MCID: LRG001
MIFTS: 49

Large Cell Carcinoma malady

Cancer diseases, Skin diseases, Rare diseases categories
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Summaries for Large Cell Carcinoma

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Disease Ontology:8 A carcinoma that is composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm.

MalaCards based summary: Large Cell Carcinoma, also known as carcinoma, large cell, is related to adenocarcinoma and neuroendocrine carcinoma. An important gene associated with Large Cell Carcinoma is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways is Neuroscience. The compounds smcc and 111in-pentetreotide have been mentioned in the context of this disorder. Affiliated tissues include lung, thyroid and lymph node, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Wikipedia:65 Large-cell lung carcinoma (LCLC) is a heterogeneous group of undifferentiated malignant neoplasms... more...

Aliases & Classifications for Large Cell Carcinoma

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt
See all sources

Large Cell Carcinoma, Aliases & Descriptions:

Name: Large Cell Carcinoma 8
Carcinoma, Large Cell 62
 
Carcinoma Large Cell 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:4552
MeSH34 D018287
SNOMED-CT57 22687000, 189551005
NCIt39 C3780

Related Diseases for Large Cell Carcinoma

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Diseases in the Basal Cell Carcinoma family:

large cell carcinoma Small Cell Carcinoma
Cell Type Benign Neoplasm Cell Type Cancer
Basal Cell Carcinoma, Multiple Basal Cell Carcinoma 1
Basal Cell Carcinoma 2 Basal Cell Carcinoma 3
Basal Cell Carcinoma 6 Basal Cell Carcinoma 5
Basal Cell Carcinoma 4 Basal Cell Carcinoma 7

Diseases related to Large Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.7CHGA, STK11, SYP, NKX2-1
2neuroendocrine carcinoma30.5NKX2-1, SYP, CHGA
3adenosquamous carcinoma30.4NKX2-1, CHGA
4hypoglycemia30.1STK11, CHGA
5melanoma29.7PDGFRA, NKX2-1, STK11
6lung large cell carcinoma10.5
7neuroendocrine tumor10.4CHGA
8pulmonary blastoma10.4NKX2-1
9dysembryoplastic neuroepithelial tumor10.4SYP
10large cell carcinoma with rhabdoid phenotype10.4
11lung occult large cell carcinoma10.3
12small cell carcinoma10.3
13large cell neuroendocrine carcinoma10.3
14thymus large cell carcinoma10.3
15central neurocytoma10.2SYP, CHGA
16pancreatic islet cell tumors10.2SYP, CHGA
17endocrine gland cancer10.2CHGA, SYP
18pineocytoma10.2CHGA, SYP
19tubular adenocarcinoma10.2SYP, CHGA
20ganglioglioma10.2CHGA, SYP
21gastrinoma10.2SYP, CHGA
22thyroid medullary carcinoma10.2NKX2-1, CHGA
23ganglioneuroma10.2SYP, CHGA
24thymus cancer10.2NKX2-1, SYP
25paraganglioma10.2SYP, CHGA
26adrenocortical carcinoma10.2SYP, CHGA
27adrenal cortical adenoma10.2SYP, CHGA
28cushing's syndrome10.2CHGA, SYP
29large cell keratinizing variant squamous cell breast carcinoma10.2
30pleomorphic carcinoma10.2
31intussusception10.2
32duodenitis10.2
33lung squamous cell carcinoma10.2
34pulmonary large cell neuroendocrine carcinoma10.2
35thyroiditis10.2
36neurofibroma10.2PDGFRA, SYP
37ependymoma10.2PDGFRA, SYP
38peripheral primitive neuroectodermal tumor10.2PDGFRA, CHGA
39thyroid hurthle cell carcinoma10.2CHGA, NKX2-1
40pancreatic cancer10.1SYP, CHGA
41oligodendroglioma10.1PDGFRA, SYP
42teratocarcinoma10.1SYP, PDGFRA
43neuroblastoma10.1SYP
44tuberous sclerosis10.1STK11, SYP
45pituitary adenoma10.1CHGA, SYP
46merkel cell carcinoma10.1CHGA, SYP, NKX2-1
47papillary carcinoma10.0NKX2-1, SYP, CHGA
48carcinoid syndrome10.0CHGA, SYP, NKX2-1
49systemic lupus erythematosus10.0
50lung mixed small cell and squamous cell carcinoma10.0

Graphical network of the top 20 diseases related to Large Cell Carcinoma:



Diseases related to large cell carcinoma

Symptoms for Large Cell Carcinoma

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Drugs & Therapeutics for Large Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Large Cell Carcinoma

Search NIH Clinical Center for Large Cell Carcinoma

Genetic Tests for Large Cell Carcinoma

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Anatomical Context for Large Cell Carcinoma

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MalaCards organs/tissues related to Large Cell Carcinoma:

32
Lung, Thyroid, Lymph node, Brain, Small intestine, Ovary, Prostate

Animal Models for Large Cell Carcinoma or affiliated genes

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Publications for Large Cell Carcinoma

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Articles related to Large Cell Carcinoma:

(show top 50)    (show all 150)
idTitleAuthorsYear
1
Large-cell carcinoma of the lung: a diagnostic category redefined by immunohistochemistry and genomics. (24811836)
2014
2
Pulmonary Large Cell Carcinoma Lacking Squamous Differentiation Is Clinicopathologically Indistinguishable From Solid-Subtype Adenocarcinoma. (23738762)
2013
3
Distinct profile of driver mutations and clinical features in immunomarker-defined subsets of pulmonary large-cell carcinoma. (23196793)
2013
4
Mixed squamous and large-cell carcinoma of the lung: a case study and literature review. (23174733)
2012
5
Pulmonary large cell carcinoma mimicking an infected thoracoabdominal aortic aneurysm. (21847044)
2011
6
Cystic tumors of the right atrium caused by nonbacterial thrombotic endocarditis in a patient with large cell carcinoma. (19420823)
2009
7
Large cell carcinoma of the lung and squamous cell carcinoma of the oropharynx presenting as uveitis. (19413230)
2009
8
Humoral hypercalcemia of malignancy in a patient with large cell carcinoma of the lung: report of case and review of literature. (17669716)
2007
9
Identification of HLA-A24 restricted shared antigen recognized by autologous cytotoxic T lymphocytes from a patient with large cell carcinoma of the lung. (17131342)
2007
10
A case of large cell carcinoma of the lung with rhabdoid phenotype]. (16681249)
2006
11
Lymph node metastasis of large-cell carcinoma of the lung in a seventeen-year-old patient: diagnosis by fine-needle aspiration. (17115438)
2006
12
Large cell carcinoma with neuroendocrine morphology of the lung. (16482935)
2006
13
Bilateral adrenal metastases from large cell carcinoma of lung in a female non-smoker patient. (16912999)
2006
14
Large cell neuroendocrine carcinoma of the lung: a comparison with large cell carcinoma with neuroendocrine morphology and small cell carcinoma. (15639721)
2005
15
Pulmonary large cell carcinoma with rhabdoid phenotype. (16084457)
2005
16
Solitary adrenal metastasis in large cell carcinoma of lung. (15558361)
2004
17
Cigarette smoking and risk of large cell carcinoma of the lung: a case-control study in Uruguay. (15165084)
2004
18
Immunohistochemical neuroendocrine differentiation is an independent prognostic factor in surgically resected large cell carcinoma of the lung. (12399130)
2002
19
Sarcoid reaction in primary tumor of bronchogenic large cell carcinoma accompanied with massive necrosis. (11300145)
2001
20
Long-term survival of a patient with stage IV pulmonary large cell carcinoma achieved by combined-modality therapy: report of a case. (10883474)
2000
21
Hemopneumothorax and hemoperitoneum in a case with large cell carcinoma of the lung. (10793500)
2000
22
Bronchial arterial infusion with cisplatin followed by irradiation successfully treats recurrent stage IVb thymic large cell carcinoma. (10571098)
1999
23
Large cell carcinoma of the lung: results of resection for a cure. (10047666)
1999
24
Spontaneous regression of large-cell carcinoma of the lung--a rare observation in clinical practice. (10218623)
1999
25
Large cell carcinoma of the lung metastatic to nuchal muscle. (9525301)
1997
26
High-dose tamoxifen reverses drug resistance to cisplatin and etoposide in a patient with advanced large cell carcinoma of lung. (9137495)
1997
27
Phase II trial of carboplatin in combination with etoposide in locally advanced large cell carcinoma and adenocarcinoma of the lung. (7655835)
1995
28
Large-cell carcinoma of the lung. With major bleeding and intussusception. (1328355)
1992
29
A case of hCG-producing large cell carcinoma of the lung--clinical utility of serum hCG levels]. (1321306)
1992
30
Large cell carcinoma of the lung secreting human chorionic gonadotropin which responded to combination chemotherapy: case report. (2174998)
1990
31
Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung. (2567993)
1989
32
Large cell carcinoma of the lung: a highly aggressive tumor with dismal prognosis. (2547348)
1989
33
Karyotypic evolution of a human undifferentiated large cell carcinoma of the lung in tissue culture. (2720688)
1989
34
Establishment of a G-CSF and GM-CSF producing cell line from human large cell carcinoma of the lung. (2477274)
1989
35
A phase II trial of TCNU in patients with squamous, adeno and large cell carcinoma of the lung. (2561100)
1989
36
Natural history of adenocarcinoma-large cell carcinoma of the lung: conclusions from screening programs in New York and Baltimore. (2833601)
1988
37
Large cell carcinoma of the lung--ultrastructural and immunohistochemical studies. (2410641)
1985
38
Comparison of combination chemotherapy programs in advanced adenocarcinoma-large cell carcinoma of the lung: a North Central Cancer Treatment Group study. (6322987)
1984
39
Bilateral diffuse malignant melanoma of the uvea associated with large cell carcinoma, giant cell type, of the lung. Case report of a newly described syndrome. (6096784)
1984
40
Vindesine in the treatment of squamous cell carcinoma (WHO I), adenocarcinoma (WHO III), and large cell carcinoma (WHO IV) of the lung. (6301122)
1982
41
Vindesine in the treatment of squamous cell carcinoma, adenocarcinoma, and large cell carcinoma of the lung. (7055816)
1982
42
Radiotherapy of squamous, adeno- and large cell carcinoma of the lung. (6279292)
1982
43
Ultrastructural features of large cell carcinoma of the lung with reference to the prognosis of patients. (7250954)
1981
44
Human chorionic gonadotropin-secreting large cell carcinoma of the lung detected during follow-up of a patient previously treated for gestational trophoblastic disease. (6249700)
1980
45
Combination chemotherapy with mitomycin C, adriamycin, and cyclophosphamide in advanced adenocarcinoma and large cell carcinoma of the lung. (230896)
1979
46
Mitomycin C in advanced adenocarcinoma and large cell carcinoma of the lung. (203393)
1978
47
Hexamethylmelamine, bleomycin, and CCNU chemotherapy for patients with squamous cell carcinoma, large cell carcinoma, and adenocarcinoma of the lung unresponsive to cyclophosphamide, adriamycin, methotrexate, and procarbazine. (77725)
1978
48
Large-cell carcinoma metastatic to the jaw. Report of a case. (269332)
1977
49
Mechlorethamine (NSC-762) plus CCNU (NSC-79037) in the treatment of inoperable squamous and large cell carcinoma of the lung. (186183)
1976
50
The roentgenographic appearance of large cell carcinoma of the bronchus. (5647726)
1968

Variations for Large Cell Carcinoma

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Expression for genes affiliated with Large Cell Carcinoma

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Expression patterns in normal tissues for genes affiliated with Large Cell Carcinoma

Search GEO for disease gene expression data for Large Cell Carcinoma.

Pathways for genes affiliated with Large Cell Carcinoma

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Pathways related to Large Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.7NKX2-1, UCHL1, SYP

Compounds for genes affiliated with Large Cell Carcinoma

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Compounds related to Large Cell Carcinoma according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1smcc449.9CHGA, SYP
2111in-pentetreotide449.9CHGA, SYP
3s 100449.9CHGA, SYP
4l-amino acid449.8CHGA, SYP
5mucicarmine449.8NKX2-1, SYP
6streptozotocin449.8CHGA, SYP
7silver449.8CHGA, SYP
8amine449.7SYP, CHGA
9haloperidol44 50 28 2 1113.6CHGA, SYP
10catecholamine449.5SYP, CHGA
115-hydroxytryptamine449.5SYP, CHGA
12b 723449.5CHGA, SYP, NKX2-1
13hematoxylin449.5NKX2-1, SYP, CHGA
14formaldehyde44 2410.4NKX2-1, SYP, CHGA
15forskolin44 50 1111.4CHGA, SYP, NKX2-1
16progesterone44 28 61 24 1113.3NKX2-1, SYP, CHGA
17steroid449.3NKX2-1, SYP, CHGA
18guanine44 24 1111.3SYP, STK11, CHGA
19gold449.2SYP, CHGA
20oligonucleotide449.2CHGA, NKX2-1, PDGFRA
21glycogen44 2410.2SYP, STK11, CHGA
22dexamethasone44 50 28 1112.2NKX2-1, SYP, CHGA
23dopamine44 28 24 1112.0UCHL1, SYP, CHGA
24estrogen448.9CHGA, SYP, NKX2-1, PDGFRA
25retinoic acid44 249.9PDGFRA, NKX2-1, SYP, CHGA
26cyclic amp44 249.8NKX2-1, SYP, STK11, CHGA
27vegf448.7CHGA, STK11, SYP, PDGFRA
28paraffin448.3PDGFRA, NKX2-1, SYP, STK11, CHGA
29calcium44 50 24 1111.3CHGA, STK11, SYP, PDGFRA
30tyrosine448.1PDGFRA, NKX2-1, UCHL1, SYP, CHGA
31serine448.0CHGA, STK11, SYP, UCHL1, NKX2-1

GO Terms for genes affiliated with Large Cell Carcinoma

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Biological processes related to Large Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Leydig cell differentiationGO:0333279.4PDGFRA, NKX2-1
2protein autophosphorylationGO:0467779.3PDGFRA, STK11
3lung developmentGO:0303249.2PDGFRA, NKX2-1

Products for genes affiliated with Large Cell Carcinoma

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  • Antibodies
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Sources for Large Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet