MCID: KMR001
MIFTS: 51

Kimura Disease malady

Rare diseases, Bone diseases, Skin diseases, Immune diseases categories
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Summaries for Kimura Disease

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NIH Rare Diseases:42 Kimura disease is a rare, benign, chronic disorder that causes inflammation of tissue (nodules) under the skin of the head or neck.  these nodules tend to recur despite treatment. the cause of this condition is unknown, but may be due to an immune response. last updated: 1/20/2011

MalaCards based summary: Kimura Disease, also known as angiolymphoid hyperplasia with eosinophilia, is related to skin disease and mycosis fungoides. An important gene associated with Kimura Disease is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and OX40 Pathway. The compounds tolnaftate and loteprednol have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and lymph node, and related mouse phenotypes are respiratory system and immune system.

Aliases & Classifications for Kimura Disease

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Kimura Disease, Aliases & Descriptions:

Name: Kimura Disease 8 42 10 44 48 62
Angiolymphoid Hyperplasia with Eosinophilia 42 62
Eosinophilic Hyperplastic Lymphogranuloma 42 62
Eosinophilic Lymphofollicular Granuloma 42 62
Eosinophilic Granuloma of Soft Tissue 42 62
 
Eosinophilic Lymphofolliculosis 42 62
Disorder Characterized by Eosinophilia 62
Eosinophilic Lymphogranuloma 48
Kimura's Disease 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Skin diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
kimura disease:
Prevalence: <1/1000000; Age of onset: Adulthood; Age of death: Normal


External Ids:

Disease Ontology8 DOID:7365
MeSH34 D000796
NCIt39 C26867
MESH via Orphanet35 D000796
ICD10 via Orphanet26 I89.8
UMLS via Orphanet63 C0033838

Related Diseases for Kimura Disease

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Diseases related to Kimura Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1skin disease30.3IGHE, RNASE3, IL4, IL5
2mycosis fungoides30.3IFNA1, IL5
3eosinophilia29.5IL5, IL4, PRG2, RNASE3, IGHE, IGES
4hemangioma10.8
5histiocytoid hemangioma10.8
6peripheral t-cell lymphoma10.5
7aneurysm10.5
8bronchitis10.5RNASE3
9atherosclerosis10.4
10burns10.4
11follicular mucinosis10.4
12varicocele10.4
13arteriovenous malformation10.4
14angiosarcoma10.4
15scabies10.4
16bowenoid papulosis10.4
17prurigo nodularis10.4
18angiomatosis10.4
19myelofibrosis10.4IFNA1
20keratoconjunctivitis10.3RNASE3, IL5
21nephrotic syndrome10.3
22chronic eosinophilic pneumonia10.3IL5, RNASE3
23giant papillary conjunctivitis10.3RNASE3, IL5
24eosinophilic gastroenteritis10.3IGHE, IL5
25onchocerciasis10.3IL5, RNASE3
26churg-strauss syndrome10.3IL5, RNASE3
27paragonimiasis10.3IL5, IGHE
28pneumonia10.3IL5, IGES
29anisakiasis10.3IGHE, RNASE3
30toxocariasis10.3RNASE3, IGHE
31kidney cancer10.3IFNA1
32contact dermatitis10.3IGHE, IL5
33filariasis10.3IGHE, IL5
34strongyloidiasis10.2IGHE, IL5
35dermatographia10.2PRG2, IGHE
36atopic dermatitis10.2IL4, RNASE3
37esophagitis10.2IL5, PRG2
38cutaneous leishmaniasis10.2IL4, IL5
39conjunctivitis10.2IGES, IGHE, RNASE3
40temporal arteritis10.2
41cervicitis10.2
42juvenile temporal arteritis10.2
43immunodeficiency with hyper igm type 110.2IGHE, IL4
44leishmaniasis10.2IL4, IL5
45bronchiectasis10.1IGES, IGHE, RNASE3
46pulmonary tuberculosis10.1IL4, IGES
47otitis media10.1RNASE3, IGHE, IGES
48respiratory failure10.1IGES, IGHE, RNASE3
49helminthiasis10.1IL5, RNASE3, IGHE
50eosinophilic pneumonia10.1IGHE, RNASE3, IL5

Graphical network of the top 20 diseases related to Kimura Disease:



Diseases related to kimura disease

Symptoms for Kimura Disease

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Drugs & Therapeutics for Kimura Disease

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Drug clinical trials:

Search ClinicalTrials for Kimura Disease

Search NIH Clinical Center for Kimura Disease

Genetic Tests for Kimura Disease

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Anatomical Context for Kimura Disease

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MalaCards organs/tissues related to Kimura Disease:

32
Skin, Bone, Lymph node, Colon, Kidney, Salivary gland

Animal Models for Kimura Disease or affiliated genes

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MGI Mouse Phenotypes related to Kimura Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.1KIT, PRG2, IL4, IL5
2MP:00053877.8IL4, IL5, IGHE, KIT, PRG2
3MP:00053977.7IGHE, PRG2, IL4, IL5, KIT

Publications for Kimura Disease

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Articles related to Kimura Disease:

(show top 50)    (show all 70)
idTitleAuthorsYear
1
Preliminary study of diffusion-weighted imaging and magnetic resonance spectroscopy imaging in kimura disease. (25377973)
2014
2
Kimura Disease of the Epiglottis: A Case Report and Review of Literature. (23907346)
2013
3
The false-positive finding of left pulmonary Kimura disease on 18F-FDG PET/CT. (23510880)
2013
4
Kimura disease involving a caruncle. (23543681)
2013
5
Kimura Disease: rare cause of a slowly progressive orbital mass. (24119195)
2013
6
Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with Kimura disease. (22627370)
2012
7
Kimura disease: CT and MR imaging findings. (22173767)
2012
8
Epitrochlear mass in a patient on maintenance hemodialysis--Kimura disease. (22280213)
2012
9
Juvenile temporal arteritis with perifollicular lymphoid proliferation resembling Kimura disease. Report of a case. (21182505)
2011
10
Kimura disease in the parotid gland. (21239930)
2011
11
Kimura disease with necrosis of the limbs and mononeuritis multiplex. (21418278)
2011
12
Treatment of Kimura disease with intravenous immunoglobulin. (22106083)
2011
13
Head and neck MRI of Kimura disease. (21849365)
2011
14
Kimura disease: An unusual cause of head and neck masses. Report of 2 cases. (20155679)
2010
15
Thrombotic storm in Kimura disease. (19468829)
2010
16
Renal epitelial neoplasia associated with Kimura disease. (20876951)
2010
17
Kimura disease: a case report and review of the Chinese literature. (19052471)
2009
18
Thrombosis of temporal artery and renal vein in Kimura-disease-related nephrotic syndrome. (18066701)
2009
19
Kimura disease of the eyelid in an Indian man. (19594570)
2009
20
Concomitant occurrence of kimura disease and mycosis fungoides in a Lebanese woman: significance and response to rituximab. (19786854)
2009
21
Kimura disease of the epiglottis. (20614304)
2008
22
Kimura disease. (19098588)
2008
23
Kimura disease: review of the literature. (18808562)
2008
24
Simultaneous presentation of Kimura disease and angiolymphoid hyperplasia with eosinophilia. (18645439)
2008
25
Kimura disease in the parotid gland region. (19137639)
2008
26
Kimura disease of extremity: unusual manifestation in a long bone. (18457980)
2008
27
Kimura disease: an unusual cause of cervical lymphadenopathy with salivary gland involvement. (18076832)
2007
28
Kimura disease: diagnostic imaging findings and surgical treatment. (17912083)
2007
29
Kimura disease with proliferative squamous metaplasia: an unusual finding and a potential diagnostic pitfall. (18306548)
2007
30
Kimura disease in an African patient. (16213070)
2006
31
Synchronous unilateral renal cell carcinoma and Kimura disease of the kidney. (16979713)
2006
32
Kimura disease of the eyelid: a clinicopathologic study with electron microscopic observations. (17117118)
2006
33
Angiolymphoid hyperplasia with eosinophilia masquerading as Kimura disease. (15888362)
2005
34
Focal segmental glomerulosclerosis associating Kimura disease. (15957554)
2005
35
Vincristine treatment of nephrotic syndrome complicated by Kimura disease. (15690191)
2005
36
Radiology quiz case 2: Kimura disease. (15492180)
2004
37
Bilateral lacrimal gland involvement with Kimura disease in an African American male. (15197070)
2004
38
Pranlukast regulates tumour growth by attenuating IL-4 production in Kimura disease. (15088141)
2004
39
Kimura disease: a clinicopathologic study of 21 cases. (15087670)
2004
40
Kimura disease in a patient with renal allograft failure secondary to chronic rejection. (12883971)
2003
41
Kimura disease. (14606173)
2003
42
Juvenile temporal arteritis is a manifestation of Kimura disease. (11803281)
2002
43
Steroid-sensitive anemia in a boy on dialysis--an association with Kimura disease. (11149107)
2000
44
Nephrotic syndrome associated with Kimura disease. (10872190)
2000
45
A case of Kimura disease treated with interferon and general corticoid therapy]. (10422145)
1999
46
Kimura disease of the orbit and ocular adnexa. (10466591)
1999
47
Pathologic quiz case 1. Kimura disease. (8703396)
1996
48
Kimura disease involving parotid gland and cervical nodes: CT and MR findings. (1545036)
1992
49
CT of Kimura disease. (2505557)
1989
50
Subcutaneous angiolymphoid hyperplasia (Kimura disease). Report of a case. (1191016)
1975

Variations for Kimura Disease

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Expression for genes affiliated with Kimura Disease

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Expression patterns in normal tissues for genes affiliated with Kimura Disease

Search GEO for disease gene expression data for Kimura Disease.

Pathways for genes affiliated with Kimura Disease

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Pathways related to Kimura Disease according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.7IL4, IL5
29.7IL4, IL5
39.7IL5, IL4
49.7IL5, IL4
59.7IL5, IL4
69.7IL5, IL4
79.7IL5, IL4
89.2IL4, IL5, KIT
99.2IFNA1, IL4, IL5
10
Show member pathways
Type III interferon signaling37
9.2IL5, IL4, IFNA1
119.1KIT, IL4, IFNA1
12
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
9.1IL5, IL4, IGHE
139.1IL5, IL4, IGHE
14
Show member pathways
8.7IFNA1, IL4, IL5, KIT
15
Show member pathways
8.7IFNA1, IL4, IL5, KIT
16
Show member pathways
8.4PRG2, IL4, IL5, KIT
17
Show member pathways
8.0IL5, IL4, IFNA1, PRG2, RNASE3

Compounds for genes affiliated with Kimura Disease

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Compounds related to Kimura Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1tolnaftate449.9IL4, IL5
2loteprednol44 1110.8IL5, IL4
3pranlukast44 28 1111.7IL4, IL5, RNASE3
4salmeterol44 50 28 1112.7RNASE3, IL4, IL5
5mometasone44 1110.6IL4, IL5
6unicap449.6IL5, IGHE, RNASE3
7beclomethasone dipropionate449.6RNASE3, IL5, IGHE
8glatiramer acetate44 1110.6IFNA1, IL4, IL5
9toluene diisocyanate449.5RNASE3, IL5, IGHE
10sodium cromoglycate449.5IL5, RNASE3, IGHE
11cetirizine44 28 24 1112.5IL5, RNASE3, IGHE
12il-12449.5IL5, IL4, IFNA1
13ketotifen44 1110.5IGHE, IL5, RNASE3
14omalizumab44 1110.5IL5, IGHE, IL4
15ovomucoid449.5IL4, IGHE, IL5
16methylcellulose449.5IL5, IL4, KIT
17polyinosinic-polycytidylic acid449.5IFNA1, IL4, IL5
18salbutamol44 50 28 24 1113.5IL5, RNASE3, IGHE
192-chlorodeoxyadenosine449.5IFNA1, KIT, IL5
20poly(i-c)449.5IFNA1, IL5, IL4
21itraconazole44 1110.4IL4, IL5, IGHE
22tarc449.3IGHE, IL4, IL5
23ltc4449.3PRG2, IL5, RNASE3
24ivig449.2IGHE, IL4, IL5
25nedocromil sodium449.2IL5, IL4, RNASE3, IGHE
26bleomycin44 1110.2IFNA1, IL4, IL5
27praziquantel44 1110.2IGHE, IL5, IL4, RNASE3
28azelastine44 1110.2IL5, IL4, IGHE, RNASE3
29montelukast44 50 28 1112.2IL5, IL4, RNASE3, IGHE
30budesonide44 50 1111.2IGHE, RNASE3, IL5, IL4
31fluticasone propionate44 50 61 1112.2RNASE3, IGHE, IL4, IL5
32capsaicin44 2810.1IL5, RNASE3, IGHE
33rantes449.1IL5, IFNA1, RNASE3, IL4
34imatinib44 50 1111.1KIT, IL5, IL4, IFNA1
35murabutide449.0IFNA1, IGHE
36prednisolone44 28 1111.0IL5, IGHE, IFNA1, RNASE3
37pgd2448.7IL5, IGHE, RNASE3, PRG2
38indomethacin44 28 61 1111.5IL5, PRG2, IGHE, IL4
39dexamethasone44 50 28 1111.5IL5, IL4, IGHE, RNASE3, IFNA1
40cycloheximide448.4IGHE, IL4, IFNA1, IL5, KIT
41acetylcholine44 50 28 24 1112.2IGHE, IGES, RNASE3, PRG2
42arginine448.2IL5, IL4, IGHE, PRG2, RNASE3
43vegf448.2IL5, IGHE, IFNA1, KIT, RNASE3, IL4
44cyclosporin a44 28 6110.1IGES, IGHE, IFNA1, IL4, IL5, RNASE3
45actinomycin d448.0KIT, IFNA1, PRG2, IGHE, IL4
46methacholine44 50 119.8PRG2, IL5, RNASE3, IGHE, IGES, IL4
47allergens447.8IL4, PRG2, IL5, IGES, IGHE, RNASE3
48tyrosine447.8IL5, IL4, PRG2, RNASE3, KIT, IFNA1
49retinoic acid44 248.7RNASE3, IL5, KIT, PRG2, IFNA1, IGHE
50histamine44 28 249.4IGES, IL4, PRG2, RNASE3, KIT, IGHE

GO Terms for genes affiliated with Kimura Disease

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Cellular components related to Kimura Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.3IL5, PRG2, RNASE3, IGHE

Biological processes related to Kimura Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:0308909.7IL5, IL4
2positive regulation of JAK-STAT cascadeGO:0464279.5KIT, IL5
3positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.3KIT, IL4
4positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.2IL4, IL5, KIT
5immune responseGO:0069558.3IL5, IL4, PRG2, IGHE

Products for genes affiliated with Kimura Disease

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Sources for Kimura Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet