Lafora Disease malady

NIH Rare Diseases: Lafora disease is an inherited progressive myoclonus epilepsy which most commonly starts as epileptic seizures in adolescence. Most cases of Lafora disease are caused by mutations in one of two known genes: EMP2A and EMP2B. Both genes are located on chromosome 6 and are inherited in an autosomal recessive manner. A few cases of Lafora disease are caused by an as yet unidentified gene(s). Lafora disease causes seizures, muscle spasms, difficulty walking, dementia, and eventually death. There is currently no therapy that has proven effective against disease progression. Therapy is primarily palliative and aimed at reducing seizures. ³⁰

MalaCards: Lafora Disease, also known as progressive myoclonus epilepsy, lafora type, is related to seizures and epilepsy syndrome. An important gene associated with Lafora Disease is EPM2A (epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)), and among its related pathways are Ubiquitin mediated proteolysis and Regulation of degradation of wt-CFTR. The drugs primidone and anti-epileptic agent [epc] and the compounds tungstate and 4-methylumbelliferyl phosphate have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and liver, and related mouse phenotypes are liver/biliary system and muscle.

Genetics Home Reference: Lafora progressive myoclonus epilepsy is a brain disorder characterized by recurrent seizures (epilepsy) and a decline in intellectual function. The signs and symptoms of the disorder usually appear in late childhood or adolescence and worsen with time.¹⁷

Wikipedia: Lafora disease, also called Lafora progressive myoclonic epilepsy or MELF, is a fatal autosomal...⁴⁴ more...

GeneReviews summary for lafora

Aliases & Descriptions:

lafora disease 6 15 30 17 8 32 43 progressive myoclonus epilepsy, lafora type 15 16 17 myoclonic epilepsy of lafora 6 30 17 lafora progressive myoclonic epilepsy 6 16 lafora body disorder 30 16 lafora's disease 6 16 epilepsy, progressive myoclonic, lafora 17 progressive myoclonic epilepsy type 2 17 lafora progressive myoclonus epilepsy 17

myoclonic epilepsies, progressive 43 epilepsy progressive myoclonic 2 30 lafora disease (disorder) 6 epilepsies, myoclonic 43 lafora body disease 15 epilepsy 43 melf 30 epm2 30

Diseases related to lafora disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 423)

id	Related Disease	Score	Top Affiliating Genes
1	seizures	33.1	EPM2A, NHLRC1, CSTB, DUSP19, HSPA4, PARK2
2	epilepsy syndrome	32.4	EPM2A, NHLRC1, CSTB, HSPA4, CDKN3
3	merrf syndrome	31.2	CSTB, EPM2A
4	early myoclonic encephalopathy	29.4	EPM2A, CSTB
5	ataxia	27.6	HSPA4, UBC, NHLRC1, CDKN3, HSPA5, PRKAB1
6	cerebritis	26.9	PARK2, DUSP19, UBC, CDKN3, HSPA5, CLN3
7	dementia	26.5	CDKN3, CLN3, PARK2, HSPA4, CSTB, NHLRC1
8	neurodegenerative disease	26.4	STUB1, CSTB, CDKN3, DUSP19, EPM2A, NHLRC1
9	limb-girdle muscular dystrophy	26.2	UBC, TRIM32, PARK2
10	gaucher's disease	25.8	UBC, GBE1, PARK2, HSPA4
11	progressive myoclonus epilepsy	25.8	DUSP19, CLN3, PARK2, UBC, CDKN3, ACP1
12	myoclonus	25.8	EPM2A, PARK2, UBC, CDKN3, GBE1, EPM2AIP1
13	myoclonus epilepsy	25.8	GBE1, CLN3, PARK2, UBC, CDKN3, DUSP13
14	neuronitis	25.7	NNAT, UBC, STUB1, PRKAB1, CSTB, NHLRC1
15	neuropathy	24.9	PARK2, GBE1, EPM2A, NHLRC1, CSTB, PRKAB1
16	obesity	23.4	DUSP19, TRIM32, PARK2, CDKN3, ACP1, GBE1
17	neurodegeneration	23.3	STUB1, ACP1, HSPA4, CDKN3, UBC, PARK2
18	parkinson's disease	22.2	PARK2, GBE1, CDKN3, HSPA4, STUB1, HSPA5
19	ischemia	21.8	HSPA4, ACP1, PARK2, UBC, PRKAB1, CDKN3
20	glioblastoma	21.6	HSPA5, CDKN3, UBC, DUSP19, CSTB, PRKAB1
21	breast cancer	21.1	HSPA4, STUB1, PRKAB1, EPM2AIP1, HSPA5, UBC
22	bubonic plague	13.4	CDKN3, ACP1
23	ruvalcaba syndrome	13.3	CDKN3, DUSP13
24	cowden disease	13.2	DUSP19, DUSP13, CDKN3
25	limb-girdle muscular dystrophy type 2h	13.2	TRIM32, PARK2
26	tauopathy	13.0	STUB1, CDKN3, PARK2
27	bannayan-riley-ruvalcaba syndrome	12.8	CDKN3, DUSP13
28	brain ischemia	12.7	ACP1, CDKN3, HSPA4, DUSP19
29	polyposis	12.2	ACP1, UBC, CDKN3, DUSP13, DUSP19
30	japanese encephalitis	12.2	HSPA4, ACP1, HSPA5
31	ptosis	12.1	HSPA4, HSPA5, CDKN3, ACP1
32	immunodeficiency	11.8	HSPA5, CDKN3, ACP1, PARK2, HSPA4
33	retinoblastoma	11.8	ACP1, PARK2, PRKAB1, DUSP19, CDKN3, HSPA4
34	hyperglycemia	11.7	PARK2, CDKN3, HSPA5, ACP1, PRKAB1
35	hypertrophy of breast	11.5	ACP1, DUSP19, HSPA5, HSPA4, PRKAB1
36	prion disease	11.4	CDKN3, PARK2, DUSP19, CSTB, NHLRC1, EPM2A
37	colon carcinoma	11.3	HSPA4, DUSP13, HSPA5, CDKN3, ACP1, DUSP19
38	temporal lobe epilepsy	11.2
39	ovarian carcinoma	11.1	CDKN3, PARK2, UBC, HSPA4, PRKAB1, CSTB
40	thyroid carcinoma	11.1	ACP1, UBC, HSPA5, HSPA4, CDKN3
41	myopathy	11.1	CSTB, NHLRC1, EPM2A, PARK2, CDKN3, ACP1
42	amyotrophic lateral sclerosis	11.0	HSPA4, DUSP19, STUB1, HSPA5, UBC, PARK2
43	lateral sclerosis	11.0	HSPA5, HSPA4, DUSP19, STUB1, UBC, PARK2
44	cystic fibrosis	10.6	CDKN3, HSPA5, PARK2, UBC, STUB1, HSPA4
45	neuroblastoma	10.5	ACP1, NNAT, HSPA4, HSPA5, CDKN3, UBC
46	generalized epilepsy	10.2
47	retinitis	10.2	HSPA5, CDKN3, UBC, CLN3, HSPA4, TRIM32
48	myeloid leukemia	10.1	STUB1, PARK2, ACP1, UBC, HSPA4, HSPA5
49	fibrosis	10.1	ACP1, DUSP19, HSPA4, HSPA5, CDKN3, UBC
50	hepatocellular carcinoma	9.9	PRKAB2, PARK2, HSPA4, ACP1, PRKAB1, CSTB

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 anti-epileptic agent [epc], clonazepam, primidone

MalaCards organs/tissues related to lafora disease:

²²

MGI Mouse Phenotypes related to lafora disease:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	8.1	GBE1, EPM2A, NHLRC1, PRKAB2, PRKAB1, UBC
2	muscle phenotype	MP:0005369	8.1	PARK2, GBE1, EPM2A, NHLRC1, CSTB, PRKAB2
3	nervous system phenotype	MP:0003631	7.5	EPM2A, NHLRC1, CSTB, PRKAB1, STUB1, TRIM32
4	behavior/neurological phenotype	MP:0005386	7.3	EPM2A, NHLRC1, CSTB, PRKAB2, PRKAB1, STUB1
5	homeostasis/metabolism phenotype	MP:0005376	6.4	GBE1, EPM2A, NHLRC1, PRKAB2, PRKAB1, STUB1
6	cellular phenotype	MP:0005384	6.2	PRKAB1, CSTB, NHLRC1, EPM2A, GBE1, STUB1

Articles related to lafora disease:

(show all 39)

id	Title	Authors	Year	Affiliating Genes
1	Lafora disease E3-ubiquitin ligase malin is related t o TRIM32 at both the phylogenetic and functional level. (21798009)	RomA!-Mateo C.... Sanz P.	2011	TRIM32, NHLRC1
2	Lafora disease ubiquitin ligase malin promotes protea somal degradation of neuronatin and regulates glycogen synthesis. (21742036)	Sharma J.... Jana N.R.	2011	UBC, NHLRC1, NNAT
3	The laforin-malin complex, involved in Lafora disease , promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits. (20534808)	Moreno D.... Sanz P.	2010	PRKAB2, PRKAB1, EPM2A
4	Novel mutations in EPM2A and NHLRC1 widen the spectru m of Lafora disease. (20738377)	Lesca G.... Genton P.	2010	EPM2A, NHLRC1
5	Co-chaperone CHIP stabilizes aggregate-prone malin, a ubiquitin ligase mutated in Lafora disease. (19892702)	Rao S.N.... Jana N.R.	2010	STUB1, HSPA4, EPM2A
6	MR spectroscopy findings in Lafora disease. (19040628)	Altindag E.... Sirvanci M.	2009	NHLRC1
7	Increased endoplasmic reticulum stress and decreased proteasomal function in lafora disease models lacking the phosphatase laforin. (19529779)	Vernia S.... Sanz P.	2009	EPM2A, NHLRC1
8	Lafora disease and congenital generalized lipodystrop hy: a case report. (19951852)	Tseng C.F.... Wu Y.H.	2009	NHLRC1
9	Novel mutation in the NHLRC1 gene in a Malian family with a severe phenotype of Lafora disease. (19322595)	TraorAc M.... Fischbeck K.H.	2009	EPM2A, NHLRC1
10	Lafora disease in the Indian population: EPM2A and NHLRC1 gene mutations and their impact on subcellular localization of laforin and malin. (18311786)	Singh S.... Ganesh S.	2008	EPM2A, NHLRC1
11	Lafora disease proteins malin and laforin are recruited to aggresomes in response to proteasomal impairment. (17337485)	Mittal S.... Ganesh S.	2007	UBE2D1, HSPA5, UBC
12	Lafora's disease presenting with progressive myoclonus epilepsy (18033035)	Bejot Y.... Giroud M.	2007	EPM2A, NHLRC1
13	Founder effect with variable age at onset in Arab families with Lafora disease and EPM2A mutation. (17509003)	Gomez-Abad C.... Berkovic S.F.	2007	EPM2A
14	Lafora's disease (EPM2) (17304172)	Genton P.	2007	EPM2A, NHLRC1
15	Genetic diagnosis in Lafora disease: genotype-phenotype correlations and diagnostic pitfalls. (17389303)	Lohi H.... Minassian B.A.	2007	NHLRC1
16	Lafora disease. (17047580)	Madhavan D.... Kuzniecky R.I.	2006	EPM2A, NHLRC1
17	Mechanisms of unexpected and/or sudden death in Lafora disease. (16326059)	Wick R.... Byard R.W.	2006	EPM2A
18	Clinical and genetic findings in 26 Italian patients with Lafora disease. (16529633)	Franceschetti S.... Zara F.	2006	NHLRC1
19	MRI volumetry and proton MR spectroscopy of the brain in Lafora disease. (16650146)	Villanueva V.... Serratosa J.M.	2006	EPM2A
20	Molecular characterization of laforin, a dual-specificity protein phosphatase implicated in Lafora disease. (17010495)	Girard J.M.... Lederer F.	2006	ACP1, EPM2A, CDKN3
21	Late-onset and slow-progressing Lafora disease in four siblings with EPM2B mutation. (16190947)	Baykan B.... Zara F.	2005	NHLRC1
22	Transcriptional profiling of a mouse model for Lafora disease reveals dysregulation of genes involved in the expression and modification of proteins. (16084644)	Ganesh S.... Yamakawa K.	2005	NHLRC1
23	Mutations in the NHLRC1 gene are the common cause for Lafora disease in the Japanese population. (16021330)	Singh S.... Ganesh S.	2005	EPM2A, NHLRC1
24	Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin. (15930137)	Gentry M.S.... Dixon J.E.	2005	PARK2, UBC, EPM2A
25	Lafora disease due to EPM2B mutations: a clinical and genetic study. (15781812)	Gomez-Abad C.... Serratosa J.M.	2005	NHLRC1
26	The carbohydrate-binding domain of Lafora disease protein targets Lafora polyglucosan bodies. (14706656)	Ganesh S.... Yamakawa K.	2004	EPM2A
27	Progressive myoclonus epilepsy with polyglucosans (Lafora disease): evidence for a third locus. (15304597)	Chan E.M.... Minassian B.A.	2004	NHLRC1
28	Bioptically demonstrated Lafora disease without EPM2A mutation: a clinical and neurophysiological study of two sisters. (14643920)	Boccella P.... Striano S.	2003	ACP1, EPM2A
29	The Lafora disease gene product laforin interacts with HIRIP5, a phylogenetically conserved protein containing a NifU-like domain. (12915448)	Ganesh S.... Yamakawa K.	2003	EPM2A, CDKN3, NFU1
30	Skin biopsy in Lafora disease: genotype-phenotype correlations and diagnostic pitfalls. (14663053)	Andrade D.M.... Minassian B.A.	2003	EPM2A
31	Unusual presentation of Lafora's disease. (12940657)	Al Otaibi S.F.... Weiss S.	2003	EPM2A
32	Laforin, the dual-phosphatase responsible for Lafora disease, interacts with R5 (PTG), a regulatory subunit of protein phosphatase-1 that enhances glycogen accumulation. (14532330)	Fernandez-Sanchez M.E.... Rodriguez de Cordoba S.	2003	PPP1R3C, EPM2A, CDKN3
33	Lafora disease. A new case of confirmation of diagnosis on molecular genetic studies (11988905)	Martinez-Bermejo A.... Perez-Mies B.	2002	EPM2A
34	A unique carbohydrate binding domain targets the Lafora disease phosphatase to glycogen. (11739371)	Wang J.... Dixon J.E.	2002	EPM2A, CDKN3
35	Mutation screening for Japanese Lafora's disease patients: identification of novel sequence variants in the coding and upstream regulatory regions of EPM2A gene. (11735300)	Ganesh S.... Yamakawa K.	2001	EPM2A, CDKN3
36	Lafora's disease: towards a clinical, pathologic, and molecular synthesis. (11483392)	Minassian B.A.	2001	EPM2A, CDKN3
37	Identification of new and common mutations in the EPM2A gene in Lafora disease. (10668720)	Minassian B.A.... Scherer S.W.	2000	EPM2A
38	Identification of a recombination event narrowing the Lafora disease gene region. (9222970)	Maddox L.O.... Kuzniecky R.	1997	EPM2A
39	Lafora disease is not linked to the Unverricht-Lundborg locus. (7485240)	Labauge P.... Pellissier J.F.	1995	EPM2A

Genes related to lafora disease according to GeneCards:

(show all 23)

id	Symbol	Description	Score	GeneCards Section Context
1	EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	11.1	Orthologs, Aliases & Descriptions, Publications, Transcripts
2	NHLRC1	NHL repeat containing 1	11.1	Publications, Summaries
3	NFU1	NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)	11.0	Disorders, Publications
4	CSTB	cystatin B (stefin B)	11.0
5	DUSP13	dual specificity phosphatase 13	11.0
6	CLN3	ceroid-lipofuscinosis, neuronal 3	11.0
7	ACP1	acid phosphatase 1, soluble	11.0	Publications
8	CDKN3	cyclin-dependent kinase inhibitor 3	11.0	Publications
9	GBE1	glucan (1,4-alpha-), branching enzyme 1	11.0
10	DUSP19	dual specificity phosphatase 19	11.0
11	PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	11.0	Publications
12	NNAT	neuronatin	11.0	Publications
13	TUBG2	tubulin, gamma 2	11.0	Publications
14	TRIM32	tripartite motif containing 32	11.0	Publications
15	PPP1R3C	protein phosphatase 1, regulatory subunit 3C	11.0	Publications
16	EPM2AIP1	EPM2A (laforin) interacting protein 1	11.0
17	PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	11.0	Publications
18	UBE2D1	ubiquitin-conjugating enzyme E2D 1	11.0	Publications
19	STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	11.0	Publications
20	PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	11.0	Publications
21	UBC	ubiquitin C	11.0	Publications
22	HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	11.0	Publications
23	HSPA4	heat shock 70kDa protein 4	-10.0	Publications

Pathways related to lafora disease according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Ubiquitin mediated proteolysis20	8.9	NHLRC1, STUB1, TRIM32, UBE2D1, PARK2
2	Regulation of degradation of wt-CFTR41	8.7	UBC, UBE2D1, STUB1
3	Protein processing in endoplasmic reticulum20	8.5	PARK2, UBE2D1, HSPA5, STUB1
4	Parkinsons Disease Pathway36	8.5	PARK2, UBC, HSPA4, TUBG2, STUB1
5	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway10	8.4	PARK2, HSPA5, HSPA4, STUB1
6	Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway41	8.3	STUB1, HSPA4, HSPA5, PARK2
7	Proteolysis Putative ubiquitin pathway10	8.2	STUB1, HSPA4, HSPA5, UBE2D1, PARK2
8	Regulation of degradation of deltaF508 CFTR in CF41	7.8	STUB1, HSPA4, HSPA5, UBE2D1, UBC
9	Proteolysis_Putative ubiquitin pathway41	7.6	PARK2, UBC, UBE2D1, HSPA5, HSPA4, STUB1

Compounds related to lafora disease according to GeneDecks:

(show top 50)    (show all 56)

id	Compound	Score	Top Affiliating Genes
1	tungstate32	10.4	ACP1, DUSP13
2	4-methylumbelliferyl phosphate32	10.4	DUSP19, CDKN3
3	cytostatin32	10.4	CDKN3, DUSP19
4	cap-p32	10.4	CDKN3, DUSP19
5	dinophysistoxin 132	10.4	DUSP19, CDKN3
6	fostriecin32	10.3	DUSP19, CDKN3
7	tautomycin32	10.3	DUSP19, CDKN3
8	starch32	10.3	GBE1, EPM2A, ACP1
9	p-nitrophenyl phosphate32	10.2	ACP1, DUSP19, CDKN3
10	adenosine 5-o-(3-thiotriphosphate)32	10.2	CDKN3, DUSP19
11	sodium stibogluconate32 9 9	12.2	ACP1, CDKN3
12	trifluoperazine32 9 9	12.2	CDKN3, DUSP19, ACP1
13	sodium orthovanadate32	10.2	ACP1, DUSP19, CDKN3
14	microcystin-lr32	10.2	DUSP19, CDKN3
15	phenylarsine oxide32	10.2	ACP1, DUSP19, CDKN3
16	fluoride32	10.1	CDKN3, DUSP19, ACP1
17	cl 10032	10.1	CDKN3, DUSP13, DUSP19, ACP1
18	phosphothreonine32	10.1	ACP1, DUSP19, DUSP13, CDKN3
19	calyculin a32 42 9 9	13.0	ACP1, DUSP19, CDKN3
20	pt 142	9.9	PRKAB2, PRKAB1
21	dorsomorphin dihydrochloride42	9.9	PRKAB2, PRKAB1
22	sams peptide42	9.9	PRKAB2, PRKAB1
23	metformin hydrochloride42	9.9	PRKAB2, PRKAB1
24	ganciclovir32 9 9	11.8	ACP1, DUSP19, CDKN3
25	inositol32	9.6	CDKN3, HSPA4, DUSP19, ACP1
26	herbimycin a32 42	10.6	CDKN3, HSPA4, DUSP19, ACP1
27	nocodazole32 42 9 9	12.6	DUSP19, TUBG2, HSPA4, CDKN3
28	azetidine32	9.6	HSPA4, HSPA5
29	nmda32 42	10.4	ACP1, DUSP19, HSPA4, CDKN3, PARK2
30	c2ceramide32	9.4	DUSP19, HSPA4, CDKN3
31	iodoacetamide32	9.3	ACP1, HSPA4, HSPA5
32	delta-12-pgj232	9.2	HSPA4, HSPA5
33	phosphoserine32 18	10.2	ACP1, DUSP19, DUSP13, HSPA5, CDKN3
34	okadaic acid32 42	10.2	ACP1, DUSP19, HSPA5, CDKN3, PARK2
35	lactacystin32	9.1	PARK2, CDKN3, HSPA5, HSPA4
36	thapsigargin32 42	9.9	DUSP19, HSPA4, HSPA5, CDKN3
37	wortmannin32 42	9.8	PRKAB1, ACP1, DUSP19, HSPA5, CDKN3
38	Adenosine monophosphate9 18 9	10.6	PRKAB2, PRKAB1, STUB1, TRIM32, UBE2D1, PARK2
39	cysteine32	8.6	CSTB, ACP1, NFU1, DUSP19, DUSP13, HSPA5
40	threonine32	8.4	PRKAB1, ACP1, DUSP19, DUSP13, HSPA5, CDKN3
41	genistein32 9 18 9	11.4	PRKAB1, ACP1, DUSP19, HSPA4, HSPA5, CDKN3
42	iron32 18	9.4	NFU1, HSPA4, HSPA5, UBE2D1, PARK2
43	superoxide32 18	9.2	PARK2, HSPA5, HSPA4, PRKAB1, CSTB
44	dopamine32 9 18 9	11.1	ACP1, DUSP19, HSPA4, HSPA5, PARK2
45	glutamine32	8.1	PRKAB1, STUB1, ACP1, HSPA4, HSPA5, PARK2
46	glycogen32 18	9.0	PARK2, GBE1, EPM2A, NHLRC1, PRKAB1, PPP1R3C
47	atp32	7.9	PRKAB1, DUSP19, HSPA4, HSPA5, CDKN3, PARK2
48	h2o232	7.9	PRKAB1, ACP1, DUSP19, DUSP13, HSPA4, HSPA5
49	tyrosine32	7.7	EPM2A, PRKAB1, STUB1, ACP1, DUSP19, DUSP13
50	serine32	7.5	CSTB, PRKAB1, ACP1, DUSP19, DUSP13, HSPA4

Cellular components related to lafora disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	AMP-activated protein kinase complex	GO:031588	9.3	PRKAB1, PRKAB2
2	endoplasmic reticulum	GO:005783	8.4	EPM2AIP1, EPM2A, NHLRC1, HSPA5, PARK2, CLN3
3	cytoplasm	GO:005737	7.1	NFU1, ACP1, STUB1, CSTB, NNAT, DUSP13
4	cytosol	GO:005829	6.5	PARK2, GBE1, EPM2A, PRKAB2, PRKAB1, STUB1

Biological processes related to lafora disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of transforming growth factor beta receptor signaling pathway	GO:030512	8.6	UBC, HSPA5, STUB1
2	positive regulation of protein ubiquitination	GO:031398	8.3	NHLRC1, STUB1, HSPA5, UBE2D1
3	protein polyubiquitination	GO:000209	8.2	PARK2, UBC, UBE2D1, TRIM32, STUB1, NHLRC1

Molecular functions related to lafora disease according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein tyrosine/serine/threonine phosphatase activity	GO:008138	10.0	CDKN3, DUSP13, EPM2A
2	protein tyrosine phosphatase activity	GO:004725	9.8	EPM2A, DUSP19, DUSP13, CDKN3
3	protein serine/threonine phosphatase activity	GO:004722	9.7	CDKN3, PPP1R3C, EPM2A
4	AMP-activated protein kinase activity	GO:004679	9.3	PRKAB1, PRKAB2
5	misfolded protein binding	GO:051787	9.2	HSPA5, STUB1
6	ubiquitin-protein ligase activity	GO:004842	8.9	NHLRC1, STUB1, TRIM32, UBE2D1, PARK2
7	protein binding	GO:005515	5.3	ACP1, STUB1, PRKAB1, PRKAB2, NHLRC1, EPM2A