Lama2-Related Muscular Dystrophy disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Aliases & Classifications for Lama2-Related Muscular Dystrophy

Sources:
²¹GeneReviews, ²²GeneTests, ²³Genetics Home Reference, ⁴⁷Novoseek, ⁶⁵UMLS
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Aliases & Descriptions for Lama2-Related Muscular Dystrophy:

Name: Lama2-Related Muscular Dystrophy ²¹ ²² ²³

Mdc1a ²¹ ²² ²³ ⁴⁷

Laminin Alpha 2-Deficient Congenital Muscular Dystrophy ²¹ ²²

Merosin-Deficient Congenital Muscular Dystrophy Type 1a ²¹ ²²

Early-Onset Laminin Alpha 2 Deficiency ²¹ ²²

Late-Onset Laminin Alpha 2 Deficiency ²¹ ²²

Muscular Dystrophy Congenital, Merosin Negative ⁶⁵

Laminin Alpha-2 Deficient Muscular Dystrophy ²³

Muscular Dystrophy Due to Lama2 Deficiency ²³

Merosin-Deficient Muscular Dystrophy ²³

Laminin Alpha 2 Deficiency ²³

Lama2 Md ²³

Mdc 1a ²²

Mdc Ia ²²

Mdcia ²²

Classifications:

MalaCards categories:
Global: Genetic diseases, Rare diseases
Anatomical: Muscle diseases, Neuronal diseases, Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

UMLS⁶⁵ C1263858

Summaries for Lama2-Related Muscular Dystrophy

Sources:
²³Genetics Home Reference, ²¹GeneReviews, ³³MalaCards
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Genetics Home Reference:²³ LAMA2-related muscular dystrophy is a disorder that causes weakness and wasting (atrophy) of muscles used for movement (skeletal muscles). This condition generally appears in one of two ways: as a severe, early-onset type or a milder, late-onset form.

MalaCards based summary: Lama2-Related Muscular Dystrophy, also known as mdc1a, is related to muscular dystrophy, congenital merosin-deficient and congenital muscular dystrophy type 1a. An important gene associated with Lama2-Related Muscular Dystrophy is LAMA2 (Laminin Subunit Alpha 2). Affiliated tissues include skeletal muscle, brain and endothelial.

GeneReviews summary for NBK97333

Related Diseases for Lama2-Related Muscular Dystrophy

Sources:
²⁰GeneCards, ¹⁹GeneAnalytics
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Diseases in the Muscular Dystrophy family:

Muscular Dystrophy, Congenital	Muscular Dystrophy, Congenital, 1b
lama2-related muscular dystrophy	Congenital Muscular Dystrophy Due to Dystroglycanopathy
Congenital Muscular Dystrophy Due to Lmna Mutation	Congenital Muscular Dystrophy Type 1a
Muscular Dystrophy - Late Onset	Progressive Muscular Dystrophy

Diseases related to Lama2-Related Muscular Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

id	Related Disease	Score
1	muscular dystrophy, congenital merosin-deficient	11.4
2	congenital muscular dystrophy type 1a	11.2
3	muscular dystrophy	10.3
4	myopathy	10.1
5	collagen vi-related myopathy	10.1

Graphical network of diseases related to Lama2-Related Muscular Dystrophy:

Symptoms for Lama2-Related Muscular Dystrophy

Drugs & Therapeutics for Lama2-Related Muscular Dystrophy

Sources:
⁴⁴NIH Clinical Center, ⁴ClinicalTrials, ⁶⁵UMLS, ⁴³NDF-RT
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Interventional clinical trials:

id	Name	Status	NCT ID	Phase
1	Congenital Muscle Disease Study of Patient and Family Reported Medical Information	Recruiting	NCT01403402
2	LAMA2-related Muscular Dystrophy Brain Study	Withdrawn	NCT01952028

Search NIH Clinical Center for Lama2-Related Muscular Dystrophy

Genetic Tests for Lama2-Related Muscular Dystrophy

Sources:
²²GeneTests
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Genetic tests related to Lama2-Related Muscular Dystrophy:

id	Genetic test	Affiliating Genes
1	Lama2-Related Muscular Dystrophy²²	LAMA2

Anatomical Context for Lama2-Related Muscular Dystrophy

Sources:
³³MalaCards
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MalaCards organs/tissues related to Lama2-Related Muscular Dystrophy:

³³

Skeletal muscle, Brain, Endothelial

Animal Models for Lama2-Related Muscular Dystrophy or affiliated genes

Publications for Lama2-Related Muscular Dystrophy

Sources:
⁵⁴PubMed
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Articles related to Lama2-Related Muscular Dystrophy:

id	Title	Authors	Year
1	Clinical and molecular genetic analysis of a family with late-onset LAMA2-related muscular dystrophy. (26304763)	Ding J.... Xiong H.	2015
2	Results of a two-year pilot study of clinical outcome measures in collagen VI-related myopathy and LAMA2-related muscular dystrophy. (25307854)	Meilleur K.G.... BAPnnemann C.G.	2014
3	LAMA2-Related Muscular Dystrophy (22675738)	Pagon R.A.... Stephens K.	1993

Genes related to Lama2-Related Muscular Dystrophy

Sources:
²⁰GeneCards, ²²GeneTests, ⁴⁷Novoseek
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Genes related to Lama2-Related Muscular Dystrophy (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication	PubmedIds
1	LAMA2	Laminin Subunit Alpha 2	130.17	Genetic Tests ²² Novoseek inferred ⁴⁷ GeneCards inferred via : Publications (show sections)	18700894, 19388593, 17949279 more 20207543, 19692349, 17438294, 11592034, 15452315, 18053718, 16487936, 19072569, 11938437, 18516331, 16084089, 19776266, 15757977