MCID: LRG001
MIFTS: 50

Large Cell Carcinoma malady

Cancer category

Summaries for Large Cell Carcinoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A carcinoma that is composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm.

MalaCards: Large Cell Carcinoma, also known as large cell carcinoma nos, is related to adenocarcinoma and squamous cell carcinoma. An important gene associated with Large Cell Carcinoma is NKX2-1 (NK2 homeobox 1), and among its related pathways is Neuroscience. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include lymph node, thymus and brain, and related mouse phenotypes are renal/urinary system and integument.

Wikipedia:64 Large-cell lung carcinoma (LCLC) is a heterogeneous group of undifferentiated malignant neoplasms... more...

Aliases & Classifications for Large Cell Carcinoma

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

large cell carcinoma 8
large cell carcinoma nos 8
carcinoma, large cell 61
carcinoma large cell 45


External Ids:

Disease Ontology8 DOID:4552
MeSH35 D018287
SNOMED-CT57 189551005, 22687000
NCIt40 C3780

Related Diseases for Large Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Large Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.0NKX2-1, CGB5, STK11, SYP, CHGA, DSC3
2squamous cell carcinoma30.9S100A7, PDGFRA, STK11, CEACAM3, ENO2, PTHLH
3neuroendocrine carcinoma30.8NKX2-1, SYP, CHGA, KRT19, KRT7, ENO2
4bronchogenic carcinoma30.5KRT19, ENO2
5thymic carcinoma30.2CEACAM3, KRT7, SYP, NKX2-1
6hypoglycemia30.0STK11, CHGA
7bladder carcinoma30.0KRT19, CGB5
8hypercalcemia30.0CHGA, PTHLH
9signet ring cell adenocarcinoma30.0CHGA, KRT7
10adenoid cystic carcinoma30.0KRT19, KRT7, CEACAM3
11adenosquamous carcinoma30.0NKX2-1, CHGA, KRT19, KRT7, PTHLH
12small cell carcinoma10.4
13adrenal carcinoma10.3
14thymus large cell carcinoma10.3
15lung occult large cell carcinoma10.2
16pleomorphic carcinoma10.1
17lung giant cell carcinoma10.1
18intussusception10.1
19large cell keratinizing variant squamous cell breast carcinoma10.1
20large cell carcinoma with rhabdoid phenotype10.1
21hemopneumothorax10.0
22lung mixed small cell and squamous cell carcinoma10.0
23clear cell adenocarcinoma10.0
24systemic lupus erythematosus10.0
25spindle cell carcinoma10.0
26bladder signet ring cell adenocarcinoma10.0
27gynecomastia10.0
28n syndrome10.0
29lung adenoid cystic carcinoma10.0
30adenosquamous cell lung carcinoma10.0
31aortic aneurysm10.0
32bladder adenocarcinoma10.0
33bladder clear cell adenocarcinoma10.0
34uveitis10.0
35bronchogenic cyst10.0
36pulmonary function10.0
37stroke, hemorrhagic10.0
38hemangioma10.0NKX2-1
39respiratory failure10.0NKX2-1
40stomatitis10.0CSF3
41ductal carcinoma in situ10.0S100A7
42phaeochromocytoma10.0CHGA
43meningioma10.0SYP
44rhabdoid tumor10.0SYP
45gastritis10.0CHGA
46hypothyroidism10.0NKX2-1
47graves' disease10.0NKX2-1
48sertoli-leydig cell tumor10.0KRT7
49cerebral primitive neuroectodermal tumor10.0ENO2
50splenomegaly10.0CSF3

Graphical network of the top 20 diseases related to Large Cell Carcinoma:



Diseases related to large cell carcinoma

Clinical Features for Large Cell Carcinoma

Drugs & Therapeutics for Large Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Large Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Large Cell Carcinoma

Search NIH Clinical Center for Large Cell Carcinoma

Search CenterWatch for Large Cell Carcinoma

Genetic Tests for Large Cell Carcinoma

Anatomical Context for Large Cell Carcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Large Cell Carcinoma:

33
Lymph node, Thymus, Brain, Skeletal muscle, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Adrenal gland, Breast, Skin, Ovary, Prostate, Cervix, T cells, B cells, Endothelial, Tongue

Animal Models for Large Cell Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Large Cell Carcinoma

Sources:
51PubMed
See all sources

Articles related to Large Cell Carcinoma:

(show top 50)    (show all 427)
idTitleAuthorsYear
1
Distinct profile of driver mutations and clinical features in immunomarker-defined subsets of pulmonary large-cell carcinoma. (24384807)
2014
2
Large cell neuroendocrine carcinoma of the submandibular gland: Case report and literature review. (23953500)
2014
3
Advanced composite of large cell neuroendocrine carcinoma and squamous cell carcinoma: a case report of uterine cervical cancer in a virgin woman. (24062959)
2013
4
Imprint cytological feature of large cell neuroendocrine carcinoma of the gallbladder: a case report. (23614924)
2013
5
Large cell neuroendocrine carcinoma presenting with neck swelling in the submandibular gland: a case report. (23509998)
2013
6
Large-cell neuroendocrine carcinoma of lung with epidermal growth factor receptor (EGFR) gene mutation and co-expression of adenocarcinoma markers: a case report and review of the literature. (23866929)
2013
7
A giant fungating metastatic basal cell carcinoma of the back and novel reconstruction using two large keystone design island perforator flaps. (23623272)
2013
8
Urinary bladder urothelial carcinoma with expression of KIT and PDGFRA and showing diverse differentiations into plasmacytoid, clear cell, acantholytic, nested, and spindle variants, and into adenocarcinoma, signet-ring cell carcinoma, small cell carcinoma, large cell carcinoma, and pleomorphic carcinoma. (23696935)
2013
9
Cytokeratin positivity in anaplastic large cell lymphoma: a potential diagnostic pitfall in misdiagnosis of metastatic carcinoma. (23573330)
2013
10
Intravitreal bevacizumab for iris tumor metastasized from large cell neuroendocrine carcinoma of lung. (23250479)
2013
11
Large cell neuroendocrine carcinoma arising in mature cystic teratoma: a case report and review of the literature. (23091901)
2012
12
Submental transposition flap for a large defect after excision of a recurrent basal cell carcinoma on the chin. (23107332)
2012
13
Large cell neuroendocrine carcinoma of the head and neck. (22751494)
2012
14
Mucosal large cell neuroendocrine carcinoma of the head and neck regions in Japanese patients: a distinct clinicopathological entity. (22718848)
2012
15
TFE3 rearrangements in adult renal cell carcinoma: clinical and pathologic features with outcome in a large series of consecutively treated patients. (22498819)
2012
16
Large-cell neuroendocrine carcinoma of the lung harboring EGFR mutation and responding to gefitinib. (22042963)
2011
17
Merkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in Merkel cell carcinoma. (21642382)
2011
18
Large cell neuroendocrine carcinoma arising from the left main bronchus. (21921385)
2011
19
Toona sinensis extracts induced cell cycle arrest and apoptosis in the human lung large cell carcinoma. (20123594)
2010
20
CD99-positive large cell neuroendocrine carcinoma with rearranged EWSR1 gene in an infant: a case of prognostically favorable tumor. (20617339)
2010
21
Uterine carcinosarcoma metastatic to the lung as large-cell neuroendocrine carcinoma with synchronous sarcoid granulomatosis. (19111933)
2009
22
Mixed ovarian large cell neuroendocrine carcinoma, mucinous adenocarcinoma, and teratoma: a report of two cases and review of the literature. (19577382)
2009
23
Editorial comment on: Large-scale real-time reverse transcription-PCR approach of angiogenic pathways in human transitional cell carcinoma of the bladder: identification of VEGFA as a major independent prognostic marker. (18513852)
2009
24
Incarceration of a large cell neuroendocrine carcinoma arising from the proximal stomach with an organoaxial gastric volvulus through an esophageal hiatal hernia: report of a case. (19198995)
2009
25
Primary large cell neuroendocrine carcinoma of the urinary bladder. (19120517)
2008
26
Genetics of a combined lung small cell carcinoma and large cell neuroendocrine carcinoma with adenocarcinoma. (18551311)
2008
27
Ovarian large cell neuroendocrine carcinoma. (18840191)
2008
28
Coexpression of c-kit and bcl-2 in small cell carcinoma and large cell neuroendocrine carcinoma of the lung. (18091382)
2007
29
Large-cell carcinoma of the lung with a remarkable preoperative elevation of serum carcinoembryonic antigen level. (17554998)
2007
30
Hypoglycemia due to paraneoplastic secretion of insulin-like growth factor-I in a patient with metastasizing large-cell carcinoma of the lung. (17299065)
2007
31
Recurrent autoimmune inner ear disease (AIED) and polyarteritis nodosa in a patient with large cell lung carcinoma. (16552463)
2007
32
Large cell neuroendocrine carcinoma of prostate: a clinicopathologic summary of 7 cases of a rare manifestation of advanced prostate cancer. (16723845)
2006
33
Prospective study of adjuvant chemotherapy for pulmonary large cell neuroendocrine carcinoma. (17062251)
2006
34
Expression of CD30 (Ber-H2) in nasopharyngeal carcinoma, undifferentiated type and lymphoepithelioma-like carcinoma. A comparison study with anaplastic large cell lymphoma. (16722935)
2006
35
Large cell carcinoma with calcitonin and vasoactive intestinal polypeptide-associated Verner-Morrison syndrome. (15667039)
2005
36
Expression of HER-2/neu, epidermal growth factor receptor, vascular endothelial growth factor, cyclooxygenase-2, estrogen receptor, and progesterone receptor in small cell and large cell neuroendocrine carcinoma of the uterine cervix: a clinicopathologic and prognostic study. (16014119)
2005
37
Genetic alterations in early-stage pulmonary large cell neuroendocrine carcinoma. (15022286)
2004
38
5% imiquimod cream for the treatment of large superficial basal cell carcinoma. (15492202)
2004
39
Frequent overexpression of the c-kit protein in large cell neuroendocrine carcinoma of the lung. (12711118)
2003
40
Pulmonary large-cell neuroendocrine carcinoma (LCNEC). (12694759)
2003
41
Tonsillar metastasis from large cell carcinoma of the lung. (11481842)
2001
42
Thyroid transcription factor-1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins A and B. (10632746)
2000
43
The significance of frequent and independent p53 and bcl-2 expression in large-cell neuroendocrine carcinomas of the lung. (10229500)
1999
44
Predictive score for the development of hepatocellular carcinoma and additional value of liver large cell dysplasia in Western patients with cirrhosis. (8621142)
1996
45
Intrinsic cellular resistance to oxazaphosphorines exhibited by a human colon carcinoma cell line expressing relatively large amounts of a class-3 aldehyde dehydrogenase. (7986206)
1994
46
Eosinophilic gastroenteritis in a patient with large-cell anaplastic lung carcinoma: a paraneoplastic syndrome? (7812030)
1994
47
Annulate lamellae in a large cell lung carcinoma cell line with high expression of tyrosine kinase receptor and proto-oncogenes. (1354400)
1992
48
Vindesine in the treatment of squamous cell carcinoma, adenocarcinoma, and large cell carcinoma of the lung. (7055816)
1982
49
Combination chemotherapy with methyl-CCNU, 5-fluorouracil, and vincristine in adenocarcinoma and large cell carcinoma of the lung. (189924)
1976
50
Ectopic gonadotropin in a case of anaplastic large-cell carcinoma of the lung. (4136650)
1974

Genetic Variations for Large Cell Carcinoma

Expression for genes affiliated with Large Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Large Cell Carcinoma

Search GEO for disease gene expression data for Large Cell Carcinoma.

Pathways for genes affiliated with Large Cell Carcinoma

Sources:
4Cell Signaling Technology
See all sources

Pathways related to Large Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9ENO2, SYP, NKX2-1, UCHL1

Compounds for genes affiliated with Large Cell Carcinoma

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience
See all sources

Compounds related to Large Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7S100A7
2cycloheximide4510.6CGB5
3s 1004510.3CHGA, ENO2, SYP
4smcc4510.2SYP, ENO2, CHGA, KRT19
5mucicarmine4510.1SYP, CEACAM3, KRT7, NKX2-1
6gossypol4510.1MCL1, BAK1, CGB5
7l-amino acid4510.1SYP, CHGA, ENO2
85-hydroxyindoleacetic acid45 2411.1CEACAM3, ENO2, CHGA
9serine4510.0KRT19, SYP, NKX2-1, STK11, UCHL1
10dexamethasone45 50 29 1112.9BAK1, ENO2, MCL1, CGB5, NKX2-1
11dbc-amp459.9CGB5, ENO2, SYP, THBD, PTHLH
12acth459.8CEACAM3, CGB5, SYP, CHGA, ENO2
13cyclophosphamide45 50 1111.8CHGA, PTHLH, THBD, MCL1, CGB5, CSF3
14formaldehyde45 2410.8SYP, CHGA, KRT7, ENO2, KRT19, NKX2-1
1512-o-tetradecanoylphorbol 13-acetate459.8UCHL1, BAK1, MCL1, CHGA, PTHLH
16matrigel459.7CHGA, PTHLH, KRT7, KRT19, THBD
17glycogen45 2410.7STK11, SYP, CGB5, PTHLH, KRT7, MCL1
18cyclic amp45 2410.7CHGA, SYP, NKX2-1, CGB5, STK11, PTHLH
19ribonucleic acid459.7NKX2-1, CHGA, PTHLH, KRT19, ENO2, CGB5
20ibmx45 29 6011.7THBD, CGB5, PTHLH, ENO2
21dmso459.7ENO2, CSF3, CGB5, CHGA, BAK1, THBD
22nifedipine45 50 29 1112.7CHGA, THBD, CGB5, PTHLH
23methotrexate45 50 1111.6KRT7, ENO2, CSF3, CEACAM3, CGB5
24paclitaxel45 50 1111.6KRT19, MCL1, BAK1, CHGA, CGB5, CSF3
25b 723459.6THBD, CHGA, NKX2-1, SYP, CEACAM3, KRT7
26norepinephrine45 11 2411.6PTHLH, ENO2, CGB5, CHGA, SYP
27etoposide45 50 60 1112.6ENO2, CSF3, SYP, CHGA, BAK1, MCL1
28superoxide45 2410.6UCHL1, ENO2, CSF3, CGB5, SYP, BAK1
29hematoxylin459.6KRT7, ENO2, CEACAM3, CHGA, SYP, NKX2-1
30fibrinogen459.5CEACAM3, CHGA, THBD, CGB5, KRT19
31forskolin45 50 1111.5CHGA, PTHLH, THBD, MCL1, SYP, NKX2-1
32creatinine459.5KRT19, THBD, CEACAM3, PTHLH, CHGA, SYP
33streptavidin459.5KRT7, CGB5, CEACAM3
34steroid459.5NKX2-1, CGB5, CEACAM3, PTHLH, KRT19, THBD
35aspartate459.4THBD, KRT19, ENO2, CEACAM3, MCL1, PDGFRA
36thymidine45 2410.4PTHLH, KRT19, CSF3, PDGFRA, CEACAM3, ENO2
37testosterone45 60 11 2412.4ENO2, PTHLH, KRT7, KRT19, SYP, CHGA
38lactate459.4THBD, KRT19, CGB5, PTHLH, CEACAM3, CHGA
39nitric oxide45 11 2411.3BAK1, CGB5, CEACAM3, ENO2, THBD, PTHLH
40atp45 2910.3CHGA, ENO2, CGB5, PDGFRA, PTHLH, KRT19
41lipid459.2STK11, CGB5, SYP, CHGA, MCL1, THBD
42glucose459.2BAK1, THBD, CGB5, STK11, PTHLH, KRT19
43cisplatin45 50 60 1112.1CGB5, CSF3, SYP, CHGA, BAK1, ENO2
44progesterone45 60 29 11 2413.0ENO2, CEACAM3, KRT7, KRT19, THBD, CHGA
45oxygen45 249.9MCL1, PTHLH, S100A7, STK11, KRT19, CGB5
46vegf458.4CGB5, PDGFRA, MCL1, THBD, KRT19, KRT7
47paraffin458.3STK11, NKX2-1, THBD, PDGFRA, CEACAM3, ENO2
48retinoic acid45 249.3CSF3, PDGFRA, S100A7, CGB5, NKX2-1, THBD
49calcium45 50 11 2411.2MCL1, BAK1, DSC3, KRT19, DSC2, CHGA
50tyrosine458.1PDGFRA, CEACAM3, PTHLH, KRT19, BAK1, THBD

GO Terms for genes affiliated with Large Cell Carcinoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Large Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Leydig cell differentiationGO:03332710.2NKX2-1, PDGFRA
2negative regulation of platelet activationGO:0105449.8THBD, PDGFRA

Products for genes affiliated with Large Cell Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Large Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet