MCID: LRG001
MIFTS: 53

Large Cell Carcinoma malady

Cancer diseases category

Summaries for Large Cell Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A carcinoma that is composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm.

MalaCards: Large Cell Carcinoma, also known as large cell carcinoma nos, is related to adenocarcinoma and lung adenocarcinoma. An important gene associated with Large Cell Carcinoma is NKX2-1 (NK2 homeobox 1), and among its related pathways is Neuroscience. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include lung, cervix and colon, and related mouse phenotypes are renal/urinary system and integument.

Wikipedia:63 Large-cell lung carcinoma (LCLC) is a heterogeneous group of undifferentiated malignant neoplasms... more...

Aliases & Classifications for Large Cell Carcinoma

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

large cell carcinoma 8
large cell carcinoma nos 8
carcinoma, large cell 60
carcinoma large cell 44


External Ids:

Disease Ontology8 DOID:4552
MeSH34 D018287
SNOMED-CT56 189551005, 22687000
NCIt39 C3780

Related Diseases for Large Cell Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Basal Cell Carcinoma family:

Small Cell Carcinoma large cell carcinoma
Cell Type Benign Neoplasm Cell Type Cancer
Basal Cell Carcinoma, Multiple Basal Cell Carcinoma 1
Basal Cell Carcinoma 2 Basal Cell Carcinoma 3
Basal Cell Carcinoma 6 Basal Cell Carcinoma 5
Basal Cell Carcinoma 4 Basal Cell Carcinoma 7

Diseases related to Large Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 173)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.0NKX2-1, KRT7, CEACAM3, ENO2, PTHLH, KRT19
2lung adenocarcinoma30.9KRT7, KRT19, STK11, THBD, NKX2-1, CEACAM3
3lung squamous cell carcinoma30.9KRT19, PTHLH
4squamous cell carcinoma30.8S100A7, CEACAM3, ENO2, PTHLH, KRT7, KRT19
5neuroendocrine carcinoma30.8CHGA, ENO2, KRT7, SYP, KRT19, NKX2-1
6lung small cell carcinoma30.6NKX2-1, SYP, CHGA, KRT7, PTHLH, ENO2
7bronchogenic carcinoma30.5KRT19, ENO2
8lung cancer30.3KRT19, UCHL1, PDGFRA, MCL1, PTHLH, NKX2-1
9neuroendocrine tumor30.2CHGA, ENO2, KRT19, CEACAM3, SYP, NKX2-1
10hypoglycemia29.9CHGA, STK11
11bladder carcinoma29.9KRT19, CGB5
12hypercalcemia29.9PTHLH, CHGA
13signet ring cell adenocarcinoma29.9KRT7, CHGA
14adenoid cystic carcinoma29.9KRT19, KRT7, CEACAM3
15adenosquamous carcinoma29.9CHGA, NKX2-1, KRT7, PTHLH, KRT19
16melanoma29.9STK11, CEACAM3, PDGFRA, NKX2-1, ENO2, MCL1
17lung large cell carcinoma11.0
18small cell carcinoma10.4
19large cell carcinoma with rhabdoid phenotype10.4
20pulmonary large cell neuroendocrine carcinoma10.3
21adrenal carcinoma10.3
22thymus large cell carcinoma10.3
23lung occult large cell carcinoma10.2
24pleomorphic carcinoma10.1
25lung giant cell carcinoma10.1
26intussusception10.1
27large cell keratinizing variant squamous cell breast carcinoma10.1
28duodenitis10.1
29thymic carcinoma10.1
30thyroiditis10.1
31hemangioma10.0NKX2-1
32respiratory failure10.0NKX2-1
33stomatitis10.0CSF3
34ductal carcinoma in situ10.0S100A7
35phaeochromocytoma10.0CHGA
36meningioma10.0SYP
37rhabdoid tumor10.0SYP
38gastritis10.0CHGA
39hypothyroidism10.0NKX2-1
40graves' disease10.0NKX2-1
41sertoli-leydig cell tumor10.0KRT7
42hemopneumothorax10.0
43lung mixed small cell and squamous cell carcinoma10.0
44lung carcinoma in situ10.0
45clear cell adenocarcinoma10.0
46systemic lupus erythematosus10.0
47spindle cell carcinoma10.0
48bladder signet ring cell adenocarcinoma10.0
49gynecomastia10.0
50lung adenoid cystic carcinoma10.0

Graphical network of the top 20 diseases related to Large Cell Carcinoma:



Diseases related to large cell carcinoma

Clinical Features for Large Cell Carcinoma

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Drugs & Therapeutics for Large Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Large Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Large Cell Carcinoma

Search NIH Clinical Center for Large Cell Carcinoma

Search CenterWatch for Large Cell Carcinoma

Genetic Tests for Large Cell Carcinoma

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Anatomical Context for Large Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Large Cell Carcinoma:

32
Lung, Cervix, Colon, Ovary, Thymus, Prostate, Breast, Thyroid, Liver, B cells, Brain, Kidney, Endothelial, Lymph node, Pancreas, Skin, T cells, Small intestine, Skeletal muscle, Tongue

Animal Models for Large Cell Carcinoma or affiliated genes

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36MGI
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Publications for Large Cell Carcinoma

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50PubMed
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Articles related to Large Cell Carcinoma:

(show top 50)    (show all 424)
idTitleAuthorsYear
1
Mixed large cell neuroendocrine carcinoma with squamous cell carcinoma of the rectum: Report of a rare case and review of the literature. (24240071)
2013
2
Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder: a case report. (23379295)
2013
3
Pathologic diagnosis of large cell neuroendocrine carcinoma of the lung in an axillary lymph node: a case report with immunohistochemical and molecular genetic studies. (23696939)
2013
4
Combined large cell neuroendocrine carcinoma with giant cell carcinoma of the lungs: a case report. (23957954)
2013
5
Large cystic renal cell carcinoma leading to diagnostic dilemma: a case report. (24426529)
2013
6
A case of the large cell neuroendocrine carcinoma of the urinary bladder. (23653657)
2013
7
TrkB/BDNF signaling pathway is a potential therapeutic target for pulmonary large cell neuroendocrine carcinoma. (23312550)
2013
8
Heterogeneity of ERBB2 amplification in adenocarcinoma, squamous cell carcinoma and large cell undifferentiated carcinoma of the lung. (22899293)
2012
9
Hypereosinophilia driven by GM-CSF in large-cell carcinoma of the lung. (22420949)
2012
10
Anti-HuC and -HuD autoantibodies are differential sero-diagnostic markers for small cell carcinoma from large cell neuroendocrine carcinoma of the lung. (22426972)
2012
11
Large cell neuroendocrine carcinoma of the thymus: a two-case report. (22363912)
2012
12
Pulmonary large cell neuroendocrine carcinoma diagnosed in a brain metastasis. (22400077)
2012
13
Combined large cell neuroendocrine carcinoma and spindle cell carcinoma of the lung. (21415004)
2011
14
Classification of large cell neuroendocrine carcinoma: at the cross roads of small and non-small cell lung cancer. (21847046)
2011
15
Large cystic acinar cell carcinoma of the pancreas. (20936304)
2011
16
Spontaneous complete regression of gastric large-cell neuroendocrine carcinoma: mediated by cytomegalovirus-induced cross-autoimmunity? (21665860)
2011
17
Large cell neuroendocrine carcinoma of the lung metastatic to the cauda equina. (20494806)
2010
18
Large-cell neuroendocrine carcinoma of the kidney: Clinicopathologic features. (19672368)
2009
19
Large-scale real-time reverse transcription-PCR approach of angiogenic pathways in human transitional cell carcinoma of the bladder: identification of VEGFA as a major independent prognostic marker. (18513850)
2009
20
Large cell carcinoma of the lung: an endangered species? (19444077)
2009
21
Desmocollin-3: a new marker of squamous differentiation in undifferentiated large-cell carcinoma of the lung. (19287461)
2009
22
Prostatic metastasis of large cell neuroendocrine carcinoma of the lung. (19659656)
2009
23
Immunocytochemical evaluation of large cell neuroendocrine carcinoma of the lung. (19248553)
2009
24
Cutaneous metastasis from large-cell neuroendocrine carcinoma of the urinary bladder expressing CK20 and TTF-1. (19318803)
2009
25
Paraneoplastic neuromuscular disease in lung large cell neuroendocrine carcinoma. (18973075)
2008
26
Neuroendocrine carcinomas (carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma): current concepts. (17548031)
2007
27
A long-term survivor with pulmonary large-cell neuroendocrine carcinoma. (17706407)
2007
28
Lung large cell carcinoma producing granulocyte-colony-stimulating factor. (17184692)
2007
29
Small cell carcinoma of the large bowel: a rare, but very aggressive malignancy. (17032213)
2006
30
LKB1 mutation in large cell carcinoma of the lung. (16822578)
2006
31
Large cell neuroendocrine thymic carcinoma coexisting within large WHO type AB thymoma. (16813109)
2006
32
Multiple metastases to the small bowel from large cell bronchial carcinomas. (15761985)
2005
33
Cytological characteristics of pulmonary large cell neuroendocrine carcinoma. (15893001)
2005
34
Large cell carcinoma of the lung mimicking a germ cell tumor: the potential value of chromosome analysis. (16022922)
2005
35
Undifferentiated large cell carcinoma of the thymus associated with Castleman disease-like reaction: a distinctive type of thymic neoplasm characterized by an indolent behavior. (15767803)
2005
36
Cigarette smoking and risk of large cell carcinoma of the lung: a case-control study in Uruguay. (15165084)
2004
37
Hemopneumothorax and hemoperitoneum in a case with large cell carcinoma of the lung. (10793500)
2000
38
Evidence for in situ expansion of diverse antitumor-specific cytotoxic T lymphocyte clones in a human large cell carcinoma of the lung. (10744655)
2000
39
The establishment of sublines with opposite chemosensitivity from a patient with pulmonary large cell carcinoma and the implementation of treatment based on tumor heterogeneity. (10554325)
1999
40
A phase I/II study to evaluate accelerated fractionation via concomitant boost for squamous, adeno, and large cell carcinoma of the lung: report of Radiation Therapy Oncology Group 84-07. (8390420)
1993
41
Large-cell carcinoma of the lung. With major bleeding and intussusception. (1328355)
1992
42
Establishment and characterization of a cell line, KaMi, from human lung large cell carcinoma. (1279943)
1992
43
A phase II trial of TCNU in patients with squamous, adeno and large cell carcinoma of the lung. (2561100)
1989
44
Uptake of Tc-99m MDP by adrenal metastases from undifferentiated large-cell carcinoma of the lung. (2551556)
1989
45
Negative phase II trial of menogaril in advanced squamous, adeno- and large cell carcinoma of the lung. (2833403)
1988
46
Large cell carcinoma of the lung. Ultrastructural and immunohistochemical features. (2428562)
1986
47
Ftorafur, adriamycin and mitomycin C (FAM II) for extensive bronchogenic adenocarcinoma and large cell carcinoma. (6323790)
1984
48
Phase II trial of epirubicin in advanced squamous, adeno- and large cell carcinoma of the lung. (6327315)
1984
49
Randomized trial of thoracic irradiation plus combination chemotherapy for unresectable adenocarcinoma and large cell carcinoma of the lung. (231024)
1979
50
Hexamethylmelamine, bleomycin, and CCNU chemotherapy for patients with squamous cell carcinoma, large cell carcinoma, and adenocarcinoma of the lung unresponsive to cyclophosphamide, adriamycin, methotrexate, and procarbazine. (77725)
1978

Genetic Variations for Large Cell Carcinoma

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Expression for genes affiliated with Large Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Large Cell Carcinoma

Search GEO for disease gene expression data for Large Cell Carcinoma.

Pathways for genes affiliated with Large Cell Carcinoma

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4Cell Signaling Technology
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Pathways related to Large Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9ENO2, SYP, NKX2-1, UCHL1

Compounds for genes affiliated with Large Cell Carcinoma

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44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience
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Compounds related to Large Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7S100A7
2cycloheximide4410.6CGB5
3s 1004410.3SYP, CHGA, ENO2
4smcc4410.2SYP, CHGA, KRT19, ENO2
5mucicarmine4410.1NKX2-1, SYP, KRT7, CEACAM3
6gossypol4410.1MCL1, BAK1, CGB5
7l-amino acid4410.1ENO2, CHGA, SYP
85-hydroxyindoleacetic acid44 2411.1CHGA, ENO2, CEACAM3
9serine4410.0UCHL1, STK11, NKX2-1, SYP, KRT19
10dexamethasone44 49 28 1112.9CGB5, NKX2-1, BAK1, MCL1, ENO2
11dbc-amp449.9CGB5, SYP, THBD, PTHLH, ENO2
12acth449.8CGB5, SYP, CHGA, ENO2, CEACAM3
13cyclophosphamide44 49 1111.8CSF3, CGB5, CHGA, MCL1, THBD, PTHLH
14formaldehyde44 2410.8NKX2-1, SYP, CHGA, KRT19, KRT7, ENO2
1512-o-tetradecanoylphorbol 13-acetate449.8PTHLH, MCL1, BAK1, CHGA, UCHL1
16matrigel449.7CHGA, THBD, KRT19, KRT7, PTHLH
17glycogen44 2410.7STK11, CGB5, SYP, CHGA, MCL1, KRT7
18cyclic amp44 2410.7STK11, CGB5, NKX2-1, SYP, CHGA, MCL1
19ribonucleic acid449.7CGB5, NKX2-1, CHGA, KRT19, PTHLH, ENO2
20ibmx44 28 5911.7ENO2, PTHLH, THBD, CGB5
21dmso449.7CSF3, CGB5, CHGA, BAK1, THBD, ENO2
22nifedipine44 49 28 1112.7CGB5, CHGA, THBD, PTHLH
23methotrexate44 49 1111.6CSF3, CGB5, KRT7, ENO2, CEACAM3
24paclitaxel44 49 1111.6CSF3, CGB5, CHGA, BAK1, MCL1, KRT19
25b 723449.6CEACAM3, KRT7, KRT19, THBD, CHGA, SYP
26norepinephrine44 11 2411.6CGB5, SYP, CHGA, PTHLH, ENO2
27etoposide44 49 59 1112.6CSF3, CGB5, SYP, CHGA, BAK1, MCL1
28superoxide44 2410.6UCHL1, CSF3, CGB5, SYP, BAK1, ENO2
29hematoxylin449.6NKX2-1, SYP, CHGA, KRT19, KRT7, ENO2
30fibrinogen449.5CGB5, CHGA, THBD, KRT19, CEACAM3
31forskolin44 49 1111.5CGB5, NKX2-1, SYP, CHGA, MCL1, THBD
32creatinine449.5CGB5, SYP, CHGA, THBD, KRT19, PTHLH
33streptavidin449.5CEACAM3, KRT7, CGB5
34steroid449.5CGB5, NKX2-1, SYP, THBD, KRT19, PTHLH
35aspartate449.4CEACAM3, ENO2, KRT19, THBD, MCL1, PDGFRA
36thymidine44 2410.4PDGFRA, CSF3, KRT19, PTHLH, ENO2, CEACAM3
37testosterone44 59 11 2412.4CGB5, SYP, CHGA, KRT19, KRT7, PTHLH
38lactate449.4CGB5, CHGA, THBD, KRT19, PTHLH, ENO2
39nitric oxide44 11 2411.3CGB5, SYP, CHGA, BAK1, THBD, PTHLH
40atp44 2810.3PDGFRA, STK11, CGB5, CHGA, THBD, KRT19
41lipid449.2STK11, CGB5, SYP, CHGA, MCL1, THBD
42glucose449.2STK11, CGB5, BAK1, THBD, KRT19, KRT7
43cisplatin44 49 59 1112.1CSF3, CGB5, SYP, CHGA, BAK1, MCL1
44progesterone44 59 28 11 2413.0CGB5, NKX2-1, SYP, CHGA, THBD, KRT19
45oxygen44 249.9S100A7, STK11, CGB5, CHGA, BAK1, MCL1
46vegf448.4CSF3, PDGFRA, STK11, CGB5, CEACAM3, ENO2
47retinoic acid44 249.3ENO2, S100A7, PTHLH, KRT7, KRT19, THBD
48paraffin448.3PTHLH, KRT7, KRT19, THBD, MCL1, BAK1
49calcium44 49 11 2411.2S100A7, PDGFRA, STK11, CGB5, SYP, CHGA
50tyrosine448.1SYP, NKX2-1, CGB5, CSF3, PDGFRA, UCHL1

GO Terms for genes affiliated with Large Cell Carcinoma

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16Gene Ontology
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Biological processes related to Large Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Leydig cell differentiationGO:03332710.2NKX2-1, PDGFRA
2negative regulation of platelet activationGO:0105449.8THBD, PDGFRA

Products for genes affiliated with Large Cell Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Large Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet