MCID: LCR001
MIFTS: 23

Lacrimal Duct Obstruction malady

Summaries for Lacrimal Duct Obstruction

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MalaCards based summary: Lacrimal Duct Obstruction, also known as obstruction of lacrimal canaliculus, is related to branchiooculofacial syndrome and dacryocystitis. An important gene associated with Lacrimal Duct Obstruction is DCXR (dicarbonyl/L-xylulose reductase), and among its related pathways is Transcriptional misregulation in cancer. Related mouse phenotypes are endocrine/exocrine gland and vision/eye.

Aliases & Classifications for Lacrimal Duct Obstruction

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Lacrimal Duct Obstruction, Aliases & Descriptions:

Name: Lacrimal Duct Obstruction 9 11 60
Obstruction of Lacrimal Canaliculus 9
 
Obstruction of Lacrimal Ducts 9
Blocked Lacrimal Canaliculus 9


External Ids:

Disease Ontology9 DOID:13929
MeSH33 D007767
NCIt38 C34757

Related Diseases for Lacrimal Duct Obstruction

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Diseases related to Lacrimal Duct Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1branchiooculofacial syndrome10.2
2dacryocystitis10.2
3deafness, epiphyseal dysplasia, short stature10.2
4brachiootic syndrome 310.1SIX1
5chronic kidney failure9.9EYA1, SIX1
6primary hyperoxaluria9.8EYA1, SIX1
7renal hypodysplasia/aplasia 19.7EYA1, SIX1
8branchiootorenal spectrum disorders9.7SIX1, SIX5, EYA1
9branchiootorenal syndrome9.6EYA1, SIX1, SIX5

Graphical network of diseases related to Lacrimal Duct Obstruction:



Diseases related to lacrimal duct obstruction

Symptoms for Lacrimal Duct Obstruction

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Drugs & Therapeutics for Lacrimal Duct Obstruction

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Drug clinical trials:

Search ClinicalTrials for Lacrimal Duct Obstruction

Search NIH Clinical Center for Lacrimal Duct Obstruction

Genetic Tests for Lacrimal Duct Obstruction

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Anatomical Context for Lacrimal Duct Obstruction

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Animal Models for Lacrimal Duct Obstruction or affiliated genes

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MGI Mouse Phenotypes related to Lacrimal Duct Obstruction:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.5SIX5, SIX1, EYA1
2MP:00053918.4SIX5, SIX1, EYA1
3MP:00053698.2SIX5, SIX1, EYA1

Publications for Lacrimal Duct Obstruction

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Articles related to Lacrimal Duct Obstruction:

(show all 12)
idTitleAuthorsYear
1
Relationship between frequent swimming pool use and lacrimal duct obstruction. (24112783)
2013
2
Direct endoscopic probing for congenital lacrimal duct obstruction. (23566023)
2013
3
Transcanalicular approach to adult lacrimal duct obstruction: a review of instruments and methods. (19320304)
2009
4
Uncommon presentation of congenital lacrimal duct obstruction a case report of congenital amniontocele. (22400096)
2007
5
Eosinophilic angiocentric fibrosis: an unusual entity producing complete lacrimal duct obstruction. (16754230)
2006
6
The clinical value of dacryoscintigraphy in the selection of surgical approach for patients with functional lacrimal duct obstruction. (16248384)
2005
7
Diagnostic Ophthalmology. Left dacryocystitis with naso-lacrimal duct obstruction. (15600163)
2004
8
Dilatation and stenting for naso-lacrimal duct obstruction: a pilot project. (10551300)
1999
9
Bacteriology of lacrimal duct obstruction in adults. (9135406)
1997
10
Silicone intubation for the treatment of congenital lacrimal duct obstruction: successful results removing the tubes after six weeks. (3211482)
1988
11
CORTICOSTEROIDS AND FIBROLYSIN IN THE PREVENTION OF LACRIMAL DUCT OBSTRUCTION. (18170750)
1962
12
The management of lacrimal duct obstruction. (14824621)
1951

Variations for Lacrimal Duct Obstruction

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Expression for genes affiliated with Lacrimal Duct Obstruction

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Search GEO for disease gene expression data for Lacrimal Duct Obstruction.

Pathways for genes affiliated with Lacrimal Duct Obstruction

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Pathways related to Lacrimal Duct Obstruction according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1SIX1, EYA1

Compounds for genes affiliated with Lacrimal Duct Obstruction

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GO Terms for genes affiliated with Lacrimal Duct Obstruction

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Biological processes related to Lacrimal Duct Obstruction according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of secondary heart field cardioblast proliferationGO:00725139.4SIX1, EYA1
2aorta morphogenesisGO:00359099.4SIX1, EYA1
3neuron fate specificationGO:00486659.4SIX1, EYA1
4pharyngeal system developmentGO:00600379.4EYA1, SIX1
5regulation of neuron differentiationGO:00456649.3SIX1, EYA1
6cochlea morphogenesisGO:00901039.3SIX1, EYA1
7middle ear morphogenesisGO:00424749.3EYA1, SIX1
8outflow tract morphogenesisGO:00031519.2SIX1, EYA1
9embryonic skeletal system morphogenesisGO:00487049.2SIX1, EYA1
10branching involved in ureteric bud morphogenesisGO:00016589.1SIX1, EYA1
11pattern specification processGO:00073899.0EYA1, SIX1
12sensory perception of soundGO:00076058.8SIX1, EYA1
13transcription, DNA-templatedGO:00063518.5SIX5, SIX1, EYA1

Molecular functions related to Lacrimal Duct Obstruction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:00435659.0SIX5, SIX1

Products for genes affiliated with Lacrimal Duct Obstruction

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  • Antibodies
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Sources for Lacrimal Duct Obstruction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet