MCID: KDN018
MIFTS: 52

Kidney Disease malady

Summaries for Kidney Disease

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33MalaCards
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MalaCards: Kidney Disease, also known as kidney diseases, is related to polycystic kidney disease and polycystic kidney disease, autosomal dominant. An important gene associated with Kidney Disease is PKD2 (polycystic kidney disease 2 (autosomal dominant)). The drugs dopamine and dopamine hydrochloride and the compounds trp-p-2 and la3+ have been mentioned in the context of this disorder. Related mouse phenotype renal/urinary system.

Aliases & Classifications for Kidney Disease

Sources:
8Disease Ontology, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

kidney disease 8
kidney diseases 61


External Ids:

Disease Ontology8 DOID:557
MeSH35 D007674

Related Diseases for Kidney Disease

Sources:
17GeneCards, 18GeneDecks
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Diseases in the chronic kidney failure family:

acute kidney failure kidney disease

Diseases related to Kidney Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 396)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic kidney disease32.0PKD1, PKHD1
2polycystic kidney disease, autosomal dominant31.8PKD1, PKD2
3polycystic kidney disease, autosomal recessive31.2IFT88, PKHD1, PKD2, PKD1
4nephronophthisis30.8PKD1, PKD2, UMOD
5aneurysm disease30.8PKD1, PKD2
6polycystic liver disease30.8PKHD1, PKD2, PKD1, PKD1P6
7congenital hepatic fibrosis30.7PKHD1
8uromodulin-associated kidney disease30.7MCKD2, UMOD
9umod-associated kidney disease30.6MCKD2, UMOD
10polycystic kidney disease, type 230.5PKD1, PKD2
11tuberous sclerosis30.5PKHD1, PKD1, PKD1P6
12primary hyperoxaluria30.3UMOD, PKHD1, PKD2, PKD1
13glomerulocystic kidney disease with hyperuricemia and isosthenuria30.2MCKD2, UMOD
14autosomal dominant disease11.2
15kid syndrome10.8
16autosomal recessive disease10.8
17vascular disease10.7
18lip disease10.6
19insulin resistance10.6
20autosomal genetic disease10.6
21hyperphosphatemia10.5
22medullary cystic kidney disease type 110.5
23hyperuricemia10.5
24aortic disease10.5
25hemoglobin d disease10.5
26hemoglobin c disease10.5
27kidney hypertrophy10.4
28ren-related kidney disease10.4
29n syndrome10.4
30atherosclerosis10.4
31hepatitis c10.4
32metabolic acidosis10.4
33hepatitis d10.4
34brain disease10.4
35nutrition disease10.4
36coronary artery disease,10.4
37hemoglobin e disease10.4
38nephritis10.4
39gout10.3
40renal osteodystrophy10.3
41polycystic kidney disease, type 110.3
42cardiovascular disease risk factor10.3
43deficiency anemia10.3
44intracranial aneurysm10.3
45nephrolithiasis10.3
46nephrogenic systemic fibrosis10.3
47fatty liver disease10.3
48iron deficiency anemia10.3
49lupus nephritis10.3
50alport syndrome10.3

Graphical network of the top 20 diseases related to Kidney Disease:



Diseases related to kidney disease

Clinical Features for Kidney Disease

Drugs & Therapeutics for Kidney Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Kidney Disease

Drug clinical trials:

Search ClinicalTrials for Kidney Disease

Search NIH Clinical Center for Kidney Disease

Search CenterWatch for Kidney Disease

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Kidney Disease

Anatomical Context for Kidney Disease

Animal Models for Kidney Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Kidney Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536711.4PKD1, PKD2, PKHD1, PKD1L1, UMOD, IFT88

Publications for Kidney Disease

Sources:
51PubMed
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Articles related to Kidney Disease:

(show top 50)    (show all 3369)
idTitleAuthorsYear
1
Is lead chelation therapy effective for chronic kidney disease? A meta-analysis. (24341661)
2014
2
Incremental prognostic information from kidney function in patients with new onset coronary heart disease. (24332146)
2014
3
Kidney disease in HIV-infected patients. (24142615)
2013
4
Hyperuricemia is associated with hypertension, obesity, and albuminuria in children with chronic kidney disease. (22809658)
2013
5
Bilateral papillary renal cell carcinoma and angiomyolipoma in the patients with autosomal dominant polycystic kidney disease: case report of two cases and literature review. (24375046)
2013
6
Physical therapy during hemodialyse in patients with chronic kidney disease. (24100735)
2013
7
Lupus nephritis and end-stage kidney disease. (23370533)
2013
8
Global kidney disease. (24120195)
2013
9
Vitamin K status in chronic kidney disease. (24212088)
2013
10
Inhibition of Comt with tolcapone slows progression of polycystic kidney disease in the more severely affected PKD/Mhm (cy/+) substrain of the Hannover Sprague-Dawley rat. (23543593)
2013
11
Updated guidelines for managing chronic kidney disease. (24103894)
2013
12
Prognostic factors and clinical outcomes of acute intracerebral hemorrhage in patients with chronic kidney disease. (24294452)
2013
13
Urinary neutrophil gelatinase-associated lipocalin as a predictor of cardiovascular events in patients with chronic kidney disease. (24378882)
2013
14
A comparison of the effects of losartan and ramipril on blood pressure, renal volume and progression in polycystic kidney disease: A 5-Year follow-up. (23935270)
2012
15
Circulating FGF21 levels are progressively increased from the early to end stages of chronic kidney diseases and are associated with renal function in Chinese. (21525989)
2011
16
Successful peritoneal dialysis after renal transcatheter arterial embolization in autosomal dominant polycystic kidney disease. (22014637)
2011
17
Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseases. (20686651)
2010
18
Renal cell carcinoma in acquired cystic kidney disease. (20459539)
2010
19
Diagnosis of feline polycystic kidney disease by a combination of ultrasonographic examination and PKD1 gene analysis. (21257442)
2010
20
Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK. (20150538)
2010
21
Postprandial hyperglycemia and hyperinsulinemia associated with renal arterio-arteriolosclerosis in chronic kidney disease. (20186145)
2010
22
Autosomal dominant polycystic kidney disease with cystic haemorrhage and infection. (21268963)
2010
23
Cardiovascular autonomic dysfunction in a novel rodent model of polycystic kidney disease. (19825515)
2010
24
Overweight, obesity and metabolic alterations in chronic kidney disease. (20087247)
2009
25
Role of vitamin D in chronic kidney disease. (19371802)
2009
26
Vitamin D affects survival independently of vascular calcification in chronic kidney disease. (19443628)
2009
27
Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney are the same disease entity: molecular and histologic evidence. (18971776)
2009
28
Collecting duct carcinoma with acquired cystic disease of the kidney in a long-term hemodialysis patient. (18184183)
2008
29
Hypertension in children with chronic kidney disease: pathophysiology and management. (17990006)
2008
30
Chronic kidney disease and bone fracture: a growing concern. (18563052)
2008
31
Should all patients with chronic kidney disease take a statin? (18290355)
2008
32
Expression of ACE and ACE2 in individuals with diabetic kidney disease and healthy controls. (18371537)
2008
33
A case-control study of the effects of nephrolithiasis in cats with chronic kidney disease. (17571990)
2007
34
Eleven reasons to control the protein intake of patients with chronic kidney disease. (17592471)
2007
35
Abnormal prion protein in ectopic lymphoid tissue in a kidney of an asymptomatic white-tailed deer experimentally inoculated with the agent of chronic wasting disease. (16672586)
2006
36
Orexigenic and anorexigenic mechanisms in the control of nutrition in chronic kidney disease. (15662537)
2005
37
Oxidative and nitrosative stress in kidney disease: a case for cyclosporine A. (16245254)
2005
38
Feline polycystic kidney disease mutation identified in PKD1. (15466259)
2004
39
Autosomal dominant polycystic kidney disease (ADPKD, MIM 173900, PKD1 and PKD2 genes, protein products known as polycystin-1 and polycystin-2). (14872199)
2004
40
Role of VEGF in kidney development, microvascular maintenance and pathophysiology of renal disease. (12872442)
2003
41
Tissue and cellular localization of a novel polycystic kidney disease-like gene product, polycystin-L. (11805156)
2002
42
Basolateral chloride transporters in autosomal dominant polycystic kidney disease. (12355171)
2002
43
Novel PKD1 deletions and missense variants in a cohort of Hellenic polycystic kidney disease families. (11571556)
2001
44
Autosomal dominant polycystic kidney disease: modification of disease progression. (11705510)
2001
45
Molecular genetics and mechanism of autosomal dominant polycystic kidney disease. (10655152)
2000
46
A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans. (10517638)
1999
47
Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene. (10594243)
1999
48
Vocal cord paralysis and cystic kidney disease in Hajdu-Cheney syndrome. (9184252)
1997
49
Glomerulocystic kidney disease associated with Wegener's granulomatosis and membranous glomerulonephritis: a case report. (7566625)
1995
50
UMOD-Associated Kidney Disease (20301530)
1993

Genetic Variations for Kidney Disease

Expression for genes affiliated with Kidney Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Kidney Disease

Search GEO for disease gene expression data for Kidney Disease.

Pathways for genes affiliated with Kidney Disease

Compounds for genes affiliated with Kidney Disease

Sources:
45Novoseek, 29IUPHAR
See all sources

Compounds related to Kidney Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1trp-p-24510.8PKD1, PKD2
2la3+2910.8PKD2, PKD2L1
3cai2+2910.7PKD2, PKD2L1
4gd3+2910.5PKD2, PKD2L1

GO Terms for genes affiliated with Kidney Disease

Sources:
16Gene Ontology
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Cellular components related to Kidney Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ciliumGO:00592911.2PKD1, PKD2, PKD1L1, IFT88
2motile primary ciliumGO:03151211.1IFT88, PKD2, PKD1
3microtubule basal bodyGO:00593210.9IFT88, PKHD1, PKD2
4polycystin complexGO:00213310.8PKD1, PKD2
5primary ciliumGO:07237210.8PKHD1, UMOD
6mitotic spindleGO:07268610.5PKD2, PKHD1

Biological processes related to Kidney Disease according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1detection of mechanical stimulusGO:05098211.8PKD2, PKD1L1, PKD1, PKDREJ, PKD2L2, PKD2L1
2calcium ion transmembrane transportGO:07058811.8PKD2L2, PKD1, PKD2, PKD2L1, PKD1L1, PKDREJ
3neuropeptide signaling pathwayGO:00721811.4PKD1L3, PKD1L2, PKD1, PKDREJ
4metanephric ascending thin limb developmentGO:07221811.3UMOD, PKD1, PKD2
5detection of nodal flowGO:00312711.1PKD1L1, PKD2
6detection of chemical stimulus involved in sensory perception of sour tasteGO:00158111.1PKD2L1, PKD1L3
7mesonephric tubule developmentGO:07216411.1PKD1, PKD2
8mesonephric duct developmentGO:07217711.0PKD2, PKD1
9cellular response to acidityGO:07146811.0PKD2L1, PKD1L3
10positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycGO:03165911.0PKD1, PKD2
11placenta blood vessel developmentGO:06067411.0PKD2, PKD1
12cytoplasmic sequestering of transcription factorGO:04299410.9PKD2, PKD1
13sodium ion transmembrane transportGO:03572510.9PKD2L1, PKD2
14spinal cord developmentGO:02151010.9PKD2, PKD1
15cation transportGO:00681210.8PKD2L1, PKD1L3
16JAK-STAT cascadeGO:00725910.8PKD1, PKD2
17neural tube developmentGO:02191510.7PKD1, PKD2
18embryonic placenta developmentGO:00189210.5PKD1, PKD2

Molecular functions related to Kidney Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium channel activityGO:00526211.4PKD1, PKD1L1, PKD2L1, PKD2L2, PKDREJ
2calcium ion bindingGO:00550911.3PKDREJ, PKD2L2, PKD2, UMOD, PKD1L2, PKD2L1
3cation channel activityGO:00526111.0PKD1, PKD1L3, PKD2L1
4carbohydrate bindingGO:03024611.0PKD1, PKD1L2, PKD1L3
5sour taste receptor activityGO:03304010.8PKD2L1, PKD1L3
6cation transmembrane transporter activityGO:00832410.5PKD2L1, PKD1L3

Products for genes affiliated with Kidney Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Kidney Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet