MCID: LMB002
MIFTS: 44

Lambert-Eaton Myasthenic Syndrome malady

Rare diseases, Neuronal diseases categories

Aliases & Classifications for Lambert-Eaton Myasthenic Syndrome

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Sources:
10Disease Ontology, 46NINDS, 47Novoseek, 12DISEASES, 51Orphanet, 65UMLS, 36MeSH, 45NIH Rare Diseases, 29ICD9CM, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet, 27ICD10
See all sources

Aliases & Descriptions for Lambert-Eaton Myasthenic Syndrome:

Name: Lambert-Eaton Myasthenic Syndrome 10 46 47 12 51 65 36
Lems 10 45
Myasthenic-Myopathic Syndrome of Lambert-Eaton 45
Myasthenic Syndrome of Lambert-Eaton 45
Lambert Eaton Myasthenic Syndrome 45
 
Lambert-Eaton Syndrome 10
Eaton Lambert Syndrome 45
Lambert Eaton Syndrome 45
Eaton-Lambert Syndrome 10


Classifications:



Characteristics (Orphanet epidemiological data):

51
lambert-eaton myasthenic syndrome:
Inheritance: Not applicable; Prevalence: <1/1000000 (Netherlands),1-9/100000 (Europe),1-9/1000000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy


External Ids:

Disease Ontology10 DOID:0050214
ICD9CM29 358.1
MeSH36 D015624
Orphanet51 43393
ICD10 via Orphanet28 G73.1
MESH via Orphanet37 D015624
UMLS via Orphanet66 C0022972
ICD1027 G73.1

Summaries for Lambert-Eaton Myasthenic Syndrome

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NINDS:46 Lambert-Eaton myasthenic syndrome (LEMS) is a disorder of the neuromuscular junction-the site where nerve cells meet muscle cells and help activate the muscles. It is caused by a disruption of electrical impulses between these nerve and muscle cells. LEMS is an autoimmune condition; in such disorders the immune system, which normally protects the body from foreign organisms, mistakenly attacks the body's own tissues. The disruption of electrical impulses is associated with antibodies produced as a consequence of this autoimmunity. Symptoms include muscle weakness, a tingling sensation in the affected areas, fatigue, and dry mouth. LEMS is closely associated with cancer, in particular small cell lung cancer. More than half the individuals diagnosed with LEMS also develop small cell lung cancer. LEMS may appear up to 3 years before cancer is diagnosed.

MalaCards based summary: Lambert-Eaton Myasthenic Syndrome, also known as lems, is related to myasthenia gravis and lung cancer. An important gene associated with Lambert-Eaton Myasthenic Syndrome is CACNB2 (Calcium Channel, Voltage-Dependent, Beta 2 Subunit), and among its related pathways are Deactivation of the beta-catenin transactivating complex and Nicotine addiction. Affiliated tissues include lung, prostate and t cells, and related mouse phenotypes are nervous system and behavior/neurological.

Disease Ontology:10 A neuromuscular junction disease that results from an abnormality of acetylcholine (ach) release at the neuromuscular junction. it results from an autoimmune attack against voltage-gated calcium channels (vgcc) on the presynaptic motor nerve terminal.

NIH Rare Diseases:45 Lambert eaton myasthenic syndrome (lems) is a disorder of the neuromuscular junction. the neuromuscular junction is the site where nerve cells meet muscle cells and help activate the muscles. this syndrome occurs when antibodies interfere with electrical impulses between the nerve and muscle cells. it may be associated with other autoimmune diseases, or more commonly coincide with or precede a diagnosis of cancer such as small cell lung cancer. symptoms may include muscle weakness, a tingling sensation in the affected areas, fatigue, and dry mouth. treatment of a underlying disorder or cancer is the first priority of treatment. last updated: 4/22/2011

Wikipedia:68 Lambert–Eaton myasthenic syndrome (LEMS, also Lambert–Eaton syndrome, or Eaton–Lambert syndrome)... more...

Related Diseases for Lambert-Eaton Myasthenic Syndrome

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Diseases related to Lambert-Eaton Myasthenic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1myasthenia gravis11.1
2lung cancer11.1
3paraneoplastic syndromes11.0
4neuromuscular disease10.9
5cerebellar degeneration10.9
6paraneoplastic neurologic disorders10.9
7autoimmune disease 410.9
8autoimmune disease 310.9
9autoimmune disease of the nervous system10.9
10hypersensitivity reaction type ii disease10.9
11nervous system cancer10.9
12neuromuscular junction disease10.9
13lambert syndrome10.9
14adult syndrome10.9
15small cell carcinoma10.9
16respiratory failure10.8
17neuronitis10.8
18subacute cerebellar degeneration10.8
19anemia, sideroblastic, pyridoxine-refractory, autosomal recessive10.7
20muscle disorders10.7
21congenital myasthenic syndrome10.7
22adenocarcinoma10.7
23lupus erythematosus10.7
24neurologic diseases10.7
25paraneoplastic cerebellar degeneration10.7
26autonomic dysfunction10.7
27systemic lupus erythematosus10.7
28arthritis10.7
29autoimmune disease of central nervous system10.7
30merkel cell carcinoma10.7
31autonomic nervous system disease10.7
32autonomic nervous system neoplasm10.7
33dermatomyositis10.7
34muscle tissue disease10.7
35myopathy10.7
36neuropathy10.7
37congenital myasthenic syndrome associated with acetylcholine receptor deficiency10.7
38rheumatoid arthritis10.6
39neuroblastoma10.6
40cerebellar ataxia10.6
41myasthenic syndrome, congenital, 1010.6
42autoimmune disease 210.6
43child syndrome10.6
44leukemia10.6
45botulism10.6
46central nervous system cancer10.6
47mediastinitis10.6
48prostatitis10.6
49transitional cell carcinoma10.6
50kid syndrome10.6

Graphical network of the top 20 diseases related to Lambert-Eaton Myasthenic Syndrome:



Diseases related to lambert-eaton myasthenic syndrome

Symptoms for Lambert-Eaton Myasthenic Syndrome

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Drugs & Therapeutics for Lambert-Eaton Myasthenic Syndrome

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Drugs for Lambert-Eaton Myasthenic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
BenzocaineapprovedPhase 215361994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
20/20 Topical Anesthetic
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Alcohol Prep Pads
Allegenal-m
Alpha-caine Topical Anesthetic
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anbesol Jr
Anbesol Maximum Strength
Anbesol Regular Strength
Anestenka
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthetic
Anesthone
Atopalm Oral Pain Relief
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Baby Anestenka
Baby Sensigel
Baby Sensigel Night Time Formula
Baby Teething Oral Pain Reliever
Bactimicina For Sore Throat
Bencocaine Topical Anesthetic
Bensokain
Benz O Sthetic
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzodent
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
Boil Ease
Boy Butter Desensitizing Lubricant
Boy Butter Extreme Desensitizing Lubricant
Boy Butter Extreme H2O Desensitizing Lubricant
Brace Relief
Budpak Baby Teething Oral Pain Reliever
Budpak Oral Maximum Strength
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Carmex Cold Sore Treatment External Analgesic
Caswell No. 430A
Cepacol Fizzlers
Cepacol Sensations Hydra
Cepacol Sensations Sore Throat Hydra citrus splash
Cepacol Sensations Warming
Certus Sting Relief Prep Pad
Chloraseptic
Chloraseptic Warming Sore Throat
Colgate Orabase
Comfortcaine Topical Anesthetic
Cvs Fast Acting Baby Teething
Cvs Maximum Strength
Cvs Maximum Strength Boil Relief
Cvs Oral Anesthetic
Cvs Pharmacy Instant Toothache
Cvs Pharmacy Maximum Strength
Cvs Pharmacy Mouth Sore Gel
Cvs Pharmacy Nighttime Oral Pain Relief
D001566
D00552
DB01086
Dental Relief
Dentek Instant Pain Relief Maximum Strength
Dermoplast
Diet Ayds
DivK1c_000932
Dollar General Toothache Relief
Dukal Sting Relief Pad
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Finafta Baby
Finafta MultiOral
Formate, Benzocaine
Gelato Topical Anesthetic
Good Neighbor Pain Relief
Goodsense Oral Pain Relief
Gps Topical Anesthetic
Gumnumb Topical Anesthetic
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Heb Severe Toothache
Herbasoul Male Genital Desensitizer Cream
 
Hurricaine
Hurricaine Topical Anesthetic
Hurricaine Topical Anesthetic Gel
Hurricaine Topical Anesthetic Liquid
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
Insect Bite Relief
Instant Toothache Pain Relief
Intense Cvs Intense Toothache
Iodent Maximum Strength Oral Analgesic
Ismile Topical Anesthetic
Jianze Sting Relief Pads
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Kank-a Mouth Pain
Keloform
Kmart Smart Sense
Kroger Toothache Pain Relief
LS-35847
Leader Oral Analgesic
Little Colds Sore Throat Relief Melt Aways
MLS001331704
MLS002153970
Makesense Junior Pain Relief
Makesense Pain Relief
Male Desensitizer Pleasure Balm
Mandelay Male Genital Desensitizer
Mark 3
Methanesulfonate, Benzocaine
MolPort-000-871-526
Mouth Sore Medication
Mouth Sore Relief Applicator
Mouth Sore Relief Professional Strength
My Fair Baby Instant Pain Relief
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Nene Dente
Norcain
Norcaine
Norcainum
Opahl
Opahl Dye Free
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orajel For All Mouth Sores Maximum Strength
Orajel For Cold Sores
Orajel For Toothache Maximum Strength
Orajel Instant Pain Relief Maximum Strength
Orajel Instant Pain Relief Regular Strength
Orajel Instant Relief For Teething Pain
Orajel Instant Relief For Teething Pain Cooling Cucumber
Orajel Instant Relief For Teething Pain Daytime Nighttime Twin Pack
Orajel Instant Relief For Teething Pain Longer Lasting
Orajel Maximum Strength
Orajel Nighttime Instant Relief For Teething Pain Longer Lasting Extra Strength
Orajel Severe Toothache Maximum Strength Fast-Acting Formula
Oral Analgesic Maximum Strength
Oral B Instant Pain Relief
Oral Gel Maximum Strength
Oral Pain Relief Anesthetic Anesthetic
Oral Pain Reliever
Oralabs Cold Sore Treatment
Orthesin
Otocain
Outgro
Pac-dent Top Gel
Pain Relief
Pain Relief Alcohol Swabs
Parathesin
Parathesin (TN)
Parathesine
Physicians Care Sting Relief Pad
Pleasure Balm Kama Sutra
Preboost
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
Purelife Topical Anesthetic
Quality Choice Maximum Strength Oral Pain Relieving
Red Cross Oral Pain Relief
Rexall Maximum Strength
Rite Aid Baby Care
Rite Aid Liquid Anesthetic Oral Pain Relief
Rite Aid Maximum Strength
Rite Aid Oral Pain Reliever
Rite Aid Professional Strength
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Sally Hansen Ouch-relief Numbing Wipes
Sally Hansen Ouch-relief Wax Kit
Sally Hansen Ouch-relief Wax Strip Kit
Sensigel
Severe Oral Pain Reliever
Sheffield Baby Teething Gel
Sheffield Pain Relief
Shunga Male Genital Desensitizer
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Sting Relief Medicated Pad
Sting Relief Pads
Tanac
Terrasil Boil Pain Relief
Tiger Supply Inc Topical Anesthetic
Top Quality Mfg. Topical Anesthetic
Topcaine
Topcare Maximum Strength
Topical Anesthetic Banana
Topical Anesthetic Bubble Gum
Topical Anesthetic Cherry
Topical Anesthetic Mint
Topical Anesthetic Pina Colada
Topical Anesthetic Raspberry
Topical Anesthetic Strawberry
UNII-U3RSY48JW5
Ultracare Anesthetic Bubble Gum
Ultracare Anesthetic Butter Rum
Ultracare Anesthetic Creme de Menthe
Ultracare Anesthetic Pina Colada
Ultracare Anesthetic Walterberry
WLN: ZR DVO2
Walgreens Baby Teething
Walgreens Intense Toothache
Walgreens Maximum Strength
Walgreens Pain Relieving For Boils
Walgreens Severe Oral Pain Reliever
Walgreens Severe Toothache Relief
Winco Foods Maximum Strength Oral Analgesic
ZINC12358719
Zilactin-b
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
2
EphedrineapprovedPhase 1, Phase 2438299-42-39294
Synonyms:
( )-Pseudoephedrine
(+)-Ephedrin
(+)-Ephedrine
(+)-Pseudoephedrine
(+)-psi-Ephedrine
(+)-threo-Ephedrine
(+-)-Ephedrine
(-)-Ephedrine
(-)-Pseudoephedrine
(-)-psi-Ephedrine
(-)-threo-Ephedrine
(1R,2R)-Ephedrine
(1R,2S)-1-Phenyl-1-hydroxy-2-methylaminopropane
(1S,2R)-Ephedrine
(L)-EPHEDRINE
--EPHEDRINE
1-EPHEDRINE
1-Sedrin
134910_ALDRICH
287636_ALDRICH
287644_ALDRICH
299-42-3
304-87-0
30987-59-8
321-96-0
321-97-1
321-98-2
37577-31-4
38732-95-5
45261_FLUKA
4607-45-8
50-98-6
50906-05-3
53214-57-6
649031_ALDRICH
6912-63-6
7009-81-6
90-82-4
968-63-8
AC-20231
AC-20292
AC1L1JGK
AC1L1NUA
AC1L1RFA
AC1L1SR1
AC1L1T31
AC1L1Y3M
AC1O8JUO
AC1Q3XJE
AC1Q3XJM
AC1Q3XJN
AC1Q59F5
AC1Q7701
AI3-02761
AKOS000268842
AR-1A0126
AR-1I7143
Acunaso
Acunaso (TN)
Afrinol
Ambap299-42-3
BIDD:GT0817
BRN 3197916
BRN 4231286
BSPBio_001946
BSPBio_001968
BSPBio_003261
Benylin Decongestant
Besan
Biophedrin
C01575
C02765
C10H15NO
CHEBI:15407
CHEBI:51209
CHEMBL1590
CHEMBL211456
CHEMBL357080
CID11972440
CID5032
CID62946
CID6710657
CID7028
CID8650
CID9294
CID9457
CPD-9954
CPDD 0049
Cenafed
D00124
D08449
DB00852
DB01364
Decofed
DivK1c_000181
DivK1c_000451
DivK1c_000461
Drixoral N.D.
EINECS 202-017-0
EINECS 202-018-6
EINECS 206-080-5
EINECS 206-292-8
EINECS 206-293-3
Eciphin
Efedrin
Efidac/24
Eltor 120
Ephedral
Ephedremal
Ephedrin
Ephedrine
Ephedrine (TN)
Ephedrine (USP)
Ephedrine [USAN:BAN]
Ephedrine l-form
Ephedrital
Ephedrol
Ephedrosan
Ephedrotal
Ephedsol
Ephendronal
Ephoxamin
Fedrin
Genaphed
HSDB 3072
HSDB 3177
I-Sedrin
I01-3584
I01-8925
I01-8928
 
IDI1_000181
IDI1_000451
IDI1_000461
Isoephedrine
Jsp005664
KBio1_000181
KBio1_000451
KBio1_000461
KBio2_001358
KBio2_001500
KBio2_003926
KBio2_004068
KBio2_006494
KBio2_006636
KBio3_001188
KBio3_001446
KBio3_002762
KBioGR_001013
KBioGR_001763
KBioSS_001358
KBioSS_001500
KST-1A9168
Kratedyn
L(+)-psi-Ephedrine
L(-)-Ephedrine
L-(+)-Ephedrine
L-(-)-Ephedrine
L-Ephedrine
L-erythro-2-(Methylamino)-1-phenylpropan-1-ol
L000968
LS-125921
LS-125922
LS-43083
LS-63961
LS-63962
LS-63963
LS-63964
Lexofedrin
Lopac-E-3250
Lopac0_000501
MLS000069657
Manadrin
Mandrin
Maxenal
MolPort-001-684-474
MolPort-001-684-477
MolPort-001-684-478
MolPort-001-684-479
MolPort-001-769-085
Myfedrine
NCGC00015408-01
NCGC00015408-02
NCGC00162174-01
NCGC00178180-01
NCGC00178889-01
NCI-C55652
NCI60_002955
NINDS_000181
NINDS_000451
NINDS_000461
NSC 165609
NSC 170951
NSC 8971
NSC165609
NSC170951
NSC8971
Nasol
Neodurasina
Neodurasina (TN)
Oprea1_287330
PDSP1_000168
PDSP1_001106
PDSP1_001343
PDSP1_001345
PDSP1_001346
PDSP1_001347
PDSP2_000167
PDSP2_001090
PDSP2_001327
PDSP2_001329
PDSP2_001330
PDSP2_001331
PSEUDOEPHEDRINE
Pedia Care
Pseudo
Pseudo 60's
Pseudo-12
Pseudoefedrina
Pseudoephedrine (D)
Pseudoephedrinum
Psi-ephedrin
Psi-ephedrine
Robidrine
SMR000059174
SPBio_000214
SPBio_001365
SPBio_001377
ST023802
STK367993
STOCK1N-42675
Sanedrine
Spectrum2_000137
Spectrum2_001303
Spectrum2_001309
Spectrum3_000414
Spectrum3_000563
Spectrum3_001771
Spectrum4_000497
Spectrum4_001162
Spectrum5_000650
Spectrum5_000879
Spectrum5_001106
Spectrum_000878
Spectrum_001020
Sudafed
Sudafed Decongestant
UNII-03VRY66076
UNII-7CUC9DDI9F
UNII-GN83C131XS
Vencipon
WLN: QYR & Y1 & M1
WLN: QYR&Y1&M1
Zephrol
d-Ephedrine
d-Isoephedrine
d-Pseudoephedrine
d-psi-Ephedrine
l-Ephedrine
l-Pseudoephedrine
racephedrine
trans-Ephedrine
3
PseudoephedrineapprovedPhase 1, Phase 243890-82-47028
Synonyms:
( )-Pseudoephedrine
(+)-(1S,2S)-Pseudoephedrine
(+)-Pseudoephedrine
(+)-Psi-ephedrine
(+)-psi-Ephedrine
(+)-threo-Ephedrine
(1S,2S)-(+)-Pseudoephedrine
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol
(1S,2S)-2-Methylamino-1-phenyl-1-propanol
(1S,2S)-Pseudoephedrine
(1S,2S)-Pseudoephedrine, polymer-bound
1-Ephedrine
2-(Methylamino)-1-phenyl-1-propanol
287636_ALDRICH
304-87-0
30987-59-8
37577-31-4
649031_ALDRICH
90-82-4
AC-20292
AC1L1NUA
Acunaso
Acunaso (TN)
Afrinol
BIDD:GT0817
BRD-K84175871-003-02-2
BSPBio_003261
Balminil Decongestant Syrup
Benylin Decongestant
Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alpha-S)- (9CI)
Besan
C02765
C10H15NO
CHEBI:51209
CHEMBL1590
CID7028
CPD-9954
Cenafed
D-Isoephedrine
D-Pseudoephedrine
D-Pseudoephedrine base
D-Psi-2-Methylamino-1-phenyl-1-propanol
D-Psi-2-methylamino-1-phenyl-1-propanol
D-Psi-Ephedrine
D-Psi-ephedrine
D08449
DB00852
Decofed
Dimetapp Decongestant
Dimetapp Decongestant Pediatric Drops
DivK1c_000451
Drixoral N.D.
Drixoral Nasal Decongestant
EINECS 202-018-6
Efidac 24 Pseudoephedrine Hcl
Efidac/24
Eltor 120
Ephed 60
Ephedrine
Genaphed
HSDB 3177
I01-8928
IDI1_000451
Isoephedrine
KBio1_000451
 
KBio2_001358
KBio2_003926
KBio2_006494
KBio3_002762
KBioGR_001763
KBioSS_001358
L(+)-Psi-Ephedrine
L(+)-Psi-ephedrine
L(+)-psi-Ephedrine
L-(+)-Pseudoephedrine
LS-125922
Lopac-E-3250
Maxenal
MolPort-001-684-474
Myfedrine
NCGC00015408-01
NCGC00178180-01
NCI60_002955
NINDS_000451
Neodurasina
Neodurasina (TN)
Novafed
PDSP1_001347
PSEUDOEPHEDRINE
Pedia Care
Pseudo
Pseudo 60's
Pseudo-12
Pseudoefedrina
Pseudoefedrina [INN-Spanish]
Pseudoephedrine
Pseudoephedrine (D)
Pseudoephedrine (INN)
Pseudoephedrine D-form
Pseudoephedrine Ephedrine
Pseudoephedrine Hydrochloride
Pseudoephedrine [INN:BAN]
Pseudoephedrine d-form
Pseudoephedrine hydrochloride
Pseudoephedrine sulfate
Pseudoephedrinum
Pseudoephedrinum [INN-Latin]
Psi-ephedrin
Psi-ephedrine
Robidrine
SPBio_001365
STOCK1N-42675
Spectrum2_001303
Spectrum3_001771
Spectrum4_001162
Spectrum5_000650
Spectrum_000878
Sudafed
Sudafed Decongestant
Sudafed Decongestant 12 Hour
Sudafed Decongestant Extra Strength
Suphedrine
Triaminic AM Decongestant Formula
Triaminic Infant Oral Decongestant Drops
UNII-7CUC9DDI9F
alpha-(1-(Methylamino)ethyl)benzyl alcohol
d-Isoephedrine
d-Pseudoephedrine
d-psi-2-Methylamino-1-phenyl-1-propanol
d-psi-Ephedrine
trans-Ephedrine
4Nasal DecongestantsPhase 1, Phase 2406
5tannic acidNutraceuticalPhase 21536
6AlbuterolPhase 1465
7Adrenergic beta-2 Receptor AgonistsPhase 1749

Interventional clinical trials:

(show all 18)
idNameStatusNCT IDPhase
1Amifampridine Phosphate for the Treatment of Pediatric Congenital Myasthenic SyndromesRecruitingNCT02562066Phase 3
2A Phase 3 Study of Amifampridine Phosphate in Patients With Lambert Eaton Myasthenic Syndrome (LEMS)Active, not recruitingNCT01377922Phase 3
3Use of 3,4-Diaminopyridine in the Treatment of Lambert-Eaton SyndromeAvailableNCT01825395Phase 3
4Effectiveness of 3,4-Diaminopyridine in Lambert-Eaton Myasthenic SyndromeActive, not recruitingNCT01511978Phase 2
5Ephedrine for the Treatment of Congenital MyastheniaEnrolling by invitationNCT00541216Phase 1, Phase 2
6Efficacy of Albuterol in the Treatment of Congenital Myasthenic SyndromesCompletedNCT01203592Phase 1
7Randomized Study of 3,4-Diaminopyridine for Lambert-Eaton Myasthenic SyndromeCompletedNCT00004832
8Pregnancy Outcomes in Congenital Myasthenie SyndromeCompletedNCT01474980
93,4-Diaminopyridine Use in Lambert-Eaton Myasthenic Syndrome(LEMS) and Congenital Myasthenic Syndromes (CMS)RecruitingNCT00872950
10National Registry for Egyptian Pediatric Neuromuscular DiseasesRecruitingNCT02124616
11Expanded Access Study of Firdapse® (Amifampridine Phosphate, 3,4 Diaminopyridine Phosphate) in Lambert-Eaton Myasthenic Syndrome (LEMS), Congenital Myasthenic Syndrome (CMS), or Downbeat Nystagmus PatientsAvailableNCT02189720
12Treatment of Lambert-Eaton Syndrome With 3,4 DAPAvailableNCT00704925
13Treatment of Lambert-Eaton Syndrome With 3,4 DiaminopyridineAvailableNCT00994916
143,4-Diaminopyridine for Lambert-Eaton Myasthenic Syndrome (LEMS) and Congenital Myasthenia (CM)AvailableNCT02012933
15Use Of 3,4-Diaminopyridine (3,4-DAP) In The Treatment Of Lambert Eaton Myasthenic SyndromeAvailableNCT01373333
16Treatment Use of 3,4-DiaminopyridineAvailableNCT01765140
17Controlled Trial of 3,4-Diaminopyridine (3-4DAP) in Lambert-Eaton Myasthenic Syndrome (LEMS)Enrolling by invitationNCT02090725
18Treatment of Lambert-Eaton Myasthenic Syndrome (LEMS) With 3, 4 DAPNo longer availableNCT01378546

Search NIH Clinical Center for Lambert-Eaton Myasthenic Syndrome


Cochrane evidence based reviews: Lambert-Eaton Myasthenic Syndrome

Genetic Tests for Lambert-Eaton Myasthenic Syndrome

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Anatomical Context for Lambert-Eaton Myasthenic Syndrome

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MalaCards organs/tissues related to Lambert-Eaton Myasthenic Syndrome:

33
Lung, Prostate, T cells, B cells, Pituitary, Testes, Breast

Animal Models for Lambert-Eaton Myasthenic Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Lambert-Eaton Myasthenic Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.5CACNA1A, CACNA1B, CACNB2, MUSK, SOX2, SOX3
2MP:00053867.4CACNA1A, CACNA1B, MUSK, SOX2, SOX3, SYT2
3MP:00053787.1CACNA1A, CACNA1B, CACNB2, MUSK, SOX2, SOX3
4MP:00053767.1CACNA1A, CACNA1B, CACNB2, MUSK, SOX2, SOX3
5MP:00107686.7CACNA1A, CACNA1B, CACNB2, ERC1, MUSK, SOX2

Publications for Lambert-Eaton Myasthenic Syndrome

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Articles related to Lambert-Eaton Myasthenic Syndrome:

(show top 50)    (show all 365)
idTitleAuthorsYear
1
Synaptotagmin 2 mutations cause an autosomal-dominant form of lambert-eaton myasthenic syndrome and nonprogressive motor neuropathy. (25192047)
2014
2
Italian recommendations for Lambert-Eaton myasthenic syndrome (LEMS) management. (24481713)
2014
3
Lambert-Eaton myasthenic syndrome in a 13-year-old girl with Xp11.22-p11.23 duplication. (24461257)
2014
4
Surgery results in complete cure of Lambert-Eaton myasthenic syndrome in a patient with metastatic Merkel cell carcinoma. (24704152)
2014
5
Conjoint occurrence of GABAB receptor antibodies in Lambert-Eaton myasthenic syndrome with antibodies to the voltage gated calcium channel. (24929678)
2014
6
Antibodies to active zone protein ERC1 in Lambert-Eaton myasthenic syndrome. (23583364)
2013
7
Large granular lymphocytic leukemia associated with Lambert-Eaton Myasthenic Syndrome: A case report. (24371773)
2013
8
Lambert-Eaton myasthenic syndrome following H1N1-influenza vaccination: a case report. (22571392)
2012
9
Lambert-Eaton myasthenic syndrome in brief. (21678709)
2011
10
Unusual paraneoplastic syndromes of breast carcinoma: a combination of cerebellar degeneration and Lambert-Eaton Myasthenic Syndrome. (19005633)
2011
11
Lambert-Eaton myasthenic syndrome as a cause of persistent neuromuscular weakness after a mediastinoscopic biopsy -A case report-. (20651998)
2010
12
Neuromuscular paraneoplastic syndromes: the Lambert-Eaton myasthenic syndrome. (20836646)
2010
13
Surgical correction of strabismus in Lambert-Eaton myasthenic syndrome: case reports. (19347132)
2009
14
Favorable response to rituximab in a patient with anti-VGCC-positive Lambert-Eaton myasthenic syndrome and cerebellar dysfunction. (19609921)
2009
15
Lambert-eaton myasthenic syndrome. (19210909)
2009
16
The potential use of ephedrine in Lambert-Eaton myasthenic syndrome : clinical and electrophysiological evaluation. (18535871)
2008
17
Lambert-Eaton myasthenic syndrome with pure ocular weakness. (17515551)
2007
18
Antibodies to acetylcholine receptors in patients with different clinical forms of myasthenia and Lambert-Eaton myasthenic syndrome. (17187204)
2007
19
A case of small cell carcinoma of the lung associated with paraneoplastic cerebellar degeneration and Lambert-Eaton myasthenic syndrome]. (16482925)
2006
20
Associated autoimmune diseases in patients with the Lambert-Eaton myasthenic syndrome and their families. (15503107)
2004
21
Treatment for Lambert-Eaton myasthenic syndrome. (12804456)
2003
22
High innate production of interleukin-10 and tumor necrosis factor-alpha contributes to susceptibility for non-paraneoplastic Lambert-Eaton myasthenic syndrome. (12864989)
2003
23
Seronegative Lambert-Eaton myasthenic syndrome: study of 110 Japanese patients. (12473768)
2002
24
Lambert-Eaton Myasthenic Syndrome. (11180749)
2001
25
Tonic pupils in Lambert-Eaton myasthenic syndrome. (11353435)
2001
26
The Lambert-Eaton myasthenic syndrome. (11269225)
2001
27
A randomized trial of 3,4-diaminopyridine in Lambert-Eaton myasthenic syndrome. (10680790)
2000
28
Decay of postexercise augmentation in the Lambert-Eaton myasthenic syndrome: effect of cooling. (9566398)
1998
29
Passive transfer of Lambert-Eaton myasthenic syndrome induces dihydropyridine sensitivity of ICa in mouse motor nerve terminals. (9744921)
1998
30
Acetylcholine receptor antibodies in the Lambert-Eaton myasthenic syndrome. (9484374)
1998
31
Differential effect of Lambert-Eaton myasthenic syndrome immunoglobulin on cloned neuronal voltage-gated calcium channels. (9668315)
1998
32
The role of autoantibodies in Lambert-Eaton myasthenic syndrome. (9668304)
1998
33
Single-fiber electromyography improvement with 3,4-diaminopyridine in Lambert-Eaton myasthenic syndrome. (9655139)
1998
34
A case of Addison's disease associated with the Lambert-Eaton myasthenic syndrome. (9294781)
1997
35
Lambert-Eaton myasthenic syndrome: clinical diagnosis, immune-mediated mechanisms, and update on therapies. (8968218)
1995
36
Lambert-Eaton myasthenic syndrome (LEMS) in association with lymphoproliferative disorders. (7783761)
1995
37
Lambert-Eaton myasthenic syndrome: pathogenesis and treatment. (7984825)
1994
38
Lambert-Eaton myasthenic syndrome in small cell lung cancer: nursing implications. (8047466)
1994
39
A Lambert-Eaton myasthenic syndrome antigen associated with presynaptic calcium channels. (8395427)
1993
40
Neuronal calcium channels as target for Lambert-Eaton myasthenic syndrome autoantibodies. (8395151)
1993
41
Serum and plasma from patients with Lambert-Eaton Myasthenic Syndrome reduce depolarization-dependent uptake of 45Ca2+ into rat cortical synaptosomes. (1814548)
1991
42
Type 2 fiber predominance in Lambert-Eaton myasthenic syndrome. (1922168)
1991
43
Effects of botulinum neurotoxin and Lambert-Eaton myasthenic syndrome IgG at mouse nerve terminals. (2550027)
1989
44
The effect of Lambert-Eaton myasthenic syndrome antibody on slow action potentials in mouse cardiac ventricle. (2907138)
1988
45
Lambert-Eaton myasthenic syndrome: the lack of short-term in vitro effects of serum factors on neuromuscular transmission. (2848093)
1988
46
Lambert-Eaton myasthenic syndrome IgG depletes presynaptic membrane active zone particles by antigenic modulation. (2853605)
1988
47
Lambert-Eaton myasthenic syndrome: evidence for calcium channel blockade. (2446555)
1987
48
Antibodies to brain proteins in a patient with subacute cerebellar degeneration and Lambert-Eaton myasthenic syndrome. (3686524)
1987
49
Immunoglobulins of Lambert-Eaton myasthenic syndrome inhibit rat pituitary hormone release. (3122645)
1987
50
Lambert-Eaton myasthenic syndrome IgG: early morphologic effects and immunolocalization at the motor endplate. (3479929)
1987

Variations for Lambert-Eaton Myasthenic Syndrome

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Expression for genes affiliated with Lambert-Eaton Myasthenic Syndrome

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Search GEO for disease gene expression data for Lambert-Eaton Myasthenic Syndrome.

Pathways for genes affiliated with Lambert-Eaton Myasthenic Syndrome

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GO Terms for genes affiliated with Lambert-Eaton Myasthenic Syndrome

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Cellular components related to Lambert-Eaton Myasthenic Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated calcium channel complexGO:00058918.7CACNA1A, CACNA1B, CACNB2

Biological processes related to Lambert-Eaton Myasthenic Syndrome according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1pituitary gland developmentGO:00219839.8SOX2, SOX3
2neuromuscular junction developmentGO:00075289.8CACNB2, MUSK
3receptor clusteringGO:00431139.7CACNA1A, MUSK
4negative regulation of neuron differentiationGO:00456659.7SOX2, SOX3
5regulation of calcium ion-dependent exocytosisGO:00171589.4CACNA1A, SYT2
6membrane depolarization during action potentialGO:00860109.4CACNA1A, CACNA1B
7membrane depolarizationGO:00518999.3CACNA1A, CACNA1B
8calcium ion-dependent exocytosis of neurotransmitterGO:00487919.2CACNA1A, SYT2
9response to painGO:00482659.1CACNA1A, CACNA1B
10calcium ion importGO:00705099.0CACNA1A, CACNA1B, CACNB2
11calcium ion transmembrane transportGO:00705888.4CACNA1A, CACNA1B, CACNB2

Molecular functions related to Lambert-Eaton Myasthenic Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated calcium channel activityGO:00052458.7CACNA1A, CACNA1B, CACNB2
2high voltage-gated calcium channel activityGO:00083318.4CACNA1A, CACNA1B, CACNB2

Sources for Lambert-Eaton Myasthenic Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet