MCID: KLN002
MIFTS: 46

Kleine-Levin Syndrome malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Mental diseases

Aliases & Classifications for Kleine-Levin Syndrome

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Sources:
10Disease Ontology, 46NINDS, 12DISEASES, 51Orphanet, 65UMLS, 45NIH Rare Diseases, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet, 61The Human Phenotype Ontology
See all MalaCards sources

Aliases & Descriptions for Kleine-Levin Syndrome:

Name: Kleine-Levin Syndrome 10 46 12 51 65
Familial Kleine-Levin Syndrome 45 65
Kleine-Levin Hibernation Syndrome 45
 
Familial Hibernation Syndrome 45
Kleine Levin Syndrome 45

Characteristics:

Orphanet epidemiological data:

51
kleine-levin syndrome:
Age of onset: Adolescent,Adult,Childhood


Classifications:



External Ids:

Disease Ontology10 DOID:0060165
Orphanet51 33543
ICD10 via Orphanet28 G47.8
MESH via Orphanet37 D017593
UMLS via Orphanet66 C0206085
UMLS65 C0206085, C2936703

Summaries for Kleine-Levin Syndrome

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NIH Rare Diseases:45 Kleine levin syndrome is a rare disorder characterized by episodes of excessive sleep. affected individuals may sleep for up to 20 hours per day during an episode. these episodes usually last for a few days to a few weeks. an episode may start abruptly and is sometimes associated with flu-like symptoms. during an episode, people with kleine levin syndrome can also display abnormal behavior, such as excessive food intake, irritability, childishness, disorientation, hallucinations, and an abnormally uninhibited sex drive. affected individuals do not experience any of these features between episodes, and they may not be able to remember everything that happened during an episode. the time between episodes varies among individuals with this condition. kleine levin syndrome primarily affects adolescent males, but it also affects females. it may be caused by abnormal function of the hypothalamus and thalamus, parts of the brain that control appetite and sleep. episodes usually decrease in frequency and intensity after about eight to 12 years. last updated: 3/2/2010

MalaCards based summary: Kleine-Levin Syndrome, also known as familial kleine-levin syndrome, is related to schizophrenia and lichen planus pemphigoides, and has symptoms including episodic hypersomnia, vivid hallucinations and polyphagia. An important gene associated with Kleine-Levin Syndrome is HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1), and among its related pathways are Neurotransmitter Clearance In The Synaptic Cleft and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. Affiliated tissues include brain, thalamus and hypothalamus, and related mouse phenotypes are muscle and endocrine/exocrine gland.

Disease Ontology:10 A recurrent hypersomnia that is characterized by recurring periods of excessive amounts of sleep and altered behavior.

NINDS:46 Kleine-Levin syndrome is a rare disorder that primarily affects adolescent males (approximately 70 percent of those with Kleine-Levin syndrome are male). It is characterized by recurring but reversible periods of excessive sleep (up to 20 hours per day). Symptoms occur as "episodes," typically lasting a few days to a few weeks. Episode onset is often abrupt, and may be associated with flu-like symptoms. Excessive food intake, irritability, childishness, disorientation, hallucinations, and an abnormally uninhibited sex drive may be observed during episodes. Mood can be depressed as a consequence, but not a cause, of the disorder. Affected individuals are completely normal between episodes, although they may not be able to remember afterwards everything that happened during the episode. It may be weeks or more before symptoms reappear. Symptoms may be related to malfunction of the hypothalamus and thalamus, parts of the brain that govern appetite and sleep.

Wikipedia:68 Kleine–Levin syndrome (KLS) also known as \"Sleeping Beauty syndrome\" is a rare sleep disorder... more...

Related Diseases for Kleine-Levin Syndrome

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Diseases related to Kleine-Levin Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia28.7COMT, GAD2, HCRT, HTR2A, HTR7, SLC6A3
2lichen planus pemphigoides10.9HLA-DQB1, HLA-DRB1
3tucker syndrome10.9HLA-DQB1, HLA-DRB1
4idiopathic inflammatory myopathy10.8HCRT, HLA-DQB1
5heavy chain deposition disease10.8HLA-DQB1, HLA-DRB1
6pulmonary coin lesion10.8HLA-DQB1, HLA-DRB1
7autoimmune polyglandular syndrome type 210.8HLA-DQB1, HLA-DRB1
8best1 retinopathy10.8HLA-DQB1, HLA-DRB1
9idiopathic juxtafoveal retinal telangiectasia10.8HLA-DQB1, HLA-DRB1
10non-distal monosomy 10q10.8HLA-DQB1, HLA-DRB1
11lichtenstein syndrome10.8HLA-DQB1, HLA-DRB1
12red cell phospholipid defect with hemolysis10.8HLA-DQB1, HLA-DRB1
13psoriasis10.8HLA-DQB1, HLA-DRB1
14actinomycosis10.8HLA-DQB1, HLA-DRB1
15finnish upper limb-onset distal myopathy10.7HLA-DQB1, HLA-DRB1
16hypersomnia10.7
17esophagus carcinoma in situ10.7HCRT, SLC6A3
18metanephric adenoma10.7HCRT, HLA-DQB1, HLA-DRB1
19hypertonia10.7HCRT, HLA-DQB1, HLA-DRB1
20rectal disease10.6HCRT, HLA-DQB1, HLA-DRB1
21nut allergy10.6HLA-DQB1, HLA-DRB1
22arterial calcification of infancy10.6RHCE, RHD
23pseudohypoparathyroidism10.6RHCE, RHD
24xerophthalmia10.6HTR2A, HTR7
25appendix lymphoma10.6RHCE, RHD
26liver leiomyoma10.6HTR2A, HTR7
27kluver-bucy syndrome10.6HTR2A, SLC6A3
28prostate adenocarcinoma10.5HTR2A, SLC6A3
29coronary thrombosis10.5HTR2A, HTR7
30cavernous sinus meningioma10.5HTR2A, TPH1
31uterine corpus adenomatoid tumor10.5HTR2A, SLC6A3
32encephalitis10.5
33ring chromosome 14 syndrome10.5COMT, HTR2A
34children's interstitial lung disease10.5COMT, TPH1
35steatorrhea10.5HTR2A, HTR7
36tympanosclerosis10.5HTR2A, HTR7
37neurodegeneration with optic atrophy, childhood onset10.5COMT, HTR2A
38intrahepatic cholestasis10.5COMT, HCRT
39marasmus10.4HTR2A, HTR7
40lymphocytic choriomeningitis10.4HLA-DQB1, HLA-DRB1
41moderately severe hemophilia a10.4HLA-DQB1, HLA-DRB1
42gastric pylorus carcinoma10.4HTR2A, HTR7, SLC6A3
43pyromania10.4HTR2A, HTR7, TPH1
44trichinosis10.3HTR2A, HTR7, TPH1
45retrograde amnesia10.3HTR2A, POMC
46kleptomania10.3HTR2A, SLC6A3
47atopic dermatitis10.3HCRT, HTR2A, SLC6A3
48perrault syndrome10.3COMT, HTR2A, SLC6A3
49autistic disorder10.3
50narcolepsy10.3

Graphical network of the top 20 diseases related to Kleine-Levin Syndrome:



Diseases related to kleine-levin syndrome

Symptoms for Kleine-Levin Syndrome

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HPO human phenotypes related to Kleine-Levin Syndrome:

id Description Frequency HPO Source Accession
1 episodic hypersomnia HP:0007200
2 vivid hallucinations HP:0006803
3 polyphagia HP:0002591
4 confusion HP:0001289

UMLS symptoms related to Kleine-Levin Syndrome:


sleep disturbances

Drugs & Therapeutics for Kleine-Levin Syndrome

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Brain Scintigraphy in Normal Versus Kleine-Levin Syndrome SubjectsCompletedNCT02337023

Search NIH Clinical Center for Kleine-Levin Syndrome

Genetic Tests for Kleine-Levin Syndrome

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Anatomical Context for Kleine-Levin Syndrome

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MalaCards organs/tissues related to Kleine-Levin Syndrome:

33
Brain, Thalamus, Hypothalamus, Testes, Lung, Prostate, Pituitary

Animal Models for Kleine-Levin Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Kleine-Levin Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3GAD2, HCRT, HLA-DQB1, HTR2A, RPS6KB2, SLC6A3
2MP:00053797.3COMT, CORT, GAD2, HLA-DQB1, HTR2A, POMC
3MP:00053866.7COMT, CORT, GAD2, HCRT, HLA-DQB1, HTR2A
4MP:00053765.7COMT, CORT, GAD2, HCRT, HLA-DQB1, HTR7

Publications for Kleine-Levin Syndrome

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Articles related to Kleine-Levin Syndrome:

(show top 50)    (show all 198)
idTitleAuthorsYear
1
Anti-N-Methyl-d-Aspartate Receptor Encephalitis Presenting With Features of Kleine-Levin Syndrome and Demyelination. (26922652)
2016
2
A "Sleeping Beauty" With a "Heart-Hand": Kleine-Levin Syndrome Treated With Buproprion and Carbamazepine in a Patient With Holt-Oram Syndrome. (27090505)
2016
3
Kleine-Levin syndrome. Familial cases and comparison with sporadic cases. (26739970)
2016
4
The Kleine-Levin Syndrome: A Rare Disease with Often Delayed Diagnosis-A Report of Two Cases in the Department of Neurology of the University Hospital of Cocody (CA'te d'Ivoire). (26989535)
2016
5
Lithium therapy in Kleine-Levin syndrome: An open-label, controlled study in 130 patients. (26453648)
2015
6
An unusual occurrence of Kleine-Levin syndrome in a man with refractory immune thrombocytopenic purpura: a case report. (25885480)
2015
7
Treatment of Kleine-Levin Syndrome with Aripiprazole. (26091200)
2015
8
Successful Use of Valproate in Kleine-Levin Syndrome: A Case Report and Review of Cases Reported from India. (26664089)
2015
9
Kleine-Levin syndrome with comorbid iron deficiency anemia. (26634130)
2015
10
Time to find a biomarker in Kleine-Levin Syndrome. (26459683)
2015
11
Feeling unreal: a functional imaging study in patients with Kleine-Levin syndrome. (24785943)
2014
12
Kleine-Levin Syndrome: A case report. (26483915)
2014
13
Functional magnetic resonance imaging in narcolepsy and the kleine-levin syndrome. (25009530)
2014
14
Treatment of kleine-levin syndrome with acetazolamide. (25317098)
2014
15
Transient Kleine-Levin syndrome following a neuroendoscopic procedure. (25093792)
2014
16
GAD65 autoantibodies in Kleine-Levin syndrome. (24763794)
2014
17
Kleine-Levin syndrome with brain atrophy. (23664128)
2013
18
Kleine-levin syndrome treated with clarithromycin. (24235906)
2013
19
Diagnosis, disease course, and management of patients with Kleine-Levin syndrome. (22995695)
2012
20
Kleine Levin syndrome in Malaysia: first typical case. (22605587)
2012
21
Kleine-Levin syndrome: the first typical case in Thailand. (21280539)
2010
22
Onset of Kleine-Levin Syndrome in association with isotretinoin treatment. (20163374)
2010
23
Working memory in 8 Kleine-Levin syndrome patients: an fMRI study. (19480235)
2009
24
Kleine-Levin syndrome: interface between neurology and psychiatry. (17420845)
2007
25
Posttraumatic Kleine-Levin syndrome. (16950384)
2006
26
Kleine-Levin syndrome: a systematic review of 186 cases in the literature. (16230322)
2005
27
The Kleine-Levin syndrome - effects of treatment with lithium -. (12910433)
2003
28
Short-term memory dysfunction in Kleine-Levin syndrome. (14616308)
2003
29
Clinical and polysomnographic characteristics of 34 patients with Kleine-Levin syndrome. (11903864)
2001
30
Kleine-levin syndrome : a report of two cases. (21407869)
2001
31
A case report of Kleine-Levin syndrome in an adolescent girl. (11496026)
2001
32
Neuropsychological sequelae in Kleine-Levin syndrome: case report. (10920418)
2000
33
Multiple sleep latency test and polysomnography in diagnosing Kleine-Levin syndrome and periodic hypersomnia. (11085556)
2000
34
Treatment of Kleine-Levin syndrome: melatonin on the starting block. (10817108)
2000
35
Light therapy for Kleine-Levin syndrome. (9847495)
1998
36
Kleine-Levin syndrome--a case report with a brief review. (9251261)
1996
37
Kleine-Levin syndrome in a boy with Prader-Willi syndrome. (8650457)
1996
38
Clinical use of moclobemide in Kleine-Levin syndrome. (1422635)
1992
39
Kleine-Levin syndrome: report of two cases with onset of symptoms precipitated by head trauma. (3139128)
1988
40
Kleine-levin syndrome: a case report from India. (6956423)
1982
41
A pathologic basis for Kleine-Levin syndrome. (6948538)
1982
42
Electrophysiological changes during episodes of the Kleine-Levin syndrome. (176325)
1975
43
The Kleine-Levin syndrome. Case report and review of the literature. (4814887)
1974
44
Periodic megaphagia and hypersomnia--an example of the Kleine-Levin syndrome in an adolescent girl. (4719411)
1973
45
A case of Kleine-Levin syndrome. (4721371)
1973
46
Kleine-Levin syndrome. A case with EEG evidence of periodic brain dysfunction. (5262037)
1970
47
Psychopathological investigation of a case of periodic hypersomnia and Bulimia (Kleine-Levin syndrome). (5235707)
1967
48
Kleine-Levin syndrome: report of a case. (6017827)
1967
49
The Kleine-Levin syndrome. Some further observations. (5295527)
1965
50
The Kleine-Levin syndrome: hypersomnia, bulimia, and abnormal mental states. (13896459)
1962

Variations for Kleine-Levin Syndrome

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Expression for genes affiliated with Kleine-Levin Syndrome

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Search GEO for disease gene expression data for Kleine-Levin Syndrome.

Pathways for genes affiliated with Kleine-Levin Syndrome

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GO Terms for genes affiliated with Kleine-Levin Syndrome

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Biological processes related to Kleine-Levin Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.3HLA-DQB1, HLA-DRB1
2nitrogen utilizationGO:001974010.3RHCE, RHD
3ammonium transmembrane transportGO:007248810.1RHCE, RHD
4organic cation transportGO:001569510.0RHCE, RHD
5smooth muscle contractionGO:00069399.8HTR2A, HTR7
6antigen processing and presentationGO:00198829.7HLA-DQB1, HLA-DRB1

Sources for Kleine-Levin Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet