MCID: KDN018
MIFTS: 58

Kidney Disease malady

Summaries for Kidney Disease

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32MalaCards
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MalaCards: Kidney Disease, also known as kidney diseases, is related to polycystic kidney disease and polycystic kidney disease, autosomal dominant. An important gene associated with Kidney Disease is PKD2 (polycystic kidney disease 2 (autosomal dominant)). The drugs dopamine and dopamine hydrochloride and the compounds trp-p-2 and la3+ have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and bone, and related mouse phenotype renal/urinary system.

Aliases & Classifications for Kidney Disease

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8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

kidney disease 8
kidney diseases 60


External Ids:

Disease Ontology8 DOID:557
MeSH34 D007674

Related Diseases for Kidney Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Chronic Kidney Failure family:

Acute Kidney Failure kidney disease
Renal Infectious Disease Ren-Related Kidney Disease
Renal Dysplasia

Diseases related to Kidney Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 435)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic kidney disease31.9PKD1, PKHD1
2polycystic kidney disease, autosomal dominant31.7PKD1, PKD2
3cystic kidney31.4PKD2, PKHD1, UMOD, PKD1
4polycystic kidney disease, autosomal recessive31.2IFT88, PKHD1, PKD2, PKD1
5nephronophthisis30.8PKD1, PKD2, UMOD
6aneurysm disease30.7PKD1, PKD2
7polycystic liver disease30.7PKHD1, PKD2, PKD1, PKD1P6
8congenital hepatic fibrosis30.7PKHD1
9uromodulin-associated kidney disease30.6MCKD2, UMOD
10umod-associated kidney disease30.5MCKD2, UMOD
11polycystic kidney disease, type 230.5PKD1, PKD2
12tuberous sclerosis30.5PKHD1, PKD1, PKD1P6
13primary hyperoxaluria30.2UMOD, PKHD1, PKD2, PKD1
14glomerulocystic kidney disease with hyperuricemia and isosthenuria30.1MCKD2, UMOD
15autosomal dominant disease11.2
16autosomal recessive disease10.8
17hypertension10.8
18proteinuria10.7
19vascular disease10.7
20hepatitis10.6
21chronic kidney failure10.6
22liver disease10.6
23hyperparathyroidism10.5
24medullary cystic kidney disease type 110.5
25autosomal genetic disease10.5
26diabetes mellitus10.5
27chromosomal disease10.5
28obesity10.5
29renal cell carcinoma10.5
30kidney cancer10.5
31hyperphosphatemia10.5
32hyperuricemia10.4
33aortic disease10.4
34peritonitis10.4
35hepatitis a10.4
36kidney hypertrophy10.4
37atherosclerosis10.4
38renal hypertension10.4
39end stage renal failure10.4
40metabolic acidosis10.4
41brain disease10.3
42coronary artery disease10.3
43periodontal disease10.3
44periodontitis10.3
45gout10.3
46renal osteodystrophy10.3
47glomerulonephritis10.3
48type 2 diabetes mellitus10.3
49deficiency anemia10.3
50hepatitis c10.3

Graphical network of the top 20 diseases related to Kidney Disease:



Diseases related to kidney disease

Clinical Features for Kidney Disease

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Drugs & Therapeutics for Kidney Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Kidney Disease

Drug clinical trials:

Search ClinicalTrials for Kidney Disease

Search NIH Clinical Center for Kidney Disease

Search CenterWatch for Kidney Disease

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Kidney Disease

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Anatomical Context for Kidney Disease

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32MalaCards
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MalaCards organs/tissues related to Kidney Disease:

32
Kidney, Liver, Bone, Heart, Endothelial, Brain, Monocytes, Testes, Skin, Lung, Pancreas, Thyroid, Pituitary, Skeletal muscle, Bone marrow, Prostate, Spinal cord, T cells, Appendix, Colon, Eye, Spleen, Myeloid, Pineal

Animal Models for Kidney Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Kidney Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536711.4PKD1, PKD2, PKHD1, PKD1L1, UMOD, IFT88

Publications for Kidney Disease

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50PubMed
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Articles related to Kidney Disease:

(show top 50)    (show all 3349)
idTitleAuthorsYear
1
L-Carnitine supplementation for adults with end-stage kidney disease requiring maintenance hemodialysis: a systematic review and meta-analysis. (24368434)
2014
2
Changing referral characteristics of patients with autosomal dominant polycystic kidney disease. (23830538)
2013
3
Growth Retardation in Children with Kidney Disease. (24187550)
2013
4
Association of insulin resistance with chronic kidney disease in non-diabetic subjects with normal weight. (24058515)
2013
5
Kidney and urinary tract involvement in kawasaki disease. (24288547)
2013
6
Thyroid hormone replacement therapy attenuates the decline of renal function in chronic kidney disease patients with subclinical hypothyroidism. (23281965)
2013
7
The Oxford Renal (OxRen) cross-sectional study of chronic kidney disease in the UK. (24345903)
2013
8
Short-term renal hemodynamic effects of tolvaptan in subjects with autosomal dominant polycystic kidney disease at various stages of chronic kidney disease. (23903369)
2013
9
The AGE-RAGE Pathway and Its Relation to Cardiovascular Disease in Patients with Chronic Kidney Disease. (24231387)
2013
10
Elevated serum bone morphogenetic protein 4 in patients with chronic kidney disease and coronary artery disease. (23208015)
2013
11
Polycystin-1C terminus cleavage and its relation with polycystin-2, two proteins involved in polycystic kidney disease. (23570767)
2013
12
Sturge-Weber syndrome coexisting with autosomal dominant polycystic kidney disease. (22828742)
2013
13
Successful conservative treatment of bilateral emphysematous pyelonephritis in autosomal dominant polycystic kidney disease. (23814427)
2013
14
Churg-Strauss syndrome with a clinical condition similar to IgG4-related kidney disease: a case report. (22687796)
2012
15
Two non-invasive GFR-estimation methods in rat models of polycystic kidney disease: 3.0 Tesla dynamic contrast-enhanced MRI and optical imaging. (21444361)
2011
16
Macrophages promote cyst growth in polycystic kidney disease. (21921140)
2011
17
Polycystic kidney disease-like domains of clostridial collagenases and their role in collagen recruitment. (21871007)
2011
18
Autosomal dominant polycystic kidney disease: genetics, mutations and microRNAs. (21392578)
2011
19
Comparative study of quantitative ultrasonography and dual-energy X-ray absorptiometry for evaluating renal osteodystrophy in children with chronic kidney disease. (20845051)
2011
20
Genetic variation at selected SNPs in the leptin gene and association of alleles with markers of kidney disease in a Xhosa population of South Africa. (20140086)
2010
21
Neutrophil gelatinase-associated lipocalin is a new and sensitive marker of kidney function in chronic kidney disease patients and renal allograft recipients. (19249502)
2009
22
Associations of resting heart rate with insulin resistance, cardiovascular events and mortality in chronic kidney disease. (19307229)
2009
23
Immunoregulatory role of TNFalpha in inflammatory kidney diseases. (19436333)
2009
24
Is there a role for direct renin inhibitors in chronic kidney disease? (19584722)
2009
25
Drug discovery for overcoming chronic kidney disease (CKD): pharmacological effects of mineralocorticoid-receptor blockers. (19151533)
2009
26
Kidney function estimated from serum creatinine and cystatin C and peripheral arterial disease in NHANES 1999-2002. (19487236)
2009
27
Peroxisome proliferator-activated receptor gamma agonists in kidney disease--future promise, present fears. (19546582)
2009
28
Vascular calcification: the killer of patients with chronic kidney disease. (19478096)
2009
29
Bone markers predict cardiovascular events in chronic kidney disease. (18597636)
2008
30
Cessation of galactorrhea in a chronic kidney disease patient with non-tumoral hyperprolactinemia after renal transplantation. (18472504)
2008
31
Isoforms of retinol binding protein 4 (RBP4) are increased in chronic diseases of the kidney but not of the liver. (18752671)
2008
32
The role of obesity and its bioclinical correlates in the progression of chronic kidney disease. (17045221)
2006
33
Association of kidney function with mortality in patients with chronic kidney disease not yet on dialysis: a historical prospective cohort study. (16580621)
2006
34
The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. (16567633)
2006
35
Beta blockers in the management of chronic kidney disease. (17021610)
2006
36
Molecular pathogenesis of autosomal dominant polycystic kidney disease. (16515728)
2006
37
Antihypertensive agents for preventing diabetic kidney disease. (16235351)
2005
38
Pathophysiology of vascular calcification in chronic kidney disease. (15375022)
2004
39
Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney disease. (15509540)
2004
40
The ENOS polymorphism is not associated with severity of renal disease in polycystic kidney disease 1. (12500225)
2003
41
Transforming growth factor-beta(1) in the kidney and urine of patients with glomerular disease and proteinuria. (12454225)
2002
42
The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein. (11919560)
2002
43
Von Hippel-Lindau disease masquerading as autosomal dominant polycystic kidney disease. (11273887)
2001
44
Flaxseed ameliorates interstitial nephritis in rat polycystic kidney disease. (9987066)
1999
45
Effect of kidney function and disease status on urinary tissue factor measurements. (9659267)
1998
46
Immunological aspects of circulating immune complexes in kidney diseases in patients with chronic alcoholism]. (10067256)
1998
47
Expression of the intercellular adhesion molecule-3 (ICAM-3) in human renal tissue with relation to kidney transplants and various inflammatory diseases. (7576578)
1995
48
Immunoreactivity of S100 beta in heart, skeletal muscle, and kidney in chronic lung disease: possible induction by cAMP. (1664955)
1991
49
Beta-N-acetylglucosaminidase (beta-NAG) as a parameter in the diagnosis and evaluation of primary glomerular and tubulointerstitial kidney diseases]. (1962476)
1991
50
Renal tuberculosis simulating polycystic kidney disease angiographically. (4836341)
1974

Genetic Variations for Kidney Disease

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Expression for genes affiliated with Kidney Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Kidney Disease

Search GEO for disease gene expression data for Kidney Disease.

Pathways for genes affiliated with Kidney Disease

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Compounds for genes affiliated with Kidney Disease

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44Novoseek, 28IUPHAR
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Compounds related to Kidney Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1trp-p-24410.8PKD1, PKD2
2la3+2810.8PKD2, PKD2L1
3cai2+2810.7PKD2, PKD2L1
4gd3+2810.5PKD2, PKD2L1

GO Terms for genes affiliated with Kidney Disease

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16Gene Ontology
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Cellular components related to Kidney Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ciliumGO:00592911.2PKD1, PKD2, PKD1L1, IFT88
2motile primary ciliumGO:03151211.1PKD1, PKD2, IFT88
3microtubule basal bodyGO:00593210.9PKD2, PKHD1, IFT88
4polycystin complexGO:00213310.8PKD2, PKD1
5primary ciliumGO:07237210.8PKHD1, UMOD
6mitotic spindleGO:07268610.5PKD2, PKHD1

Biological processes related to Kidney Disease according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1detection of mechanical stimulusGO:05098211.8PKD2, PKD1L1, PKD1, PKDREJ, PKD2L2, PKD2L1
2calcium ion transmembrane transportGO:07058811.8PKD2L2, PKD1, PKD2, PKD2L1, PKD1L1, PKDREJ
3neuropeptide signaling pathwayGO:00721811.4PKD1L3, PKD1L2, PKD1, PKDREJ
4metanephric ascending thin limb developmentGO:07221811.3UMOD, PKD1, PKD2
5detection of nodal flowGO:00312711.1PKD1L1, PKD2
6detection of chemical stimulus involved in sensory perception of sour tasteGO:00158111.1PKD2L1, PKD1L3
7mesonephric tubule developmentGO:07216411.1PKD1, PKD2
8mesonephric duct developmentGO:07217711.0PKD2, PKD1
9cellular response to acidityGO:07146811.0PKD2L1, PKD1L3
10positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycGO:03165911.0PKD1, PKD2
11placenta blood vessel developmentGO:06067411.0PKD2, PKD1
12cytoplasmic sequestering of transcription factorGO:04299410.9PKD2, PKD1
13sodium ion transmembrane transportGO:03572510.9PKD2L1, PKD2
14spinal cord developmentGO:02151010.9PKD2, PKD1
15cation transportGO:00681210.8PKD2L1, PKD1L3
16JAK-STAT cascadeGO:00725910.8PKD1, PKD2
17neural tube developmentGO:02191510.7PKD1, PKD2
18embryonic placenta developmentGO:00189210.5PKD1, PKD2

Molecular functions related to Kidney Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium channel activityGO:00526211.4PKD1, PKD1L1, PKD2L1, PKD2L2, PKDREJ
2calcium ion bindingGO:00550911.3PKDREJ, PKD2L2, PKD2, UMOD, PKD1L2, PKD2L1
3cation channel activityGO:00526111.0PKD1, PKD1L3, PKD2L1
4carbohydrate bindingGO:03024611.0PKD1, PKD1L2, PKD1L3
5sour taste receptor activityGO:03304010.8PKD2L1, PKD1L3
6cation transmembrane transporter activityGO:00832410.5PKD2L1, PKD1L3

Products for genes affiliated with Kidney Disease

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Sources for Kidney Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet