MCID: LCT001
MIFTS: 51

Lactic Acidosis

Categories: Rare diseases, Metabolic diseases

Aliases & Classifications for Lactic Acidosis

MalaCards integrated aliases for Lactic Acidosis:

Name: Lactic Acidosis 12 28 14
Acidosis, Lactic 41 69
Acidosis Lactic 51

Classifications:



External Ids:

Disease Ontology 12 DOID:3650
ICD10 32 E87.2
MeSH 41 D000140
NCIt 46 C98969
SNOMED-CT 64 91273001
UMLS 69 C0001125

Summaries for Lactic Acidosis

Disease Ontology : 12 An acquired metabolic disease that has material basis in low pH in body tissues and blood accompanied by the buildup of lactate especially D-lactate.

MalaCards based summary : Lactic Acidosis, also known as acidosis, lactic, is related to myopathy, lactic acidosis, and sideroblastic anemia 1 and myopathy, lactic acidosis, and sideroblastic anemia. An important gene associated with Lactic Acidosis is YARS2 (Tyrosyl-TRNA Synthetase 2), and among its related pathways/superpathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Metformin and Celecoxib have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and heart.

Wikipedia : 72 Lactic acidosis is a medical condition characterized by the buildup of lactate (especially L-lactate) in... more...

Related Diseases for Lactic Acidosis

Diseases in the Lactic Acidosis family:

Lactic Acidosis, Chronic Adult Form Lactic Acidosis Congenital Infantile

Diseases related to Lactic Acidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 282)
# Related Disease Score Top Affiliating Genes
1 myopathy, lactic acidosis, and sideroblastic anemia 1 34.3 PUS1 YARS2
2 myopathy, lactic acidosis, and sideroblastic anemia 33.8 MT-ATP6 PUS1 YARS2
3 pyruvate dehydrogenase e1-alpha deficiency 33.3 PC PDHA1 PDHX
4 encephalomyopathy 32.2 MT-CO3 MT-ND1 MT-ND4 MT-ND5
5 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 32.1 GTPBP3 LARS2 MT-ATP6 MT-CO3 MT-ND1 MT-ND4
6 mitochondrial myopathy 31.0 ISCU MT-ATP6 MT-CO3 MT-ND4 MT-ND5 POLG
7 mitochondrial encephalomyopathy 30.9 LARS2 MT-CO3 MT-ND1 MT-ND4 MT-ND5
8 sideroblastic anemia 30.7 LARS2 MT-ATP6 PUS1 YARS2
9 myopathy 30.3 ISCU MT-ATP6 MT-ND5 POLG PUS1 YARS2
10 alpha-ketoglutarate dehydrogenase deficiency 29.9 DLD PDHA1
11 leigh syndrome 29.3 DLD MT-ATP6 MT-CO3 MT-ND1 MT-ND4 MT-ND5
12 neuropathy 29.3 MT-ATP6 MT-ND1 MT-ND4 MT-ND5 POLG
13 mitochondrial disorders 28.7 MT-ATP6 MT-ND1 MT-ND4 MT-ND5 POLG RMND1
14 mitochondrial metabolism disease 27.4 COX14 MT-ATP6 MT-ND1 MT-ND4 MT-ND5 PDHA1
15 mitochondrial myopathy with lactic acidosis 12.5
16 myopathy with lactic acidosis, hereditary 12.5
17 myopathy, lactic acidosis, and sideroblastic anemia 2 12.5
18 hyperglycinemia, lactic acidosis, and seizures 12.4
19 hydrops, lactic acidosis, and sideroblastic anemia 12.4
20 encephalopathy, neonatal severe, with lactic acidosis and brain abnormalities 12.3
21 neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures 12.3
22 myopathy, lactic acidosis, and sideroblastic anemia 3 12.3
23 lactic acidosis congenital infantile 12.1
24 lactic acidosis, chronic adult form 12.1
25 succinic acidemia lactic acidosis congenital 12.1
26 pyruvate carboxylase deficiency 12.0
27 mitochondrial dna depletion syndrome 9 12.0
28 gracile syndrome 12.0
29 dihydrolipoamide dehydrogenase deficiency 11.9
30 combined oxidative phosphorylation deficiency 10 11.8
31 maple syrup urine disease 11.8
32 combined oxidative phosphorylation deficiency 18 11.7
33 mitochondrial phosphate carrier deficiency 11.6
34 combined oxidative phosphorylation deficiency 19 11.6
35 pyruvate dehydrogenase phosphatase deficiency 11.4
36 myopathy with deficiency of iron-sulfur cluster assembly enzyme 11.4
37 combined oxidative phosphorylation deficiency 3 11.4
38 mitochondrial complex iv deficiency 11.3
39 mitochondrial complex i deficiency 11.3
40 metabolic acidosis 11.3
41 mitochondrial complex iii deficiency 11.3
42 sengers syndrome 11.2
43 combined oxidative phosphorylation deficiency 2 11.2
44 hsd10 mitochondrial disease 11.1
45 barth syndrome 11.1
46 multiple mitochondrial dysfunctions syndrome 1 11.1
47 mitochondrial dna depletion syndrome 8a 11.1
48 pyruvate dehydrogenase e1-beta deficiency 11.1
49 combined oxidative phosphorylation deficiency 11 11.1
50 combined oxidative phosphorylation deficiency 14 11.1

Graphical network of the top 20 diseases related to Lactic Acidosis:



Diseases related to Lactic Acidosis

Symptoms & Phenotypes for Lactic Acidosis

Drugs & Therapeutics for Lactic Acidosis

Drugs for Lactic Acidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 125)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2 657-24-9 4091 14219
2
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
3 Parecoxib Approved Phase 4 198470-84-7
4
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
5
Adefovir Dipivoxil Approved, Investigational Phase 4 142340-99-6 60871
6
Telbivudine Approved, Investigational Phase 4 3424-98-4 159269
7
Stavudine Approved, Investigational Phase 4 3056-17-5 18283
8
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
9
Fenoldopam Approved Phase 4 67227-56-9, 67227-57-0 3341
10
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
11
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 59-30-3 6037
13
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
14
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 59-43-8 1130
15 Antipsychotic Agents Phase 4
16 Central Nervous System Depressants Phase 4
17 Hypoglycemic Agents Phase 4,Phase 3,Phase 2
18 Psychotropic Drugs Phase 4
19 Tranquilizing Agents Phase 4
20 Analgesics Phase 4
21 Analgesics, Non-Narcotic Phase 4
22 Analgesics, Opioid Phase 4
23 Anti-Inflammatory Agents Phase 4
24 Anti-Inflammatory Agents, Non-Steroidal Phase 4
25 Antirheumatic Agents Phase 4
26 Cyclooxygenase 2 Inhibitors Phase 4
27 Cyclooxygenase Inhibitors Phase 4
28 insulin Phase 4,Phase 2
29 Insulin, Globin Zinc Phase 4,Phase 2
30 Narcotics Phase 4
31 Peripheral Nervous System Agents Phase 4
32 Adefovir Phase 4
33 Anti-Infective Agents Phase 4
34 Anti-Retroviral Agents Phase 4
35 Antiviral Agents Phase 4
36 Liver Extracts Phase 4
37 Nucleic Acid Synthesis Inhibitors Phase 4
38 Reverse Transcriptase Inhibitors Phase 4
39 Vasodilator Agents Phase 4
40 Dermatologic Agents Phase 4
41 Micronutrients Phase 4,Phase 2,Phase 1
42 Photosensitizing Agents Phase 4
43 Trace Elements Phase 4,Phase 2,Phase 1
44 Vitamin B Complex Phase 4,Phase 1,Phase 2
45 Vitamins Phase 4,Phase 1,Phase 2
46 Antihypertensive Agents Phase 4
47 Dopamine Agents Phase 4
48 Dopamine agonists Phase 4
49 Neurotransmitter Agents Phase 4
50 Vaccines Phase 4

Interventional clinical trials:

(show top 50) (show all 60)

# Name Status NCT ID Phase Drugs
1 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4 Metformin
2 Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery Unknown status NCT01930318 Phase 4 parecoxib
3 Telbivudine Renoprotective Effect in Patients With the HBV-related Liver Cirrhosis: a Randomized Controlled Trial Unknown status NCT01799486 Phase 4 Telbivudine;Enecavir;Adefovir
4 Lactate Metabolism Study in HIV Infected Persons Completed NCT00202228 Phase 4 cofactor supplementation (thiamine, riboflavin, L-carnitine)
5 Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass Completed NCT00747331 Phase 4 Fenoldopam mesilate;Placebo
6 Responses to Influenza Vaccine in Patients With Mitochondrial Disorders (MELAS) Completed NCT01831934 Phase 4
7 Type 2 Diabetes and Ambulatory Surgery Patients Completed NCT03179254 Phase 4 Metformin continue;Metformin discontinue
8 The Metformin in Coronary Artery Bypass Graft (CABG) (MetCAB) Trial Completed NCT01438723 Phase 4 Metformin;Placebo
9 Body Weight Effects on Glucophage's Efficacy in Chinese Diagnosed T2DM Patients Completed NCT00778622 Phase 4 Metformin XR
10 Lactic Acidosis During Entecavir(ETV)Treatment Terminated NCT01354652 Phase 4 entecavir, lamivudine
11 Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis Completed NCT00004490 Phase 3 sodium dichloroacetate
12 RBC Transfusion in Severe Anemia With Lactic Acidosis Completed NCT01586923 Phase 3
13 Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency: Recruiting NCT02616484 Phase 3 Dichloroacetate (DCA)
14 Patients With Heart Failure ANd Type 2 Diabetes Treated With Placebo Or Metformin (PHANTOM) Pilot Study Terminated NCT00325910 Phase 3 Metformin
15 Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome Unknown status NCT00068913 Phase 2 Dichloroacetate
16 Study of Idebenone in the Treatment of Mitochondrial Encephalopathy Lactic Acidosis & Stroke-like Episodes Completed NCT00887562 Phase 2 Idebenone;Idebenone
17 Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock Patients Completed NCT01262196 Phase 2 MP4OX;Saline
18 Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients Completed NCT01004198 Phase 2 MP4OX;MP4OX;Ringers Lactate solution
19 Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia Completed NCT00004493 Phase 2 sodium dichloroacetate
20 SELESTIAL: Trial of Insulin to Control Blood Sugar After Acute Stroke Using Magnetic Resonance Imaging (MRI) End-Points Completed NCT00124826 Phase 2 Insulin
21 Thiamine as a Metabolic Resuscitator in Septic Shock Completed NCT01070810 Phase 1, Phase 2 D5W;Thiamine
22 The KHENERGY Study Completed NCT02909400 Phase 2 KH176;placebo
23 Metformin and Simvastatin in Addition to Fulvestrant Recruiting NCT03192293 Phase 2 Metformin/Simvastatin/Fulvestrant
24 Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest Recruiting NCT02974257 Phase 2 Thiamine
25 The Effects of Neoadjuvant Metformin on Tumour Cell Proliferation and Tumour Progression in Pancreatic Ductal Adenocarcinoma Not yet recruiting NCT02978547 Phase 2 Metformin Hydrochloride 500Mg Tablet
26 Metformin in Moderate and Severe Renal Failure (CKD 3-4): A Follow-up Study Not yet recruiting NCT02848508 Phase 2 Metformin
27 Phase 2c Dose Comparison Study of MP4OX in Trauma Withdrawn NCT01973504 Phase 2 MP4OX;Control
28 A Dose-escalating Clinical Trial With KH176 Completed NCT02544217 Phase 1 KH176;placebo
29 A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours Completed NCT00566410 Phase 1 Dichloroacetate
30 Thiamine Supplementation in Patients With Septic Shock Recruiting NCT03122678 Phase 1 Thiamine;Placebos
31 Nitroglycerin Infusion During Cardiac Surgery Unknown status NCT01901419 Nitroglycerin infusion
32 Mitochondrial nt3243 A>G Mutation in Taiwan Unknown status NCT02114554
33 Effect of Blood Storage Age on the Resolution of Lactic Acidosis in Children With Severe Malarial Anemia at Mulago Hospital Completed NCT01580111
34 Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media Completed NCT01873859 Metformin
35 Study On the Role of Mitochondrial Dysfunction in the Pathogenesis of Metformin-associated Lactic Acidosis Completed NCT00942123
36 Metformin Treatment, Renal Function and Lactic Acidosis Completed NCT01358994
37 Lactic Acidosis During and After Seizures Completed NCT01833247
38 Dichloroacetate Kinetics, Metabolism and Toxicology Completed NCT00015015 Dichloroacetate
39 Pharmacotoxicology of Trichloroethylene Metabolites Completed NCT00874276 Dichloroacetate (DCA)
40 Study of Blood Lactate Levels in Patients Treated With Antipsychotics Completed NCT01139463 Haloperidol or olanzapine
41 Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia Completed NCT00004353
42 Prevention of Dichloroacetate Toxicity Completed NCT00031161 Nitisinone (NTBC);Dichloroacetate
43 Effects of Polyphenols Supplementation on Cycling Endurance Completed NCT03214276
44 The Cytoadherence in Pediatric Malaria (CPM) Study Completed NCT00707200
45 Variation in Serum Levels of Metformin in Patients With Reduced Renal Function Completed NCT00767351
46 The Various Effects of Gaseous Albuterol on Serum Lactate Completed NCT02073747 Normal Saline;Albuterol
47 Investigation of the Correlation Between Plasma Concentration of Linezolid Antibiotic and Treatment Response and Adverse Reactions Recruiting NCT03126890
48 Lactate Acidosis in Postoperative Hearts Recruiting NCT03025659
49 Mitochondrial and Microbiota Relationship Recruiting NCT03213067
50 Metformin Use in Chronic Kidney Disease: The CKD-Met Study Recruiting NCT02844153

Search NIH Clinical Center for Lactic Acidosis

Cochrane evidence based reviews: acidosis, lactic

Genetic Tests for Lactic Acidosis

Genetic tests related to Lactic Acidosis:

# Genetic test Affiliating Genes
1 Lactic Acidosis 28

Anatomical Context for Lactic Acidosis

MalaCards organs/tissues related to Lactic Acidosis:

38
Kidney, Liver, Heart, B Cells, Testes, Lung, Brain

Publications for Lactic Acidosis

Articles related to Lactic Acidosis:

(show top 50) (show all 810)
# Title Authors Year
1
Altered Kinetics Properties of Erythrocyte Lactate Dehydrogenase in Type II Diabetic Patients and Its Implications for Lactic Acidosis. ( 29371768 )
2018
2
Recurrent lactic acidosis and hypoglycemia with inadvertent metformin use: a case of look-alike pills. ( 29340159 )
2018
3
Metformin-Associated Lactic Acidosis: A Case Report. ( 29427160 )
2018
4
Metformin-associated lactic acidosis mimicking ischaemic bowel. ( 29391354 )
2018
5
Defective mitochondrial ATPase due to rare mtDNA m.8969G>A mutation-causing lactic acidosis, intellectual disability, and poor growth. ( 29350304 )
2018
6
Conventional and Diffusional Magnetic Resonance Imaging Features of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes in Chinese Patients: A Study of 40 Cases. ( 29369945 )
2018
7
Comparative assessment of probiotics and monensin in the prophylaxis of acute ruminal lactic acidosis in sheep. ( 29316923 )
2018
8
Mammalian Cells Undergo Endoreduplication in Response to Lactic Acidosis. ( 29440645 )
2018
9
Survival analysis of a cohort of Chinese patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) based on clinical features. ( 29406897 )
2018
10
Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( 29301418 )
2018
11
Type B lactic acidosis, an uncommon paraneoplastic syndrome. ( 29293400 )
2018
12
Sea food consumption for improving cardiac and cerebral manifestations of mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes. ( 28936463 )
2017
13
Serum lactate level and mortality in metformin-associated lactic acidosis requiring renal replacement therapy: a systematic review of case reports and case series. ( 28693440 )
2017
14
Correction for Li and Guan, "Human Mitochondrial Leucyl-tRNA Synthetase Corrects Mitochondrial Dysfunctions Due to the tRNA(Leu(UUR)) A3243G Mutation, Associated with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Symptoms and Diabetes". ( 28847973 )
2017
15
Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children. ( 28914978 )
2017
16
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS) due to a m.10158T>C ND3 Mutation with a Normal Muscle Biopsy. ( 28883250 )
2017
17
Lactic acidosis as an infrequent manifestation of a pheocromocytoma. ( 27894603 )
2017
18
Retinal detachment and microangiopathy in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome. ( 29217043 )
2017
19
Combined metformin-associated lactic acidosis and euglycemic ketoacidosis. ( 28865058 )
2017
20
UQCRC2 mutation in a patient with mitochondrial complex III deficiency causing recurrent liver failure, lactic acidosis and hypoglycemia. ( 28275242 )
2017
21
Morphologic features of normoblasts in a case of myopathy, lactic acidosis, and sideroblastic anemia. ( 28232625 )
2017
22
D-lactic acidosis - case report and review of theA literature. ( 27723911 )
2017
23
Hypoglycemia and severe lactic acidosis in a dog following metformin exposure. ( 29225865 )
2017
24
Fatal lactic acidosis in hepatitis B virus-associated decompensated cirrhosis treated with tenofovir: A case report. ( 28640087 )
2017
25
Mitochondrial Encephalomyopathy With Lactic Acidosis and Stroke-Like Episodes-MELAS Syndrome. ( 29026367 )
2017
26
A Myopathy, Lactic Acidosis, Sideroblastic Anemia (Mlasa) Case Due to A Novel Pus1 Mutation. ( 28832011 )
2017
27
Unusual Case of Severe Lactic Acidosis in a Liver Transplant Patient. ( 29391965 )
2017
28
Examining clinical similarities between myalgic encephalomyelitis/chronic fatigue syndrome and D-lactic acidosis: a systematic review. ( 28592308 )
2017
29
Adult-onset Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke (MELAS)-like Encephalopathy Diagnosed Based on the Complete Sequencing of Mitochondrial DNA Extracted from Biopsied Muscle without any Myopathic Changes. ( 28050007 )
2017
30
A case of rhabdomyolysis after status epilepticus without stroke-like episodes in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. ( 28637934 )
2017
31
Targeting Oxygen-Sensing Prolyl Hydroxylase for Metformin-Associated Lactic Acidosis Treatment. ( 28606929 )
2017
32
Lactic Acidosis ( 29262026 )
2017
33
Further clarifying the relationship between metformin, acute kidney injury and lactic acidosis. ( 29234161 )
2017
34
Metformin-associated Lactic Acidosis Requiring Intensive Care in a Regional Hospital in Hong Kong and Predictive Factors for Mortality. ( 29307973 )
2017
35
Assessment of Nitric Oxide Production in Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes Syndrome with the Use of a Stable Isotope Tracer Infusion Technique. ( 28515163 )
2017
36
Lactic Acidosis and Mitral Valve Surgery: Defining the Relationship. ( 29310939 )
2017
37
Refractory Lactic Acidosis in Small Cell Carcinoma of the Lung. ( 28620552 )
2017
38
Prediction of long-term prognosis by heteroplasmy levels of the m.3243A>G mutation in patients with the mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome. ( 27869334 )
2017
39
Adult-onset of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome with hypothyroidism and psychiatric disorders. ( 29260009 )
2017
40
Lactic acidosis associated (or induced by) metformin. ( 28865920 )
2017
41
Diabetes mellitus: Complex interplay between metformin, AKI and lactic acidosis. ( 28736433 )
2017
42
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS) due to a m.10158T>C ND3 Mutation with a Normal Muscle Biopsy. ( 28883258 )
2017
43
Probiotics, D-Lactic Acidosis, Oxidative Stress and Strain Specificity. ( 28080206 )
2017
44
Still sour about lactic acidosis years later: role of metformin in heart failure. ( 28868582 )
2017
45
Gastro-intestinal Involvement in m.3243A>G-associated Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes. ( 29151541 )
2017
46
Low sensitivity of anion gap to detect clinically significant lactic acidosis in the emergency department. ( 28736054 )
2017
47
Uncommon mutation in mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS). ( 28242802 )
2017
48
Hemodialysis for Lactic Acidosis. ( 28904487 )
2017
49
Lactate levels and risk of lactic acidosis with metformin in diabetic kidney disease patients. ( 29265047 )
2017
50
Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus. ( 28656086 )
2017

Variations for Lactic Acidosis

Expression for Lactic Acidosis

Search GEO for disease gene expression data for Lactic Acidosis.

Pathways for Lactic Acidosis

Pathways related to Lactic Acidosis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 COX14 DLD ISCU MT-ATP6 MT-CO3 MT-ND1
2
Show member pathways
12.89 COX14 DLD MT-ATP6 MT-CO3 MT-ND1 MT-ND4
3
Show member pathways
12.36 DLD PC PDHA1 PDHX
4
Show member pathways
12.08 DLD PC PDHA1 SUCLG1
5
Show member pathways
11.67 DLD PDHA1 PDHX PDP1 SUCLG1
6
Show member pathways
11.64 DLD PC PDHA1 SUCLG1
7
Show member pathways
11.43 DLD PDHA1 PDHX
8
Show member pathways
11.2 DLD PC PDHA1
9
Show member pathways
11.16 DLD PDHA1 PDHX
10 11.06 DLD LARS2 PC PDHA1 PDHX SUCLG1
11 11 DLD SUCLG1

GO Terms for Lactic Acidosis

Cellular components related to Lactic Acidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.73 MT-ATP6 MT-CO3 MT-ND1 MT-ND4 MT-ND5 SUCLG1
2 mitochondrial matrix GO:0005759 9.65 DLD ISCU LARS2 PC PDHA1 PDHX
3 mitochondrion GO:0005739 9.6 COX14 DLD GTPBP3 ISCU LARS2 MT-CO3
4 mitochondrial membrane GO:0031966 9.58 COX14 MT-ND1 MT-ND4
5 respiratory chain GO:0070469 9.54 MT-ND1 MT-ND4 MT-ND5
6 mitochondrial respiratory chain complex I GO:0005747 9.5 MT-ND1 MT-ND4 MT-ND5
7 pyruvate dehydrogenase complex GO:0045254 9.33 DLD PDHA1 PDHX

Biological processes related to Lactic Acidosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.92 DLD MT-ND1 MT-ND4 MT-ND5 PDHA1
2 aging GO:0007568 9.73 DLD MT-ATP6 MT-ND4 POLG
3 tRNA processing GO:0008033 9.67 GTPBP3 MTO1 PUS1
4 mitochondrial respiratory chain complex I assembly GO:0032981 9.65 MT-ND1 MT-ND4 MT-ND5
5 mitochondrial electron transport, NADH to ubiquinone GO:0006120 9.56 DLD MT-ND1 MT-ND4 MT-ND5
6 tricarboxylic acid cycle GO:0006099 9.54 DLD PDHA1 SUCLG1
7 response to hyperoxia GO:0055093 9.51 MT-ATP6 POLG
8 cellular nitrogen compound metabolic process GO:0034641 9.5 DLD PDHA1 PDHX
9 ATP synthesis coupled electron transport GO:0042773 9.46 MT-ND4 MT-ND5
10 acetyl-CoA biosynthetic process from pyruvate GO:0006086 9.4 DLD PDHA1
11 mitochondrial acetyl-CoA biosynthetic process from pyruvate GO:0061732 9.33 DLD PDHA1 PDHX
12 pyruvate metabolic process GO:0006090 9.26 DLD PC PDHA1 PDHX
13 regulation of acetyl-CoA biosynthetic process from pyruvate GO:0010510 8.92 DLD PDHA1 PDHX PDP1

Molecular functions related to Lactic Acidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.65 DLD MT-ND1 MT-ND4 MT-ND5 PDHA1
2 ligase activity GO:0016874 9.46 LARS2 PC SUCLG1 YARS2
3 NADH dehydrogenase (ubiquinone) activity GO:0008137 9.13 MT-ND1 MT-ND4 MT-ND5
4 pyruvate dehydrogenase (NAD+) activity GO:0034604 8.8 DLD PDHA1 PDHX

Sources for Lactic Acidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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