MCID: LCR001
MIFTS: 34

Lacrimal Duct Obstruction

Categories: Eye diseases

Aliases & Classifications for Lacrimal Duct Obstruction

MalaCards integrated aliases for Lacrimal Duct Obstruction:

Name: Lacrimal Duct Obstruction 12 41 14
Obstruction of Lacrimal Canaliculus 12
Obstruction of Lacrimal Ducts 12
Blocked Lacrimal Canaliculus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13929
MeSH 41 D007767
NCIt 46 C34757
UMLS 69 C0022906

Summaries for Lacrimal Duct Obstruction

MalaCards based summary : Lacrimal Duct Obstruction, also known as obstruction of lacrimal canaliculus, is related to branchiooculofacial syndrome and dacryocystitis. An important gene associated with Lacrimal Duct Obstruction is DCXR (Dicarbonyl And L-Xylulose Reductase), and among its related pathways/superpathways is Hypothetical Craniofacial Development Pathway. The drugs Ephedrine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are behavior/neurological and craniofacial

Related Diseases for Lacrimal Duct Obstruction

Graphical network of the top 20 diseases related to Lacrimal Duct Obstruction:



Diseases related to Lacrimal Duct Obstruction

Symptoms & Phenotypes for Lacrimal Duct Obstruction

MGI Mouse Phenotypes related to Lacrimal Duct Obstruction:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 EYA1 HOXC13 MBD5 PGRMC1 SIX1 TFAP2A
2 craniofacial MP:0005382 9.95 EYA1 HOXC13 MBD5 SIX1 TFAP2A TGFB1
3 endocrine/exocrine gland MP:0005379 9.87 EYA1 MBD5 SIX1 SIX5 TFAP2A TGFB1
4 digestive/alimentary MP:0005381 9.85 TP63 EYA1 HOXC13 SIX1 TFAP2A TGFB1
5 skeleton MP:0005390 9.7 EYA1 HOXC13 MBD5 SIX1 TFAP2A TGFB1
6 limbs/digits/tail MP:0005371 9.65 SIX1 TFAP2A TP63 HOXC13 MBD5
7 vision/eye MP:0005391 9.17 EYA1 HOXC13 SIX1 SIX5 TFAP2A TGFB1
8 taste/olfaction MP:0005394 9.13 PGRMC1 SIX1 TP63

Drugs & Therapeutics for Lacrimal Duct Obstruction

Drugs for Lacrimal Duct Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ephedrine Approved Phase 1, Phase 2 299-42-3 9294
2
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
3
Pseudoephedrine Approved Phase 1, Phase 2 90-82-4 7028
4
Tetracaine Approved, Vet_approved Phase 1, Phase 2 94-24-6 5411
5 Anesthetics Phase 1, Phase 2
6 Ether
7 Mitomycins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Comparative Study of Two Endoscopic Operations for Lacrimal Duct Obstruction Completed NCT02636257 Phase 1, Phase 2
2 Analysis of 86 Dacryoliths at the University Hospital Ostrava Completed NCT01826734
3 Risk and Importance of Peroperative Nasal Hemorrhage in the Treatment of Lacrimal Duct Obstruction in Young Children Recruiting NCT02851641
4 Endoscopic Dacryocystorhinostomy Prospective Research Active, not recruiting NCT00571129
5 A Feasibility Study to Develop a Protocol for Functional Lacrimal Magnetic Resonance Imaging Not yet recruiting NCT03411889

Search NIH Clinical Center for Lacrimal Duct Obstruction

Cochrane evidence based reviews: lacrimal duct obstruction

Genetic Tests for Lacrimal Duct Obstruction

Anatomical Context for Lacrimal Duct Obstruction

MalaCards organs/tissues related to Lacrimal Duct Obstruction:

38
Eye

Publications for Lacrimal Duct Obstruction

Articles related to Lacrimal Duct Obstruction:

(show all 16)
# Title Authors Year
1
Intervention using a novel biodegradable hollow stent containing polylactic acid-polyprolactone-polyethylene glycol complexes against lacrimal duct obstruction disease. ( 28570687 )
2017
2
An insertion mutation in HOXC13 underlies pure hair and nail ectodermal dysplasia with lacrimal duct obstruction. ( 29278420 )
2017
3
Cytokine Profiles of Tear Fluid From Patients With Pediatric Lacrimal Duct Obstruction. ( 28114586 )
2017
4
Factors Associated with the Efficacy of Probing for Adult Patients with Lacrimal Duct Obstruction. ( 27015237 )
2016
5
Relationship between frequent swimming pool use and lacrimal duct obstruction. ( 24112783 )
2013
6
Direct endoscopic probing for congenital lacrimal duct obstruction. ( 23566023 )
2013
7
Transcanalicular approach to adult lacrimal duct obstruction: a review of instruments and methods. ( 19320304 )
2009
8
Uncommon presentation of congenital lacrimal duct obstruction a case report of congenital amniontocele. ( 22400096 )
2007
9
Eosinophilic angiocentric fibrosis: an unusual entity producing complete lacrimal duct obstruction. ( 16754230 )
2006
10
The clinical value of dacryoscintigraphy in the selection of surgical approach for patients with functional lacrimal duct obstruction. ( 16248384 )
2005
11
Diagnostic Ophthalmology. Left dacryocystitis with naso-lacrimal duct obstruction. ( 15600163 )
2004
12
Dilatation and stenting for naso-lacrimal duct obstruction: a pilot project. ( 10551300 )
1999
13
Bacteriology of lacrimal duct obstruction in adults. ( 9135406 )
1997
14
Silicone intubation for the treatment of congenital lacrimal duct obstruction: successful results removing the tubes after six weeks. ( 3211482 )
1988
15
CORTICOSTEROIDS AND FIBROLYSIN IN THE PREVENTION OF LACRIMAL DUCT OBSTRUCTION. ( 18170750 )
1962
16
The management of lacrimal duct obstruction. ( 14824621 )
1951

Variations for Lacrimal Duct Obstruction

Expression for Lacrimal Duct Obstruction

Search GEO for disease gene expression data for Lacrimal Duct Obstruction.

Pathways for Lacrimal Duct Obstruction

Pathways related to Lacrimal Duct Obstruction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.53 TFAP2A TP63

GO Terms for Lacrimal Duct Obstruction

Cellular components related to Lacrimal Duct Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.32 DCXR EYA1 HOXC13 MBD5 OPTN SIX1

Biological processes related to Lacrimal Duct Obstruction according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 9.92 HOXC13 SIX1 TFAP2A TP63
2 negative regulation of transcription, DNA-templated GO:0045892 9.88 SIX5 TFAP2A TGFB1 TP63
3 positive regulation of transcription, DNA-templated GO:0045893 9.8 EYA1 SIX1 TFAP2A TGFB1 TP63
4 sensory perception of sound GO:0007605 9.71 EYA1 SIX1 TFAP2A
5 branching involved in ureteric bud morphogenesis GO:0001658 9.62 EYA1 SIX1
6 hair follicle development GO:0001942 9.61 HOXC13 TP63
7 positive regulation of Notch signaling pathway GO:0045747 9.6 EYA1 TP63
8 embryonic cranial skeleton morphogenesis GO:0048701 9.59 SIX1 TFAP2A
9 positive regulation of bone mineralization GO:0030501 9.58 TFAP2A TGFB1
10 embryonic forelimb morphogenesis GO:0035115 9.57 TFAP2A TP63
11 regulation of neuron differentiation GO:0045664 9.56 EYA1 SIX1
12 cochlea morphogenesis GO:0090103 9.55 EYA1 SIX1
13 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.52 SIX1 TGFB1
14 middle ear morphogenesis GO:0042474 9.51 EYA1 SIX1
15 inner ear morphogenesis GO:0042472 9.5 EYA1 SIX1 TFAP2A
16 pharyngeal system development GO:0060037 9.49 EYA1 SIX1
17 neuron fate specification GO:0048665 9.48 EYA1 SIX1
18 anatomical structure development GO:0048856 9.46 EYA1 SIX1
19 aorta morphogenesis GO:0035909 9.43 EYA1 SIX1
20 pattern specification process GO:0007389 9.43 EYA1 SIX1 TP63
21 otic vesicle development GO:0071599 9.37 EYA1 SIX1
22 positive regulation of transcription by RNA polymerase II GO:0045944 9.17 EYA1 HOXC13 SIX1 SIX5 TFAP2A TGFB1
23 positive regulation of secondary heart field cardioblast proliferation GO:0072513 9.16 EYA1 SIX1
24 ureteric bud development GO:0001657 9.13 EYA1 SIX1 TGFB1
25 multicellular organism development GO:0007275 10.01 EYA1 HOXC13 SIX1 SIX5 TP63

Molecular functions related to Lacrimal Duct Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 9.46 HOXC13 SIX1 TFAP2A TP63
2 transcription regulatory region DNA binding GO:0044212 9.43 SIX1 TFAP2A TP63
3 sequence-specific DNA binding GO:0043565 9.35 HOXC13 SIX1 SIX5 TFAP2A TP63
4 chromatin binding GO:0003682 9.02 HOXC13 MBD5 SIX1 TFAP2A TP63

Sources for Lacrimal Duct Obstruction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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