MCID: KDN018
MIFTS: 58

Kidney Disease malady

Summaries for Kidney Disease

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Kidney Disease, also known as kidney diseases, is related to polycystic kidney disease and polycystic kidney disease, autosomal dominant. An important gene associated with Kidney Disease is PKD2 (polycystic kidney disease 2 (autosomal dominant)). The drugs dopamine and dopamine hydrochloride and the compounds trp-p-2 and la3+ have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and bone, and related mouse phenotype renal/urinary system.

Aliases & Classifications for Kidney Disease

About this section
Sources:
8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
See all sources

Aliases & Descriptions:

kidney disease 8
kidney diseases 60


External Ids:

Disease Ontology8 DOID:557
MeSH34 D007674

Related Diseases for Kidney Disease

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Chronic Kidney Failure family:

Acute Kidney Failure kidney disease
Renal Infectious Disease Ren-Related Kidney Disease
Renal Dysplasia

Diseases related to Kidney Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 435)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic kidney disease31.9PKD1, PKHD1
2polycystic kidney disease, autosomal dominant31.7PKD1, PKD2
3cystic kidney31.4PKD2, PKHD1, UMOD, PKD1
4polycystic kidney disease, autosomal recessive31.2IFT88, PKHD1, PKD2, PKD1
5nephronophthisis30.8PKD1, PKD2, UMOD
6aneurysm disease30.7PKD1, PKD2
7polycystic liver disease30.7PKHD1, PKD2, PKD1, PKD1P6
8congenital hepatic fibrosis30.7PKHD1
9uromodulin-associated kidney disease30.6MCKD2, UMOD
10umod-associated kidney disease30.5MCKD2, UMOD
11polycystic kidney disease, type 230.5PKD1, PKD2
12tuberous sclerosis30.5PKHD1, PKD1, PKD1P6
13primary hyperoxaluria30.2UMOD, PKHD1, PKD2, PKD1
14glomerulocystic kidney disease with hyperuricemia and isosthenuria30.1MCKD2, UMOD
15autosomal dominant disease11.2
16autosomal recessive disease10.8
17hypertension10.8
18proteinuria10.7
19vascular disease10.7
20hepatitis10.6
21chronic kidney failure10.6
22liver disease10.6
23hyperparathyroidism10.5
24medullary cystic kidney disease type 110.5
25autosomal genetic disease10.5
26diabetes mellitus10.5
27chromosomal disease10.5
28obesity10.5
29renal cell carcinoma10.5
30kidney cancer10.5
31hyperphosphatemia10.5
32hyperuricemia10.4
33aortic disease10.4
34peritonitis10.4
35hepatitis a10.4
36kidney hypertrophy10.4
37atherosclerosis10.4
38renal hypertension10.4
39end stage renal failure10.4
40metabolic acidosis10.4
41brain disease10.3
42coronary artery disease10.3
43periodontal disease10.3
44periodontitis10.3
45gout10.3
46renal osteodystrophy10.3
47glomerulonephritis10.3
48type 2 diabetes mellitus10.3
49deficiency anemia10.3
50hepatitis c10.3

Graphical network of the top 20 diseases related to Kidney Disease:



Diseases related to kidney disease

Clinical Features for Kidney Disease

About this section

Drugs & Therapeutics for Kidney Disease

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Kidney Disease

Drug clinical trials:

Search ClinicalTrials for Kidney Disease

Search NIH Clinical Center for Kidney Disease

Search CenterWatch for Kidney Disease

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Kidney Disease

About this section

Anatomical Context for Kidney Disease

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Kidney Disease:

32
Kidney, Liver, Bone, Heart, Endothelial, Brain, Monocytes, Testes, Skin, Lung, Thyroid, Pancreas, Pituitary, Skeletal muscle, Bone marrow, Prostate, Spinal cord, T cells, Pineal, Appendix, Eye, Spleen, Myeloid, Colon

Animal Models for Kidney Disease or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Kidney Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536711.4PKD1, PKD2, PKHD1, PKD1L1, UMOD, IFT88

Publications for Kidney Disease

About this section
Sources:
50PubMed
See all sources

Articles related to Kidney Disease:

(show top 50)    (show all 3349)
idTitleAuthorsYear
1
Chronic kidney disease in patients with renal cell carcinoma. (24359991)
2014
2
Is uremic cardiomyopathy a direct consequence of chronic kidney disease? (24404903)
2014
3
Glibenclamide improves kidney and heart structure and function in the adenine-diet model of chronic kidney disease. (24291534)
2014
4
Nephrotic-range proteinuria is strongly associated with poor blood pressure control in pediatric chronic kidney disease. (24048375)
2013
5
Hyperphosphatemia is associated with overt proteinuria in non-diabetic patients with late-stage chronic kidney disease: a cross-sectional study. (22467089)
2013
6
WHO antiretroviral therapy guidelines 2010 and impact of tenofovir on chronic kidney disease in Vietnamese HIV-infected patients. (24223203)
2013
7
Clinical characteristics and predictors of progression of chronic kidney disease in autosomal dominant polycystic kidney disease: a single center experience. (23085781)
2013
8
Risk of Sudden Cardiac Death in Chronic Kidney Disease. (24256575)
2013
9
Rutin (quercetin rutinoside) induced protein-energy malnutrition in chronic kidney disease, but quercetin acted beneficially. (23876017)
2013
10
A continuous bovine kidney cell line constitutively expressing bovine I+vI^6 integrin has increased susceptibility to foot-and-mouth disease virus. (23515553)
2013
11
Genetics in kidney disease in 2013: Susceptibility genes for renal and urological disorders. (24296626)
2013
12
Statins in chronic kidney disease: what do meta-analyses tell us? (24158229)
2013
13
Pre-eclampsia and the risk of kidney disease. (23727168)
2013
14
Peritransplant management of retained native kidneys in autosomal dominant polycystic kidney disease. (22773241)
2013
15
Chronic kidney disease and the risk of incident gout among middle-aged men: a seven-year prospective observational study. (23982888)
2013
16
New onset diabetes after kidney transplantation in autosomal dominant polycystic kidney disease: a retrospective cohort study. (21854501)
2012
17
Prevention of chronic kidney disease in spina bifida. (21229390)
2012
18
Development of a non-targeted metabolomics method to investigate urine in a rat model of polycystic kidney disease. (22017187)
2012
19
Impact of chronic kidney disease on outcomes after abdominal aortic aneurysm repair. (22857808)
2012
20
The fetal environment: a critical phase that determines future renal outcomes in autosomal dominant polycystic kidney disease. (22499140)
2012
21
Animal models for human polycystic kidney disease. (23095811)
2012
22
Mechanisms and consequences of hypertriglyceridemia and cellular lipid accumulation in chronic kidney disease and metabolic syndrome. (21972098)
2011
23
Altered Hippo signalling in polycystic kidney disease. (21381034)
2011
24
Angiogenic growth factors correlate with disease severity in young patients with autosomal dominant polycystic kidney disease. (20881939)
2011
25
Anesthetic considerations in a patient of autosomal dominant polycystic kidney disease on hemodialysis for emergency cesarean section. (21897520)
2011
26
Is Fibroblast Growth Factor-23 a novel marker for phosphate burden in chronic kidney disease with prognostic implications? (20503017)
2010
27
One year efficacy and safety of lanthanum carbonate for hyperphosphatemia in Japanese chronic kidney disease patients undergoing hemodialysis. (20438515)
2010
28
Effect of paricalcitol and cinacalcet on serum phosphate, FGF-23, and bone in rats with chronic kidney disease. (20200094)
2010
29
Serum adiponectin and cardiovascular risk in chronic kidney disease and kidney transplantation. (20091490)
2010
30
Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus. (19955044)
2010
31
Chronic kidney disease with three cases of oxalate-like nephrosis in Ragdoll cats. (19095478)
2009
32
Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney. (19470766)
2009
33
Recurrent retroperitoneal abscess due to perforated colonic diverticulitis in a patient with polycystic kidney disease. (19299224)
2009
34
Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus. (19288030)
2009
35
Nephrogenic systemic fibrosis in advanced chronic kidney disease: a single hospital's experience in Taiwan. (19059824)
2009
36
Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. (18981227)
2008
37
Chromophobe renal cell carcinoma and 'capsulomas' with acquired cystic disease of the kidney in a long-term hemodialysis patient. (18489645)
2008
38
A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. (18094682)
2008
39
Influence of VEGF polymorphism on progression of autosomal dominant polycystic kidney disease. (19060482)
2008
40
Osteopontin (OPN), PDGF-BB (platelet-derived growth factor) and BMP-7 (bone morphogenetic protein) as markers of atherogenesis in children with chronic kidney disease (CKD) treated conservatively--preliminary results]. (18924496)
2008
41
PKHD1 gene silencing may cause cell abnormal proliferation through modulation of intracellular calcium in autosomal recessive polycystic kidney disease. (17669261)
2007
42
Plasminogen activator inhibitor-1 in chronic kidney disease: evidence and mechanisms of action. (17035608)
2006
43
Risks of chronic metabolic acidosis in patients with chronic kidney disease. (15882309)
2005
44
Changes in cardiac troponin T measurements are associated with adverse cardiac events in patients with chronic kidney disease. (16032613)
2005
45
An unexpected cystic kidney and pancreas disease. (12032212)
2002
46
AT(1)-receptor blockade and the kidney: importance of non-ACE pathways in health and disease. (12140730)
2002
47
Confirmation of a gene locus for medullary cystic kidney disease (MCKD2) on chromosome 16p12. (11576337)
2001
48
Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome. (10880400)
2000
49
A spectrum of mutations in the second gene for autosomal dominant polycystic kidney disease (PKD2). (9326320)
1997
50
A role for CFTR in human autosomal dominant polycystic kidney disease. (8772467)
1996

Genetic Variations for Kidney Disease

About this section

Expression for genes affiliated with Kidney Disease

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Kidney Disease

Search GEO for disease gene expression data for Kidney Disease.

Pathways for genes affiliated with Kidney Disease

About this section

Compounds for genes affiliated with Kidney Disease

About this section
Sources:
44Novoseek, 28IUPHAR
See all sources

Compounds related to Kidney Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1trp-p-24410.8PKD1, PKD2
2la3+2810.8PKD2, PKD2L1
3cai2+2810.7PKD2, PKD2L1
4gd3+2810.5PKD2, PKD2L1

GO Terms for genes affiliated with Kidney Disease

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Kidney Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ciliumGO:00592911.2PKD1, PKD2, PKD1L1, IFT88
2motile primary ciliumGO:03151211.1PKD1, PKD2, IFT88
3microtubule basal bodyGO:00593210.9PKD2, PKHD1, IFT88
4polycystin complexGO:00213310.8PKD2, PKD1
5primary ciliumGO:07237210.8PKHD1, UMOD
6mitotic spindleGO:07268610.5PKD2, PKHD1

Biological processes related to Kidney Disease according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1detection of mechanical stimulusGO:05098211.8PKD2L2, PKDREJ, PKD1, PKD2, PKD2L1, PKD1L1
2calcium ion transmembrane transportGO:07058811.8PKD1L1, PKD2L1, PKD2, PKD1, PKDREJ, PKD2L2
3neuropeptide signaling pathwayGO:00721811.4PKDREJ, PKD1, PKD1L2, PKD1L3
4metanephric ascending thin limb developmentGO:07221811.3UMOD, PKD2, PKD1
5detection of nodal flowGO:00312711.1PKD1L1, PKD2
6detection of chemical stimulus involved in sensory perception of sour tasteGO:00158111.1PKD1L3, PKD2L1
7mesonephric tubule developmentGO:07216411.1PKD2, PKD1
8mesonephric duct developmentGO:07217711.0PKD1, PKD2
9cellular response to acidityGO:07146811.0PKD2L1, PKD1L3
10positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycGO:03165911.0PKD2, PKD1
11placenta blood vessel developmentGO:06067411.0PKD1, PKD2
12cytoplasmic sequestering of transcription factorGO:04299410.9PKD1, PKD2
13sodium ion transmembrane transportGO:03572510.9PKD2L1, PKD2
14spinal cord developmentGO:02151010.9PKD1, PKD2
15cation transportGO:00681210.8PKD2L1, PKD1L3
16JAK-STAT cascadeGO:00725910.8PKD1, PKD2
17neural tube developmentGO:02191510.7PKD2, PKD1
18embryonic placenta developmentGO:00189210.5PKD1, PKD2

Molecular functions related to Kidney Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium channel activityGO:00526211.4PKD2L2, PKDREJ, PKD1, PKD2L1, PKD1L1
2calcium ion bindingGO:00550911.3UMOD, PKD1L2, PKD2L1, PKD2, PKDREJ, PKD2L2
3cation channel activityGO:00526111.0PKD1L3, PKD2L1, PKD1
4carbohydrate bindingGO:03024611.0PKD1, PKD1L2, PKD1L3
5sour taste receptor activityGO:03304010.8PKD2L1, PKD1L3
6cation transmembrane transporter activityGO:00832410.5PKD2L1, PKD1L3

Products for genes affiliated with Kidney Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Kidney Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet