MCID: KWS001
MIFTS: 34

Kwashiorkor

Categories: Metabolic diseases, Skin diseases

Aliases & Classifications for Kwashiorkor

MalaCards integrated aliases for Kwashiorkor:

Name: Kwashiorkor 12 42 14 69
Nutritional Oedema with Dyspigmentation of Skin and/or Hair 12
Nutritional Edema with Dyspigmentation of Skin and Hair 12
Kwashiokor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13579
ICD10 33 E40
ICD9CM 35 260
MeSH 42 D007732
UMLS 69 C0022806

Summaries for Kwashiorkor

MalaCards based summary : Kwashiorkor, also known as nutritional oedema with dyspigmentation of skin and/or hair, is related to marasmus and protein-energy malnutrition. An important gene associated with Kwashiorkor is ALB (Albumin). The drugs Sulfamethoxazole and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and testes.

Wikipedia : 72 Kwashiorkor is a form of severe protein–energy malnutrition characterized by edema, irritability,... more...

Related Diseases for Kwashiorkor

Diseases related to Kwashiorkor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
id Related Disease Score Top Affiliating Genes
1 marasmus 11.6
2 protein-energy malnutrition 10.0
3 pellagra 10.0
4 pancreatitis 9.9
5 thyroiditis 9.8
6 hepatitis 9.8
7 cystic fibrosis 9.8
8 anorexia nervosa 9.8
9 riboflavin deficiency 9.8
10 dermatitis 9.8
11 aminoaciduria 9.8
12 obesity 9.8
13 keratomalacia 9.7
14 tuberculosis 9.7
15 ariboflavinosis 9.7
16 megaloblastic anemia 9.7
17 liver disease 9.7
18 malaria 9.7
19 xerophthalmia 9.7
20 atopic dermatitis 9.7
21 tropical calcific pancreatitis 9.5
22 rickets 9.5
23 cerebritis 9.5
24 acrodermatitis enteropathica 9.5
25 heart disease 9.5
26 sickle cell anemia 9.5
27 nephrotic syndrome 9.5
28 peritonitis 9.5
29 drug addiction 9.5
30 diarrhea 9.5
31 congestive heart failure 9.5
32 herpes simplex 9.5
33 crohn's disease 9.5
34 pure red-cell aplasia 9.5
35 malignant histiocytosis 9.5
36 glycogen storage disease 9.5
37 cholestasis 9.5
38 measles 9.5
39 gastroenteritis 9.5
40 achalasia 9.5
41 macrocytic anemia 9.5
42 pulmonary embolism 9.5
43 neuroblastoma 9.5
44 rheumatic heart disease 9.5
45 acrodermatitis 9.5
46 noma 9.5
47 mucositis 9.5
48 enteropathica 9.5
49 leprosy 9.5
50 short bowel syndrome 9.5

Comorbidity relations with Kwashiorkor via Phenotypic Disease Network (PDN): (show all 14)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Chronic Kidney Failure
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Iron Deficiency Anemia Paralytic Ileus
Protein-Energy Malnutrition Respiratory Failure
Schizophreniform Disorder Swallowing Disorders

Graphical network of the top 20 diseases related to Kwashiorkor:



Diseases related to Kwashiorkor

Symptoms & Phenotypes for Kwashiorkor

Drugs & Therapeutics for Kwashiorkor

Drugs for Kwashiorkor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfamethoxazole Approved Phase 3 723-46-6 5329
2
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
3 Anti-Bacterial Agents Phase 3
4 Anti-Infective Agents Phase 3
5 Antimalarials Phase 3
6 Antiparasitic Agents Phase 3
7 Antiprotozoal Agents Phase 3
8 Renal Agents Phase 3
9 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
10
Lamivudine Approved, Investigational 134678-17-4 60825
11
Nevirapine Approved 129618-40-2 4463
12
Zidovudine Approved 30516-87-1 35370
13
Amoxicillin Approved, Vet_approved 26787-78-0 33613 2171
14
Cefdinir Approved 91832-40-5 6915944
15
Hydrocortisone Approved, Vet_approved 50-23-7 5754 657311
16 Antioxidants
17 Anti-HIV Agents
18 Antimetabolites
19 Anti-Retroviral Agents
20 Antiviral Agents
21 Cytochrome P-450 CYP3A Inducers
22 Nucleic Acid Synthesis Inhibitors
23 Reverse Transcriptase Inhibitors
24 Antibiotics, Antitubercular
25 Micronutrients
26 Trace Elements
27 Cortisol succinate
28 Hydrocortisone 17-butyrate 21-propionate
29 Hydrocortisone acetate
30 Anesthetics
31 Vitamins
32 alanine Nutraceutical
33 cysteine Nutraceutical
34 Whey Protein Nutraceutical
35 Soy Bean Nutraceutical

Interventional clinical trials:

(show all 25)

id Name Status NCT ID Phase Drugs
1 Reformulated F75 Milk to Treat Severe Acute Malnutrition Completed NCT02246296 Phase 2, Phase 3
2 Cotrimoxazole Prophylaxis in Severely Malnourished Children Completed NCT00934492 Phase 3 Cotrimoxazole dispersible tablet;Placebo dispersible tablet
3 Aromatic Amino Acid Metabolism in the Pathogenesis of Kwashiorkor Completed NCT00429351 Early Phase 1
4 Study of Antioxidants and Oxidants in Malnourished Children Completed NCT00069134
5 Effect of Protein Supplementation After Bariatric Surgery Completed NCT02001636 Resource Instant Protein 88;Resource Maltodextrin
6 Developmental Adaptation to an Obesogenic Environment Completed NCT02257593
7 Safety and Metabolic Study of Highly Active Antiretroviral Therapy (HAART) in Malnourished Children With HIV Completed NCT01529125 zidovudine, lamivudine, nevirapine
8 Pilot Study of PUFA-optimized RUTF for Severe Acute Malnutrition Completed NCT02053857 Amoxicillin
9 Effectiveness of Oral Antibiotics in the Treatment of Severe Acute Malnutrition Completed NCT01000298 Placebo;Amoxicillin;Cefdinir
10 Increase Protein Intake of Older Meal Service Clients With Readymade Protein-rich Meals and Foods Completed NCT03032237
11 Mothers Understand And Can do it - Mid Upper Arm Circumference Screening for Malnutrition Performed by Mothers Completed NCT01790815
12 Laparoscopic Revision From Biliopancreatic Diversion to Gastric Bypass Completed NCT01041456
13 Effect of a Complementary Food Supplement on Growth and Morbidity of Ghanaian Infants Completed NCT03181178
14 Characterizing the Gut Microbiota Alteration Associated With Severe Acute Malnutrition Completed NCT02413905
15 Laparoscopic Revision of Jejunoileal Bypass to Gastric Bypass Completed NCT01040533
16 Formative Research Study to Address Protein Intake in Children and Analysis of Breast Milk Nutrient Content in Mothers Recruiting NCT03140696
17 Protein Supplementation Impact On Body Muscle Mass And Fat Mass In Qataris Post Bariatric Surgery, Randomized Controlled Trials (Rct) Recruiting NCT03147456
18 Testing the Developmental Origins Hypothesis Recruiting NCT01545492
19 Single Anastomosis Duodeno-ileal Bypass With Sleeve Gastrectomy (SADI-S): A Prospective Cohort Study Recruiting NCT02792166
20 Intra Hemodialytic Oral Protein and Exercise (IHOPE) Active, not recruiting NCT01234441
21 Nutritional Rehabilitation in Senegalese HIV-infected Children and Adolescents Active, not recruiting NCT03101852
22 Loop Duodenal Switch Surgery in Morbidly Obese Patients Terminated NCT02671331
23 Bariatric Surgery for ESRD Patients vs Control Terminated NCT00580762
24 Effectiveness of Supplementary Feeding During Infection Among Moderately Malnourished Children Terminated NCT00890695
25 Effectiveness of Oral Albendazole in the Treatment of Severe Acute Malnutrition Withdrawn NCT01395381 Placebo;Albendazole

Search NIH Clinical Center for Kwashiorkor

Cochrane evidence based reviews: kwashiorkor

Genetic Tests for Kwashiorkor

Anatomical Context for Kwashiorkor

MalaCards organs/tissues related to Kwashiorkor:

39
Skin, Liver, Testes, Breast, Bone, Thyroid, Pancreas

Publications for Kwashiorkor

Articles related to Kwashiorkor:

(show top 50) (show all 571)
id Title Authors Year
1
Genome sequence and description of Anaeromassilibacillus senegalensis gen. nov., sp. nov., isolated from the gut of patient with kwashiorkor. ( 28289546 )
2017
2
A child with kwashiorkor misdiagnosed as atopic dermatitis. ( 28537869 )
2017
3
Anaeromassilibacillus senegalensis gen. nov., sp. nov., isolated from the gut of a child with kwashiorkor. ( 27330815 )
2016
4
Iatrogenic kwashiorkor after distal gastric bypass surgery: the consequences of receiving multinational treatment. ( 26908419 )
2016
5
Kwashiorkor: an unexpected complication to anorexia nervosa. ( 27852657 )
2016
6
Letter to the editor. Defence of my hypothesis that the oedema of kwashiorkor is caused by hypoalbuminaemia. ( 25975279 )
2015
7
Nutritional and other types of oedema, albumin, complex carbohydrates and the interstitium - a response to Malcolm Coulthard's hypothesis: Oedema in kwashiorkor is caused by hypo-albuminaemia. ( 25844980 )
2015
8
Effects of induced-kwashiorkor on salivary parameters in Wistar rats. ( 26937525 )
2015
9
Depression of neutrophil function followed by severe infection in a child with Marasmic Kwashiorkor. ( 26076789 )
2015
10
Antioxidant and Anti-Inflammatory Activities of Kenyan Leafy Green Vegetables, Wild Fruits, and Medicinal Plants with Potential Relevance for Kwashiorkor. ( 26236384 )
2015
11
A kwashiorkor case due to the use of an exclusive rice milk diet to treat atopic dermatitis. ( 26293684 )
2015
12
Dermatosis in children with oedematous malnutrition (Kwashiorkor): a review of the literature. ( 24661336 )
2014
13
Iatrogenic kwashiorkor developing after bypass surgery. ( 23659833 )
2014
14
Flaky paint dermatosis. Kwashiorkor. ( 24285001 )
2014
15
Hypothesis: oedema in kwashiorkor is caused by hypoalbuminaemia. ( 25223408 )
2014
16
Dermatitis and dangerous diets: a case of kwashiorkor. ( 24807070 )
2014
17
Secondary Kwashiorkor: A Rare Complication of Gastric Bypass Surgery. ( 25498166 )
2014
18
Diet and kwashiorkor: a prospective study from rural DR Congo. ( 24765584 )
2014
19
Improvised peritoneal dialysis in an 18-month-old child with severe acute malnutrition (kwashiorkor) and acute kidney injury: a case report. ( 23809461 )
2013
20
Kwashiorkor and the gut microbiota. ( 23635056 )
2013
21
Acute inpatient presentation of kwashiorkor: not just a diagnosis of the developing world. ( 22471276 )
2013
22
Gut microbiomes of Malawian twin pairs discordant for kwashiorkor. ( 23363771 )
2013
23
Decreased metabolism of 13C-caffeine via hepatic CYP1A2 in marasmus and kwashiorkor based on breath test. ( 24114907 )
2013
24
Prenatal factors contribute to the emergence of kwashiorkor or marasmus in severe undernutrition: evidence for the predictive adaptation model. ( 22558267 )
2012
25
Kwashiorkor and marasmus are both associated with impaired glucose clearance related to pancreatic I^-cell dysfunction. ( 22386944 )
2012
26
Kwashiorkor in India. 1955. ( 23045746 )
2012
27
Kwashiorkor. ( 23045745 )
2012
28
Cutaneous manifestations of kwashiorkor: a case report of an adult man after abdominal surgery. ( 22281907 )
2011
29
Using of WHO guidelines for the management of severe malnutrition to cases of marasmus and kwashiorkor in a Colombia children's hospital. ( 22072341 )
2011
30
Iatrogenic Kwashiorkor in three infants on a diet of rice beverages. ( 22122793 )
2011
31
Cutaneous presentation of kwashiorkor due to infantile Crohn's disease. ( 19352699 )
2010
32
Hartnup disease masked by kwashiorkor. ( 20824986 )
2010
33
Kwashiorkor from a severe dietary restriction in an 8-month infant in suburban Detroit, Michigan: case report and review of the literature. ( 20534082 )
2010
34
Cranial magnetic resonance imaging findings in kwashiorkor. ( 20128668 )
2010
35
Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries. ( 20393967 )
2010
36
INCAP studies of kwashiorkor and marasmus. ( 20461902 )
2010
37
75 years of Kwashiorkor in Africa. ( 20345016 )
2009
38
Reduced production of sulfated glycosaminoglycans occurs in Zambian children with kwashiorkor but not marasmus. ( 19116330 )
2009
39
Kwashiorkor: more hypothesis testing is needed to understand the aetiology of oedema. ( 20345018 )
2009
40
Hypo-phosphataemia in children under five years with kwashiorkor and marasmic kwashiorkor. ( 20499782 )
2009
41
Kwashiorkor and severe acute malnutrition in childhood. ( 18502289 )
2008
42
Kwashiorkor and severe acute malnutrition in childhood. ( 18502290 )
2008
43
A prospective assessment of food and nutrient intake in a population of Malawian children at risk for kwashiorkor. ( 17414147 )
2007
44
Kwashiorkor and an acrodermatitis enteropathica-like eruption after a distal gastric bypass surgical procedure. ( 17599860 )
2007
45
From kwashiorkor to nephrotic edema. ( 17198923 )
2007
46
Kwashiorkor--is it a dying disease? ( 17378286 )
2007
47
The quality of the diet in Malawian children with kwashiorkor and marasmus. ( 16881921 )
2006
48
Achalasia cardia presenting with Marasmic Kwashiorkor. ( 16741337 )
2006
49
Lipid kinetic differences between children with kwashiorkor and those with marasmus. ( 16762938 )
2006
50
Rice nightmare: Kwashiorkor in 2 Philadelphia-area infants fed Rice Dream beverage. ( 15858513 )
2005

Variations for Kwashiorkor

Expression for Kwashiorkor

Search GEO for disease gene expression data for Kwashiorkor.

Pathways for Kwashiorkor

GO Terms for Kwashiorkor

Sources for Kwashiorkor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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