MCID: KDN018
MIFTS: 62

Kidney Disease malady

Genetic diseases, Nephrological diseases, Rare diseases, Fetal diseases categories
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Summaries for Kidney Disease

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33MalaCards
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MalaCards: Kidney Disease, also known as kidney diseases, is related to polycystic kidney disease and cystic kidney. An important gene associated with Kidney Disease is PKD2 (polycystic kidney disease 2 (autosomal dominant)), and among its related pathways are Selected targets of HNF1 and Adenylate cyclase activating neuropeptides. The drugs dopamine and dopamine hydrochloride and the compounds trp-p-2 and slex have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and heart, and related mouse phenotypes are liver/biliary system and respiratory system.

Aliases & Classifications for Kidney Disease

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8Disease Ontology, 62UMLS, 40NCIt, 58SNOMED-CT, 35MeSH
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Classifications:



Aliases & Descriptions:

kidney disease 8
kidney diseases 62


External Ids:

Disease Ontology8 DOID:557
MeSH35 D007674

Related Diseases for Kidney Disease

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17GeneCards, 18GeneDecks
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Diseases in the Chronic Kidney Failure family:

Acute Kidney Failure kidney disease
Renal Infectious Disease Ren-Related Kidney Disease
Renal Dysplasia

Diseases related to Kidney Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 437)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic kidney disease32.0IFT88, PKD1, PKHD1, PKD2, PKD2L1, UMOD
2cystic kidney31.4UMOD, PKD2, PKHD1, PKD1
3nephronophthisis30.9PKD1, PKD2, UMOD
4congenital hepatic fibrosis30.8PKHD1
5familial juvenile hyperuricaemic nephropathy30.7UMOD, MCKD2
6polycystic kidney disease, type 230.7PKD1, PKD2
7polycystic kidney disease, autosomal dominant30.7PKD1, PKD2
8umod-associated kidney disease30.6UMOD, MCKD2
9polycystic kidney disease, autosomal recessive30.6IFT88, PKD1, PKHD1, PKD2
10tuberous sclerosis30.5PKD1, PKHD1
11polycystic liver disease30.5PKD2, PKHD1, PKD1
12chronic kidney failure30.5UMOD, PKD2, PKD1
13intracranial aneurysm30.4PKD2, PKD1
14primary hyperoxaluria30.3UMOD, PKD2, PKHD1, PKD1
15glomerulocystic kidney disease with hyperuricemia and isosthenuria30.2MCKD2, UMOD
16caroli disease30.1PKD1, PKHD1
17hypertension10.7
18proteinuria10.6
19hepatitis10.6
20endotheliitis10.5
21insulin resistance10.5
22hyperparathyroidism10.5
23medullary cystic kidney disease type 110.5
24diabetes mellitus10.5
25obesity10.5
26aneurysm10.5
27renal cell carcinoma10.4
28hyperphosphatemia10.4
29peritonitis10.4
30hyperuricemia10.4
31polycystic kidney disease, type 110.4
32atherosclerosis10.3
33metabolic acidosis10.3
34liver disease10.3
35end stage renal failure10.3
36periodontitis10.3
37vascular disease10.3
38gout10.3
39renal osteodystrophy10.3
40glomerulonephritis10.3
41nephritis10.3
42hepatitis c10.2
43nephrolithiasis10.2
44type 2 diabetes mellitus10.2
45nephrogenic systemic fibrosis10.2
46lupus nephritis10.2
47polycystic kidney disease, type 310.2
48deficiency anemia10.2
49alport syndrome10.2
50iron deficiency anemia10.2

Graphical network of the top 20 diseases related to Kidney Disease:



Diseases related to kidney disease

Symptoms for Kidney Disease

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Drugs & Therapeutics for Kidney Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Kidney Disease

Search NIH Clinical Center for Kidney Disease

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Kidney Disease

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Anatomical Context for Kidney Disease

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33MalaCards
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MalaCards organs/tissues related to Kidney Disease:

33
Kidney, Bone, Heart, Liver, Endothelial, Brain, Testes, Monocytes, Thyroid, Pituitary, Skin, Skeletal muscle, Lung, Spinal cord, T cells, Pineal, Appendix, Pancreas, Myeloid, Colon, Prostate, Bone marrow

Animal Models for Kidney Disease or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Kidney Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.7PKD2, PKHD1, PKD1, IFT88, MUC1
2MP:00053889.5NEK8, IFT88, PKD1, PKHD1, PKD2, PKD1L1
3MP:00053679.4UMOD, NEK8, IFT88, PKD1, PKHD1, PKD2
4MP:00053819.4MUC1, IFT88, PKD1, PKHD1, PKD2, PKD1L1
5MP:00053788.9HAX1, NEK8, IFT88, PKD1, PKHD1, PKD2

Publications for Kidney Disease

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52PubMed
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Articles related to Kidney Disease:

(show top 50)    (show all 2991)
idTitleAuthorsYear
1
Small tumour size is associated with new-onset chronic kidney disease after radical nephrectomy in patients with renal cell carcinoma. (24060356)
2014
2
Bilateral nephrectomy significantly improves health-related quality of life in a hemodialysis patient with autosomal dominant polycystic kidney disease. (24041611)
2013
3
Baseline characteristics in the Bardoxolone methyl EvAluation in patients with Chronic kidney disease and type 2 diabetes mellitus: the Occurrence of renal eveNts (BEACON) trial. (24169612)
2013
4
Pre-eclampsia or chronic kidney disease? The flow hypothesis. (23314318)
2013
5
Periodontitis and chronic kidney disease: a systematic review of the association of diseases and the effect of periodontal treatment on estimated glomerular filtration rate. (23432795)
2013
6
Kidney disease in HIV-infected patients. (24142615)
2013
7
Changing referral characteristics of patients with autosomal dominant polycystic kidney disease. (23830538)
2013
8
Global kidney disease. (24120193)
2013
9
Factors related to nephrotic-range proteinuria in late-stage chronic kidney disease patients with diabetes mellitus. (23355027)
2013
10
Growth Retardation in Children with Kidney Disease. (24187550)
2013
11
Complete staghorn calculus in polycystic kidney disease: infection is still the cause. (24070202)
2013
12
Acute myocardial infarction in patients with chronic kidney disease: how are the most vulnerable patients doing? (23903416)
2013
13
Multiple liver cyst infection caused by Salmonella ajiobo in autosomal dominant polycystic kidney disease. (23053500)
2013
14
Pregnancy management and outcome in women with chronic kidney disease. (24376324)
2013
15
Diet and kidney disease in high-risk individuals with type 2 diabetes mellitus. (23939297)
2013
16
Increasing extracellular matrix collagen level and MMP activity induces cyst development in polycystic kidney disease. (22963260)
2012
17
Somatotroph pituitary adenoma with acromegaly and autosomal dominant polycystic kidney disease: SSTR5 polymorphism and PKD1 mutation. (21744088)
2012
18
A case of severe aortic valve regurgitation caused by an ascending aortic aneurysm in a young patient with autosomal dominant polycystic kidney disease and normal renal function. (22396705)
2012
19
Right ventricular dysfunction is associated with chronic kidney disease and predicts survival in patients with chronic systolic heart failure. (22357576)
2012
20
Proteinuria as a risk marker for the progression of chronic kidney disease in patients on predialysis care and the role of angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker treatment. (23128440)
2012
21
Aquaretic treatment in polycystic kidney disease. (23121376)
2012
22
Association of plasma renin activity and aldosterone-renin ratio with prevalence of chronic kidney disease: the Kaiser Permanente Southern California cohort. (21941205)
2011
23
Disseminated hydatid disease mistaken for polycystic kidney disease by ultrasound. (21116276)
2010
24
Cardiovascular autonomic neuropathy in chronic kidney diseases. (21485597)
2010
25
Endothelin, hypertension and chronic kidney disease: new insights. (20051851)
2010
26
Spontaneous coronary artery dissection in a woman with polycystic kidney disease. (18992981)
2009
27
Effect of spironolactone on left ventricular mass and aortic stiffness in early-stage chronic kidney disease: a randomized controlled trial. (19643310)
2009
28
25-Hydroxyvitamin D deficiency and inflammation and their association with hemoglobin levels in chronic kidney disease. (19218791)
2009
29
Morphological and functional features of hepatic cyst epithelium in autosomal dominant polycystic kidney disease. (18202196)
2008
30
Intravenous iron in chronic kidney disease: haemoglobin change shortly after treatment of patients neither on dialysis nor on erythropoietin. (18786076)
2008
31
Nutrition assessment and hormonal influences on body composition in children with chronic kidney disease. (17395125)
2007
32
Study of the association of -667 aquaporin-2 (AQP-2) A/G promoter polymorphism with the incidence and clinical course of chronic kidney disease in Korea. (17763164)
2007
33
Heightened epithelial Na+ channel-mediated Na+ absorption in a murine polycystic kidney disease model epithelium lacking apical monocilia. (16207792)
2006
34
From gene to disease; PKHD1 and recessive polycystic kidney disease]. (15771341)
2005
35
Darbepoetin alfa: its use in anemia associated with chronic kidney disease. (16207074)
2005
36
Low-dose atorvastatin in severe chronic kidney disease patients: a randomized, controlled endpoint study. (18161210)
2005
37
Matrix GLA protein gene polymorphisms: clinical correlates and cardiovascular mortality in chronic kidney disease patients. (16210837)
2005
38
Orexigenic and anorexigenic mechanisms in the control of nutrition in chronic kidney disease. (15662537)
2005
39
Oxidative stress and renal injury with intravenous iron in patients with chronic kidney disease. (15149341)
2004
40
The ENOS polymorphism is not associated with severity of renal disease in polycystic kidney disease 1. (12500225)
2003
41
De novo HNF-1 beta gene mutation in familial hypoplastic glomerulocystic kidney disease. (12478351)
2002
42
Morbidity from congenital hepatic fibrosis after renal transplantation for autosomal recessive polycystic kidney disease. (12118859)
2002
43
A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish. (12421721)
2002
44
Novel PKD1 deletions and missense variants in a cohort of Hellenic polycystic kidney disease families. (11571556)
2001
45
Free oxygen radiacals and kidney diseases--part I]. (11320727)
2000
46
A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans. (10517638)
1999
47
Polycystic kidney disease in SBM transgenic mice: role of c-myc in disease induction and progression. (9422539)
1998
48
Cystic kidney diseases. (9263671)
1997
49
The etiology, pathogenesis, and treatment of autosomal dominant polycystic kidney disease: recent advances. (8957030)
1996
50
Transgenic mouse model of kidney disease: insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome. (1696177)
1990

Variations for Kidney Disease

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Expression for genes affiliated with Kidney Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Kidney Disease

Search GEO for disease gene expression data for Kidney Disease.

Pathways for genes affiliated with Kidney Disease

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50PathCards, 12EMD Millipore
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Pathways related to Kidney Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2UMOD, PKD2
210.1PKD1L1, PKD1L2

Compounds for genes affiliated with Kidney Disease

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45Novoseek, 29IUPHAR
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Compounds related to Kidney Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1trp-p-24510.3PKD2, PKD1
2slex4510.2UMOD, MUC1
3cai2+2910.1PKD2L1, PKD2
4gd3+2910.0PKD2, PKD2L1
5la3+299.8PKD2L1, PKD2

GO Terms for genes affiliated with Kidney Disease

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16Gene Ontology
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Cellular components related to Kidney Disease according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1polycystin complexGO:00213310.3PKD1, PKD2
2motile primary ciliumGO:03151210.2PKD2, PKD1, IFT88
3primary ciliumGO:07237210.2UMOD, PKHD1, NEK8
4ciliary basal bodyGO:03606410.1PKD2, PKHD1, IFT88
5mitotic spindleGO:07268610.1PKD2, PKHD1
6ciliary membraneGO:06017010.1UMOD, PKD2L1, PKD1L1, PKD2
7ciliumGO:00592910.0IFT88, PKD1, PKD2, PKD1L1
8cell surfaceGO:0099869.7MUC1, PKD1L2, PKD1L3, PKD2L1
9apical plasma membraneGO:0163249.7MUC1, PKHD1, UMOD
10extracellular vesicular exosomeGO:0700629.5MUC1, PKD1, PKHD1, PKD2, PKD1L3, UMOD
11integral component of membraneGO:0160219.0PKD2L2, PKD2L1, PKD1L1, PKD1L3, PKHD1, PKD1

Biological processes related to Kidney Disease according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1mesonephric tubule developmentGO:07216410.5PKD1, PKD2
2detection of nodal flowGO:00312710.4PKD1L1, PKD2
3mesonephric duct developmentGO:07217710.4PKD2, PKD1
4positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycGO:03165910.4PKD1, PKD2
5placenta blood vessel developmentGO:06067410.4PKD2, PKD1
6metanephric ascending thin limb developmentGO:07221810.4PKD1, PKD2, UMOD
7cytoplasmic sequestering of transcription factorGO:04299410.3PKD2, PKD1
8spinal cord developmentGO:02151010.3PKD1, PKD2
9detection of chemical stimulus involved in sensory perception of sour tasteGO:00158110.3PKD2L1, PKD1L3
10neural tube developmentGO:02191510.3PKD2, PKD1
11sensory perception of sour tasteGO:05091510.3PKD2L1, PKD1L3
12embryonic placenta developmentGO:00189210.2PKD2, PKD1
13cellular response to acidityGO:07146810.2PKD2L1, PKD1L3, PKD1L2
14determination of left/right symmetryGO:00736810.1PKD2, IFT88
15JAK-STAT cascadeGO:00725910.1PKD1, PKD2
16calcium ion transmembrane transportGO:07058810.1PKDREJ, PKD1, PKD2, PKD2L2
17neuropeptide signaling pathwayGO:00721810.0PKDREJ, PKD1L2, PKD1, PKD1L3
18cation transportGO:0068129.7PKD2L1, PKD1L3
19detection of mechanical stimulusGO:0509829.7PKD2L2, PKD2L1, PKD1L1, PKD2, PKD1, PKDREJ

Molecular functions related to Kidney Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1muscle alpha-actinin bindingGO:05137110.0PKD2L1, PKD2
2carbohydrate bindingGO:0302469.9PKD1L3, PKD1, PKD1L2
3sour taste receptor activityGO:0330409.9PKD2L1, PKD1L3, PKD1L2
4cation channel activityGO:0052619.8PKD1L2, PKD1, PKD1L3, PKD2L1
5cation transmembrane transporter activityGO:0083249.7PKD1L3, PKD2L1
6calcium channel activityGO:0052629.4PKD2L2, PKD2L1, PKD1L1, PKD1L3, PKD1, PKDREJ
7calcium ion bindingGO:0055099.4PKDREJ, PKD1L2, PKD2, PKD2L1, PKD2L2, UMOD

Products for genes affiliated with Kidney Disease

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Sources for Kidney Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet