Lama2-Related Muscular Dystrophy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Aliases & Classifications for Lama2-Related Muscular Dystrophy

Sources:
¹²diseasecard, ²³GeneReviews, ²⁴GeneTests, ²⁵Genetics Home Reference, ⁵⁰Novoseek, ⁶⁸UMLS
See all MalaCards sources

Aliases & Descriptions for Lama2-Related Muscular Dystrophy:

Name: Lama2-Related Muscular Dystrophy ²³ ²⁴ ²⁵

Mdc1a ²³ ²⁴ ²⁵ ⁵⁰

Laminin Alpha 2-Deficient Congenital Muscular Dystrophy ²³ ²⁴

Merosin-Deficient Congenital Muscular Dystrophy Type 1a ²³ ²⁴

Early-Onset Laminin Alpha 2 Deficiency ²³ ²⁴

Late-Onset Laminin Alpha 2 Deficiency ²³ ²⁴

Muscular Dystrophy Congenital, Merosin Negative ⁶⁸

Laminin Alpha-2 Deficient Muscular Dystrophy ²⁵

Muscular Dystrophy Due to Lama2 Deficiency ²⁵

Merosin-Deficient Muscular Dystrophy ²⁵

Laminin Alpha 2 Deficiency ²⁵

Laminin, Alpha-2 ¹²

Lama2 Md ²⁵

Mdc 1a ²⁴

Mdc Ia ²⁴

Mdcia ²⁴

Classifications:

MalaCards categories:
Global: Genetic diseases, Rare diseases
Anatomical: Muscle diseases, Neuronal diseases, Cardiovascular diseases

See all MalaCards categories (disease lists)

Summaries for Lama2-Related Muscular Dystrophy

Sources:
²³GeneReviews, ²⁵Genetics Home Reference, ³⁶MalaCards
See all MalaCards sources

Genetics Home Reference:²⁵ LAMA2-related muscular dystrophy is a disorder that causes weakness and wasting (atrophy) of muscles used for movement (skeletal muscles). This condition generally appears in one of two ways: as a severe, early-onset type or a milder, late-onset form.

MalaCards based summary: Lama2-Related Muscular Dystrophy, also known as mdc1a, is related to congenital muscular dystrophy type 1a and muscular dystrophy, congenital merosin-deficient. An important gene associated with Lama2-Related Muscular Dystrophy is LAMA2 (Laminin Subunit Alpha 2). Affiliated tissues include skeletal muscle and brain.

GeneReviews for NBK97333

Related Diseases for Lama2-Related Muscular Dystrophy

Sources:
²⁰GeneAnalytics, ²¹GeneCards
See all MalaCards sources

Diseases in the Muscular Dystrophy family:

Muscular Dystrophy, Congenital	Muscular Dystrophy, Congenital, 1b
lama2-related muscular dystrophy	Congenital Muscular Dystrophy Due to Dystroglycanopathy
Congenital Muscular Dystrophy Due to Lmna Mutation	Congenital Muscular Dystrophy Type 1a
Progressive Muscular Dystrophy

Diseases related to Lama2-Related Muscular Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

id	Related Disease	Score
1	congenital muscular dystrophy type 1a	11.1
2	muscular dystrophy, congenital merosin-deficient	10.9
3	muscular dystrophy	10.3
4	myopathy	10.1
5	collagen vi-related myopathy	10.1

Graphical network of diseases related to Lama2-Related Muscular Dystrophy:

Symptoms & Phenotypes for Lama2-Related Muscular Dystrophy

Drugs & Therapeutics for Lama2-Related Muscular Dystrophy

Sources:
⁴ClinicalTrials, ⁴⁶NDF-RT, ⁶⁸UMLS
See all MalaCards sources

Interventional clinical trials:

id	Name	Status	NCT ID	Phase
1	Congenital Muscle Disease Study of Patient and Family Reported Medical Information	Recruiting	NCT01403402
2	LAMA2-related Muscular Dystrophy Brain Study	Withdrawn	NCT01952028

Search NIH Clinical Center for Lama2-Related Muscular Dystrophy

Genetic Tests for Lama2-Related Muscular Dystrophy

Sources:
²⁴GeneTests
See all MalaCards sources

Genetic tests related to Lama2-Related Muscular Dystrophy:

id	Genetic test	Affiliating Genes
1	Lama2-Related Muscular Dystrophy²⁴	LAMA2

Anatomical Context for Lama2-Related Muscular Dystrophy

Sources:
³⁶MalaCards
See all MalaCards sources

MalaCards organs/tissues related to Lama2-Related Muscular Dystrophy:

³⁶

Skeletal muscle, Brain

Publications for Lama2-Related Muscular Dystrophy

Sources:
⁵⁷PubMed
See all MalaCards sources

Articles related to Lama2-Related Muscular Dystrophy:

id	Title	Authors	Year
1	Upper extremity outcome measures for collagen VI-related myopathy and LAMA2-related muscular dystrophy. (28087121)	Bendixen R.M.... Meilleur K.G.	2016
2	IGF-1/GH axis enhances losartan treatment in Lama2-related muscular dystrophy. (27798092)	Accorsi A.... Girgenrath M.	2016
3	Clinical and molecular genetic analysis of a family with late-onset LAMA2-related muscular dystrophy. (26304763)	Ding J.... Xiong H.	2015
4	Results of a two-year pilot study of clinical outcome measures in collagen VI-related myopathy and LAMA2-related muscular dystrophy. (25307854)	Meilleur K.G.... BAPnnemann C.G.	2014
5	LAMA2-Related Muscular Dystrophy (22675738)	Pagon R.A.... Stephens K.	1993

Genes related to Lama2-Related Muscular Dystrophy

Sources:
²¹GeneCards, ²⁴GeneTests, ⁵⁰Novoseek
See all MalaCards sources

Genes related to Lama2-Related Muscular Dystrophy (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication	PubmedIds
1	LAMA2	Laminin Subunit Alpha 2	130.46	Genetic Tests ²⁴ Novoseek inferred ⁵⁰ GeneCards inferred via : Publications (show sections)	18700894, 19388593, 17949279 more 20207543, 19692349, 17438294, 11592034, 15452315, 18053718, 16487936, 19072569, 11938437, 18516331, 16084089, 19776266, 15757977