MCID: KMR001
MIFTS: 44

Kimura Disease malady

Rare diseases, Bone diseases, Skin diseases, Immune diseases categories

Aliases & Classifications for Kimura Disease

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Kimura Disease, Aliases & Descriptions:

Name: Kimura Disease 9 41 11 43 47 60
Eosinophilic Lymphogranuloma 41 47
Angiolymphoid Hyperplasia with Eosinophilia 41
Eosinophilic Hyperplastic Lymphogranuloma 41
Eosinophilic Lymphofollicular Granuloma 41
 
Eosinophilic Granuloma of Soft Tissue 41
Eosinophilic Lymphofolliculosis 41
Epithelioid Hemangioma of Skin 60
Histiocytoid Hemangioma 60
Kimura's Disease 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Skin diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

47
kimura disease:
Prevalence: <1/1000000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy


External Ids:

Disease Ontology9 DOID:7365
NCIt38 C26867
MeSH33 D000796
Orphanet47 482
MESH via Orphanet34 D000796
ICD10 via Orphanet26 I89.8
UMLS via Orphanet61 C0033838

Summaries for Kimura Disease

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NIH Rare Diseases:41 Kimura disease is a rare, benign, chronic disorder that causes inflammation of tissue (nodules) under the skin of the head or neck.  these nodules tend to recur despite treatment. the cause of this condition is unknown, but may be due to an immune response. last updated: 1/20/2011

MalaCards based summary: Kimura Disease, also known as eosinophilic lymphogranuloma, is related to renal cell carcinoma and skin disease. An important gene associated with Kimura Disease is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and OX40 Pathway. The compounds tolnaftate and loteprednol have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and lymph node, and related mouse phenotypes are respiratory system and immune system.

Related Diseases for Kimura Disease

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Diseases related to Kimura Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1renal cell carcinoma30.4IFNA1
2skin disease30.3IGHE, RNASE3, IL4, IL5
3mycosis fungoides30.3IFNA1, IL5
4eosinophilia29.5IL5, IL4, PRG2, RNASE3, IGHE, IGES
5hemangioma10.8
6histiocytoid hemangioma10.6
7peripheral t-cell lymphoma10.5
8aneurysm10.5
9bronchitis10.4RNASE3
10atherosclerosis10.4
11burns10.4
12follicular mucinosis10.4
13arteriovenous malformation10.4
14varicocele10.4
15angiosarcoma10.4
16scabies10.4
17bowenoid papulosis10.4
18prurigo nodularis10.4
19angiomatosis10.4
20myelofibrosis10.4IFNA1
21nephrotic syndrome10.3
22keratoconjunctivitis10.3RNASE3, IL5
23chronic eosinophilic pneumonia10.3IL5, RNASE3
24giant papillary conjunctivitis10.3RNASE3, IL5
25eosinophilic gastroenteritis10.3IGHE, IL5
26onchocerciasis10.3IL5, RNASE3
27churg-strauss syndrome10.3IL5, RNASE3
28paragonimiasis10.3IL5, IGHE
29pneumonia10.3IL5, IGES
30anisakiasis10.3IGHE, RNASE3
31toxocariasis10.3RNASE3, IGHE
32contact dermatitis10.2IGHE, IL5
33filariasis10.2IGHE, IL5
34strongyloidiasis10.2IGHE, IL5
35dermatographia10.2PRG2, IGHE
36atopic dermatitis10.2IL4, RNASE3
37esophagitis10.2IL5, PRG2
38temporal arteritis10.2
39cervicitis10.2
40juvenile temporal arteritis10.2
41cutaneous leishmaniasis10.2IL4, IL5
42conjunctivitis10.2IGES, IGHE, RNASE3
43immunodeficiency, x-linked, with hyper-igm10.2IGHE, IL4
44leishmaniasis10.1IL4, IL5
45bronchiectasis10.1IGES, IGHE, RNASE3
46pulmonary tuberculosis10.1IL4, IGES
47otitis media10.1RNASE3, IGHE, IGES
48respiratory failure10.1IGES, IGHE, RNASE3
49parasitic helminthiasis infectious disease10.1IL5, RNASE3, IGHE
50eosinophilic pneumonia10.1IGHE, RNASE3, IL5

Graphical network of the top 20 diseases related to Kimura Disease:



Diseases related to kimura disease

Symptoms for Kimura Disease

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Drugs & Therapeutics for Kimura Disease

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Drug clinical trials:

Search ClinicalTrials for Kimura Disease

Search NIH Clinical Center for Kimura Disease

Genetic Tests for Kimura Disease

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Anatomical Context for Kimura Disease

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MalaCards organs/tissues related to Kimura Disease:

31
Skin, Bone, Lymph node, Brain, Colon, Kidney, Salivary gland

Animal Models for Kimura Disease or affiliated genes

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MGI Mouse Phenotypes related to Kimura Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.1PRG2, IL4, IL5, KIT
2MP:00053877.8KIT, IL5, IL4, PRG2, IGHE
3MP:00053977.7KIT, IL5, IL4, PRG2, IGHE

Publications for Kimura Disease

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Articles related to Kimura Disease:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Paradoxical brain embolism associated with Kimura disease mimics watershed infarction. (25447210)
2015
2
Pulmonary embolism as the initial clinical presentation of Kimura disease: case report and literature review. (25699606)
2015
3
Kimura disease manifesting as synchronous bilateral parotid swelling in a young middle-eastern patient. (25544928)
2014
4
Kimura Disease of the Epiglottis: A Case Report and Review of Literature. (23907346)
2013
5
The false-positive finding of left pulmonary Kimura disease on 18F-FDG PET/CT. (23510880)
2013
6
Kimura disease involving a caruncle. (23543681)
2013
7
Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with Kimura disease. (22627370)
2012
8
Kimura disease: CT and MR imaging findings. (22173767)
2012
9
Epitrochlear mass in a patient on maintenance hemodialysis--Kimura disease. (22280213)
2012
10
Juvenile temporal arteritis with perifollicular lymphoid proliferation resembling Kimura disease. Report of a case. (21182505)
2011
11
Kimura disease in the parotid gland. (21239930)
2011
12
Kimura disease with necrosis of the limbs and mononeuritis multiplex. (21418278)
2011
13
Treatment of Kimura disease with intravenous immunoglobulin. (22106083)
2011
14
Head and neck MRI of Kimura disease. (21849365)
2011
15
Kimura disease: An unusual cause of head and neck masses. Report of 2 cases. (20155679)
2010
16
Thrombotic storm in Kimura disease. (19468829)
2010
17
Renal epitelial neoplasia associated with Kimura disease. (20876951)
2010
18
Kimura disease: a case report and review of the Chinese literature. (19052471)
2009
19
Thrombosis of temporal artery and renal vein in Kimura-disease-related nephrotic syndrome. (18066701)
2009
20
Kimura disease of the eyelid in an Indian man. (19594570)
2009
21
Concomitant occurrence of kimura disease and mycosis fungoides in a Lebanese woman: significance and response to rituximab. (19786854)
2009
22
Kimura disease of the epiglottis. (20614304)
2008
23
Kimura disease. (19098588)
2008
24
Kimura disease: review of the literature. (18808562)
2008
25
Simultaneous presentation of Kimura disease and angiolymphoid hyperplasia with eosinophilia. (18645439)
2008
26
Kimura disease in the parotid gland region. (19137639)
2008
27
Kimura disease of extremity: unusual manifestation in a long bone. (18457980)
2008
28
Kimura disease: an unusual cause of cervical lymphadenopathy with salivary gland involvement. (18076832)
2007
29
Kimura disease: diagnostic imaging findings and surgical treatment. (17912083)
2007
30
Kimura disease with proliferative squamous metaplasia: an unusual finding and a potential diagnostic pitfall. (18306548)
2007
31
Kimura disease in an African patient. (16213070)
2006
32
Synchronous unilateral renal cell carcinoma and Kimura disease of the kidney. (16979713)
2006
33
Kimura disease of the eyelid: a clinicopathologic study with electron microscopic observations. (17117118)
2006
34
Angiolymphoid hyperplasia with eosinophilia masquerading as Kimura disease. (15888362)
2005
35
Focal segmental glomerulosclerosis associating Kimura disease. (15957554)
2005
36
Vincristine treatment of nephrotic syndrome complicated by Kimura disease. (15690191)
2005
37
Radiology quiz case 2: Kimura disease. (15492180)
2004
38
Bilateral lacrimal gland involvement with Kimura disease in an African American male. (15197070)
2004
39
Pranlukast regulates tumour growth by attenuating IL-4 production in Kimura disease. (15088141)
2004
40
Kimura disease: a clinicopathologic study of 21 cases. (15087670)
2004
41
Kimura disease in a patient with renal allograft failure secondary to chronic rejection. (12883971)
2003
42
Kimura disease. (14606173)
2003
43
Juvenile temporal arteritis is a manifestation of Kimura disease. (11803281)
2002
44
Steroid-sensitive anemia in a boy on dialysis--an association with Kimura disease. (11149107)
2000
45
A case of Kimura disease treated with interferon and general corticoid therapy]. (10422145)
1999
46
Kimura disease of the orbit and ocular adnexa. (10466591)
1999
47
Pathologic quiz case 1. Kimura disease. (8703396)
1996
48
Kimura disease involving parotid gland and cervical nodes: CT and MR findings. (1545036)
1992
49
CT of Kimura disease. (2505557)
1989
50
Subcutaneous angiolymphoid hyperplasia (Kimura disease). Report of a case. (1191016)
1975

Variations for Kimura Disease

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Expression for genes affiliated with Kimura Disease

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Search GEO for disease gene expression data for Kimura Disease.

Pathways for genes affiliated with Kimura Disease

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Pathways related to Kimura Disease according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.7IL4, IL5
29.7IL4, IL5
39.7IL5, IL4
49.7IL5, IL4
59.7IL5, IL4
69.7IL5, IL4
79.2IL4, IL5, KIT
89.2IFNA1, IL4, IL5
9
Show member pathways
Type III interferon signaling36
9.2IL5, IL4, IFNA1
109.1KIT, IL4, IFNA1
11
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
9.1IL5, IL4, IGHE
129.1IL5, IL4, IGHE
13
Show member pathways
8.7IFNA1, IL4, IL5, KIT
14
Show member pathways
8.7IFNA1, IL4, IL5, KIT
15
Show member pathways
8.4PRG2, IL4, IL5, KIT
16
Show member pathways
8.0IL5, IL4, IFNA1, PRG2, RNASE3

Compounds for genes affiliated with Kimura Disease

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Compounds related to Kimura Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1tolnaftate439.9IL4, IL5
2loteprednol43 1210.8IL5, IL4
3pranlukast43 28 1211.7IL4, IL5, RNASE3
4salmeterol43 49 28 1212.7RNASE3, IL4, IL5
5mometasone43 1210.6IL4, IL5
6unicap439.6IL5, IGHE, RNASE3
7beclomethasone dipropionate439.6RNASE3, IL5, IGHE
8glatiramer acetate43 1210.6IFNA1, IL4, IL5
9toluene diisocyanate439.5RNASE3, IL5, IGHE
10sodium cromoglycate439.5IL5, RNASE3, IGHE
11cetirizine43 28 24 1212.5IL5, RNASE3, IGHE
12il-12439.5IL5, IL4, IFNA1
13ketotifen43 1210.5IGHE, IL5, RNASE3
14omalizumab43 1210.5IL5, IGHE, IL4
15ovomucoid439.5IL4, IGHE, IL5
16methylcellulose439.5IL5, IL4, KIT
17polyinosinic-polycytidylic acid439.5IFNA1, IL4, IL5
18salbutamol43 49 28 24 1213.5IL5, RNASE3, IGHE
192-chlorodeoxyadenosine439.5IFNA1, KIT, IL5
20poly(i-c)439.5IFNA1, IL5, IL4
21itraconazole43 1210.4IL4, IL5, IGHE
22tarc439.3IGHE, IL4, IL5
23ltc4439.3PRG2, IL5, RNASE3
24ivig439.2IGHE, IL4, IL5
25nedocromil sodium439.2IL5, IL4, RNASE3, IGHE
26bleomycin43 1210.2IFNA1, IL4, IL5
27praziquantel43 1210.2IGHE, IL5, IL4, RNASE3
28azelastine43 1210.2IL5, IL4, IGHE, RNASE3
29montelukast43 49 28 1212.2IL5, IL4, RNASE3, IGHE
30budesonide43 49 1211.2IGHE, RNASE3, IL5, IL4
31fluticasone propionate43 49 59 1212.2RNASE3, IGHE, IL4, IL5
32capsaicin43 2810.1IL5, RNASE3, IGHE
33rantes439.1IL5, IFNA1, RNASE3, IL4
34imatinib43 49 1211.1KIT, IL5, IL4, IFNA1
35murabutide439.0IFNA1, IGHE
36prednisolone43 28 1211.0IL5, IGHE, IFNA1, RNASE3
37pgd2438.7IL5, IGHE, RNASE3, PRG2
38indomethacin43 28 59 1211.5IL5, PRG2, IGHE, IL4
39dexamethasone43 49 28 1211.5IL5, IL4, IGHE, RNASE3, IFNA1
40cycloheximide438.4IGHE, IL4, IFNA1, IL5, KIT
41acetylcholine43 49 28 24 1212.2IGHE, IGES, RNASE3, PRG2
42arginine438.2IL5, IL4, IGHE, PRG2, RNASE3
43vegf438.2IL5, IGHE, IFNA1, KIT, RNASE3, IL4
44cyclosporin a43 28 5910.1IGES, IGHE, IFNA1, IL4, IL5, RNASE3
45actinomycin d438.0KIT, IFNA1, PRG2, IGHE, IL4
46methacholine43 49 129.8PRG2, IL5, RNASE3, IGHE, IGES, IL4
47allergens437.8IL4, PRG2, IL5, IGES, IGHE, RNASE3
48tyrosine437.8IL5, IL4, PRG2, RNASE3, KIT, IFNA1
49retinoic acid43 248.7RNASE3, IL5, KIT, PRG2, IFNA1, IGHE
50histamine43 28 249.4IGES, IL4, PRG2, RNASE3, KIT, IGHE

GO Terms for genes affiliated with Kimura Disease

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Cellular components related to Kimura Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.3IL5, PRG2, RNASE3, IGHE

Biological processes related to Kimura Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:00308909.7IL5, IL4
2positive regulation of JAK-STAT cascadeGO:00464279.5KIT, IL5
3positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.3KIT, IL4
4positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.2IL4, IL5, KIT
5immune responseGO:00069558.3IL5, IL4, PRG2, IGHE

Products for genes affiliated with Kimura Disease

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Sources for Kimura Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet