Lactic Acidosis malady

Disease Ontology: An acquired metabolic disease that has material basis in low ph in body tissues and blood accompanied by the buildup of lactate especially d-lactate.⁶

MalaCards: Lactic Acidosis, also known as lactic acidosis (disorder), is related to mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes and melas syndrome. An important gene associated with Lactic Acidosis is YARS2 (tyrosyl-tRNA synthetase 2, mitochondrial), and among its related pathways are Metabolic pathways and Regulation of pyruvate dehydrogenase (PDH) complex. The drugs arginine hydrochloride and arginine and the compounds atp and 2-oxo acid have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and liver, and related mouse phenotypes are growth/size and cardiovascular system.

Wikipedia: Lactic acidosis is a physiological condition characterized by low pH in body tissues and blood...⁴⁴ more...

Aliases & Descriptions:

lactic acidosis 6 8 lactic acidosis (disorder) 6 acidosis, lactic 43

acidosis lactic 32 acidosis 43

Diseases related to lactic acidosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 461)

id	Related Disease	Score	Top Affiliating Genes
1	mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes	35.4	MT-ND5, MT-TK, MT-TL1, MT-ND4, MT-ND1, MT-ND6
2	melas syndrome	34.6	CKAP5, MT-ND5, MT-ND4, MT-CO3, MT-ND6, NDUFS4
3	fatal infantile lactic acidosis	34.3	MT-ND1, SUCLG1, NDUFS4, NME4
4	mitochondrial encephalomyopathy	33.4	MT-TK, MT-TL1, MT-ND4, MT-ATP6, MT-ND1, MT-ND6
5	pyruvate decarboxylase deficiency	32.9	PC, DLAT, PDHA1, PDHB, PDHX
6	sideroblastic anemia	31.0	YARS2, MT-CO1, ISCU, SUCLA2, COX5A, PUS1
7	mitochondrial complex iii deficiency	30.7	BCS1L, UQCRB, UQCRQ
8	alpha-ketoglutarate dehydrogenase deficiency	30.6	DLD, PDHA1, OGDH
9	mitochondrial complex i deficiency	30.5	MT-ND5, MT-ND1, MT-ND6, NDUFA1, NDUFA11, NDUFS4
10	maple syrup urine disease	29.7	ALB, CAT, DLD, OGDH, HADHA
11	encephalomyopathy	29.2	BCS1L, MT-ND5, MT-TK, MT-TL1, MT-CO1, MT-CO2
12	leigh disease	29.2	BCS1L, SCO2, MT-ND5, MT-CO1, MT-ND4, MT-ATP6
13	hypoglycemia	29.1	PC, PCK2, PCK1, INS, FBP1, IGF1
14	diabetic ketoacidosis	28.7	BGLAP, INS, IL10, ALB, CALCA
15	seizures	28.4	MT-ND5, MT-CO1, MT-ND4, MT-ATP6, MT-ND1, MT-ND6
16	myopathy	27.9	YARS2, MT-ND5, MT-TK, MT-TL1, MT-CO1, MT-CO2
17	growth hormone deficiency	27.5	BGLAP, INS, IGF1, F2, ALB, CALCA
18	hearing loss	27.3	BCS1L, CKAP5, MT-ND5, MT-TK, MT-TL1, MT-CO1
19	sensorineural hearing loss	27.2	BCS1L, CKAP5, MT-ND5, MT-TL1, MT-CO1, MT-ATP6
20	cataract	26.1	MT-CYB, AUH, INS, GPT, IGF1, ALB
21	glaucoma	26.1	MT-ND4, MT-ATP6, MT-CO3, MT-ND1, MT-ND6, IL10
22	hypertrophic cardiomyopathy	26.0	SCO2, MT-CO1, MT-CO2, MT-CO3, MT-CYB, MT-ND1
23	alcoholism	25.8	CFTR, ARSA, GPT, AKR1A1, GHRH, HMGCR
24	hypercalciuria	25.7	BGLAP, ALB, CALCA, TNF, SLC17A5
25	aortic aneurysm	25.6	IL10, F2, ALB, CAT, HMGCR, TNF
26	hyperglycemia	25.5	PCK2, PCK1, BGLAP, INS, IL10, FBP1
27	non-hodgkin lymphoma	25.3	MT-CO2, INS, IL10, GPT, IGF1, ALB
28	anemia	25.1	BCS1L, YARS2, MT-CO1, MT-ATP6, INS, IL10
29	hypothyroidism	25.0	BGLAP, INS, IL10, GPT, IGF1, F2
30	vaginitis	24.6	BGLAP, INS, IL10, F2, TNF, DLAT
31	cerebritis	24.5	PC, BGLAP, MT-ND5, MT-ND4, MT-CYB, MT-ND1
32	retinitis	24.2	MT-ND5, MT-ND4, MT-ATP6, MT-CYB, MT-ND1, MT-ND6
33	ischemia	23.8	PC, MT-CO1, MT-CYB, ATP5E, INS, IL10
34	hyperparathyroidism	23.7	BGLAP, CFTR, INS, IL10, GPT, IGF1
35	diarrhea	23.6	CFTR, INS, IL10, GPT, F2, ALB
36	acute pancreatitis	23.5	CFTR, INS, IL10, GPT, F2, ALB
37	neuropathy	23.3	PC, BCS1L, SCO2, MT-ND5, MT-CO1, MT-ND4
38	nephrotic syndrome	23.2	INS, IL10, FBP1, GPT, IGF1, F2
39	hepatitis	23.2	PC, PCK2, PCK1, BGLAP, CKAP5, MT-CO1
40	glioblastoma	22.9	MT-CO2, MT-ND4, MT-ATP6, MT-CO3, MT-ND1, IL10
41	insulin resistance	22.9	PCK2, PCK1, LIAS, BGLAP, MT-ND1, INS
42	osteoporosis	22.8	BGLAP, CFTR, INS, IL10, IGF1, F2
43	hypoxia	22.5	PC, PCK2, BGLAP, MT-ND5, MT-CO2, MT-ND4
44	peritonitis	22.4	BGLAP, MT-CYB, MRRF, INS, IL10, GPT
45	pancreatic cancer	21.7	BGLAP, UQCRB, CFTR, INS, IL10, GPT
46	diabetes mellitus	21.6	PC, PCK2, PCK1, BGLAP, MT-ND5, MT-TL1
47	thyroiditis	21.6	PCK2, PCK1, BGLAP, UQCRB, MT-ND5, MT-CO1
48	neuronitis	20.1	PC, PCK2, PCK1, UQCRQ, MT-CO1, MT-CO2
49	pancreatitis	19.5	PC, BGLAP, UQCRB, MT-TL1, MT-CO2, CFTR
50	breast cancer	19.1	BGLAP, BCS1L, CKAP5, MT-ND5, MT-CO2, MT-CYB

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 arginine, arginine hydrochloride, citrate, potassium citrate, sodium acetate, sodium acetate,anhydrous, sodium lactate, tromethamine

MalaCards organs/tissues related to lactic acidosis:

²²

MGI Mouse Phenotypes related to lactic acidosis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size phenotype	MP:0005378	INF	SPINK1, RPS6KA3, PDHA1, NDUFS4, NDUFS6, G6PC
2	cardiovascular system phenotype	MP:0005385	INF	PFKM, PDHA1, NDUFS4, NDUFS6, , OXT
3	mortality/aging	MP:0010768	INF	SPINK1, PFKM, PDHA1, NDUFS6, G6PC,
4	homeostasis/metabolism phenotype	MP:0005376	INF	HADHA, TXNIP, TNF, SURF1, SPINK1, RPS6KA3
5	muscle phenotype	MP:0005369	INF	NDUFS4, NDUFS6, , POLG, SLC25A4, RRM2B
6	liver/biliary system phenotype	MP:0005370	INF	TXNIP, TNF, RPS6KA3, G6PC, , RRM2B

Articles related to lactic acidosis:

(show top 50)    (show all 71)

id	Title	Authors	Year	Affiliating Genes
1	Mutations in C12orf62, a factor that couples COX I sy nthesis with cytochrome c oxidase assembly, cause fatal neonatal lactic acidosi s. (22243966)	Weraarpachai W.... Shoubridge E.A.	2012	COX14
2	Potential role of NHE1 (sodium-hydrogen exchanger 1) in the cellular dysfunction of lactic acidosis: implications for treatment. (21349616)	Wu D.... Kraut J.A.	2011	SLC9A1
3	Mutation of the mitochondrial tyrosyl-tRNA synthetase gene, YARS2, causes myopathy, lactic acidosis, and sideroblastic anemia--MLASA syndrome. (20598274)	Riley L.G.... Christodoulou J.	2010	YARS2
4	Lactic acidosis triggers starvation response with par adoxical induction of TXNIP through MondoA. (20844768)	Chen J.L.... Chi J.T.	2010	TXNIP, MLXIP
5	Type B lactic acidosis and insulin-resistant hyperglycemia in an adolescent following cardiac surgery. (18477905)	Parsapour K.... Pretzlaff R.	2008	INS
6	Myopathy with lactic acidosis is linked to chromosome 12q23.3-24.11 and caused by an intron mutation in the ISCU gene resulting in a splicing defect. (18296749)	Olsson A.... Holmberg M.	2008	ISCU
7	Toxicogenetics of antiretroviral treatment (II): neurotoxicity, hepatotoxicity, lactic acidosis, kidney damage, and other adverse effects of antiretroviral drugs. (18680693)	SA!nchez HellA-n V.... GutiAcrrez Rodero F.	2008	CFTR, POLG, SPINK1
8	Non-islet-cell tumor hypoglycemia and lactic acidosis in a child with congenital HIV and Burkitt's lymphoma. (18825882)	Rastogi M.V.... Quintos J.B.	2008	IGF1
9	Diagnostic accuracy of blood lactate-to-pyruvate molar ratio in the differential diagnosis of congenital lactic acidosis. (17384007)	Debray F.G.... Lambert M.	2007	PDP1
10	Deficiency of the alpha subunit of succinate-coenzyme A ligase causes fatal infantile lactic acidosis with mitochondrial DNA depletion. (17668387)	Ostergaard E.... Wibrand F.	2007	NME4, SUCLG1
11	Detection of common disease-causing mutations in mitochondrial DNA (mitochondrial encephalomyopathy, lactic acidosis with stroke-like episodes MTTL1 3243 A>G and myoclonic epilepsy associated with ragged-red fibers MTTK 8344A>G) by real-time polymerase chain reaction. (16645216)	Fan H.... Farber R.A.	2006	MT-TL1, MT-TK
12	Hypertrophic cardiomyopathy, cataract, developmental delay, lactic acidosis: a novel subtype of 3-methylglutaconic aciduria. (16736096)	Di Rosa G.... Dionisi-Vici C.	2006	AUH
13	Interstitial lactic acidosis in the graft during organ harvest, cold storage, and reperfusion of human liver allografts predicts subsequent ischemia reperfusion injury. (16858286)	Silva M.A.... Mirza D.F.	2006	SLC17A5
14	Sporadic intragenic inversion of the mitochondrial DNA MTND1 gene causing fatal infantile lactic acidosis. (16492986)	Blakely E.L.... Taylor R.W.	2006	MT-ND1
15	Bone calcium changes during diabetic ketoacidosis: a comparison with lactic acidosis due to volume depletion. (15869925)	Topaloglu A.K.... Ozer G.	2005	CALCA, INS, BGLAP
16	The SR protein SC35 is responsible for aberrant splicing of the E1alpha pyruvate dehydrogenase mRNA in a case of mental retardation with lactic acidosis. (15798212)	Gabut M.... Soret J.	2005	SRSF2
17	Mitochondrial myopathy, sideroblastic anemia, and lactic acidosis: an autosomal recessive syndrome in Persian Jews caused by a mutation in the PUS1 gene. (15971356)	Zeharia A.... Lerman-Sagie T.	2005	PUS1
18	Lactic acidosis in diabetic patient treated with met formin (15283644)	Solano RemA-rez M.... Echegaray Agara M.	2004	INS
19	Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis. (14662656)	Grad L.I.... Lemire B.D.	2004	NDUFV1, NDUFS4
20	Dysfunctional labor and myometrial lactic acidosis. (15051564)	Quenby S.... Wray S.	2004	OXT
21	Lactic acidosis in HIV-patients--diagnosis and treatment (15373054)	Walker U.A.	2004	POLG
22	Splicing error in E1alpha pyruvate dehydrogenase mRNA caused by novel intronic mutation responsible for lactic acidosis and mental retardation. (12551913)	Mine M.... Marsac C.	2003	PDP1
23	Hypothalamic growth hormone deficiency and supplementary GH therapy in two patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes. (12536371)	Matsuzaki M.... Hirayama Y.	2002	GHRH
24	Childhood onset mitochondrial myopathy and lactic acidosis caused by a stop mutation in the mitochondrial cytochrome c oxidase III gene. (12414820)	Horvath R.... Jaksch M.	2002	MT-CO3
25	Lactic acidosis after cardiac surgery is associated with polymorphisms in tumor necrosis factor and interleukin 10 genes. (12078789)	Ryan T.... Smith O.P.	2002	TNF, IL10
26	Lack of correlation between length variation in the DNA polymerase gamma gene CAG repeat and lactic acidosis or neuropathy during antiretroviral treatment. (12036482)	Chen X.... van der Kuyl A.C.	2002	POLG
27	Severe lactic acidosis caused by a novel frame-shift mutation in mitochondrial-encoded cytochrome c oxidase subunit II. (11471180)	Wong L.J.... Chen T.J.	2001	MT-CO2
28	Riboflavin treatment of antiretroviral induced lactic acidosis and hepatic steatosis. (11508132)	Posteraro A.F.... Winter S.M.	2001	POLG
29	A rare etiology of hepatic steatosis associated with lactic acidosis: the toxicity of antiviral nucleoside analogues (11373588)	Bienvenu L.... Hofman P.	2001	POLG2
30	Unique astrocytic inclusion in a 2 month-old baby showing Leigh-like brain lesions with lactic acidosis. (10838110)	Yamamoto T.... Kobayashi M.	2000	CAT
31	Fatal lactic acidosis in a patient infected by HIV a nd treated with stavudine and didanosine (10949849)	MAcgarbane B.... Baud F.	2000	POLG
32	Ketoacidosis accompanied by epileptic seizures in a patient with diabetes mellitus and mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). (11119021)	Nakamura S.... Fujishima M.	2000	INS
33	Zidovudine-induced mitochondrial disorder with massiv e liver steatosis, myopathy, lactic acidosis, and mitochondrial DNA depletion. (9927163)	Chariot P.... Zafrani E.S.	1999	GPT
34	Nuclear DNA origin of mitochondrial complex I deficie ncy in fatal infantile lactic acidosis evidenced by transnuclear complementatio n of cultured fibroblasts. (10393702)	Procaccio V.... Issartel J.P.	1999	NDUFS4
35	Mouse mutants carrying deletions that remove the genes mutated in Coffin-Lowry syndrome and lactic acidosis. (9467016)	Blair H.J.... Boyd Y.	1998	RPS6KA3, PDHA1
36	Lactic acidosis in long-chain fatty acid beta-oxidati on disorders. (9762600)	Ventura F.V.... Wanders R.J.	1998	HADHA
37	Delayed posthypoxic demyelination. Association with arylsulfatase A deficiency and lactic acidosis on proton MR spectroscopy. (9371929)	Gottfried J.A.... Duyn J.H.	1997	ARSA
38	Mutations in PDX1, the human lipoyl-containing component X of the pyruvate dehydrogenase-complex gene on chromosome 11p1, in congenital lactic acidosis. (9399911)	Aral B.... Marsac C.	1997	PDHX
39	Lactic acidosis and hypoglycemia in a patient with hi gh-grade non-Hodgkin's lymphoma and elevated circulating TNF-alpha. (8597616)	Durig J.... Hossfeld D.K.	1996	TNF
40	Deficiency of the adenine nucleotide translocator in muscle of a patient with myopathy and lactic acidosis: a new mitochondrial defect. (8479824)	Bakker H.D.... Van Gennip A.H.	1993	OGDH, SLC25A4, ATP5E
41	Lactic acidosis and mitochondrial dysfunction in two children with peroxisomal disorders. (8105143)	Holmes R.D.... Kiechle F.L.	1993	PDP1
42	Neurodevelopmental abnormalities and lactic acidosis in a girl with a 20-bp deletion in the X-linked pyruvate dehydrogenase E1 alpha subunit gene. (7692352)	Matthews P.M.... Brown G.K.	1993	PDHA1
43	Alpha-ketoglutarate dehydrogenase deficiency presenting as congenital lactic acidosis. (1640293)	Bonnefont J.P.... Munnich A.	1992	OGDH
44	A new disease-related mutation for mitochondrial encephalopathy lactic acidosis and strokelike episodes (MELAS) syndrome affects the ND4 subunit of the respiratory complex I. (1323207)	Lertrit P.... Marzuki S.	1992	MT-ND4
45	Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis. (1343563)	Cooper D.J.... Russell J.A.	1992	ALB
46	Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) associated with hypothalamo-pituitary hypofunctio n--a case report (2060243)	Ishii A.... Kanazawa I.	1991	GH1, GHRH
47	Deficiency of the alpha and beta subunits of pyruvate dehydrogenase in a patient with lactic acidosis and unexpected sudden death. (2189731)	Sperl W.... Bakkeren J.A.	1990	DLD
48	Lactic acidosis increases tumor necrosis factor secre tion and transcription in vitro. (2214745)	Jensen J.C.... Norton J.A.	1990	TNF
49	Acute renal failure with lactic acidosis (2214321)	Ando M.... Shimizu K.	1990	F2
50	Congenital lactic acidosis, alpha-ketoglutaric aciduria and variant form of maple syrup urine disease due to a single enzyme defect: dihydrolipoyl dehydrogenase deficiency. (6897145)	Munnich A.... Robinson B.H.	1982	DLD

Genes related to lactic acidosis according to GeneCards:

(show top 50)    (show all 97)

id	Symbol	Description	Score	GeneCards Section Context
1	YARS2	tyrosyl-tRNA synthetase 2, mitochondrial	11.1	Publications, Summaries
2	MELAS	mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes	11.1	Aliases & Descriptions
3	SUCLG1	succinate-CoA ligase, alpha subunit	11.1	Publications, Summaries
4	DLAT	dihydrolipoamide S-acetyltransferase	11.1	Summaries, Orthologs
5	PDHX	pyruvate dehydrogenase complex, component X	11.1	Publications, Summaries
6	TUFM	Tu translation elongation factor, mitochondrial	11.1	Summaries
7	MT-ND1	mitochondrially encoded NADH dehydrogenase 1	11.0	Publications
8	MT-TK	mitochondrially encoded tRNA lysine	11.0	Publications
9	MT-TL1	mitochondrially encoded tRNA leucine 1 (UUA/G)	11.0	Publications
10	ISCU	iron-sulfur cluster scaffold homolog (E. coli)	11.0	Publications
11	PDP1	pyruvate dehyrogenase phosphatase catalytic subunit 1	11.0	Publications
12	NME4	NME/NM23 nucleoside diphosphate kinase 4	11.0	Publications
13	DLD	dihydrolipoamide dehydrogenase	11.0	Publications
14	GHRH	growth hormone releasing hormone	11.0	Publications
15	NDUFS4	NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)	11.0	Publications
16	GH1	growth hormone 1	11.0	Publications
17	MT-CO3	mitochondrially encoded cytochrome c oxidase III	11.0	Publications
18	MT-ND5	mitochondrially encoded NADH dehydrogenase 5	11.0
19	MT-ND6	mitochondrially encoded NADH dehydrogenase 6	11.0
20	MT-ND4	mitochondrially encoded NADH dehydrogenase 4	11.0	Publications
21	TRNAL1	transfer RNA leucine 1 (anticodon AAG)	11.0	Publications
22	MLXIP	MLX interacting protein	11.0	Publications
23	UQCRQ	ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa	11.0	Publications
24	BCS1L	BCS1-like (S. cerevisiae)	11.0
25	COX14	COX14 cytochrome c oxidase assembly homolog (S. cerevisiae)	11.0	Publications
26	PDHA1	pyruvate dehydrogenase (lipoamide) alpha 1	11.0	Publications
27	SCO2	SCO cytochrome oxidase deficient homolog 2 (yeast)	11.0
28	BOLA3	bolA homolog 3 (E. coli)	11.0
29	PDHB	pyruvate dehydrogenase (lipoamide) beta	11.0
30	UQCRB	ubiquinol-cytochrome c reductase binding protein	11.0	Publications
31	TMEM70	transmembrane protein 70	11.0
32	POLG	polymerase (DNA directed), gamma	11.0	Publications
33	NPTX2	neuronal pentraxin II	11.0
34	PC	pyruvate carboxylase	11.0	Orthologs, Publications
35	PDHA2	pyruvate dehydrogenase (lipoamide) alpha 2	11.0
36	NDUFA11	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa	11.0
37	PUS1	pseudouridylate synthase 1	11.0	Publications
38	NDUFA1	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa	11.0
39	ATP5E	ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit	11.0	Publications
40	ATPAF2	ATP synthase mitochondrial F1 complex assembly factor 2	11.0
41	COX7A2L	cytochrome c oxidase subunit VIIa polypeptide 2 like	11.0
42	ARRDC4	arrestin domain containing 4	11.0
43	PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	11.0
44	TXNIP	thioredoxin interacting protein	11.0	Publications
45	FBP1	fructose-1,6-bisphosphatase 1	11.0	Publications
46	POLG2	polymerase (DNA directed), gamma 2, accessory subunit	11.0	Publications
47	NFU1	NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)	11.0
48	GSTZ1	glutathione S-transferase zeta 1	11.0
49	NDUFS6	NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)	11.0
50	OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	11.0	Publications

Pathways related to lactic acidosis according to GeneDecks:

(show all 18)

id	Pathway	Score	Top Affiliating Genes
1	Metabolic pathways20	INF	PC, CAT, AKR1A1, HMGCR, TPK1, DLAT
2	Regulation of pyruvate dehydrogenase (PDH) complex38	10.6	PDP1, PDHX, PDHB, PDHA1, DLD, DLAT
3	Pyruvate metabolism20	10.4	PDHB, PDHA2, PDHA1, DLD, DLAT, PCK1
4	Valine, leucine and isoleucine biosynthesis20	10.3	LARS2, PDHA1, PDHA2, PDHB
5	Citrate cycle (TCA cycle)20	10.2	PC, PCK2, PCK1, DLAT, DLD, SUCLA2
6	Glucose metabolism38	10.1	FBP1, PCK1, PCK2, PC
7	Metformin Pathway, Pharmacodynamic34	10.1	NDUFV1, NDUFS6, NDUFS4, NDUFA11, NDUFA1, HMGCR
8	Glycolysis and gluconeogenesis (short map)41	10.0	G6PC, PFKM, FBP1, PCK1, PCK2, PC
9	Glycolysis and gluconeogenesis (short map)10	10.0	G6PC, PFKM, FBP1, PCK1, PC
10	Butanoate metabolism20	9.9	PDHA1, PDHA2, PDHB, HADHA
11	Glycolysis / Gluconeogenesis20	9.9	G6PC, PDHB, PDHA2, PDHA1, PFKM, DLD
12	Cardiac muscle contraction20	9.1	SLC9A1, COX7A2L, COX5A, MT-CYB, MT-CO3, MT-CO2
13	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.38	8.9	MT-CYB, MT-ND1, MT-ND6, ATP5E, COX5A, COX7A2L
14	Oxidative phosphorylation20	8.9	MT-ND1, MT-ND6, ATP5E, COX5A, COX7A2L, NDUFA1
15	Cellular Apoptosis Pathway36	8.7	RPS6KA3, CYCS, TNF, GHRH, GH1, IGF1
16	Huntingtons disease20	8.5	NDUFA1, NDUFA11, NDUFS4, NDUFS6, NDUFV1, SLC25A4
17	Parkinsons disease20	8.4	ATP5E, CYCS, COX5A, COX7A2L, NDUFA1, NDUFA11
18	Alzheimers disease20	8.2	UQCRB, UQCRQ, MT-CO1, MT-CO2, MT-ATP6, MT-CO3

Compounds related to lactic acidosis according to GeneDecks:

(show top 50)    (show all 141)

id	Compound	Score	Top Affiliating Genes
1	atp32	INF	POLG2, SLC25A4, NDUFS4, PDP1, PDHA1, PFKM
2	2-oxo acid32	10.7	DLD, DLAT, OGDH, PDP1, PDHX
3	dihydrolipoamide32 18	11.7	PDP1, DLAT, DLD, OGDH, PDHX
4	thiamine pyrophosphate32 18	11.4	PDHA1, PDHA2, PDP1, TPK1, PDHB, OGDH
5	Pyruvic acid9 18 9	12.4	DLD, DLAT, PDHB, PDHA2, PDHA1, GPT
6	Coenzyme A9 18 9	12.2	SUCLA2, OGDH, DLD, DLAT, HMGCR, PDHA2
7	thiamine32 9 18 9	12.9	TPK1, PDHA1, G6PC, OGDH, SLC17A5, AKR1A1
8	alpha-ketoglutarate32	9.9	GPT, TPK1, DLAT, DLD, PDHX, PDP1
9	malate32	9.9	COX5A, AKR1A1, GPT, PCK2, PC, OGDH
10	beta-hydroxybutyrate32	9.8	PC, GH1, SLC17A5, G6PC, INS
11	citrinin32	9.7	CAT, NDUFS4, CYCS, MT-CYB
12	peroxynitrite32	9.6	COX5A, DLD, OGDH, NDUFS4, CYCS, CAT
13	ubiquinone32	9.5	AKR1A1, HMGCR, CYCS, NDUFS4, HADHA, MT-ND4
14	pyruvate32	9.5	HADHA, SLC25A3, OGDH, G6PC, NDUFS4, PDHX
15	fluoride32	9.5	GH1, CFTR, CALCA, BGLAP, SPINK1, OXT
16	n acetylcysteine32	9.5	F2, HMGCR, GPT, CFTR, TXNIP, SLC17A5
17	hepaplastin32	9.4	F2, GPT, ALB, SLC17A5
18	glycerol32 9 18 9	12.4	INS, CFTR, PCK1, PCK2, PC, GH1
19	lamivudine32 9 9	11.3	POLG, SLC17A5, IL10, GPT, F2, POLG2
20	succinate32	9.3	CYCS, MT-CO1, MT-ND4, MT-CYB, AKR1A1, COX5A
21	bicarbonate32	9.3	SLC9A1, SURF1, ALB, AKR1A1, PC, CFTR
22	carnitine32	9.2	PC, PCK2, PCK1, SLC25A3, SLC17A5, OGDH
23	aspartate32	9.2	F2, GH1, G6PC, OXT, OGDH, ARSA
24	acipimox32	9.1	IGF1, INS, HMGCR, GHRH, GH1
25	nash32	9.0	INS, GPT, AKR1A1, TNF, SLC17A5
26	N-Formylmethionine9 9	10.0	MT-CO1, COX5A, MT-CO3, MT-CO2, MT-ND1
27	glycogen32 18	10.0	PFKM, GPT, INS, PCK1, OGDH, PC
28	epinephrine32 9 18 9	11.7	SLC9A1, CFTR, SLC17A5, F2, HMGCR, INS
29	fatty acid32	8.6	SLC17A5, HADHA, INS, PCK1, MT-CO1, PC
30	citrate32	8.6	MT-CO1, MT-CO2, MT-CO3, CFTR, CAT, AKR1A1
31	zidovudine32 9 9	10.5	SLC17A5, ALB, MT-CO2, IL10, GPT, POLG2
32	creatinine32	8.4	OGDH, HADHA, SLC25A4, OXT, PFKM, COX5A
33	glutamate32	8.3	PC, PCK2, CFTR, INS, OXT, NDUFS4
34	troglitazone32 42 9 9	11.3	PCK2, HMGCR, INS, G6PC, SLC17A5, GPT
35	glutamine32	8.1	GPT, IGF1, ARSA, CFTR, PCK2, PC
36	iron32 18	9.1	NDUFA1, NFU1, COX5A, NDUFS4, RRM2B, SLC17A5
37	methotrexate32 34 42 9 9	11.8	F2, SLC17A5, COX5A, IL10, GPT, ALB
38	alanine32	7.6	RPS6KA3, CFTR, ARSA, INS, GPT, ALB
39	h2o232	7.6	OXT, BGLAP, MT-CYB, SLC9A1, SLC17A5, OGDH
40	nadh32 9 18 9	10.5	COX5A, HADHA, PDHA1, PDHA2, PDHB, PDP1
41	thyroxine32 18	8.0	SLC17A5, GPT, OXT, HMGCR, IGF1, BGLAP
42	lactate32	5.4	GPT, INS, F2, ALB, CAT, OXT
43	serine32	INF	CYCS, OGDH, OXT, , PDP1, PDHX
44	alpha lipoic acid32	INF	DLAT, PC, , INS, CAT, OGDH
45	lipid32	INF	ALB, CAT, AKR1A1, GH1, GPT, INS
46	glucose32	INF	PDHX, MT-CO1, MT-ND4, MT-CO3, MT-CYB, MT-ND1
47	rotenone32	INF	CAT, , NDUFS4, CYCS, MT-ND6, MT-ND1
48	oxygen32 18	INF	POLG, MT-ATP6, MT-CO1, SCO2, SLC25A4, SLC17A5
49	adp32 18	INF	SLC25A4, PDP1, G6PC, , OGDH, POLG
50	superoxide32 18	INF	SCO2, CAT, PC, AKR1A1, TNF, CYCS

Cellular components related to lactic acidosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial nucleoid	GO:042645	10.2	TUFM, POLG, POLG2, HADHA
2	mitochondrial respiratory chain complex I	GO:005747	9.9	NDUFV1, NDUFS6, NDUFS4, NDUFA11, NDUFA1
3	mitochondrial matrix	GO:005759	9.6	DLAT, ATP5E, AUH, LARS2, YARS2, PCK2
4	mitochondrial inner membrane	GO:005743	9.0	HADHA, NME4, PC, UQCRB, UQCRQ, SCO2
5	mitochondrion	GO:005739	INF	HADHA, NFU1, PDHA1, NDUFA1, NDUFA11, NDUFS4

Biological processes related to lactic acidosis according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of acetyl-CoA biosynthetic process from pyruvate	GO:010510	10.6	PDP1, PDHX, PDHB, PDHA1, DLD, DLAT
2	pyruvate metabolic process	GO:006090	10.6	PDP1, PDHX, PDHB, PDHA1, DLD, DLAT
3	acetyl-CoA biosynthetic process from pyruvate	GO:006086	10.5	DLAT, DLD, PDHB
4	tricarboxylic acid cycle	GO:006099	10.3	OGDH, PDHB, SUCLG1, SUCLA2, DLD
5	mitochondrial electron transport, NADH to ubiquinone	GO:006120	10.3	NDUFV1, NDUFS6, NDUFS4, NDUFA1, DLD
6	glycolysis	GO:006096	10.3	OGDH, PDHB, PDHA2, PDHA1, PFKM, DLAT
7	oxaloacetate metabolic process	GO:006107	10.2	PC, PCK2, PCK1
8	gluconeogenesis	GO:006094	10.0	G6PC, GPT, FBP1, PCK1, PCK2, PC
9	respiratory electron transport chain	GO:022904	9.7	NDUFA1, NDUFA11, NDUFS4, NDUFS6, NDUFV1, COX7A2L
10	positive regulation of insulin-like growth factor receptor signaling pathway	GO:043568	9.3	GHRH, GH1, IGF1
11	glucose metabolic process	GO:006006	9.2	PFKM, TNF, AKR1A1, FBP1, INS, PCK1
12	response to activity	GO:014823	9.2	OXT, TNF, IL10, SCO2, BGLAP, PCK1
13	response to glucocorticoid stimulus	GO:051384	8.9	PCK2, BGLAP, IL10, TNF, OXT
14	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	8.5	GH1, CAT, F2, IGF1, INS
15	small molecule metabolic process	GO:044281	5.9	HADHA, NDUFA11, NDUFA1, PDP1, PDHX, PDHB

Molecular functions related to lactic acidosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	NADH dehydrogenase (ubiquinone) activity	GO:008137	10.2	NDUFA1, NDUFS4, NDUFS6, NDUFV1
2	pyruvate dehydrogenase (acetyl-transferring) activity	GO:004739	10.1	PDHA1, PDHA2, PDHB