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MCID: LCT002
MIFTS: 48

Lactose Intolerance

Categories: Metabolic diseases, Genetic diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Lactose Intolerance

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MalaCards integrated aliases for Lactose Intolerance:

Name: Lactose Intolerance 12 24 51 40 41 14 69 59
Lm - Lactose Malabsorption 12
Dairy Product Intolerance 24
Milk Sugar Intolerance 24
Lactose Malabsorption 24
Hypolactasia 24
Alactasia 24

Classifications:

MalaCards categories:
Global: Metabolic diseases Genetic diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:10604
ICD10 32 E73 E73.9
MeSH 41 D007787
NCIt 46 C3154
UMLS 69 C0022951
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Summaries for Lactose Intolerance

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PubMed Health : 59
About lactose intolerance: Stomach ache, bloating, "gas" and diarrhea are all typical digestive symptoms that some people have after eating or drinking dairy products. People who have difficulty digesting dairy products may only tolerate small amounts of lactose (a sugar found in milk and other dairy products). This is called lactose intolerance.But some people who are sensitive to milk might actually have a different problem. It is important to get the diagnosis right before deciding to make major changes to your diet, especially in children, teenagers and people who need more calcium.Lactose intolerance is not an allergy. This is an important difference. People who have a true milk allergy can react to even a tiny amount of dairy foods or milk. But people who are lactose intolerant can sometimes consume quite a lot of these products without having any major problems.

MalaCards based summary : Lactose Intolerance, also known as lm - lactose malabsorption, is related to lactose intolerance, adult type and diarrhea, and has symptoms including gastrointestinal gas, nausea and vomiting and icterus. An important gene associated with Lactose Intolerance is LCT (Lactase), and among its related pathways/superpathways are Metabolism and Glycosaminoglycan metabolism. The drugs Caseins and Chelating Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, small intestine and kidney.

Genetics Home Reference : 24 Lactose intolerance is an impaired ability to digest lactose, a sugar found in milk and other dairy products. Lactose is normally broken down by an enzyme called lactase, which is produced by cells in the lining of the small intestine.

MedlinePlus : 40 Lactose intolerance means that you cannot digest foods with lactose in them. Lactose is the sugar found in milk and foods made with milk. After eating foods with lactose in them, you may feel sick to your stomach. You may also have Gas Diarrhea Swelling in your stomach Your doctor may do a blood, breath or stool test to find out if your problems are due to lactose intolerance. Lactose intolerance is not serious. Eating less food with lactose, or using pills or drops to help you digest lactose usually helps. You may need to take a calcium supplement if you don't get enough of it from your diet, since milk and foods made with milk are the most common source of calcium for most people. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

Wikipedia : 72 Lactose intolerance is a condition in which people have symptoms due to the decreased ability to digest... more...

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Related Diseases for Lactose Intolerance

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Diseases in the Lactose Intolerance family:

Lactose Intolerance, Adult Type

Diseases related to Lactose Intolerance via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 lactose intolerance, adult type 33.5 LCT MCM6
2 diarrhea 31.2 LCT SI SLC5A1
3 osmotic diarrhea 31.0 LCT SLC5A1
4 congenital sucrase-isomaltase deficiency with starch and lactose intolerance 12.3
5 lactase deficiency, congenital 11.4
6 congenital short bowel syndrome 11.1
7 short bowel syndrome 11.1
8 streptococcal group a invasive disease 11.1
9 irritable bowel syndrome 10.4
10 aging 10.3
11 episodic pain syndrome, familial, 1 10.3
12 osteoporosis 10.1
13 bone mineral density quantitative trait locus 8 10.1
14 bone mineral density quantitative trait locus 15 10.1
15 celiac disease 1 10.1
16 ulcerative colitis 10.1
17 colitis 10.1
18 milk allergy 10.1
19 duodenitis 10.1
20 colorectal cancer 10.0
21 ovarian cancer 10.0
22 acrodermatitis enteropathica, zinc-deficiency type 10.0
23 cataract 10.0
24 inflammatory bowel disease 10.0
25 protein-energy malnutrition 10.0
26 gastroenteritis 10.0
27 acrodermatitis 10.0
28 enteropathica 10.0
29 arteries, anomalies of 9.8
30 blood group--diego system 9.8
31 blood group, i system 9.8
32 prostate cancer 9.8
33 urticaria, aquagenic 9.8
34 enterocolitis 9.8
35 anxiety 9.8
36 beta-thalassemia 9.8
37 autoinflammation with infantile enterocolitis 9.8
38 bone fracture 9.8
39 burns 9.8
40 coronary artery anomaly 9.8
41 crohn's disease 9.8
42 thalassemia 9.8
43 immunoglobulin alpha deficiency 9.8
44 mucositis 9.8
45 steatorrhea 9.8
46 giardiasis 9.8
47 dysentery 9.8
48 hyperparathyroidism 9.8
49 prostatitis 9.8
50 urticaria 9.8

Graphical network of the top 20 diseases related to Lactose Intolerance:



Diseases related to Lactose Intolerance
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Symptoms & Phenotypes for Lactose Intolerance

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UMLS symptoms related to Lactose Intolerance:


gastrointestinal gas, nausea and vomiting, icterus, heartburn, dyspepsia, diarrhea, constipation, abdominal pain
Sources

Drugs & Therapeutics for Lactose Intolerance

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Drugs for Lactose Intolerance (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Caseins Phase 4,Phase 2
2 Chelating Agents Phase 4
3 Bifidobacterium Nutraceutical Phase 4
4
Sorbitol Approved 50-70-4 5780
5
Menthol Approved 2216-51-5 16666
6
Chromium Approved 7440-47-3 27668
7
Vitamin A Approved, Nutraceutical, Vet_approved 68-26-8, 11103-57-4 445354
8 Calcium, Dietary
9 Anti-Infective Agents
10 Antimalarials
11 Antiparasitic Agents
12 Antiprotozoal Agents
13 Renal Agents
14 Sulfalene
15 insulin
16 Insulin, Globin Zinc
17
Bilirubin 635-65-4 5280352
18 Bone Density Conservation Agents
19 Retinol palmitate
20 Cola Nutraceutical
21 Soy Bean Nutraceutical
22 alanine Nutraceutical
23 retinol Nutraceutical

Interventional clinical trials:

(show all 40)

# Name Status NCT ID Phase Drugs
1 Evaluation of LacTEST for the Diagnosis of Hypolactasia in Adults and Elderly Patients Presenting With Clinical Symptoms of Lactose Intolerance Completed NCT02636413 Phase 4 gaxilose
2 Incidence of Lactose Intolerance Among Self-reported Lactose Intolerant People Completed NCT02878876 Phase 4
3 Effects Comparison of A1 and A2 Milk on Gastrointestinal Physiology, Symptoms and Cognitive Behavior Completed NCT02406469 Phase 4
4 NEOBIFI: Clinical Trial for the Prevention and/or Reduction of the Incidence of Colics in Infants Completed NCT03219931 Phase 4 Bifidobacterium breve BR03 and Bifidobacterium breve B632;Placebos
5 Effects of Mesalamine and Amitriptyline on Irritable Bowel Syndrome Withdrawn NCT02190526 Phase 4 Mesalazine(asacol 800 mg);Amitriptyline;placebo like asacol;placebo like amitriptyline
6 Efficacy, Safety, and Tolerability Study of RP-G28 in Subjects With Lactose Intolerance Completed NCT02673749 Phase 2, Phase 3 RP-G28
7 A Non-inferiority, Multicenter and Randomized, Multiple-Dose Study About a Treatment to Hypolactasia Completed NCT01145586 Phase 3 Lactase Oral Tablets
8 A Non-inferiority, Multicenter and Randomized, Single-Dose Study About a Treatment to Hypolactasia (LAILAI) Completed NCT01145339 Phase 3 Lactase
9 Evaluation of the Efficacy of a New Infant Formula in Subjects With Cow's Milk Allergy Unknown status NCT02149134 Phase 2
10 Effectiveness, Safety and Tolerability Study of RP-G28 for Symptoms Associated With Lactose Intolerance Completed NCT01113619 Phase 2 RP-G28 or placebo;RP-G28 or placebo
11 Prevalence of Lactose Intolerance Following Stem Cell Transplantation Terminated NCT00247806 Phase 1
12 The Effects of Lactose Intolerance on Gastrointestinal Function and Symptoms in a Chinese Population Unknown status NCT01286597
13 Perceived Lactose Intolerance Completed NCT01331265
14 Comparison of the Colonic Metabolism in Patients With Lactose Intolerance and Healthy Controls Completed NCT02171403
15 Secondary Lactose Intolerance Due to Chronic Norovirus Infection Completed NCT01840891
16 The Effect of Probiotics on Lactose Intolerance Completed NCT01593800
17 β-galactosidase Producing Probiotic Strains to Improve Lactose Digestion Completed NCT02518295
18 Amount of Lactose Causing Symptoms in People With Lactose Intolerance and Ulcerative Colitis Completed NCT00403923 Early Phase 1
19 Effects of Raw Versus Other Milk Sources on Lactose Digestion Completed NCT01129791
20 Amount of Lactose Causing Symptoms in Lactose Intolerant People Completed NCT00395954 Early Phase 1
21 Althera® Versus Nutramigen / Cow's Milk Intolerance Completed NCT01727115
22 Acid Lactase in Combination With Yoghurt Bacteria for Improvement of Lactose Digestion in Lactose Malabsorbers Completed NCT01593631
23 HYBRID: Hydrogen Breath Test in Lactose Digestion Completed NCT02703987
24 Effects of Lactose on Fecal Microflora Completed NCT00599859
25 Calcium Absorption in Postmenopausal Thai Women Completed NCT02291315
26 Colonization and Persistence of Bifidobacterium Longum Completed NCT01650753
27 Endomicroscopy, IBS and Food Intolerance Completed NCT01692613
28 Effect of Fructose on Colonic Microflora Completed NCT00775567
29 Post-exercise Recovery After Dietary Protein Ingestion in Healthy Young Men (Meat-Milk Study) Completed NCT01578590
30 Observational Study With PASCALLERG ® in Patients With Hay Fever Completed NCT01660737
31 "Functional Bowel Disorder. Investigation in General Practice" Completed NCT01153295
32 Improving Bone Health in Adolescence Through Targeted Behavioral Intervention Completed NCT02202889
33 Lactose Intolerance and Cow's Milk Protein Allergy in Non-celiac Wheat Sensitivity Patients Recruiting NCT03008252
34 Effects of A2 Milk on Gastrointestinal Function in Non-lactose Milk Intolerance Recruiting NCT03060395
35 Modulation of Lactase Expression by a New PPARgamma Ligand in Duodenal Biopsies Recruiting NCT02902016 GED
36 Whole Milk Intake and Cardio-metabolic Risk Factors Recruiting NCT02798718
37 Fructose and Lactose Intolerance and Malabsorption in Functional Gastrointestinal Disorders Active, not recruiting NCT02085889
38 Clinical Utility of Breath Tests in GI Not yet recruiting NCT03261856
39 Validation of a Home-Screening Test for Lactose Intolerance Suspended NCT00844766 Early Phase 1
40 Evaluation of Fecal Calprotectin Screening and a Gastroenterology Questionnaire for Triaging Children With Chronic Abdominal Pain and/or Diarrhea Referred to a Pediatric Gastroenterology Service Terminated NCT01866774

Search NIH Clinical Center for Lactose Intolerance

Cochrane evidence based reviews: lactose intolerance

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Genetic Tests for Lactose Intolerance

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Anatomical Context for Lactose Intolerance

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MalaCards organs/tissues related to Lactose Intolerance:

38
Testes, Small Intestine, Kidney, Colon, Bone, Prostate, Lung
Sources

Publications for Lactose Intolerance

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Articles related to Lactose Intolerance:

(show top 50) (show all 441)
# Title Authors Year
1
Prevalence, cause and diagnosis of lactose intolerance in children aged 1-5 years: a systematic review of 1995-2015 literature. ( 29222879 )
2018
2
The effects of probiotics in lactose intolerance: A systematic review. ( 29425071 )
2018
3
Prevalence of lactose intolerance in patients with diarrhea-predominant irritable bowel syndrome: data from a tertiary center in southern China. ( 29157302 )
2017
4
Lactose Intolerance (LCT-13910C>T) Genotype Is Associated with Plasma 25-Hydroxyvitamin D Concentrations in Caucasians: A Mendelian Randomization Study. ( 28446633 )
2017
5
Lactose Intolerance and Colorectal Cancer. ( 29159160 )
2017
6
Lactase Non-persistence and Lactose Intolerance. ( 28421381 )
2017
7
Lactose intolerance and gastrointestinal cow's milk allergy in infants and children - common misconceptions revisited. ( 29270244 )
2017
8
Successful Treatment With Phenobarbital Following Lactase Supplementation in an Infant With Lactose Intolerance. ( 28821216 )
2017
9
Genetic predictors of celiac disease, lactose intolerance, and vitamin D function and presence of peptide morphins in urine of children with neurodevelopmental disorders. ( 28738753 )
2017
10
Comparison of an increased waist circumference with a positive hydrogen breath test as a clinical predictor of lactose intolerance. ( 28318180 )
2017
11
Diagnosis of genetic predisposition for lactose intolerance by high resolution melting analysis. ( 28132945 )
2017
12
The incidence of infants with rotavirus enteritis combined with lactose intolerance. ( 27005498 )
2016
13
Do patients with lactose intolerance exhibit more frequent comorbidities than patients without lactose intolerance? An analysis of routine data from German medical practices. ( 27065730 )
2016
14
A relationship between vitamin D, parathyroid hormone, calcium levels and lactose intolerance in type 2 diabetic patients and healthy subjects: Vitamin D in type 2 diabetic patients. ( 27642086 )
2016
15
Differentiating milk allergy (IgE and non-IgE mediated) from lactose intolerance: understanding the underlying mechanisms and presentations. ( 27481986 )
2016
16
The effects of the DDS-1 strain of lactobacillus on symptomatic relief for lactose intolerance - a randomized, double-blind, placebo-controlled, crossover clinical trial. ( 27207411 )
2016
17
Diagnosis of lactose intolerance. ( 28038856 )
2016
18
ORAL ADMINISTRATION OF EXOGENOUS LACTASE IN TABLETS FOR PATIENTS DIAGNOSED WITH LACTOSE INTOLERANCE DUE TO PRIMARY HYPOLACTASIA. ( 27706451 )
2016
19
Perception of lactose intolerance impairs health-related quality of life. ( 27188918 )
2016
20
Lactase persistence versus lactose intolerance: Is there an intermediate phenotype? ( 26601570 )
2016
21
Patients with lactose intolerance absorb liquid levothyroxine better than tablet levothyroxine. ( 27577569 )
2016
22
Prevalence and Symptom Correlation of Lactose Intolerance in the North East Part of Bangladesh. ( 26931253 )
2016
23
Clinical evaluation, biochemistry and genetic polymorphism analysis for the diagnosis of lactose intolerance in a population from northeastern Brazil. ( 26934237 )
2016
24
Lactose Intolerance in Adults: Biological Mechanism and Dietary Management. ( 26393648 )
2015
25
The Interrelationships between Lactose Intolerance and the Modern Dairy Industry: Global Perspectives in Evolutional and Historical Backgrounds. ( 26404364 )
2015
26
The management of lactose intolerance among primary care physicians and its correlation with management by gastroenterologists: the SEPD-SEMG national survey. ( 26334462 )
2015
27
Probiotics for lactose intolerance and irritable bowel syndrome. ( 26087202 )
2015
28
Lactose intolerance in Indonesian children. ( 26715082 )
2015
29
Prevalence of Lactose Malabsorption and Lactose Intolerance in Pediatric Patients with Selected Gastrointestinal Diseases. ( 26768639 )
2015
30
Self-reported lactose intolerance in clinic patients with functional gastrointestinal symptoms: prevalence, risk factors, and impact on food choices. ( 26095206 )
2015
31
Congenital lactose intolerance is triggered by severe mutations on both alleles of the lactase gene. ( 25881162 )
2015
32
The management of lactose intolerance among primary care physicians and its correlation with management by gastroenterologists: The SEPD-SEMG national survey. ( 26198877 )
2015
33
The Diverse Forms of Lactose Intolerance and the Putative Linkage to Several Cancers. ( 26343715 )
2015
34
Contribution of Colonic Fermentation and Fecal Water Toxicity to the Pathophysiology of Lactose-Intolerance. ( 26371036 )
2015
35
Recent Advances on Lactose Intolerance: Tolerance Thresholds and Currently Available Solutions. ( 26713460 )
2015
36
P543. Assessment of lactose intolerance in ulcerative colitis patients on remission. ( 25718041 )
2015
37
Lactose intolerance. ( 26715083 )
2015
38
Lactose intolerance and other disaccharidase deficiency. ( 24596060 )
2014
39
Lactose intolerance is not the cause of gastrointestinal adverse effects in beta thalassemia patients treated with deferasirox. ( 24923845 )
2014
40
Systematic appraisal of lactose intolerance as cause of increased need for oral thyroxine. ( 24796930 )
2014
41
Prevalence of lactose intolerance in chile: a double-blind placebo study. ( 25096822 )
2014
42
Study on influence of age, gender and genetic variants on lactose intolerance and its impact on milk intake in adult Asian Indians. ( 24734931 )
2014
43
Lactose intolerance in irritable bowel syndrome patients with diarrhoea: the roles of anxiety, activation of the innate mucosal immune system and visceral sensitivity. ( 24308871 )
2014
44
Novel epoxy activated hydrogels for solving lactose intolerance. ( 25013804 )
2014
45
I recently had a lactose breath test to check for lactose intolerance. I'm not lactose intolerant, but now my doctor has ordered a lactulose breath test. Why do I need two tests? ( 24818298 )
2014
46
An association between lactose intolerance and anthropometric variables in the Sudanese Shagia tribe (East Africa). ( 24502673 )
2014
47
Lactose intolerance: new insights due to blinded testing? ( 25196189 )
2014
48
Effect of raw milk on lactose intolerance: a randomized controlled pilot study. ( 24615309 )
2014
49
Lactose intolerance genetic testing: Is it useful as routine screening? Results on 1426 south-central Italy patients. ( 25281930 )
2014
50
The differences between lactose intolerance and cow's milk protein allergy. ( 24665517 )
2014
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Variations for Lactose Intolerance

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Expression for Lactose Intolerance

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Search GEO for disease gene expression data for Lactose Intolerance.
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Pathways for Lactose Intolerance

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Pathways related to Lactose Intolerance according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Metabolism 62
Show member pathways
 13.43 ALDOB ANPEP LCT SI SLC5A1 TREH
2
Glycosaminoglycan metabolism 62
Show member pathways
 12.3 ALDOB LCT SI SLC5A1 TREH
3
Galactose metabolism 21 36
Show member pathways
 11.52 LCT SI TREH
4
Carbohydrate digestion and absorption 36
10.78 LCT SI SLC5A1
5
Digestion of dietary carbohydrate 62
9.75 LCT SI TREH
Sources

GO Terms for Lactose Intolerance

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Biological processes related to Lactose Intolerance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metabolic process GO:0008152 9.13 LCT SI TREH
2 polysaccharide digestion GO:0044245 8.62 LCT SI

Molecular functions related to Lactose Intolerance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.55 ANPEP LCT MCM6 SI TREH
2 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 8.96 LCT SI
3 hydrolase activity, acting on glycosyl bonds GO:0016798 8.8 LCT SI TREH
Sources

Sources for Lactose Intolerance

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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