MCID: LRG001
MIFTS: 53

Large Cell Carcinoma malady

Cancer diseases category

Summaries for Large Cell Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A carcinoma that is composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm.

MalaCards: Large Cell Carcinoma, also known as large cell carcinoma nos, is related to adenocarcinoma and lung adenocarcinoma. An important gene associated with Large Cell Carcinoma is NKX2-1 (NK2 homeobox 1), and among its related pathways is Neuroscience. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include lung, cervix and colon, and related mouse phenotypes are renal/urinary system and integument.

Wikipedia:63 Large-cell lung carcinoma (LCLC) is a heterogeneous group of undifferentiated malignant neoplasms... more...

Aliases & Classifications for Large Cell Carcinoma

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

large cell carcinoma 8
large cell carcinoma nos 8
carcinoma, large cell 60
carcinoma large cell 44


External Ids:

Disease Ontology8 DOID:4552
MeSH34 D018287
SNOMED-CT56 189551005, 22687000
NCIt39 C3780

Related Diseases for Large Cell Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Basal Cell Carcinoma family:

Small Cell Carcinoma large cell carcinoma
Cell Type Benign Neoplasm Cell Type Cancer
Basal Cell Carcinoma, Multiple Basal Cell Carcinoma 1
Basal Cell Carcinoma 2 Basal Cell Carcinoma 3
Basal Cell Carcinoma 6 Basal Cell Carcinoma 5
Basal Cell Carcinoma 4 Basal Cell Carcinoma 7

Diseases related to Large Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 173)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.0NKX2-1, KRT7, CEACAM3, ENO2, PTHLH, KRT19
2lung adenocarcinoma30.9KRT7, KRT19, STK11, THBD, NKX2-1, CEACAM3
3lung squamous cell carcinoma30.9KRT19, PTHLH
4squamous cell carcinoma30.8S100A7, CEACAM3, ENO2, PTHLH, KRT7, KRT19
5neuroendocrine carcinoma30.8CHGA, ENO2, KRT7, SYP, KRT19, NKX2-1
6lung small cell carcinoma30.6NKX2-1, SYP, CHGA, KRT7, PTHLH, ENO2
7bronchogenic carcinoma30.5KRT19, ENO2
8lung cancer30.3KRT19, UCHL1, PDGFRA, MCL1, PTHLH, NKX2-1
9neuroendocrine tumor30.2CHGA, ENO2, KRT19, CEACAM3, SYP, NKX2-1
10hypoglycemia29.9CHGA, STK11
11bladder carcinoma29.9KRT19, CGB5
12hypercalcemia29.9PTHLH, CHGA
13signet ring cell adenocarcinoma29.9KRT7, CHGA
14adenoid cystic carcinoma29.9KRT19, KRT7, CEACAM3
15adenosquamous carcinoma29.9CHGA, NKX2-1, KRT7, PTHLH, KRT19
16melanoma29.9STK11, CEACAM3, PDGFRA, NKX2-1, ENO2, MCL1
17lung large cell carcinoma11.0
18small cell carcinoma10.4
19large cell carcinoma with rhabdoid phenotype10.4
20pulmonary large cell neuroendocrine carcinoma10.3
21adrenal carcinoma10.3
22thymus large cell carcinoma10.3
23lung occult large cell carcinoma10.2
24pleomorphic carcinoma10.1
25lung giant cell carcinoma10.1
26intussusception10.1
27large cell keratinizing variant squamous cell breast carcinoma10.1
28duodenitis10.1
29thymic carcinoma10.1
30thyroiditis10.1
31hemangioma10.0NKX2-1
32respiratory failure10.0NKX2-1
33stomatitis10.0CSF3
34ductal carcinoma in situ10.0S100A7
35phaeochromocytoma10.0CHGA
36meningioma10.0SYP
37rhabdoid tumor10.0SYP
38gastritis10.0CHGA
39hypothyroidism10.0NKX2-1
40graves' disease10.0NKX2-1
41sertoli-leydig cell tumor10.0KRT7
42hemopneumothorax10.0
43lung mixed small cell and squamous cell carcinoma10.0
44lung carcinoma in situ10.0
45clear cell adenocarcinoma10.0
46systemic lupus erythematosus10.0
47spindle cell carcinoma10.0
48bladder signet ring cell adenocarcinoma10.0
49gynecomastia10.0
50lung adenoid cystic carcinoma10.0

Graphical network of the top 20 diseases related to Large Cell Carcinoma:



Diseases related to large cell carcinoma

Clinical Features for Large Cell Carcinoma

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Drugs & Therapeutics for Large Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Large Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Large Cell Carcinoma

Search NIH Clinical Center for Large Cell Carcinoma

Search CenterWatch for Large Cell Carcinoma

Genetic Tests for Large Cell Carcinoma

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Anatomical Context for Large Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Large Cell Carcinoma:

32
Lung, Cervix, Colon, Ovary, Prostate, Thymus, Breast, Thyroid, Liver, Kidney, Brain, B cells, Lymph node, Pancreas, Endothelial, Small intestine, Tongue, T cells, Skeletal muscle, Skin

Animal Models for Large Cell Carcinoma or affiliated genes

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36MGI
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Publications for Large Cell Carcinoma

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50PubMed
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Articles related to Large Cell Carcinoma:

(show top 50)    (show all 424)
idTitleAuthorsYear
1
Distinct profile of driver mutations and clinical features in immunomarker-defined subsets of pulmonary large-cell carcinoma. (24384807)
2014
2
Large cell neuroendocrine carcinoma of the submandibular gland: Case report and literature review. (23953500)
2014
3
Endoscopic ultrasound-guided fine-needle aspiration diagnosis of large cell neuroendocrine carcinoma of the gallbladder and common bile duct: report of a case. (22623519)
2013
4
A giant fungating metastatic basal cell carcinoma of the back and novel reconstruction using two large keystone design island perforator flaps. (23623272)
2013
5
Urinary bladder urothelial carcinoma with expression of KIT and PDGFRA and showing diverse differentiations into plasmacytoid, clear cell, acantholytic, nested, and spindle variants, and into adenocarcinoma, signet-ring cell carcinoma, small cell carcinoma, large cell carcinoma, and pleomorphic carcinoma. (23696935)
2013
6
Cytokeratin positivity in anaplastic large cell lymphoma: a potential diagnostic pitfall in misdiagnosis of metastatic carcinoma. (23573330)
2013
7
Fatal Hepatocellular Carcinoma in a Patient with Occult Hepatitis B Virus Infection following the Administration of R-CHOP for Diffuse Large B-Cell Lymphoma. (23326737)
2012
8
Metastatic gastric large cell neuroendocrine carcinoma: a case report and review of literature. (22421002)
2012
9
Large cell neuroendocrine carcinoma of the head and neck. (22751494)
2012
10
Mucosal large cell neuroendocrine carcinoma of the head and neck regions in Japanese patients: a distinct clinicopathological entity. (22718848)
2012
11
TFE3 rearrangements in adult renal cell carcinoma: clinical and pathologic features with outcome in a large series of consecutively treated patients. (22498819)
2012
12
Brain metastasis from large cell neuroendocrine carcinoma of the urinary bladder. (21748036)
2011
13
Identity, similarity, and difference between large cell neuroendocrine carcinoma and small cell carcinoma. (21918392)
2011
14
Merkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in Merkel cell carcinoma. (21642382)
2011
15
Large cell neuroendocrine carcinoma arising from the left main bronchus. (21921385)
2011
16
Thymic large cell neuroendocrine carcinoma: report of a resected case - a case report. (21092193)
2010
17
Toona sinensis extracts induced cell cycle arrest and apoptosis in the human lung large cell carcinoma. (20123594)
2010
18
CD99-positive large cell neuroendocrine carcinoma with rearranged EWSR1 gene in an infant: a case of prognostically favorable tumor. (20617339)
2010
19
Large superficial basal cell carcinoma arising from moxa cautery. (19451052)
2009
20
Postoperative recurrence and the role of adjuvant chemotherapy in patients with pulmonary large-cell neuroendocrine carcinoma. (19619794)
2009
21
Large cell neuroendocrine carcinoma of the ovary associated with serous carcinoma with mucin production: a case report and literature review. (19079625)
2009
22
Differential Thymidylate Synthase Expression in Different Variants of Large-Cell Carcinoma of the Lung. (19996214)
2009
23
Uterine carcinosarcoma metastatic to the lung as large-cell neuroendocrine carcinoma with synchronous sarcoid granulomatosis. (19111933)
2009
24
Mixed ovarian large cell neuroendocrine carcinoma, mucinous adenocarcinoma, and teratoma: a report of two cases and review of the literature. (19577382)
2009
25
Editorial comment on: Large-scale real-time reverse transcription-PCR approach of angiogenic pathways in human transitional cell carcinoma of the bladder: identification of VEGFA as a major independent prognostic marker. (18513852)
2009
26
Incarceration of a large cell neuroendocrine carcinoma arising from the proximal stomach with an organoaxial gastric volvulus through an esophageal hiatal hernia: report of a case. (19198995)
2009
27
Fine-needle aspiration cytology of large cell neuroendocrine carcinoma of the lung: a cytohistologic correlation study of 11 cases. (18433011)
2008
28
Genetics of a combined lung small cell carcinoma and large cell neuroendocrine carcinoma with adenocarcinoma. (18551311)
2008
29
Ovarian large cell neuroendocrine carcinoma. (18840191)
2008
30
Coexpression of c-kit and bcl-2 in small cell carcinoma and large cell neuroendocrine carcinoma of the lung. (18091382)
2007
31
p53 immunostaining is correlated with reduced survival and is not correlated with gene mutations in resected pulmonary large cell carcinomas. (17665040)
2007
32
Hypoglycemia due to paraneoplastic secretion of insulin-like growth factor-I in a patient with metastasizing large-cell carcinoma of the lung. (17299065)
2007
33
Recurrent autoimmune inner ear disease (AIED) and polyarteritis nodosa in a patient with large cell lung carcinoma. (16552463)
2007
34
Expression of CD30 (Ber-H2) in nasopharyngeal carcinoma, undifferentiated type and lymphoepithelioma-like carcinoma. A comparison study with anaplastic large cell lymphoma. (16722935)
2006
35
Expression of HER-2/neu, epidermal growth factor receptor, vascular endothelial growth factor, cyclooxygenase-2, estrogen receptor, and progesterone receptor in small cell and large cell neuroendocrine carcinoma of the uterine cervix: a clinicopathologic and prognostic study. (16014119)
2005
36
Pulmonary large-cell neuroendocrine carcinoma (LCNEC). (12694759)
2003
37
Tonsillar metastasis from large cell carcinoma of the lung. (11481842)
2001
38
Large acinar cell carcinoma of the pancreas in a patient with elevated serum AFP level. (10982618)
2000
39
Thyroid transcription factor-1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins A and B. (10632746)
2000
40
Large cell carcinoma of the lung metastatic to nuchal muscle. (9525301)
1997
41
Predictive score for the development of hepatocellular carcinoma and additional value of liver large cell dysplasia in Western patients with cirrhosis. (8621142)
1996
42
Phase II trial of carboplatin in combination with etoposide in locally advanced large cell carcinoma and adenocarcinoma of the lung. (7655835)
1995
43
Eosinophilic gastroenteritis in a patient with large-cell anaplastic lung carcinoma: a paraneoplastic syndrome? (7812030)
1994
44
Myasthenic (Eaton-Lambert) syndrome associated with pulmonary large-cell neuroendocrine carcinoma. (7973914)
1994
45
Annulate lamellae in a large cell lung carcinoma cell line with high expression of tyrosine kinase receptor and proto-oncogenes. (1354400)
1992
46
Karyotypic evolution of a human undifferentiated large cell carcinoma of the lung in tissue culture. (2720688)
1989
47
Establishment of a G-CSF and GM-CSF producing cell line from human large cell carcinoma of the lung. (2477274)
1989
48
Large-cell carcinoma metastatic to the jaw. Report of a case. (269332)
1977
49
Combination chemotherapy with methyl-CCNU, 5-fluorouracil, and vincristine in adenocarcinoma and large cell carcinoma of the lung. (189924)
1976
50
Ectopic gonadotropin in a case of anaplastic large-cell carcinoma of the lung. (4136650)
1974

Genetic Variations for Large Cell Carcinoma

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Expression for genes affiliated with Large Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Large Cell Carcinoma

Search GEO for disease gene expression data for Large Cell Carcinoma.

Pathways for genes affiliated with Large Cell Carcinoma

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4Cell Signaling Technology
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Pathways related to Large Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9ENO2, SYP, NKX2-1, UCHL1

Compounds for genes affiliated with Large Cell Carcinoma

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44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience
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Compounds related to Large Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7S100A7
2cycloheximide4410.6CGB5
3s 1004410.3CHGA, ENO2, SYP
4smcc4410.2SYP, ENO2, CHGA, KRT19
5mucicarmine4410.1SYP, CEACAM3, KRT7, NKX2-1
6gossypol4410.1MCL1, BAK1, CGB5
7l-amino acid4410.1SYP, CHGA, ENO2
85-hydroxyindoleacetic acid44 2411.1CEACAM3, ENO2, CHGA
9serine4410.0KRT19, SYP, NKX2-1, STK11, UCHL1
10dexamethasone44 49 28 1112.9BAK1, ENO2, MCL1, CGB5, NKX2-1
11dbc-amp449.9CGB5, ENO2, SYP, THBD, PTHLH
12acth449.8CEACAM3, CGB5, SYP, CHGA, ENO2
13cyclophosphamide44 49 1111.8CHGA, PTHLH, THBD, MCL1, CGB5, CSF3
14formaldehyde44 2410.8SYP, CHGA, KRT7, ENO2, KRT19, NKX2-1
1512-o-tetradecanoylphorbol 13-acetate449.8UCHL1, BAK1, MCL1, CHGA, PTHLH
16matrigel449.7CHGA, PTHLH, KRT7, KRT19, THBD
17glycogen44 2410.7STK11, SYP, CGB5, PTHLH, KRT7, MCL1
18cyclic amp44 2410.7CHGA, SYP, NKX2-1, CGB5, STK11, PTHLH
19ribonucleic acid449.7NKX2-1, CHGA, PTHLH, KRT19, ENO2, CGB5
20ibmx44 28 5911.7THBD, CGB5, PTHLH, ENO2
21dmso449.7ENO2, CSF3, CGB5, CHGA, BAK1, THBD
22nifedipine44 49 28 1112.7CHGA, THBD, CGB5, PTHLH
23methotrexate44 49 1111.6KRT7, ENO2, CSF3, CEACAM3, CGB5
24paclitaxel44 49 1111.6KRT19, MCL1, BAK1, CHGA, CGB5, CSF3
25b 723449.6THBD, CHGA, NKX2-1, SYP, CEACAM3, KRT7
26norepinephrine44 11 2411.6PTHLH, ENO2, CGB5, CHGA, SYP
27etoposide44 49 59 1112.6ENO2, CSF3, SYP, CHGA, BAK1, MCL1
28superoxide44 2410.6UCHL1, ENO2, CSF3, CGB5, SYP, BAK1
29hematoxylin449.6KRT7, ENO2, CEACAM3, CHGA, SYP, NKX2-1
30fibrinogen449.5CEACAM3, CHGA, THBD, CGB5, KRT19
31forskolin44 49 1111.5CHGA, PTHLH, THBD, MCL1, SYP, NKX2-1
32creatinine449.5KRT19, THBD, CEACAM3, PTHLH, CHGA, SYP
33streptavidin449.5KRT7, CGB5, CEACAM3
34steroid449.5NKX2-1, CGB5, CEACAM3, PTHLH, KRT19, THBD
35aspartate449.4THBD, KRT19, ENO2, CEACAM3, MCL1, PDGFRA
36thymidine44 2410.4PTHLH, KRT19, CSF3, PDGFRA, CEACAM3, ENO2
37testosterone44 59 11 2412.4ENO2, PTHLH, KRT7, KRT19, SYP, CHGA
38lactate449.4THBD, KRT19, CGB5, PTHLH, CEACAM3, CHGA
39nitric oxide44 11 2411.3BAK1, CGB5, CEACAM3, ENO2, THBD, PTHLH
40atp44 2810.3CHGA, ENO2, CGB5, PDGFRA, PTHLH, KRT19
41lipid449.2STK11, CGB5, SYP, CHGA, MCL1, THBD
42glucose449.2BAK1, THBD, CGB5, STK11, PTHLH, KRT19
43cisplatin44 49 59 1112.1CGB5, CSF3, SYP, CHGA, BAK1, ENO2
44progesterone44 59 28 11 2413.0ENO2, CEACAM3, KRT7, KRT19, THBD, CHGA
45oxygen44 249.9MCL1, PTHLH, S100A7, STK11, KRT19, CGB5
46vegf448.4CGB5, PDGFRA, MCL1, THBD, KRT19, KRT7
47paraffin448.3STK11, NKX2-1, THBD, PDGFRA, CEACAM3, ENO2
48retinoic acid44 249.3CSF3, PDGFRA, S100A7, CGB5, NKX2-1, THBD
49calcium44 49 11 2411.2MCL1, BAK1, DSC3, KRT19, DSC2, CHGA
50tyrosine448.1PDGFRA, CEACAM3, PTHLH, KRT19, BAK1, THBD

GO Terms for genes affiliated with Large Cell Carcinoma

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16Gene Ontology
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Biological processes related to Large Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Leydig cell differentiationGO:03332710.2NKX2-1, PDGFRA
2negative regulation of platelet activationGO:0105449.8THBD, PDGFRA

Products for genes affiliated with Large Cell Carcinoma

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  • Antibodies
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Sources for Large Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet