MCID: KDN013
MIFTS: 25

Kidney Hypertrophy

Categories: Nephrological diseases

Aliases & Classifications for Kidney Hypertrophy

MalaCards integrated aliases for Kidney Hypertrophy:

Name: Kidney Hypertrophy 12 14
Hypertrophy of Kidney 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9622
ICD10 32 N28.81
ICD9CM 34 593.1
NCIt 46 C122991
SNOMED-CT 64 197800004 88531004
UMLS 69 C0156259

Summaries for Kidney Hypertrophy

MalaCards based summary : Kidney Hypertrophy, also known as hypertrophy of kidney, is related to sialolithiasis and analbuminemia. An important gene associated with Kidney Hypertrophy is ALB (Albumin), and among its related pathways/superpathways are Primary Focal Segmental Glomerulosclerosis FSGS and Nephrin/Neph1 signaling in the kidney podocyte. Affiliated tissues include kidney.

Related Diseases for Kidney Hypertrophy

Diseases related to Kidney Hypertrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 sialolithiasis 10.2 ALB CTGF
2 analbuminemia 10.2 ALB NPHS1
3 urinary tract obstruction 10.1 ALB CTGF
4 membranoproliferative glomerulonephritis 10.1 ALB NPHS1
5 retinal vascular disease 10.0 ALB CTGF
6 familial idiopathic steroid-resistant nephrotic syndrome with minimal changes 10.0 NPHS1 NPHS2
7 atrial septal defect 3 10.0 NPHS1 NPHS2
8 hypoparathyroidism, sensorineural deafness, and renal disease 10.0 NPHS1 NPHS2
9 nephrosclerosis 10.0 CTGF NPHS2
10 biliary atresia 10.0 ALB CTGF
11 familial nephrotic syndrome 10.0 NPHS1 NPHS2
12 nephrotic syndrome, type 1 10.0 NPHS1 NPHS2
13 focal segmental glomerulosclerosis 1 10.0 NPHS1 NPHS2
14 denys-drash syndrome 9.9 NPHS1 NPHS2
15 microvascular complications of diabetes 3 9.9 ALB CTGF NPHS1
16 diffuse mesangial sclerosis 9.9 NPHS1 NPHS2
17 trypanosomiasis 9.9 ALB ODC1
18 galloway-mowat syndrome 9.8 NPHS1 NPHS2
19 frasier syndrome 9.8 NPHS1 NPHS2
20 lipoid nephrosis 9.8 ALB NPHS1 NPHS2
21 membranous nephropathy 9.8 ALB NPHS1 NPHS2
22 end stage renal failure 9.8 ALB NPHS1 NPHS2
23 iga glomerulonephritis 9.8 ALB NPHS1 NPHS2
24 chronic kidney failure 9.8 ALB NPHS1 NPHS2
25 nephrotic syndrome 9.8 ALB NPHS1 NPHS2
26 glomerulonephritis 9.8 ALB NPHS1 NPHS2
27 blood group, i system 9.7
28 focal segmental glomerulosclerosis 9.7 ALB NPHS1 NPHS2
29 kidney disease 9.7 ALB NPHS1 NPHS2
30 aging 9.6
31 chronic pyelonephritis 9.6
32 pyelonephritis 9.6
33 bronchopneumonia 9.6
34 arteriosclerosis 9.6
35 uremia 9.6
36 urinary system disease 9.5 ALB CTGF NPHS1 NPHS2

Comorbidity relations with Kidney Hypertrophy via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Kidney Hypertrophy:



Diseases related to Kidney Hypertrophy

Symptoms & Phenotypes for Kidney Hypertrophy

Drugs & Therapeutics for Kidney Hypertrophy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Matrix Metalloproteinases and Diabetic Nephropathy Completed NCT00067886

Search NIH Clinical Center for Kidney Hypertrophy

Genetic Tests for Kidney Hypertrophy

Anatomical Context for Kidney Hypertrophy

MalaCards organs/tissues related to Kidney Hypertrophy:

38
Kidney

Publications for Kidney Hypertrophy

Articles related to Kidney Hypertrophy:

(show all 24)
# Title Authors Year
1
Ureteric entrapment in sacroiliac joint causing hydroureter and ipsilateral kidney hypertrophy. ( 29222673 )
2017
2
Correlation of whole kidney hypertrophy with glomerular over-filtration in live, gender-mismatched renal transplant allografts. ( 27576505 )
2016
3
Stimulation of Sigma-1 receptor by dehydroepiandrosterone ameliorates hypertension-induced kidney hypertrophy in ovariectomized rats. ( 20404054 )
2010
4
Development of hypertension and kidney hypertrophy in transgenic mice overexpressing ARAP1 gene in the kidney. ( 16801480 )
2006
5
The juvenile three-spined stickleback (Gasterosteus aculeatus L.) as a model organism for endocrine disruption II--kidney hypertrophy, vitellogenin and spiggin induction. ( 15588642 )
2004
6
Effect of ammonium chloride and dietary phosphorus in the azotaemic rat. Part II--Kidney hypertrophy and calcium deposition. ( 15161952 )
2004
7
Renin-angiotensin system blockade prevents the increase in plasma transforming growth factor beta 1, and reduces proteinuria and kidney hypertrophy in the streptozotocin-diabetic rat. ( 15526251 )
2004
8
Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. ( 8603776 )
1996
9
An evaluation of the role of polyamines in different models of kidney hypertrophy in mice. ( 7474658 )
1995
10
Inhibition of renal ornithine decarboxylase activity fails to reduce kidney size and urinary albumin excretion in diabetic rats with manifest kidney hypertrophy. ( 7796931 )
1995
11
Renal proteinases and kidney hypertrophy in experimental diabetes. ( 7926340 )
1994
12
Inhibition of renal ornithine decarboxylase activity prevents kidney hypertrophy in experimental diabetes. ( 8447376 )
1993
13
Morphometric analysis of kidney hypertrophy in rats after chronic potassium depletion. ( 1566879 )
1992
14
Transient increase in renal insulin-like growth factor binding proteins during initial kidney hypertrophy in experimental diabetes in rats. ( 1377139 )
1992
15
Vasopressin-dependent kidney hypertrophy: role of urinary concentration in protein-induced hypertrophy and in the progression of chronic renal failure. ( 2042645 )
1991
16
Characterization of beta-adrenergic receptor subtypes in androgen-induced mouse kidney hypertrophy using a new high-affinity ligand, [125I]iodocyanopindolol. ( 6299377 )
1983
17
Increased beta-adrenergic receptor complement in androgen-induced mouse kidney hypertrophy. ( 6269651 )
1981
18
Regulation of compensatory kidney hypertrophy by its own products. ( 894611 )
1977
19
The influence of salt intake on glomerular count in compensatory kidney hypertrophy in rats of different ages. ( 954972 )
1976
20
Ornithine decarboxylase activity and polyamine synthesis during kidney hypertrophy. ( 4119904 )
1972
21
Immunochemical studies on kidney hypertrophy of the rat. ( 13954727 )
1962
22
WEEKLY clinicopathological exercises: chronic pyelonephritis severe (with uremia); atrophy of the right kidney, hypertrophy of left; bronchopneumonia; aortic arteriosclerosis, severe, ascending arch, with short localized dissection; calcareous aortic stenosis. ( 14863577 )
1951
23
Kidney hypertrophy in B complex deficiency. ( 21024173 )
1946
24
THE PRODUCTION OF HYPERTENSION BY THE PREVENTION OF KIDNEY HYPERTROPHY: (Preliminary Report). ( 20321520 )
1939

Variations for Kidney Hypertrophy

Expression for Kidney Hypertrophy

Search GEO for disease gene expression data for Kidney Hypertrophy.

Pathways for Kidney Hypertrophy

Pathways related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.67 NPHS1 NPHS2 PODXL
2 10.37 NPHS1 NPHS2

GO Terms for Kidney Hypertrophy

Cellular components related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 slit diaphragm GO:0036057 8.8 NPHS1 NPHS2 PODXL

Biological processes related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 excretion GO:0007588 8.96 NPHS1 NPHS2
2 glomerular visceral epithelial cell development GO:0072015 8.62 NPHS1 PODXL

Molecular functions related to Kidney Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.28 ALB ARAP1 CTGF NHEJ1 NPHS1 NPHS2

Sources for Kidney Hypertrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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