Kidney Disease malady

MalaCards: Kidney Disease, also known as kidney diseases, is related to carcinoma and pancreatitis. An important gene associated with Kidney Disease is PKD1 (polycystic kidney disease 1 (autosomal dominant)), and among its related pathways are Molecular Mechanisms of Cancer and Pathways in cancer. The drugs albumin,human and dopamine and the compounds arachidonic acid and vitamin d have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and heart, and related mouse phenotypes are growth/size and mortality/aging.

Aliases & Descriptions:

kidney disease 6 kidney diseases 43

Diseases related to kidney disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1008)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	66.4	PIK3C2A, LRP1, LRP2, KL, REN, RET
2	pancreatitis	54.8	PIK3C2A, LRP1, LRP2, LRP8, KL, REN
3	nephropathy	53.2	LRP1, LRP2, REN, RETN, CNDP1, VWF
4	prostatitis	52.8	PIK3C2A, LRP1, LRP2, KL, RET, RETN
5	fibrosis	51.5	LRP1, KL, REN, RETN, CNR1, CNR2
6	diabetes mellitus	49.8	PIK3C2A, REN, RET, RETN, CNDP1, CNR1
7	atherosclerosis	49.6	PIK3C2A, LRP1, LRP2, LRP8, KL, REN
8	insulin resistance	49.5	LRP1, REN, RETN, CNR1, VWF, PCSK1
9	obesity	48.1	PIK3C2A, LRP1, REN, RETN, CNR1, CNR2
10	thyroiditis	47.8	PIK3C2A, LRP1, LRP2, LRRC6, REN, RET
11	polycystic kidney disease	47.3	PCSK2, BRAF, VHL, CLU, PAX2, UMOD
12	retinitis	47.2	PIK3C2A, LRP1, LRP2, CNR1, CNR2, KIF3A
13	cholesterol	46.8	PIK3C2A, LRP1, LRP2, LRP8, KL, REN
14	hypoxia	44.6	PIK3C2A, LRP1, REN, RET, VWF, SELE
15	arthritis	44.4	LRP1, LRP2, KL, RETN, CNR1, CNR2
16	proteinuria	42.8	PIK3C2A, LRP2, REN, VWF, RBP4, SERPINC1
17	ischemia	42.5	PIK3C2A, REN, RETN, CNR1, CNR2, VWF
18	myocardial infarction	42.2	PIK3C2A, LRP1, LRP8, REN, RETN, CNR1
19	aldosteronism	42.0	KL, REN, RETN, SERPINE1, NAGLU, NAMPT
20	anemia	41.9	REN, VWF, GCLM, SELE, SERPINC1, NAGLU
21	rheumatoid arthritis	41.9	LRP1, LRP2, KL, RETN, CNR1, CNR2
22	type 2 diabetes mellitus	40.4	PIK3C2A, REN, RETN, CNR1, CNR2, VWF
23	peritonitis	39.9	PIK3C2A, LRP1, REN, RET, VWF, RBP4
24	polycystic kidney disease, autosomal dominant	39.8	REN, PCSK2, PCSK1, BRAF, MYC, RAF1
25	cystic fibrosis	39.7	REN, VWF, RBP4, SERPINC1, NAGA, NAGLU
26	hyperparathyroidism	39.4	LRP2, KL, RET, VWF, SELE, SERPINE1
27	cystic kidney	38.5	BCAR1, UMOD, INVS, HNF1B, PKD1, PKD2
28	homocysteine	38.3	PIK3C2A, REN, RETN, VWF, GCK, SETDB1
29	myeloma	38.3	LRP1, LRP2, KIF11, VWF, SFRP4, GCLM
30	hyperglycemia	38.1	PIK3C2A, RETN, CNDP1, CNR1, VWF, PCK1
31	primary hyperoxaluria	37.8	PIK3C2A, LRP2, VWF, LPL, UTS2, BGLAP
32	lupus erythematosus	37.7	PIK3C2A, LRP2, RETN, VWF, RBP4, SELE
33	tuberous sclerosis	37.4	VIM, VHL, VEGFA, MYC, MTOR, MMP2
34	nephritis	36.9	LRP2, REN, VWF, RBP4, SELE, SERPINB7
35	end stage renal failure	36.9	RETN, CNDP1, VEGFA, BGLAP, BDKRB1, UMOD
36	polycystic kidney disease, autosomal recessive	36.7	PIK3C2A, LGALS3, AVPR2, IFT88, CAMP, HNF1A
37	hypertension	36.6	REN, KCNMB1, GNB3, NOS2, NOS3, ACE
38	coronary heart disease	36.3	PIK3C2A, LRP1, RETN, CNDP1, VWF, PCSK9
39	glomerulonephritis	36.2	LRP1, LRP2, REN, VWF, RBP4, SERPINC1
40	multiple myeloma	35.8	LRP1, KIF11, VWF, SFRP4, RBP4, SERPINC1
41	renal cell carcinoma	35.8	RET, VIM, BRAF, VHL, VEGFA, BMP7
42	nephronophthisis	35.5	UMOD, MTOR, XPNPEP3, INVS, GLIS2, TMEM67
43	blindness	34.9	PIK3C2A, REN, CNR1, VWF, RBP4, SELE
44	nephrotic syndrome	34.8	PIK3C2A, LRP2, REN, RETN, VWF, RBP4
45	chronic kidney failure	34.7	REN, LPL, VDR, LEP, B2M, CD79A
46	alport syndrome	34.4	BMP6, LAMA5, LAMB1, CD79A, ITGA2, MMP3
47	thrombosis	34.2	PIK3C2A, LRP1, REN, RETN, VWF, SELE
48	aortic aneurysm	34.2	PIK3C2A, REN, RETN, VWF, SELE, SERPINC1
49	hyperlipidemia	34.2	PIK3C2A, LRP1, RETN, VWF, PCSK9, GCK
50	retinol binding protein	33.9	RETN, RBP4, VIM, NAGLU, NAMPT, LPA

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 albumin,human, albumin,human inj [va product], dopamine, dopamine hydrochloride

MalaCards organs/tissues related to kidney disease:

²²

MGI Mouse Phenotypes related to kidney disease:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size phenotype	MP:0005378	INF	PIK3C2A, LRP1, LRP2, LRP8, KL, REN
2	mortality/aging	MP:0010768	INF	PIK3C2A, LRP1, LRP8, KL, REN, RET
3	cellular phenotype	MP:0005384	INF	LRP2, LRP8, KL, RET, CNR1, KIF3A
4	cardiovascular system phenotype	MP:0005385	INF	LRP1, KL, REN, RET, KIF3A, VWF
5	liver/biliary system phenotype	MP:0005370	INF	RETN, PCSK9, PCK1, GCK, SERPINC1, VHL
6	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3C2A, LRP1, LRP2, KL, REN, RET
7	renal/urinary system phenotype	MP:0005367	23.7	LRP2, KL, REN, RET, KIF3A, SFRP4
8	digestive/alimentary phenotype	MP:0005381	19.9	LRP2, KL, RET, KIF3A, VWF, SFRP4
9	skeleton phenotype	MP:0005390	19.6	LRP1, LRP2, CNR1, KIF3A, NAGLU, BRAF
10	normal phenotype	MP:0002873	17.7	LRP1, LRP8, REN, RET, PCK1, RBP4
11	vision/eye phenotype	MP:0005391	16.1	LRP2, KIF3A, RBP4, SELE, SERPINC1, VIM
12	adipose tissue phenotype	MP:0005375	15.6	PIK3C2A, LRP1, KL, RETN, CNR1, PCSK1
13	craniofacial phenotype	MP:0005382	15.3	LRP2, KIF3A, NAGLU, LMX1B, BAMBI, LAMA3
14	limbs/digits/tail phenotype	MP:0005371	14.6	KL, RET, KIF3A, VHL, VEGFA, VDR
15	hearing/vestibular/ear phenotype	MP:0005377	14.1	LRP2, NAGLU, VDR, MYC, BMP7, RARA
16	respiratory system phenotype	MP:0005388	14.1	LRP2, KL, RET, KIF3A, SFRP4, LPL
17	no phenotypic analysis	MP:0003012	13.2	LRP2, RET, CNR1, PCK1, VEGFA, VCAM1
18	endocrine/exocrine gland phenotype	MP:0005379	13.0	PIP5K1B, LRP2, KL, RET, PCSK2, PCSK1
19	nervous system phenotype	MP:0003631	INF	LRP1, LRP8, KL, REN, CNR1, VWF
20	integument phenotype	MP:0010771	INF	KL, CNR1, CNR2, PCSK2, PCK1, BRAF
21	embryogenesis phenotype	MP:0005380	INF	RET, KIF3A, KIF11, SETDB1, SERPINC1, VIM
22	muscle phenotype	MP:0005369	INF	LRP1, KL, REN, RET, PCSK1, RBP4
23	immune system phenotype	MP:0005387	INF	PIP5K1B, LRP1, KL, REN, CNR2, VWF
24	reproductive system phenotype	MP:0005389	INF	PIP5K1B, LRP8, REN, RET, KIF11, SFRP4
25	hematopoietic system phenotype	MP:0005397	INF	PIP5K1B, PCSK1, BRAF, VHL, VAMP8, MZF1
26	behavior/neurological phenotype	MP:0005386	INF	LRP1, LRP2, LRP8, KL, REN, CNR1
27	other phenotype	MP:0005395	INF	KL, CNR1, RARA, CLU, LDLR, LAMA4
28	tumorigenesis	MP:0002006	INF	RET, SERPINE1, BRAF, VHL, MZF1, MYC
29	pigmentation phenotype	MP:0001186	INF	SERPINC1, NAGLU, BRAF, MYC, BMP7, PAX2

Articles related to kidney disease:

(show top 50)    (show all 1269)

id	Title	Authors	Year	Affiliating Genes
1	Vitamin D receptor activation and left ventricular hy pertrophy in advanced kidney disease. (21242674)	Thadhani R.... Solomon S.D.	2011	VDR
2	Endothelin, hypertension and chronic kidney disease: new insights. (20051851)	Kohan D.E.	2010	EDN1
3	Comparative effects of benidipine and amlodipine on p roteinuria, urinary 8-OHdG, urinary L-FABP, and inflammatory and atherosclerosi s markers in early-stage chronic kidney disease. (20145433)	Nakamura T.... Koide H.	2010	IL6, HMGB1
4	Circulating levels of osteopontin are closely related to glomerular filtration rate and cardiovascular risk markers in patients with chronic kidney disease. (20486990)	Lorenzen J.... Kielstein J.T.	2010	SPP1
5	MAP/ERK kinase kinase 1 (MEKK1) mediates transcriptio nal repression by interacting with polycystic kidney disease-1 (PKD1) promoter- bound p53 tumor suppressor protein. (20923779)	Islam M.R.... Calvet J.P.	2010	TP53, PKD1, MAP3K1
6	Novel method for genomic analysis of PKD1 and PKD2 mutations in autosomal dominant polycystic kidney disease. (18837007)	Tan Y.-C.... Rennert H.	2009	PKD1, PKD2
7	Calcimimetics in the chronic kidney disease-mineral and bone disorder. (19363783)	Bover J.... Ballarin J.	2009	CASR
8	Evidence for pathogenicity of atypical splice mutatio ns in autosomal dominant polycystic kidney disease. (19158373)	Wang K.... Pei Y.	2009	PKD1, PKD2
9	High prevalence of vitamin D deficiency in north Indi an adults is exacerbated in those with chronic kidney disease. (19207865)	Jabbar Z.... Jha V.	2009	ALB
10	Interaction of aldosterone and extracellular volume i n the pathogenesis of obesity-associated kidney disease: a narrative review. (19299892)	Bomback A.S.... Klemmer P.J.	2009	NR3C2
11	Managing anaemia in kidney transplant patients with chronic kidney disease (19675658)	LA^pez Oliva M.O.... FernA!ndez Fresnedo G.	2009	EPO
12	Selenium supplementation to chronic kidney disease patients on hemodialysis does not induce the synthesis of plasma glutathione peroxidase. (19238255)	Zachara B.A.... Sobala W.	2009	GPX3
13	Correlates of N-terminal prohormone brain natriuretic peptides in African Americans with hypertensive chronic kidney disease: the African American Study of Kidney Disease and Hypertension. (18824845)	Yi S.... Astor B.C.	2009	NPPB
14	Mouse models of polycystic kidney disease. (19186247)	Wilson P.D.	2008	PKD1, PKD2, PKHD1
15	N-terminal prohormone brain natriuretic peptide as a predictor of cardiovascular disease and mortality in blacks with hypertensive kidney disease: the African American Study of Kidney Disease and Hypertension (AASK). (18362234)	Astor B.C.... Contreras G.	2008	NPPB
16	Modifier effect of the Glu298Asp polymorphism of endothelial nitric oxide synthase gene in autosomal-dominant polycystic kidney disease. (18815450)	Stefanakis N.... Lamnissou K.	2008	NOS3
17	Risk factors for development and progression of diabetic kidney disease and treatment patterns among diabetic siblings of patients with diabetic kidney disease. (18155530)	Bleyer A.J.... Schelling J.R.	2008	ALB
18	Recombinant human Epo treatment: beneficial in chronic kidney disease, chronic heart failure, or both? Editorial to: 'Correction of anemia with erythropoietin in chronic kidney disease (stage 3 or 4): effects on cardiac performance by Pappas et al.'. (18219567)	Belonje A.M.... Voors A.A.	2008	EPO
19	Vitamin D and outcomes in chronic kidney disease. (17293681)	Cheng S.... Coyne D.	2007	VDR
20	Endothelin B receptor blockade accelerates disease progression in a murine model of autosomal dominant polycystic kidney disease. (17202412)	Chang M.Y.... Ong A.C.	2007	EDNRB, EDNRA, EDN1
21	B-type natriuretic peptide concentrations predict the progression of nondiabetic chronic kidney disease: the Mild-to-Moderate Kidney Disease Study. (17478561)	Spanaus K.S.... von Eckardstein A.	2007	NPPB
22	TRP channels and kidney disease: lessons from polycystic kidney disease. (17233617)	Qamar S.... Sandford R.	2007	PKD2
23	PKDB: Polycystic Kidney Disease Mutation Database--a gene variant database for autosomal dominant polycystic kidney disease. (17370309)	Gout A.M.... Ravine D.	2007	PKD1, PKD2
24	Fibroblast growth factor 23 (FGF23) predicts progression of chronic kidney disease: the Mild to Moderate Kidney Disease (MMKD) Study. (17656479)	Fliser D.... Riegler P.	2007	FGF23
25	Gender-specific association of adiponectin as a predictor of progression of chronic kidney disease: the Mild to Moderate Kidney Disease Study. (17457380)	Kollerits B.... Kronenberg F.	2007	ADIPOQ
26	Serum NTX is a practical marker for assessing antires orptive therapy for glucocorticoid treated patients with chronic kidney disease . (16781904)	Hamano T.... Ito T.	2006	PAX5
27	Obesity and insulin resistance as risk factors for chronic kidney disease. (17679819)	Whaley-Connell A.... Bakris G.L.	2006	INS
28	Correlation and prognostic utility of B-type natriuretic peptide and its amino-terminal fragment in patients with chronic kidney disease. (16938661)	Austin W.J.... Fitzgerald R.L.	2006	NPPB
29	Apolipoprotein A-IV predicts progression of chronic kidney disease: the mild to moderate kidney disease study. (16382017)	Boes E.... Kronenberg F.	2006	APOE, APOA4
30	Sodium ferric gluconate causes oxidative stress but not acute renal injury in patients with chronic kidney disease: a pilot study. (15522899)	Leehey D.J.... Agarwal R.	2005	TF
31	Renal insulin resistance syndrome, adiponectin and cardiovascular events in patients with kidney disease: the mild and moderate kidney disease study. (15743998)	Becker B.... Fliser D.	2005	ADIPOQ, INS
32	Molecular mechanisms activating muscle protein degradation in chronic kidney disease and other catabolic conditions. (15733069)	Du J.... Mitch W.E.	2005	CASP3
33	An evolutionarily conserved coiled-coil protein impli cated in polycystic kidney disease is involved in basal body duplication and fl agellar biogenesis in Trypanosoma brucei. (15831481)	Morgan G.W.... Field M.C.	2005	LRRC6
34	A novel pattern of mutation in uromodulin disorders: autosomal dominant medullary cystic kidney disease type 2, familial juvenile hyperuricemic nephropathy, and autosomal dominant glomerulocystic kidney disease. (15983957)	Lens X.M.... Barrio-Lucia V.	2005	UMOD
35	Gene diagnosis of autosomal dominant polycystic kidney disease type 2 using microsatellite DNA tightly linked to polycystic kidney disease gene 2 (15300626)	Zhang W.L.... Mei C.L.	2004	PKD2
36	Preimplantation genetic diagnosis for polycystic kidney disease. (15482771)	Verlinsky Y.... Kuliev A.	2004	PKD1, PRKD2
37	Insulin resistance in kidney disease patients with mild to moderate kidney disease. (15777067)	Stefikova K.... Dzurik R.	2004	INS
38	Validation of the Kidney Disease Quality of Life (KDQOL) cognitive function subscale. (15569327)	Kurella M.... Chertow G.M.	2004	ALB
39	Sexual dysfunction in men and women with chronic kidney disease and end-stage kidney disease. (12616463)	Palmer B.F.	2003	EPO
40	Multiorgan mRNA misexpression in murine autosomal rec essive polycystic kidney disease. (12371956)	Gattone V.H.... Klein R.M.	2002	PKD1
41	Microarray studies of gene expression in circulating leukocytes in kidney diseases. (11937761)	Alcorta D.... Falk R.	2002	CD79A
42	Angiotensin-converting enzyme activity and the ACE Alu polymorphism in autosomal dominant polycystic kidney disease. (11733623)	Schiavello T.... Thomas M.	2001	ACE
43	The ACE insertion/deletion polymorphism has no influence on progression of renal function loss in autosomal dominant polycystic kidney disease. (10831637)	van Dijk M.A.... Chang P.C.	2000	ACE
44	Screening the 3' region of the polycystic kidney disease 1 (PKD1) gene reveals six novel mutations. (8554072)	Peral B.... Harris P.C.	1996	PKD1
45	Epidermal growth factor ameliorates autosomal recessive polycystic kidney disease in mice. (7781894)	Gattone V.H.... Cowley B.D.	1995	EGF, ALB
46	Insulin resistance in kidney diseases (7725638)	SpustovA! V.... DzA_rik R.	1995	INS
47	The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16. The European Polycystic Kidney Disease Consortium. (8069919)		1994	PKD1
48	Autosomal dominant polycystic kidney disease with minimal clinical expression unlinked to the PKD1 locus. (8394527)	Wright G.D.... Nevin N.C.	1993	PKD1
49	ACE inhibitors--a potential new group of drugs for treatment of kidney diseases (8477465)	PodrackA! L.... BAPAPr A.	1993	ACE
50	Genetic and clinical studies in autosomal dominant polycystic kidney disease type 1 (ADPKD1). (1583643)	Coto E.... LA^pez-Larrea C.	1992	PKD1

Genes related to kidney disease according to GeneCards:

(show top 50)    (show all 638)

id	Symbol	Description	Score	GeneCards Section Context
1	PKD1	polycystic kidney disease 1 (autosomal dominant)	11.1	Publications, Domains & Families, Transcripts, Aliases & Descriptions (show all 6 sections) Orthologs, Summaries
2	PKD2	polycystic kidney disease 2 (autosomal dominant)	11.1	Databases, Publications, Transcripts, Aliases & Descriptions (show all 7 sections) Summaries, Orthologs, Domains & Families
3	IFT88	intraflagellar transport 88 homolog (Chlamydomonas)	11.1	Summaries, Aliases & Descriptions, Orthologs, Publications
4	PKDREJ	polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)	11.1	Transcripts, Orthologs, Proteins, Aliases & Descriptions (show all 5 sections) Publications
5	UMOD	uromodulin	11.1	Publications, Summaries
6	PKD2L1	polycystic kidney disease 2-like 1	11.1	Publications, Domains & Families, Transcripts, Orthologs (show all 6 sections) Functions, Aliases & Descriptions
7	PKD2L2	polycystic kidney disease 2-like 2	11.1	Orthologs, Proteins, Functions, Aliases & Descriptions (show all 6 sections) Publications, Transcripts
8	PKD1L3	polycystic kidney disease 1-like 3	11.1	Proteins, Aliases & Descriptions, Transcripts, Publications (show all 5 sections) Orthologs
9	PKHD1	polycystic kidney and hepatic disease 1 (autosomal recessive)	11.1	Summaries, Publications
10	PKD1L1	polycystic kidney disease 1 like 1	11.1	Proteins, Orthologs, Aliases & Descriptions, Transcripts (show all 5 sections) Publications
11	PKD1L2	polycystic kidney disease 1-like 2	11.1	Orthologs, Proteins, Aliases & Descriptions, Transcripts (show all 5 sections) Publications
12	HAX1	HCLS1 associated protein X-1	11.1	Publications, Summaries
13	MCKD2	medullary cystic kidney disease 2 (autosomal dominant)	11.0	Aliases & Descriptions
14	PKDTS	polycystic kidney disease, infantile severe, with tuberous sclerosis	11.0	Aliases & Descriptions
15	PKD3	polycystic kidney disease 3 (autosomal dominant)	11.0	Aliases & Descriptions, Publications
16	PKD1P3	polycystic kidney disease 1 (autosomal dominant) pseudogene 3	11.0	Aliases & Descriptions, Publications
17	PKD1P4	polycystic kidney disease 1 (autosomal dominant) pseudogene 4	11.0	Publications, Aliases & Descriptions
18	PKD1P5	polycystic kidney disease 1 (autosomal dominant) pseudogene 5	11.0	Publications, Aliases & Descriptions
19	PKD1P2	polycystic kidney disease 1 (autosomal dominant) pseudogene 2	11.0	Aliases & Descriptions, Publications
20	PKD1P6	polycystic kidney disease 1 (autosomal dominant) pseudogene 6	11.0	Publications, Aliases & Descriptions
21	PKD1P1	polycystic kidney disease 1 (autosomal dominant) pseudogene 1	11.0	Publications, Transcripts, Aliases & Descriptions
22	MCKD1	medullary cystic kidney disease 1 (autosomal dominant)	11.0	Publications, Aliases & Descriptions
23	GFER	growth factor, augmenter of liver regeneration	11.0	Summaries
24	NEK8	NIMA (never in mitosis gene a)- related kinase 8	11.0	Summaries
25	KIF11	kinesin family member 11	11.0	Summaries
26	NEK1	NIMA (never in mitosis gene a)-related kinase 1	11.0	Publications, Summaries
27	HNF1B	HNF1 homeobox B	11.0	Publications
28	NPHP3	nephronophthisis 3 (adolescent)	11.0	Publications
29	PDK2	pyruvate dehydrogenase kinase, isozyme 2	11.0	Publications
30	TSC2	tuberous sclerosis 2	11.0	Publications
31	INVS	inversin	11.0	Publications
32	GLIS2	GLIS family zinc finger 2	11.0	Summaries
33	CFHR5	complement factor H-related 5	11.0	Summaries
34	KIAA0319	KIAA0319	11.0	Summaries
35	PRKCSH	protein kinase C substrate 80K-H	11.0	Publications
36	EPO	erythropoietin	11.0	Publications
37	ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	11.0	Publications
38	TSC1	tuberous sclerosis 1	11.0	Publications
39	NPHP1	nephronophthisis 1 (juvenile)	11.0	Publications
40	CAMP	cathelicidin antimicrobial peptide	11.0	Publications
41	ATF2	activating transcription factor 2	11.0	Publications
42	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	11.0	Publications
43	CLU	clusterin	11.0	Publications
44	HBA2	hemoglobin, alpha 2	11.0	Publications
45	EDNRB	endothelin receptor type B	11.0	Publications
46	EDNRA	endothelin receptor type A	11.0	Publications
47	PAX2	paired box 2	11.0
48	MTOR	mechanistic target of rapamycin (serine/threonine kinase)	11.0	Publications
49	HSD17B12	hydroxysteroid (17-beta) dehydrogenase 12	11.0
50	CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	11.0	Publications

Pathways related to kidney disease according to GeneDecks:

(show top 50)    (show all 179)

id	Pathway	Score	Top Affiliating Genes
1	Molecular Mechanisms of Cancer36	15.6	MYC, BMP6, BMP7, RARA, RAF1, UTS2
2	Pathways in cancer20	14.8	RET, VEGFA, MYC, RARA, MTOR, LAMA4
3	Rho Family GTPases36	14.0	PIP5K1B, VIM, BMP6, BMP7, RAF1, UTS2
4	GnRH Signaling36	14.0	BRAF, RAF1, LAMA3, LAMA4, LAMA5, LAMB1
5	Estrogen Pathway36	13.8	BRAF, BMP6, BMP7, RAF1, UTS2, JUN
6	UPA-UPAR Pathway36	13.8	SERPINE1, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2
7	eNOS Signaling36	13.8	BMP6, BMP7, UTS2, BDKRB1, BDKRB2, ITPR1
8	Pancreatic Adenocarcinoma36	13.4	BRAF, BMP6, BMP7, RAF1, UTS2, CDKN1A
9	GPCR Pathway36	13.4	BRAF, BMP6, BMP7, RAF1, UTS2, JUN
10	NFAT in Immune Response36	12.9	BMP6, BMP7, UTS2, ATF2, FYN, JUN
11	Akt Signaling36	12.9	BMP7, RAF1, UTS2, ITGA1, ITGA2, ITGA6
12	mTOR Pathway36	12.8	BMP6, BMP7, UTS2, INS, INSR, FGF2
13	eIF2 Pathway36	12.7	BRAF, BMP6, BMP7, RAF1, UTS2, INS
14	p70S6K Signaling36	12.7	BMP6, BMP7, RAF1, UTS2, FLT1, INS
15	Rac1 Pathway36	12.7	PIP5K1B, BMP6, BMP7, RAF1, UTS2, LIMK1
16	Endothelin-1 Signaling Pathway36	12.5	BRAF, MYC, BMP6, BMP7, RAF1, FLT1
17	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	12.4	REN, CMA1, BDKRB1, BDKRB2, ATP6AP2, MAPK3
18	MAPK Family Pathway36	12.4	BRAF, BMP6, BMP7, RAF1, UTS2, ATF2
19	Tec Kinases Signaling36	12.1	BMP6, BMP7, UTS2, ITGA1, ITGA2, ITGA4
20	ERK5 Signaling36	12.1	MYC, BMP6, BMP7, UTS2, FOS, FLT1
21	NF-KappaB (p50-p65) Pathway36	12.1	BMP6, BMP7, UTS2, UBD, IRAK1, FLT1
22	TGF-Beta Pathway36	12.0	BMP6, BMP7, UTS2, ATF2, JUN, FOS
23	Glioma Invasiveness36	12.0	BMP6, BMP7, UTS2, ITGA1, ITGA4, ITGA6
24	p53 Mediated Apoptosis36	11.8	BMP6, BMP7, UTS2, FLT1, FGF2, FGF21
25	PPAR Pathway36	11.8	RAF1, UTS2, ITGA1, ITGA2, ITGA4, ITGA6
26	NF-KappaB Family Pathway36	11.7	BMP6, BMP7, UTS2, FYN, IRAK1, FLT1
27	STAT3 Pathway36	11.7	BRAF, MYC, BMP6, BMP7, RAF1, CDKN1A
28	ACE Inhibitor Pathway, Pharmacodynamics34	11.6	CMA1, BDKRB1, BDKRB2, ATP6AP2, MAPK3, CTSG
29	PAK Pathway36	11.6	BMP6, BMP7, UTS2, LIMK1, FLT1, FGF2
30	Actin-Based Motility by Rho Family GTPases36	11.5	PIP5K1B, BMP7, UTS2, LIMK1, ITGA4, ITGA6
31	Cell adhesion ECM remodeling10	11.3	SERPINE1, LAMA3, LAMA4, LAMB1, ITGA1, MMP1
32	Cell adhesion_ECM remodeling41	11.2	SERPINE1, LAMA3, LAMA4, LAMB1, ITGA1, MMP1
33	Transcription Role of VDR in regulation of genes involved in osteoporosis10	11.0	VDR, BGLAP, JUN, FOS, IL6, APOE
34	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	11.0	VDR, BGLAP, JUN, FOS, IL6, APOE
35	Cytokine-cytokine receptor interaction20	10.2	VEGFA, BMP7, LEP, CD40LG, FLT1, IL10
36	Malaria20	10.1	LRP1, SELE, VCAM1, CD36, CD40LG, ITGB2
37	Regulation of actin cytoskeleton20	INF	PIP5K1B, BRAF, RAF1, LIMK1, BDKRB1,
38	Transendothelial Migration of Leukocytes36	INF	VCAM1, , LAMA3, LAMA4, LAMA5, LAMB1
39	p38 Signaling36	INF	BMP6, BMP7, UTS2, ATF2, IRAK1, FLT1
40	Rap1 Pathway36	INF	BRAF, BMP6, BMP7, RAF1, UTS2, FYN
41	Activation of cAMP-Dependent PKA36	INF	BMP7, RAF1, UTS2, ITPR1, FLT1, INSR
42	Signaling Involved in Cardiac Hypertrophy36	INF	BRAF, RAF1, ATF6, ATF2, JUN, ITGA1
43	Activation of PKA through GPCR36	INF	BRAF, BMP6, BMP7, RAF1, UTS2, ITPR1
44	Phospholipase-C Pathway36	INF	BMP6, BMP7, RAF1, UTS2, LAMA3, LAMA4
45	FAK1 Signaling36	INF	BRAF, RAF1, , LAMA3, LAMA4, LAMA5
46	Antioxidant Action of Vitamin-C36	INF	BMP6, BMP7, UTS2, ATF2, JUN, FOS
47	P2Y Receptor Signaling36	INF	BRAF, MYC, RAF1, P2RY12, JUN, FOS
48	Focal adhesion20	INF	VWF, BRAF, RAF1, , LAMA3, LAMA4
49	Integrin Pathway36	INF	PIP5K1B, BRAF, MYC, RAF1, , LAMA3
50	Paxillin Interactions36	INF	UTS2, , ITGA1, ITGA2, ITGA4, ITGA6

Compounds related to kidney disease according to GeneDecks:

(show top 50)    (show all 513)

id	Compound	Score	Top Affiliating Genes
1	arachidonic acid32 9 18 9	18.3	CNR1, VWF, VIM, LPL, LIPC, PAFAH1B1
2	vitamin d32	14.7	LRP1, LRP2, SERPINE1, VIM, NAGLU, LPL
3	cyclic amp32 18	15.2	RET, CNR1, CNR2, PCSK2, BRAF, BDKRB2
4	acetylcholine32 9 18 9	17.1	PIK3C2A, CNR1, VWF, VIM, LPL, BMP6
5	progesterone32 42 9 18 9	17.8	SFRP4, PCSK1, GCK, RBP4, BRAF, BMP7
6	chloride32	13.7	REN, LPA, CLU, KCNN4, SCT, B2M
7	n acetylcysteine32	13.4	VWF, SELE, SERPINC1, NAGLU, VCAM1, RAF1
8	gf 109203x32 42	14.1	VEGFA, RAF1, CFTR, JUN, CDKN1A, MMP1
9	butyrate32	12.9	RET, GCK, VIM, VDR, MYC, BMP6
10	arsenite32 18	13.8	VEGFA, VDR, MYC, RARA, PARP1, MTOR
11	verapamil32 34 9 18 9	16.6	LRP1, REN, NAGLU, MYC, UTS2, UGCG
12	lactacystin32	12.4	SELE, VDR, MYC, RAF1, PARP1, PARK2
13	formaldehyde32 18	13.4	VWF, SELE, VIM, LGALS3, B2M, CFTR
14	procollagen32	12.4	VIM, BMP6, CMA1, BGLAP, PAX5, CD36
15	candesartan32 9 9	14.4	REN, SERPINE1, VEGFA, BDKRB2, MMP1, MMP2
16	sodium dodecylsulfate32	12.3	LRP1, VWF, SERPINE1, LPA, LPL, MYC
17	carbohydrates32	12.2	SELE, NAGA, VCAM1, CLEC12A, BCHE, LGALS3
18	vitamin-e32	12.2	PIK3C2A, RBP4, NAGLU, LPA, VCAM1, RARA
19	mannitol32 9 9	14.0	GCKR, GCK, NAGLU, VCAM1, SCT, XDH
20	imatinib32 34 9 9	14.8	RET, BRAF, VEGFA, MYC, BMP6, RARA
21	carbachol32 9 9	13.8	SCT, CFTR, MAPK10, TRPC3, PTH, SST
22	pdtc32	11.8	GCLM, SELE, VCAM1, RAF1, PARP1, XDH
23	l-nmma32	11.8	VCAM1, BDKRB2, XDH, INSR, CAT, GH1
24	5-hydroxytryptamine32	11.6	CNR1, SERPINE1, VIM, BMP6, RAF1, CFTR
25	diphenyleneiodonium32	11.5	VEGFA, VCAM1, XDH, MPO, JUN, INSR
26	egcg32	11.4	RAF1, LDLR, MAPK3, MAPK10, MAP3K1, CCL5
27	desmopressin32 42 9 9	14.3	REN, VWF, SERPINC1, SERPINE1, NAGLU, B2M
28	theophylline32 9 18 9	14.3	LPL, MYC, RAF1, XDH, B2M, CD79A
29	cocaine32 9 9	13.2	PIK3C2A, CNR1, SELE, VIM, VCAM1, BMP6
30	dmso32	11.2	VIM, BMP6, BDKRB2, XDH, CFTR, CD36
31	probucol32 9 9	13.1	SELE, LPL, VCAM1, LIPC, LDLR, LCAT
32	cyclophosphamide32 34 9 9	14.1	ITGA4, ITGB2, CYP2C8, NPHS2, NPPB
33	gemfibrozil32 9 9	13.1	PIK3C2A, VIM, LPA, LPL, LIPC, LDLR
34	silymarin32	10.9	VEGFA, BMP6, PARP1, XDH, JUN, MMP2
35	deoxypyridinoline32	10.9	VDR, BGLAP, PAX5, CD36, MMP3, IGFBP2
36	adriamycin32	10.8	VIM, VDR, MYC, UGCG, B2M, CDKN1A
37	quercetin32 42 9 18 9	14.8	PIK3C2A, SELE, VCAM1, RAF1, PARP1, XDH
38	estrone32 9 18 9	13.7	LPL, BGLAP, LEP, APOB, IGF2, IGFBP2
39	apocynin32	10.7	SELE, VCAM1, XDH, MPO, JUN, ICAM1
40	alpha tocopherol32	10.6	RBP4, LPL, VCAM1, BGLAP, LEP, LDLR
41	chloroquine32 34 9 9	13.4	SERPINC1, BMP6, RAF1, LDLR, B2M, CFTR
42	menadione32 9 18 9	13.4	VKORC1, BGLAP, MTHFR, XDH, IRAK1, GSR
43	polymyxin b32	9.6	SELE, SERPINE1, VCAM1, LDLR, CD14, ITGB2
44	threonine32	INF	RET, RAF1, LIMK1, PARK2, PAX2, BDKRB2
45	herbimycin a32 42	INF	RET, SELE, VCAM1, MYC, BMP6, RAF1
46	genistein32 9 18 9	INF	RET, SELE, SERPINE1, VIM, VEGFA, LPL
47	vegf32	INF	PIK3C2A, LRP1, KL, REN, RET, RETN
48	hydrogen32 18	INF	CNR2, PCSK9, GCK, RARA, , SCT
49	estrogen32	INF	RETN, VWF, PCSK1, RBP4, SERPINC1, SERPINE1
50	wortmannin32 42	INF	PIK3C2A, RET, VIM, BRAF, VCAM1, RAF1

Cellular components related to kidney disease according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	INF	PIP5K1B, PIK3C2A, KIF3A, KIF11, PCK1, GCKR
2	plasma membrane	GO:005886	INF	PIK3C2A, LRP2, LRP8, KL, CNR1, CNR2
3	cytoplasm	GO:005737	INF	PIK3C2A, LRP1, LRRC6, KIF12, KIF11, SFRP4
4	extracellular region	GO:005576	17.7	LRP8, KL, RETN, CNDP1, VWF, SERPINC1
5	extracellular space	GO:005615	17.5	LRP2, KL, REN, SFRP4, PCSK9, PCSK2
6	apical plasma membrane	GO:016324	12.6	LRP2, MYO7B, UMOD, CFTR, AQP1, AQP2
7	extracellular matrix	GO:031012	12.3	VWF, SERPINE1, LPL, CMA1, CLU, LGALS3
8	proteinaceous extracellular matrix	GO:005578	12.3	VWF, VEGFA, LGALS3, CD248, MMP1, MMP12
9	cell surface	GO:009986	12.3	SFRP4, PCSK9, VEGFA, LPL, VCAM1, RARA
10	endoplasmic reticulum lumen	GO:005788	11.9	B2M, INS, APOA1, APOA4, APOB, F7
11	membrane raft	GO:045121	11.8	SELE, UMOD, CD79A, CD36, CD14, ITGA1
12	platelet alpha granule lumen	GO:031093	11.5	VWF, SERPINE1, VEGFA, CLU, FN1, FGB
13	external side of plasma membrane	GO:009897	10.9	VWF, VCAM1, LDLR, B2M, ATP6AP2, CD79A
14	integral to plasma membrane	GO:005887	INF	LRP1, KL, RET, CNR1, CNR2, BTN2A1
15	basolateral plasma membrane	GO:016323	INF	UMOD, CFTR, , AQP1, AQP2, AQP3

Biological processes related to kidney disease according to GeneDecks:

(show top 50)    (show all 60)

id	Name	GO ID	Score	Top Affiliating Genes
1	small molecule metabolic process	GO:044281	16.0	PIP5K1B, PIK3C2A, LRP2, PCSK1, PCK1, GCKR
2	signal transduction	GO:007165	14.4	LRP8, RET, NAMPT, VDR, RARA, RAF1
3	negative regulation of apoptotic process	GO:043066	14.1	SERPINE1, BRAF, VEGFA, MYC, RAF1, CLU
4	positive regulation of transcription from RNA polymerase II promoter	GO:045944	14.1	SERPINE1, VEGFA, VDR, MYC, BMP6, RARA
5	negative regulation of cell proliferation	GO:008285	13.0	SFRP4, VHL, VDR, BNIPL, RAF1, BDKRB2
6	axon guidance	GO:007411	13.0	RAF1, LIMK1, LAMB1, LAMB2, FYN, CDH4
7	positive regulation of cell proliferation	GO:008284	13.0	NAMPT, VEGFA, MYC, RARA, LEP, BAMBI
8	positive regulation of transcription, DNA-dependent	GO:045893	13.0	RET, VHL, MYC, BMP7, RARA, PAX2
9	extracellular matrix organization	GO:030198	12.8	CMA1, LGALS3, ITGA8, MMP1, MMP2, MMP3
10	cellular response to hypoxia	GO:071456	12.7	VHL, VEGFA, BMP7, BDKRB2, MTOR, AQP1
11	kidney development	GO:001822	12.6	REN, PCSK9, BMP6, INVS, AQP11, CA2
12	angiogenesis	GO:001525	12.6	SERPINE1, VEGFA, LAMA5, JUN, JAG1, MMP2
13	response to hypoxia	GO:001666	12.4	VEGFA, VCAM1, RAF1, UTS2, LEP, UCP3
14	response to drug	GO:042493	12.4	LRP2, REN, PCSK1, GCLM, NAT8, LPL
15	response to lipopolysaccharide	GO:032496	12.3	CNR1, CNR2, PCSK1, SELE, BDKRB1, S100A8
16	aging	GO:007568	12.2	LRP2, KL, CNR1, VDR, VCAM1, UCP3
17	lipid metabolic process	GO:006629	12.2	LRP2, LRP8, BTN2A1, LPA, LPL, CLU
18	regulation of blood pressure	GO:008217	12.2	REN, UTS2, LEP, GNB3, CALCA, HMOX1
19	transforming growth factor beta receptor signaling pathway	GO:007179	12.2	SERPINE1, MYC, PARP1, BAMBI, MSTN, JUN
20	organ morphogenesis	GO:009887	12.2	BRAF, VDR, PAX4, PAX5, ITGA2, FLI1
21	inflammatory response	GO:006954	12.2	CNR2, SELE, BMP6, BDKRB1, BDKRB2, S100A8
22	cell surface receptor signaling pathway	GO:007166	12.2	BDKRB2, CD36, CD14, MIF, CCL2, CCR5
23	positive regulation of angiogenesis	GO:045766	12.1	SERPINE1, VEGFA, UTS2, MMP9, FLT1, FGF2
24	ossification	GO:001503	12.1	BMP7, MMP9, MGP, IGF2, IBSP, CASR
25	positive regulation of apoptotic process	GO:043065	12.1	CNR1, SFRP4, CLU, UBD, MSX2, ITGA6
26	platelet degranulation	GO:002576	11.9	VWF, SERPINE1, VEGFA, CLU, CD36, FN1
27	positive regulation of protein phosphorylation	GO:001934	11.9	VEGFA, MTOR, INSR, MAPK3, IGF2, F2
28	positive regulation of NF-kappaB transcription factor activity	GO:051092	11.9	CLU, IRAK1, INS, GREM1, IL6, ICAM1
29	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	11.8	LRP8, VEGFA, MTOR, CD36, MIF, INS
30	response to estradiol stimulus	GO:032355	11.8	SFRP4, VDR, RARA, MMP9, INSR, ENO2
31	positive regulation of nitric oxide biosynthetic process	GO:045429	11.7	INS, INSR, IFNG, ICAM1, AKT1, TNF
32	response to vitamin D	GO:033280	11.7	LRP2, BGLAP, INSR, AQP3, ALPL, PTGS2
33	response to glucocorticoid stimulus	GO:051384	11.6	SFRP4, PCSK1, SERPINE1, BGLAP, BCHE, UCP3
34	positive regulation of protein kinase B signaling cascade	GO:051897	11.5	MTOR, INS, INSR, GPX1, IGF2, IGF1
35	anti-apoptosis	GO:006916	11.5	BRAF, VHL, PAX2, MPO, CD40LG, IRAK1
36	response to peptide hormone stimulus	GO:043434	11.3	SFRP4, PCSK1, BRAF, FAS, GNAI1, CTGF
37	cell-cell signaling	GO:007267	11.3	PCSK1, NAMPT, ITGB2, INS, FGF21, FGFR2
38	cholesterol metabolic process	GO:008203	11.3	PCSK9, LIPC, LEP, LDLR, LCAT, CETP
39	lipoprotein metabolic process	GO:042157	11.3	PCSK9, LPA, LPL, LDLR, LCAT, CETP
40	response to ethanol	GO:045471	11.2	CNR1, RBP4, BGLAP, S100A8, MSTN, FYN
41	female pregnancy	GO:007565	11.2	LEP, FLT1, AQP2, GPX3, IGFBP2, IDO1
42	response to mechanical stimulus	GO:009612	11.2	BGLAP, JUN, MMP9, MGP, ANGPT2, CCL2
43	leukocyte migration	GO:050900	11.2	FYN, CD177, ITGA4, ITGA6, ITGB2, MMP1
44	cholesterol homeostasis	GO:042632	10.5	PCSK9, LIPC, LDLR, LCAT, CETP, APOA1
45	proteolysis	GO:006508	INF	LRP8, REN, CNDP1, PCSK2, PCSK1, VHL
46	blood coagulation	GO:007596	INF	LRP8, KIF3A, KIF11, VWF, SERPINC1, SERPINE1
47	platelet activation	GO:030168	INF	VWF, SERPINE1, VEGFA, RAF1, CLU,
48	insulin receptor signaling pathway	GO:008286	INF	PIK3C2A, KL, NAMPT, RAF1, , MTOR
49	positive regulation of cell migration	GO:030335	INF	RET, VEGFA, , LAMB1, FLT1, INS
50	heart development	GO:007507	INF	RBP4, VCAM1, RAF1, ITGA4, FOXC2, FBN1

Molecular functions related to kidney disease according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein homodimerization activity	GO:042803	14.2	TSC2, ACTN4, WWTR1, PDK2, PDGFA, PKD2
2	protein heterodimerization activity	GO:046982	13.2	PDK2, PDGFA, RXRA, CYBA, TP53, ERBB2
3	receptor binding	GO:005102	12.4	MIF, FGB, FGG, ANGPT2, ANGPTL4, CCL2
4	hormone activity	GO:005179	12.1	SST, EDN1, AGT, TTR, STC1, NPPA
5	extracellular matrix structural constituent	GO:005201	11.8	COL1A2, COL3A1, COL14A1, COL4A3, COL4A4, ELN
6	integrin binding	GO:005178	11.2	CTGF, COL3A1, COL4A3, ACTN4, THBS1, LYN
7	growth factor activity	GO:008083	11.1	EGF, PDGFA, NGF, CTGF, GH1, AGT
8	heparin binding	GO:008201	11.1	CCL2, APOE, APOB, APOA5, CCL5, HSD17B12
9	cytokine activity	GO:005125	10.5	IL6, IFNG, HMGB1, TNF, TNFRSF11B, TNFSF10
10	protein binding	GO:005515	INF	RHOA, ACE, ACSS1, ACTN4, ELN, E4F1
11	enzyme binding	GO:019899	INF	PTGS2, CYP2E1, PPARG, PLAUR, , RXRA