MCID: LCT001
MIFTS: 51

Lactic Acidosis malady

Categories: Metabolic diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Lactic Acidosis

Aliases & Descriptions for Lactic Acidosis:

Name: Lactic Acidosis 12 29 14
Acidosis, Lactic 42 69
Acidosis Lactic 52

Classifications:



External Ids:

Disease Ontology 12 DOID:3650
ICD10 33 E87.2
MeSH 42 D000140
NCIt 47 C98969
SNOMED-CT 64 91273001
UMLS 69 C0001125

Summaries for Lactic Acidosis

Disease Ontology : 12 An acquired metabolic disease that has material basis in low pH in body tissues and blood accompanied by the buildup of lactate especially D-lactate.

MalaCards based summary : Lactic Acidosis, also known as acidosis, lactic, is related to myoclonic epilepsy associated with ragged-red fibers and mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. An important gene associated with Lactic Acidosis is YARS2 (Tyrosyl-TRNA Synthetase 2), and among its related pathways/superpathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Epinephrine and Celecoxib have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and heart.

Wikipedia : 71 Lactic acidosis is a medical condition characterized by the buildup of lactate (especially L-lactate) in... more...

Related Diseases for Lactic Acidosis

Diseases in the Lactic Acidosis family:

Lactic Acidosis Congenital Infantile Fatal Infantile Lactic Acidosis

Diseases related to Lactic Acidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 252)
id Related Disease Score Top Affiliating Genes
1 myoclonic epilepsy associated with ragged-red fibers 28.7 LARS2 MT-ATP6 MT-CO3 MT-ND1 MT-ND4 MT-ND5
2 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 12.5
3 mitochondrial myopathy with lactic acidosis 12.4
4 myopathy, lactic acidosis, and sideroblastic anemia 2 12.4
5 myopathy with lactic acidosis, hereditary 12.3
6 hydrops, lactic acidosis, and sideroblastic anemia 12.3
7 myopathy, lactic acidosis, and sideroblastic anemia 3 12.2
8 myopathy, lactic acidosis, and sideroblastic anemia 12.1
9 fatal infantile lactic acidosis 12.1
10 lactic acidosis congenital infantile 11.9
11 succinic acidemia lactic acidosis congenital 11.9
12 infantile myopathy and lactic acidosis 11.9
13 gracile syndrome 11.8
14 mitochondrial myopathy and sideroblastic anemia 1 11.8
15 dihydrolipoamide dehydrogenase deficiency 11.8
16 pyruvate dehydrogenase e1-alpha deficiency 11.8
17 mitochondrial dna depletion syndrome 9 11.7
18 pyruvate carboxylase deficiency 11.7
19 pyruvate dehydrogenase lipoic acid synthetase deficiency 11.6
20 combined oxidative phosphorylation deficiency 10 11.6
21 combined oxidative phosphorylation deficiency 18 11.6
22 combined oxidative phosphorylation deficiency 19 11.5
23 mitochondrial phosphate carrier deficiency 11.5
24 mitochondrial disorders 11.2
25 mitochondrial complex i deficiency 11.2
26 pyruvate dehydrogenase phosphatase deficiency 11.2
27 metabolic acidosis 11.2
28 combined oxidative phosphorylation deficiency 2 11.1
29 combined oxidative phosphorylation deficiency 3 11.1
30 multiple mitochondrial dysfunctions syndrome 1 11.0
31 pyruvate dehydrogenase e1-beta deficiency 11.0
32 combined oxidative phosphorylation deficiency 14 11.0
33 mitochondrial dna depletion syndrome 13 11.0
34 combined oxidative phosphorylation deficiency 11 11.0
35 sengers syndrome 11.0
36 mitochondrial dna depletion syndrome 8a 11.0
37 mitochondrial complex iii deficiency, nuclear type 6 11.0
38 combined oxidative phosphorylation deficiency 17 11.0
39 combined oxidative phosphorylation deficiency 23 11.0
40 barth syndrome 11.0
41 maple syrup urine disease, type ii 10.9
42 leigh syndrome, french-canadian type 10.9
43 myopathy with deficiency of iron-sulfur cluster assembly enzyme 10.9
44 multiple mitochondrial dysfunctions syndrome 3 10.8
45 cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 4 10.8
46 mitochondrial complex iv deficiency 10.8
47 multiple mitochondrial dysfunctions syndrome 2 10.8
48 lipoyltransferase 1 deficiency 10.8
49 mitochondrial complex iii deficiency, nuclear type 1 10.8
50 leigh syndrome 10.8

Graphical network of the top 20 diseases related to Lactic Acidosis:



Diseases related to Lactic Acidosis

Symptoms & Phenotypes for Lactic Acidosis

Drugs & Therapeutics for Lactic Acidosis

Drugs for Lactic Acidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 114)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
3
Metformin Approved Phase 4,Phase 3,Phase 2 657-24-9 14219 4091
4
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
5
Telbivudine Approved, Investigational Phase 4 3424-98-4 159269
6 Parecoxib Approved Phase 4 198470-84-7
7
Adefovir Dipivoxil Approved, Investigational Phase 4 142340-99-6 60871
8
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
9
Stavudine Approved, Investigational Phase 4,Phase 2,Phase 3 3056-17-5 18283
10
Fenoldopam Approved Phase 4 67227-56-9, 67227-57-0 3341
11
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
12
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
13
Thiamine Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 59-43-8 1130
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 59-30-3 6037
15
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 83-88-5 493570
16 Adefovir Phase 4
17 insulin Phase 4,Phase 2
18 Analgesics Phase 4
19 Narcotics Phase 4
20 Neurotransmitter Agents Phase 4
21 Cyclooxygenase 2 Inhibitors Phase 4
22 Cyclooxygenase Inhibitors Phase 4
23 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 3
24 Analgesics, Non-Narcotic Phase 4
25 Trace Elements Phase 4,Phase 2,Phase 3,Phase 1
26 Analgesics, Opioid Phase 4
27 Tranquilizing Agents Phase 4
28 Peripheral Nervous System Agents Phase 4
29 Vasodilator Agents Phase 4
30 Vitamin B Complex Phase 4,Phase 2,Phase 3,Phase 1
31 Epinephryl borate Phase 4
32 Hypoglycemic Agents Phase 4,Phase 3,Phase 2
33 Vitamins Phase 4,Phase 2,Phase 3,Phase 1
34 Anti-Infective Agents Phase 4,Phase 2,Phase 3
35 Insulin, Globin Zinc Phase 4,Phase 2
36 Anti-Inflammatory Agents Phase 4
37 Psychotropic Drugs Phase 4
38 Antihypertensive Agents Phase 4
39 Anti-Inflammatory Agents, Non-Steroidal Phase 4
40 Racepinephrine Phase 4
41 Liver Extracts Phase 4
42 Anti-Retroviral Agents Phase 4,Phase 2,Phase 3
43 Reverse Transcriptase Inhibitors Phase 4,Phase 2,Phase 3
44 Antipsychotic Agents Phase 4
45 Micronutrients Phase 4,Phase 2,Phase 3,Phase 1
46 Antirheumatic Agents Phase 4
47 Antiviral Agents Phase 4,Phase 2,Phase 3
48 Central Nervous System Depressants Phase 4
49 Dopamine agonists Phase 4
50 Dermatologic Agents Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 65)
id Name Status NCT ID Phase
1 Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery Unknown status NCT01524315 Phase 4
2 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4
3 Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery Unknown status NCT01930318 Phase 4
4 Telbivudine Renoprotective Effect in Patients With the HBV-related Liver Cirrhosis: a Randomized Controlled Trial Unknown status NCT01799486 Phase 4
5 Sodium Bicarbonate in Cardiopulmonary Resuscitation Unknown status NCT01377337 Phase 4
6 Lactate Metabolism Study in HIV Infected Persons Completed NCT00202228 Phase 4
7 Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass Completed NCT00747331 Phase 4
8 Type 2 Diabetes and Ambulatory Surgery Patients Completed NCT03179254 Phase 4
9 Responses to Influenza Vaccine in Patients With Mitochondrial Disorders (MELAS) Completed NCT01831934 Phase 4
10 The Metformin in Coronary Artery Bypass Graft (CABG) (MetCAB) Trial Completed NCT01438723 Phase 4
11 Body Weight Effects on Glucophage's Efficacy in Chinese Diagnosed T2DM Patients Completed NCT00778622 Phase 4
12 Lactic Acidosis During Entecavir(ETV)Treatment Terminated NCT01354652 Phase 4
13 Dichloroacetate Treatment of Congenital Lactic Acidosis Phase B: Open Label Completed NCT01797276 Phase 3
14 Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis Completed NCT00004490 Phase 3
15 D4T or Abacavir Plus Vitamin Enhancement in HIV-Infected Patients (DAVE) Completed NCT00143702 Phase 2, Phase 3
16 RBC Transfusion in Severe Anemia With Lactic Acidosis Completed NCT01586923 Phase 3
17 Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency: Not yet recruiting NCT02616484 Phase 3
18 Patients With Heart Failure ANd Type 2 Diabetes Treated With Placebo Or Metformin (PHANTOM) Pilot Study Terminated NCT00325910 Phase 3
19 Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome Unknown status NCT00068913 Phase 2
20 Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock Patients Completed NCT01262196 Phase 2
21 Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients Completed NCT01004198 Phase 2
22 Study of Idebenone in the Treatment of Mitochondrial Encephalopathy Lactic Acidosis & Stroke-like Episodes Completed NCT00887562 Phase 2
23 Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia Completed NCT00004493 Phase 2
24 SELESTIAL: Trial of Insulin to Control Blood Sugar After Acute Stroke Using Magnetic Resonance Imaging (MRI) End-Points Completed NCT00124826 Phase 2
25 Thiamine as a Metabolic Resuscitator in Septic Shock Completed NCT01070810 Phase 1, Phase 2
26 The KHENERGY Study Recruiting NCT02909400 Phase 2
27 Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest Not yet recruiting NCT02974257 Phase 2
28 The Effects of Neoadjuvant Metformin on Tumour Cell Proliferation and Tumour Progression in Pancreatic Ductal Adenocarcinoma Not yet recruiting NCT02978547 Phase 2
29 Metformin in Moderate and Severe Renal Failure (CKD 3-4): A Follow-up Study Not yet recruiting NCT02848508 Phase 2
30 Phase 2c Dose Comparison Study of MP4OX in Trauma Withdrawn NCT01973504 Phase 2
31 A Dose-escalating Clinical Trial With KH176 Completed NCT02544217 Phase 1
32 A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours Completed NCT00566410 Phase 1
33 Anaplerotic Therapy in Propionic Acidemia Completed NCT00645879 Phase 1
34 Thiamine Supplementation in Patients With Septic Shock Recruiting NCT03122678 Phase 1
35 Nitroglycerin Infusion During Cardiac Surgery Unknown status NCT01901419
36 Use of Phenoxybenzamine [PBZ] IV to Assist High Flow Low Pressure Perfusion [HFLPP] on Cardio-Pulmonary Bypass Unknown status NCT00620945
37 Mitochondrial nt3243 A>G Mutation in Taiwan Unknown status NCT02114554
38 Psychophysical Aspects of Maximal Anaerobic Performance Unknown status NCT01770288
39 Effect of Blood Storage Age on the Resolution of Lactic Acidosis in Children With Severe Malarial Anemia at Mulago Hospital Completed NCT01580111
40 Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media Completed NCT01873859
41 Study On the Role of Mitochondrial Dysfunction in the Pathogenesis of Metformin-associated Lactic Acidosis Completed NCT00942123
42 Metformin Treatment, Renal Function and Lactic Acidosis Completed NCT01358994
43 Lactic Acidosis During and After Seizures Completed NCT01833247
44 Prevention of Dichloroacetate Toxicity Completed NCT00031161
45 Dichloroacetate Kinetics, Metabolism and Toxicology Completed NCT00015015
46 Pharmacotoxicology of Trichloroethylene Metabolites Completed NCT00874276
47 Study of Blood Lactate Levels in Patients Treated With Antipsychotics Completed NCT01139463
48 Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia Completed NCT00004353
49 Variation in Serum Levels of Metformin in Patients With Reduced Renal Function Completed NCT00767351
50 The Cytoadherence in Pediatric Malaria (CPM) Study Completed NCT00707200

Search NIH Clinical Center for Lactic Acidosis

Cochrane evidence based reviews: acidosis, lactic

Genetic Tests for Lactic Acidosis

Genetic tests related to Lactic Acidosis:

id Genetic test Affiliating Genes
1 Lactic Acidosis 29

Anatomical Context for Lactic Acidosis

MalaCards organs/tissues related to Lactic Acidosis:

39
Kidney, Liver, Heart, B Cells, Testes, Brain, Lung

Publications for Lactic Acidosis

Articles related to Lactic Acidosis:

(show top 50) (show all 760)
id Title Authors Year
1
Lactic acidosis as an infrequent manifestation of a pheocromocytoma. ( 27894603 )
2017
2
D-lactic acidosis - case report and review of theA literature. ( 27723911 )
2017
3
Prediction of long-term prognosis by heteroplasmy levels of the m.3243A>G mutation in patients with the mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome. ( 27869334 )
2017
4
Probiotics, D-Lactic Acidosis, Oxidative Stress and Strain Specificity. ( 28080206 )
2017
5
Adult-onset Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke (MELAS)-like Encephalopathy Diagnosed Based on the Complete Sequencing of Mitochondrial DNA Extracted from Biopsied Muscle without any Myopathic Changes. ( 28050007 )
2017
6
Reversal of refractory severe lactic acidosis by thiamine replacement. ( 27751597 )
2016
7
Mendeliome sequencing enables differential diagnosis and treatment of neonatal lactic acidosis. ( 27317552 )
2016
8
Epilepsy Characteristics and Clinical Outcome in Patients With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes (MELAS). ( 27671241 )
2016
9
Early Onset of Diabetes Mellitus Accelerates Cognitive Decline in Japanese Patients with Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes. ( 27063563 )
2016
10
Prognosis of alcohol-associated lactic acidosis in critically ill patients: an 8-year study. ( 27748410 )
2016
11
Viekira Pak Induced Fatal Lactic Acidosis: A Case Report of an Unusual Side Effect. ( 28044114 )
2016
12
Expanding the clinical spectrum of myopathy, encephalopathy, lactic acidosis, and stroke-like (MELAS) episode: A case with A3243G mitochondrial DNA mutation presenting as MELAS and congenital melanocytic naevi overlap. ( 26954819 )
2016
13
Metformin associated lactic acidosis (MALA): clinical profiling and management. ( 26800971 )
2016
14
Lactic acidosis: an update. ( 27522622 )
2016
15
Epinephrine-induced lactic acidosis in orthognathic surgery: a report of two cases. ( 27847739 )
2016
16
D-lactic acidosis: A rare cause of metabolic acidosis. ( 27265832 )
2016
17
I^ Agonist-induced lactic acidosis, an evidence-based approach to a critical question. ( 26830219 )
2016
18
Non-occlusive Mesenteric Ischemia with Diabetic Ketoacidosis and Lactic Acidosis Following the Administration of a Sodium Glucose Co-transporter 2 Inhibitor. ( 27374678 )
2016
19
Ombitasvir-Paritaprevir-Ritonavir-Dasabuvir (Viekira Pak)-Induced Lactic Acidosis. ( 27661862 )
2016
20
Venlafaxine intoxication in an adolescent presenting with severe lactic acidosis. ( 27976562 )
2016
21
A Rare Case of Persistent Lactic Acidosis in the ICU: Glycogenic Hepatopathy and Mauriac Syndrome. ( 27699071 )
2016
22
Migratory stroke-like lesions in a case of adult-onset mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome and a review of imaging findings. ( 27920873 )
2016
23
Lactic acidosis and the relationship with metformin usage: Case reports. ( 27861334 )
2016
24
Sigmoid volvulus in a patient with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS): a rare occurrence. ( 26935953 )
2016
25
Metformin-related lactic acidosis: is it a myth or an underestimated reality? ( 27686366 )
2016
26
Metformin use and risk of lactic acidosis in people with diabetes with and without renal impairment: a cohort study in Denmark and the UK. ( 27504911 )
2016
27
A novel mutation in NDUFB11 unveils a new clinical phenotype associated with lactic acidosis and sideroblastic anemia. ( 27102574 )
2016
28
A Fatal Case of Metformin-associated Lactic Acidosis. ( 27041163 )
2016
29
Metformin-Associated Lactic Acidosis in a Patient with Normal Renal Function. ( 27197687 )
2016
30
COXPD9 an Evolving Multisystem Disease; Congenital Lactic Acidosis, Sensorineural Hearing Loss, Hypertrophic Cardiomyopathy, Cirrhosis and Interstitial Nephritis. ( 27815843 )
2016
31
Lactic acidosis switches cancer cells from aerobic glycolysis back to dominant oxidative phosphorylation. ( 27259254 )
2016
32
Peritoneal dialysis treatment of metformin-associated lactic acidosis in a diabetic nephropathy patienta8c. ( 27509590 )
2016
33
Draft Genome Sequence of Lactobacillus delbrueckii Strain #22 Isolated from a Patient with Short Bowel Syndrome and Previous d-Lactic Acidosis and Encephalopathy. ( 27469967 )
2016
34
Rapid quantification of metabolic intermediates in blood by liquid chromatography-tandem mass spectrometry to investigate congenital lactic acidosis. ( 27720121 )
2016
35
ECHS1 Deficiency as a Cause of Severe Neonatal Lactic Acidosis. ( 26920905 )
2016
36
Extracorporeal treatment with high-volume continuous venovenous hemodiafiltration and charcoal-based sorbent hemoperfusion for severe metformin-associated lactic acidosis. ( 27275079 )
2016
37
Recoverable, Record-High Lactic Acidosis in a Patient with Glycogen Storage Disease Type 1: A Mixed Type A and Type B Lactate Disorder. ( 27974893 )
2016
38
Trimethoprim/Sulfamethoxazole-Induced Severe Lactic Acidosis: A Case Report and Review of the Literature. ( 27124045 )
2016
39
Recommendations for the Management of Strokelike Episodes in Patients With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Strokelike Episodes. ( 26954033 )
2016
40
Lactic acidosis: relationship between metformin levels, lactate concentration and mortality. ( 26882092 )
2016
41
Lactic Acidosis in Diabetic Population: Is Metformin Implicated? Results of a Matched Case-Control Study Performed on the Type 2 Diabetes Population of Grenoble Hospital University. ( 27034959 )
2016
42
Differential diagnosis of mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) and ischemic stroke using 3D pseudocontinuous arterial spin labeling. ( 27348222 )
2016
43
Metformin associated lactic acidosis in Auckland City Hospital 2005 to 2009. ( 27458565 )
2016
44
An unusual case of cardiogenic shock in which thiamine administration led to reversal of lactic acidosis and heart function recovery: Shoshin beriberi in an adolescent. ( 27505323 )
2016
45
Audiological manifestations in mitochondrial encephalomyopathy lactic acidosis and stroke like episodes (MELAS) syndrome. ( 27359089 )
2016
46
Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes (MELAS): A Case Report and Critical Reappraisal of Treatment Options. ( 26797286 )
2016
47
Can an early diagnostic procedure of metformin-associated lactic acidosis in an emergency unit reduce mortality? ( 27425264 )
2016
48
Lactic acidosis due to attempted suicide with metformin overdose: A case report. ( 27052159 )
2016
49
Dandy-Walker Malformation and Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episode Syndrome: Is There a Causal or Coincidental Association? ( 26905003 )
2016
50
Corrigendum to "Metformin-associated lactic acidosis: Current perspectives on causes and risk" [Metabolism 65 (2016) 20-29]. ( 27311500 )
2016

Variations for Lactic Acidosis

Expression for Lactic Acidosis

Search GEO for disease gene expression data for Lactic Acidosis.

Pathways for Lactic Acidosis

Pathways related to Lactic Acidosis according to GeneCards Suite gene sharing:

(show all 12)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 COX14 DLD ISCU MT-ATP6 MT-CO3 MT-ND1
2
Show member pathways
12.89 COX14 DLD MT-ATP6 MT-CO3 MT-ND1 MT-ND4
3
Show member pathways
12.38 DLD PC PDHA1 PDHX
4
Show member pathways
12.1 DLD PC PDHA1 SUCLG1
5
Show member pathways
11.98 LARS2 MT-TK MT-TL1 YARS2
6
Show member pathways
11.67 DLD PDHA1 PDHX PDP1 SUCLG1
7
Show member pathways
11.64 DLD PC PDHA1 SUCLG1
8
Show member pathways
11.45 DLD PDHA1 PDHX
9
Show member pathways
11.2 DLD PC PDHA1
10
Show member pathways
11.16 DLD PDHA1 PDHX
11 11.06 DLD LARS2 PC PDHA1 PDHX SUCLG1
12 11.02 DLD SUCLG1

GO Terms for Lactic Acidosis

Cellular components related to Lactic Acidosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.73 MT-ATP6 MT-CO3 MT-ND1 MT-ND4 MT-ND5 SUCLG1
2 mitochondrial matrix GO:0005759 9.65 DLD ISCU LARS2 PC PDHA1 PDHX
3 mitochondrial membrane GO:0031966 9.58 COX14 MT-ND1 MT-ND4
4 mitochondrion GO:0005739 9.55 COX14 DLD ISCU LARS2 MT-CO3 MT-ND1
5 respiratory chain GO:0070469 9.54 MT-ND1 MT-ND4 MT-ND5
6 mitochondrial respiratory chain complex I GO:0005747 9.5 MT-ND1 MT-ND4 MT-ND5
7 pyruvate dehydrogenase complex GO:0045254 9.33 DLD PDHA1 PDHX

Biological processes related to Lactic Acidosis according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.92 DLD MT-ND1 MT-ND4 MT-ND5 PDHA1
2 aging GO:0007568 9.78 DLD MT-ATP6 MT-ND4 POLG
3 mitochondrial respiratory chain complex I assembly GO:0032981 9.67 MT-ND1 MT-ND4 MT-ND5
4 tricarboxylic acid cycle GO:0006099 9.58 DLD PDHA1 SUCLG1
5 mitochondrial electron transport, NADH to ubiquinone GO:0006120 9.56 DLD MT-ND1 MT-ND4 MT-ND5
6 glyoxylate metabolic process GO:0046487 9.54 DLD PDHA1 PDHX
7 response to hyperoxia GO:0055093 9.51 MT-ATP6 POLG
8 cellular nitrogen compound metabolic process GO:0034641 9.5 DLD PDHA1 PDHX
9 ATP synthesis coupled electron transport GO:0042773 9.46 MT-ND4 MT-ND5
10 acetyl-CoA biosynthetic process from pyruvate GO:0006086 9.43 DLD PDHA1
11 mitochondrial acetyl-CoA biosynthetic process from pyruvate GO:0061732 9.33 DLD PDHA1 PDHX
12 pyruvate metabolic process GO:0006090 9.26 DLD PC PDHA1 PDHX
13 regulation of acetyl-CoA biosynthetic process from pyruvate GO:0010510 8.92 DLD PDHA1 PDHX PDP1

Molecular functions related to Lactic Acidosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.65 DLD MT-ND1 MT-ND4 MT-ND5 PDHA1
2 ligase activity GO:0016874 9.46 LARS2 PC SUCLG1 YARS2
3 NADH dehydrogenase (ubiquinone) activity GO:0008137 9.13 MT-ND1 MT-ND4 MT-ND5
4 pyruvate dehydrogenase (NAD+) activity GO:0034604 8.8 DLD PDHA1 PDHX

Sources for Lactic Acidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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