MCID: KWS001
MIFTS: 40

Kwashiorkor malady

Categories: Metabolic diseases, Skin diseases

Aliases & Classifications for Kwashiorkor

Aliases & Descriptions for Kwashiorkor:

Name: Kwashiorkor 12 42 14 69
Nutritional Oedema with Dyspigmentation of Skin and/or Hair 12
Nutritional Edema with Dyspigmentation of Skin and Hair 12
Kwashiokor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13579
ICD10 33 E40
ICD9CM 35 260
MeSH 42 D007732
UMLS 69 C0022806

Summaries for Kwashiorkor

MalaCards based summary : Kwashiorkor, also known as nutritional oedema with dyspigmentation of skin and/or hair, is related to megaloblastic anemia and marasmus. An important gene associated with Kwashiorkor is ALB (Albumin), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Sulfamethoxazole and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and testes.

Wikipedia : 71 Kwashiorkor is a form of severe protein–energy malnutrition characterized by edema, irritability,... more...

Related Diseases for Kwashiorkor

Diseases related to Kwashiorkor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
id Related Disease Score Top Affiliating Genes
1 megaloblastic anemia 29.8 GPT SLC17A5
2 marasmus 11.6
3 gastric neuroendocrine tumor type 1 10.2 GPT SLC17A5
4 radiation induced cancer 10.2 GPT SLC17A5
5 phaeochromocytoma 10.2 ALB TTR
6 basal ganglia cerebrovascular disease 10.2 ALB SHBG
7 ehlers-danlos syndrome, periodontal type 1 10.2 ALB TTR
8 familial progressive cardiac conduction defect 10.2 ALB LCAT
9 inner ear disease 10.2 ALB TTR
10 cataract 10.2 ALB TTR
11 congenital nonspherocytic hemolytic anemia 10.2 ALB TTR
12 isolated growth hormone deficiency 10.2 ALB GPT
13 erythema infectiosum 10.2 ALB TTR
14 peripheral vascular disease 10.2 ALB TTR
15 nondystrophic myotonia 10.2 ALB F2
16 hemopericardium 10.2 ALB TTR
17 freiberg's disease 10.2 ALB F2
18 pharynx carcinoma in situ 10.2 ALB F2
19 familial progressive hyperpigmentation 10.2 F2 GPT
20 duane retraction syndrome 10.2 ALB F2
21 chronic inflammatory demyelinating polyneuritis 10.1 ALB F2
22 angelucci's syndrome 10.1 ALB F2
23 stone in bladder diverticulum 10.1 ALB LCAT
24 ovarian papillary cystadenoma 10.1 ALB F2
25 maxillary sinusitis 10.1 F2 GPT
26 myopia 10.1 ALB F2
27 eagle syndrome 10.1 ALB F2
28 not otherwise specified 3-mga-uria type 10.1 GPT SLC17A5
29 aortic valve prolapse 10.1 ALB TTR
30 anaplastic ganglioglioma 10.1 LCAT TTR
31 atrophic vulva 10.1 ALB F2
32 borderline leprosy 10.1 ALB GPT
33 rosacea 10.1 ALB GPT SLC17A5
34 capillary hemangioma 10.1 ALB F2
35 pulpitis 10.1 F2 SLC17A5
36 coronary artery dissection, spontaneous 10.1 ALB TF
37 alcoholic gastritis 10.1 ALB F2
38 cerebral sarcoidosis 10.1 ALB TF
39 ischemic optic neuropathy 10.1 ALB F2
40 whipple disease 10.0 ALB TF
41 body dysmorphic disorder 10.0 ALB SHBG TTR
42 bile duct cystadenocarcinoma 10.0 ALB F2 GPT
43 malignant hyperthermia susceptibility 1 10.0 ALB TF
44 benign deep fibrous histiocytoma 10.0 ALB F2 GPT
45 hemolytic-uremic syndrome 10.0 ALB F2 GPT
46 pyelitis 10.0 ALB F2 GPT
47 fallopian tube leiomyosarcoma 10.0 ALB F2 GPT
48 gastrointestinal adenoma 10.0 ALB F2 GPT
49 episcleritis periodica fugax 10.0 GPT TF
50 fiedler's myocarditis 10.0 ALB F2 GPT

Comorbidity relations with Kwashiorkor via Phenotypic Disease Network (PDN): (show all 14)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Chronic Kidney Failure
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Iron Deficiency Anemia Paralytic Ileus
Protein-Energy Malnutrition Respiratory Failure
Schizophreniform Disorder Swallowing Disorders

Graphical network of the top 20 diseases related to Kwashiorkor:



Diseases related to Kwashiorkor

Symptoms & Phenotypes for Kwashiorkor

Drugs & Therapeutics for Kwashiorkor

Drugs for Kwashiorkor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfamethoxazole Approved Phase 3 723-46-6 5329
2
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
3 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
4 Anti-Bacterial Agents Phase 3
5 Anti-Infective Agents Phase 3
6 Antimalarials Phase 3
7 Renal Agents Phase 3
8 Antiparasitic Agents Phase 3
9 Antiprotozoal Agents Phase 3
10 Antioxidants Phase 1
11 alanine Nutraceutical Phase 1
12 cysteine Nutraceutical Phase 1
13
Nevirapine Approved 129618-40-2 4463
14
Zidovudine Approved 30516-87-1 35370
15
Lamivudine Approved, Investigational 134678-17-4 60825
16
Amoxicillin Approved, Vet_approved 26787-78-0 33613 2171
17
Cefdinir Approved 91832-40-5 6915944
18
Hydrocortisone Approved, Vet_approved 50-23-7 5754 657311
19
Hydroxocobalamin Approved 13422-51-0 11953898 5460373 44475014
20
Pyridoxine Approved, Nutraceutical, Vet_approved 65-23-6 1054
21
Niacin Approved, Investigational, Nutraceutical 59-67-6 938
22
Vitamin A Approved, Nutraceutical, Vet_approved 11103-57-4, 68-26-8 445354
23
leucovorin Approved, Nutraceutical 58-05-9 54575, 6560146 143
24
Biotin Approved, Nutraceutical 58-85-5 171548
25
Riboflavin Approved, Nutraceutical, Vet_approved 83-88-5 493570
26
Nicotinamide Approved, Nutraceutical 98-92-0 936
27
Thiamine Approved, Nutraceutical, Vet_approved 59-43-8 1130
28
Pyridoxal Approved, Nutraceutical 66-72-8 1050
29
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
30
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
31 Cytochrome P-450 CYP3A Inducers
32 Nucleic Acid Synthesis Inhibitors
33 Anti-HIV Agents
34 Antimetabolites
35 Anti-Retroviral Agents
36 Antibiotics, Antitubercular
37 Reverse Transcriptase Inhibitors
38 Antiviral Agents
39 Cortisol succinate
40 Trace Elements
41 Hydrocortisone 17-butyrate 21-propionate
42 Hydrocortisone acetate
43 Micronutrients
44 Nicotinic Acids
45 Anesthetics
46 Vitamin B 12
47 Vitamin B 6
48 Vitamin B Complex
49 Vitamins
50 Retinol palmitate

Interventional clinical trials:

(show all 25)
id Name Status NCT ID Phase
1 Reformulated F75 Milk to Treat Severe Acute Malnutrition Completed NCT02246296 Phase 2, Phase 3
2 Cotrimoxazole Prophylaxis in Severely Malnourished Children Completed NCT00934492 Phase 3
3 Study of Antioxidants and Oxidants in Malnourished Children Unknown status NCT00069134 Phase 1
4 Aromatic Amino Acid Metabolism in the Pathogenesis of Kwashiorkor Completed NCT00429351 Early Phase 1
5 Effect of Protein Supplementation After Bariatric Surgery Completed NCT02001636
6 Developmental Adaptation to an Obesogenic Environment Completed NCT02257593
7 Safety and Metabolic Study of Highly Active Antiretroviral Therapy (HAART) in Malnourished Children With HIV Completed NCT01529125
8 Pilot Study of PUFA-optimized RUTF for Severe Acute Malnutrition Completed NCT02053857
9 Effectiveness of Oral Antibiotics in the Treatment of Severe Acute Malnutrition Completed NCT01000298
10 Mothers Understand And Can do it - Mid Upper Arm Circumference Screening for Malnutrition Performed by Mothers Completed NCT01790815
11 Laparoscopic Revision From Biliopancreatic Diversion to Gastric Bypass Completed NCT01041456
12 Effect of a Complementary Food Supplement on Growth and Morbidity of Ghanaian Infants Completed NCT03181178
13 Characterizing the Gut Microbiota Alteration Associated With Severe Acute Malnutrition Completed NCT02413905
14 Laparoscopic Revision of Jejunoileal Bypass to Gastric Bypass Completed NCT01040533
15 Formative Research Study to Address Protein Intake in Children and Analysis of Breast Milk Nutrient Content in Mothers Recruiting NCT03140696
16 Protein Supplementation Impact On Body Muscle Mass And Fat Mass In Qataris Post Bariatric Surgery, Randomized Controlled Trials (Rct) Recruiting NCT03147456
17 Testing the Developmental Origins Hypothesis Recruiting NCT01545492
18 Single Anastomosis Duodeno-ileal Bypass With Sleeve Gastrectomy (SADI-S): A Prospective Cohort Study Recruiting NCT02792166
19 Intra Hemodialytic Oral Protein and Exercise (IHOPE) Active, not recruiting NCT01234441
20 Nutritional Rehabilitation in Senegalese HIV-infected Children and Adolescents Active, not recruiting NCT03101852
21 Increase Protein Intake of Older Meal Service Clients With Readymade Protein-rich Meals and Foods Not yet recruiting NCT03032237
22 Loop Duodenal Switch Surgery in Morbidly Obese Patients Terminated NCT02671331
23 Bariatric Surgery for ESRD Patients vs Control Terminated NCT00580762
24 Effectiveness of Supplementary Feeding During Infection Among Moderately Malnourished Children Terminated NCT00890695
25 Effectiveness of Oral Albendazole in the Treatment of Severe Acute Malnutrition Withdrawn NCT01395381

Search NIH Clinical Center for Kwashiorkor

Cochrane evidence based reviews: kwashiorkor

Genetic Tests for Kwashiorkor

Anatomical Context for Kwashiorkor

MalaCards organs/tissues related to Kwashiorkor:

39
Skin, Liver, Testes, Bone, Thyroid, Neutrophil, Heart

Publications for Kwashiorkor

Articles related to Kwashiorkor:

(show top 50) (show all 569)
id Title Authors Year
1
Anaeromassilibacillus senegalensis gen. nov., sp. nov., isolated from the gut of a child with kwashiorkor. ( 27330815 )
2016
2
Kwashiorkor: an unexpected complication to anorexia nervosa. ( 27852657 )
2016
3
Iatrogenic kwashiorkor after distal gastric bypass surgery: the consequences of receiving multinational treatment. ( 26908419 )
2016
4
Letter to the editor. Defence of my hypothesis that the oedema of kwashiorkor is caused by hypoalbuminaemia. ( 25975279 )
2015
5
Depression of neutrophil function followed by severe infection in a child with Marasmic Kwashiorkor. ( 26076789 )
2015
6
Nutritional and other types of oedema, albumin, complex carbohydrates and the interstitium - a response to Malcolm Coulthard's hypothesis: Oedema in kwashiorkor is caused by hypo-albuminaemia. ( 25844980 )
2015
7
Antioxidant and Anti-Inflammatory Activities of Kenyan Leafy Green Vegetables, Wild Fruits, and Medicinal Plants with Potential Relevance for Kwashiorkor. ( 26236384 )
2015
8
A kwashiorkor case due to the use of an exclusive rice milk diet to treat atopic dermatitis. ( 26293684 )
2015
9
Effects of induced-kwashiorkor on salivary parameters in Wistar rats. ( 26937525 )
2015
10
Dermatitis and dangerous diets: a case of kwashiorkor. ( 24807070 )
2014
11
Dermatosis in children with oedematous malnutrition (Kwashiorkor): a review of the literature. ( 24661336 )
2014
12
Flaky paint dermatosis. Kwashiorkor. ( 24285001 )
2014
13
Hypothesis: oedema in kwashiorkor is caused by hypoalbuminaemia. ( 25223408 )
2014
14
Diet and kwashiorkor: a prospective study from rural DR Congo. ( 24765584 )
2014
15
Secondary Kwashiorkor: A Rare Complication of Gastric Bypass Surgery. ( 25498166 )
2014
16
Iatrogenic kwashiorkor developing after bypass surgery. ( 23659833 )
2014
17
Gut microbiomes of Malawian twin pairs discordant for kwashiorkor. ( 23363771 )
2013
18
Improvised peritoneal dialysis in an 18-month-old child with severe acute malnutrition (kwashiorkor) and acute kidney injury: a case report. ( 23809461 )
2013
19
Decreased metabolism of 13C-caffeine via hepatic CYP1A2 in marasmus and kwashiorkor based on breath test. ( 24114907 )
2013
20
Acute inpatient presentation of kwashiorkor: not just a diagnosis of the developing world. ( 22471276 )
2013
21
Kwashiorkor and the gut microbiota. ( 23635056 )
2013
22
Prenatal factors contribute to the emergence of kwashiorkor or marasmus in severe undernutrition: evidence for the predictive adaptation model. ( 22558267 )
2012
23
Kwashiorkor. ( 23045745 )
2012
24
Kwashiorkor in India. 1955. ( 23045746 )
2012
25
Kwashiorkor and marasmus are both associated with impaired glucose clearance related to pancreatic I^-cell dysfunction. ( 22386944 )
2012
26
Using of WHO guidelines for the management of severe malnutrition to cases of marasmus and kwashiorkor in a Colombia children's hospital. ( 22072341 )
2011
27
Iatrogenic Kwashiorkor in three infants on a diet of rice beverages. ( 22122793 )
2011
28
Cutaneous manifestations of kwashiorkor: a case report of an adult man after abdominal surgery. ( 22281907 )
2011
29
Kwashiorkor from a severe dietary restriction in an 8-month infant in suburban Detroit, Michigan: case report and review of the literature. ( 20534082 )
2010
30
INCAP studies of kwashiorkor and marasmus. ( 20461902 )
2010
31
Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries. ( 20393967 )
2010
32
Hartnup disease masked by kwashiorkor. ( 20824986 )
2010
33
Cranial magnetic resonance imaging findings in kwashiorkor. ( 20128668 )
2010
34
Cutaneous presentation of kwashiorkor due to infantile Crohn's disease. ( 19352699 )
2010
35
75 years of Kwashiorkor in Africa. ( 20345016 )
2009
36
Kwashiorkor: more hypothesis testing is needed to understand the aetiology of oedema. ( 20345018 )
2009
37
Reduced production of sulfated glycosaminoglycans occurs in Zambian children with kwashiorkor but not marasmus. ( 19116330 )
2009
38
Hypo-phosphataemia in children under five years with kwashiorkor and marasmic kwashiorkor. ( 20499782 )
2009
39
Kwashiorkor and severe acute malnutrition in childhood. ( 18502289 )
2008
40
Kwashiorkor and severe acute malnutrition in childhood. ( 18502290 )
2008
41
Kwashiorkor and an acrodermatitis enteropathica-like eruption after a distal gastric bypass surgical procedure. ( 17599860 )
2007
42
From kwashiorkor to nephrotic edema. ( 17198923 )
2007
43
A prospective assessment of food and nutrient intake in a population of Malawian children at risk for kwashiorkor. ( 17414147 )
2007
44
Kwashiorkor--is it a dying disease? ( 17378286 )
2007
45
The quality of the diet in Malawian children with kwashiorkor and marasmus. ( 16881921 )
2006
46
Achalasia cardia presenting with Marasmic Kwashiorkor. ( 16741337 )
2006
47
Lipid kinetic differences between children with kwashiorkor and those with marasmus. ( 16762938 )
2006
48
Antioxidant supplementation for the prevention of kwashiorkor in Malawian children: randomised, double blind, placebo controlled trial. ( 15851401 )
2005
49
Rice nightmare: Kwashiorkor in 2 Philadelphia-area infants fed Rice Dream beverage. ( 15858513 )
2005
50
Effects of antioxidants on glutathione levels and clinical recovery from the malnutrition syndrome kwashiorkor--a pilot study. ( 16259789 )
2005

Variations for Kwashiorkor

Expression for Kwashiorkor

Search GEO for disease gene expression data for Kwashiorkor.

Pathways for Kwashiorkor

Pathways related to Kwashiorkor according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.44 ALB F2 TTR

GO Terms for Kwashiorkor

Cellular components related to Kwashiorkor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 ALB F2 LCAT SHBG TF TTR
2 endoplasmic reticulum lumen GO:0005788 9.5 ALB F2 TF
3 extracellular exosome GO:0070062 9.5 ALB F2 GPT LCAT SHBG TF
4 blood microparticle GO:0072562 9.43 ALB F2 TF
5 extracellular space GO:0005615 9.1 ALB F2 GPT LCAT TF TTR

Biological processes related to Kwashiorkor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 lipoprotein metabolic process GO:0042157 9.26 ALB LCAT
2 retina homeostasis GO:0001895 9.16 ALB TF
3 high-density lipoprotein particle remodeling GO:0034375 8.96 ALB LCAT
4 cellular protein metabolic process GO:0044267 8.92 ALB F2 TF TTR

Molecular functions related to Kwashiorkor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 8.62 ALB GPT

Sources for Kwashiorkor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....