_034998rs28940297

Expression for genes affiliated with Kidney Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Kidney Cancer

Search GEO for disease gene expression data for Kidney Cancer.

Pathways for genes affiliated with Kidney Cancer

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Compounds for genes affiliated with Kidney Cancer

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44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Kidney Cancer according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1fumarate44 1111.8IL2, FH, VHL
2sunitinib44 49 1112.7VHL, IFNA1, IL2
3nnmt4410.7HNF1B, HNF1A
4fatty acid4410.7HNF1A, S100A7, FH, FABP1, PLIN2
5sorafenib44 49 1112.7IL2, IFNA1, VHL
6mizoribine4410.7IFNA1, IL2
7intron a4410.7IFNA1, IL2
8denileukin diftitox44 49 1112.6IFNA1, IL2
9phosphoenolpyruvate44 1111.6FABP1, FH, HNF1A
10pentostatin44 59 28 1113.5IL2, IFNA1
11glatiramer acetate44 1111.5IL2, IFNA1
12retinoic acid44 2411.5HNF1A, HNF1B, IFNA1, NDUFA13, S100A7, FABP1
13glucose4410.4FABP1, HNF1B, HNF1A
14rapamycin4410.2VHL, IFNA1, FLCN, IL2

GO Terms for genes affiliated with Kidney Cancer

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16Gene Ontology
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Biological processes related to Kidney Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of pronephros sizeGO:03556510.5HNF1B, HNF1A
2negative regulation of cell growthGO:03030810.5GDF9, FLCN, NDUFA13
3positive regulation of transcription initiation from RNA polymerase II promoterGO:06026110.4HNF1B, HNF1A
4regulation of Wnt receptor signaling pathwayGO:03011110.2HNF1B, HNF1A

Products for genes affiliated with Kidney Cancer

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Kidney Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet