MCID: KDN019
MIFTS: 31

Kidney Sarcoma malady

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Kidney Sarcoma

Aliases & Descriptions for Kidney Sarcoma:

Name: Kidney Sarcoma 12 14
Sarcoma of Kidney 12 29 69
Renal Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4242
NCIt 47 C4525
SNOMED-CT 64 254918001
UMLS 69 C0346251

Summaries for Kidney Sarcoma

Disease Ontology : 12 A kidney cancer that is located in the kidney's connective tissue.

MalaCards based summary : Kidney Sarcoma, also known as sarcoma of kidney, is related to kidney clear cell sarcoma and kidney osteogenic sarcoma. An important gene associated with Kidney Sarcoma is DICER1 (Dicer 1, Ribonuclease III), and among its related pathways/superpathways is TGF-beta Signaling Pathways. The drugs Busulfan and Dactinomycin have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and the kidney's connective tissue, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and homeostasis/metabolism

Related Diseases for Kidney Sarcoma

Graphical network of the top 20 diseases related to Kidney Sarcoma:



Diseases related to Kidney Sarcoma

Symptoms & Phenotypes for Kidney Sarcoma

GenomeRNAi Phenotypes related to Kidney Sarcoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.36 DICER1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.36 WT1 DICER1 HPD
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.36 DICER1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.36 HPD
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.36 HPD
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.36 HPD
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.36 DICER1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.36 HPD
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.36 HPD
10 Decreased melanin production GR00056-A 8.96 HPD SLC17A5

MGI Mouse Phenotypes related to Kidney Sarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.1 CREB3L1 DICER1 HPD MYOD1 SLC17A5 WT1

Drugs & Therapeutics for Kidney Sarcoma

Drugs for Kidney Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 268)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Busulfan Approved, Investigational Phase 3,Phase 2,Phase 1 55-98-1 2478
2
Dactinomycin Approved Phase 3,Phase 2 50-76-0 2019 457193
3
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
4
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
5
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
6
Mechlorethamine Approved Phase 3,Phase 1,Phase 2 51-75-2 4033
7
Melphalan Approved Phase 3,Phase 2,Phase 1 148-82-3 4053 460612
8
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
9
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
10
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
11
Mesna Approved Phase 3,Phase 1,Phase 2 3375-50-6 598
12
Sorafenib Approved, Investigational Phase 3,Phase 1,Phase 2 284461-73-0 216239 406563
13
Lenograstim Approved Phase 3,Phase 2,Phase 1 135968-09-1
14
Sulfamethoxazole Approved Phase 3 723-46-6 5329
15
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
16
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
17
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
18
Morphine Approved, Investigational Phase 3,Phase 1 57-27-2 5288826
19
Dacarbazine Approved, Investigational Phase 3,Phase 2,Phase 1 4342-03-4 5351166
20
Gemcitabine Approved Phase 3,Phase 2,Phase 1 95058-81-4 60750
21
Bortezomib Approved, Investigational Phase 3,Phase 1 179324-69-7 387447 93860
22
Topotecan Approved, Investigational Phase 3,Phase 2,Phase 1 119413-54-6, 123948-87-8 60700
23
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
24
Methotrexate Approved Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
25
Vinblastine Approved Phase 3,Phase 1 865-21-4 13342 241903
26
Asparaginase Approved Phase 3 9015-68-3
27
Cytarabine Approved, Investigational Phase 3 147-94-4 6253
28
Daunorubicin Approved Phase 3 20830-81-3 30323
29
Mitoxantrone Approved, Investigational Phase 3 65271-80-9 4212
30
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
31
Cyproheptadine Approved Phase 3 129-03-3 2913
32
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
33
Zoledronic acid Approved Phase 3 118072-93-8 68740
34
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 1,Phase 2 59-30-3 6037
35
Niacin Approved, Investigational, Nutraceutical Phase 3,Phase 1,Phase 2 59-67-6 938
36
Nicotinamide Approved, Nutraceutical Phase 3,Phase 1,Phase 2 98-92-0 936
37
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1 58-05-9 54575, 6560146 143
38
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
39
Docetaxel Approved May 1996, Investigational Phase 3,Phase 1,Phase 2 114977-28-5 148124 9877265
40 Alkylating Agents Phase 3,Phase 2,Phase 1,Early Phase 1
41 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Early Phase 1
42 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
43 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Early Phase 1
44 Antimitotic Agents Phase 3,Phase 2,Phase 1
45 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1,Early Phase 1
46 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
47 Etoposide phosphate Phase 3,Phase 2,Phase 1
48 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Early Phase 1
49 Isophosphamide mustard Phase 3,Phase 1,Phase 2
50 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 234)
id Name Status NCT ID Phase
1 Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma Unknown status NCT00020566 Phase 3
2 Imatinib Mesylate or Observation Only in Treating Patients Who Have Undergone Surgery for Localized Gastrointestinal Stromal Tumor Unknown status NCT00103168 Phase 3
3 Chemotherapy With or Without Surgery, Radiation Therapy, or Stem Cell Transplantation in Treating Young Patients With Kidney Tumors Completed NCT00002610 Phase 3
4 Combination Chemotherapy Alone or With Radiation Therapy in Treating Children With Kidney Cancer Completed NCT00002611 Phase 3
5 Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00002641 Phase 3
6 Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma Completed NCT00002764 Phase 3
7 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
8 E-MOSAIC Electronic Tool to Monitor Symptoms Completed NCT00477919 Phase 3
9 A Trial of TH-302 in Combination With Doxorubicin Versus Doxorubicin Alone to Treat Patients With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma Completed NCT01440088 Phase 3
10 Phase 3 Study to Treat Patients With Soft Tissue Sarcomas Completed NCT02049905 Phase 3
11 Glutamic Acid in Reducing Nerve Damage Caused by Vincristine in Young Patients With Cancer Completed NCT00369564 Phase 3
12 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3
13 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
14 NBTXR3 Crystalline Nanoparticles and Radiation Therapy in Treating and Randomized Patients in Two Arms With Soft Tissue Sarcoma of the Extremity and Trunk Wall Recruiting NCT02379845 Phase 2, Phase 3
15 Observation Versus Post-surgery Radiotherapy After Complete Exeresis in Soft Tissues Members Sarcoma Recruiting NCT00870701 Phase 3
16 Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma Recruiting NCT02306161 Phase 3
17 Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Recruiting NCT01371981 Phase 3
18 Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma Active, not recruiting NCT01231906 Phase 3
19 I-MVAC +/- Panitumumab as First-line Treatment of Advanced Urothelial Carcinoma Without H-Ras Nor K-Ras Mutations Active, not recruiting NCT02818725 Phase 3
20 Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer Active, not recruiting NCT01987596 Phase 3
21 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
22 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3
23 Combined Chemotherapy With or Without Zoledronic Acid for Patients With Osteosarcoma Terminated NCT00470223 Phase 3
24 Chemotherapy Followed by Surgery and Radiation Therapy With or Without Stem Cell Transplant in Treating Patients With Relapsed or Refractory Wilms' Tumor or Clear Cell Sarcoma of the Kidney Unknown status NCT00025103 Phase 2
25 Phase I-II Trial of Sorafenib in Combination With Ifosfamide in Soft Tissue Sarcoma Unknown status NCT00541840 Phase 1, Phase 2
26 Dendritic Cell Vaccination for Patients With Solid Tumors Unknown status NCT01291420 Phase 1, Phase 2
27 FLO +/- Pazopanib as First-line Treatment in Advanced Gastric Cancer Unknown status NCT01503372 Phase 2
28 Sorafenib and Paclitaxel in Treating Patients With Metastatic Breast Cancer Unknown status NCT00622466 Phase 2
29 Light-Emitting Diode Therapy in Preventing Mucositis in Children Receiving Chemotherapy With or Without Radiation Therapy Before Bone Marrow Transplantation Unknown status NCT00036712 Phase 2
30 Umbilical Cord Blood for Stem Cell Transplantation in Treating Young Patients With Malignant or Nonmalignant Diseases Unknown status NCT00084695 Phase 2
31 Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors Completed NCT00335556 Phase 2
32 Therapeutic Angiotensin-(1-7) in Treating Patients With Metastatic Sarcoma That Cannot Be Removed By Surgery Completed NCT01553539 Phase 2
33 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2
34 High-dose ICE With Amifostine Completed NCT00003657 Phase 2
35 Chemotherapy in Treating Patients With Solid Tumors Completed NCT00003103 Phase 1, Phase 2
36 Radiation Therapy in Treating Patients With Newly Diagnosed Brain Metastases From Kidney Cancer, Melanoma, or Sarcoma Completed NCT00003308 Phase 2
37 Combination Chemotherapy and Radiation Therapy in Treating Patients With Peripheral Neuroectodermal Tumors, Ewing's Sarcoma, Wilms' Tumor, or Bone Cancer Completed NCT00002466 Phase 2
38 Phase 2 Study in Patients With MiT Tumors Completed NCT00557609 Phase 2
39 Sorafenib and Dacarbazine in Soft Tissue Sarcoma Completed NCT00837148 Phase 2
40 Trial of Neoadjuvant Conformal Radiotherapy Plus Sorafenib for Patients With Soft Tissue Sarcoma of the Extremity and Body Wall Completed NCT00864032 Phase 1, Phase 2
41 Pazopanib in Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib Completed NCT01524848 Phase 2
42 Neoadjuvant and Adjuvant Chemotherapy in High-risk Soft Tissue Sarcoma Completed NCT01382030 Phase 2
43 Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors Completed NCT00024258 Phase 2
44 Temozolomide Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Malignant Glioma or Recurrent CNS or Other Solid Tumors Completed NCT00005952 Phase 1, Phase 2
45 Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer Completed NCT00002515 Phase 2
46 Cixutumumab in Treating Patients With Relapsed or Refractory Solid Tumors Completed NCT00831844 Phase 2
47 Glutamine in Treating Neuropathy Caused by Vincristine in Young Patients With Lymphoma, Leukemia, or Solid Tumors Completed NCT00365768 Phase 2
48 Pazopanib as Single Agent in Advanced NETs Completed NCT01280201 Phase 2
49 Study of F-Fluorodeoxyglucose (FluGlucoScan) in Patients With Known or Suspected Cancers of Low Incidence Completed NCT00123773 Phase 2
50 Paclitaxel in Treating Patients With Locally Advanced or Metastatic Soft Tissue Angiosarcoma or Lymphangiosarcoma That Cannot Be Removed By Surgery Completed NCT00217607 Phase 2

Search NIH Clinical Center for Kidney Sarcoma

Genetic Tests for Kidney Sarcoma

Genetic tests related to Kidney Sarcoma:

id Genetic test Affiliating Genes
1 Renal Sarcoma 29

Anatomical Context for Kidney Sarcoma

MalaCards organs/tissues related to Kidney Sarcoma:

39
Kidney, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Kidney Sarcoma:

18
The Kidney'S Connective Tissue

Publications for Kidney Sarcoma

Articles related to Kidney Sarcoma:

id Title Authors Year
1
Transfer of IFNgamma-depleted CD4(+) T cells together with CD8(+) T cells leads to rejection of murine kidney sarcoma in mice. ( 10925361 )
2000

Variations for Kidney Sarcoma

Expression for Kidney Sarcoma

Search GEO for disease gene expression data for Kidney Sarcoma.

Pathways for Kidney Sarcoma

Pathways related to Kidney Sarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.62 CREB3L1 MYOD1

GO Terms for Kidney Sarcoma

Biological processes related to Kidney Sarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription from RNA polymerase II promoter GO:0006366 8.8 CREB3L1 MYOD1 WT1

Molecular functions related to Kidney Sarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 8.8 CREB3L1 MYOD1 WT1

Sources for Kidney Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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