MCID: LCT001
MIFTS: 48

Lactic Acidosis malady

Metabolic diseases category
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Summaries for Lactic Acidosis

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Disease Ontology:8 An acquired metabolic disease that has material basis in low ph in body tissues and blood accompanied by the buildup of lactate especially d-lactate.

MalaCards based summary: Lactic Acidosis, also known as acidosis, lactic, is related to melas syndrome and pyruvate decarboxylase deficiency. An important gene associated with Lactic Acidosis is YARS2 (tyrosyl-tRNA synthetase 2, mitochondrial), and among its related pathways are Citric acid cycle (TCA cycle) and tRNA Aminoacylation. The compounds 2-oxo acid and Lipoic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and heart.

Wikipedia:65 Lactic acidosis is a physiological condition characterized by low pH in body tissues and blood... more...

Aliases & Classifications for Lactic Acidosis

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Lactic Acidosis, Aliases & Descriptions:

Name: Lactic Acidosis 8 10
Acidosis, Lactic 62
 
Acidosis Lactic 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology8 DOID:3650
SNOMED-CT57 91273001
MeSH34 D000140

Related Diseases for Lactic Acidosis

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Diseases related to Lactic Acidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 208)
idRelated DiseaseScoreTop Affiliating Genes
1melas syndrome31.4MT-ND1, MT-ND4
2pyruvate decarboxylase deficiency31.2PDHX, DLAT
3sideroblastic anemia31.1YARS2, PUS1
4mitochondrial myopathy and sideroblastic anemia 130.9PUS1
5mitochondrial disorders30.8PUS1, MT-ND4
6pearson syndrome30.4SUCLG1, PUS1
7leigh disease30.2MT-ND4, PDHX
8encephalomyopathy11.0
9mitochondrial encephalomyopathy11.0
10myopathy11.0
11mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes10.9
12hypoglycemia10.7
13diabetes mellitus10.7
14hepatitis10.7
15leukemia10.6
16type 2 diabetes mellitus10.6
17gracile syndrome10.6
18fatal infantile lactic acidosis10.6
19cerebritis10.5
20pancreatitis10.5
21short bowel syndrome10.5
22pyruvate carboxylase deficiency disease10.5
23mitochondrial myopathy with lactic acidosis10.5
24myopathy, lactic acidosis, and sideroblastic anemia 210.5
25myopathy with deficiency of iron-sulfur cluster assembly enzyme10.5
26asthma10.4
27b-cell lymphomas10.4
28hodgkin's lymphoma10.4
29hyperphosphatemia10.4
30acute lymphoblastic leukemia10.4
31beriberi10.4
32lymphoblastic leukemia10.4
33dihydrolipoamide dehydrogenase deficiency10.4
34mitochondrial myopathy - lactic acidosis - deafness10.4
35burkitt's lymphoma10.3
36diffuse large b-cell lymphoma10.3
37hepatitis b10.3
38acute pancreatitis10.3
39hypertrophic cardiomyopathy10.3
40ischemia10.3
41neuropathy10.3
42aminoaciduria10.3
43lactic acidosis congenital infantile10.3
44succinic acidemia lactic acidosis congenital10.3
45mental retardation10.3
46hypoxia10.3
47acute liver failure10.2
48burns10.2
49cataract10.2
50malaria10.2

Graphical network of the top 20 diseases related to Lactic Acidosis:



Diseases related to lactic acidosis

Symptoms for Lactic Acidosis

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Drugs & Therapeutics for Lactic Acidosis

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Drug clinical trials:

Search ClinicalTrials for Lactic Acidosis

Search NIH Clinical Center for Lactic Acidosis

Genetic Tests for Lactic Acidosis

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Anatomical Context for Lactic Acidosis

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MalaCards organs/tissues related to Lactic Acidosis:

32
Kidney, Liver, Heart, B cells, Brain, Lung, Testes, Bone, Skeletal muscle, T cells, Bone marrow, Thyroid, Skin, Monocytes, Endothelial, Pituitary, Small intestine, Colon, Prostate, Thalamus

Animal Models for Lactic Acidosis or affiliated genes

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Publications for Lactic Acidosis

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Articles related to Lactic Acidosis:

(show top 50)    (show all 649)
idTitleAuthorsYear
1
EBV-driven HIV-associated diffuse large B-cell lymphoma causing profound lactic acidosis. (25247213)
2014
2
A patient with acute liver failure and extreme hypoglycaemia with lactic acidosis who was not in a coma: causes and consequences of lactate-protected hypoglycaemia. (24967767)
2014
3
Metformin-associated lactic acidosis requiring hospitalization. A national 10 year survey and a systematic literature review. (23436666)
2013
4
Reversible lactic acidosis in a newborn with thiamine transporter-2 deficiency. (23589815)
2013
5
Type B lactic acidosis associated with multiple myeloma. (23759296)
2013
6
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome mimicking herpes simplex encephalitis on imaging studies. (23493219)
2013
7
Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation. (21898391)
2012
8
The level of lactic acidosis affects lactate minimum in a heart rate-based lactate minimum test. (22791618)
2012
9
Central role of lactic acidosis in cancer cell resistance to glucose deprivation-induced cell death. (22190257)
2012
10
Teaching NeuroImages: mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes. (23033508)
2012
11
Lactic acidosis after resuscitation with sodium acetate. (21227457)
2012
12
Metformin and lactic acidosis. (22145266)
2011
13
Dialysis therapy for lactic acidosis caused by metformin intoxication: presentation of two cases. (21441284)
2011
14
Novel compound heterozygous mutations in the fructose-1,6-bisphosphatase gene cause hypoglycemia and lactic acidosis. (20096900)
2011
15
Severe lactic acidosis after an iatrogenic propylene glycol overdose. (20099997)
2010
16
Does metformin increase the risk of fatal or nonfatal lactic acidosis? (21121550)
2010
17
D-Lactic acidosis in calves. (17933565)
2009
18
Fatal lactic acidosis after prolonged linezolid exposure for treatment of multidrug-resistant tuberculosis. (19782904)
2009
19
Mitochondrial encephalomyopathy lactic acidosis and strokelike episodes mimicking occipital idiopathic epilepsy. (19589463)
2009
20
Mitochondrial encephalopathy, lactic acidosis, and strokelike episodes: basic concepts, clinical phenotype, and therapeutic management of MELAS syndrome. (18990125)
2008
21
Metformin and lactic acidosis in an Australian community setting: the Fremantle Diabetes Study. (18429709)
2008
22
Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis. (18782901)
2008
23
Heeding clues to metformin-associated lactic acidosis: prompt response can save life. (18660415)
2008
24
Is there a role for sodium bicarbonate in treating lactic acidosis from shock? (18614899)
2008
25
Fanconi syndrome and lactic acidosis associated with stavudine and lamivudine therapy. (18580619)
2008
26
A high incidence of lactic acidosis and symptomatic hyperlactatemia in women receiving highly active antiretroviral therapy in Soweto, South Africa. (17578788)
2007
27
Severe lactic acidosis treated with prolonged hemodialysis: recovery after massive overdoses of metformin. (16423187)
2006
28
Recurrent D-lactic acidosis in a child with short bowel syndrome. (15927940)
2005
29
D(-)-lactic acid-producing probiotics, D(-)-lactic acidosis and infants. (15565207)
2004
30
Link between metformin and lactic acidosis? (15606058)
2004
31
Treatment of HAART-induced lactic acidosis with B vitamin supplements. (16215128)
2004
32
Fulminant post-transplant lymphoproliferative disorder presenting with lactic acidosis and acute liver failure. (15199200)
2004
33
Anaesthesia for an adolescent with mitochondrial encephalomyopathy-lactic acidosis-stroke-like episodes syndrome. (12791122)
2003
34
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. (12804446)
2003
35
Fatal lactic acidosis and mimicking Guillain-BarrAc syndrome in an adolescent with human immunodeficiency virus infection. (12886900)
2003
36
Miller Fisher variant of Guillain-BarrAc syndrome associated with lactic acidosis and stavudine therapy. (12746793)
2003
37
Simvastatin-induced lactic acidosis: a rare adverse reaction? (12386648)
2002
38
An autopsy case of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome with chronic renal failure. (11506313)
2001
39
Ketoacidosis accompanied by epileptic seizures in a patient with diabetes mellitus and mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). (11119021)
2000
40
Increased prevalence of vitiligo, but no evidence of premature ageing, in the skin of patients with bp 3243 mutation in mitochondrial DNA in the mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome (MELAS). (10233312)
1999
41
Familial occurrence of intestinal obstruction in children with the syndrome of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). (9869067)
1998
42
Diagnosis of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes in a Chinese family by PCR/restriction enzyme analysis. (16696023)
1995
43
Transient tyrosinemia presenting as lactic acidosis in a term baby: report of one case. (7618475)
1995
44
Pancreatic beta-cell secretory defect associated with mitochondrial point mutation of the tRNA(LEU(UUR)) gene: a study in seven families with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS). (7988784)
1994
45
Proton magnetic resonance spectroscopy studies in lactic acidosis and mitochondrial disorders. (8412023)
1993
46
HMPAO-SPECT imaging resembling Alzheimer-type dementia in mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS). (2213201)
1990
47
Lactic acidosis increases tumor necrosis factor secretion and transcription in vitro. (2214745)
1990
48
Increased accumulation of N-isopropyl-p-(123I)-iodoamphetamine in two cases with mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS). (2636890)
1989
49
Partial pyruvate decarboxylase deficiency with profound lactic acidosis and hyperammonemia: responses to dichloroacetate and benzoate. (4050860)
1985
50
Urinary organic acids in a case of congenital lactic acidosis due to pyruvate decarboxylase deficiency. (117229)
1978

