MCID: KDN017
MIFTS: 66

Kidney Cancer malady

Nephrological diseases, Cancer diseases categories

Summaries for Kidney Cancer

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 You have two kidneys. they are fist-sized organs on either side of your backbone above your waist. the tubes inside filter and clean your blood, taking out waste products and making urine. kidney cancer forms in the lining of tiny tubes inside your kidneys. kidney cancer becomes more likely as you age. risk factors include smoking, having certain genetic conditions, and misusing pain medicines for a long time. you may have no symptoms at first. they may appear as the cancer grows. see your health care provider if you notice blood in your urine a lump in your abdomen weight loss for no reason pain in your side that does not go away loss of appetite treatment depends on your age, your overall health and how advanced the cancer is. it might include surgery, chemotherapy, or radiation, biologic, or targeted therapies. biologic therapy boosts your body's own ability to fight cancer. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Kidney Cancer, also known as renal cell carcinoma, is related to adenocarcinoma and prostate cancer. An important gene associated with Kidney Cancer is RNF139 (ring finger protein 139). The drugs medroxyprogesterone and medroxyprogesterone acetate and the compounds fumarate and sunitinib have been mentioned in the context of this disorder. Affiliated tissues include the kidney, kidney and prostate, and related mouse phenotype liver/biliary system.

Disease Ontology:8 A urinary system cancer that is located in the kidney.

Wikipedia:63 Kidney cancer is a type of cancer that starts in the cells in the kidney. more...

Description from OMIM:46 144700

Aliases & Classifications for Kidney Cancer

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Sources:
60UMLS, 8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 33MedlinePlus, 44Novoseek, 46OMIM, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

kidney cancer 8 42 10 33
renal cell carcinoma 46 10 60
renal cancer 8 42 44
renal cell carcinoma 1 42 60
malignant neoplasm of kidney except pelvis 8
conventional renal cell carcinoma 60
malignant neoplasm of kidney 60
malignant tumour of kidney 8
renal adenocarcinoma 42
carcinoma renal cell 44
renal cell cancer 42
hypernephroma 42


External Ids:

Disease Ontology8 DOID:263
NCIt39 C3150
MeSH34 D007680

Related Diseases for Kidney Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Kidney Cancer family:

Kidney Carcinoma in Situ Kidney Benign Neoplasm

Diseases related to Kidney Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 402)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.6HNF1B, VHL
2prostate cancer30.5HNF1B, FH, FABP1
3obesity30.3PLIN2, FABP1, HNF1A
4renal oncocytoma30.2FLCN
5cystic kidney30.2HNF1B, VHL, FH
6kidney rhabdoid cancer30.1VHL, IFNA1, FH, FLCN, IL2, PLIN2
7fumarate hydratase deficiency30.1FH
8leiomyomatosis30.0FH, VHL
9leiomyoma29.9FLCN, FH
10hepatitis29.8IFNA1
11colorectal cancer29.7HNF1A, IFNA1, FABP1, IL2, GSTM3
12adenoma29.7HNF1A, VHL, FABP1
13hepatocellular carcinoma29.7FABP1, IFNA1, HNF1B, HNF1A
14angiomyolipoma10.8
15bone carcinoma10.8
16small cell carcinoma10.7
17renal adenoma10.6
18parathyroid carcinoma10.6
19hemangioblastoma10.6
20adrenal carcinoma10.6
21nonpapillary renal cell carcinoma10.6
22large cell carcinoma10.5
23sarcoma10.5
24xanthogranulomatous pyelonephritis10.5
25glomerulonephritis10.5
26in situ carcinoma10.5
27pyelonephritis10.5
28multilocular clear cell renal cell carcinoma10.5
29hypercalcemia10.5
30papillary adenoma10.5
31mucinous tubular and spindle renal cell carcinoma10.5
32eosinophilic variant of chromophobe renal cell carcinoma10.5
33adrenocortical carcinoma10.5
34kidney disease10.5
35renal wilms' tumor10.4
36familial renal cell carcinoma10.4
37renal cell carcinoma10.4
38spindle cell carcinoma10.4
39metanephric adenoma10.4
40hereditary conventional renal cell carcinoma10.4
41polycystic kidney disease10.4
42autosomal dominant disease10.4
43kidney angiomyolipoma10.4
44papillary thyroid carcinoma10.4
45squamous cell carcinoma10.4
46polycystic kidney disease, autosomal dominant10.4
47renal cell carcinoma, papillary, 110.4
48cervicitis10.3
49meningioma10.3
50neuroblastoma10.3

Graphical network of the top 20 diseases related to Kidney Cancer:



Diseases related to kidney cancer

Clinical Features for Kidney Cancer

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Sources:
46OMIM
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Clinical features from OMIM:

144700

Drugs & Therapeutics for Kidney Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Kidney Cancer

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Anatomical Context for Kidney Cancer

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Kidney Cancer:

32
Kidney, Prostate, Lung, Skin, Breast, Endothelial, Colon, Testes, Liver, Heart, Bone, Eye, Ovary, Pancreas, T cells, Monocytes, Testis, Brain, Lymph node, Cortex

FMA organs/tissues related to Kidney Cancer:

14
The kidney

Animal Models for Kidney Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Kidney Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537010.5PLIN2, IL2, FABP1, VHL, HNF1B, HNF1A

Publications for Kidney Cancer

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Sources:
50PubMed
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Articles related to Kidney Cancer:

(show top 50)    (show all 605)
idTitleAuthorsYear
1
Kidney cancer: Temsirolimus fails to expand its role in patients with mRCC. (24346004)
2014
2
Kidney cancer. (22664338)
2013
3
Comparison of the viscoelastic properties of cells from different kidney cancer phenotypes measured with atomic force microscopy. (23324556)
2013
4
Kidney cancer: Stearoyl-CoA desaturase: a novel therapeutic target for RCC. (23689255)
2013
5
Occupational exposure to trichloroethylene and perchloroethylene and the risk of lymphoma, liver, and kidney cancer in four Nordic countries. (23447073)
2013
6
Short-Term and Long-Term Outcomes After Gastrectomy for Gastric Cancer in Patients With Chronic Kidney Disease. (24378553)
2013
7
Clinical features of kidney cancer in primary care: a case-control study using primary care records. (23540481)
2013
8
Cigarette Smoking and other Risk Factors for Kidney Cancer Death in a Japanese Population: Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC study). (24377561)
2013
9
Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects. (24158655)
2013
10
Reduced mRNA expression level of corticotropin-releasing hormone-binding protein is associated with aggressive human kidney cancer. (23607589)
2013
11
Aurora A overexpression and pVHL reduced expression are correlated with a bad kidney cancer prognosis. (23151618)
2012
12
Interleukin-15 plays a central role in human kidney physiology and cancer through the I^c signaling pathway. (22363690)
2012
13
Expression profiling based graph-clustering approach to determine renal carcinoma related pathway in response to kidney cancer. (22913210)
2012
14
Indocyanine green (ICG)-based fluorescence navigation system for discrimination of kidney cancer from normal parenchyma: application during partial nephrectomy. (22215306)
2012
15
Human apolipoprotein L1 (ApoL1) in cancer and chronic kidney disease. (22569246)
2012
16
Ascorbate antagonizes nickel ion to regulate JMJD1A expression in kidney cancer cells. (22318714)
2012
17
Fatty acid binding proteins (FABPs) in prostate, bladder and kidney cancer cell lines and the use of IL-FABP as survival predictor in patients with renal cell carcinoma. (21767383)
2011
18
Renal function outcomes after nephrectomy for kidney cancer in elderly patients. (22220418)
2011
19
Identification of MAPK10 as a novel epigenetic marker for chromophobe kidney cancer. (21166945)
2011
20
Impact of kidney cancer surgery on oncologic and kidney functional outcomes. (21956016)
2011
21
Genetic and functional studies implicate HIF1I+ as a 14q kidney cancer suppressor gene. (22037472)
2011
22
Management of locally recurrent kidney cancer. (20425632)
2010
23
Kidney Cancer Working Group report. (20870920)
2010
24
Elevated serum gamma-glutamyltransferase activity is associated with increased risk of mortality, incident type 2 diabetes, cardiovascular events, chronic kidney disease and cancer - a narrative review. (19943812)
2010
25
MicroRNAs: exploring a new dimension in the pathogenesis of kidney cancer. (20964839)
2010
26
Recent advances in focal therapy of prostate and kidney cancer. (20948877)
2010
27
New weapons against kidney cancer. Two recent drug options appear to extend survival for kidney cancer patients who can't tolerate existing medications. (20148481)
2010
28
The therapy of kidney cancer with biomolecular drugs. (21129605)
2010
29
Body mass index and subsequent risk of kidney cancer: a prospective cohort study in Japan. (20470974)
2010
30
Kidney cancer: the new landscape. (19188766)
2009
31
Does immunotherapy still have a role in treating kidney cancer? (19833066)
2009
32
Phosphatidylinositol-3-kinase/Akt signaling pathway and kidney cancer, and the therapeutic potential of phosphatidylinositol-3-kinase/Akt inhibitors. (19836781)
2009
33
A Generalized Beta model for the age distribution of cancers: application to pancreatic and kidney cancer. (19718452)
2009
34
Sorafenib tosylate in advanced kidney cancer: past, present and future. (19436197)
2009
35
Low-dose cyclophosphamide and continuous-infusion interleukin-2 with famotidine in previously treated metastatic melanoma or kidney cancer. (18298334)
2008
36
Prospective comparison of sorafenib and sunitinib for second-line treatment of cytokine-refractory kidney cancer patients. (18714170)
2008
37
Temsirolimus: new drug. Metastatic kidney cancer: more assessment needed. (19415885)
2008
38
Advances in diagnosis and follow-up in kidney cancer. (18670266)
2008
39
No evidence for advanced glycation endproducts in cancer. Comment on SebekovA! et al: genomic damage and malignancy in end-stage renal failure: do advanced glycation end products contribute? (Kidney Blood Press Res 2007;30:56-66). (17700031)
2007
40
Reproductive characteristics and risk of kidney cancer: Iowa Women's Health Study. (17822863)
2007
41
Designing clinical trials for kidney cancer based on newly developed prognostic and predictive tools. (16480663)
2006
42
Time trend and age-period-cohort effect on kidney cancer mortality in Europe, 1981-2000. (16672041)
2006
43
Identification of protein pattern in kidney cancer using ProteinChip arrays and bioinformatics. (15647845)
2005
44
Novel agents for the treatment of advanced kidney cancer. (16163253)
2004
45
Reduction in kidney cancer mortality following installation of a tap water supply system in an arsenic-endemic area of Taiwan. (16381491)
2004
46
Kidney cancer: the Cytokine Working Group experience (1986-2001): part I. IL-2-based clinical trials. (11917944)
2001
47
Molecular genetics of kidney cancer: implications for the physician. (16389344)
2000
48
Expression of the plasminogen activation system in kidney cancer correlates with its aggressive phenotype. (9563880)
1998
49
The role of immunotherapy in metastatic cancer of the kidney]. (7730669)
1994
50
Renal cancer complicating acquired cystic kidney disease. (7894008)
1994

Genetic Variations for Kidney Cancer

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Kidney Cancer:

62
id Symbol AA change Variation ID SNP ID
1FLCNp.Arg239CysVAR_066026rs78683075
2VHLp.Leu163ProVAR_034998rs28940297

Expression for genes affiliated with Kidney Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Kidney Cancer

Search GEO for disease gene expression data for Kidney Cancer.

Pathways for genes affiliated with Kidney Cancer

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Compounds for genes affiliated with Kidney Cancer

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Kidney Cancer according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1fumarate44 1111.8IL2, FH, VHL
2sunitinib44 49 1112.7VHL, IFNA1, IL2
3nnmt4410.7HNF1B, HNF1A
4fatty acid4410.7S100A7, FH, FABP1, PLIN2, HNF1A
5sorafenib44 49 1112.7VHL, IFNA1, IL2
6intron a4410.7IFNA1, IL2
7mizoribine4410.7IL2, IFNA1
8denileukin diftitox44 49 1112.6IL2, IFNA1
9phosphoenolpyruvate44 1111.6HNF1A, FH, FABP1
10pentostatin44 59 28 1113.5IFNA1, IL2
11glatiramer acetate44 1111.5IFNA1, IL2
12retinoic acid44 2411.5S100A7, NDUFA13, IFNA1, HNF1A, FABP1, HNF1B
13glucose4410.4FABP1, HNF1B, HNF1A
14rapamycin4410.2FLCN, IFNA1, IL2, VHL

GO Terms for genes affiliated with Kidney Cancer

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16Gene Ontology
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Biological processes related to Kidney Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of pronephros sizeGO:03556510.5HNF1B, HNF1A
2negative regulation of cell growthGO:03030810.5GDF9, FLCN, NDUFA13
3positive regulation of transcription initiation from RNA polymerase II promoterGO:06026110.4HNF1B, HNF1A
4regulation of Wnt receptor signaling pathwayGO:03011110.2HNF1B, HNF1A

Products for genes affiliated with Kidney Cancer

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  • Antibodies
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  • Antibodies

Sources for Kidney Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet