MCID: KRN001
MIFTS: 42

Korean Hemorrhagic Fever

Categories: Nephrological diseases, Infectious diseases

Aliases & Classifications for Korean Hemorrhagic Fever

MalaCards integrated aliases for Korean Hemorrhagic Fever:

Name: Korean Hemorrhagic Fever 12 14
Hemorrhagic Fever with Renal Syndrome 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050200

Summaries for Korean Hemorrhagic Fever

Disease Ontology : 12 A hemorrhagic fever with renal syndrome that results_in infection located in kidney, has material basis in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has material basis in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has symptom headache, has symptom back pain, has symptom abdominal pain, has symptom fever, has symptom chills, has symptom nausea, has symptom blurred vision, has symptom flushing of the face, has symptom redness of the eyes, has symptom rash, has symptom low blood pressure, has symptom acute shock, has symptom vascular leakage, and has symptom acute kidney failure, which can cause severe fluid overload.

MalaCards based summary : Korean Hemorrhagic Fever, also known as hemorrhagic fever with renal syndrome, is related to hemorrhagic fever and disseminated intravascular coagulation, and has symptoms including headache, back pain and abdominal pain. An important gene associated with Korean Hemorrhagic Fever is NDUFA6 (NADH:Ubiquinone Oxidoreductase Subunit A6), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). The drugs Antibodies and Antibodies, Blocking have been mentioned in the context of this disorder. Affiliated tissues include kidney, kidney and eye, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Korean Hemorrhagic Fever

Diseases related to Korean Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 hemorrhagic fever 30.6 CD40LG F2 F3 SERPINC1
2 disseminated intravascular coagulation 29.3 F2 F3 PLG SERPINC1 SERPINF2
3 hemorrhagic fever with renal syndrome 11.5
4 cold urticaria 10.4 SERPINC1 SERPINF2
5 syphilitic meningitis 10.4 CD40LG SERPINC1
6 intracranial sinus thrombosis 10.4 F3 SERPINC1
7 japanese spotted fever 10.4 CD40LG SERPINC1
8 conjugate gaze palsy 10.4 F3 PLG
9 livedoid vasculopathy 10.4 CD40LG F2
10 spinal cord infarction 10.3 F2 SERPINC1
11 catastrophic antiphospholipid syndrome 10.3 CD40LG F3
12 sudden sensorineural hearing loss 10.3 F2 SERPINC1
13 blood protein disease 10.3 F2 SERPINC1
14 prothrombin deficiency, congenital 10.3 F2 SERPINC1
15 cerebral sinovenous thrombosis 10.3 F2 F3
16 ischemic colitis 10.3 F2 SERPINC1
17 acute cor pulmonale 10.3 PLG SERPINF2
18 monoclonal paraproteinemia 10.3 CD40LG VWF
19 dysbaric osteonecrosis 10.3 F3 PLG
20 acute poststreptococcal glomerulonephritis 10.3 NPPA PLG SERPINF2
21 alcohol-related birth defect 10.3 F2 F3
22 mitral valve stenosis 10.3 NPPA SERPINC1
23 sneddon syndrome 10.3 F2 SERPINC1
24 retinal artery occlusion 10.3 F2 SERPINC1
25 hepatitis d 10.3 CD40LG F2
26 esophageal varix 10.3 F2 SERPINC1
27 heparin-induced thrombocytopenia 10.2 CD40LG F3 SERPINC1
28 active peptic ulcer disease 10.2 F2 VWF
29 thrombophlebitis 10.2 F2 SERPINC1 SERPINF2
30 subendocardial myocardial infarction 10.2 F2 LDHA SERPINC1
31 factor xii deficiency 10.2 F3 SERPINC1
32 lemierre's syndrome 10.2 F3 PLG
33 platelet aggregation, spontaneous 10.2 SERPINC1 SERPINF2 VWF
34 basilar artery occlusion 10.2 F2 PLG
35 factor v deficiency 10.2 F2 F3
36 schistosomiasis 10.2 CD40LG F2 SERPINF2
37 factor viii deficiency 10.2 F2 VWF
38 hantavirus pulmonary syndrome 10.2 CD40LG F2 F3
39 splenic disease 10.2 CD40LG F2 F3
40 intermediate coronary syndrome 10.2 F3 PLG SERPINC1
41 sagittal sinus thrombosis 10.2 F2 F3 SERPINC1
42 factor xiii deficiency 10.2 F3 SERPINF2
43 hepatic veno-occlusive disease 10.1 F3 PLG SERPINC1
44 endocardium disease 10.1 CD40LG F2 F3
45 hepatic infarction 10.1 F2 F3 SERPINC1
46 prothrombin deficiency 10.1 F2 F3 SERPINC1
47 peripheral vertigo 10.1 F2 F3 SERPINC1
48 anterior spinal artery syndrome 10.1 F2 PLG SERPINC1
49 cerebral falx meningioma 10.1 F2 F3 PLG
50 factor xi deficiency 10.1 F2 F3 SERPINC1

Graphical network of the top 20 diseases related to Korean Hemorrhagic Fever:



Diseases related to Korean Hemorrhagic Fever

Symptoms & Phenotypes for Korean Hemorrhagic Fever

Symptoms:

12 (show all 14)
  • headache
  • back pain
  • abdominal pain
  • fever
  • chills
  • nausea
  • blurred vision
  • flushing of the face
  • redness of the eyes
  • rash
  • low blood pressure
  • acute shock
  • vascular leakage
  • acute kidney failure

MGI Mouse Phenotypes related to Korean Hemorrhagic Fever:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 CD40LG F2 F3 LDHA NPPA PLG
2 homeostasis/metabolism MP:0005376 9.32 CD40LG F2 F3 LDHA NPPA PLG

Drugs & Therapeutics for Korean Hemorrhagic Fever

Drugs for Korean Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 3
2 Antibodies, Blocking Phase 3
3 Immunoglobulins Phase 3
4 Vaccines Phase 3,Phase 2,Phase 1
5
Epinephrine Approved, Vet_approved Phase 2,Phase 1 51-43-4 5816
6 Racepinephrine Approved Phase 2,Phase 1 329-65-7
7
Ribavirin Approved Phase 2 36791-04-5 37542
8 Epinephryl borate Phase 2,Phase 1
9 Anti-Infective Agents Phase 2
10 Antimetabolites Phase 2
11 Antiviral Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Evalutate Long-term Immunity of Hantavax in High Risk Population of HFRS Completed NCT02360514 Phase 3 Hantavax injection
2 Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever Active, not recruiting NCT02116205 Phase 2
3 Ribavirin for Hemorrhagic Fever With Renal Syndrome Enrolling by invitation NCT00623168 Phase 2 Ribavirin
4 Ribavirin for Hemorrhagic Fever With Renal Syndrome in Germany Withdrawn NCT00868946 Phase 2 Virazole (Ribavirin)
5 Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines Completed NCT01502345 Phase 1
6 Diagnostic of Puumala Virus Infection in France Recruiting NCT02455375

Search NIH Clinical Center for Korean Hemorrhagic Fever

Genetic Tests for Korean Hemorrhagic Fever

Anatomical Context for Korean Hemorrhagic Fever

The Foundational Model of Anatomy Ontology organs/tissues related to Korean Hemorrhagic Fever:

18
Kidney

MalaCards organs/tissues related to Korean Hemorrhagic Fever:

38
Kidney, Eye, Testes

Publications for Korean Hemorrhagic Fever

Articles related to Korean Hemorrhagic Fever:

(show all 34)
# Title Authors Year
1
Bilateral Simultaneous Angle-closure Glaucoma Associated With Septic Condition of Korean Hemorrhagic Fever (KHF). ( 23429623 )
2013
2
Hemorrhagic fever with renal syndrome (HFRS, Korean hemorrhagic fever). ( 16983539 )
2007
3
Isolation of the etiologic agent of Korean hemorrhagic fever. 1978. ( 15517702 )
2004
4
Nucleotide sequence of nucleocapsid protein (N) of Hantaan virus isolated from a Korean hemorrhagic fever patient. ( 9524814 )
1997
5
Localization of Hantaan viral envelope glycoproteins by monoclonal antibodies in renal tissues from patients with Korean hemorrhagic fever H. ( 7692720 )
1993
6
Korean hemorrhagic fever: nursing care critical to recovery. ( 1673232 )
1991
7
Korean hemorrhagic fever: environmental health and medical surveillance measures. ( 1980148 )
1990
8
Plasma concentration of atrial natriuretic peptide in different phases of Korean hemorrhagic fever. ( 2563575 )
1989
9
Coagulopathy in hemorrhagic fever with renal syndrome (Korean hemorrhagic fever). ( 2568677 )
1989
10
Korean hemorrhagic fever. ( 2893250 )
1988
11
Leads from the MMWR. Korean hemorrhagic fever. ( 2893844 )
1988
12
Early ocular manifestations of Korean hemorrhagic fever. ( 2907359 )
1988
13
An explanation of renal hemodynamics in acute renal failure based on sequential CT in patients with Korean hemorrhagic fever. ( 2883204 )
1987
14
Procoagulant activity and thrombelastography in Korean hemorrhagic fever. ( 2908802 )
1986
15
Korean hemorrhagic fever: case report and observation on successful resuscitation of a patient with renal failure. ( 2873528 )
1986
16
Detection of hemagglutination-inhibiting antibodies in patients with nephropathia epidemica and Korean hemorrhagic fever by using Puumala virus cell culture antigen. ( 2871114 )
1986
17
Unique selective right atrial hemorrhage with epidemic (Korean) hemorrhagic fever. ( 6147078 )
1984
18
Disseminated intravascular coagulation in Korean hemorrhagic fever. ( 6141786 )
1983
19
Indirect immunofluorescence tests in Korean hemorrhagic fever and epidemic (endemic) nephropathia: treatment at low pH for removal of 'nonspecific' fluorescence in tissues from immunocompetent hosts. ( 6126464 )
1982
20
Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, from wild urban rats. ( 6127366 )
1982
21
Korean hemorrhagic fever. ( 6124025 )
1982
22
Laboratory-acquired infections with Hantaan virus, the etiologic agent of Korean hemorrhagic fever. ( 6127367 )
1982
23
Korean hemorrhagic fever: propagation of the etiologic agent in a cell line of human origin. ( 6110243 )
1981
24
Intraspecific transmission of Hantaan virus, etiologic agent of Korean hemorrhagic fever, in the rodent Apodemus agrarius. ( 6116436 )
1981
25
Observations on natural and laboratory infection of rodents with the etiologic agent of Korean hemorrhagic fever. ( 6786119 )
1981
26
Propagation of Korean hemorrhagic fever virus in laboratory rats. ( 6111538 )
1981
27
Korean hemorrhagic fever among rural residents in Japan. ( 6118386 )
1981
28
Nephropathia epidemica and Korean hemorrhagic fever: the veil lifted? ( 6102588 )
1980
29
Korean hemorrhagic fever. ( 6102082 )
1980
30
Etiological relation between Korean hemorrhagic fever and epidemic hemorrhagic fever in Japan. ( 43726 )
1979
31
Isolation of the etiologic agent of Korean Hemorrhagic fever. ( 24670 )
1978
32
Korean hemorrhagic fever. ( 28371 )
1978
33
Serum and urinary fibrin/fibrinogen degradation products in patients with Korean hemorrhagic fever; with particular reference to disseminated intravascular coagulation and acute renal failure. ( 4469703 )
1974
34
Accelerated intravascular coagulation in a patient with Korean hemorrhagic fever. ( 5645721 )
1968

Variations for Korean Hemorrhagic Fever

Expression for Korean Hemorrhagic Fever

Search GEO for disease gene expression data for Korean Hemorrhagic Fever.

Pathways for Korean Hemorrhagic Fever

GO Terms for Korean Hemorrhagic Fever

Cellular components related to Korean Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 F2 F3 LDHA LDHC PLG SERPINC1
2 extracellular space GO:0005615 9.87 CD40LG F2 F3 NPPA PLG SERPINC1
3 platelet alpha granule lumen GO:0031093 9.33 PLG SERPINF2 VWF
4 extracellular region GO:0005576 9.28 CD40LG F2 F3 NPPA PLG PRNT
5 blood microparticle GO:0072562 9.26 F2 PLG SERPINC1 SERPINF2

Biological processes related to Korean Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.63 PLG SERPINF2 VWF
2 cellular protein metabolic process GO:0044267 9.62 F2 NPPA PLG SERPINC1
3 blood coagulation GO:0007596 9.55 F2 F3 PLG SERPINC1 VWF
4 platelet activation GO:0030168 9.54 CD40LG F2 VWF
5 positive regulation of collagen biosynthetic process GO:0032967 9.51 F2 SERPINF2
6 regulation of blood coagulation GO:0030193 9.49 F2 SERPINC1
7 pyruvate metabolic process GO:0006090 9.48 LDHA LDHC
8 blood coagulation, intrinsic pathway GO:0007597 9.43 F2 VWF
9 fibrinolysis GO:0042730 9.43 F2 PLG SERPINF2
10 carboxylic acid metabolic process GO:0019752 9.4 LDHA LDHC
11 negative regulation of fibrinolysis GO:0051918 9.13 F2 PLG SERPINF2
12 hemostasis GO:0007599 9.02 F2 F3 PLG SERPINC1 VWF

Molecular functions related to Korean Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 L-lactate dehydrogenase activity GO:0004459 8.96 LDHA LDHC
2 protease binding GO:0002020 8.92 F3 SERPINC1 SERPINF2 VWF

Sources for Korean Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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