Variations for Lactic Acidosis

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Expression for genes affiliated with Lactic Acidosis

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Expression patterns in normal tissues for genes affiliated with Lactic Acidosis

Search GEO for disease gene expression data for Lactic Acidosis.

Pathways for genes affiliated with Lactic Acidosis

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Compounds for genes affiliated with Lactic Acidosis

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR
See all sources

Compounds related to Lactic Acidosis according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
12-oxo acid4410.0DLAT, PDHX
2Lipoic acid24 1111.0DLAT, PDHX
3dihydrolipoamide44 2411.0PDHX, DLAT
4alpha lipoic acid449.9DLAT, PDHX
5Coenzyme A24 1110.8DLAT, SUCLG1
6Ubiquinol 8249.7MT-ND1, MT-ND4
7trna449.7PUS1, TUFM
8Sulfide249.6MT-ND1, MT-ND4
9QH2249.6MT-ND4, MT-ND1
10Ubiquinone Q2249.5MT-ND1, MT-ND4
11alpha-ketoglutarate449.5DLAT, PDHX
12Ubiquinone Q1249.4MT-ND1, MT-ND4
13nad28 2410.3DLAT, MT-ND1, MT-ND4
14nadh44 24 1111.3MT-ND4, MT-ND1, DLAT
15pyruvate449.1DLAT, PDHX, MT-ND1, MT-ND4

GO Terms for genes affiliated with Lactic Acidosis

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Cellular components related to Lactic Acidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial matrixGO:0057598.8DLAT, PDHX, YARS2, SUCLG1
2mitochondrionGO:0057398.5DLAT, YARS2, SUCLG1, PUS1, TUFM

Biological processes related to Lactic Acidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tricarboxylic acid cycleGO:0060999.8DLAT, SUCLG1
2regulation of acetyl-CoA biosynthetic process from pyruvateGO:0105109.7DLAT, PDHX
3pyruvate metabolic processGO:0060909.5DLAT, PDHX
4cellular metabolic processGO:0442379.4DLAT, PDHX, SUCLG1

Molecular functions related to Lactic Acidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1poly(A) RNA bindingGO:0448228.9YARS2, SUCLG1, PUS1, TUFM

Products for genes affiliated with Lactic Acidosis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Lactic Acidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet