MCID: LCT001
MIFTS: 49

Lactic Acidosis malady

Summaries for Lactic Acidosis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An acquired metabolic disease that has material basis in low ph in body tissues and blood accompanied by the buildup of lactate especially d-lactate.

MalaCards: Lactic Acidosis, also known as acidosis, lactic, is related to myopathy and melas syndrome. An important gene associated with Lactic Acidosis is YARS2 (tyrosyl-tRNA synthetase 2, mitochondrial), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Glycolysis and gluconeogenesis (short map). The compounds nadh and 2-oxo acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and heart.

Wikipedia:63 Lactic acidosis is a physiological condition characterized by low pH in body tissues and blood... more...

Aliases & Classifications for Lactic Acidosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

lactic acidosis 8 10
acidosis, lactic 60
acidosis lactic 44


External Ids:

Disease Ontology8 DOID:3650
SNOMED-CT56 91273001
MeSH34 D000140

Related Diseases for Lactic Acidosis

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17GeneCards, 18GeneDecks
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Diseases related to Lactic Acidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1myopathy31.4PUS1
2melas syndrome31.1MT-ND5, MT-TL1
3diabetes mellitus30.9MT-ND1, PDP1
4metabolic acidosis30.8DLD, PDP1
5mitochondrial disorders30.8MT-CO3, PUS1
6pyruvate decarboxylase deficiency30.7PDHX, DLAT
7sideroblastic anemia30.7YARS2, ISCU, PUS1
8obesity30.3GHRH, PDP1
9tuberculosis30.0PDP1, NME4
10pearson syndrome30.0SUCLG1, PUS1
11leigh disease30.0PDHX, MT-ND4, MT-ND5
12merrf syndrome30.0MT-TK, MT-ND5
13mitochondrial encephalomyopathy10.9
14hypoglycemia10.7
15mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes10.6
16hepatitis10.6
17leukemia10.5
18type 2 diabetes mellitus10.5
19cerebritis10.5
20pancreatitis10.5
21gracile syndrome10.5
22short bowel syndrome10.4
23acute leukemia10.4
24myopathy, lactic acidosis, and sideroblastic anemia 210.4
25hyperphosphatemia10.4
26asthma10.4
27hodgkin's lymphoma10.4
28myopathy with deficiency of iron-sulfur cluster assembly enzyme10.4
29pyruvate carboxylase deficiency disease10.3
30hepatitis b10.3
31beriberi10.3
32lymphoblastic leukemia10.3
33mitochondrial myopathy with lactic acidosis10.3
34mitochondrial myopathy - lactic acidosis - deafness10.3
35acute pancreatitis10.3
36diabetic ketoacidosis10.3
37hepatitis c10.3
38burkitt's lymphoma10.3
39hypertrophic cardiomyopathy10.3
40hepatitis a10.3
41ischemia10.3
42neuropathy10.3
43lactic acidosis congenital infantile10.3
44succinic acidemia lactic acidosis congenital10.3
45burns10.2
46pancytopenia10.2
47status asthmaticus10.2
48biotin deficiency10.2
49renal tubular acidosis10.2
50diffuse large b-cell lymphoma10.2

Graphical network of the top 20 diseases related to Lactic Acidosis:



Diseases related to lactic acidosis

Clinical Features for Lactic Acidosis

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Drugs & Therapeutics for Lactic Acidosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lactic Acidosis

Drug clinical trials:

Search ClinicalTrials for Lactic Acidosis

Search NIH Clinical Center for Lactic Acidosis

Search CenterWatch for Lactic Acidosis

Genetic Tests for Lactic Acidosis

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Anatomical Context for Lactic Acidosis

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32MalaCards
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MalaCards organs/tissues related to Lactic Acidosis:

32
Kidney, Liver, Heart, Testes, B cells, Brain, Lung, Skeletal muscle, Bone, Endothelial, T cells, Monocytes, Bone marrow, Skin, Thyroid, Pituitary, Prostate, Colon, Small intestine, Thalamus

Animal Models for Lactic Acidosis or affiliated genes

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Publications for Lactic Acidosis

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50PubMed
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Articles related to Lactic Acidosis:

(show top 50)    (show all 631)
idTitleAuthorsYear
1
Reversible lactic acidosis in a newborn with thiamine transporter-2 deficiency. (23589815)
2013
2
Lactic acidosis induced metformin in a chronic hemodialysis patient with diabetes mellitus tip 2. (24299454)
2013
3
Pyruvate Ringer's solution corrects lactic acidosis and prolongs survival during hemorrhagic shock in rats. (24054887)
2013
4
Metformin accumulation: Lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy. (24283301)
2013
5
Lactic acidosis after resuscitation with sodium acetate. (21227457)
2012
6
Lactic acidosis in a diabetic patient treated with metformin undergoing hepatic resection. (22585204)
2012
7
Recombinant factor VIIa is effective at reversing coagulopathy in a lactic acidosis model. (22002618)
2012
8
A 36-year-old Haitian man with coma, acute kidney injury, lactic acidosis, and respiratory failure. (22948586)
2012
9
Lactic acidosis as a complication of I^-adrenergic aerosols. (21802882)
2012
10
Fixed-dose glucose-lowering drug combinations: preventable lactic acidosis. (22413720)
2012
11
Antisense oligonucleotide corrects splice abnormality in hereditary myopathy with lactic acidosis. (22155317)
2012
12
Successful treatment of thyroid crisis accompanied by hypoglycemia, lactic acidosis, and multiple organ failure. (22386356)
2012
13
Transient vision loss in a patient with severe metformin-associated lactic acidosis. (21737421)
2012
14
Novel compound heterozygous mutations in the fructose-1,6-bisphosphatase gene cause hypoglycemia and lactic acidosis. (20096900)
2011
15
Lactic acidosis and symptomatic hyperlactataemia in a randomized trial of first-line therapy in HIV-infected adults in South Africa. (21685549)
2011
16
Tissue-specific splicing of ISCU results in a skeletal muscle phenotype in myopathy with lactic acidosis, while complete loss of ISCU results in early embryonic death in mice. (21165651)
2011
17
Metformin-associated lactic acidosis (MALA): clinical profile and outcomes in patients admitted to the intensive care unit. (21261578)
2010
18
Systematic review of current guidelines, and their evidence base, on risk of lactic acidosis after administration of contrast medium for patients receiving metformin. (20032157)
2010
19
Metformin-induced encephalopathy without lactic acidosis in a patient with contraindication for metformin. (19432690)
2009
20
Eremophila glabra is an Australian plant that reduces lactic acid accumulation in an in vitro glucose challenge designed to simulate lactic acidosis in ruminants. (22444901)
2009
21
Mitochondrial encephalopathy, lactic acidosis, and strokelike episodes: basic concepts, clinical phenotype, and therapeutic management of MELAS syndrome. (18990125)
2008
22
The genomic analysis of lactic acidosis and acidosis response in human cancers. (19057672)
2008
23
Combined glycolytic production of lactate(-) and ATP(4-) derived protons (= dissociated lactic acid) is the only cause of metabolic acidosis of exercise--a note on the OH(-) absorbing function of lactate (1-) production. (18680794)
2008
24
Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes in a 69-year-old woman. (18613903)
2008
25
Metformin-associated lactic acidosis in patients with renal impairment solely due to drug accumulation? (18095950)
2008
26
Central lactic acidosis, hyperventilation, and respiratory alkalosis: leading clinical features in a 3-year-old boy with malignant meningeal melanoma. (17534659)
2008
27
Metformin-associated lactic acidosis in a pregnant patient. (18483459)
2008
28
Cardiac scintigraphic findings of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes: A case report. (19343124)
2008
29
Anesthetic management of a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) during laparotomy. (17285419)
2007
30
Type B lactic acidosis as a severe metabolic complication in lymphoma and leukemia: a case series from a single institution and literature review. (17632264)
2007
31
Lactic acidosis in HIV patients receiving highly active antiretroviral therapy. (17682581)
2007
32
Aortic rupture in mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes. (16476819)
2006
33
Severe lactic acidosis and nephrolithiasis in an infant--etiology?: type 1 glycogen storage disease (GSD). (16703371)
2006
34
Floppy kid syndrome caused by D-lactic acidosis in goat kids. (16955830)
2006
35
Lactic acidosis in Gabonese children with severe malaria is unrelated to dehydration. (16705578)
2006
36
Fatal lactic acidosis due to widespread diffusion of melanoma. (16855524)
2006
37
Evaluation of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes with magnetic resonance imaging and proton magnetic resonance spectroscopy. (17249198)
2006
38
Yeast mediates lactic acidosis suppression after antibiotic cocktail treatment in short small bowel? (16165705)
2005
39
Lactic acidosis following short-term propofol infusion may be an early warning of propofol infusion syndrome. (15841003)
2005
40
Treatment of HAART-induced lactic acidosis with B vitamin supplements. (16215128)
2004
41
Splicing error in E1alpha pyruvate dehydrogenase mRNA caused by novel intronic mutation responsible for lactic acidosis and mental retardation. (12551913)
2003
42
Lactic acidosis. (12766720)
2003
43
Severe lactic acidosis due to thiamine deficiency in a patient with B-cell leukemia/lymphoma on total parenteral nutrition during high-dose methotrexate therapy. (14663281)
2003
44
Familial occurrence of intestinal obstruction in children with the syndrome of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). (9869067)
1998
45
Transient tyrosinemia presenting as lactic acidosis in a term baby: report of one case. (7618475)
1995
46
Myopathy, lactic acidosis, and sideroblastic anemia: a new syndrome. (7726239)
1995
47
Alpha-ketoglutarate dehydrogenase deficiency presenting as congenital lactic acidosis. (1640293)
1992
48
Deficiency of the alpha and beta subunits of pyruvate dehydrogenase in a patient with lactic acidosis and unexpected sudden death. (2189731)
1990
49
Congenital lactic acidosis, alpha-ketoglutaric aciduria and variant form of maple syrup urine disease due to a single enzyme defect: dihydrolipoyl dehydrogenase deficiency. (6897145)
1982
50
Hyperphosphatemia in lactic acidosis. (408683)
1977

Genetic Variations for Lactic Acidosis

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Expression for genes affiliated with Lactic Acidosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lactic Acidosis

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Pathways for genes affiliated with Lactic Acidosis

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Lactic Acidosis

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Lactic Acidosis according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1nadh44 11 2412.8DLAT, PDP1, MT-ND6, MT-ND1, MT-ND4, MT-ND5
22-oxo acid4410.8DLAT, DLD, PDHX, PDP1
3pyruvate4410.8PDP1, PDHX, MT-ND1, MT-ND4, DLD, DLAT
4dihydrolipoamide44 2411.8PDP1, PDHX, DLD, DLAT
5nad28 2411.8MT-ND6, MT-ND1, MT-ND4, MT-ND5, DLD, DLAT
6alpha lipoic acid4410.8DLAT, DLD, PDHX, PDP1
7alpha-ketoglutarate4410.8PDP1, PDHX, DLD, DLAT
8valine4410.8MT-ND6, MT-ND1, MT-ND4, MT-ND5, DLD
9atp44 2811.7PDP1, MT-ND1, MT-ND4, MT-ND5, MT-CO3, DLAT
10Lipoic Acid11 2411.7PDHX, DLAT
11lipoamide44 2411.7DLD, PDP1
12Coenzyme A11 2411.7SUCLG1, DLAT, DLD
13glucose4410.7PDP1, PDHX, GHRH, MT-ND1, MT-ND4, MT-CO3
14nad+4410.6DLD, MT-ND4, PDP1
15serine4410.6PDP1, PDHX, GHRH, MT-ND6, MT-ND1, MT-ND5
16N-Formylmethionine1110.6MT-CO3, MT-ND1
17iron44 2411.5ISCU, MT-ND6, MT-ND1, MT-ND4
18lactate4410.5DLD, MT-ND4, MT-ND1, PDP1
19inosine triphosphate44 2411.4NME4, SUCLG1
20alanine4410.2PDP1, MT-ND6, MT-ND1, MT-ND5, DLD

GO Terms for genes affiliated with Lactic Acidosis

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16Gene Ontology
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Cellular components related to Lactic Acidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:00573910.5PUS1, ISCU, YARS2, MTO1, DLD, NME4
2mitochondrial matrixGO:00575910.2SUCLG1, PDP1, PDHX, ISCU, YARS2, DLD

Biological processes related to Lactic Acidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of acetyl-CoA biosynthetic process from pyruvateGO:01051010.6DLAT, DLD, PDHX, PDP1
2small molecule metabolic processGO:04428110.5PDHX, ISCU, DLD, DLAT, NME4, SUCLG1
3pyruvate metabolic processGO:00609010.5PDP1, PDHX, DLD, DLAT
4cellular metabolic processGO:04423710.4PDP1, PDHX, DLD, DLAT, SUCLG1
5tricarboxylic acid cycleGO:00609910.2SUCLG1, DLAT, DLD

Products for genes affiliated with Lactic Acidosis

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  • Antibodies
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Sources for Lactic Acidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet