MCID: LRG001
MIFTS: 49

Large Cell Carcinoma malady

Cancer diseases, Skin diseases, Rare diseases categories

Summaries for Large Cell Carcinoma

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A carcinoma that is composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm.

MalaCards: Large Cell Carcinoma, also known as large cell carcinoma nos, is related to adenocarcinoma and neuroendocrine carcinoma. An important gene associated with Large Cell Carcinoma is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways is Neuroscience. The compounds smcc and 111in-pentetreotide have been mentioned in the context of this disorder. Affiliated tissues include lung, thyroid and brain, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Wikipedia:66 Large-cell lung carcinoma (LCLC) is a heterogeneous group of undifferentiated malignant neoplasms... more...

Aliases & Classifications for Large Cell Carcinoma

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9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Skin diseases


Aliases & Descriptions:

large cell carcinoma 9
large cell carcinoma nos 9
carcinoma, large cell 63
carcinoma large cell 46


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Disease Ontology9 DOID:4552
MeSH36 D018287
SNOMED-CT59 22687000, 189551005
NCIt41 C3780

Related Diseases for Large Cell Carcinoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Basal Cell Carcinoma family:

large cell carcinoma Small Cell Carcinoma
Cell Type Benign Neoplasm Cell Type Cancer
Basal Cell Carcinoma, Multiple Basal Cell Carcinoma 1
Basal Cell Carcinoma 2 Basal Cell Carcinoma 3
Basal Cell Carcinoma 6 Basal Cell Carcinoma 5
Basal Cell Carcinoma 4 Basal Cell Carcinoma 7

Diseases related to Large Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.0CHGA, NKX2-1, SYP, STK11
2neuroendocrine carcinoma30.4CHGA, NKX2-1, SYP
3adenosquamous carcinoma30.1CHGA, NKX2-1
4hypoglycemia30.0CHGA, STK11
5melanoma29.9STK11, NKX2-1, PDGFRA
6lung large cell carcinoma10.5
7large cell carcinoma with rhabdoid phenotype10.3
8small cell carcinoma10.3
9lung occult large cell carcinoma10.3
10large cell neuroendocrine carcinoma10.3
11thymus large cell carcinoma10.3
12intussusception10.2
13large cell keratinizing variant squamous cell breast carcinoma10.2
14duodenitis10.2
15pleomorphic carcinoma10.2
16lung squamous cell carcinoma10.2
17pulmonary large cell neuroendocrine carcinoma10.2
18thyroiditis10.2
19neuroendocrine tumor10.1CHGA
20pulmonary blastoma10.1NKX2-1
21dysembryoplastic neuroepithelial tumor10.1SYP
22central neurocytoma10.1CHGA, SYP
23pancreatic islet cell tumors10.1CHGA, SYP
24endocrine gland cancer10.1CHGA, SYP
25pineocytoma10.1SYP, CHGA
26tubular adenocarcinoma10.1SYP, CHGA
27ganglioglioma10.1CHGA, SYP
28gastrinoma10.0CHGA, SYP
29thyroid medullary carcinoma10.0NKX2-1, CHGA
30ganglioneuroma10.0CHGA, SYP
31thymus cancer10.0NKX2-1, SYP
32paraganglioma10.0SYP, CHGA
33adrenocortical carcinoma10.0CHGA, SYP
34adrenal adenoma10.0SYP, CHGA
35cushing's syndrome10.0SYP, CHGA
36neurofibroma10.0PDGFRA, SYP
37ependymoma10.0PDGFRA, SYP
38peripheral primitive neuroectodermal tumor10.0PDGFRA, CHGA
39thyroid cancer10.0CHGA, NKX2-1
40pancreatic cancer10.0CHGA, SYP
41oligodendroglioma10.0SYP, PDGFRA
42teratocarcinoma10.0PDGFRA, SYP
43neuroblastoma10.0SYP
44lung mixed small cell and squamous cell carcinoma10.0
45hemopneumothorax10.0
46gynecomastia10.0
47hypercalcemia10.0
48adenoiditis10.0
49systemic lupus erythematosus10.0
50adenoid cystic carcinoma10.0

Graphical network of the top 20 diseases related to Large Cell Carcinoma:



Diseases related to large cell carcinoma

Symptoms for Large Cell Carcinoma

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Drugs & Therapeutics for Large Cell Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Large Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Large Cell Carcinoma

Search NIH Clinical Center for Large Cell Carcinoma

Search CenterWatch for Large Cell Carcinoma

Genetic Tests for Large Cell Carcinoma

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Anatomical Context for Large Cell Carcinoma

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Sources:
34MalaCards
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MalaCards organs/tissues related to Large Cell Carcinoma:

34
Lung, Thyroid, Brain, Ovary, Lymph node, Thymus, Small intestine, Prostate

Animal Models for Large Cell Carcinoma or affiliated genes

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38MGI
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Publications for Large Cell Carcinoma

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53PubMed
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Articles related to Large Cell Carcinoma:

(show top 50)    (show all 149)
idTitleAuthorsYear
1
Pulmonary Large Cell Carcinoma Lacking Squamous Differentiation Is Clinicopathologically Indistinguishable From Solid-Subtype Adenocarcinoma. (23738762)
2013
2
Distinct profile of driver mutations and clinical features in immunomarker-defined subsets of pulmonary large-cell carcinoma. (23196793)
2013
3
Mixed squamous and large-cell carcinoma of the lung: a case study and literature review. (23174733)
2012
4
Pulmonary large cell carcinoma mimicking an infected thoracoabdominal aortic aneurysm. (21847044)
2011
5
Cystic tumors of the right atrium caused by nonbacterial thrombotic endocarditis in a patient with large cell carcinoma. (19420823)
2009
6
Large cell carcinoma of the lung and squamous cell carcinoma of the oropharynx presenting as uveitis. (19413230)
2009
7
Humoral hypercalcemia of malignancy in a patient with large cell carcinoma of the lung: report of case and review of literature. (17669716)
2007
8
Identification of HLA-A24 restricted shared antigen recognized by autologous cytotoxic T lymphocytes from a patient with large cell carcinoma of the lung. (17131342)
2007
9
A case of large cell carcinoma of the lung with rhabdoid phenotype]. (16681249)
2006
10
Lymph node metastasis of large-cell carcinoma of the lung in a seventeen-year-old patient: diagnosis by fine-needle aspiration. (17115438)
2006
11
Large cell carcinoma with neuroendocrine morphology of the lung. (16482935)
2006
12
Bilateral adrenal metastases from large cell carcinoma of lung in a female non-smoker patient. (16912999)
2006
13
Large cell neuroendocrine carcinoma of the lung: a comparison with large cell carcinoma with neuroendocrine morphology and small cell carcinoma. (15639721)
2005
14
Pulmonary large cell carcinoma with rhabdoid phenotype. (16084457)
2005
15
Solitary adrenal metastasis in large cell carcinoma of lung. (15558361)
2004
16
Cigarette smoking and risk of large cell carcinoma of the lung: a case-control study in Uruguay. (15165084)
2004
17
Immunohistochemical neuroendocrine differentiation is an independent prognostic factor in surgically resected large cell carcinoma of the lung. (12399130)
2002
18
Sarcoid reaction in primary tumor of bronchogenic large cell carcinoma accompanied with massive necrosis. (11300145)
2001
19
Long-term survival of a patient with stage IV pulmonary large cell carcinoma achieved by combined-modality therapy: report of a case. (10883474)
2000
20
Hemopneumothorax and hemoperitoneum in a case with large cell carcinoma of the lung. (10793500)
2000
21
Bronchial arterial infusion with cisplatin followed by irradiation successfully treats recurrent stage IVb thymic large cell carcinoma. (10571098)
1999
22
Large cell carcinoma of the lung: results of resection for a cure. (10047666)
1999
23
Spontaneous regression of large-cell carcinoma of the lung--a rare observation in clinical practice. (10218623)
1999
24
Large cell carcinoma of the lung metastatic to nuchal muscle. (9525301)
1997
25
High-dose tamoxifen reverses drug resistance to cisplatin and etoposide in a patient with advanced large cell carcinoma of lung. (9137495)
1997
26
Phase II trial of carboplatin in combination with etoposide in locally advanced large cell carcinoma and adenocarcinoma of the lung. (7655835)
1995
27
Large-cell carcinoma of the lung. With major bleeding and intussusception. (1328355)
1992
28
A case of hCG-producing large cell carcinoma of the lung--clinical utility of serum hCG levels]. (1321306)
1992
29
Large cell carcinoma of the lung secreting human chorionic gonadotropin which responded to combination chemotherapy: case report. (2174998)
1990
30
Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung. (2567993)
1989
31
Large cell carcinoma of the lung: a highly aggressive tumor with dismal prognosis. (2547348)
1989
32
Karyotypic evolution of a human undifferentiated large cell carcinoma of the lung in tissue culture. (2720688)
1989
33
Establishment of a G-CSF and GM-CSF producing cell line from human large cell carcinoma of the lung. (2477274)
1989
34
A phase II trial of TCNU in patients with squamous, adeno and large cell carcinoma of the lung. (2561100)
1989
35
Natural history of adenocarcinoma-large cell carcinoma of the lung: conclusions from screening programs in New York and Baltimore. (2833601)
1988
36
Large cell carcinoma of the lung--ultrastructural and immunohistochemical studies. (2410641)
1985
37
Comparison of combination chemotherapy programs in advanced adenocarcinoma-large cell carcinoma of the lung: a North Central Cancer Treatment Group study. (6322987)
1984
38
Bilateral diffuse malignant melanoma of the uvea associated with large cell carcinoma, giant cell type, of the lung. Case report of a newly described syndrome. (6096784)
1984
39
Ftorafur, adriamycin and mitomycin C (FAM II) for extensive bronchogenic adenocarcinoma and large cell carcinoma. (6323790)
1984
40
Vindesine in the treatment of squamous cell carcinoma (WHO I), adenocarcinoma (WHO III), and large cell carcinoma (WHO IV) of the lung. (6301122)
1982
41
Vindesine in the treatment of squamous cell carcinoma, adenocarcinoma, and large cell carcinoma of the lung. (7055816)
1982
42
Radiotherapy of squamous, adeno- and large cell carcinoma of the lung. (6279292)
1982
43
Ultrastructural features of large cell carcinoma of the lung with reference to the prognosis of patients. (7250954)
1981
44
Human chorionic gonadotropin-secreting large cell carcinoma of the lung detected during follow-up of a patient previously treated for gestational trophoblastic disease. (6249700)
1980
45
Combination chemotherapy with mitomycin C, adriamycin, and cyclophosphamide in advanced adenocarcinoma and large cell carcinoma of the lung. (230896)
1979
46
Mitomycin C in advanced adenocarcinoma and large cell carcinoma of the lung. (203393)
1978
47
Hexamethylmelamine, bleomycin, and CCNU chemotherapy for patients with squamous cell carcinoma, large cell carcinoma, and adenocarcinoma of the lung unresponsive to cyclophosphamide, adriamycin, methotrexate, and procarbazine. (77725)
1978
48
Large-cell carcinoma metastatic to the jaw. Report of a case. (269332)
1977
49
Mechlorethamine (NSC-762) plus CCNU (NSC-79037) in the treatment of inoperable squamous and large cell carcinoma of the lung. (186183)
1976
50
The roentgenographic appearance of large cell carcinoma of the bronchus. (5647726)
1968

Variations for Large Cell Carcinoma

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Expression for genes affiliated with Large Cell Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Large Cell Carcinoma

Search GEO for disease gene expression data for Large Cell Carcinoma.

Pathways for genes affiliated with Large Cell Carcinoma

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51PathCards, 5Cell Signaling Technology
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Pathways related to Large Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.7NKX2-1, UCHL1, SYP

Compounds for genes affiliated with Large Cell Carcinoma

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Sources:
46Novoseek, 52PharmGKB, 30IUPHAR, 3BitterDB, 12DrugBank, 25HMDB, 62Tocris Bioscience
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Compounds related to Large Cell Carcinoma according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1smcc469.9CHGA, SYP
2111in-pentetreotide469.9CHGA, SYP
3s 100469.9CHGA, SYP
4l-amino acid469.8CHGA, SYP
5mucicarmine469.8NKX2-1, SYP
6streptozotocin469.8CHGA, SYP
7silver469.8CHGA, SYP
8amine469.7SYP, CHGA
9haloperidol46 52 30 3 1213.6CHGA, SYP
10catecholamine469.5SYP, CHGA
115-hydroxytryptamine469.5SYP, CHGA
12b 723469.5CHGA, SYP, NKX2-1
13hematoxylin469.5NKX2-1, SYP, CHGA
14formaldehyde46 2510.4NKX2-1, SYP, CHGA
15forskolin46 52 1211.4CHGA, SYP, NKX2-1
16progesterone46 30 62 25 1213.3NKX2-1, SYP, CHGA
17steroid469.3NKX2-1, SYP, CHGA
18guanine46 25 1211.3SYP, STK11, CHGA
19gold469.2SYP, CHGA
20oligonucleotide469.2CHGA, NKX2-1, PDGFRA
21glycogen46 2510.2SYP, STK11, CHGA
22dexamethasone46 52 30 1212.2NKX2-1, SYP, CHGA
23dopamine46 30 25 1212.0UCHL1, SYP, CHGA
24estrogen468.9CHGA, SYP, NKX2-1, PDGFRA
25retinoic acid46 259.9PDGFRA, NKX2-1, SYP, CHGA
26cyclic amp46 259.8NKX2-1, SYP, STK11, CHGA
27vegf468.7CHGA, STK11, SYP, PDGFRA
28paraffin468.3PDGFRA, NKX2-1, SYP, STK11, CHGA
29calcium46 52 25 1211.3CHGA, STK11, SYP, PDGFRA
30tyrosine468.1PDGFRA, NKX2-1, UCHL1, SYP, CHGA
31serine468.0CHGA, STK11, SYP, UCHL1, NKX2-1

GO Terms for genes affiliated with Large Cell Carcinoma

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17Gene Ontology
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Biological processes related to Large Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Leydig cell differentiationGO:0333279.4PDGFRA, NKX2-1
2protein autophosphorylationGO:0467779.3PDGFRA, STK11
3lung developmentGO:0303249.2PDGFRA, NKX2-1

Products for genes affiliated with Large Cell Carcinoma

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  • Antibodies
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  • Lysates
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Sources for Large Cell Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet