MCID: KMR001
MIFTS: 48

Kimura Disease

Categories: Rare diseases, Immune diseases, Bone diseases, Skin diseases

Aliases & Classifications for Kimura Disease

MalaCards integrated aliases for Kimura Disease:

Name: Kimura Disease 12 72 49 55 51 14 69
Angiolymphoid Hyperplasia with Eosinophilia 49
Eosinophilic Hyperplastic Lymphogranuloma 49
Eosinophilic Lymphofollicular Granuloma 49
Eosinophilic Granuloma of Soft Tissue 49
Eosinophilic Lymphofolliculosis 49
Eosinophilic Lymphogranuloma 55
Kimura's Disease 12

Characteristics:

Orphanet epidemiological data:

55
kimura disease
Prevalence: <1/1000000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:7365
MeSH 41 D000796
NCIt 46 C26867
Orphanet 55 ORPHA482
MESH via Orphanet 42 D000796
UMLS via Orphanet 70 C0033838
ICD10 via Orphanet 33 I89.8
SNOMED-CT via HPO 65 10890000
UMLS 69 C0033838

Summaries for Kimura Disease

NIH Rare Diseases : 49 Kimura disease is a rare, benign, chronic disorder that causes inflammation of tissue (nodules) under the skin of the head or neck.  These nodules tend to recur despite treatment. The cause of this condition is unknown, but may be due to an immune response. Last updated: 1/20/2011

MalaCards based summary : Kimura Disease, also known as angiolymphoid hyperplasia with eosinophilia, is related to loeffler endocarditis and paragonimiasis, and has symptoms including eosinophilia, follicular hyperplasia and increased ige level. An important gene associated with Kimura Disease is IL5 (Interleukin 5), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. Affiliated tissues include lymph node, skin and salivary gland, and related phenotypes are hematopoietic system and immune system

Wikipedia : 72 Kimura\'s disease is a benign rare chronic inflammatory disorder. Its primary symptoms are subdermal... more...

Related Diseases for Kimura Disease

Diseases related to Kimura Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 loeffler endocarditis 10.4 IL5 RNASE3
2 paragonimiasis 10.4 IL5 RNASE3
3 cow milk allergy 10.4 IL5 RNASE3
4 egg allergy 10.4 IL4 IL5
5 trichinosis 10.3 IL4 IL5
6 non-suppurative otitis media 10.3 IL4 IL5
7 scleritis 10.3 IL4 IL5
8 apple allergy 10.3 IL4 IL5
9 sinusitis 10.3 IL5 RNASE3
10 pemphigoid gestationis 10.3 CCL11 IL5
11 cellulitis 10.3 IL5 RNASE3
12 chronic meningitis 10.3 CCL11 IL5
13 cercarial dermatitis 10.3 IL4 IL5
14 pollen allergy 10.3 IL5 RNASE3
15 intestinal schistosomiasis 10.3 IL4 IL5
16 chronic tic disorder 10.3 IL4 IL5
17 toxic oil syndrome 10.3 IL4 IL5
18 strongyloidiasis 10.3 CCL11 IL5
19 primary amebic meningoencephalitis 10.3 IL4 IL5
20 wells syndrome 10.3 IL5 RNASE3
21 churg-strauss syndrome 10.3 IL5 RNASE3
22 enterobiasis 10.3 IL4 IL5
23 respiratory syncytial virus infectious disease 10.3 CCL5 IL5
24 allergic bronchopulmonary aspergillosis 10.3 IL4 IL5
25 papillary conjunctivitis 10.3 CCL11 IL4
26 giant papillary conjunctivitis 10.3 CCL11 IL4
27 maxillary sinusitis 10.2 CCL5 RNASE3
28 paranasal sinus disease 10.2 IL4 IL5
29 blepharitis 10.2 CCL11 IL4
30 paracoccidioidomycosis 10.2 IL4 IL5
31 ocular cicatricial pemphigoid 10.2 IL4 RNASE3
32 vulvovaginitis 10.2 CCL11 CCL5
33 vernal conjunctivitis 10.2 IL4 RNASE3
34 yellow fever 10.2 CCL5 IL5
35 nephrotic syndrome 10.2
36 genital herpes 10.2 CCL5 IL4
37 dermatitis herpetiformis 10.1 CCL11 IL4
38 cough variant asthma 10.1 IL4 IL5 RNASE3
39 atopic keratoconjunctivitis 10.1 IL4 IL5 RNASE3
40 intrinsic asthma 10.1 IL4 IL5 RNASE3
41 inflammatory bowel disease 4 10.1 IL4 IL5 RNASE3
42 latex allergy 10.1 IL4 IL5 RNASE3
43 urinary schistosomiasis 10.1 IL4 IL5 RNASE3
44 milk allergy 10.1 IL4 IL5 RNASE3
45 parasitic helminthiasis infectious disease 10.1 IL4 IL5 RNASE3
46 food allergy 10.1 IL4 IL5 RNASE3
47 schistosomiasis 10.1 IL4 IL5 RNASE3
48 corneal ulcer 10.1 CCL11 CCR3
49 eosinophilic gastroenteritis 10.1 CCL11 IL5 RNASE3
50 cutaneous leishmaniasis 10.1 IL4 IL5

Graphical network of the top 20 diseases related to Kimura Disease:



Diseases related to Kimura Disease

Symptoms & Phenotypes for Kimura Disease

Human phenotypes related to Kimura Disease:

55 31 (show all 6)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 eosinophilia 55 31 hallmark (90%) Very frequent (99-80%) HP:0001880
2 follicular hyperplasia 55 31 hallmark (90%) Very frequent (99-80%) HP:0002729
3 increased ige level 55 31 hallmark (90%) Very frequent (99-80%) HP:0003212
4 lymphadenopathy 55 Frequent (79-30%)
5 abnormality of the salivary glands 55 Occasional (29-5%)
6 abnormal salivary gland morphology 31 occasional (7.5%) HP:0010286

MGI Mouse Phenotypes related to Kimura Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CCL11 CCL5 CCR3 IL33 IL4 IL5
2 immune system MP:0005387 9.5 CCL11 CCL5 CCR3 IL33 IL4 IL5
3 respiratory system MP:0005388 9.1 CCL11 CCR3 IL33 IL4 IL5 TSLP

Drugs & Therapeutics for Kimura Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Epithelioid Hemangioma of Bone And Soft Tissue Completed NCT03169595

Search NIH Clinical Center for Kimura Disease

Genetic Tests for Kimura Disease

Anatomical Context for Kimura Disease

MalaCards organs/tissues related to Kimura Disease:

38
Lymph Node, Skin, Salivary Gland, Bone, Breast, Colon, Brain

Publications for Kimura Disease

Articles related to Kimura Disease:

(show top 50) (show all 103)
# Title Authors Year
1
Basophils are increased and express increased levels of interleukin-4 in the parotid lesions of Kimura disease. ( 29094020 )
2017
2
Treatment of Kimura disease with mycophenolate mofetil monotherapy. ( 28932783 )
2017
3
Superficial Parotidectomy Plane for Debulking Surgery in Kimura Disease. ( 28468187 )
2017
4
Nephrotic syndrome during the tapering of oral steroids after pathological diagnosis of Kimura disease from a lacrimal gland mass: case report and review of 10 Japanese patients. ( 29279552 )
2017
5
Expression of the interleukin-21 and phosphorylated extracellular signal regulated kinase 1/2 in Kimura disease. ( 28108473 )
2017
6
Kimura disease of buccal region in a pediatric patient with nephrotic syndrome: A case report. ( 29310412 )
2017
7
Kimura Disease: A Rare Case Report From Himalayan Region. ( 29238694 )
2017
8
Superficial Parotidectomy Plane for Debulking Surgery in Kimura Disease. ( 28106687 )
2017
9
A Rare Case of Kimura Disease with Bilateral Parotid Involvement. ( 28946727 )
2017
10
Kimura disease in a Maori man with nephrotic syndrome. ( 27981775 )
2016
11
Kimura disease. No age or ethnicity limit. ( 26905356 )
2016
12
A case of refractory Kimura disease with a buccal bulky mass successfullyA treated with low-dose cyclosporine A: Report andA reviewA ofA the literature. ( 26666475 )
2016
13
Kimura disease as mimicker of lymphoma - A case report. ( 27728556 )
2016
14
Kimura Disease of the Breast - A Previously Undescribed Entity. ( 27058987 )
2016
15
Comparison of Local Recurrence Rate of Three Treatment Modalities for Kimura Disease. ( 26674917 )
2016
16
An Unusual Clinical Presentation of Kimura Disease Manifesting with a Typical Cephalocervical Lesion and an Atypical Subcutaneous Hip Mass Lesion. ( 27086824 )
2016
17
Kimura Disease Presenting as Forehead Soft Mass. ( 27100647 )
2016
18
Human Polyomavirus-6 Infecting Lymph Nodes of a Patient With an Angiolymphoid Hyperplasia With Eosinophilia or Kimura Disease. ( 26962076 )
2016
19
Eosinophilia and multiple lymphadenopathy: Kimura disease, a rare, but benign condition. ( 27581232 )
2016
20
Concurrent Kimura disease and lupus nephritis: A case report. ( 27741124 )
2016
21
Kimura disease accompanied with nephrotic syndrome in a 45-year-old male. ( 25928198 )
2015
22
Retrospective Multicentric Study of 25 Kimura Disease Patients: Emphasis on Therapeutics and Shared Features with Cutaneous IgG4-Related Disease. ( 26452023 )
2015
23
A mass under parotid gland: a patient with kimura disease. ( 25668110 )
2015
24
Kimura Disease Presenting As an Eyelid Mass in a Young Asian Male. ( 26080258 )
2015
25
Unusual Cause of Swelling in the Upper Limb: Kimura Disease. ( 26421119 )
2015
26
Pulmonary embolism as the initial clinical presentation of Kimura disease: case report and literature review. ( 25699606 )
2015
27
Kimura disease associated with severe visual dysfunction due to remarkable periorbital involvement. ( 26031497 )
2015
28
Paradoxical brain embolism associated with Kimura disease mimics watershed infarction. ( 25447210 )
2015
29
Kimura disease: A rare case of bilateral infra-auricular masses. ( 26831431 )
2015
30
Kimura Disease Mimicking an Aneurysm of the Radial Artery. ( 26362092 )
2015
31
Recurrent Kimura Disease of the Inner Canthus With No Lymphadenopathy. ( 26020715 )
2015
32
Kimura disease associated with IgA nephropathy. ( 24656163 )
2014
33
Kimura disease manifesting as synchronous bilateral parotid swelling in a young middle-eastern patient. ( 25544928 )
2014
34
Preliminary study of diffusion-weighted imaging and magnetic resonance spectroscopy imaging in kimura disease. ( 25377973 )
2014
35
Kimura Disease Simulating Hodgkin's Lymphoma on (18)F FDG PET-CT: Report of a Case. ( 26396638 )
2014
36
Kimura disease complicated with bowel infarction and multiple arterial thromboses in the extremities. ( 24356478 )
2014
37
The false-positive finding of left pulmonary Kimura disease on 18F-FDG PET/CT. ( 23510880 )
2013
38
Kimura disease involving a caruncle. ( 23543681 )
2013
39
Intraparotid Kimura disease. ( 23021002 )
2013
40
Kimura Disease of the Epiglottis: A Case Report and Review of Literature. ( 23907346 )
2013
41
Kimura Disease: rare cause of a slowly progressive orbital mass. ( 24119195 )
2013
42
Epitrochlear mass in a patient on maintenance hemodialysis--Kimura disease. ( 22280213 )
2012
43
Treatment of Kimura disease with photodynamic therapy: a case study. ( 22369733 )
2012
44
Kimura disease: CT and MR imaging findings. ( 22173767 )
2012
45
Kimura disease: diagnostic challenges and clinical management. ( 21763034 )
2012
46
Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with Kimura disease. ( 22627370 )
2012
47
Kimura disease: a case report and review of the literature with a new management protocol. ( 21423602 )
2011
48
Juvenile temporal arteritis with perifollicular lymphoid proliferation resembling Kimura disease. Report of a case. ( 21182505 )
2011
49
Microfilaria in lymph node mimicking Kimura disease. ( 23508372 )
2011
50
Kimura disease in children: a case report and a summary of the literature in Chinese. ( 21436734 )
2011

Variations for Kimura Disease

Expression for Kimura Disease

Search GEO for disease gene expression data for Kimura Disease.

Pathways for Kimura Disease

Pathways related to Kimura Disease according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 CCL11 CCL5 CCR3 IL4 IL5 TSLP
2
Show member pathways
13.11 CCL11 CCL5 CCR3 IL4 IL5
3
Show member pathways
13.04 CCL11 CCL5 IL33 IL4 IL5
4
Show member pathways
12.96 CCL11 CCL5 CCR3 IL4 IL5
5
Show member pathways
12.55 CCL11 IL4 IL5 RNASE3
6
Show member pathways
12.1 CCL11 CCL5 CCR3
7
Show member pathways
12.1 IL4 IL5 TSLP
8
Show member pathways
12.08 CCL11 IL4 IL5
9
Show member pathways
11.67 CCL11 CCL5 CCR3
10 11.64 CCR3 IL4 IL5
11 11.46 IL33 IL4 IL5 TSLP
12 11.34 CCL11 IL4 IL5
13 11.3 CCL5 IL4
14 11.12 IL4 IL5
15 11.12 CCL11 IL33 IL4 IL5
16 11.07 IL4 IL5
17 10.97 IL4 IL5
18 10.85 CCL11 CCL5 IL4 IL5
19 10.82 CCL11 CCL5 CCR3 IL4 IL5
20 10.76 IL33 IL4 IL5 TSLP
21 10.73 CCL11 CCL5 IL4 IL5
22 10.54 IL4 IL5

GO Terms for Kimura Disease

Cellular components related to Kimura Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL11 CCL5 IL33 IL4 IL5 RNASE3
2 extracellular space GO:0005615 9.17 CCL11 CCL5 IL33 IL4 IL5 RNASE3

Biological processes related to Kimura Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.78 CCL11 CCL5 IL4 IL5
2 inflammatory response GO:0006954 9.73 CCL11 CCL5 CCR3 IL5
3 neutrophil chemotaxis GO:0030593 9.57 CCL11 CCL5
4 positive regulation of T cell proliferation GO:0042102 9.56 CCL5 IL4
5 cellular defense response GO:0006968 9.55 CCR3 IL4
6 positive regulation of interleukin-6 production GO:0032755 9.54 IL33 TSLP
7 monocyte chemotaxis GO:0002548 9.52 CCL11 CCL5
8 positive regulation of B cell proliferation GO:0030890 9.51 IL4 IL5
9 positive regulation of JAK-STAT cascade GO:0046427 9.49 CCL5 IL5
10 positive regulation of immunoglobulin secretion GO:0051024 9.46 IL33 IL5
11 chemotaxis GO:0006935 9.46 CCL11 CCL5 CCR3 IL4
12 chemokine-mediated signaling pathway GO:0070098 9.43 CCL11 CCL5 CCR3
13 eosinophil chemotaxis GO:0048245 9.4 CCL11 CCL5
14 positive regulation of interleukin-5 production GO:0032754 9.37 IL33 TSLP
15 type 2 immune response GO:0042092 9.32 IL33 IL4
16 positive regulation of interleukin-13 production GO:0032736 9.13 IL33 IL4 TSLP
17 regulation of receptor activity GO:0010469 9.1 CCL11 CCL5 IL33 IL4 IL5 TSLP

Molecular functions related to Kimura Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL11 CCL5 IL33 IL4 IL5 TSLP
2 chemokine activity GO:0008009 8.96 CCL11 CCL5

Sources for Kimura Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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