MCID: LCT001
MIFTS: 42

Lactic Acidosis malady

Genetic diseases, Rare diseases categories

Summaries for Lactic Acidosis

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Disease Ontology:9 An acquired metabolic disease that has material basis in low ph in body tissues and blood accompanied by the buildup of lactate especially d-lactate.

MalaCards based summary: Lactic Acidosis, also known as acidosis, lactic, is related to mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes and mitochondrial myopathy and sideroblastic anemia 1. An important gene associated with Lactic Acidosis is YARS2 (tyrosyl-tRNA synthetase 2, mitochondrial), and among its related pathways are Citric acid cycle (TCA cycle) and tRNA Aminoacylation. The compounds 2-oxo acid and Lipoic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and heart.

Wikipedia:63 Lactic acidosis is a physiological condition characterized by low pH in body tissues and blood... more...

Aliases & Classifications for Lactic Acidosis

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Lactic Acidosis, Aliases & Descriptions:

Name: Lactic Acidosis 9 11
Acidosis, Lactic 60
 
Acidosis Lactic 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases


External Ids:

Disease Ontology9 DOID:3650
SNOMED-CT55 91273001
MeSH33 D000140

Related Diseases for Lactic Acidosis

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Diseases in the Lactic Acidosis family:

Lactic Acidosis Congenital Infantile Fatal Infantile Lactic Acidosis

Diseases related to Lactic Acidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 239)
idRelated DiseaseScoreTop Affiliating Genes
1mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes31.6MT-ND1, MT-ND4
2mitochondrial myopathy and sideroblastic anemia 131.3PUS1
3pyruvate dehydrogenase e1-alpha deficiency31.2PDHX, DLAT
4sideroblastic anemia31.1YARS2, PUS1
5mitochondrial disorders30.8PUS1, MT-ND4
6leigh syndrome30.4MT-ND4, PDHX
7pearson syndrome30.4SUCLG1, PUS1
8encephalomyopathy11.0
9mitochondrial encephalomyopathy11.0
10myopathy11.0
11melas syndrome10.8
12hypoglycemia10.7
13mitochondrial myopathy with lactic acidosis10.6
14hepatitis10.6
15gracile syndrome10.6
16fatal infantile lactic acidosis10.6
17myopathy, lactic acidosis, and sideroblastic anemia 210.6
18leukemia10.6
19myopathy with lactic acidosis, hereditary10.5
20pancreatitis10.5
21pyruvate carboxylase deficiency10.5
22cerebritis10.5
23short bowel syndrome10.5
24asthma10.4
25dihydrolipoamide dehydrogenase deficiency10.4
26b-cell lymphomas10.4
27hyperphosphatemia10.4
28beriberi10.4
29lymphoblastic leukemia10.4
30lactic acidosis congenital infantile10.4
31succinic acidemia lactic acidosis congenital10.4
32mitochondrial complex i deficiency10.3
33pyruvate dehydrogenase phosphatase deficiency10.3
34leigh syndrome, french-canadian type10.3
35multiple myeloma10.3
36diffuse large b-cell lymphoma10.3
37hepatitis b10.3
38acute pancreatitis10.3
39hypertrophic cardiomyopathy10.3
40ischemia10.3
41myeloma10.3
42neuropathy10.3
43aminoaciduria10.3
44mental retardation10.3
45infantile myopathy and lactic acidosis10.3
46hypoxia10.3
47fatal infantile lactic acidosis with methylmalonic aciduria10.3
48mitochondrial hypertrophic cardiomyopathy with lactic acidosis due to mto1 deficiency10.3
49growth and developmental delay-hypotonia-vision impairment-lactic acidosis syndrome10.3
50severe neonatal lactic acidosis due to nfs1-isd11 complex deficiency10.3

Graphical network of the top 20 diseases related to Lactic Acidosis:



Diseases related to lactic acidosis

Symptoms for Lactic Acidosis

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Drugs & Therapeutics for Lactic Acidosis

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Drug clinical trials:

Search ClinicalTrials for Lactic Acidosis

Search NIH Clinical Center for Lactic Acidosis

Genetic Tests for Lactic Acidosis

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Anatomical Context for Lactic Acidosis

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MalaCards organs/tissues related to Lactic Acidosis:

31
Kidney, Liver, Heart, B cells, Brain, Testes, Lung, Bone, Skeletal muscle, T cells, Bone marrow, Thyroid, Skin, Monocytes, Endothelial, Pituitary, Small intestine, Colon, Prostate, Thalamus

Animal Models for Lactic Acidosis or affiliated genes

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Publications for Lactic Acidosis

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Articles related to Lactic Acidosis:

(show top 50)    (show all 662)
idTitleAuthorsYear
1
Lactic acidosis. (25760367)
2015
2
Metformin-associated lactic acidosis. (25827456)
2015
3
Lactic Acidosis in a Patient with Type 2 Diabetes Mellitus. (25762524)
2015
4
EBV-driven HIV-associated diffuse large B-cell lymphoma causing profound lactic acidosis. (25247213)
2014
5
A patient with acute liver failure and extreme hypoglycaemia with lactic acidosis who was not in a coma: causes and consequences of lactate-protected hypoglycaemia. (24967767)
2014
6
Metformin-associated lactic acidosis requiring hospitalization. A national 10 year survey and a systematic literature review. (23436666)
2013
7
Reversible lactic acidosis in a newborn with thiamine transporter-2 deficiency. (23589815)
2013
8
Type B lactic acidosis associated with multiple myeloma. (23759296)
2013
9
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome mimicking herpes simplex encephalitis on imaging studies. (23493219)
2013
10
Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation. (21898391)
2012
11
The level of lactic acidosis affects lactate minimum in a heart rate-based lactate minimum test. (22791618)
2012
12
Central role of lactic acidosis in cancer cell resistance to glucose deprivation-induced cell death. (22190257)
2012
13
Teaching NeuroImages: mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes. (23033508)
2012
14
Metformin and lactic acidosis. (22145266)
2011
15
Dialysis therapy for lactic acidosis caused by metformin intoxication: presentation of two cases. (21441284)
2011
16
Novel compound heterozygous mutations in the fructose-1,6-bisphosphatase gene cause hypoglycemia and lactic acidosis. (20096900)
2011
17
Severe lactic acidosis after an iatrogenic propylene glycol overdose. (20099997)
2010
18
Does metformin increase the risk of fatal or nonfatal lactic acidosis? (21121550)
2010
19
D-Lactic acidosis in calves. (17933565)
2009
20
Fatal lactic acidosis after prolonged linezolid exposure for treatment of multidrug-resistant tuberculosis. (19782904)
2009
21
Mitochondrial encephalomyopathy lactic acidosis and strokelike episodes mimicking occipital idiopathic epilepsy. (19589463)
2009
22
Mitochondrial encephalopathy, lactic acidosis, and strokelike episodes: basic concepts, clinical phenotype, and therapeutic management of MELAS syndrome. (18990125)
2008
23
Metformin and lactic acidosis in an Australian community setting: the Fremantle Diabetes Study. (18429709)
2008
24
Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis. (18782901)
2008
25
Heeding clues to metformin-associated lactic acidosis: prompt response can save life. (18660415)
2008
26
Is there a role for sodium bicarbonate in treating lactic acidosis from shock? (18614899)
2008
27
Fanconi syndrome and lactic acidosis associated with stavudine and lamivudine therapy. (18580619)
2008
28
A high incidence of lactic acidosis and symptomatic hyperlactatemia in women receiving highly active antiretroviral therapy in Soweto, South Africa. (17578788)
2007
29
Severe lactic acidosis treated with prolonged hemodialysis: recovery after massive overdoses of metformin. (16423187)
2006
30
Point of care testing for antiretroviral therapy-related lactic acidosis in resource-poor settings. (16514312)
2006
31
Recurrent D-lactic acidosis in a child with short bowel syndrome. (15927940)
2005
32
D(-)-lactic acid-producing probiotics, D(-)-lactic acidosis and infants. (15565207)
2004
33
Link between metformin and lactic acidosis? (15606058)
2004
34
Treatment of HAART-induced lactic acidosis with B vitamin supplements. (16215128)
2004
35
Fulminant post-transplant lymphoproliferative disorder presenting with lactic acidosis and acute liver failure. (15199200)
2004
36
Anaesthesia for an adolescent with mitochondrial encephalomyopathy-lactic acidosis-stroke-like episodes syndrome. (12791122)
2003
37
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. (12804446)
2003
38
Fatal lactic acidosis and mimicking Guillain-BarrAc syndrome in an adolescent with human immunodeficiency virus infection. (12886900)
2003
39
Simvastatin-induced lactic acidosis: a rare adverse reaction? (12386648)
2002
40
Ketoacidosis accompanied by epileptic seizures in a patient with diabetes mellitus and mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). (11119021)
2000
41
Increased prevalence of vitiligo, but no evidence of premature ageing, in the skin of patients with bp 3243 mutation in mitochondrial DNA in the mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome (MELAS). (10233312)
1999
42
Familial occurrence of intestinal obstruction in children with the syndrome of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). (9869067)
1998
43
Diagnosis of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes in a Chinese family by PCR/restriction enzyme analysis. (16696023)
1995
44
Pancreatic beta-cell secretory defect associated with mitochondrial point mutation of the tRNA(LEU(UUR)) gene: a study in seven families with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS). (7988784)
1994
45
Proton magnetic resonance spectroscopy studies in lactic acidosis and mitochondrial disorders. (8412023)
1993
46
HMPAO-SPECT imaging resembling Alzheimer-type dementia in mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS). (2213201)
1990
47
Lactic acidosis increases tumor necrosis factor secretion and transcription in vitro. (2214745)
1990
48
Increased accumulation of N-isopropyl-p-(123I)-iodoamphetamine in two cases with mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS). (2636890)
1989
49
Partial pyruvate decarboxylase deficiency with profound lactic acidosis and hyperammonemia: responses to dichloroacetate and benzoate. (4050860)
1985
50
Urinary organic acids in a case of congenital lactic acidosis due to pyruvate decarboxylase deficiency. (117229)
1978

Variations for Lactic Acidosis

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Expression for genes affiliated with Lactic Acidosis

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Search GEO for disease gene expression data for Lactic Acidosis.

Pathways for genes affiliated with Lactic Acidosis

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Compounds for genes affiliated with Lactic Acidosis

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Sources:
43Novoseek, 24HMDB, 12DrugBank, 28IUPHAR
See all sources

Compounds related to Lactic Acidosis according to GeneCards Suite gene sharing:

(show all 15)
idCompoundScoreTop Affiliating Genes
12-oxo acid4310.0DLAT, PDHX
2Lipoic acid24 1211.0DLAT, PDHX
3dihydrolipoamide43 2411.0PDHX, DLAT
4alpha lipoic acid439.9DLAT, PDHX
5Coenzyme A24 1210.8DLAT, SUCLG1
6Ubiquinol 8249.7MT-ND1, MT-ND4
7trna439.7PUS1, TUFM
8Sulfide249.6MT-ND1, MT-ND4
9QH2249.6MT-ND4, MT-ND1
10Ubiquinone Q2249.5MT-ND1, MT-ND4
11alpha-ketoglutarate439.5DLAT, PDHX
12Ubiquinone Q1249.4MT-ND1, MT-ND4
13nad28 2410.3DLAT, MT-ND1, MT-ND4
14nadh43 24 1211.3MT-ND4, MT-ND1, DLAT
15pyruvate439.1DLAT, PDHX, MT-ND1, MT-ND4

GO Terms for genes affiliated with Lactic Acidosis

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Cellular components related to Lactic Acidosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial matrixGO:00057598.8DLAT, PDHX, YARS2, SUCLG1
2mitochondrionGO:00057398.5DLAT, YARS2, SUCLG1, PUS1, TUFM

Biological processes related to Lactic Acidosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tricarboxylic acid cycleGO:00060999.8DLAT, SUCLG1
2regulation of acetyl-CoA biosynthetic process from pyruvateGO:00105109.7DLAT, PDHX
3pyruvate metabolic processGO:00060909.5DLAT, PDHX
4cellular metabolic processGO:00442379.4DLAT, PDHX, SUCLG1

Molecular functions related to Lactic Acidosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1poly(A) RNA bindingGO:00448228.9YARS2, SUCLG1, PUS1, TUFM

Products for genes affiliated with Lactic Acidosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Lactic Acidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet