MCID: LBY004
MIFTS: 53

Labyrinthitis malady

Ear diseases category

Summaries for Labyrinthitis

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Labyrinthitis is an ailment of the inner ear[dead link] and a form of unilateral vestibular dysfunction.... more...

MalaCards: Labyrinthitis, also known as labyrinthitis, unspecified, is related to anorexia nervosa and encephalitis. An important gene associated with Labyrinthitis is EPB41 (erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)), and among its related pathways are Neuroscience and "Ca, cAMP and Lipid Signaling". The compounds norepinephrine and dopamine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and brain, and related mouse phenotypes are nervous system and growth/size.

Disease Ontology:8 A inner ear infectious disease which involves inflammation of the labyrinths.

Aliases & Classifications for Labyrinthitis

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


Aliases & Descriptions:

labyrinthitis 8 10
labyrinthitis, unspecified 8
unspecified labyrinthitis 8
labyrinthine disorder 60
labyrinthitis nos 8


External Ids:

Disease Ontology8 DOID:1468
ICD9CM27 386.30, 386.3
MeSH34 D007762
ICD1025 H83.0

Related Diseases for Labyrinthitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Labyrinthitis family:

Viral Labyrinthitis

Diseases related to Labyrinthitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1anorexia nervosa29.8NPY, HTR3A
2encephalitis29.8CALB1
3panic disorder29.8HTR3A
4meningitis10.5
5viral labyrinthitis10.5
6otitis media10.5
7purulent labyrinthitis10.4
8serous labyrinthitis10.3
9toxic labyrinthitis10.3
10focal labyrinthitis10.3
11cholesteatoma10.2
12suppurative otitis media10.2
13sensorineural hearing loss10.2
14mumps10.2
15unilateral hyperactive labyrinth10.1
16bilateral hypoactive labyrinth10.1
17bilateral hyperactive labyrinth10.1
18chronic meningitis10.1
19cerebritis10.0
20unilateral hypoactive labyrinth10.0
21purulent acute otitis media10.0
22herpes simplex10.0
23influenza10.0
24meniere's disease10.0
25pneumonia10.0
26vestibular disease10.0
27benign paroxysmal positional nystagmus10.0
28schizophrenia10.0CALB1, HTR3A, NPY, NPAS3, NCS1, CHAT
29myocardial infarction10.0HTR3A, NPY, MAPK14, F3, ADRB1
30malignant glioma10.0HTR3A, NPY, CHAT, MAPK14, ADRB1
31vascular disease10.0CA1, MAPK14, IL10, F3
32prion disease10.0CALB1, NPY, CHAT, F3
33coronary artery disease10.0HTR3A, MAPK14, F3, ADRB1
34parkinson's disease10.0CALB1, HTR3A, CHAT, MAPK14
35cadasil10.0HTR3A, CHAT, F3, ADRB1
36dementia10.0MAPK14, CHAT, HTR3A
37neuroepithelioma10.0ADRB1, CHAT, NPY
38acute myocardial infarction10.0HTR3A, F3, ADRB1
39septic shock10.0F3, IL10, MAPK14
40ischemia10.0MAPK14, CHAT
41respiratory failure10.0F3, NPY
42down syndrome10.0SLC5A3, CHAT
43cholera10.0CHAT, HTR3A
44huntington's disease10.0CALB1, NPY, CHAT
45hypertension10.0ADRB1, NPY
46fibromyalgia10.0NPY, HTR3A
47multiple system atrophy10.0CHAT
48amnestic disorder10.0CHAT, HTR3A
49hyperglycemia10.0NPY
50myasthenia gravis10.0IL10

Graphical network of the top 20 diseases related to Labyrinthitis:



Diseases related to labyrinthitis

Clinical Features for Labyrinthitis

About this section

Drugs & Therapeutics for Labyrinthitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Labyrinthitis

Drug clinical trials:

Search ClinicalTrials for Labyrinthitis

Search NIH Clinical Center for Labyrinthitis

Search CenterWatch for Labyrinthitis

Genetic Tests for Labyrinthitis

About this section

Anatomical Context for Labyrinthitis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Labyrinthitis:

32
Bone, Testes, Brain, Endothelial, Bone marrow

Animal Models for Labyrinthitis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Labyrinthitis:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363112.5MAPK14, IL10, F3, SLC5A3, GSC, CHAT
2MP:000537812.4NPY, HTR3A, GCM1, F3, NPAS3, HAND1
3MP:001076812.4NPAS3, F3, IL10, HOXA13, MAPK14, CHAT
4MP:000537612.2NPAS3, IL10, F3, SLC5A3, EPB41, MAPK14
5MP:000538512.0GSC, NPAS3, HAND1, CHAT, MAPK14, HOXA13
6MP:000538611.9GSC, F3, IL10, POU3F4, CRLF1, NPAS3
7MP:000536911.7GSC, HTR3A, MAPK14, CHAT, HAND1, IL10
8MP:000539011.5NPY, ADRB1, IL10, HOXA13, MAPK14, POU3F4
9MP:000287311.4GCM1, NPY, HAND1, CHAT, MAPK14, F3
10MP:001077111.3F3, MAPK14, HTR3A, POU3F4, GSC, HOXA13
11MP:000538011.1GCM1, HAND1, MAPK14, HOXA13, IL10, F3

Publications for Labyrinthitis

About this section
Sources:
50PubMed
See all sources

Articles related to Labyrinthitis:

(show top 50)    (show all 214)
idTitleAuthorsYear
1
Geometrical and volume changes of the membranous vestibular labyrinth in guinea pigs with endolymphatic hydrops. (23817074)
2013
2
Pharmacogenetic labyrinth of neovascular age-related macular degeneration therapy: how to escape and move forward? (23930669)
2013
3
A rat in the labyrinth of anorexia nervosa: contributions of the activity-based anorexia rodent model to the understanding of anorexia nervosa. (23354987)
2013
4
End-stage labyrinthitis with extensive erosion of the bony labyrinth. (22377652)
2012
5
Acute labyrinthitis secondary to aural tick infestation. (23077807)
2012
6
Labyrinthitis ossificans secondary to autoimmune inner ear disease: a previously unreported condition. (20416474)
2010
7
Labyrinthitis ossificans: how accurate is MRI in predicting cochlear obstruction? (19393413)
2009
8
Labyrinthitis ossificans in a child with sickle cell disease: CT and MRI findings. (19415252)
2009
9
Labyrinthitis related to Wegener granulomatosis: magnetic resonance imaging findings. (18097336)
2008
10
Schizopsychotic symptom-profiles and biomarkers: beacons in diagnostic labyrinths. (19073416)
2008
11
Induction of cytomegalovirus-infected labyrinthitis in newborn mice by lipopolysaccharide: a model for hearing loss in congenital CMV infection. (18475257)
2008
12
Otogenic cerebellar abscess due to purulent labyrinthitis and defect of the superior semicircular canal and its propagation through the endolymphatic sac. (17372752)
2007
13
Otitis interna (labyrinthitis) associated with Salmonella enterica arizonae in turkey poults. (16617998)
2006
14
A case of tympanogenic labyrinthitis complicated by acute otitis media. (15744821)
2005
15
Mondini dysplasia of the bony and membranous labyrinth. (15699735)
2005
16
Localization of beta1-adrenergic receptors in the cochlea and the vestibular labyrinth. (15635809)
2004
17
Location and timing of initial osteoid deposition in postmeningitic labyrinthitis ossificans determined by multiple fluorescent labels. (15064623)
2004
18
Case report: explantation of a cochlear implant secondary to chronic granulating labyrinthitis. (18792151)
2003
19
Hypotonia, congenital hearing loss, and hypoactive labyrinths. (12731641)
2003
20
Labyrinthitis ossificans. (11605566)
2001
21
Th1: mediator lymphocytes in experimental autoimmune labyrinthitis. (11678165)
2001
22
Passive transfer of experimental autoimmune labyrinthitis. (10899699)
2000
23
Serum antibodies against membranous labyrinth in patients with "idiopathic" bilateral vestibulopathy. (9553841)
1998
24
MR imaging of intralabyrinthine schwannoma, labyrinthitis, and other labyrinthine pathology. (7675462)
1995
25
Suppurative labyrinthitis caused by anaerobic bacteria. (8035121)
1994
26
Labyrinthitis ossificans. (8238767)
1993
27
Evidence of direct communication of bone marrow cells with the endolymphatic sac in experimental autoimmune labyrinthitis. (8475730)
1993
28
Noci-autonomic-affective automatism, the physiopathological essence of hemicrania. The serotonin theory as a guiding principle in the labyrinth of interpretations]. (1297400)
1992
29
Bacterial tympanogenic labyrinthitis, meningitis, and sensorineural damage. (1728278)
1992
30
Congenital peripheral vestibular disease attributed to lymphocytic labyrinthitis in two related litters of Doberman pinscher pups. (2010340)
1991
31
Localization of substance P, CGRP, VIP, neuropeptide Y, and somatostatin immunoreactive nerve fibers in the carotid labyrinths of some amphibian species. (1717415)
1991
32
Guinea pig model of transplacental congenital cytomegaloviral infection with analysis for labyrinthitis. (1647141)
1991
33
Congenital cytomegalovirus labyrinthitis and sensorineural hearing loss in guinea pigs. (2555420)
1989
34
Ganciclovir prophylaxis for cochlear pathophysiology during experimental guinea pig cytomegalovirus labyrinthitis. (2843084)
1988
35
Pathogenesis of labyrinthitis associated with Haemophilus influenzae type b meningitis in infant rats. (3510260)
1986
36
Pathology of congenital syphilitic labyrinthitis. (7446834)
1980
37
Radiologic diagnosis of labyrinthitis ossificans. (109030)
1979
38
Labyrinthitis ossificans. (402099)
1977
39
Viral labyrinthitis -- an experimental study. (1124905)
1975
40
Deaf-mutism due to meningogenic labyrinthitis. (4868193)
1968
41
ALLERGY IN RELATION TO MENIERES SYNDROME, LABYRINTHITIS, AND HEADACHE. (14273049)
1965
42
Labyrinthitis. (14928027)
1952
43
Chronic Labyrinthitis; Fracture of Mastoid Process involving Facial Canal. (19991009)
1937
44
A Case of Simultaneous Bilateral Labyrinthitis. (19988900)
1932
45
Labyrinthitis as a Complication of Middle-ear Suppuration: (Abstract). (19983169)
1923
46
A Doubtful Case of Labyrinthitis. (19979819)
1917
47
Chronic Osteomyelitis of the Labyrinth Capsule (Paralabyrinthitis) in Suppurative Otitis Media. (19979399)
1916
48
Chronic Diffuse Labyrinthitis in a Man, aged 58. Horizontal Canal drained by a Strand of Silkworm Gut inserted into the Canal and Buried Extradurally. (19977161)
1913
49
Wax-plate Model of a Portion of the Labyrinth and the Inner Tympanic Wall in a Case of Post-suppurative Otitis Media. (19976196)
1912
50
The Operative Surgery of Labyrinthitis, based upon an experience of thirty cases. (19973286)
1908

Genetic Variations for Labyrinthitis

About this section

Expression for genes affiliated with Labyrinthitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Labyrinthitis

Search GEO for disease gene expression data for Labyrinthitis.

Pathways for genes affiliated with Labyrinthitis

About this section
Sources:
4Cell Signaling Technology
See all sources

Pathways related to Labyrinthitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0ADRB1, NCS1, NPY, CALB1
210.9ADRB1, NCS1, CALB1

Compounds for genes affiliated with Labyrinthitis

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Labyrinthitis according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2413.6CALB1, HTR3A, NPY, CHAT, CA1, ADRB1
2dopamine44 28 11 2414.6CALB1, HTR3A, NPY, NCS1, CHAT, ADRB1
3dexamethasone44 49 28 1114.6CHAT, ADRB1, IL10, HTR3A, CALB1, MAPK14
4nitric oxide44 11 2413.5MAPK14, ADRB1, IL10, CALB1, NPY, CHAT
5retinoic acid44 2412.4CALB1, F3, NPY, MAPK14, CHAT, ADRB1
6risperidone28 44 49 59 11 2416.4ADRB1, HTR3A, CHAT, IL10
7cycloheximide4411.3F3, IL10, MAPK14, CHAT, SLC5A3
85-hydroxytryptamine4411.3CALB1, HTR3A, CHAT, NPY
9choline44 11 2413.3NPY, SLC5A3, CALB1, CHAT
10forskolin44 49 1113.3GCM1, ADRB1, CHAT, NPY
11gaba4411.3CALB1, HTR3A, NPY, CHAT
12methamphetamine44 49 1113.2CHAT, CALB1, NPY
13fluoxetine49 44 28 1114.2F3, IL10, HTR3A
14tetrodotoxin44 59 2813.1CALB1, NPY, HTR3A
154-hydroxynonenal44 2412.1MAPK14, CHAT, IL10
16ibotenic acid4411.0CHAT, NPY
17haloperidol44 28 2 49 1114.9CHAT, NPY, HTR3A
18catecholamine4410.9CHAT, NPY, ADRB1
19pindolol44 28 1112.9ADRB1, HTR3A
20nmda44 2811.8CHAT, ADRB1
21acetylcholine44 49 28 11 2414.8HTR3A, CHAT, CALB1
22kainate44 2811.6CHAT, CALB1, NPY

GO Terms for genes affiliated with Labyrinthitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Labyrinthitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:03042411.0CHAT, NCS1, HTR3A, CALB1

Biological processes related to Labyrinthitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1branching involved in labyrinthine layer morphogenesisGO:06067010.7IL10, GCM1

Products for genes affiliated with Labyrinthitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Labyrinthitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet