MCID: LMB002
MIFTS: 47

Lambert-Eaton Myasthenic Syndrome malady

Rare diseases, Neuronal diseases categories

Aliases & Classifications for Lambert-Eaton Myasthenic Syndrome

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 42NINDS, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 33MeSH, 27ICD9CM, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
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Lambert-Eaton Myasthenic Syndrome, Aliases & Descriptions:

Name: Lambert-Eaton Myasthenic Syndrome 9 41 42 11 43 47 60
Lems 9 41
Myasthenic-Myopathic Syndrome of Lambert-Eaton 41
Myasthenic Syndrome of Lambert-Eaton 41
Lambert Eaton Myasthenic Syndrome 41
 
Lambert-Eaton Syndrome 9
Eaton Lambert Syndrome 41
Lambert Eaton Syndrome 41
Eaton-Lambert Syndrome 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
lambert-eaton myasthenic syndrome:
Inheritance: Not applicable; Prevalence: <1/1000000 (Netherlands),1-9/100000 (Europe),1-9/1000000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy


External Ids:

Disease Ontology9 DOID:0050214
MeSH33 D015624
ICD9CM27 358.1
Orphanet47 43393
MESH via Orphanet34 D015624
ICD10 via Orphanet26 G73.1
UMLS via Orphanet61 C0022972
ICD1025 G73.1

Summaries for Lambert-Eaton Myasthenic Syndrome

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NINDS:42 Lambert-Eaton myasthenic syndrome (LEMS) is a disorder of the neuromuscular junction-the site where nerve cells meet muscle cells and help activate the muscles. It is caused by a disruption of electrical impulses between these nerve and muscle cells. LEMS is an autoimmune condition; in such disorders the immune system, which normally protects the body from foreign organisms, mistakenly attacks the body's own tissues. The disruption of electrical impulses is associated with antibodies produced as a consequence of this autoimmunity. Symptoms include muscle weakness, a tingling sensation in the affected areas, fatigue, and dry mouth. LEMS is closely associated with cancer, in particular small cell lung cancer. More than half the individuals diagnosed with LEMS also develop small cell lung cancer. LEMS may appear up to 3 years before cancer is diagnosed.

MalaCards based summary: Lambert-Eaton Myasthenic Syndrome, also known as lems, is related to lambert syndrome and myasthenia gravis. An important gene associated with Lambert-Eaton Myasthenic Syndrome is CACNB2 (calcium channel, voltage-dependent, beta 2 subunit), and among its related pathways are ADP signalling through P2Y purinoceptor 12 and Integration of energy metabolism. The compounds nimodipine and nitrendipine have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and cerebellum, and related mouse phenotypes are respiratory system and craniofacial.

Disease Ontology:9 A neuromuscular junction disease that results from an abnormality of acetylcholine (ach) release at the neuromuscular junction. it results from an autoimmune attack against voltage-gated calcium channels (vgcc) on the presynaptic motor nerve terminal.

NIH Rare Diseases:41 Lambert eaton myasthenic syndrome (lems) is a disorder of the neuromuscular junction. the neuromuscular junction is the site where nerve cells meet muscle cells and help activate the muscles. this syndrome occurs when antibodies interfere with electrical impulses between the nerve and muscle cells. it may be associated with other autoimmune diseases, or more commonly coincide with or precede a diagnosis of cancer such as small cell lung cancer. symptoms may include muscle weakness, a tingling sensation in the affected areas, fatigue, and dry mouth. treatment of a underlying disorder or cancer is the first priority of treatment. last updated: 4/22/2011

Wikipedia:63 Lambert?Eaton myasthenic syndrome (LEMS, also Lambert?Eaton syndrome, or Eaton?Lambert syndrome) is a... more...

Related Diseases for Lambert-Eaton Myasthenic Syndrome

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Graphical network of the top 20 diseases related to Lambert-Eaton Myasthenic Syndrome:



Diseases related to lambert-eaton myasthenic syndrome

Symptoms for Lambert-Eaton Myasthenic Syndrome

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Drugs & Therapeutics for Lambert-Eaton Myasthenic Syndrome

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Drug clinical trials:

Search ClinicalTrials for Lambert-Eaton Myasthenic Syndrome

Search NIH Clinical Center for Lambert-Eaton Myasthenic Syndrome

Genetic Tests for Lambert-Eaton Myasthenic Syndrome

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Anatomical Context for Lambert-Eaton Myasthenic Syndrome

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MalaCards organs/tissues related to Lambert-Eaton Myasthenic Syndrome:

31
Lung, Brain, Cerebellum, Skeletal muscle, Breast, Prostate, Testes, T cells, B cells, Pituitary

Animal Models for Lambert-Eaton Myasthenic Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Lambert-Eaton Myasthenic Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.8CACNA1A, MUSK, SOX2
2MP:00053828.7SOX3, SOX2, CACNB2
3MP:00107718.4CACNA1B, CACNA1A, MUSK, SOX2
4MP:00030128.2SOX3, SOX2, CACNA1A
5MP:00053847.9CACNA1A, MUSK, SOX2, SOX3
6MP:00053867.6SOX3, SOX2, MUSK, CACNA1A, CACNA1B
7MP:00036317.3CACNA1B, CACNA1A, CACNB2, MUSK, SOX2, SOX3
8MP:00053787.3SOX3, SOX2, MUSK, CACNB2, CACNA1A, CACNA1B
9MP:00053767.3SOX3, SOX2, MUSK, CACNB2, CACNA1A, CACNA1B
10MP:00107687.3SOX3, SOX2, MUSK, CACNB2, CACNA1A, CACNA1B

Publications for Lambert-Eaton Myasthenic Syndrome

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Articles related to Lambert-Eaton Myasthenic Syndrome:

(show top 50)    (show all 354)
idTitleAuthorsYear
1
Synaptotagmin 2 mutations cause an autosomal-dominant form of lambert-eaton myasthenic syndrome and nonprogressive motor neuropathy. (25192047)
2014
2
Italian recommendations for Lambert-Eaton myasthenic syndrome (LEMS) management. (24481713)
2014
3
Lambert-Eaton myasthenic syndrome in a 13-year-old girl with Xp11.22-p11.23 duplication. (24461257)
2014
4
Surgery results in complete cure of Lambert-Eaton myasthenic syndrome in a patient with metastatic Merkel cell carcinoma. (24704152)
2014
5
Conjoint occurrence of GABAB receptor antibodies in Lambert-Eaton myasthenic syndrome with antibodies to the voltage gated calcium channel. (24929678)
2014
6
Antibodies to active zone protein ERC1 in Lambert-Eaton myasthenic syndrome. (23583364)
2013
7
Large granular lymphocytic leukemia associated with Lambert-Eaton Myasthenic Syndrome: A case report. (24371773)
2013
8
Lambert-Eaton myasthenic syndrome following H1N1-influenza vaccination: a case report. (22571392)
2012
9
Lambert-Eaton myasthenic syndrome in brief. (21678709)
2011
10
Unusual paraneoplastic syndromes of breast carcinoma: a combination of cerebellar degeneration and Lambert-Eaton Myasthenic Syndrome. (19005633)
2011
11
Lambert-Eaton myasthenic syndrome as a cause of persistent neuromuscular weakness after a mediastinoscopic biopsy -A case report-. (20651998)
2010
12
Neuromuscular paraneoplastic syndromes: the Lambert-Eaton myasthenic syndrome. (20836646)
2010
13
Favorable response to rituximab in a patient with anti-VGCC-positive Lambert-Eaton myasthenic syndrome and cerebellar dysfunction. (19609921)
2009
14
Lambert-eaton myasthenic syndrome. (19210909)
2009
15
The potential use of ephedrine in Lambert-Eaton myasthenic syndrome : clinical and electrophysiological evaluation. (18535871)
2008
16
Cerebellar ataxia in non-paraneoplastic Lambert-Eaton myasthenic syndrome. (18374949)
2008
17
Lambert-Eaton myasthenic syndrome with pure ocular weakness. (17515551)
2007
18
Antibodies to acetylcholine receptors in patients with different clinical forms of myasthenia and Lambert-Eaton myasthenic syndrome. (17187204)
2007
19
A case of small cell carcinoma of the lung associated with paraneoplastic cerebellar degeneration and Lambert-Eaton myasthenic syndrome]. (16482925)
2006
20
Associated autoimmune diseases in patients with the Lambert-Eaton myasthenic syndrome and their families. (15503107)
2004
21
Treatment for Lambert-Eaton myasthenic syndrome. (12804456)
2003
22
High innate production of interleukin-10 and tumor necrosis factor-alpha contributes to susceptibility for non-paraneoplastic Lambert-Eaton myasthenic syndrome. (12864989)
2003
23
Seronegative Lambert-Eaton myasthenic syndrome: study of 110 Japanese patients. (12473768)
2002
24
Lambert-Eaton Myasthenic Syndrome. (11180749)
2001
25
Tonic pupils in Lambert-Eaton myasthenic syndrome. (11353435)
2001
26
The Lambert-Eaton myasthenic syndrome. (11269225)
2001
27
A randomized trial of 3,4-diaminopyridine in Lambert-Eaton myasthenic syndrome. (10680790)
2000
28
Decay of postexercise augmentation in the Lambert-Eaton myasthenic syndrome: effect of cooling. (9566398)
1998
29
Passive transfer of Lambert-Eaton myasthenic syndrome induces dihydropyridine sensitivity of ICa in mouse motor nerve terminals. (9744921)
1998
30
Acetylcholine receptor antibodies in the Lambert-Eaton myasthenic syndrome. (9484374)
1998
31
Differential effect of Lambert-Eaton myasthenic syndrome immunoglobulin on cloned neuronal voltage-gated calcium channels. (9668315)
1998
32
The role of autoantibodies in Lambert-Eaton myasthenic syndrome. (9668304)
1998
33
Single-fiber electromyography improvement with 3,4-diaminopyridine in Lambert-Eaton myasthenic syndrome. (9655139)
1998
34
A case of Addison's disease associated with the Lambert-Eaton myasthenic syndrome. (9294781)
1997
35
Lambert-Eaton myasthenic syndrome: clinical diagnosis, immune-mediated mechanisms, and update on therapies. (8968218)
1995
36
Lambert-Eaton myasthenic syndrome (LEMS) in association with lymphoproliferative disorders. (7783761)
1995
37
Lambert-Eaton myasthenic syndrome: pathogenesis and treatment. (7984825)
1994
38
Lambert-Eaton myasthenic syndrome in small cell lung cancer: nursing implications. (8047466)
1994
39
A Lambert-Eaton myasthenic syndrome antigen associated with presynaptic calcium channels. (8395427)
1993
40
Neuronal calcium channels as target for Lambert-Eaton myasthenic syndrome autoantibodies. (8395151)
1993
41
Serum and plasma from patients with Lambert-Eaton Myasthenic Syndrome reduce depolarization-dependent uptake of 45Ca2+ into rat cortical synaptosomes. (1814548)
1991
42
Type 2 fiber predominance in Lambert-Eaton myasthenic syndrome. (1922168)
1991
43
Effects of botulinum neurotoxin and Lambert-Eaton myasthenic syndrome IgG at mouse nerve terminals. (2550027)
1989
44
The effect of Lambert-Eaton myasthenic syndrome antibody on slow action potentials in mouse cardiac ventricle. (2907138)
1988
45
Lambert-Eaton myasthenic syndrome: the lack of short-term in vitro effects of serum factors on neuromuscular transmission. (2848093)
1988
46
Lambert-Eaton myasthenic syndrome IgG depletes presynaptic membrane active zone particles by antigenic modulation. (2853605)
1988
47
Lambert-Eaton myasthenic syndrome: evidence for calcium channel blockade. (2446555)
1987
48
Antibodies to brain proteins in a patient with subacute cerebellar degeneration and Lambert-Eaton myasthenic syndrome. (3686524)
1987
49
Immunoglobulins of Lambert-Eaton myasthenic syndrome inhibit rat pituitary hormone release. (3122645)
1987
50
Lambert-Eaton myasthenic syndrome IgG: early morphologic effects and immunolocalization at the motor endplate. (3479929)
1987

Variations for Lambert-Eaton Myasthenic Syndrome

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Expression for genes affiliated with Lambert-Eaton Myasthenic Syndrome

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Search GEO for disease gene expression data for Lambert-Eaton Myasthenic Syndrome.

Pathways for genes affiliated with Lambert-Eaton Myasthenic Syndrome

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Pathways related to Lambert-Eaton Myasthenic Syndrome according to GeneCards Suite gene sharing:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6CACNA1B, CACNB2
2
Show member pathways
9.4CACNA1A, CACNB2
3
Show member pathways
9.4CACNA1B, CACNA1A
49.4CACNA1B, CACNA1A
59.4CACNA1B, CACNA1A
69.4CACNA1B, CACNA1A
7
Show member pathways
9.4CACNA1B, CACNA1A
89.4CACNA1A, CACNA1B
9
Show member pathways
Calcium Regulation in the Cardiac Cell36
9.4CACNA1B, CACNA1A
10
Show member pathways
Synaptic Vesicle Pathway36
9.4CACNA1A, CACNA1B
11
Show member pathways
9.0CACNA1B, CACNA1A, CACNB2
12
Show member pathways
9.0CACNB2, CACNA1A, CACNA1B
13
Show member pathways
9.0CACNA1B, CACNA1A, CACNB2
14
Show member pathways
9.0CACNA1B, CACNA1A, CACNB2
15
Show member pathways
9.0CACNB2, CACNA1A, CACNA1B
16
Show member pathways
9.0CACNB2, CACNA1A, CACNA1B
17
Show member pathways
9.0CACNA1B, CACNA1A, CACNB2
18
Show member pathways
Development Ligand independent activation of ESR1 and ESR258
9.0CACNB2, CACNA1A, CACNA1B
19
Show member pathways
9.0CACNA1B, CACNA1A, CACNB2
209.0CACNB2, CACNA1A, CACNA1B
219.0CACNA1B, CACNA1A, CACNB2
22
Show member pathways
MAPK signaling pathway36
9.0CACNA1B, CACNA1A, CACNB2
239.0CACNB2, CACNA1A, CACNA1B
24
Show member pathways
9.0CACNA1B, CACNA1A, CACNB2
25
Show member pathways
9.0CACNB2, CACNA1A, CACNA1B
269.0CACNA1B, CACNA1A, CACNB2
27
Show member pathways
9.0CACNB2, CACNA1A, CACNA1B
28
Show member pathways
8.5MUSK, CACNB2, CACNA1A, CACNA1B
29
Show member pathways
8.5MUSK, CACNB2, CACNA1A, CACNA1B
30
Show member pathways
8.5CACNA1B, CACNA1A, CACNB2, MUSK
31
Show member pathways
7.1CACNA1B, SOX3, SOX2, MUSK, CACNB2, CACNA1A

Compounds for genes affiliated with Lambert-Eaton Myasthenic Syndrome

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Compounds related to Lambert-Eaton Myasthenic Syndrome according to GeneCards Suite gene sharing:

(show all 18)
idCompoundScoreTop Affiliating Genes
1nimodipine43 28 1211.9CACNA1B, CACNB2
2nitrendipine43 49 28 1212.8CACNA1B, CACNB2
3mibefradil43 28 1211.8CACNB2, CACNA1B
4amlodipine43 49 24 1212.8CACNA1B, CACNB2
5nicardipine43 28 1211.7CACNA1B, CACNB2
6omega-conotoxin mviic289.7CACNA1B, CACNA1A
7(+-)-bay k 8644599.7CACNA1A, CACNA1B
8nnc 55-0396 dihydrochloride599.7CACNA1A, CACNA1B
9mibefradil dihydrochloride599.7CACNA1A, CACNA1B
10omega-conotoxin gvia59 2810.7CACNA1A, CACNA1B
11pregabalin59 43 1211.7CACNA1A, CACNA1B
12ryanodine43 28 5911.5CACNA1B, MUSK
13nicotine43 28 49 1212.5CACNA1B, MUSK
14nifedipine43 28 49 1212.3CACNA1B, CACNB2
15verapamil43 28 49 24 1213.3CACNA1B, CACNA1A, CACNB2
16acetylcholine43 49 28 24 1213.1CACNA1B, CACNA1A, MUSK
17potassium43 24 1210.9MUSK, CACNA1A, CACNA1B
18calcium43 49 24 1211.4MUSK, CACNB2, CACNA1A, CACNA1B

GO Terms for genes affiliated with Lambert-Eaton Myasthenic Syndrome

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Cellular components related to Lambert-Eaton Myasthenic Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated calcium channel complexGO:00058919.0CACNA1B, CACNA1A, CACNB2

Biological processes related to Lambert-Eaton Myasthenic Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membrane depolarizationGO:00518999.5CACNA1B, CACNA1A
2neuromuscular junction developmentGO:00075289.4MUSK, CACNB2
3pituitary gland developmentGO:00219839.1SOX2, SOX3
4negative regulation of neuron differentiationGO:00456659.1SOX2, SOX3
5synaptic transmissionGO:00072688.7CACNA1B, CACNA1A, CACNB2

Molecular functions related to Lambert-Eaton Myasthenic Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1high voltage-gated calcium channel activityGO:00083319.1CACNA1A, CACNB2
2voltage-gated calcium channel activityGO:00052458.9CACNA1B, CACNA1A, CACNB2
3protein bindingGO:00055157.9MUSK, CACNB2, CACNA1A, CACNA1B, SOX2

Products for genes affiliated with Lambert-Eaton Myasthenic Syndrome

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Sources for Lambert-Eaton Myasthenic Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet