MCID: LBY004
MIFTS: 47

Labyrinthitis malady

Ear category

Summaries for Labyrinthitis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Labyrinthitis is an ailment of the inner ear[dead link] and a form of unilateral vestibular dysfunction.... more...

MalaCards: Labyrinthitis, also known as labyrinthitis, unspecified, is related to anorexia nervosa and panic disorder. An important gene associated with Labyrinthitis is EPB41 (erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)), and among its related pathways are Neuroscience and "Ca, cAMP and Lipid Signaling". The compounds norepinephrine and dopamine have been mentioned in the context of this disorder. Related mouse phenotypes are nervous system and growth/size.

Disease Ontology:8 A inner ear infectious disease which involves inflammation of the labyrinths.

Aliases & Classifications for Labyrinthitis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 27ICD9CM, 35MeSH, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear


Aliases & Descriptions:

labyrinthitis 8 10
labyrinthitis, unspecified 8
unspecified labyrinthitis 8
labyrinthine disorder 61
labyrinthitis nos 8


External Ids:

Disease Ontology8 DOID:1468
ICD9CM27 386.30, 386.3
MeSH35 D007762
ICD1025 H83.0

Related Diseases for Labyrinthitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Labyrinthitis family:

viral labyrinthitis

Diseases related to Labyrinthitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1anorexia nervosa29.8HTR3A, NPY
2panic disorder29.8HTR3A
3viral labyrinthitis10.5
4purulent labyrinthitis10.4
5serous labyrinthitis10.4
6toxic labyrinthitis10.3
7focal labyrinthitis10.3
8endolymphatic hydrops10.3
9suppurative otitis media10.3
10sensorineural hearing loss10.2
11mumps10.2
12unilateral hyperactive labyrinth10.1
13bilateral hypoactive labyrinth10.1
14bilateral hyperactive labyrinth10.1
15congenital cytomegalovirus10.1
16pneumococcal meningitis10.1
17unilateral hypoactive labyrinth10.1
18purulent acute otitis media10.1
19vestibular disease10.1
20headache10.1
21benign paroxysmal positional nystagmus10.0
22schizophrenia10.0CHAT, NCS1, CALB1, NPAS3, HTR3A, NPY
23myocardial infarction10.0F3, HTR3A, NPY, ADRB1, MAPK14
24malignant glioma10.0ADRB1, CHAT, HTR3A, NPY, MAPK14
25vascular disease10.0MAPK14, F3, IL10, CA1
26prion disease10.0NPY, CHAT, CALB1, F3
27coronary artery disease,10.0ADRB1, HTR3A, F3, MAPK14
28parkinson's disease10.0MAPK14, CHAT, HTR3A, CALB1
29cadasil10.0ADRB1, F3, CHAT, HTR3A
30dementia10.0MAPK14, HTR3A, CHAT
31neuroepithelioma10.0CHAT, NPY, ADRB1
32acute myocardial infarction10.0F3, HTR3A, ADRB1
33septic shock10.0F3, IL10, MAPK14
34ischemia10.0CHAT, MAPK14
35respiratory failure10.0F3, NPY
36down syndrome10.0SLC5A3, CHAT
37bipolar disorder10.0HTR3A, CALB1
38cholera10.0HTR3A, CHAT
39huntington's disease10.0CHAT, NPY, CALB1
40hypertension10.0ADRB1, NPY
41fibromyalgia10.0NPY, HTR3A
42multiple system atrophy10.0CHAT
43amnestic disorder10.0HTR3A, CHAT
44hyperglycemia10.0NPY
45myasthenia gravis10.0IL10
46chagas disease10.0ADRB1
47skin cancer10.0MAPK14
48sudden infant death syndrome10.0CHAT, HTR3A
49congenital heart defect10.0ADRB1, F3, IL10
50constipation10.0HTR3A

Graphical network of the top 20 diseases related to Labyrinthitis:



Diseases related to labyrinthitis

Clinical Features for Labyrinthitis

Drugs & Therapeutics for Labyrinthitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Labyrinthitis

Drug clinical trials:

Search ClinicalTrials for Labyrinthitis

Search NIH Clinical Center for Labyrinthitis

Search CenterWatch for Labyrinthitis

Genetic Tests for Labyrinthitis

Anatomical Context for Labyrinthitis

Animal Models for Labyrinthitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Labyrinthitis

Sources:
51PubMed
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Articles related to Labyrinthitis:

(show top 50)    (show all 182)
idTitleAuthorsYear
1
Labyrinthitis ossificans. (19300296)
2009
2
Labyrinthitis ossificans: how accurate is MRI in predicting cochlear obstruction? (19393413)
2009
3
Labyrinthitis related to Wegener granulomatosis: magnetic resonance imaging findings. (18097336)
2008
4
Meningitis resulting in hearing loss and labyrinthitis ossificans - does the causative organism matter? (18246540)
2008
5
Radiology quiz case 1. Labyrinthitis ossificans (LO)-stage of fibrosis. (17372090)
2007
6
Otitis interna (labyrinthitis) associated with Salmonella enterica arizonae in turkey poults. (16617998)
2006
7
TNFalpha blockers do not improve the hearing recovery obtained with glucocorticoid therapy in an autoimmune experimental labyrinthitis. (16547758)
2006
8
Fine structure histopathology of labyrinthitis ossificans in the gerbil model. (15757198)
2005
9
Computed tomography findings of labyrinthitis ossificans secondary to meningitis: a case report. (16340290)
2005
10
Labyrinthitis ossificans associated with sensorineural deafness. (15742763)
2005
11
Horizontal vestibulo-ocular reflex dynamics in acute vestibular neuritis and viral labyrinthitis: evidence of otolith-canal interaction. (14977076)
2004
12
Case report: explantation of a cochlear implant secondary to chronic granulating labyrinthitis. (18792151)
2003
13
Preventing labyrinthitis ossificans: the role of steroids. (11177035)
2001
14
Labyrinthitis ossificans. (11605566)
2001
15
Hemorrhagic labyrinthitis. (10697929)
2000
16
Chronology of labyrinthitis ossificans induced by Streptococcus pneumoniae meningitis. (10369285)
1999
17
Induction of labyrinthitis ossificans after pneumococcal meningitis: an animal model. (9450823)
1998
18
Successful revision of failed cochlear implants in severe labyrinthitis ossificans. (8694135)
1996
19
Acute labyrinthitis associated with systemic Candida albicans infection in ageing mice. (8745774)
1996
20
Comparative perilymph permeability of cephalosporins and its significance in the treatment and prevention of suppurative labyrinthitis. (8546425)
1996
21
MR imaging of intralabyrinthine schwannoma, labyrinthitis, and other labyrinthine pathology. (7675462)
1995
22
Segmental enhancement of the cochlea on contrast-enhanced MR: correlation with the frequency of hearing loss and possible sign of perilymphatic fistula and autoimmune labyrinthitis. (8352175)
1993
23
Labyrinthitis ossificans: histopathologic consideration for cochlear implantation. (1902932)
1991
24
Guinea pig model of transplacental congenital cytomegaloviral infection with analysis for labyrinthitis. (1647141)
1991
25
Experimental Sendai virus-induced labyrinthitis in guinea pigs. An ultrastructural study of cochlear lesions. (6329059)
1984
26
Late posttraumatic rhinogenic meningitis. Temporal bone findings of meningogenic labyrinthitis. (6624592)
1983
27
Cytomegalovirus labyrinthitis in an infant: morphological, virological, and immunofluorescent studies. (6259297)
1981
28
Pathology of congenital syphilitic labyrinthitis. (7446834)
1980
29
Labyrinthitis ossificans. (402099)
1977
30
Viral labyrinthitis and transient phrenic nerve paralysis. (4144300)
1973
31
Roentgenographic changes in healed meningococcal labyrinthitis. (5502430)
1970
32
Circumscribed labyrinthitis. (6022197)
1967
33
The pathology of suppurative labyrinthitis. (4963157)
1967
34
Viral labyrinthitis--histopathologic characteristics. (6032377)
1967
35
Labyrinthitis in relation to present-day otology. (5920704)
1966
36
ALLERGY IN RELATION TO MENIERES SYNDROME, LABYRINTHITIS, AND HEADACHE. (14273049)
1965
37
STUDIES ON EXPERIMENTAL ALLERGIC (ISOIMMUNE) LABYRINTHITIS IN GUINEA PIGS. (14194820)
1964
38
Bilateral subactue otitis media, with labyrinthitis and total loss of usable hearing: resistance to antibiotics. (14445640)
1960
39
Evaluation of vertigo; differential diagnosis of Meniere's disease, acute labyrinthitis, tumors of the cerebellopontine angle and insufficiency of the basilar artery. (13614054)
1958
40
Past and present treatment of labyrinthitis otogenes. (13487006)
1958
41
A case of mumps labyrinthitis. (13491930)
1957
42
Fistular labyrinthitis; follow-up on 95 operated patients. (13275308)
1955
43
Suppurative labyrinthitis. (14911873)
1952
44
Chronic Labyrinthitis. (19991445)
1938
45
Bilateral Chronic Suppurative Otitis Media. Acute Serous Labyrinthitis of Right Ear. Radical Mastoid Operation in Quiescent Stage. Modified Radical Operation Left Ear. (19991398)
1938
46
Chronic Labyrinthitis; Fracture of Mastoid Process involving Facial Canal. (19991009)
1937
47
Labyrinthitis as a Complication of Middle-ear Suppuration: (Abstract). (19983169)
1923
48
A Case of Chronic Middle Ear Suppurations, Cholesteatoma, and Mastoiditis, complicated by Labyrinthitis, Sinus, Thrombosis and Meningitis. (20312229)
1920
49
Labyrinthitis; Diffuse Purulent Meningitis; Labyrinthectomy; Cure. (19981252)
1920
50
Meningitic Neuro-labyrinthitis. (19981241)
1920

Genetic Variations for Labyrinthitis

Expression for genes affiliated with Labyrinthitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Labyrinthitis

Search GEO for disease gene expression data for Labyrinthitis.

Pathways for genes affiliated with Labyrinthitis

Sources:
4Cell Signaling Technology
See all sources

Pathways related to Labyrinthitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0ADRB1, NCS1, NPY, CALB1
210.9ADRB1, NCS1, CALB1

Compounds for genes affiliated with Labyrinthitis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Labyrinthitis according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1norepinephrine45 11 2413.6CA1, CALB1, HTR3A, NPY, CHAT, ADRB1
2dopamine45 29 11 2414.6CALB1, HTR3A, NPY, NCS1, CHAT, ADRB1
3dexamethasone45 50 29 1114.6CALB1, HTR3A, CHAT, MAPK14, IL10, ADRB1
4nitric oxide45 11 2413.5CALB1, NPY, CHAT, MAPK14, IL10, ADRB1
5retinoic acid45 2412.4CALB1, NPY, CHAT, MAPK14, F3, ADRB1
6risperidone29 45 50 60 11 2416.4ADRB1, IL10, CHAT, HTR3A
7cycloheximide4511.3SLC5A3, F3, IL10, MAPK14, CHAT
85-hydroxytryptamine4511.3CHAT, NPY, HTR3A, CALB1
9choline45 11 2413.3CALB1, NPY, CHAT, SLC5A3
10forskolin45 50 1113.3ADRB1, CHAT, NPY, GCM1
11gaba4511.3CALB1, HTR3A, NPY, CHAT
12methamphetamine45 50 1113.2CALB1, NPY, CHAT
13fluoxetine50 45 29 1114.2HTR3A, IL10, F3
14tetrodotoxin45 60 2913.1CALB1, HTR3A, NPY
154-hydroxynonenal45 2412.1CHAT, MAPK14, IL10
16ibotenic acid4511.0CHAT, NPY
17haloperidol45 29 2 50 1114.9HTR3A, NPY, CHAT
18kainate45 2911.9CALB1, NPY, CHAT
19pindolol45 29 1112.9ADRB1, HTR3A
20nmda45 2911.8ADRB1, CHAT
21acetylcholine45 50 29 11 2414.8CHAT, HTR3A, CALB1
22catecholamine4510.6CHAT, ADRB1, NPY

GO Terms for genes affiliated with Labyrinthitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Labyrinthitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:03042411.0CHAT, NCS1, HTR3A, CALB1

Biological processes related to Labyrinthitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1branching involved in labyrinthine layer morphogenesisGO:06067010.7IL10, GCM1

Products for genes affiliated with Labyrinthitis

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  • Lysates
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Sources for Labyrinthitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet