MCID: LCT001
MIFTS: 46

Lactic Acidosis malady

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Summaries for Lactic Acidosis

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 An acquired metabolic disease that has material basis in low ph in body tissues and blood accompanied by the buildup of lactate especially d-lactate.

MalaCards: Lactic Acidosis, also known as acidosis, lactic, is related to melas syndrome and sideroblastic anemia. An important gene associated with Lactic Acidosis is YARS2 (tyrosyl-tRNA synthetase 2, mitochondrial), and among its related pathways are Citric acid cycle (TCA cycle) and tRNA Aminoacylation. The compounds 2-oxo acid and Lipoic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and heart.

Wikipedia:65 Lactic acidosis is a physiological condition characterized by low pH in body tissues and blood... more...

Aliases & Classifications for Lactic Acidosis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT
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Aliases & Descriptions:

lactic acidosis 8 10
acidosis, lactic 62
acidosis lactic 45


External Ids:

Disease Ontology8 DOID:3650
SNOMED-CT58 91273001
MeSH35 D000140

Related Diseases for Lactic Acidosis

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17GeneCards, 18GeneDecks
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Diseases related to Lactic Acidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 197)
idRelated DiseaseScoreTop Affiliating Genes
1melas syndrome31.2MT-ND1, MT-ND4
2sideroblastic anemia30.8YARS2, PUS1
3pyruvate decarboxylase deficiency30.8PDHX, DLAT
4mitochondrial disorders30.7PUS1, MT-ND4
5mitochondrial myopathy and sideroblastic anemia 130.5PUS1
6pearson syndrome30.2SUCLG1, PUS1
7leigh disease30.1MT-ND4, PDHX
8myopathy11.0
9encephalomyopathy10.9
10mitochondrial encephalomyopathy10.9
11mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes10.9
12hypoglycemia10.7
13diabetes mellitus10.7
14hepatitis10.6
15leukemia10.6
16type 2 diabetes mellitus10.6
17cerebritis10.5
18pancreatitis10.5
19gracile syndrome10.5
20fatal infantile lactic acidosis10.5
21myopathy, lactic acidosis, and sideroblastic anemia 210.5
22short bowel syndrome10.5
23hyperphosphatemia10.4
24asthma10.4
25hodgkin's lymphoma10.4
26mitochondrial myopathy with lactic acidosis10.4
27myopathy with deficiency of iron-sulfur cluster assembly enzyme10.4
28beriberi10.4
29pyruvate carboxylase deficiency disease10.4
30lymphoblastic leukemia10.4
31mitochondrial myopathy - lactic acidosis - deafness10.4
32acute pancreatitis10.3
33hepatitis b10.3
34burkitt's lymphoma10.3
35hypertrophic cardiomyopathy10.3
36ischemia10.3
37neuropathy10.3
38aminoaciduria10.3
39b-cell lymphomas10.3
40lactic acidosis congenital infantile10.3
41succinic acidemia lactic acidosis congenital10.3
42mental retardation10.3
43hypoxia10.3
44burns10.2
45hepatitis c10.2
46diabetic ketoacidosis10.2
47status asthmaticus10.2
48pancytopenia10.2
49metabolic acidosis10.2
50cataract10.2

Graphical network of the top 20 diseases related to Lactic Acidosis:



Diseases related to lactic acidosis

Symptoms for Lactic Acidosis

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Drugs & Therapeutics for Lactic Acidosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Lactic Acidosis

Search NIH Clinical Center for Lactic Acidosis

Genetic Tests for Lactic Acidosis

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Anatomical Context for Lactic Acidosis

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33MalaCards
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MalaCards organs/tissues related to Lactic Acidosis:

33
Kidney, Liver, Heart, Testes, B cells, Brain, Lung, Skeletal muscle, Bone, Endothelial, T cells, Monocytes, Bone marrow, Skin, Thyroid, Pituitary, Prostate, Colon, Small intestine, Thalamus

Animal Models for Lactic Acidosis or affiliated genes

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Publications for Lactic Acidosis

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52PubMed
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Articles related to Lactic Acidosis:

(show top 50)    (show all 620)
idTitleAuthorsYear
1
Metformin-associated lactic acidosis requiring hospitalization. A national 10 year survey and a systematic literature review. (23436666)
2013
2
Reversible lactic acidosis in a newborn with thiamine transporter-2 deficiency. (23589815)
2013
3
Type B lactic acidosis associated with multiple myeloma. (23759296)
2013
4
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome mimicking herpes simplex encephalitis on imaging studies. (23493219)
2013
5
Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation. (21898391)
2012
6
The level of lactic acidosis affects lactate minimum in a heart rate-based lactate minimum test. (22791618)
2012
7
Central role of lactic acidosis in cancer cell resistance to glucose deprivation-induced cell death. (22190257)
2012
8
Teaching NeuroImages: mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes. (23033508)
2012
9
Lactic acidosis after resuscitation with sodium acetate. (21227457)
2012
10
Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs. (22568883)
2012
11
Metformin and lactic acidosis. (22145266)
2011
12
Dialysis therapy for lactic acidosis caused by metformin intoxication: presentation of two cases. (21441284)
2011
13
Novel compound heterozygous mutations in the fructose-1,6-bisphosphatase gene cause hypoglycemia and lactic acidosis. (20096900)
2011
14
Severe lactic acidosis after an iatrogenic propylene glycol overdose. (20099997)
2010
15
Does metformin increase the risk of fatal or nonfatal lactic acidosis? (21121550)
2010
16
D-Lactic acidosis in calves. (17933565)
2009
17
Fatal lactic acidosis after prolonged linezolid exposure for treatment of multidrug-resistant tuberculosis. (19782904)
2009
18
Mitochondrial encephalomyopathy lactic acidosis and strokelike episodes mimicking occipital idiopathic epilepsy. (19589463)
2009
19
Mitochondrial encephalopathy, lactic acidosis, and strokelike episodes: basic concepts, clinical phenotype, and therapeutic management of MELAS syndrome. (18990125)
2008
20
Metformin and lactic acidosis in an Australian community setting: the Fremantle Diabetes Study. (18429709)
2008
21
Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis. (18782901)
2008
22
Heeding clues to metformin-associated lactic acidosis: prompt response can save life. (18660415)
2008
23
Is there a role for sodium bicarbonate in treating lactic acidosis from shock? (18614899)
2008
24
Fanconi syndrome and lactic acidosis associated with stavudine and lamivudine therapy. (18580619)
2008
25
A high incidence of lactic acidosis and symptomatic hyperlactatemia in women receiving highly active antiretroviral therapy in Soweto, South Africa. (17578788)
2007
26
Severe lactic acidosis treated with prolonged hemodialysis: recovery after massive overdoses of metformin. (16423187)
2006
27
Point of care testing for antiretroviral therapy-related lactic acidosis in resource-poor settings. (16514312)
2006
28
Evolution of brain imaging abnormalities in mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes. (17204916)
2006
29
Recurrent D-lactic acidosis in a child with short bowel syndrome. (15927940)
2005
30
D(-)-lactic acid-producing probiotics, D(-)-lactic acidosis and infants. (15565207)
2004
31
Link between metformin and lactic acidosis? (15606058)
2004
32
Treatment of HAART-induced lactic acidosis with B vitamin supplements. (16215128)
2004
33
Fulminant post-transplant lymphoproliferative disorder presenting with lactic acidosis and acute liver failure. (15199200)
2004
34
Anaesthesia for an adolescent with mitochondrial encephalomyopathy-lactic acidosis-stroke-like episodes syndrome. (12791122)
2003
35
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. (12804446)
2003
36
Fatal lactic acidosis and mimicking Guillain-BarrAc syndrome in an adolescent with human immunodeficiency virus infection. (12886900)
2003
37
Miller Fisher variant of Guillain-BarrAc syndrome associated with lactic acidosis and stavudine therapy. (12746793)
2003
38
Simvastatin-induced lactic acidosis: a rare adverse reaction? (12386648)
2002
39
An autopsy case of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome with chronic renal failure. (11506313)
2001
40
Ketoacidosis accompanied by epileptic seizures in a patient with diabetes mellitus and mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). (11119021)
2000
41
Increased prevalence of vitiligo, but no evidence of premature ageing, in the skin of patients with bp 3243 mutation in mitochondrial DNA in the mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome (MELAS). (10233312)
1999
42
Familial occurrence of intestinal obstruction in children with the syndrome of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). (9869067)
1998
43
Diagnosis of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes in a Chinese family by PCR/restriction enzyme analysis. (16696023)
1995
44
Transient tyrosinemia presenting as lactic acidosis in a term baby: report of one case. (7618475)
1995
45
Pancreatic beta-cell secretory defect associated with mitochondrial point mutation of the tRNA(LEU(UUR)) gene: a study in seven families with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS). (7988784)
1994
46
Proton magnetic resonance spectroscopy studies in lactic acidosis and mitochondrial disorders. (8412023)
1993
47
HMPAO-SPECT imaging resembling Alzheimer-type dementia in mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS). (2213201)
1990
48
Lactic acidosis increases tumor necrosis factor secretion and transcription in vitro. (2214745)
1990
49
Partial pyruvate decarboxylase deficiency with profound lactic acidosis and hyperammonemia: responses to dichloroacetate and benzoate. (4050860)
1985
50
Urinary organic acids in a case of congenital lactic acidosis due to pyruvate decarboxylase deficiency. (117229)
1978

Variations for Lactic Acidosis

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Expression for genes affiliated with Lactic Acidosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lactic Acidosis

Search GEO for disease gene expression data for Lactic Acidosis.

Pathways for genes affiliated with Lactic Acidosis

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50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Lactic Acidosis

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45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR
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Compounds related to Lactic Acidosis according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
12-oxo acid4510.0DLAT, PDHX
2Lipoic acid24 1111.0DLAT, PDHX
3dihydrolipoamide45 2411.0PDHX, DLAT
4alpha lipoic acid459.9DLAT, PDHX
5Coenzyme A24 1110.8DLAT, SUCLG1
6Ubiquinol 8249.7MT-ND1, MT-ND4
7trna459.7PUS1, TUFM
8Sulfide249.6MT-ND1, MT-ND4
9QH2249.6MT-ND4, MT-ND1
10Ubiquinone Q2249.5MT-ND1, MT-ND4
11alpha-ketoglutarate459.5DLAT, PDHX
12Ubiquinone Q1249.4MT-ND1, MT-ND4
13nad29 2410.3DLAT, MT-ND1, MT-ND4
14nadh45 24 1111.3MT-ND4, MT-ND1, DLAT
15pyruvate459.1DLAT, PDHX, MT-ND1, MT-ND4

GO Terms for genes affiliated with Lactic Acidosis

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16Gene Ontology
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Cellular components related to Lactic Acidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial matrixGO:0057598.8DLAT, PDHX, YARS2, SUCLG1
2mitochondrionGO:0057398.5DLAT, YARS2, SUCLG1, PUS1, TUFM

Biological processes related to Lactic Acidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tricarboxylic acid cycleGO:0060999.8DLAT, SUCLG1
2regulation of acetyl-CoA biosynthetic process from pyruvateGO:0105109.7DLAT, PDHX
3pyruvate metabolic processGO:0060909.5DLAT, PDHX
4cellular metabolic processGO:0442379.4DLAT, PDHX, SUCLG1

Molecular functions related to Lactic Acidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1poly(A) RNA bindingGO:0448228.9YARS2, SUCLG1, PUS1, TUFM

Products for genes affiliated with Lactic Acidosis

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Sources for Lactic Acidosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet