MCID: LCR001
MIFTS: 29

Lacrimal Duct Obstruction malady

Eye diseases category

Summaries for Lacrimal Duct Obstruction

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34MalaCards
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MalaCards: Lacrimal Duct Obstruction, also known as obstruction of lacrimal canaliculus, is related to branchiooculofacial syndrome and dacryocystitis. An important gene associated with Lacrimal Duct Obstruction is DCXR (dicarbonyl/L-xylulose reductase), and among its related pathways is Transcriptional misregulation in cancer. Affiliated tissues include eye, and related mouse phenotypes are endocrine/exocrine gland and vision/eye.

Aliases & Classifications for Lacrimal Duct Obstruction

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9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

lacrimal duct obstruction 9 11 63
obstruction of lacrimal canaliculus 9
obstruction of lacrimal ducts 9
blocked lacrimal canaliculus 9


External Ids:

Disease Ontology9 DOID:13929
NCIt41 C34757
MeSH36 D007767

Related Diseases for Lacrimal Duct Obstruction

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18GeneCards, 19GeneDecks
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Diseases related to Lacrimal Duct Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1branchiooculofacial syndrome10.2
2dacryocystitis10.2
3deafness, epiphyseal dysplasia, short stature10.2
4brachiootic syndrome 310.0SIX1
5chronic kidney failure10.0SIX1, EYA1
6primary hyperoxaluria10.0SIX1, EYA1
7renal agenesis9.9SIX1, EYA1
8branchiootorenal spectrum disorders9.9EYA1, SIX1, SIX5
9branchiootorenal syndrome9.9EYA1, SIX1, SIX5

Graphical network of diseases related to Lacrimal Duct Obstruction:



Diseases related to lacrimal duct obstruction

Symptoms for Lacrimal Duct Obstruction

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Drugs & Therapeutics for Lacrimal Duct Obstruction

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Lacrimal Duct Obstruction

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Anatomical Context for Lacrimal Duct Obstruction

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34MalaCards
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MalaCards organs/tissues related to Lacrimal Duct Obstruction:

34
Eye

Animal Models for Lacrimal Duct Obstruction or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Lacrimal Duct Obstruction:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.5SIX5, SIX1, EYA1
2MP:00053918.4SIX5, SIX1, EYA1
3MP:00053698.2SIX5, SIX1, EYA1

Publications for Lacrimal Duct Obstruction

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53PubMed
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Articles related to Lacrimal Duct Obstruction:

(show all 12)
idTitleAuthorsYear
1
Relationship between frequent swimming pool use and lacrimal duct obstruction. (24112783)
2013
2
Direct endoscopic probing for congenital lacrimal duct obstruction. (23566023)
2013
3
Transcanalicular approach to adult lacrimal duct obstruction: a review of instruments and methods. (19320304)
2009
4
Uncommon presentation of congenital lacrimal duct obstruction a case report of congenital amniontocele. (22400096)
2007
5
Eosinophilic angiocentric fibrosis: an unusual entity producing complete lacrimal duct obstruction. (16754230)
2006
6
The clinical value of dacryoscintigraphy in the selection of surgical approach for patients with functional lacrimal duct obstruction. (16248384)
2005
7
Diagnostic Ophthalmology. Left dacryocystitis with naso-lacrimal duct obstruction. (15600163)
2004
8
Dilatation and stenting for naso-lacrimal duct obstruction: a pilot project. (10551300)
1999
9
Bacteriology of lacrimal duct obstruction in adults. (9135406)
1997
10
Silicone intubation for the treatment of congenital lacrimal duct obstruction: successful results removing the tubes after six weeks. (3211482)
1988
11
CORTICOSTEROIDS AND FIBROLYSIN IN THE PREVENTION OF LACRIMAL DUCT OBSTRUCTION. (18170750)
1962
12
The management of lacrimal duct obstruction. (14824621)
1951

Variations for Lacrimal Duct Obstruction

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Expression for genes affiliated with Lacrimal Duct Obstruction

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lacrimal Duct Obstruction

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Pathways for genes affiliated with Lacrimal Duct Obstruction

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51PathCards, 31KEGG
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Pathways related to Lacrimal Duct Obstruction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1SIX1, EYA1

Compounds for genes affiliated with Lacrimal Duct Obstruction

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GO Terms for genes affiliated with Lacrimal Duct Obstruction

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17Gene Ontology
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Biological processes related to Lacrimal Duct Obstruction according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of secondary heart field cardioblast proliferationGO:0725139.4SIX1, EYA1
2aorta morphogenesisGO:0359099.4SIX1, EYA1
3neuron fate specificationGO:0486659.4SIX1, EYA1
4pharyngeal system developmentGO:0600379.4EYA1, SIX1
5regulation of neuron differentiationGO:0456649.3SIX1, EYA1
6cochlea morphogenesisGO:0901039.3SIX1, EYA1
7middle ear morphogenesisGO:0424749.3EYA1, SIX1
8outflow tract morphogenesisGO:0031519.2SIX1, EYA1
9embryonic skeletal system morphogenesisGO:0487049.2SIX1, EYA1
10branching involved in ureteric bud morphogenesisGO:0016589.1SIX1, EYA1
11pattern specification processGO:0073899.0EYA1, SIX1
12sensory perception of soundGO:0076058.8SIX1, EYA1
13transcription, DNA-templatedGO:0063518.5SIX5, SIX1, EYA1

Molecular functions related to Lacrimal Duct Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:0435659.0SIX5, SIX1

Products for genes affiliated with Lacrimal Duct Obstruction

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Lacrimal Duct Obstruction

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet