MCID: LCR001
MIFTS: 27

Lacrimal Duct Obstruction malady

Summaries for Lacrimal Duct Obstruction

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32MalaCards
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MalaCards: Lacrimal Duct Obstruction, also known as obstruction of lacrimal canaliculus, is related to branchiooculofacial syndrome and dacryocystitis. An important gene associated with Lacrimal Duct Obstruction is SIX5 (SIX homeobox 5), and among its related pathways is Transcriptional misregulation in cancer. Related mouse phenotypes are endocrine/exocrine gland and muscle.

Aliases & Classifications for Lacrimal Duct Obstruction

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

lacrimal duct obstruction 8 10 60
obstruction of lacrimal canaliculus 8
obstruction of lacrimal ducts 8
blocked lacrimal canaliculus 8


External Ids:

Disease Ontology8 DOID:13929
NCIt39 C34757
MeSH34 D007767

Related Diseases for Lacrimal Duct Obstruction

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17GeneCards, 18GeneDecks
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Diseases related to Lacrimal Duct Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1branchiooculofacial syndrome10.2
2dacryocystitis10.2
3deafness, epiphyseal dysplasia, short stature10.2
4cataract10.0SIX5
5primary hyperoxaluria10.0SIX1, EYA1
6renal agenesis10.0SIX1, EYA1
7chronic kidney failure10.0SIX1, EYA1
8branchiootorenal spectrum disorders10.0EYA1, SIX5, SIX1
9branchiootorenal syndrome10.0EYA1, SIX5, SIX1

Graphical network of diseases related to Lacrimal Duct Obstruction:



Diseases related to lacrimal duct obstruction

Clinical Features for Lacrimal Duct Obstruction

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Drugs & Therapeutics for Lacrimal Duct Obstruction

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Genetic Tests for Lacrimal Duct Obstruction

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Anatomical Context for Lacrimal Duct Obstruction

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Animal Models for Lacrimal Duct Obstruction or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lacrimal Duct Obstruction:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.8SIX1, SIX5, EYA1
2MP:00053698.7SIX1, SIX5, EYA1
3MP:00053918.5SIX1, SIX5, EYA1

Publications for Lacrimal Duct Obstruction

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50PubMed
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Articles related to Lacrimal Duct Obstruction:

(show all 13)
idTitleAuthorsYear
1
Relationship between frequent swimming pool use and lacrimal duct obstruction. (24112783)
2013
2
Direct endoscopic probing for congenital lacrimal duct obstruction. (23566023)
2013
3
Effectiveness of primary monocanalicularnasal intubation with Monoka tubes and nasal endoscopic findings for congenital nasolacrimal duct obstruction with enlarged lacrimal sac and chronic dacryocystitis. (23147293)
2012
4
Transcanalicular approach to adult lacrimal duct obstruction: a review of instruments and methods. (19320304)
2009
5
Uncommon presentation of congenital lacrimal duct obstruction a case report of congenital amniontocele. (22400096)
2007
6
Eosinophilic angiocentric fibrosis: an unusual entity producing complete lacrimal duct obstruction. (16754230)
2006
7
The clinical value of dacryoscintigraphy in the selection of surgical approach for patients with functional lacrimal duct obstruction. (16248384)
2005
8
Diagnostic Ophthalmology. Left dacryocystitis with naso-lacrimal duct obstruction. (15600163)
2004
9
Dilatation and stenting for naso-lacrimal duct obstruction: a pilot project. (10551300)
1999
10
Bacteriology of lacrimal duct obstruction in adults. (9135406)
1997
11
Silicone intubation for the treatment of congenital lacrimal duct obstruction: successful results removing the tubes after six weeks. (3211482)
1988
12
CORTICOSTEROIDS AND FIBROLYSIN IN THE PREVENTION OF LACRIMAL DUCT OBSTRUCTION. (18170750)
1962
13
The management of lacrimal duct obstruction. (14824621)
1951

Genetic Variations for Lacrimal Duct Obstruction

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Expression for genes affiliated with Lacrimal Duct Obstruction

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lacrimal Duct Obstruction

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Pathways for genes affiliated with Lacrimal Duct Obstruction

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29KEGG
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Pathways related to Lacrimal Duct Obstruction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3SIX1, EYA1

Compounds for genes affiliated with Lacrimal Duct Obstruction

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GO Terms for genes affiliated with Lacrimal Duct Obstruction

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16Gene Ontology
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Biological processes related to Lacrimal Duct Obstruction according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of secondary heart field cardioblast proliferationGO:0725139.6SIX1, EYA1
2aorta morphogenesisGO:0359099.6SIX1, EYA1
3neuron fate specificationGO:0486659.6SIX1, EYA1
4pharyngeal system developmentGO:0600379.6EYA1, SIX1
5regulation of neuron differentiationGO:0456649.5EYA1, SIX1
6cochlea morphogenesisGO:0901039.5EYA1, SIX1
7middle ear morphogenesisGO:0424749.5EYA1, SIX1
8outflow tract morphogenesisGO:0031519.4SIX1, EYA1
9embryonic skeletal system morphogenesisGO:0487049.4SIX1, EYA1
10branching involved in ureteric bud morphogenesisGO:0016589.3EYA1, SIX1
11pattern specification processGO:0073899.2SIX1, EYA1
12sensory perception of soundGO:0076059.0SIX1, EYA1
13transcription, DNA-dependentGO:0063518.8SIX1, SIX5, EYA1

Products for genes affiliated with Lacrimal Duct Obstruction

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Sources for Lacrimal Duct Obstruction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet