Labyrinthitis malady

Wikipedia: Labyrinthitis is an ailment of the inner ear and a form of unilateral vestibular dysfunction. It derives...⁴⁴ more...

MalaCards: Labyrinthitis, also known as unspecified labyrinthitis (disorder), is related to transient global amnesia and amnestic disorder. An important gene associated with Labyrinthitis is EPB41 (erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)), and among its related pathways is Sympathetic Nerve Pathway (Neuroeffector Junction). The compounds ibotenic acid and pindolol have been mentioned in the context of this disorder. Affiliated tissues include endothelial, and related mouse phenotypes are muscle and nervous system.

Disease Ontology: A inner ear infectious disease which involves inflammation of the labyrinths.⁶

Aliases & Descriptions:

labyrinthitis 6 8 43 unspecified labyrinthitis (disorder) 6 labyrinthitis nos (disorder) 6

labyrinthitis, unspecified 6 labyrinthitis (disorder) 6

Diseases related to labyrinthitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 88)

id	Related Disease	Score	Top Affiliating Genes
1	transient global amnesia	13.3	CA1, CRLF1
2	amnestic disorder	13.1	CHAT, HTR3A
3	generalized anxiety disorder	12.9	NPY, HTR3A
4	subependymal giant cell astrocytoma	12.9	NPY, CALB1
5	social phobia	12.9	HTR3A, NPY
6	neuroepithelioma	12.8	CHAT, NPY, ADRB1
7	supranuclear palsy	12.7	CHAT, NPY, HTR3A
8	huntington's disease	12.7	NPY, CALB1, CHAT
9	constipation	12.6	NPY, HTR3A, CHAT
10	febrile seizures	12.5	IL10, NPY, CALB1
11	sudden infant death syndrome	12.4	HTR3A, CHAT, IL10
12	fibromyalgia	12.4	IL10, HTR3A, NPY
13	hydrocephalus	12.3	NPY, CRLF1, IL10
14	albinism	12.3	F3, CHAT, NPY, CALB1
15	anorexia nervosa	12.3	NCS1, ADRB1, HTR3A, NPY
16	cadasil	12.3	HTR3A, F3, CHAT, ADRB1
17	acquired immunodeficiency syndrome	12.2	CALB1, F3, IL10
18	multiple system atrophy	12.2	CHAT, IL10, CALB1, NPY
19	hemolytic anemia	12.2	IL10, EPB41, F3
20	chronic fatigue syndrome	12.2	NPY, IL10, HTR3A, ADRB1
21	sleep apnea	12.1	ADRB1, NPY, IL10, HTR3A
22	myasthenia gravis	12.1	CHAT, F3, IL10, ADRB1
23	prion disease	12.1	HTR3A, F3, CHAT, NPY
24	panic disorder	12.1	IL10, HTR3A, NPY
25	congenital myasthenic syndrome	12.1	F3, IL10, ADRB1, CHAT
26	ischemic heart disease	12.1	ADRB1, HTR3A, MAPK14
27	vaginitis	12.1	NPY, IL10, HOXA13, F3
28	congestive heart failure	12.0	NPY, ADRB1, F3, IL10
29	respiratory failure	12.0	CHAT, IL10, F3, NPY
30	diabetic retinopathy	12.0	NPY, CA1, F3, IL10
31	brain injury	12.0	CALB1, HTR3A, IL10, F3
32	septic shock	11.9	IL10, MAPK14, F3
33	coronary artery anomaly	11.9	MAPK14, F3, ADRB1, HTR3A
34	apnea	11.8	NPY, IL10, CHAT, ADRB1, HTR3A
35	chagas disease	11.8	ADRB1, CHAT, MAPK14, IL10
36	aldosteronism	11.8	MAPK14, HTR3A, NPY, ADRB1
37	congenital heart defect	11.7	MAPK14, F3, HAND1, IL10
38	atrial fibrillation	11.7	ADRB1, NPY, IL10, HTR3A, F3
39	acute myocardial infarction	11.6	HTR3A, ADRB1, NPY, F3, IL10
40	encephalitis	11.6	F3, CALB1, MAPK14, IL10
41	stomach carcinoma	11.5	F3, HTR3A, MAPK14, IL10
42	bipolar disorder	11.5	CALB1, NPAS3, NPY, CHAT, HTR3A, NCS1
43	pre-eclampsia	11.5	GCM1, IL10, MAPK14, F3
44	skin cancer	11.5	HTR3A, F3, MAPK14, IL10
45	eclampsia	11.5	IL10, MAPK14, GCM1, F3
46	dengue hemorrhagic fever	11.5	F3, MAPK14, IL10
47	malignant glioma	11.5	ADRB1, MAPK14, NPY, HTR3A, CHAT
48	cholera	11.4	IL10, MAPK14, HTR3A, CALB1, CHAT
49	severe acute respiratory syndrome	11.4	F3, IL10, MAPK14
50	duodenitis	11.3	IL10, MAPK14, HTR3A, CALB1, NPY

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to labyrinthitis:

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MGI Mouse Phenotypes related to labyrinthitis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle phenotype	MP:0005369	7.6	ADRB1, F3, MAPK14, IL10, CHAT, HAND1
2	nervous system phenotype	MP:0003631	7.3	GCM1, HAND1, NPY, NPAS3, CRLF1, CALB1
3	normal phenotype	MP:0002873	7.2	HAND1, NPY, F3, MAPK14, IL10, CHAT
4	behavior/neurological phenotype	MP:0005386	6.7	NPY, NPAS3, CRLF1, CALB1, HTR3A, F3
5	mortality/aging	MP:0010768	5.9	CRLF1, NPAS3, ADRB1, HAND1, HOXA13, HTR3A
6	growth/size phenotype	MP:0005378	5.9	HAND1, ADRB1, NPY, NPAS3, HOXA13, HTR3A
7	homeostasis/metabolism phenotype	MP:0005376	5.8	NPY, ADRB1, HAND1, EPB41, NPAS3, HOXA13

Articles related to labyrinthitis:

(show all 11)

id	Title	Authors	Year	Affiliating Genes
1	Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth. (18448564)	Simmons D.G.... Cross J.C.	2008	HAND1, GCM1
2	Schizopsychotic symptom-profiles and biomarkers: beac ons in diagnostic labyrinths. (19073416)	Palomo T.... Archer T.	2008	NPAS3
3	HOXA13 Is essential for placental vascular patterning and labyrinth endothelial specification. (18483557)	Shaut C.A.... Stadler H.S.	2008	HOXA13
4	Interleukin-10 in viral diseases and cancer: exiting the labyrinth? (15546396)	Vicari A.P.... Trinchieri G.	2004	IL10
5	Localization of beta1-adrenergic receptors in the cochlea and the vestibular labyrinth. (15635809)	Fauser C.... Wangemann P.	2004	ADRB1
6	Decreased expression of calretinin and calbindin in the labyrinth of old gerbils. (12445979)	Kevetter G.A.... Leonard R.B.	2002	CALB1
7	Neurotransmission in the human labyrinth. (11885650)	Schrott-Fischer A.... Eybalin M.	2002	CHAT
8	Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation. (10393961)	Erlich J.... Mackman N.	1999	F3
9	Peptidergic innervation in the amphibian carotid labyrinth. (7756737)	Kusakabe T.... Takenaka T.	1995	NPY
10	Immunocytochemistry of carbonic anhydrase and non-rad ioactive detection of its RNA by in situ hydridization in the chick embryo memb ranous labyrinth. (7530513)	Balsamo G.... Marmo F.	1994	CA1
11	Noci-autonomic-affective automatism, the physiopathological essence of hemicrania. The serotonin theory as a guiding principle in the labyrinth of interpretations (1297400)	Nicolodi M.... Sicuteri R.	1992	HTR3A

Genes related to labyrinthitis according to GeneCards:

(show all 16)

id	Symbol	Description	Score	GeneCards Section Context
1	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	11.0
2	HAND1	heart and neural crest derivatives expressed 1	11.0	Publications
3	HOXA13	homeobox A13	11.0	Publications
4	GCM1	glial cells missing homolog 1 (Drosophila)	11.0	Publications
5	CRLF1	cytokine receptor-like factor 1	11.0
6	CA1	carbonic anhydrase I	11.0	Publications
7	ADRB1	adrenoceptor beta 1	11.0	Publications
8	CALB1	calbindin 1, 28kDa	11.0	Publications
9	CHAT	choline O-acetyltransferase	11.0	Publications
10	NCS1	neuronal calcium sensor 1	11.0
11	NPY	neuropeptide Y	11.0	Publications
12	HTR3A	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	11.0	Publications
13	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
14	IL10	interleukin 10	11.0	Publications
15	MAPK14	mitogen-activated protein kinase 14	11.0	Functions
16	NPAS3	neuronal PAS domain protein 3	11.0	Publications

Pathways related to labyrinthitis according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Sympathetic Nerve Pathway (Neuroeffector Junction)34	9.4	CHAT, NPY, ADRB1

Compounds related to labyrinthitis according to GeneDecks:

(show all 21)

id	Compound	Score	Top Affiliating Genes
1	ibotenic acid32	10.0	CHAT, NPY
2	pindolol32 9 9	11.9	ADRB1, HTR3A
3	methamphetamine32 9 9	11.7	CHAT, CALB1, NPY
4	tetrodotoxin32	9.5	NPY, CALB1, HTR3A
5	haloperidol32 34 9 9	12.4	CHAT, HTR3A, NPY
6	catecholamine32	9.3	ADRB1, NPY, CHAT
7	5-hydroxytryptamine32	9.3	NPY, CALB1, HTR3A, CHAT
8	fluoxetine32 34 9 9	12.2	HTR3A, F3, IL10
9	gaba32 42	10.2	NPY, CALB1, HTR3A, CHAT
10	nmda32 42	10.2	ADRB1, NPY, CALB1, CHAT
11	forskolin32 42 9 9	12.1	GCM1, CHAT, CALB1, NPY, ADRB1
12	potassium32 9 18 9	12.1	NCS1, CHAT, CALB1, ADRB1
13	kainate32	9.1	NPY, CALB1, CHAT
14	risperidone32 34 9 18 9	13.1	CHAT, IL10, HTR3A, ADRB1
15	acetylcholine32 9 18 9	11.9	NPY, CALB1, HTR3A, CHAT
16	4-hydroxynonenal32 18	9.9	CHAT, IL10, MAPK14
17	norepinephrine32 9 18 9	11.7	ADRB1, NPY, CA1, CALB1, HTR3A, CHAT
18	dopamine32 9 18 9	11.6	ADRB1, NPY, CALB1, HTR3A, CHAT, NCS1
19	retinoic acid32 42 18	10.0	ADRB1, NPY, CALB1, F3, MAPK14, CHAT
20	nitric oxide32 9 18 9	10.9	ADRB1, NPY, CALB1, MAPK14, IL10, CHAT
21	dexamethasone32 42 34 9 9	11.9	ADRB1, CALB1, HTR3A, MAPK14, IL10, CHAT

Cellular components related to labyrinthitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	axon	GO:030424	8.7	NCS1, CHAT, HTR3A, CALB1
2	cytoplasm	GO:005737	6.4	ADRB1, NPAS3, CRLF1, CA1, HTR3A, F3

Biological processes related to labyrinthitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	branching involved in labyrinthine layer morphogenesis	GO:060670	9.6	GCM1, IL10