MCID: KMR001
MIFTS: 50

Kimura Disease malady

Categories: Rare diseases, Bone diseases, Skin diseases, Immune diseases

Aliases & Classifications for Kimura Disease

Aliases & Descriptions for Kimura Disease:

Name: Kimura Disease 12 50 56 52 14 69
Angiolymphoid Hyperplasia with Eosinophilia 50
Eosinophilic Hyperplastic Lymphogranuloma 50
Eosinophilic Lymphofollicular Granuloma 50
Eosinophilic Granuloma of Soft Tissue 50
Eosinophilic Lymphofolliculosis 50
Eosinophilic Lymphogranuloma 56
Kimura's Disease 12

Characteristics:

Orphanet epidemiological data:

56
kimura disease
Prevalence: <1/1000000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:7365
MeSH 42 D000796
NCIt 47 C26867
Orphanet 56 ORPHA482
UMLS via Orphanet 70 C0033838
MESH via Orphanet 43 D000796
ICD10 via Orphanet 34 I89.8
UMLS 69 C0033838

Summaries for Kimura Disease

NIH Rare Diseases : 50 kimura disease is a rare, benign, chronic disorder that causes inflammation of tissue (nodules) under the skin of the head or neck.  these nodules tend to recur despite treatment. the cause of this condition is unknown, but may be due to an immune response. last updated: 1/20/2011

MalaCards based summary : Kimura Disease, also known as angiolymphoid hyperplasia with eosinophilia, is related to histiocytoid hemangioma and skin epithelioid hemangioma, and has symptoms including eosinophilia, increased ige level and abnormality of the salivary glands. An important gene associated with Kimura Disease is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Carvedilol and Pitavastatin have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for Kimura Disease

Diseases related to Kimura Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
id Related Disease Score Top Affiliating Genes
1 histiocytoid hemangioma 11.5
2 skin epithelioid hemangioma 11.2
3 hemangioma 10.3
4 restrictive cardiomyopathy 10.3 IL5 RNASE3
5 renal hypertension 10.2 IL5 RNASE3
6 brown shrimp allergy 10.2 IL5 RNASE3
7 papillary squamous carcinoma 10.2 IL4 IL5
8 hypersensitivity vasculitis 10.2 IL4 IL5
9 benign meningioma 10.2 IL5 RNASE3
10 peptidic growth factors deficiency 10.2 CCL11 IL5
11 allescheriosis 10.2 IL4 IL5
12 urethral intrinsic sphincter deficiency 10.2 IL4 IL5
13 bone peripheral neuroepithelioma 10.2 IL4 IL5
14 indian plum allergy 10.2 IL4 IL5
15 natural killer cell leukemia 10.2 CCL11 IL5
16 lactose intolerance 10.2 IL4 IL5
17 askin's tumor 10.2 IL4 IL5
18 spastic diplegia 10.2 CCL11 IL5
19 breast intracanalicular fibroadenoma 10.2 IL4 IL5
20 histoplasmosis retinitis 10.2 IL4 IL5
21 metal allergy 10.2 IL5 RNASE3
22 hypercementosis 10.2 CCL5 IL5
23 psychotic disorder 10.2 CCL11 IL4
24 bile duct signet ring cell carcinoma 10.2 IL5 RNASE3
25 isolated klippel-feil syndrome 10.2 IL4 IL5
26 retinal vascular disease 10.2 CCL11 IL4
27 small intestine lymphoma 10.2 IL5 RNASE3
28 dissociated nystagmus 10.2 IL4 IL5
29 vulvar disease 10.2 CCL5 RNASE3
30 isthmus cancer 10.2 CCL11 IL4
31 duodenal somatostatinoma 10.2 IL4 IL5
32 coenurosis 10.2 IL4 IL5
33 smooth muscle tumor 10.2 CCL5 IL5
34 astrocytoma 10.2 IL5 RNASE3
35 hidradenitis suppurativa 10.1 CCL11 CCL5
36 central nervous system origin vertigo 10.1 IL4 RNASE3
37 leukoplakia of penis 10.1 CCL5 IL4
38 marasmus 10.1 IL4 IL5 RNASE3
39 lens-induced iridocyclitis 10.1 IL4 IL5 RNASE3
40 abnormal retinal correspondence 10.1 IL4 IL5
41 spastic paraplegia 3a, autosomal dominant 10.1 IL4 IL5 RNASE3
42 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.1 IL4 IL5 RNASE3
43 luminal breast carcinoma 10.1 IL4 IL5 RNASE3
44 wilkes stevenson syndrome 10.1 IL5 RNASE3
45 acute gonococcal prostatitis 10.1 IL4 IL5 RNASE3
46 orbit alveolar rhabdomyosarcoma 10.1 IL4 IL5 RNASE3
47 actinic keratosis 10.1 IL4 IL5 RNASE3
48 paratyphoid fever 10.1 IL4 IL5 RNASE3
49 uterus interstitial leiomyoma 10.1 IL4 IL5 RNASE3
50 necrotizing gastritis 10.1 CCL11 IL5 RNASE3

Graphical network of the top 20 diseases related to Kimura Disease:



Diseases related to Kimura Disease

Symptoms & Phenotypes for Kimura Disease

Human phenotypes related to Kimura Disease:

56 32
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 eosinophilia 56 32 Very frequent (99-80%) HP:0001880
2 increased ige level 56 32 Very frequent (99-80%) HP:0003212
3 abnormality of the salivary glands 56 32 Occasional (29-5%) HP:0010286
4 follicular hyperplasia 56 32 Very frequent (99-80%) HP:0002729
5 lymphadenopathy 56 Frequent (79-30%)

MGI Mouse Phenotypes related to Kimura Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CCL11 CCL5 CCR3 IL33 IL4 IL5
2 immune system MP:0005387 9.5 CCL5 CCR3 IL33 IL4 IL5 TSLP
3 respiratory system MP:0005388 9.1 CCL11 CCR3 IL33 IL4 IL5 TSLP

Drugs & Therapeutics for Kimura Disease

Drugs for Kimura Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 155)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
2
Pitavastatin Approved Phase 4 147511-69-1, 147526-32-7 6366718 5282452
3
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
4
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
5
Ticlopidine Approved Phase 4 55142-85-3 5472
6
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
7
Everolimus Approved Phase 4 159351-69-6 6442177
8
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3 148553-50-8 5486971
9
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
10
Warfarin Approved Phase 4 81-81-2 6691 54678486
11
Rivaroxaban Approved Phase 4 366789-02-8
12
Apixaban Approved Phase 4 503612-47-3 10182969
13 Edoxaban Approved Phase 4 480449-70-5
14
Losartan Approved Phase 4 114798-26-4 3961
15
Clopidogrel Approved, Nutraceutical Phase 4 120202-66-6, 113665-84-2 60606
16
protease inhibitors Phase 4
17 Adrenergic Agents Phase 4,Phase 1
18 Adrenergic Antagonists Phase 4,Phase 1
19 Adrenergic alpha-1 Receptor Antagonists Phase 4
20 Adrenergic alpha-Antagonists Phase 4
21 Neurotransmitter Agents Phase 4,Phase 1
22 Adrenergic beta-Antagonists Phase 4,Phase 1
23 HIV Protease Inhibitors Phase 4
24 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1
25 Vasodilator Agents Phase 4,Phase 3,Phase 1
26 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
27 Hypolipidemic Agents Phase 4
28 Anti-Infective Agents Phase 4,Phase 1,Phase 2
29 Immunosuppressive Agents Phase 4,Phase 3,Phase 1,Phase 2
30 Anticholesteremic Agents Phase 4
31 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1
32 Antihypertensive Agents Phase 4
33 Lipid Regulating Agents Phase 4
34 Antimetabolites Phase 4,Phase 1,Phase 2
35
Angiotensin II Phase 4 68521-88-0, 11128-99-7 65143 172198
36 Atorvastatin Calcium Phase 4 134523-03-8
37 Analgesics Phase 4,Phase 3,Phase 1
38 calcium channel blockers Phase 4,Phase 3
39 diuretics Phase 4
40 Cyclooxygenase Inhibitors Phase 4
41 Cytochrome P-450 Enzyme Inhibitors Phase 4
42 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 1
43 Tranquilizing Agents Phase 4,Phase 3
44 Angiotensin II Type 1 Receptor Blockers Phase 4
45 Angiotensin Receptor Antagonists Phase 4
46 Angiotensin-Converting Enzyme Inhibitors Phase 4
47 Angiotensinogen Phase 4
48 Anti-Anxiety Agents Phase 4,Phase 3
49 Anti-Bacterial Agents Phase 4
50 Platelet Aggregation Inhibitors Phase 4

Interventional clinical trials:

(show top 50) (show all 56)
id Name Status NCT ID Phase
1 The Preventive Efficacy of Carvedilol on Cardiac Dysfunction in Duchenne Muscular Dystrophy Unknown status NCT00606775 Phase 4
2 Kanagawa Valsartan Trial (KVT): Effects of Valsartan on Renal and Cardiovascular Disease Completed NCT00190580 Phase 4
3 Clopidogrel High Dose Evaluation for the Patient With Coronary Artery Disease in Japan Completed NCT01069302 Phase 4
4 Evaluation of Routine Follow-up Coronary Angiography After Percutaneous Coronary Intervention Trial Completed NCT01123291 Phase 4
5 Randomized Evaluation of Sirolimus-eluting Versus Everolimus-eluting Stent Trial Completed NCT01035450 Phase 4
6 Short and Optimal Duration of Dual Antiplatelet Therapy Study Completed NCT01659034 Phase 4
7 NOBORI Biolimus-Eluting Versus XIENCE/PROMUS Everolimus-eluting Stent Trial Completed NCT01303640 Phase 4
8 Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome (JAPAN-ACS) Completed NCT00242944 Phase 4
9 Effect of Passive Exercise on Systemic Endothelial Function in Elderly Patients With Chronic Heart Failure Completed NCT00733161 Phase 4
10 The Study on Profile and Genetic Factors of Aspirin Resistance (ProGEAR Study) Completed NCT00250380 Phase 4
11 Carvedilol Post-intervention Long-term Administration in Large-scale Trial Completed NCT01155635 Phase 4
12 PROs in Chronic Low Back Pain Patients With Accompanying Lower Limb Pain (Neuropathic Component) Treated With Pregabalin Completed NCT02273908 Phase 4
13 ShorT and OPtimal Duration of Dual AntiPlatelet Therapy-2 Study Recruiting NCT02619760 Phase 4
14 Optimizing Antithrombotic Care in Patients With AtriaL fibrillatiON and Coronary stEnt (OAC-ALONE) Study Recruiting NCT01962545 Phase 4
15 Anti-inflammatory Effects of Rivaroxaban Versus Dabigatran Recruiting NCT02331602 Phase 4
16 The Preventive Implantation of Bioresorbable Vascular Scaffold on Functionally Insignificant Stenosis With Vulnerable Plaque Characteristics Recruiting NCT02316886 Phase 4
17 Effect of Intensive Blood Pressure Control on Progression of Coronary Atherosclerosis: Randomized Evaluation by Intravascular Ultrasound Terminated NCT01230216 Phase 4
18 Treatment of Schizophrenia With an Omega-3 Fatty Acid (EPA) and Antioxidants Completed NCT00419146 Phase 2, Phase 3
19 A Study of Icatibant in Patients With Acute Attacks of Hereditary Angioedema (FAST-3) Completed NCT00912093 Phase 3
20 An Open-Label Long-Term Study Of Pregabalin For The Treatment Of Central Neuropathic Pain Completed NCT01202227 Phase 3
21 Aromatase Inhibitors or GnRH-a for Uterine Adenomyosis Completed NCT01218581 Phase 2, Phase 3
22 A Phase 3 Study To Compare The Efficacy And Safety Of 0.3 MG Pegaptanib Sodium To Sham Injections In Subjects With Diabetic Macular Edema Completed NCT01100307 Phase 3
23 PhaseⅢOpen-label Study of MRA for Rheumatoid Arthritis(RA) Completed NCT00380601 Phase 3
24 Long-term Treatment Study of MRA for Rheumatoid Arthritis (RA) From Study MRA220JP or MRA221JP Completed NCT00144586 Phase 3
25 A Phase3 Study to Evaluate the Efficacy and Safety of MEDI3250 in Healthy Japanese Children Age 7 Years Through 18 Years Completed NCT02269475 Phase 3
26 Safety and Efficacy of Abicipar Pegol in Patients With Neovascular Age-related Macular Degeneration Active, not recruiting NCT02462486 Phase 3
27 Study of Cetuximab With Concomitant-boost Radiotherapy in Patients With Newly Diagnosed Locally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN) Completed NCT00865098 Phase 2
28 Low Intensity Physical Activity Leads to Improvement in Brachial-ankle Pulse Wave Velocity of Hemiplegics Completed NCT01569386 Phase 2
29 Antiangiogenic Peptide Vaccine Therapy With Gemcitabine in Treating Patient With Pancreatic Cancer (Phase1/2) Completed NCT00655785 Phase 1, Phase 2
30 Neoadjuvant Nab-PTX and Trastuzumab for ER Negative and HER2 Positive Breast Cancer Recruiting NCT02598310 Phase 2
31 Ponatinib in Patients With Resistant Chronic Phase Chronic Myeloid Leukemia (CML) to Characterize the Efficacy and Safety of a Range of Doses Recruiting NCT02467270 Phase 2
32 Study of TBI-1501 for Relapsed or Refractory Acute Lymphoblastic Leukemia Not yet recruiting NCT03155191 Phase 1, Phase 2
33 Antiangiogenic Peptide Vaccine Therapy With Gemcitabine in Treating Patient With Pancreatic Cancer Unknown status NCT00639925 Phase 1
34 Antiangiogenic Peptide Vaccine Therapy in Treating Patient With Hepatocellular Carcinoma Unknown status NCT01266707 Phase 1
35 Open-label, Single-arm Study to Assess the Pharmacokinetics, Safety, and Tolerability of a Single Subcutaneous Dose of Icatibant in Healthy Japanese Volunteers Completed NCT02045264 Phase 1
36 An Open Label, Single Arm, Dose Escalation Phase 1 Trial of PRI-724 in Patients With HCV-induced Cirrhosis Recruiting NCT02195440 Phase 1
37 Randomized Evaluation of Aggressive or Moderate Lipid Lowering Therapy With Pitavastatin in Coronary Artery Disease (REAL-CAD) Unknown status NCT01042730
38 Comparison of Novo Rapid 30 Mix Injection FlexPen® and Humalog 25 Mix Injection KwikPen® in Type 2 Diabetic Patients Unknown status NCT00806975
39 Study of Aprepitant / Fosaprepitant for the Prevention of Chemotherapy-induced Nausea and Vomiting (CINV) in Colorectal Cancer Patients - SENRI Trial Unknown status NCT01344304
40 The Cardiac Insufficiency BIsoprolol Study in Japanese Patients With Chronic Heart Failure (CIBIS-J) Unknown status NCT02137733
41 Epithelioid Hemangioma of Bone And Soft Tissue Completed NCT03169595
42 A Study of Duration of Maintained Efficacy in Rheumatoid Arthritis (RA) Patients Off Treatment With MRA(a Development Code of Tocilizumab, an Anti IL-6 Receptor Monoclonal Antibody.) Completed NCT00661284
43 Retina Projection System Trials for Low Vision People Completed NCT00219427
44 The Effect of Adaptive Servo Ventilation and Oxygen Therapy in Central Sleep Apnea Patients Completed NCT01187823
45 Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry Recruiting NCT02418442
46 Start Time Optimization of Biologics in Polyarticular JIA Recruiting NCT02593006
47 Kyoto Congestive Heart Failure Study Recruiting NCT02334891
48 A Follow-up Evaluation Study of PRI-724-1101 Recruiting NCT02828254
49 Gastric Cancer Screening Quality Improvement System Establishment Recruiting NCT02457624
50 Japanese Idiopathic Interstitial Pneumonias Registry Recruiting NCT03041623

Search NIH Clinical Center for Kimura Disease

Genetic Tests for Kimura Disease

Anatomical Context for Kimura Disease

MalaCards organs/tissues related to Kimura Disease:

39
Skin, Lymph Node, Bone, Salivary Gland, Colon, Breast, Brain

Publications for Kimura Disease

Articles related to Kimura Disease:

(show top 50) (show all 94)
id Title Authors Year
1
Kimura disease. No age or ethnicity limit. ( 26905356 )
2016
2
Concurrent Kimura disease and lupus nephritis: A case report. ( 27741124 )
2016
3
Kimura Disease Presenting as Forehead Soft Mass. ( 27100647 )
2016
4
Comparison of Local Recurrence Rate of Three Treatment Modalities for Kimura Disease. ( 26674917 )
2016
5
Human Polyomavirus-6 Infecting Lymph Nodes of a Patient With an Angiolymphoid Hyperplasia With Eosinophilia or Kimura Disease. ( 26962076 )
2016
6
An Unusual Clinical Presentation of Kimura Disease Manifesting with a Typical Cephalocervical Lesion and an Atypical Subcutaneous Hip Mass Lesion. ( 27086824 )
2016
7
Kimura disease in a Maori man with nephrotic syndrome. ( 27981775 )
2016
8
Kimura Disease of the Breast - A Previously Undescribed Entity. ( 27058987 )
2016
9
Kimura disease as mimicker of lymphoma - A case report. ( 27728556 )
2016
10
A case of refractory Kimura disease with a buccal bulky mass successfullyA treated with low-dose cyclosporine A: Report andA reviewA ofA the literature. ( 26666475 )
2016
11
Eosinophilia and multiple lymphadenopathy: Kimura disease, a rare, but benign condition. ( 27581232 )
2016
12
A mass under parotid gland: a patient with kimura disease. ( 25668110 )
2015
13
Retrospective Multicentric Study of 25 Kimura Disease Patients: Emphasis on Therapeutics and Shared Features with Cutaneous IgG4-Related Disease. ( 26452023 )
2015
14
Recurrent Kimura Disease of the Inner Canthus With No Lymphadenopathy. ( 26020715 )
2015
15
Kimura disease associated with severe visual dysfunction due to remarkable periorbital involvement. ( 26031497 )
2015
16
Pulmonary embolism as the initial clinical presentation of Kimura disease: case report and literature review. ( 25699606 )
2015
17
Kimura disease accompanied with nephrotic syndrome in a 45-year-old male. ( 25928198 )
2015
18
Kimura disease: A rare case of bilateral infra-auricular masses. ( 26831431 )
2015
19
Paradoxical brain embolism associated with Kimura disease mimics watershed infarction. ( 25447210 )
2015
20
Kimura Disease Presenting As an Eyelid Mass in a Young Asian Male. ( 26080258 )
2015
21
Kimura Disease Mimicking an Aneurysm of the Radial Artery. ( 26362092 )
2015
22
Unusual Cause of Swelling in the Upper Limb: Kimura Disease. ( 26421119 )
2015
23
Preliminary study of diffusion-weighted imaging and magnetic resonance spectroscopy imaging in kimura disease. ( 25377973 )
2014
24
Kimura disease complicated with bowel infarction and multiple arterial thromboses in the extremities. ( 24356478 )
2014
25
Kimura disease manifesting as synchronous bilateral parotid swelling in a young middle-eastern patient. ( 25544928 )
2014
26
Kimura Disease Simulating Hodgkin's Lymphoma on (18)F FDG PET-CT: Report of a Case. ( 26396638 )
2014
27
Kimura disease associated with IgA nephropathy. ( 24656163 )
2014
28
Kimura Disease: rare cause of a slowly progressive orbital mass. ( 24119195 )
2013
29
Intraparotid Kimura disease. ( 23021002 )
2013
30
Kimura Disease of the Epiglottis: A Case Report and Review of Literature. ( 23907346 )
2013
31
The false-positive finding of left pulmonary Kimura disease on 18F-FDG PET/CT. ( 23510880 )
2013
32
Kimura disease involving a caruncle. ( 23543681 )
2013
33
Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with Kimura disease. ( 22627370 )
2012
34
Kimura disease: CT and MR imaging findings. ( 22173767 )
2012
35
Kimura disease: diagnostic challenges and clinical management. ( 21763034 )
2012
36
Treatment of Kimura disease with photodynamic therapy: a case study. ( 22369733 )
2012
37
Epitrochlear mass in a patient on maintenance hemodialysis--Kimura disease. ( 22280213 )
2012
38
Kimura disease: a case report and review of the literature with a new management protocol. ( 21423602 )
2011
39
Treatment of Kimura disease with intravenous immunoglobulin. ( 22106083 )
2011
40
Microfilaria in lymph node mimicking Kimura disease. ( 23508372 )
2011
41
Head and neck MRI of Kimura disease. ( 21849365 )
2011
42
Kimura disease in children: a case report and a summary of the literature in Chinese. ( 21436734 )
2011
43
Kimura disease in the parotid gland. ( 21239930 )
2011
44
Kimura disease with necrosis of the limbs and mononeuritis multiplex. ( 21418278 )
2011
45
Juvenile temporal arteritis with perifollicular lymphoid proliferation resembling Kimura disease. Report of a case. ( 21182505 )
2011
46
Thrombotic storm in Kimura disease. ( 19468829 )
2010
47
Renal epitelial neoplasia associated with Kimura disease. ( 20876951 )
2010
48
Kimura disease: An unusual cause of head and neck masses. Report of 2 cases. ( 20155679 )
2010
49
Kimura disease: a case report and review of the Chinese literature. ( 19052471 )
2009
50
Kimura disease of the eyelid in an Indian man. ( 19594570 )
2009

Variations for Kimura Disease

Expression for Kimura Disease

Search GEO for disease gene expression data for Kimura Disease.

Pathways for Kimura Disease

Pathways related to Kimura Disease according to GeneCards Suite gene sharing:

(show all 21)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.27 CCL11 CCL5 CCR3 IL4 IL5 TSLP
2
Show member pathways
13.1 CCL11 CCL5 CCR3 IL4 IL5
3
Show member pathways
13.04 CCL11 CCL5 IL33 IL4 IL5
4
Show member pathways
12.97 CCL11 CCL5 CCR3 IL4 IL5
5
Show member pathways
12.54 CCL11 IL4 IL5 RNASE3
6
Show member pathways
12.09 CCL11 CCL5 CCR3
7
Show member pathways
12.08 CCL11 IL4 IL5
8
Show member pathways
11.94 IL4 IL5 TSLP
9
Show member pathways
11.7 CCL11 CCL5 CCR3
10 11.65 CCR3 IL4 IL5
11 11.46 IL33 IL4 IL5 TSLP
12 11.34 CCL11 IL4 IL5
13 11.29 CCL5 IL4
14 11.13 CCL11 IL33 IL4 IL5
15 11.11 IL4 IL5
16 11.06 IL4 IL5
17 10.96 IL4 IL5
18 10.85 CCL11 CCL5 IL4 IL5
19 10.82 CCL11 CCL5 CCR3 IL4 IL5
20 10.76 IL33 IL4 IL5 TSLP
21 10.65 IL4 IL5

GO Terms for Kimura Disease

Cellular components related to Kimura Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL11 CCL5 IL33 IL4 IL5 RNASE3
2 extracellular space GO:0005615 9.17 CCL11 CCL5 IL33 IL4 IL5 RNASE3

Biological processes related to Kimura Disease according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.73 CCL11 CCL5 IL4 IL5
2 inflammatory response GO:0006954 9.67 CCL11 CCL5 CCR3 IL5
3 positive regulation of T cell proliferation GO:0042102 9.57 CCL5 IL4
4 response to cytokine GO:0034097 9.56 CCL5 IL4
5 cellular response to interferon-gamma GO:0071346 9.55 CCL11 CCL5
6 cellular defense response GO:0006968 9.54 CCR3 IL4
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.52 CCL5 IL4
8 monocyte chemotaxis GO:0002548 9.51 CCL11 CCL5
9 positive regulation of B cell proliferation GO:0030890 9.49 IL4 IL5
10 innate immune response in mucosa GO:0002227 9.48 IL4 RNASE3
11 positive regulation of JAK-STAT cascade GO:0046427 9.46 CCL5 IL5
12 positive regulation of immunoglobulin secretion GO:0051024 9.4 IL33 IL5
13 eosinophil chemotaxis GO:0048245 9.32 CCL11 CCL5
14 positive regulation of interleukin-13 production GO:0032736 9.26 IL33 IL4
15 type 2 immune response GO:0042092 9.16 IL33 IL4
16 chemokine-mediated signaling pathway GO:0070098 9.13 CCL11 CCL5 CCR3
17 chemotaxis GO:0006935 8.92 CCL11 CCL5 CCR3 IL4

Molecular functions related to Kimura Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL11 CCL5 IL33 IL4 IL5 TSLP
2 chemokine activity GO:0008009 8.96 CCL11 CCL5

Sources for Kimura Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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