MCID: LRG001
MIFTS: 53

Large Cell Carcinoma malady

Cancer diseases category

Summaries for Large Cell Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A carcinoma that is composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm.

MalaCards: Large Cell Carcinoma, also known as large cell carcinoma nos, is related to adenocarcinoma and lung adenocarcinoma. An important gene associated with Large Cell Carcinoma is NKX2-1 (NK2 homeobox 1), and among its related pathways is Neuroscience. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include lung, cervix and colon, and related mouse phenotypes are renal/urinary system and integument.

Wikipedia:63 Large-cell lung carcinoma (LCLC) is a heterogeneous group of undifferentiated malignant neoplasms... more...

Aliases & Classifications for Large Cell Carcinoma

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Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

large cell carcinoma 8
large cell carcinoma nos 8
carcinoma, large cell 60
carcinoma large cell 44


External Ids:

Disease Ontology8 DOID:4552
MeSH34 D018287
SNOMED-CT56 189551005, 22687000
NCIt39 C3780

Related Diseases for Large Cell Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Basal Cell Carcinoma family:

Small Cell Carcinoma large cell carcinoma
Cell Type Benign Neoplasm Cell Type Cancer
Basal Cell Carcinoma, Multiple Basal Cell Carcinoma 1
Basal Cell Carcinoma 2 Basal Cell Carcinoma 3
Basal Cell Carcinoma 6 Basal Cell Carcinoma 5
Basal Cell Carcinoma 4 Basal Cell Carcinoma 7

Diseases related to Large Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 173)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.0NKX2-1, KRT7, CEACAM3, ENO2, PTHLH, KRT19
2lung adenocarcinoma30.9KRT7, KRT19, STK11, THBD, NKX2-1, CEACAM3
3lung squamous cell carcinoma30.9KRT19, PTHLH
4squamous cell carcinoma30.8S100A7, CEACAM3, ENO2, PTHLH, KRT7, KRT19
5neuroendocrine carcinoma30.8CHGA, ENO2, KRT7, SYP, KRT19, NKX2-1
6lung small cell carcinoma30.6NKX2-1, SYP, CHGA, KRT7, PTHLH, ENO2
7bronchogenic carcinoma30.5KRT19, ENO2
8lung cancer30.3KRT19, UCHL1, PDGFRA, MCL1, PTHLH, NKX2-1
9neuroendocrine tumor30.2CHGA, ENO2, KRT19, CEACAM3, SYP, NKX2-1
10hypoglycemia29.9CHGA, STK11
11bladder carcinoma29.9KRT19, CGB5
12hypercalcemia29.9PTHLH, CHGA
13signet ring cell adenocarcinoma29.9KRT7, CHGA
14adenoid cystic carcinoma29.9KRT19, KRT7, CEACAM3
15adenosquamous carcinoma29.9CHGA, NKX2-1, KRT7, PTHLH, KRT19
16melanoma29.9STK11, CEACAM3, PDGFRA, NKX2-1, ENO2, MCL1
17lung large cell carcinoma11.0
18small cell carcinoma10.4
19large cell carcinoma with rhabdoid phenotype10.4
20pulmonary large cell neuroendocrine carcinoma10.3
21adrenal carcinoma10.3
22thymus large cell carcinoma10.3
23lung occult large cell carcinoma10.2
24pleomorphic carcinoma10.1
25lung giant cell carcinoma10.1
26intussusception10.1
27large cell keratinizing variant squamous cell breast carcinoma10.1
28duodenitis10.1
29thymic carcinoma10.1
30thyroiditis10.1
31hemangioma10.0NKX2-1
32respiratory failure10.0NKX2-1
33stomatitis10.0CSF3
34ductal carcinoma in situ10.0S100A7
35phaeochromocytoma10.0CHGA
36meningioma10.0SYP
37rhabdoid tumor10.0SYP
38gastritis10.0CHGA
39hypothyroidism10.0NKX2-1
40graves' disease10.0NKX2-1
41sertoli-leydig cell tumor10.0KRT7
42hemopneumothorax10.0
43lung mixed small cell and squamous cell carcinoma10.0
44lung carcinoma in situ10.0
45clear cell adenocarcinoma10.0
46systemic lupus erythematosus10.0
47spindle cell carcinoma10.0
48bladder signet ring cell adenocarcinoma10.0
49gynecomastia10.0
50lung adenoid cystic carcinoma10.0

Graphical network of the top 20 diseases related to Large Cell Carcinoma:



Diseases related to large cell carcinoma

Clinical Features for Large Cell Carcinoma

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Drugs & Therapeutics for Large Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Large Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Large Cell Carcinoma

Search NIH Clinical Center for Large Cell Carcinoma

Search CenterWatch for Large Cell Carcinoma

Genetic Tests for Large Cell Carcinoma

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Anatomical Context for Large Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Large Cell Carcinoma:

32
Lung, Cervix, Colon, Ovary, Prostate, Thymus, Breast, Thyroid, Liver, Kidney, Brain, B cells, Lymph node, Pancreas, Endothelial, Small intestine, Tongue, T cells, Skeletal muscle, Skin

Animal Models for Large Cell Carcinoma or affiliated genes

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36MGI
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Publications for Large Cell Carcinoma

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50PubMed
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Articles related to Large Cell Carcinoma:

(show top 50)    (show all 424)
idTitleAuthorsYear
1
Distinct profile of driver mutations and clinical features in immunomarker-defined subsets of pulmonary large-cell carcinoma. (23196793)
2013
2
Anaplastic large-cell lymphoma with aberrant expression of multiple cytokeratins masquerading as metastatic carcinoma of unknown primary. (23775969)
2013
3
Clinicopathologic features of primary Merkel cell carcinoma: a detailed descriptive analysis of a large contemporary cohort. (23551620)
2013
4
Primary large cell neuroendocrine carcinoma of the ureter. (23573321)
2013
5
Stress protein Hsp27 expression predicts the outcome in operated small cell lung carcinoma and large cell neuroendocrine carcinoma patients. (24344017)
2013
6
Mixed squamous and large-cell carcinoma of the lung: a case study and literature review. (23174733)
2012
7
Pure large cell neuroendocrine carcinoma of ovary: a rare clinical entity and review of literature. (23304586)
2012
8
Chromophobe renal cell carcinoma (RCC): oncological outcomes and prognostic factors in a large multicentre series. (22044519)
2012
9
Large-cell neuroendocrine carcinoma with epidermal growth factor receptor mutation: possible transformation of lung adenocarcinoma. (22943430)
2012
10
hGH and GHR expression in large cell neuroendocrine carcinoma of the colon and rectum. (22843918)
2012
11
Large cell neuroendocrine carcinoma arising in a sessile serrated adenoma: a novel observation. (22079354)
2012
12
Merkel cell carcinoma with heterologous rhabdomyoblastic differentiation: the role of immunohistochemistry for Merkel cell polyomavirus large T-antigen in confirmation. (22032237)
2012
13
Large cell neuroendocrine carcinoma of the head and neck. (22024350)
2012
14
Thymic large-cell neuroendocrine carcinoma: a disease neglected in the ESMO guideline? (22024725)
2011
15
The balance between the expressions of hASH1 and HES1 differs between large cell neuroendocrine carcinoma and small cell carcinoma of the lung. (21601304)
2011
16
CK20 Positive Large-cell Neuroendocrine Carcinoma Presenting with Skin Metastases. (22028564)
2011
17
Large cell neuroendocrine carcinoma of the endometrium: an extremely uncommon diagnosis, but worth the efforts. (21768718)
2011
18
Prosthetic rehabilitation of a patient with a large mid face defect secondary to Basal cell carcinoma. (22654357)
2011
19
Large-cell neuroendocrine carcinoma: controversies in diagnosis and treatment. (21975912)
2011
20
Urinary cytologic features of primary large cell neuroendocrine carcinoma of the urinary bladder: a case report. (20518415)
2010
21
Giant intracardiac neoplasic thrombus of a large cell neuroendocrine carcinoma of the lung. (19144545)
2010
22
Primary large cell neuroendocrine carcinoma of the vagina: cytomorphology of previously unreported case. (20222107)
2010
23
Clinical response of large cell neuroendocrine carcinoma of the lung to perioperative adjuvant chemotherapy. (19770636)
2010
24
Primary large-cell neuroendocrine carcinoma of the scrotum. (20559878)
2010
25
Cushing's syndrome caused by an ACTH-producing large cell neuroendocrine carcinoma of the gallbladder. (21160818)
2010
26
Intravascular ALK-positive anaplastic large-cell lymphoma mimicking inflammatory breast carcinoma. (19364961)
2009
27
Small large-cell neuroendocrine carcinoma in a patient with pulmonary emphysema. (19533442)
2009
28
Large-cell neuroendocrine carcinoma of the uterine cervix complicating pregnancy. (19197101)
2009
29
Large-cell neuroendocrine carcinoma without immunohistological positivity or serum elevation of CEA until relapse. (19002754)
2008
30
Identification of HLA-A24 restricted shared antigen recognized by autologous cytotoxic T lymphocytes from a patient with large cell carcinoma of the lung. (17131342)
2007
31
Defective expression of transforming growth factor beta type II receptor (TGFBR2) in the large cell variant of non-small cell lung carcinoma. (17566598)
2007
32
Primary large cell neuroendocrine carcinoma of the submandibular gland: unique presentation and surprising treatment response. (18684351)
2007
33
Novel microdeletion in the transforming growth factor beta type II receptor gene is associated with giant and large cell variants of nonsmall cell lung carcinoma. (17117417)
2007
34
Composite large cell neuroendocrine carcinoma and adenocarcinoma of the common bile duct. (16394290)
2006
35
Large cell neuroendocrine carcinoma of the lung: a comparison with large cell carcinoma with neuroendocrine morphology and small cell carcinoma. (15639721)
2005
36
Diffuse subcutaneous calcinosis as the initial presentation of dermatomyositis in a patient with large-cell lung carcinoma. (16325661)
2005
37
Solitary adrenal metastasis in large cell carcinoma of lung. (15558361)
2004
38
Combined large cell neuroendocrine carcinoma and spindle cell carcinoma of the lung. (11510007)
2001
39
Fibrillary co-deposition of laminin-5 and large unspliced tenascin-C in the invasive front of oral squamous cell carcinoma in vivo and in vitro. (11355143)
2001
40
Large cell neuroendocrine carcinoma of the lung: a histologic and immunohistochemical study of 22 cases. (9591721)
1998
41
Primary, pure, large-cell neuroendocrine carcinoma of the urinary bladder. (9796733)
1998
42
Left atrial metastasis of a large cell carcinoma of the lung in an asymptomatic patient: transesophageal echocardiographic evaluation. (9188003)
1997
43
Mixed small cell/large cell carcinoma of the lung. Report of a case with cytologic features and ultrastructural correlation. (7483994)
1995
44
A large cell-adhesive scatter factor secreted by human gastric carcinoma cells. (8265624)
1993
45
Clinical applications of the pathological properties of small cell carcinoma, large cell carcinoma, and adenoid cystic carcinoma of the lung. (2154027)
1990
46
Large cell carcinoma of the lung: a highly aggressive tumor with dismal prognosis. (2547348)
1989
47
Is adenocarcinoma/large cell carcinoma the most radiocurable type of cancer of the lung? (3019958)
1986
48
Large cell carcinoma of the lung--ultrastructural and immunohistochemical studies. (2410641)
1985
49
Frequency of brain metastasis in adenocarcinoma and large cell carcinoma of the lung: correlation with survival. (6313558)
1983
50
Bronchogenic large-cell carcinoma. (14851490)
1951

Genetic Variations for Large Cell Carcinoma

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Expression for genes affiliated with Large Cell Carcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Large Cell Carcinoma

Search GEO for disease gene expression data for Large Cell Carcinoma.

Pathways for genes affiliated with Large Cell Carcinoma

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4Cell Signaling Technology
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Pathways related to Large Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9ENO2, SYP, NKX2-1, UCHL1

Compounds for genes affiliated with Large Cell Carcinoma

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience
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Compounds related to Large Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7S100A7
2cycloheximide4410.6CGB5
3s 1004410.3CHGA, ENO2, SYP
4smcc4410.2SYP, ENO2, CHGA, KRT19
5mucicarmine4410.1SYP, CEACAM3, KRT7, NKX2-1
6gossypol4410.1MCL1, BAK1, CGB5
7l-amino acid4410.1SYP, CHGA, ENO2
85-hydroxyindoleacetic acid44 2411.1CEACAM3, ENO2, CHGA
9serine4410.0KRT19, SYP, NKX2-1, STK11, UCHL1
10dexamethasone44 49 28 1112.9BAK1, ENO2, MCL1, CGB5, NKX2-1
11dbc-amp449.9CGB5, ENO2, SYP, THBD, PTHLH
12acth449.8CEACAM3, CGB5, SYP, CHGA, ENO2
13cyclophosphamide44 49 1111.8CHGA, PTHLH, THBD, MCL1, CGB5, CSF3
14formaldehyde44 2410.8SYP, CHGA, KRT7, ENO2, KRT19, NKX2-1
1512-o-tetradecanoylphorbol 13-acetate449.8UCHL1, BAK1, MCL1, CHGA, PTHLH
16matrigel449.7CHGA, PTHLH, KRT7, KRT19, THBD
17glycogen44 2410.7STK11, SYP, CGB5, PTHLH, KRT7, MCL1
18cyclic amp44 2410.7CHGA, SYP, NKX2-1, CGB5, STK11, PTHLH
19ribonucleic acid449.7NKX2-1, CHGA, PTHLH, KRT19, ENO2, CGB5
20ibmx44 28 5911.7THBD, CGB5, PTHLH, ENO2
21dmso449.7ENO2, CSF3, CGB5, CHGA, BAK1, THBD
22nifedipine44 49 28 1112.7CHGA, THBD, CGB5, PTHLH
23methotrexate44 49 1111.6KRT7, ENO2, CSF3, CEACAM3, CGB5
24paclitaxel44 49 1111.6KRT19, MCL1, BAK1, CHGA, CGB5, CSF3
25b 723449.6THBD, CHGA, NKX2-1, SYP, CEACAM3, KRT7
26norepinephrine44 11 2411.6PTHLH, ENO2, CGB5, CHGA, SYP
27etoposide44 49 59 1112.6ENO2, CSF3, SYP, CHGA, BAK1, MCL1
28superoxide44 2410.6UCHL1, ENO2, CSF3, CGB5, SYP, BAK1
29hematoxylin449.6KRT7, ENO2, CEACAM3, CHGA, SYP, NKX2-1
30fibrinogen449.5CEACAM3, CHGA, THBD, CGB5, KRT19
31forskolin44 49 1111.5CHGA, PTHLH, THBD, MCL1, SYP, NKX2-1
32creatinine449.5KRT19, THBD, CEACAM3, PTHLH, CHGA, SYP
33streptavidin449.5KRT7, CGB5, CEACAM3
34steroid449.5NKX2-1, CGB5, CEACAM3, PTHLH, KRT19, THBD
35aspartate449.4THBD, KRT19, ENO2, CEACAM3, MCL1, PDGFRA
36thymidine44 2410.4PTHLH, KRT19, CSF3, PDGFRA, CEACAM3, ENO2
37testosterone44 59 11 2412.4ENO2, PTHLH, KRT7, KRT19, SYP, CHGA
38lactate449.4THBD, KRT19, CGB5, PTHLH, CEACAM3, CHGA
39nitric oxide44 11 2411.3BAK1, CGB5, CEACAM3, ENO2, THBD, PTHLH
40atp44 2810.3CHGA, ENO2, CGB5, PDGFRA, PTHLH, KRT19
41lipid449.2STK11, CGB5, SYP, CHGA, MCL1, THBD
42glucose449.2BAK1, THBD, CGB5, STK11, PTHLH, KRT19
43cisplatin44 49 59 1112.1CGB5, CSF3, SYP, CHGA, BAK1, ENO2
44progesterone44 59 28 11 2413.0ENO2, CEACAM3, KRT7, KRT19, THBD, CHGA
45oxygen44 249.9MCL1, PTHLH, S100A7, STK11, KRT19, CGB5
46vegf448.4CGB5, PDGFRA, MCL1, THBD, KRT19, KRT7
47paraffin448.3STK11, NKX2-1, THBD, PDGFRA, CEACAM3, ENO2
48retinoic acid44 249.3CSF3, PDGFRA, S100A7, CGB5, NKX2-1, THBD
49calcium44 49 11 2411.2MCL1, BAK1, DSC3, KRT19, DSC2, CHGA
50tyrosine448.1PDGFRA, CEACAM3, PTHLH, KRT19, BAK1, THBD

GO Terms for genes affiliated with Large Cell Carcinoma

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16Gene Ontology
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Biological processes related to Large Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Leydig cell differentiationGO:03332710.2NKX2-1, PDGFRA
2negative regulation of platelet activationGO:0105449.8THBD, PDGFRA

Products for genes affiliated with Large Cell Carcinoma

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Large Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet