Lactate Dehydrogenase Deficiency malady

Genetics Home Reference: Lactate dehydrogenase deficiency is a condition that affects how the body breaks down sugar to use as energy in cells, primarily muscle cells.¹⁷

MalaCards: Lactate Dehydrogenase Deficiency, also known as deficiency of l-lactate dehydrogenase, is related to lactate dehydrogenase-b deficiency and photosensitive trichothiodystrophy. An important gene associated with Lactate Dehydrogenase Deficiency is LDHA (lactate dehydrogenase A), and among its related pathways are Metabolic States and Circadian Oscillators and Propanoate metabolism. The compounds Oxamic Acid and Nicotinamide-Adenine-Dinucleotide have been mentioned in the context of this disorder.

lactate dehydrogenase deficiency 30 17 deficiency of l-lactate dehydrogenase 43 deficiency of lactate dehydrogenase 17

ldh deficiency 17 malnutrition 43

Disease types for lactate dehydrogenase deficiency family:

lactate dehydrogenase-b deficiency	lactate dehydrogenase a deficiency
lactate dehydrogenase deficiency type c

Diseases related to lactate dehydrogenase deficiency by text searches and GeneDecks gene sharing:

(show top 50)    (show all 320)

id	Related Disease	Score	Top Affiliating Genes
1	lactate dehydrogenase-b deficiency	29.9	LDHA, LDHB
2	photosensitive trichothiodystrophy	24.5	LDHB, LDHA
3	chronic myeloproliferative disease	12.2	LDHA, LDHB
4	panic disorder	12.2	LDHA, LDHB
5	retinoblastoma	12.1	LDHA, LDHB
6	noma	12.0	LDHA, LDHB
7	renal carcinoma	11.8	LDHA, LDHB
8	protein-energy malnutrition	8.9
9	lactate dehydrogenase deficiency type c	7.7
10	peritonitis	7.5
11	fanconi-bickel syndrome	6.8
12	lactate dehydrogenase a deficiency	6.8
13	atherosclerosis	6.5
14	diabetes mellitus	6.5
15	alcoholism	6.3
16	hepatitis	6.3
17	anemia	6.0
18	anorexia nervosa	6.0
19	pancreatitis	6.0
20	carcinoma	5.6
21	diarrhea	5.6
22	insulin resistance	5.6
23	rickets	5.6
24	uremia	5.6
25	marasmus	5.1
26	nutritional deficiency disease	5.1
27	overnutrition	5.1
28	pulmonary disease	5.1
29	ancylostomiasis	5.1
30	chronic obstructive pulmonary disease	5.1
31	cystic fibrosis	5.1
32	fibrosis	5.1
33	hyperhomocysteinemia	5.1
34	immunodeficiency	5.1
35	kwashiorkor	5.1
36	liver cirrhosis	5.1
37	adenosine deaminase deficiency	4.2
38	apo a-i deficiency	4.2
39	biotinidase deficiency	4.2
40	cd4 deficiency	4.2
41	congenital muscular dystrophy multi-gene panels	4.2
42	caveolinopathies	4.2
43	eosinophil peroxidase deficiency	4.2
44	gaba aminotransferase deficiency	4.2
45	gamma chain deficiency	4.2
46	hartnup disease	4.2
47	interleukin 2 receptor alpha chain deficiency	4.2
48	lpa deficiency, congenital	4.2
49	mannose-binding protein deficiency	4.2
50	ornithine translocase deficiency	4.2

Approved drugs:

Drug clinical trials:

Articles related to lactate dehydrogenase deficiency:

id	Title	Authors	Year	Affiliating Genes
1	Population screening of lactate dehydrogenase deficiencies in Fukuoka Prefecture in Japan and molecular characterization of three independent mutations in the lactate dehydrogenase-B(H) gene. (8270259)	Maekawa M.... Kanno T.	1994	LDHA, LDHB

Genes related to lactate dehydrogenase deficiency according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	LDHA	lactate dehydrogenase A	11.0	Publications
2	LDHB	lactate dehydrogenase B	11.0	Publications

Pathways related to lactate dehydrogenase deficiency according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Metabolic States and Circadian Oscillators36	9.2	LDHB, LDHA
2	Propanoate metabolism20	9.1	LDHA, LDHB
3	Glycolysis / Gluconeogenesis20	9.1	LDHA, LDHB
4	Cysteine and methionine metabolism20	9.0	LDHB, LDHA
5	Pyruvate metabolism20	8.8	LDHA, LDHB

Compounds related to lactate dehydrogenase deficiency according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	Oxamic Acid9 9	10.2	LDHB, LDHA
2	Nicotinamide-Adenine-Dinucleotide9 9	10.1	LDHB, LDHA
3	lactate32	9.1	LDHB, LDHA
4	pyruvate32	9.0	LDHA, LDHB
5	nadh32 9 18 9	11.8	LDHA, LDHB

Biological processes related to lactate dehydrogenase deficiency according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	glycolysis	GO:006096	9.1	LDHA, LDHB
2	cellular carbohydrate metabolic process	GO:044262	9.0	LDHA, LDHB
3	pyruvate metabolic process	GO:006090	8.8	LDHA, LDHB

Molecular functions related to lactate dehydrogenase deficiency according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	L-lactate dehydrogenase activity	GO:004459	9.1	LDHA, LDHB