MCID: LND001
MIFTS: 33

Landau-Kleffner Syndrome malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Landau-Kleffner Syndrome

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 46NINDS, 12DISEASES, 51Orphanet, 36MeSH, 65UMLS, 27ICD10, 42NCIt, 59SNOMED-CT, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Landau-Kleffner Syndrome:

Name: Landau-Kleffner Syndrome 10 45 46 12 51 36 65
Acquired Epileptic Aphasia 10 45 51
Acquired Epileptiform Aphasia 45 46
 
Lks 45 51
Acquired Aphasia with Convulsive Disorder 45

Characteristics:

Orphanet epidemiological data:

51
landau-kleffner syndrome:
Inheritance: Autosomal dominant; Age of onset: Childhood; Age of death: any age

Classifications:



External Ids:

Disease Ontology10 DOID:2538
ICD1027 G40.8
MeSH36 D018887
NCIt42 C84806
Orphanet51 98818
MESH via Orphanet37 D018887
UMLS via Orphanet66 C0282512
UMLS65 C0282512

Summaries for Landau-Kleffner Syndrome

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NIH Rare Diseases:45 Landau-kleffner syndrome (lks) is a rare, childhood neurological disorder characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electro-encephalogram (eeg). the disorder usually occurs in children between age 2 and 8. typically, children with lks develop normally but then lose their language skills for no apparent reason. while many of the affected individuals have seizures, some do not. the disorder is difficult to diagnose and may be misdiagnosed as autism, pervasive developmental disorder, hearing impairment, learning disability, auditory/verbal processing disorder, attention deficit disorder, intellectual disability, childhood schizophrenia, or emotional/behavioral problems. treatment for lks usually consists of medications, such as anticonvulsants and corticosteroids, and speech therapy, which should be started promptly. the prognosis varies. some children may have a permanent language disorder, while others may regain much of their language abilities (although it may take months or years). last updated: 4/13/2015

MalaCards based summary: Landau-Kleffner Syndrome, also known as acquired epileptic aphasia, is related to kashin-beck disease and epilepsy, focal, with speech disorder and with or without mental retardation. An important gene associated with Landau-Kleffner Syndrome is GRIN2A (Glutamate Ionotropic Receptor NMDA Type Subunit 2A). Affiliated tissues include brain, t cells and breast, and related mouse phenotype integument.

NINDS:46 Landau-Kleffner syndrome (LKS) is a rare, childhood neurological disorder characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electro-encephalogram (EEG). LKS affects the parts of the brain that control comprehension and speech. The disorder usually occurs in children between the ages of 5 and 7 years. Typically, children with LKS develop normally but then lose their language skills for no apparent reason. While many of the affected individuals have seizures, some do not. The disorder is difficult to diagnose and may be misdiagnosed as autism, pervasive developmental disorder, hearing impairment, learning disability, auditory/verbal processing disorder, attention deficit disorder, childhood schizophrenia, or emotional/behavioral problems.

Wikipedia:68 Landau–Kleffner syndrome (LKS)—also called infantile acquired aphasia, acquired epileptic aphasia or... more...

Related Diseases for Landau-Kleffner Syndrome

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Graphical network of the top 20 diseases related to Landau-Kleffner Syndrome:



Diseases related to landau-kleffner syndrome

Symptoms for Landau-Kleffner Syndrome

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Drugs & Therapeutics for Landau-Kleffner Syndrome

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Interventional clinical trials:

idNameStatusNCT IDPhase
1The Rolandic Epilepsy/ESES/Landau-Kleffner Syndrome and Correlation With Language Impairment StudyCompletedNCT01335425
2Genetic Basis of Idiopathic Focal Epilepsies With Cognitif DeficitsNot yet recruitingNCT00851331

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Cochrane evidence based reviews: landau-kleffner syndrome

Genetic Tests for Landau-Kleffner Syndrome

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Anatomical Context for Landau-Kleffner Syndrome

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MalaCards organs/tissues related to Landau-Kleffner Syndrome:

33
Brain, T cells, Breast, Bone, Pituitary, Endothelial, Testes

Animal Models for Landau-Kleffner Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Landau-Kleffner Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.7GRIN2A, ITSN2, NDUFS4, POMC

Publications for Landau-Kleffner Syndrome

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Articles related to Landau-Kleffner Syndrome:

(show top 50)    (show all 172)
idTitleAuthorsYear
1
Renal cell carcinoma to haemangioblastoma metastasis: a rare manifestation of Von Hippel-Lindau syndrome. (25088480)
2015
2
Pediatric Experience in Surgical Treatment of Acquired Esotropia Associated With High Myopia. (26053212)
2015
3
Trypanosoma cruzi evades the protective role of interferon-gamma-signaling in parasite-infected cells. (25340519)
2014
4
A rare case of primary nodal hemangioendothelioma. (24260072)
2013
5
A functional and genetic analysis of SOD2 promoter variants and their contribution to age-related hearing loss. (23500038)
2013
6
Survivin in adrenocortical tumors - pathophysiological implications and therapeutic potential. (23143666)
2013
7
Enoxaparin-associated atraumatic compartment syndrome of the calf. (21559748)
2012
8
Chronic hepatitis E virus infection in a patient with leukemia and elevated transaminases: a case report. (23031738)
2012
9
Projected numbers of people with movement disorders in the years 2030 and 2050: implications for sub-Saharan Africa, using essential tremor and Parkinson's disease in Tanzania as an example. (22791221)
2012
10
RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis. (22709525)
2012
11
Radiofrequency sacral rhizotomy for the management of intolerable neurogenic bladder in spinal cord injured patients. (22639745)
2012
12
Expression and role of HMGA1 in renal cell carcinoma. (22503056)
2012
13
Influence of fetal stabilization on postnatal status of patients with congenital diaphragmatic hernia. (20842386)
2011
14
Diffuse skeletal muscles uptake of [18F] fluorodeoxyglucose on positron emission tomography in primary muscle peripheral T-cell lymphoma. (21921389)
2011
15
Homocysteine induces caspase activation by endoplasmic reticulum stress in platelets from type 2 diabetics and healthy donors. (20216988)
2010
16
Mutational analysis of RUNX2 gene in Chinese patients with cleidocranial dysplasia. (20702542)
2010
17
Intermolecular cross-talk between NTR1 and NTR2 neurotensin receptor promotes intracellular sequestration and functional inhibition of NTR1 receptors. (19968961)
2010
18
Overexpression of matrix metalloproteinase 11 in human gastric carcinoma and its clinicopathologic significance. (20060156)
2010
19
Biochemical analysis of PKR activation by PACT. (19580324)
2009
20
Severe skin necrosis after breast reconstruction with a transverse rectus abdominis musculocutaneous flap in methylenetetrahydrofolate reductase deficiency. (18774766)
2009
21
Functional characterization of genetic variation in the Frizzled 1 (FZD1) promoter and association with bone phenotypes: more to the LRP5 story? (18715140)
2009
22
Thirty-two novel HLA-A alleles identified during intermediate resolution testing. (18069934)
2008
23
Paraneoplastic polymyositis associated with crescentic glomerulonephritis. (18925535)
2008
24
Cauda equina syndrome versus saddle embolism. (18765019)
2008
25
The immunological response of Thai infants to haemophilus influenzae type B polysaccharide-tetanus conjugate vaccine co-administered in the same syringe with locally produced diphtheria-tetanus-pertussis vaccine. (17710973)
2007
26
The mouse C/EBPdelta gene promoter is regulated by STAT3 and Sp1 transcriptional activators, chromatin remodeling and c-Myc repression. (17471507)
2007
27
Successful pancreatectomy with en-bloc resection of the celiac artery and portal vein for pancreatic endocrine carcinoma. (17629086)
2007
28
Reactive oxygen species and antioxidants relationship in the internal spermatic vein blood of infertile men with varicocele. (16763721)
2006
29
Natriuretic peptides and mortality after stroke. (15802631)
2005
30
Oral vitamin B12 therapy in vitamin B12 deficiency. (14984828)
2004
31
Treatment of cystoid macular edema related to retinitis pigmentosa with intravitreal triamcinolone acetonide: case report. (15180250)
2003
32
One of two human lactoferrin variants exhibits increased antibacterial and transcriptional activation activities and is associated with localized juvenile periodontitis. (14573629)
2003
33
A single amino acid difference between human and monkey interleukin (IL)-1beta dictates effective binding to soluble type II IL-1 receptor. (12356774)
2002
34
Histopathological analysis of Leri-Weill dyschondrosteosis: disordered growth plate. (11677662)
2001
35
Current management of primary pulmonary hypertension. (11708765)
2001
36
Parasympathetic dysautonomia precedes left ventricular systolic dysfunction in Chagas disease. (11174350)
2001
37
Estrogen receptor beta acts as a dominant regulator of estrogen signaling. (11042684)
2000
38
Successful pregnancy in a case of pituitary dwarfism complicated by diabetes insipidus and primary amenorrhea. (10949242)
2000
39
Relationship between productive HIV-1 infection of macrophages and CCR5 utilization. (10562492)
1999
40
Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52). (8812487)
1996
41
Composition of human low density lipoprotein: effects of postprandial triglyceride-rich lipoproteins, lipoprotein lipase, hepatic lipase and cholesteryl ester transfer protein. (8457249)
1993
42
Peripheral monocyte culture supernatants of menopausal women can induce bone resorption: involvement of cytokines. (8263153)
1993
43
Fine-needle aspiration biopsy of seminoma and dysgerminoma: cytologic, histologic, and electron microscopic correlations. (2159868)
1990
44
Recurrent endometrial stromal sarcoma resembling intravenous leiomyomatosis. (3653763)
1987
45
Extreme variant of septo-optic dysplasia. (3934619)
1985
46
Behavioural techniques in the management of aerophagia in patients with hiatus hernia. (6363680)
1983
47
Intestinal pseudo-obstruction. (6846996)
1983
48
Genetic relationship between paranoid personality disorder and the "schizophrenic spectrum" disorders. (7114313)
1982
49
Tricuspid atresia with special emphasis on cases with increased pulmonary blood flow. (4117484)
1972
50

Variations for Landau-Kleffner Syndrome

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Expression for genes affiliated with Landau-Kleffner Syndrome

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Search GEO for disease gene expression data for Landau-Kleffner Syndrome.

Pathways for genes affiliated with Landau-Kleffner Syndrome

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GO Terms for genes affiliated with Landau-Kleffner Syndrome

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Sources for Landau-Kleffner Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet