MCID: KRS005
MIFTS: 9

Korsakoff's Amnesic Syndrome

Aliases & Classifications for Korsakoff's Amnesic Syndrome

MalaCards integrated aliases for Korsakoff's Amnesic Syndrome:

Name: Korsakoff's Amnesic Syndrome 51
Alcohol Induced Encephalopathy 69

Summaries for Korsakoff's Amnesic Syndrome

NINDS : 51 Wernicke's encephalopathy is a degenerative brain disorder caused by the lack of thiamine (vitamin B1). It may result from alcohol abuse, dietary deficiencies, prolonged vomiting, eating disorders, or the effects of chemotherapy. B1 deficiency causes damage to the brain's thalamus and hypothalamus. Symptoms include mental confusion, vision problems, coma, hypothermia, low blood pressure, and lack of muscle coordination (ataxia). Korsakoff syndrome (also called Korsakoff's amnesic syndrome) is a memory disorder that results from vitamin B1 deficiency and is associated with alcoholism. Korsakoff's syndrome damages nerve cells and supporting cells in the brain and spinal cord, as well as the part of the brain involved with memory. Symptoms include amnesia, tremor, coma, disorientation, and vision problems, The disorder's main features are problems in acquiring new information or establishing new memories, and in retrieving previous memories. Although Wernicke's and Korsakoff's are related disorders, some scientists believe them to be different stages of the same disorder, which is called Wernicke-Korsakoff syndrome. Wernicke's encephalopathy represents the "acute" phase of the disorder and Korsakoff's amnesic syndrome represents the disorder progressing to a "chronic" or long-lasting stage.

MalaCards based summary : Korsakoff's Amnesic Syndrome, is also known as alcohol induced encephalopathy. The drugs Thiamine and Folic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, hypothalamus and spinal cord.

Related Diseases for Korsakoff's Amnesic Syndrome

Symptoms & Phenotypes for Korsakoff's Amnesic Syndrome

Drugs & Therapeutics for Korsakoff's Amnesic Syndrome

Drugs for Korsakoff's Amnesic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thiamine Approved, Nutraceutical, Vet_approved Phase 4 59-43-8 1130
2
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
3 Vitamins Phase 4
4 Micronutrients Phase 4
5 Trace Elements Phase 4
6 Vitamin B Complex Phase 4
7 Thiamin Nutraceutical Phase 4
8 Folate Nutraceutical Phase 4
9 Vitamin B9 Nutraceutical Phase 4
10 pyruvate Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Optimum Thiamine Intervention (OpTIn) Trial Recruiting NCT02788552 Phase 4 Thiamine Hydrochloride
2 From Uncomplicated Alcoholism to Korsakoff's Syndrome Unknown status NCT01455207

Search NIH Clinical Center for Korsakoff's Amnesic Syndrome

Genetic Tests for Korsakoff's Amnesic Syndrome

Anatomical Context for Korsakoff's Amnesic Syndrome

MalaCards organs/tissues related to Korsakoff's Amnesic Syndrome:

39
Brain, Hypothalamus, Spinal Cord, Thalamus

Publications for Korsakoff's Amnesic Syndrome

Articles related to Korsakoff's Amnesic Syndrome:

id Title Authors Year
1
Bilateral cavernous sinus thrombosis causing Korsakoff's amnesic syndrome. ( 7738577 )
1995
2
Cognitive brain potentials and psychological deficits in Alzheimer's dementia and Korsakoff's amnesic syndrome. ( 3602227 )
1987

Variations for Korsakoff's Amnesic Syndrome

Expression for Korsakoff's Amnesic Syndrome

Search GEO for disease gene expression data for Korsakoff's Amnesic Syndrome.

Pathways for Korsakoff's Amnesic Syndrome

GO Terms for Korsakoff's Amnesic Syndrome

Sources for Korsakoff's Amnesic Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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