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MCID: LCT002
MIFTS: 46

Lactose Intolerance malady

Categories: Metabolic diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Lactose Intolerance

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Aliases & Descriptions for Lactose Intolerance:

Name: Lactose Intolerance 12 25 52 41 42 14 69
Lm - Lactose Malabsorption 12
Dairy Product Intolerance 25
Milk Sugar Intolerance 25
Lactose Malabsorption 25
Hypolactasia 25
Alactasia 25

Classifications:

MalaCards categories:
Global: Metabolic diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:10604
ICD10 33 E73 E73.9
MeSH 42 D007787
NCIt 47 C3154
UMLS 69 C0022951
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Summaries for Lactose Intolerance

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MedlinePlus : 41 lactose intolerance means that you cannot digest foods with lactose in them. lactose is the sugar found in milk and foods made with milk. after eating foods with lactose in them, you may feel sick to your stomach. you may also have gas diarrhea swelling in your stomach your doctor may do a blood, breath or stool test to find out if your problems are due to lactose intolerance. lactose intolerance is not serious. eating less food with lactose, or using pills or drops to help you digest lactose usually helps. you may need to take a calcium supplement if you don't get enough of it from your diet, since milk and foods made with milk are the most common source of calcium for most people. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Lactose Intolerance, also known as lm - lactose malabsorption, is related to congenital sucrase-isomaltase deficiency with starch and lactose intolerance and lactase persistence/nonpersistence, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Lactose Intolerance is LCT (Lactase), and among its related pathways/superpathways are Metabolism and Glycosaminoglycan metabolism. The drugs Hydrocortisone and Caseins have been mentioned in the context of this disorder. Affiliated tissues include testes, small intestine and kidney.

Genetics Home Reference : 25 Lactose intolerance is an impaired ability to digest lactose, a sugar found in milk and other dairy products. Lactose is normally broken down by an enzyme called lactase, which is produced by cells in the lining of the small intestine.

Wikipedia : 71 Lactose intolerance is a condition in which people have symptoms due to the decreased ability to digest... more...

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Related Diseases for Lactose Intolerance

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Diseases related to Lactose Intolerance via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
id Related Disease Score Top Affiliating Genes
1 congenital sucrase-isomaltase deficiency with starch and lactose intolerance 12.2
2 lactase persistence/nonpersistence 11.7
3 lactase deficiency, congenital 11.3
4 diarrhea 11.3
5 short bowel syndrome 10.9
6 streptococcal group a invasive disease 10.9
7 osmotic diarrhea 10.9
8 irritable bowel syndrome 10.3
9 heterotaxy, visceral, 2, autosomal 10.1 LCT MCM6
10 osteoporosis 10.0
11 anuria 10.0 ALDOB LCT
12 colitis 10.0
13 duodenitis 10.0
14 ulcerative colitis 10.0
15 superficial mycosis 10.0 LCT SLC5A1
16 inflammatory bowel disease 9.9
17 milk allergy 9.9
18 celiac disease 9.9
19 protein-energy malnutrition 9.9
20 enteropathica 9.9
21 acrodermatitis enteropathica 9.9
22 cataract 9.9
23 gastroenteritis 9.9
24 ovarian cancer 9.9
25 acrodermatitis 9.9
26 glomerulosclerosis, focal segmental, 1 9.9 SI SLC5A1
27 dermatitis 9.7
28 colorectal cancer 9.7
29 artery disease 9.7
30 prostate cancer 9.7
31 thyroiditis 9.7
32 mucositis 9.7
33 measles 9.7
34 steatorrhea 9.7
35 coronary artery disease 9.7
36 giardiasis 9.7
37 aquagenic urticaria 9.7
38 bone fracture 9.7
39 hyperparathyroidism 9.7
40 cardiomyopathy 9.7
41 burns 9.7
42 prostatitis 9.7
43 urticaria 9.7
44 crohn's disease 9.7
45 dyspepsia 9.7
46 thalassemia 9.7
47 tropical sprue 8.8 ALDOB DOCK4 GLB1 LCT MCM6 SI

Graphical network of the top 20 diseases related to Lactose Intolerance:



Diseases related to Lactose Intolerance
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Symptoms & Phenotypes for Lactose Intolerance

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UMLS symptoms related to Lactose Intolerance:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas
Sources

Drugs & Therapeutics for Lactose Intolerance

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Drugs for Lactose Intolerance (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 112)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
2 Caseins Phase 4,Phase 2
3 Chelating Agents Phase 4
4 Corticotropin-Releasing Hormone Phase 4
5 Cortisol succinate Phase 4
6 Hormones Phase 4
7 Hydrocortisone 17-butyrate 21-propionate Phase 4
8 Hydrocortisone acetate Phase 4
9 Analgesics Phase 4,Phase 1,Phase 2
10 Central Nervous System Depressants Phase 4,Phase 1,Phase 2
11 Peripheral Nervous System Agents Phase 4,Phase 1,Phase 2
12 Adrenergic Agents Phase 4,Phase 1,Phase 2
13 Analgesics, Non-Narcotic Phase 4,Phase 1,Phase 2
14 Antidepressive Agents Phase 4,Phase 1,Phase 2
15 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2
16 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 1,Phase 2
17 Antirheumatic Agents Phase 4,Phase 1,Phase 2
18 Neurotransmitter Agents Phase 4,Phase 1,Phase 2
19 Neurotransmitter Uptake Inhibitors Phase 4,Phase 1,Phase 2
20 Psychotropic Drugs Phase 4,Phase 1,Phase 2
21
Magnesium Sulfate Approved, Vet_approved Phase 1, Phase 2 7487-88-9 24083
22
Acetazolamide Approved, Vet_approved Phase 1, Phase 2 59-66-5 1986
23
Armodafinil Approved, Investigational Phase 1, Phase 2 112111-43-0
24
Clonidine Approved Phase 1, Phase 2 4205-90-7 2803
25
Dopamine Approved Phase 1, Phase 2 51-61-6, 62-31-7 681
26
Entacapone Approved, Investigational Phase 1, Phase 2 130929-57-6 5281081
27
Indomethacin Approved, Investigational Phase 1, Phase 2 53-86-1 3715
28
Isosorbide Dinitrate Approved Phase 1, Phase 2 87-33-2 6883
29
Mecamylamine Approved Phase 1, Phase 2 60-40-2 4032
30
Memantine Approved, Investigational Phase 1, Phase 2 19982-08-2 4054
31
Midodrine Approved Phase 1, Phase 2 133163-28-7, 42794-76-3 4195
32
Modafinil Approved, Investigational Phase 1, Phase 2 68693-11-8 4236
33
Nitric Oxide Approved Phase 1, Phase 2 10102-43-9 145068
34
Octreotide Approved, Investigational Phase 1, Phase 2 83150-76-9 383414 6400441
35
Propranolol Approved, Investigational Phase 1, Phase 2 525-66-6 4946
36
Sertraline Approved Phase 1, Phase 2 79617-96-2 68617
37
Melatonin Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 73-31-4 896
38 Calcium, Dietary Phase 1, Phase 2
39 Antioxidants Phase 1, Phase 2
40 Protective Agents Phase 1, Phase 2
41 Anesthetics Phase 1, Phase 2
42 Anti-Arrhythmia Agents Phase 1, Phase 2
43 Anticonvulsants Phase 1, Phase 2
44 calcium channel blockers Phase 1, Phase 2
45 Tocolytic Agents Phase 1, Phase 2
46 Adrenergic Agonists Phase 1, Phase 2
47 Adrenergic alpha-2 Receptor Agonists Phase 1, Phase 2
48 Adrenergic alpha-Agonists Phase 1, Phase 2
49 Adrenergic Antagonists Phase 1, Phase 2
50 Adrenergic beta-Antagonists Phase 1, Phase 2

Interventional clinical trials:

(show all 46)
id Name Status NCT ID Phase
1 Evaluation of LacTEST for the Diagnosis of Hypolactasia in Adults and Elderly Patients Presenting With Clinical Symptoms of Lactose Intolerance Completed NCT02636413 Phase 4
2 Incidence of Lactose Intolerance Among Self-reported Lactose Intolerant People Completed NCT02878876 Phase 4
3 Effects Comparison of A1 and A2 Milk on Gastrointestinal Physiology, Symptoms and Cognitive Behavior Completed NCT02406469 Phase 4
4 Imaging the Effect of Experimental Stress on Small and Large Bowel Water During Fructose Absorption Completed NCT01763281 Phase 4
5 Effects of Mesalamine and Amitriptyline on Irritable Bowel Syndrome Withdrawn NCT02190526 Phase 4
6 Efficacy, Safety, and Tolerability Study of RP-G28 in Subjects With Lactose Intolerance Completed NCT02673749 Phase 2, Phase 3
7 A Non-inferiority, Multicenter and Randomized, Multiple-Dose Study About a Treatment to Hypolactasia Completed NCT01145586 Phase 3
8 A Non-inferiority, Multicenter and Randomized, Single-Dose Study About a Treatment to Hypolactasia (LAILAI) Completed NCT01145339 Phase 3
9 Evaluation of the Efficacy of a New Infant Formula in Subjects With Cow's Milk Allergy Unknown status NCT02149134 Phase 2
10 Effectiveness, Safety and Tolerability Study of RP-G28 for Symptoms Associated With Lactose Intolerance Completed NCT01113619 Phase 2
11 Magnesium Supplementation in People With XMEN Syndrome Recruiting NCT02496676 Phase 1, Phase 2
12 Treatment of Orthostatic Intolerance Active, not recruiting NCT00262470 Phase 1, Phase 2
13 HYBRID: Hydrogen Breath Test in Lactose Digestion Completed NCT02703987 Phase 1
14 Prevalence of Lactose Intolerance Following Stem Cell Transplantation Terminated NCT00247806 Phase 1
15 The Effects of Lactose Intolerance on Gastrointestinal Function and Symptoms in a Chinese Population Unknown status NCT01286597
16 Observational Study With PASCALLERG ® in Patients With Hay Fever Unknown status NCT01660737
17 Perceived Lactose Intolerance Completed NCT01331265
18 Comparison of the Colonic Metabolism in Patients With Lactose Intolerance and Healthy Controls Completed NCT02171403
19 The Effect of Probiotics on Lactose Intolerance Completed NCT01593800
20 Secondary Lactose Intolerance Due to Chronic Norovirus Infection Completed NCT01840891
21 Amount of Lactose Causing Symptoms in People With Lactose Intolerance and Ulcerative Colitis Completed NCT00403923 Early Phase 1
22 β-galactosidase Producing Probiotic Strains to Improve Lactose Digestion Completed NCT02518295
23 Effects of Raw Versus Other Milk Sources on Lactose Digestion Completed NCT01129791
24 Amount of Lactose Causing Symptoms in Lactose Intolerant People Completed NCT00395954 Early Phase 1
25 Acid Lactase in Combination With Yoghurt Bacteria for Improvement of Lactose Digestion in Lactose Malabsorbers Completed NCT01593631
26 Althera® Versus Nutramigen / Cow's Milk Intolerance Completed NCT01727115
27 Effects of Lactose on Fecal Microflora Completed NCT00599859
28 Calcium Absorption in Postmenopausal Thai Women Completed NCT02291315
29 Colonization and Persistence of Bifidobacterium Longum Completed NCT01650753
30 Endomicroscopy, IBS and Food Intolerance Completed NCT01692613
31 Effect of Fructose on Colonic Microflora Completed NCT00775567
32 Post-exercise Recovery After Dietary Protein Ingestion in Healthy Young Men (Meat-Milk Study) Completed NCT01578590
33 "Functional Bowel Disorder. Investigation in General Practice" Completed NCT01153295
34 Improving Bone Health in Adolescence Through Targeted Behavioral Intervention Completed NCT02202889
35 A 4-month Intervention of Antioxidant Supplementation in Overweight Children Completed NCT01316081
36 Effects of A2 Milk on Gastrointestinal Function in Non-lactose Milk Intolerance Recruiting NCT03060395
37 Modulation of Lactase Expression by a New PPARgamma Ligand in Duodenal Biopsies Recruiting NCT02902016
38 Whole Milk Intake and Cardio-metabolic Risk Factors Recruiting NCT02798718
39 Individualized Fortification of Breast Milk Recruiting NCT01609894
40 Fructose and Lactose Intolerance and Malabsorption in Functional Gastrointestinal Disorders Active, not recruiting NCT02085889
41 Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS) Active, not recruiting NCT01000350
42 Lactose Intolerance and Cow's Milk Protein Allergy in Non-celiac Wheat Sensitivity Patients Not yet recruiting NCT03008252
43 Fructose Breath-testing in Irritable Bowel Syndrome (IBS) Not yet recruiting NCT02614313
44 Target Fortification of Breast Milk: How Often Breast Milk Needs to be Measured? Not yet recruiting NCT02865941
45 Validation of a Home-Screening Test for Lactose Intolerance Suspended NCT00844766 Early Phase 1
46 Evaluation of Fecal Calprotectin Screening and a Gastroenterology Questionnaire for Triaging Children With Chronic Abdominal Pain and/or Diarrhea Referred to a Pediatric Gastroenterology Service Terminated NCT01866774

Search NIH Clinical Center for Lactose Intolerance

Cochrane evidence based reviews: lactose intolerance

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Genetic Tests for Lactose Intolerance

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Anatomical Context for Lactose Intolerance

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MalaCards organs/tissues related to Lactose Intolerance:

39
Testes, Small Intestine, Kidney, Bone, Colon, Lung, Prostate
Sources

Publications for Lactose Intolerance

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Articles related to Lactose Intolerance:

(show top 50) (show all 431)
id Title Authors Year
1
Patients with lactose intolerance absorb liquid levothyroxine better than tablet levothyroxine. ( 27577569 )
2016
2
Clinical evaluation, biochemistry and genetic polymorphism analysis for the diagnosis of lactose intolerance in a population from northeastern Brazil. ( 26934237 )
2016
3
Perception of lactose intolerance impairs health-related quality of life. ( 27188918 )
2016
4
Diagnosis of lactose intolerance. ( 28038856 )
2016
5
The effects of the DDS-1 strain of lactobacillus on symptomatic relief for lactose intolerance - a randomized, double-blind, placebo-controlled, crossover clinical trial. ( 27207411 )
2016
6
Prevalence and Symptom Correlation of Lactose Intolerance in the North East Part of Bangladesh. ( 26931253 )
2016
7
Erratum to: the effects of the DDS-1 strain of lactobacillus on symptomatic relief for lactose intolerance - a randomized, double-blind, placebo-controlled, crossover clinical trial. ( 27716234 )
2016
8
Lactase persistence versus lactose intolerance: Is there an intermediate phenotype? ( 26601570 )
2016
9
A relationship between vitamin D, parathyroid hormone, calcium levels and lactose intolerance in type 2 diabetic patients and healthy subjects: Vitamin D in type 2 diabetic patients. ( 27642086 )
2016
10
Do patients with lactose intolerance exhibit more frequent comorbidities than patients without lactose intolerance? An analysis of routine data from German medical practices. ( 27065730 )
2016
11
The incidence of infants with rotavirus enteritis combined with lactose intolerance. ( 27005498 )
2016
12
Differentiating milk allergy (IgE and non-IgE mediated) from lactose intolerance: understanding the underlying mechanisms and presentations. ( 27481986 )
2016
13
ORAL ADMINISTRATION OF EXOGENOUS LACTASE IN TABLETS FOR PATIENTS DIAGNOSED WITH LACTOSE INTOLERANCE DUE TO PRIMARY HYPOLACTASIA. ( 27706451 )
2016
14
The Interrelationships between Lactose Intolerance and the Modern Dairy Industry: Global Perspectives in Evolutional and Historical Backgrounds. ( 26404364 )
2015
15
Lactose intolerance. ( 26715083 )
2015
16
Lactose Intolerance in Adults: Biological Mechanism and Dietary Management. ( 26393648 )
2015
17
Congenital lactose intolerance is triggered by severe mutations on both alleles of the lactase gene. ( 25881162 )
2015
18
The management of lactose intolerance among primary care physicians and its correlation with management by gastroenterologists: the SEPD-SEMG national survey. ( 26334462 )
2015
19
P543. Assessment of lactose intolerance in ulcerative colitis patients on remission. ( 25718041 )
2015
20
Contribution of Colonic Fermentation and Fecal Water Toxicity to the Pathophysiology of Lactose-Intolerance. ( 26371036 )
2015
21
Recent Advances on Lactose Intolerance: Tolerance Thresholds and Currently Available Solutions. ( 26713460 )
2015
22
Prevalence of Lactose Malabsorption and Lactose Intolerance in Pediatric Patients with Selected Gastrointestinal Diseases. ( 26768639 )
2015
23
Probiotics for lactose intolerance and irritable bowel syndrome. ( 26087202 )
2015
24
The Diverse Forms of Lactose Intolerance and the Putative Linkage to Several Cancers. ( 26343715 )
2015
25
Self-reported lactose intolerance in clinic patients with functional gastrointestinal symptoms: prevalence, risk factors, and impact on food choices. ( 26095206 )
2015
26
Lactose intolerance in Indonesian children. ( 26715082 )
2015
27
The management of lactose intolerance among primary care physicians and its correlation with management by gastroenterologists: The SEPD-SEMG national survey. ( 26198877 )
2015
28
Lactose intolerance and risk of lung, breast and ovarian cancers: aetiological clues from a population-based study in Sweden. ( 25314053 )
2014
29
Systematic appraisal of lactose intolerance as cause of increased need for oral thyroxine. ( 24796930 )
2014
30
Lactose intolerance: new insights due to blinded testing? ( 25196189 )
2014
31
Lactose intolerance in irritable bowel syndrome patients with diarrhoea: the roles of anxiety, activation of the innate mucosal immune system and visceral sensitivity. ( 24308871 )
2014
32
Lactose intolerance is not the cause of gastrointestinal adverse effects in beta thalassemia patients treated with deferasirox. ( 24923845 )
2014
33
Lactose intolerance genetic testing: Is it useful as routine screening? Results on 1426 south-central Italy patients. ( 25281930 )
2014
34
The differences between lactose intolerance and cow's milk protein allergy. ( 24665517 )
2014
35
Prevalence of lactose intolerance in chile: a double-blind placebo study. ( 25096822 )
2014
36
An association between lactose intolerance and anthropometric variables in the Sudanese Shagia tribe (East Africa). ( 24502673 )
2014
37
Lactose intolerance and other disaccharidase deficiency. ( 24596060 )
2014
38
Perception of lactose intolerance in irritable bowel syndrome patients. ( 25089542 )
2014
39
I recently had a lactose breath test to check for lactose intolerance. I'm not lactose intolerant, but now my doctor has ordered a lactulose breath test. Why do I need two tests? ( 24818298 )
2014
40
Effect of raw milk on lactose intolerance: a randomized controlled pilot study. ( 24615309 )
2014
41
Study on influence of age, gender and genetic variants on lactose intolerance and its impact on milk intake in adult Asian Indians. ( 24734931 )
2014
42
Novel epoxy activated hydrogels for solving lactose intolerance. ( 25013804 )
2014
43
Prevalence and presentation of lactose intolerance and effects on dairy product intake in healthy subjects and patients with irritable bowel syndrome. ( 23246646 )
2013
44
Clinical implications of lactose malabsorption versus lactose intolerance. ( 23632346 )
2013
45
Milk, chocolate and Nobel prizes: potential role of lactose intolerance and chromosome 2. ( 23564928 )
2013
46
Comparison of Quick Lactose Intolerance Test in duodenal biopsies of dyspeptic patients with single nucleotide polymorphism LCT-13910C>T associated with primary hypolactasia/lactase-persistence. ( 23381829 )
2013
47
Diagnosing gastro-oesophageal reflux disease or lactose intolerance in babies who cry a lot in the first few months overlooks feeding problems. ( 23495859 )
2013
48
Perceived lactose intolerance in adult Canadians: a national survey. ( 23855270 )
2013
49
Lactose intolerance: lack of evidence for short stature or vitamin d deficiency in prepubertal children. ( 24205288 )
2013
50
Diagnosing lactose intolerance: how PAs can facilitate breastfeeding. ( 23610832 )
2013
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Variations for Lactose Intolerance

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Expression for Lactose Intolerance

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Search GEO for disease gene expression data for Lactose Intolerance.
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Pathways for Lactose Intolerance

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Pathways related to Lactose Intolerance according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Metabolism 62
Show member pathways
 13.43 ALDOB GLB1 LCT SI SLC5A1 TREH
2
Glycosaminoglycan metabolism 62
Show member pathways
 12.18 ALDOB GLB1 LCT SI SLC5A1 TREH
3
Galactose metabolism 21 37
Show member pathways
 11.54 GLB1 LCT SI TREH
4
Carbohydrate digestion and absorption 37
11.08 LCT SI SLC5A1
5
Digestion of dietary carbohydrate 62
9.75 LCT SI TREH
Sources

GO Terms for Lactose Intolerance

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Cellular components related to Lactose Intolerance according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.8 LCT SI SLC5A1

Biological processes related to Lactose Intolerance according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.33 GLB1 LCT SI
2 metabolic process GO:0008152 9.26 GLB1 LCT SI TREH
3 polysaccharide digestion GO:0044245 8.62 LCT SI

Molecular functions related to Lactose Intolerance according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.55 GLB1 LCT MCM6 SI TREH
2 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 9.13 GLB1 LCT SI
3 hydrolase activity, acting on glycosyl bonds GO:0016798 8.92 GLB1 LCT SI TREH
Sources

Sources for Lactose Intolerance

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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