MCID: LCT001
MIFTS: 49

Lactic Acidosis malady

Summaries for Lactic Acidosis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An acquired metabolic disease that has material basis in low ph in body tissues and blood accompanied by the buildup of lactate especially d-lactate.

MalaCards: Lactic Acidosis, also known as acidosis, lactic, is related to myopathy and melas syndrome. An important gene associated with Lactic Acidosis is YARS2 (tyrosyl-tRNA synthetase 2, mitochondrial), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Glycolysis and gluconeogenesis (short map). The compounds nadh and 2-oxo acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and heart.

Wikipedia:63 Lactic acidosis is a physiological condition characterized by low pH in body tissues and blood... more...

Aliases & Classifications for Lactic Acidosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

lactic acidosis 8 10
acidosis, lactic 60
acidosis lactic 44


External Ids:

Disease Ontology8 DOID:3650
SNOMED-CT56 91273001
MeSH34 D000140

Related Diseases for Lactic Acidosis

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17GeneCards, 18GeneDecks
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Diseases related to Lactic Acidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1myopathy31.4PUS1
2melas syndrome31.1MT-ND5, MT-TL1
3diabetes mellitus30.9MT-ND1, PDP1
4metabolic acidosis30.8DLD, PDP1
5mitochondrial disorders30.8MT-CO3, PUS1
6pyruvate decarboxylase deficiency30.7PDHX, DLAT
7sideroblastic anemia30.7YARS2, ISCU, PUS1
8obesity30.3GHRH, PDP1
9tuberculosis30.0PDP1, NME4
10pearson syndrome30.0SUCLG1, PUS1
11leigh disease30.0PDHX, MT-ND4, MT-ND5
12merrf syndrome30.0MT-TK, MT-ND5
13mitochondrial encephalomyopathy10.9
14hypoglycemia10.7
15mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes10.6
16hepatitis10.6
17leukemia10.5
18type 2 diabetes mellitus10.5
19cerebritis10.5
20pancreatitis10.5
21gracile syndrome10.5
22short bowel syndrome10.4
23acute leukemia10.4
24myopathy, lactic acidosis, and sideroblastic anemia 210.4
25hyperphosphatemia10.4
26asthma10.4
27hodgkin's lymphoma10.4
28myopathy with deficiency of iron-sulfur cluster assembly enzyme10.4
29pyruvate carboxylase deficiency disease10.3
30hepatitis b10.3
31beriberi10.3
32lymphoblastic leukemia10.3
33mitochondrial myopathy with lactic acidosis10.3
34mitochondrial myopathy - lactic acidosis - deafness10.3
35acute pancreatitis10.3
36diabetic ketoacidosis10.3
37hepatitis c10.3
38burkitt's lymphoma10.3
39hypertrophic cardiomyopathy10.3
40hepatitis a10.3
41ischemia10.3
42neuropathy10.3
43lactic acidosis congenital infantile10.3
44succinic acidemia lactic acidosis congenital10.3
45burns10.2
46pancytopenia10.2
47status asthmaticus10.2
48biotin deficiency10.2
49renal tubular acidosis10.2
50diffuse large b-cell lymphoma10.2

Graphical network of the top 20 diseases related to Lactic Acidosis:



Diseases related to lactic acidosis

Clinical Features for Lactic Acidosis

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Drugs & Therapeutics for Lactic Acidosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lactic Acidosis

Drug clinical trials:

Search ClinicalTrials for Lactic Acidosis

Search NIH Clinical Center for Lactic Acidosis

Search CenterWatch for Lactic Acidosis

Genetic Tests for Lactic Acidosis

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Anatomical Context for Lactic Acidosis

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32MalaCards
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MalaCards organs/tissues related to Lactic Acidosis:

32
Kidney, Liver, Heart, Testes, B cells, Lung, Brain, Bone, Skeletal muscle, Endothelial, Pituitary, T cells, Monocytes, Thyroid, Bone marrow, Skin, Small intestine, Colon, Prostate, Thalamus

Animal Models for Lactic Acidosis or affiliated genes

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Publications for Lactic Acidosis

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Sources:
50PubMed
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Articles related to Lactic Acidosis:

(show top 50)    (show all 631)
idTitleAuthorsYear
1
The Role of Metformin in Metformin-Associated Lactic Acidosis (MALA): Case Series and Formulation of a Model of Pathogenesis. (23549904)
2013
2
A case of type B lactic acidosis in multiple myeloma. (23009980)
2013
3
Experimentally induced hyperchloremic and DL-lactic acidosis in calves: an attempt to study the effects of oral rehydration on acid-base status. (23415528)
2013
4
Central role of lactic acidosis in cancer cell resistance to glucose deprivation-induced cell death. (22190257)
2012
5
Teaching NeuroImages: mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes. (23033508)
2012
6
The role of nucleoside reverse transcriptase inhibitors usage in the incidence of hyperlactatemia and lactic acidosis in HIV/AIDS patients. (22658063)
2012
7
D-Lactic acidosis 25 years after bariatric surgery due to Salmonella enteritidis. (21996046)
2012
8
Adult-onset of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome presenting as acute meningoencephalitis: a case report. (20036095)
2012
9
Dialysis therapy for lactic acidosis caused by metformin intoxication: presentation of two cases. (21441284)
2011
10
Carboplatin: a new cause of severe type B lactic acidosis secondary to mitochondrial DNA damage. (20934831)
2011
11
Atypical Strokes in a Young African American Male: A Case of Mitochondrial Encephalopathy Lactic Acidosis and Stroke-Like Episodes (MELAS) Syndrome. (21789268)
2011
12
An autopsy case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) with intestinal bleeding in chronic renal failure. (21631236)
2011
13
Another explanation for decreased oxygen consumption in lactic acidosis. (20609262)
2010
14
Treatment of lactic acidosis: appropriate confusion. (20394011)
2010
15
A complex case of lactic acidosis in an HIV-positive individual. (20837672)
2010
16
False positive ethylene glycol determination by spectrophotometry in the presence of severe lactic acidosis and ketosis. (20620656)
2010
17
A case report of acute lymphoblastic leukemia complicated by lactic acidosis. (20882443)
2010
18
Cimetidine-induced lactic acidosis and acute pancreatitis. (20622719)
2010
19
Nonsense mutation in pseudouridylate synthase 1 (PUS1) in two brothers affected by myopathy, lactic acidosis and sideroblastic anaemia (MLASA). (21686963)
2009
20
Severe lactic acidosis treated with prolonged hemodiafiltration in a disseminated histoplasmosis. (19092663)
2009
21
Grapefruit juice improves glycemic control but exacerbates metformin-induced lactic acidosis in non-diabetic rats. (20094639)
2009
22
Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis. (18782901)
2008
23
Heeding clues to metformin-associated lactic acidosis: prompt response can save life. (18660415)
2008
24
Toxicogenetics of antiretroviral treatment (II): neurotoxicity, hepatotoxicity, lactic acidosis, kidney damage, and other adverse effects of antiretroviral drugs]. (18680693)
2008
25
Intrahepatic complement activation, sinusoidal endothelial injury, and lactic acidosis are associated with initial poor function of the liver after transplantation. (18337666)
2008
26
A high incidence of lactic acidosis and symptomatic hyperlactatemia in women receiving highly active antiretroviral therapy in Soweto, South Africa. (17578788)
2007
27
Nonsense mutation in pseudouridylate synthase 1 (PUS1) in two brothers affected by myopathy, lactic acidosis and sideroblastic anaemia (MLASA). (17056637)
2007
28
Acute hearing loss in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). (17966957)
2007
29
Subcutaneous fat necrosis of the newborn and lactic acidosis. (17845182)
2007
30
Pitfalls in the diagnosis of mitochondrial encephalopathy with lactic acidosis and stroke-like episodes. (16518165)
2006
31
Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis? (15909253)
2005
32
Lactic acidosis stimulates ganglioside and ceramide generation without sphingomyelin hydrolysis in rat cortical astrocytes. (15964679)
2005
33
Lactic acidosis in HIV infected children due to antiretroviral therapy. (16269849)
2005
34
Lactic acidosis and developmental delay due to deficiency of E3 binding protein (protein X) of the pyruvate dehydrogenase complex. (15303005)
2004
35
Lactic acidosis during nucleoside antiretroviral HIV therapy. (14982278)
2004
36
Drug points: Fatal lactic acidosis associated with tenofovir. (14512477)
2003
37
Alternate-sided homonymous hemianopia as the solitary presentation of mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes syndrome. (12790225)
2003
38
A 37 year old man with intermittent abdominal pain and non-lactic, non-ketone, high anion gap metabolic acidosis. (16573458)
2003
39
Fatal lactic acidosis during antiretroviral therapy. (14525648)
2003
40
Case study: metformin-associated lactic acidosis: could orlistat be relevant? (12882884)
2003
41
Lack of correlation between length variation in the DNA polymerase gamma gene CAG repeat and lactic acidosis or neuropathy during antiretroviral treatment. (12036482)
2002
42
Reversible fulminant lactic acidosis and liver failure in an infant with hepatic cytochrome-c oxidase deficiency. (12408186)
2002
43
Iron-overload disease in infants involving fetal growth retardation, lactic acidosis, liver haemosiderosis, and aminoaciduria. (9482441)
1998
44
A case of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes associated with diabetes mellitus and hypothalamo-pituitary dysfunction. (9622295)
1997
45
Alzheimer-type pathology in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). (8870835)
1996
46
Deficiency of the adenine nucleotide translocator in muscle of a patient with myopathy and lactic acidosis: a new mitochondrial defect. (8479824)
1993
47
Reductions in exercise lactic acidosis and ventilation as a result of exercise training in patients with obstructive lung disease. (1986689)
1991
48
Succinic acidemia: a new syndrome of organic acidemia associated with congenital lactic acidosis and decreased NADH-cytochrome c reductase activity. (3383430)
1988
49
Hyporeninemic hypoaldosteronism in a child with lactic acidosis, deafness, and mental retardation. (7040624)
1982
50
Gas chromatographic and mass spectrometric studies on urinary organic acids in a patient with congenital lactic acidosis due to pyruvate decarboxylase deficiency. (19171)
1977

Genetic Variations for Lactic Acidosis

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Expression for genes affiliated with Lactic Acidosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lactic Acidosis

Search GEO for disease gene expression data for Lactic Acidosis.

Pathways for genes affiliated with Lactic Acidosis

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Lactic Acidosis

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Lactic Acidosis according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1nadh44 11 2412.8DLAT, DLD, MT-CO3, MT-ND5, MT-ND4, PDP1
22-oxo acid4410.8DLAT, DLD, PDHX, PDP1
3pyruvate4410.8DLAT, DLD, MT-ND4, MT-ND1, PDHX, PDP1
4dihydrolipoamide44 2411.8DLAT, DLD, PDHX, PDP1
5nad28 2411.8MT-ND4, MT-ND5, MT-ND1, DLAT, MT-ND6, DLD
6alpha lipoic acid4410.8PDP1, PDHX, DLD, DLAT
7alpha-ketoglutarate4410.8DLAT, DLD, PDHX, PDP1
8valine4410.8DLD, MT-ND5, MT-ND4, MT-ND1, MT-ND6
9atp44 2811.7NME4, PDP1, MT-ND1, MT-ND4, MT-ND5, MT-CO3
10Lipoic Acid11 2411.7PDHX, DLAT
11lipoamide44 2411.7DLD, PDP1
12Coenzyme A11 2411.7DLD, SUCLG1, DLAT
13glucose4410.7MT-ND4, GHRH, MT-ND1, MT-CO3, PDP1, PDHX
14nad+4410.6DLD, MT-ND4, PDP1
15serine4410.6PDP1, DLD, MT-ND5, GHRH, MT-ND6, PDHX
16N-Formylmethionine1110.6MT-CO3, MT-ND1
17iron44 2411.5MT-ND6, MT-ND1, ISCU, MT-ND4
18lactate4410.5MT-ND1, PDP1, DLD, MT-ND4
19inosine triphosphate44 2411.4SUCLG1, NME4
20alanine4410.2DLD, MT-ND5, MT-ND1, MT-ND6, PDP1

GO Terms for genes affiliated with Lactic Acidosis

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16Gene Ontology
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Cellular components related to Lactic Acidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:00573910.5TUFM, PUS1, ISCU, YARS2, MTO1, DLD
2mitochondrial matrixGO:00575910.2PDP1, PDHX, ISCU, YARS2, DLD, DLAT

Biological processes related to Lactic Acidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of acetyl-CoA biosynthetic process from pyruvateGO:01051010.6PDP1, PDHX, DLD, DLAT
2small molecule metabolic processGO:04428110.5PDHX, ISCU, DLD, DLAT, NME4, SUCLG1
3pyruvate metabolic processGO:00609010.5DLAT, DLD, PDHX, PDP1
4cellular metabolic processGO:04423710.4DLD, PDHX, PDP1, DLAT, SUCLG1
5tricarboxylic acid cycleGO:00609910.2DLD, DLAT, SUCLG1

Products for genes affiliated with Lactic Acidosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lactic Acidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet