MCID: LCT001
MIFTS: 44

Lactic Acidosis malady

Summaries for Lactic Acidosis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 An acquired metabolic disease that has material basis in low ph in body tissues and blood accompanied by the buildup of lactate especially d-lactate.

MalaCards: Lactic Acidosis, also known as acidosis, lactic, is related to melas syndrome and metabolic acidosis. An important gene associated with Lactic Acidosis is YARS2 (tyrosyl-tRNA synthetase 2, mitochondrial), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Glycolysis and gluconeogenesis (short map). The compounds nadh and 2-oxo acid have been mentioned in the context of this disorder.

Wikipedia:64 Lactic acidosis is a physiological condition characterized by low pH in body tissues and blood... more...

Aliases & Classifications for Lactic Acidosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT
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Aliases & Descriptions:

lactic acidosis 8 10
acidosis, lactic 61
acidosis lactic 45


External Ids:

Disease Ontology8 DOID:3650
SNOMED-CT57 91273001
MeSH35 D000140

Related Diseases for Lactic Acidosis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lactic Acidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1melas syndrome31.2MT-ND5, MT-TL1
2metabolic acidosis30.8DLD, PDP1
3pyruvate decarboxylase deficiency30.7PDHX, DLAT
4mitochondrial disorders30.7MT-CO3, PUS1
5mitochondrial complex i deficiency30.3MT-ND6, MT-ND5
6tuberculosis30.1PDP1, NME4
7pearson syndrome30.1SUCLG1, PUS1
8leigh disease30.1PDHX, MT-ND4, MT-ND5
9merrf syndrome30.1MT-TK, MT-ND5
10encephalomyopathy10.9
11hypoglycemia10.7
12mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes10.7
13fatal infantile lactic acidosis10.5
14asthma10.5
15short syndrome10.5
16short bowel syndrome10.5
17n syndrome10.5
18acute leukemia10.5
19hepatitis a10.5
20gracile syndrome10.5
21hepatitis c10.4
22hyperphosphatemia10.4
23myopathy, lactic acidosis, and sideroblastic anemia 210.4
24myopathy with deficiency of iron-sulfur cluster assembly enzyme10.4
25pyruvate carboxylase deficiency disease10.4
26beriberi10.4
27mitochondrial myopathy with lactic acidosis10.4
28succinic acidemia lactic acidosis congenital10.4
29mitochondrial myopathy - lactic acidosis - deafness10.4
30acute pancreatitis10.3
31hepatitis e10.3
32biotin deficiency10.3
33hepatitis d10.3
34hypertrophic cardiomyopathy10.3
35aminoaciduria10.3
36lactic acidosis congenital infantile10.3
37mental retardation10.3
38hypoxia10.3
39malaria, severe10.3
40diabetic ketoacidosis10.2
41pancytopenia10.2
42status asthmaticus10.2
43renal tubular acidosis10.2
44acute kidney failure10.2
45mitochondrial complex v deficiency10.2
46pyruvate dehydrogenase phosphatase deficiency10.2
47lipoamide dehydrogenase deficiency10.2
48sideroblastic anemia and mitochondrial myopathy10.2
49myopathy, lactic acidosis, and sideroblastic anemia 110.2
50combined oxidative phosphorylation deficiency 1010.2

Graphical network of the top 20 diseases related to Lactic Acidosis:



Diseases related to lactic acidosis

Clinical Features for Lactic Acidosis

Drugs & Therapeutics for Lactic Acidosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Lactic Acidosis

Drug clinical trials:

Search ClinicalTrials for Lactic Acidosis

Search NIH Clinical Center for Lactic Acidosis

Search CenterWatch for Lactic Acidosis

Genetic Tests for Lactic Acidosis

Anatomical Context for Lactic Acidosis

Animal Models for Lactic Acidosis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Lactic Acidosis

Sources:
51PubMed
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Articles related to Lactic Acidosis:

(show top 50)    (show all 631)
idTitleAuthorsYear
1
Salmeterol and lactic acidosis: clinical and educational aspects. (24064313)
2013
2
Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs. (22568883)
2012
3
The importance of early haemodiafiltration in the treatment of lactic acidosis associated with the administration of metformin. (23013954)
2012
4
Mutations in mitochondrially encoded complex I enzyme as the second common cause in a cohort of Chinese patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes. (21850008)
2011
5
Severe encephalopathy, lactic acidosis, vegetative instability and neuropathy with 5-Fluorouracil treatment - pyrimidine degradation defect or beriberi? (21941485)
2011
6
Carotid dissection in mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes. (21076841)
2011
7
Lactic acidosis during Entecavir treatment in decompensated hepatitis B virus-related cirrhosis. (21782535)
2011
8
Diffusion and perfusion characteristics of MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episode) in thirteen patients. (21228936)
2011
9
Fatal infantile lactic acidosis and a novel homozygous mutation in the SUCLG1 gene: a mitochondrial DNA depletion disorder. (21093335)
2011
10
Lactic acidosis after concomitant treatment with metformin and tenofovir in a patient with HIV infection. (21288314)
2011
11
Hepatic non-Hodgkin's lymphoma with lactic acidosis in HIV-infected patients: report of 2 cases. (20739590)
2010
12
Unexpected primary osseous lymphoma as the cause of lactic acidosis in a patient suffering from pancreatitis. (20838288)
2010
13
Diffuse large B-cell lymphoma in a hepatitis C virus-infected patient presenting with lactic acidosis and hypoglycemia. (20087167)
2010
14
Stavudine-induced hyperlactatemia/lactic acidosis at a tertiary communicable diseases clinic in South Africa. (20484736)
2010
15
Metformin-associated lactic acidosis: a prognostic and therapeutic study. (19487945)
2009
16
Metformin-associated lactic acidosis in type 2 diabetes mellitus: incidence and presentation in common clinical practice. (18388117)
2008
17
Phenformin-induced lactic acidosis in an older diabetic patient: a recurrent drama (phenformin and lactic acidosis). (16567854)
2006
18
A case of severe lactic acidosis associated with extreme mental stress. (15995493)
2005
19
Linezolid use associated with lactic acidosis. (15764207)
2005
20
D(-)-lactic acid-producing probiotics, D(-)-lactic acidosis and infants. (15565207)
2004
21
Lactic acidosis after cardiac surgery is associated with adverse outcome. (15138095)
2004
22
Do risk factors for lactic acidosis influence dosing of metformin? (15482389)
2004
23
Metformin-induced lactic acidosis extremely rare. (15068766)
2004
24
Severe lactic acidosis following alcohol related generalised seizures. (15549986)
2004
25
Lactic acidosis in HIV-patients--diagnosis and treatment]. (15373054)
2004
26
Anaesthesia for an adolescent with mitochondrial encephalomyopathy-lactic acidosis-stroke-like episodes syndrome. (12791122)
2003
27
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. (12804446)
2003
28
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis. (14638559)
2003
29
Risk factors for lactic acidosis in HIV-infected patients treated with nucleoside reverse-transcriptase inhibitors: a case-control study. (12746780)
2003
30
Metformin lactic acidosis, acute renal failure and rofecoxib. (14633764)
2003
31
Simvastatin-induced lactic acidosis: a rare adverse reaction? (12386648)
2002
32
Lactic acidosis after cardiac surgery is associated with polymorphisms in tumor necrosis factor and interleukin 10 genes. (12078789)
2002
33
Pathology of lethal fetal growth retardation syndrome with aminoaciduria, iron overload, and lactic acidosis (GRACILE). (11942535)
2002
34
MELAS: a neuropsychological and radiological follow-up study. Mitochondrial encephalomyopathy, lactic acidosis and stroke. (12371926)
2002
35
Ketoacidosis accompanied by epileptic seizures in a patient with diabetes mellitus and mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). (11119021)
2000
36
Mitochondrial toxicity and lactic acidosis. (12772662)
2000
37
Mouse mutants carrying deletions that remove the genes mutated in Coffin-Lowry syndrome and lactic acidosis. (9467016)
1998
38
Encephalopathy, lactic acidosis, hyperammonaemia and 5-fluorouracil toxicity. (9635854)
1998
39
Epidemiology of A3243G, the mutation for mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes: prevalence of the mutation in an adult population. (9683591)
1998
40
Anesthetic considerations in patients presenting with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome. (9390617)
1997
41
Lactic acidosis and hypoglycemia in a patient with high-grade non-Hodgkin's lymphoma and elevated circulating TNF-alpha. (8597616)
1996
42
An autopsy case of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) with a point mutation of mitochondrial DNA. (8836506)
1996
43
Pancreatic beta-cell secretory defect associated with mitochondrial point mutation of the tRNA(LEU(UUR)) gene: a study in seven families with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS). (7988784)
1994
44
The syndrome of mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes presenting without stroke. (8442706)
1993
45
Aplasia of the retinal vessels combined with optic nerve hypoplasia, neonatal epileptic seizures, and lactic acidosis due to mitochondrial complex I deficiency. (1396914)
1992
46
Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes with special reference to the mechanism of cerebral manifestations. (2515713)
1989
47
Pathogenesis of hyperphosphatemia in lactic acidosis: disparate effects of racemic (DL-) and levo (L-) lactic acid on plasma phosphorus concentration. (3938338)
1985
48
Lipoamide dehydrogenase deficiency with primary lactic acidosis: favorable response to treatment with oral lipoic acid. (6418873)
1984
49
Lactic acidosis in biotin-responsive multiple carboxylase deficiency caused by holocarboxylase synthetase deficiency of early and late onset. (6811711)
1982
50
Pyruvate dehydrogenase phosphatase deficiency: a cause of congenital chronic lactic acidosis in infancy. (172850)
1975

Genetic Variations for Lactic Acidosis

Expression for genes affiliated with Lactic Acidosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lactic Acidosis

Search GEO for disease gene expression data for Lactic Acidosis.

Pathways for genes affiliated with Lactic Acidosis

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Lactic Acidosis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR
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Compounds related to Lactic Acidosis according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1nadh45 11 2412.8DLAT, PDP1, MT-ND6, MT-ND1, MT-ND4, MT-ND5
22-oxo acid4510.8DLAT, DLD, PDHX, PDP1
3pyruvate4510.8PDP1, PDHX, MT-ND1, MT-ND4, DLD, DLAT
4dihydrolipoamide45 2411.8PDP1, PDHX, DLD, DLAT
5nad29 2411.8MT-ND6, MT-ND1, MT-ND4, MT-ND5, DLD, DLAT
6alpha lipoic acid4510.8DLAT, DLD, PDHX, PDP1
7alpha-ketoglutarate4510.8PDP1, PDHX, DLD, DLAT
8valine4510.8MT-ND6, MT-ND1, MT-ND4, MT-ND5, DLD
9atp45 2911.7PDP1, MT-ND1, MT-ND4, MT-ND5, MT-CO3, DLAT
10Lipoic Acid11 2411.7PDHX, DLAT
11lipoamide45 2411.7DLD, PDP1
12Coenzyme A11 2411.7SUCLG1, DLAT, DLD
13glucose4510.7PDP1, PDHX, GHRH, MT-ND1, MT-ND4, MT-CO3
14nad+4510.6DLD, MT-ND4, PDP1
15serine4510.6PDP1, PDHX, GHRH, MT-ND6, MT-ND1, MT-ND5
16N-Formylmethionine1110.6MT-CO3, MT-ND1
17iron45 2411.5ISCU, MT-ND6, MT-ND1, MT-ND4
18lactate4510.5DLD, MT-ND4, MT-ND1, PDP1
19inosine triphosphate45 2411.4NME4, SUCLG1
20alanine4510.2PDP1, MT-ND6, MT-ND1, MT-ND5, DLD

GO Terms for genes affiliated with Lactic Acidosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Lactic Acidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:00573910.5TUFM, PUS1, ISCU, YARS2, MTO1, DLD
2mitochondrial matrixGO:00575910.2PDP1, PDHX, ISCU, YARS2, DLD, DLAT

Biological processes related to Lactic Acidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of acetyl-CoA biosynthetic process from pyruvateGO:01051010.6DLAT, DLD, PDHX, PDP1
2small molecule metabolic processGO:04428110.5PDHX, ISCU, DLD, DLAT, NME4, SUCLG1
3pyruvate metabolic processGO:00609010.5PDP1, PDHX, DLD, DLAT
4cellular metabolic processGO:04423710.4PDP1, PDHX, DLD, DLAT, SUCLG1
5tricarboxylic acid cycleGO:00609910.2SUCLG1, DLAT, DLD

Products for genes affiliated with Lactic Acidosis

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  • Proteins
  • Lysates
  • Antibodies

Sources for Lactic Acidosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet