MCID: KDN019
MIFTS: 31

Kidney Sarcoma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Kidney Sarcoma

MalaCards integrated aliases for Kidney Sarcoma:

Name: Kidney Sarcoma 12 14
Sarcoma of Kidney 12 69
Renal Sarcoma 12 28

Classifications:



External Ids:

Disease Ontology 12 DOID:4242
NCIt 46 C4525
SNOMED-CT 64 254918001
UMLS 69 C0346251

Summaries for Kidney Sarcoma

Disease Ontology : 12 A kidney cancer that is located in the kidney's connective tissue.

MalaCards based summary : Kidney Sarcoma, also known as sarcoma of kidney, is related to kidney clear cell sarcoma and kidney osteogenic sarcoma. An important gene associated with Kidney Sarcoma is DICER1 (Dicer 1, Ribonuclease III), and among its related pathways/superpathways is Tyrosine metabolism. The drugs Carboplatin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include the kidney's connective tissue, kidney and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Kidney Sarcoma

Diseases related to Kidney Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 kidney clear cell sarcoma 31.0 TH WT1
2 kidney osteogenic sarcoma 10.8
3 cystic nephroma 9.9 DICER1 WT1
4 dysgerminoma of ovary 9.9 DICER1 WT1
5 botryoid rhabdomyosarcoma 9.9 DICER1 WT1
6 sex cord-gonadal stromal tumor 9.8 DICER1 WT1
7 rhabdomyosarcoma 2 9.7 TH WT1
8 sarcoma 9.6
9 beckwith-wiedemann syndrome 9.5 TH WT1

Graphical network of the top 20 diseases related to Kidney Sarcoma:



Diseases related to Kidney Sarcoma

Symptoms & Phenotypes for Kidney Sarcoma

GenomeRNAi Phenotypes related to Kidney Sarcoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.36 DICER1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.36 DICER1 HPD WT1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.36 DICER1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.36 HPD
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.36 HPD
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.36 HPD
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.36 DICER1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.36 HPD
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.36 HPD
10 Decreased melanin production GR00056-A 8.96 HPD SLC17A5

MGI Mouse Phenotypes related to Kidney Sarcoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.43 DICER1 HPD NECTIN1 SLC17A5 TH WT1
2 vision/eye MP:0005391 8.92 DICER1 NECTIN1 SLC17A5 TH

Drugs & Therapeutics for Kidney Sarcoma

Drugs for Kidney Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 84)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
2
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
3
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 457193 2019
4
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
5
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
6
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
7
Lenograstim Approved, Investigational Phase 3,Phase 2 135968-09-1
8
Sulfamethoxazole Approved Phase 3 723-46-6 5329
9
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
10
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
11
Methylphenidate Approved, Investigational Phase 3 20748-11-2, 113-45-1 4158
12
Morphine Approved, Investigational Phase 3 57-27-2 5288826
13
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
14
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1 51-75-2 4033
15
Cyproheptadine Approved Phase 3 129-03-3 2913
16
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
17
Doxil Approved June 1999 Phase 3,Phase 2 31703
18 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
19 Alkylating Agents Phase 3,Phase 2,Phase 1
20 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
21 Antibiotics, Antitubercular Phase 3,Phase 2
22 Anti-Infective Agents Phase 3,Phase 2,Phase 1
23 Antimitotic Agents Phase 3,Phase 2,Phase 1
24 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
25 Antirheumatic Agents Phase 3,Phase 2
26 Etoposide phosphate Phase 3,Phase 2,Phase 1
27 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
28 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
29 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
30 Adjuvants, Immunologic Phase 3,Phase 2
31 Liver Extracts Phase 3,Phase 1,Phase 2
32 Adjuvants, Anesthesia Phase 3
33 Analgesics Phase 3
34 Analgesics, Opioid Phase 3
35 Anesthetics Phase 3
36 Anesthetics, General Phase 3
37 Anesthetics, Intravenous Phase 3
38 Central Nervous System Depressants Phase 3
39 Narcotics Phase 3
40 Peripheral Nervous System Agents Phase 3
41 Epoetin alfa Phase 3 113427-24-0
42 Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
43 Anti-Allergic Agents Phase 3
44 Antipruritics Phase 3
45 Dermatologic Agents Phase 3
46 Gastrointestinal Agents Phase 3
47 Histamine Antagonists Phase 3
48 Histamine H1 Antagonists Phase 3
49
Histamine Phosphate Phase 3 51-74-1 65513
50 Neurotransmitter Agents Phase 3

Interventional clinical trials:

(show all 25)

# Name Status NCT ID Phase Drugs
1 Chemotherapy With or Without Surgery, Radiation Therapy, or Stem Cell Transplantation in Treating Young Patients With Kidney Tumors Completed NCT00002610 Phase 3 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;vincristine sulfate
2 Combination Chemotherapy Alone or With Radiation Therapy in Treating Children With Kidney Cancer Completed NCT00002611 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;vincristine sulfate
3 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
4 E-MOSAIC Electronic Tool to Monitor Symptoms Completed NCT00477919 Phase 3
5 Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
6 Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
7 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
8 Chemotherapy Followed by Surgery and Radiation Therapy With or Without Stem Cell Transplant in Treating Patients With Relapsed or Refractory Wilms' Tumor or Clear Cell Sarcoma of the Kidney Unknown status NCT00025103 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;melphalan;vincristine sulfate
9 Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors Completed NCT00335556 Phase 2 Doxorubicin Hydrochloride;Irinotecan Hydrochloride;Cyclophosphamide;Etoposide;Carboplatin;Vincristine Sulfate
10 Therapeutic Angiotensin-(1-7) in Treating Patients With Metastatic Sarcoma That Cannot Be Removed By Surgery Completed NCT01553539 Phase 2 therapeutic angiotensin-(1-7)
11 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
12 Chemotherapy in Treating Patients With Solid Tumors Completed NCT00003103 Phase 1, Phase 2 docetaxel
13 High-dose ICE With Amifostine Completed NCT00003657 Phase 2 Amifostine;Carboplatin;Etoposide;Ifosfamide
14 Sunitinib Malate With or Without Gemcitabine Hydrochloride in Treating Patients With Advanced Kidney Cancer That Cannot Be Removed By Surgery Active, not recruiting NCT01164228 Phase 2 gemcitabine hydrochloride;sunitinib malate
15 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
16 Dalteparin and Sunitinib Malate as First-Line Therapy in Treating Patients With Kidney Cancer That is Metastatic or Cannot Be Removed by Surgery Completed NCT01061411 Phase 1 Dalteparin;Sunitinib Malate
17 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
18 Study of Information Received About Fertility and Infertility in Patients Who Have Finished Treatment for Cancer Unknown status NCT01295463
19 Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom Unknown status NCT00757614
20 Biomarkers in Tissue Samples From Patients With High-Risk Wilms Tumor Completed NCT01118078
21 Early Intervention vs. Standard Palliative Care in Improving End-of-Life Care in Advanced Cancer Patients Completed NCT00253383
22 International PPB Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158
23 Study of Kidney Tumors in Younger Patients Recruiting NCT00898365
24 Studying Biomarkers in Samples From Younger Patients With Kidney Cancer Withdrawn NCT01642095
25 Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Advanced or Refractory Solid Tumors Withdrawn NCT00499291 paclitaxel albumin-stabilized nanoparticle formulation

Search NIH Clinical Center for Kidney Sarcoma

Genetic Tests for Kidney Sarcoma

Genetic tests related to Kidney Sarcoma:

# Genetic test Affiliating Genes
1 Renal Sarcoma 28

Anatomical Context for Kidney Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Kidney Sarcoma:

18
The Kidney'S Connective Tissue

MalaCards organs/tissues related to Kidney Sarcoma:

38
Kidney, Lung, Liver, T Cells

Publications for Kidney Sarcoma

Articles related to Kidney Sarcoma:

# Title Authors Year
1
Transfer of IFNgamma-depleted CD4(+) T cells together with CD8(+) T cells leads to rejection of murine kidney sarcoma in mice. ( 10925361 )
2000

Variations for Kidney Sarcoma

Expression for Kidney Sarcoma

Search GEO for disease gene expression data for Kidney Sarcoma.

Pathways for Kidney Sarcoma

Pathways related to Kidney Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.5 HPD TH

GO Terms for Kidney Sarcoma

Cellular components related to Kidney Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.8 DICER1 NECTIN1 TH

Biological processes related to Kidney Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aromatic amino acid family metabolic process GO:0009072 8.62 HPD TH

Sources for Kidney Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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