MCID: KDN006
MIFTS: 27

Kidney Papillary Necrosis

Categories: Nephrological diseases

Aliases & Classifications for Kidney Papillary Necrosis

MalaCards integrated aliases for Kidney Papillary Necrosis:

Name: Kidney Papillary Necrosis 12 41 14 69
Necrotizing Renal Papillitis 12
Renal Papillitis Necrotizing 12
Papillary Necrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2981
MeSH 41 D007681
SNOMED-CT 64 197651008 90241004
UMLS 69 C0022667

Summaries for Kidney Papillary Necrosis

MalaCards based summary : Kidney Papillary Necrosis, also known as necrotizing renal papillitis, is related to anuria and interstitial nephritis. An important gene associated with Kidney Papillary Necrosis is LYZ (Lysozyme), and among its related pathways/superpathways are Celecoxib Pathway, Pharmacodynamics and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. Affiliated tissues include kidney, and related phenotypes are homeostasis/metabolism and mortality/aging

Wikipedia : 72 Renal papillary necrosis is a form of nephropathy involving the necrosis of the renal papilla. Lesions... more...

Related Diseases for Kidney Papillary Necrosis

Diseases related to Kidney Papillary Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 anuria 29.6 ALB REN
2 interstitial nephritis 29.1 ALB REN
3 vesicoureteral reflux 1 10.0 MGEA5 REN
4 antenatal bartter syndrome 10.0 PTGS1 REN
5 diffuse glomerulonephritis 10.0 ALB LYZ
6 ulcerative stomatitis 10.0 ALB LYZ
7 benign essential hypertension 9.9 ALB REN
8 orthostatic proteinuria 9.9 ALB REN
9 hepatorenal syndrome 9.9 ALB REN
10 waterhouse-friderichsen syndrome 9.9
11 renal hypertension 9.9 ALB REN
12 pyelitis 9.9 LYZ MGEA5 REN
13 renal tuberculosis 9.9 LYZ MGEA5 REN
14 hepatic vascular disease 9.9 ALB REN
15 pyuria 9.9 ALB MGEA5
16 acute kidney failure 9.8 ALB REN
17 acute kidney tubular necrosis 9.8 ALB MGEA5
18 urinary tract obstruction 9.8 ALB REN
19 ovarian hyperstimulation syndrome 9.8 ALB REN
20 ureteral obstruction 9.8
21 obstructive jaundice 9.8 ALB REN
22 iga glomerulonephritis 9.8 ALB REN
23 meningitis 9.8 ALB LYZ
24 glucose metabolism disease 9.8 ALB REN
25 arteries, anomalies of 9.7 ALB REN
26 hydrops, lactic acidosis, and sideroblastic anemia 9.7 ALB PTGS1
27 medullary sponge kidney 9.7
28 acquired metabolic disease 9.7 ALB REN
29 diabetes mellitus 9.6
30 glomerulonephritis 9.6
31 hydronephrosis 9.6
32 pyelonephritis 9.6
33 leptospirosis 9.6
34 gastroenteritis 9.6
35 hemoglobinopathy 9.6
36 protein c deficiency 9.6
37 rapidly progressive glomerulonephritis 9.6
38 autosomal dominant polycystic kidney disease 9.6 ALB REN
39 chronic kidney failure 9.4 ALB REN
40 urinary system disease 9.3 ALB LYZ MGEA5 REN
41 myocardial infarction 9.2 ALB PTGS1 REN

Graphical network of the top 20 diseases related to Kidney Papillary Necrosis:



Diseases related to Kidney Papillary Necrosis

Symptoms & Phenotypes for Kidney Papillary Necrosis

MGI Mouse Phenotypes related to Kidney Papillary Necrosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 REN ALB LYZ NFAT5 PTGIR PTGS1
2 mortality/aging MP:0010768 9.8 ALB LYZ MGEA5 NFAT5 PTGIR PTGS1
3 cardiovascular system MP:0005385 9.77 LYZ NFAT5 PTGIR PTGS1 REN
4 muscle MP:0005369 9.46 ALB NFAT5 PTGS1 REN
5 neoplasm MP:0002006 9.26 ALB LYZ PTGIR PTGS1
6 renal/urinary system MP:0005367 9.02 ALB LYZ NFAT5 PTGS1 REN

Drugs & Therapeutics for Kidney Papillary Necrosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Regional and Long Term Outcomes of Acute Kidney Injury in England From 2000 to 2015 - A National Database Study Completed NCT02675296

Search NIH Clinical Center for Kidney Papillary Necrosis

Cochrane evidence based reviews: kidney papillary necrosis

Genetic Tests for Kidney Papillary Necrosis

Anatomical Context for Kidney Papillary Necrosis

MalaCards organs/tissues related to Kidney Papillary Necrosis:

38
Kidney

Publications for Kidney Papillary Necrosis

Articles related to Kidney Papillary Necrosis:

# Title Authors Year
1
Necrotizing renal papillitis review and report of a case treated by nephrectomy and complicated by Waterhouse-Friderichsen syndrome. ( 13512121 )
1958

Variations for Kidney Papillary Necrosis

Expression for Kidney Papillary Necrosis

Search GEO for disease gene expression data for Kidney Papillary Necrosis.

Pathways for Kidney Papillary Necrosis

Pathways related to Kidney Papillary Necrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.02 PTGIR PTGS1
2 10.86 PTGIR PTGS1
3 10.43 PTGIR PTGS1
4 10.07 PTGIR PTGS1

GO Terms for Kidney Papillary Necrosis

Biological processes related to Kidney Papillary Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.16 ALB PTGS1
2 regulation of blood pressure GO:0008217 8.96 PTGS1 REN
3 retina homeostasis GO:0001895 8.62 ALB LYZ

Molecular functions related to Kidney Papillary Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity, acting on glycosyl bonds GO:0016798 8.62 LYZ MGEA5

Sources for Kidney Papillary Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....