MCID: LNG004
MIFTS: 37

Langerhans Cell Sarcoma

Categories: Rare diseases, Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Langerhans Cell Sarcoma

MalaCards integrated aliases for Langerhans Cell Sarcoma:

Name: Langerhans Cell Sarcoma 12 50 56 42 14 69
Malignant Langerhans Cell Sarcoma 50

Characteristics:

Orphanet epidemiological data:

56
langerhans cell sarcoma
Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:7146
ICD10 33 C96.4
MeSH 42 D054752
NCIt 47 C6921
SNOMED-CT 64 128814006
Orphanet 56 ORPHA86897
MESH via Orphanet 43 D054752
UMLS via Orphanet 70 C1260327
ICD10 via Orphanet 34 C96.4
UMLS 69 C1260327

Summaries for Langerhans Cell Sarcoma

Disease Ontology : 12 A histiocytic and dendritic cell cancer that derives from the lymph nodes, derives from the skin, derives from the liver, derives from the spleen and derives from bones.

MalaCards based summary : Langerhans Cell Sarcoma, also known as malignant langerhans cell sarcoma, is related to dendritic cell tumor and sarcoma. An important gene associated with Langerhans Cell Sarcoma is CD207 (CD207 Molecule), and among its related pathways/superpathways are Immune response Lectin induced complement pathway and Complement and coagulation cascades. The drugs Busulfan and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone, spleen and lung.

Wikipedia : 72 Langerhans cell sarcoma is a form of malignant histiocytosis. It should not be confused with Langerhans... more...

Related Diseases for Langerhans Cell Sarcoma

Graphical network of the top 20 diseases related to Langerhans Cell Sarcoma:



Diseases related to Langerhans Cell Sarcoma

Symptoms & Phenotypes for Langerhans Cell Sarcoma

Drugs & Therapeutics for Langerhans Cell Sarcoma

Drugs for Langerhans Cell Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Busulfan Approved, Investigational Phase 2 55-98-1 2478
2
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
3
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
4
Melphalan Approved Phase 2 148-82-3 4053 460612
5
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
7
Lenalidomide Approved Phase 2 191732-72-6 216326
8
Everolimus Approved Phase 2 159351-69-6 6442177
9
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
10
Olaparib Approved Phase 2 763113-22-0 23725625
11
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
12 Alkylating Agents Phase 2
13 Antiemetics Phase 2
14 Anti-Inflammatory Agents Phase 2
15 Antilymphocyte Serum Phase 2
16 Antimetabolites Phase 2
17 Antimetabolites, Antineoplastic Phase 2
18 Antineoplastic Agents, Hormonal Phase 2
19 Antirheumatic Agents Phase 2
20 Autonomic Agents Phase 2
21 Gastrointestinal Agents Phase 2
22 glucocorticoids Phase 2
23 Hormone Antagonists Phase 2
24 Hormones Phase 2
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
26 Immunosuppressive Agents Phase 2
27 Methylprednisolone acetate Phase 2
28 Methylprednisolone Hemisuccinate Phase 2
29 Neuroprotective Agents Phase 2
30 Peripheral Nervous System Agents Phase 2
31 Prednisolone acetate Phase 2
32 Prednisolone hemisuccinate Phase 2
33 Prednisolone phosphate Phase 2
34 Protective Agents Phase 2
35 Angiogenesis Inhibitors Phase 2
36 Angiogenesis Modulating Agents Phase 2
37 Anti-Bacterial Agents Phase 2
38 Anti-Infective Agents Phase 2
39 Antibiotics, Antitubercular Phase 2
40 Antifungal Agents Phase 2
41 Poly(ADP-ribose) Polymerase Inhibitors Phase 2
42 tyrosine Nutraceutical Phase 2
43 Liver Extracts

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Umbilical Cord Blood for Stem Cell Transplantation in Treating Young Patients With Malignant or Nonmalignant Diseases Unknown status NCT00084695 Phase 2 busulfan;cyclophosphamide;fludarabine phosphate;melphalan;methylprednisolone
2 A Study of Lenalidomide for Adult Histiocyte Disorders Recruiting NCT02523040 Phase 2 Lenalidomide
3 Pediatric MATCH: Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders Recruiting NCT03155620 Phase 2 Ensartinib;Erdafitinib;Larotrectinib;Olaparib;PI3K/mTOR Inhibitor LY3023414;Selumetinib Sulfate;Tazemetostat;Vemurafenib
4 Pediatric MATCH: Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations Recruiting NCT03213665 Phase 2 Tazemetostat
5 Pediatric MATCH: Trk Inhibitor LOXO-101 in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions Recruiting NCT03213704 Phase 2 Larotrectinib
6 Pediatric MATCH: PI3K/mTOR Inhibitor LY3023414 in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations Recruiting NCT03213678 Phase 2 PI3K/mTOR Inhibitor LY3023414
7 Pediatric MATCH: Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes Recruiting NCT03233204 Phase 2 Olaparib
8 Pediatric MATCH: Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations Recruiting NCT03220035 Phase 2 Vemurafenib
9 Pediatric MATCH: Pan-FGFR Tyrosine Kinase Inhibitor JNJ-42756493 in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations Not yet recruiting NCT03210714 Phase 2 Erdafitinib
10 Collecting and Storing Tissue From Young Patients With Cancer Recruiting NCT00898755

Search NIH Clinical Center for Langerhans Cell Sarcoma

Cochrane evidence based reviews: langerhans cell sarcoma

Genetic Tests for Langerhans Cell Sarcoma

Anatomical Context for Langerhans Cell Sarcoma

MalaCards organs/tissues related to Langerhans Cell Sarcoma:

39
Bone, Spleen, Lung, Liver, Testes, Lymph Node, Tongue

Publications for Langerhans Cell Sarcoma

Articles related to Langerhans Cell Sarcoma:

(show top 50) (show all 54)
id Title Authors Year
1
Cytological findings of langerhans cell sarcoma in a case of quintuple cancer. ( 28233936 )
2017
2
Langerhans Cell Sarcoma: A Case Report Demonstrating Morphological and Immunophenotypical Variability within a Single Lesion. ( 28626593 )
2017
3
A Case of Pulmonary Langerhans Cell Sarcoma Simultaneously Diagnosed with Cutaneous Langerhans Cell Histiocytosis Studied by Whole-Exome Sequencing. ( 28614815 )
2017
4
Sustained response to salvage therapy for dabrafenib-resistant metastatic Langerhans cell sarcoma. ( 27502715 )
2016
5
Langerhans cell sarcoma originating from left knee subcutaneous tissue: A case report and literature review. ( 27900055 )
2016
6
Langerhans cell sarcoma: an unusual microscopic presentation. ( 27373133 )
2016
7
Langerhans cell sarcoma: a case report and review of the literature. ( 27543873 )
2016
8
Langerhans cell sarcoma of the head and neck. ( 26777877 )
2016
9
Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma: Current Understanding and Differential Diagnosis. ( 27980300 )
2016
10
Cutaneous and breast Langerhans cell sarcoma. ( 26332733 )
2015
11
Langerhans cell sarcoma with lineage infidelity/plasticity: a diagnostic challenge and insight into the pathobiology of the disease. ( 26368646 )
2015
12
Langerhans cell sarcoma arising from the root of tongue: a rare case. ( 26823886 )
2015
13
Dramatic transient improvement of metastatic BRAF(V600E)-mutated Langerhans cell sarcoma under treatment with dabrafenib. ( 26468227 )
2015
14
Langerhans cell sarcoma following marginal zone lymphoma: expanding the knowledge on mature B cell plasticity. ( 26286813 )
2015
15
Langerhans cell sarcoma: A systematic review. ( 25805533 )
2015
16
Diagnostic Value of Wilms Tumor 1 and CD44 in Langerhans Cell Sarcoma: Case Series of 4 Patients. ( 25837753 )
2015
17
Clinical experience of bendamustine for adult Langerhans cell sarcoma. ( 24881923 )
2014
18
High viral load of Merkel cell polyomavirus DNA sequences in Langerhans cell sarcoma tissues. ( 24834110 )
2014
19
A case of an adult Langerhans cell sarcoma. ( 25312302 )
2014
20
Langerhans cell sarcoma: case report and review of world literature. ( 24942035 )
2014
21
Rare case of Langerhans cell sarcoma with cutaneous manifestation arising on the inguinal region. ( 25387842 )
2014
22
Cutaneous Langerhans cell sarcoma relapsing systemically: Complete remission with the EPIG regimen. ( 25186787 )
2014
23
Langerhans cell sarcoma of the nasopharynx: a rare case. ( 24215052 )
2013
24
Langerhans cell sarcoma in two young children: imaging findings on initial presentation and recurrence. ( 23690723 )
2013
25
Unusual cutaneous Langerhans cell sarcoma without extracutaneous involvement. ( 23388086 )
2013
26
Langerhans cell sarcoma: a case report and review of the literature. ( 23557341 )
2013
27
Langerhans Cell Sarcoma Arising from Chronic Lymphocytic Lymphoma/Small Lymphocytic Leukemia: Lineage Analysis and BRAF V600E Mutation Study. ( 23923114 )
2013
28
Expression and anatomical distribution of TIM-containing molecules in Langerhans cell sarcoma. ( 23264111 )
2013
29
Langerhans cell sarcoma: a case report. ( 23590692 )
2013
30
Langerhans cell sarcoma in the cervical lymph node: a case report and literature review. ( 23207655 )
2013
31
Paraneoplastic disseminated lentigines heralding aggressive Langerhans cell sarcoma. ( 22992981 )
2013
32
Langerhans Cell Sarcoma of the Axillary Lymph Node: A Case Report and Review of the Literature. ( 26923635 )
2013
33
Primary cutaneous langerhans cell sarcoma: a report of four cases and review of the literature. ( 23051626 )
2013
34
Langerhans Cell Sarcoma in a Chronic Myelogenous Leukemia Patient Undergoing Imatinib Mesylate Therapy: A Case Study and Review of the Literature. ( 24008437 )
2013
35
Langerhans cell sarcoma in a patient with hairy cell leukemia: common clonal origin indicated by identical immunoglobulin gene rearrangements. ( 22616604 )
2012
36
The characteristic expression of B7-associated proteins in Langerhans cell sarcoma. ( 22305414 )
2012
37
Multifocal Langerhans cell sarcoma involving epidermis: a case report and review. ( 22889043 )
2012
38
The characteristics of FDG PET/CT imaging in pulmonary Langerhans cell sarcoma. ( 22475903 )
2012
39
Langerhans cell sarcoma with an aberrant cytoplasmic CD3 expression. ( 23006414 )
2012
40
Langerhans cell sarcoma: Response to radiotherapy. ( 24376934 )
2010
41
Langerhans cell sarcoma of the cervical lymph node: a case report and literature review. ( 20554413 )
2010
42
Langerhans cell sarcoma involving gallbladder and peritoneal lymph nodes: a case report. ( 18805873 )
2009
43
Chemotherapy for Langerhans cell sarcoma. ( 19337819 )
2009
44
Langerhans cell sarcoma emanating from the upper arm skin: successful treatment by MAID regimen. ( 18274862 )
2008
45
Fine needle aspiration cytology of Langerhans cell sarcoma. ( 18205629 )
2008
46
Leukemic transformation of Langerhans cell sarcoma. ( 18360746 )
2008
47
Primary cutaneous Langerhans cell sarcoma without Birbeck granules: indeterminate cell sarcoma? ( 18422973 )
2008
48
ESHAP therapy effective in a patient with Langerhans cell sarcoma. ( 18415657 )
2008
49
Langerhans cell sarcoma in a patient who underwent transplantation. ( 17659009 )
2007
50
Cutaneous Langerhans cell sarcoma: a case report and review of the literature. ( 17321988 )
2007

Variations for Langerhans Cell Sarcoma

Expression for Langerhans Cell Sarcoma

Search GEO for disease gene expression data for Langerhans Cell Sarcoma.

Pathways for Langerhans Cell Sarcoma

GO Terms for Langerhans Cell Sarcoma

Cellular components related to Langerhans Cell Sarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.5 CD1A CD207 CR1 CR2 HBA1 LY75
2 extracellular exosome GO:0070062 9.02 CR1 CR2 HBA1 LY75 VSIG4

Biological processes related to Langerhans Cell Sarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.5 CR1 CR2 VSIG4
2 immune response GO:0006955 9.43 CD1A CR2 LY75
3 complement activation, classical pathway GO:0006958 9.4 CR1 CR2
4 regulation of complement activation GO:0030449 9.37 CR1 CR2
5 viral entry into host cell GO:0046718 9.16 CR1 CR2
6 immune system process GO:0002376 9.13 CD1A CR1 CR2
7 complement receptor mediated signaling pathway GO:0002430 8.62 CR1 CR2

Molecular functions related to Langerhans Cell Sarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.62 CR1 CR2

Sources for Langerhans Cell Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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