MCID: LNG004
MIFTS: 33

Langerhans Cell Sarcoma malady

Blood diseases, Cancer diseases categories

Summaries for Langerhans Cell Sarcoma

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Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A histiocytic and dendritic cell cancer that derives from the lymph nodes, derives from the skin, derives from the liver, derives from the spleen and derives from bones.

MalaCards: Langerhans Cell Sarcoma, also known as malignant langerhans cell sarcoma, is related to sarcoma and histiocytosis. An important gene associated with Langerhans Cell Sarcoma is CD207 (CD207 molecule, langerin). The compound mannose have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and spleen.

Wikipedia:63 Langerhans cell sarcoma is a form of malignant histiocytosis. It should not be confused with Langerhans... more...

Aliases & Classifications for Langerhans Cell Sarcoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
langerhans cell sarcoma:
Age of onset: Variable


Aliases & Descriptions:

langerhans cell sarcoma 8 42 10 48 60
malignant langerhans cell sarcoma 42


External Ids:

Disease Ontology8 DOID:7146
MeSH34 D054752
NCIt39 C6921
MESH via Orphanet35 D054752
SNOMED-CT56 128814006
SNOMED-CT via Orphanet57 128814006
ICD10 via Orphanet26 C96.4
UMLS via Orphanet61 C1260327

Related Diseases for Langerhans Cell Sarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Langerhans Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 15)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.2S100B, CD1A, CD207
2histiocytosis30.1S100B, CD1A, CD207
3leukemia10.4
4cervicitis10.3
5small cell sarcoma10.1
6chronic lymphocytic leukemia10.1
7gallbladder sarcoma10.1
8hairy cell leukemia10.1
9langerhans-cell histiocytosis10.1
10peritonitis10.1
11skin sarcoma10.1
12asthma10.0CD1A
13ependymoma10.0S100B
14mycosis fungoides10.0CD1A
15letterer-siwe disease10.0CD1A, CD207

Graphical network of diseases related to Langerhans Cell Sarcoma:



Diseases related to langerhans cell sarcoma

Clinical Features for Langerhans Cell Sarcoma

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Drugs & Therapeutics for Langerhans Cell Sarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Langerhans Cell Sarcoma

Search CenterWatch for Langerhans Cell Sarcoma

Genetic Tests for Langerhans Cell Sarcoma

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Anatomical Context for Langerhans Cell Sarcoma

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32MalaCards
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MalaCards organs/tissues related to Langerhans Cell Sarcoma:

32
Bone, Lung, Spleen, Lymph node, Myeloid, Skin, Liver

Animal Models for Langerhans Cell Sarcoma or affiliated genes

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Publications for Langerhans Cell Sarcoma

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50PubMed
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Articles related to Langerhans Cell Sarcoma:

(show all 38)
idTitleAuthorsYear
1
The genetics of interdigitating dendritic cell sarcoma share some changes with Langerhans cell histiocytosis in select cases. (24321462)
2014
2
Langerhans cell sarcoma: a case report. (23590692)
2013
3
Expression and anatomical distribution of TIM-containing molecules in Langerhans cell sarcoma. (23264111)
2013
4
Langerhans cell sarcoma: a case report and review of the literature. (23557341)
2013
5
Langerhans cell sarcoma in two young children: imaging findings on initial presentation and recurrence. (23690723)
2013
6
Langerhans cell sarcoma of the nasopharynx: a rare case. (24215052)
2013
7
Killing two birds with one stone: BRAF V600E inhibitor therapy for hairy cell leukemia and Langerhans/dendritic cell sarcoma. (23322213)
2013
8
Paraneoplastic disseminated lentigines heralding aggressive Langerhans cell sarcoma. (22992981)
2013
9
Primary cutaneous langerhans cell sarcoma: a report of four cases and review of the literature. (23051626)
2013
10
Unusual cutaneous Langerhans cell sarcoma without extracutaneous involvement. (23388086)
2013
11
Langerhans Cell Sarcoma Arising from Chronic Lymphocytic Lymphoma/Small Lymphocytic Leukemia: Lineage Analysis and BRAF V600E Mutation Study. (23923114)
2013
12
Langerhans Cell Sarcoma in a Chronic Myelogenous Leukemia Patient Undergoing Imatinib Mesylate Therapy: A Case Study and Review of the Literature. (24008437)
2013
13
Langerhans cell sarcoma in the cervical lymph node: a case report and literature review. (23207655)
2013
14
Coexistence of Langerhans cell histiocytosis, Rosai-Dorfman disease and splenic lymphoma with fatal outcome after rapid development of histiocytic sarcoma of the liver. (23043641)
2012
15
Langerhans/dendritic cell sarcoma arising from hairy cell leukemia: a rare phenomenon. (22234838)
2012
16
Langerhans cell sarcoma in a patient with hairy cell leukemia: common clonal origin indicated by identical immunoglobulin gene rearrangements. (22616604)
2012
17
Clonal relationship between langerhans cell histiocytosis and myeloid sarcoma. (22382895)
2012
18
Multifocal Langerhans cell sarcoma involving epidermis: a case report and review. (22889043)
2012
19
The characteristic expression of B7-associated proteins in Langerhans cell sarcoma. (22305414)
2012
20
The characteristics of FDG PET/CT imaging in pulmonary Langerhans cell sarcoma. (22475903)
2012
21
Langerhans cell sarcoma with an aberrant cytoplasmic CD3 expression. (23006414)
2012
22
Langerhans cell sarcoma of the cervical lymph node: a case report and literature review. (20554413)
2010
23
Langerhans cell sarcoma: Response to radiotherapy. (24376934)
2010
24
The Hammersmith Hospital hematopathology case of the month: myeloid sarcoma with Langerhans cell proliferation. (20536351)
2010
25
Chemotherapy for Langerhans cell sarcoma. (19337819)
2009
26
Langerhans cell sarcoma involving gallbladder and peritoneal lymph nodes: a case report. (18805873)
2009
27
Pulmonary histiocytic sarcoma mimicking pulmonary Langerhans cell histiocytosis in a young adult presenting with spontaneous pneumothorax: a potential diagnostic pitfall. (19562369)
2009
28
Primary cutaneous Langerhans cell sarcoma without Birbeck granules: indeterminate cell sarcoma? (18422973)
2008
29
ESHAP therapy effective in a patient with Langerhans cell sarcoma. (18415657)
2008
30
Langerhans cell sarcoma emanating from the upper arm skin: successful treatment by MAID regimen. (18274862)
2008
31
Fine needle aspiration cytology of Langerhans cell sarcoma. (18205629)
2008
32
Leukemic transformation of Langerhans cell sarcoma. (18360746)
2008
33
Cutaneous Langerhans cell sarcoma: a case report and review of the literature. (17321988)
2007
34
Langerhans cell sarcoma in a patient who underwent transplantation. (17659009)
2007
35
Langerhans cell sarcoma. (16456323)
2006
36
Langerhans cell sarcoma arising from Langerhans cell histiocytosis: a case report. (16778410)
2006
37
Pulmonary manifestation of a Langerhans cell sarcoma: case report and review of the literature. (16328350)
2006
38
CD56/NCAM-positive Langerhans cell sarcoma: a clinicopathologic study of 4 cases. (15914364)
2005

Genetic Variations for Langerhans Cell Sarcoma

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Expression for genes affiliated with Langerhans Cell Sarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Langerhans Cell Sarcoma

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Pathways for genes affiliated with Langerhans Cell Sarcoma

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Compounds for genes affiliated with Langerhans Cell Sarcoma

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44Novoseek
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Compounds related to Langerhans Cell Sarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mannose449.4LY75, CD207

GO Terms for genes affiliated with Langerhans Cell Sarcoma

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16Gene Ontology
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Biological processes related to Langerhans Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:0069559.3LY75, CD1A

Molecular functions related to Langerhans Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbohydrate bindingGO:0302469.4LY75, CD207

Products for genes affiliated with Langerhans Cell Sarcoma

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Sources for Langerhans Cell Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet