MCID: LRG001
MIFTS: 41

Large Cell Carcinoma malady

Genetic diseases, Cancer diseases, Respiratory diseases, Skin diseases, Rare diseases categories

Aliases & Classifications for Large Cell Carcinoma

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH
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Large Cell Carcinoma, Aliases & Descriptions:

Name: Large Cell Carcinoma 9
Carcinoma, Large Cell 60
 
Carcinoma Large Cell 43


Classifications:



External Ids:

Disease Ontology9 DOID:4552
NCIt38 C3780
SNOMED-CT55 22687000, 189551005
MeSH33 D018287

Summaries for Large Cell Carcinoma

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Disease Ontology:9 A carcinoma that is composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm.

MalaCards based summary: Large Cell Carcinoma, also known as carcinoma, large cell, is related to adenocarcinoma and adenosquamous carcinoma. An important gene associated with Large Cell Carcinoma is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways is Neuroscience. The compounds smcc and 111in-pentetreotide have been mentioned in the context of this disorder. Affiliated tissues include lung, thyroid and lymph node, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Related Diseases for Large Cell Carcinoma

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Diseases in the Large Cell Carcinoma family:

Basal Cell Carcinoma 7 Small Cell Carcinoma
Basal Cell Carcinoma Cell Type Benign Neoplasm
Cell Type Cancer Basal Cell Carcinoma, Multiple

Diseases related to Large Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.7CHGA, STK11, SYP, NKX2-1
2adenosquamous carcinoma30.4NKX2-1, CHGA
3thymic carcinoma30.4NKX2-1, SYP
4hypoglycemia30.1STK11, CHGA
5lung cancer29.7CHGA, STK11, SYP, NKX2-1
6melanoma29.7PDGFRA, NKX2-1, STK11
7lung large cell carcinoma10.6
8neuroendocrine tumor10.4CHGA
9pulmonary blastoma10.4NKX2-1
10large cell carcinoma with rhabdoid phenotype10.4
11dysembryoplastic neuroepithelial tumor10.4SYP
12lung occult large cell carcinoma10.3
13thymus large cell carcinoma10.3
14small cell carcinoma10.3
15neuroendocrine carcinoma10.3
16large cell neuroendocrine carcinoma10.3
17lung squamous cell carcinoma10.3
18central neurocytoma10.2SYP, CHGA
19islet cell tumor10.2SYP, CHGA
20endocrine gland cancer10.2CHGA, SYP
21pineocytoma10.2CHGA, SYP
22tubular adenocarcinoma10.2SYP, CHGA
23ganglioglioma10.2CHGA, SYP
24gastrinoma10.2SYP, CHGA
25medullary thyroid carcinoma, familial10.2NKX2-1, CHGA
26ganglioneuroma10.2SYP, CHGA
27paraganglioma10.2SYP, CHGA
28adrenocortical carcinoma10.2SYP, CHGA
29adrenal cortical adenoma10.2SYP, CHGA
30intussusception10.2
31large cell keratinizing variant squamous cell breast carcinoma10.2
32duodenitis10.2
33pleomorphic carcinoma10.2
34pulmonary large cell neuroendocrine carcinoma10.2
35thyroiditis10.2
36cushing's syndrome10.2CHGA, SYP
37neurofibroma10.2PDGFRA, SYP
38ependymoma10.2PDGFRA, SYP
39ewing sarcoma10.1PDGFRA, CHGA
40thyroid cancer10.1CHGA, NKX2-1
41pancreatic cancer10.1SYP, CHGA
42oligodendroglioma10.1PDGFRA, SYP
43teratocarcinoma10.1SYP, PDGFRA
44neuroblastoma10.1SYP
45tuberous sclerosis10.1STK11, SYP
46pituitary adenoma10.1CHGA, SYP
47merkel cell carcinoma10.0CHGA, SYP, NKX2-1
48papillary carcinoma10.0NKX2-1, SYP, CHGA
49carcinoid syndrome10.0CHGA, SYP, NKX2-1
50systemic lupus erythematosus10.0

Graphical network of the top 20 diseases related to Large Cell Carcinoma:



Diseases related to large cell carcinoma

Symptoms for Large Cell Carcinoma

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Drugs & Therapeutics for Large Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Large Cell Carcinoma

Search NIH Clinical Center for Large Cell Carcinoma

Genetic Tests for Large Cell Carcinoma

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Anatomical Context for Large Cell Carcinoma

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MalaCards organs/tissues related to Large Cell Carcinoma:

31
Lung, Thyroid, Lymph node, Thymus, Brain, Small intestine, Ovary, Prostate

Animal Models for Large Cell Carcinoma or affiliated genes

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Publications for Large Cell Carcinoma

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Articles related to Large Cell Carcinoma:

(show top 50)    (show all 158)
idTitleAuthorsYear
1
A retrospective analysis of the clinicopathological characteristics of large cell carcinoma of the lung. (25452802)
2015
2
USP7 overexpression predicts a poor prognosis in lung squamous cell carcinoma and large cell carcinoma. (25519684)
2015
3
Close Relation of Large Cell Carcinoma to Adenocarcinoma by Hierarchical Cluster Analysis: Implications for Histologic Typing of Lung Cancer on Biopsies. (25789531)
2015
4
Large cell carcinoma of the lung: a tumor in search of an author. A clinically oriented critical reappraisal. (25620799)
2015
5
Large-cell carcinoma of the lung: a diagnostic category redefined by immunohistochemistry and genomics. (24811836)
2014
6
Pulmonary Large Cell Carcinoma Lacking Squamous Differentiation Is Clinicopathologically Indistinguishable From Solid-Subtype Adenocarcinoma. (23738762)
2013
7
Distinct profile of driver mutations and clinical features in immunomarker-defined subsets of pulmonary large-cell carcinoma. (23196793)
2013
8
Mixed squamous and large-cell carcinoma of the lung: a case study and literature review. (23174733)
2012
9
Pulmonary large cell carcinoma mimicking an infected thoracoabdominal aortic aneurysm. (21847044)
2011
10
Cystic tumors of the right atrium caused by nonbacterial thrombotic endocarditis in a patient with large cell carcinoma. (19420823)
2009
11
Large cell carcinoma of the lung and squamous cell carcinoma of the oropharynx presenting as uveitis. (19413230)
2009
12
Humoral hypercalcemia of malignancy in a patient with large cell carcinoma of the lung: report of case and review of literature. (17669716)
2007
13
Identification of HLA-A24 restricted shared antigen recognized by autologous cytotoxic T lymphocytes from a patient with large cell carcinoma of the lung. (17131342)
2007
14
A case of large cell carcinoma of the lung with rhabdoid phenotype]. (16681249)
2006
15
Lymph node metastasis of large-cell carcinoma of the lung in a seventeen-year-old patient: diagnosis by fine-needle aspiration. (17115438)
2006
16
Large cell carcinoma with neuroendocrine morphology of the lung. (16482935)
2006
17
Bilateral adrenal metastases from large cell carcinoma of lung in a female non-smoker patient. (16912999)
2006
18
Large cell neuroendocrine carcinoma of the lung: a comparison with large cell carcinoma with neuroendocrine morphology and small cell carcinoma. (15639721)
2005
19
Solitary adrenal metastasis in large cell carcinoma of lung. (15558361)
2004
20
Cigarette smoking and risk of large cell carcinoma of the lung: a case-control study in Uruguay. (15165084)
2004
21
Immunohistochemical neuroendocrine differentiation is an independent prognostic factor in surgically resected large cell carcinoma of the lung. (12399130)
2002
22
Sarcoid reaction in primary tumor of bronchogenic large cell carcinoma accompanied with massive necrosis. (11300145)
2001
23
Long-term survival of a patient with stage IV pulmonary large cell carcinoma achieved by combined-modality therapy: report of a case. (10883474)
2000
24
Hemopneumothorax and hemoperitoneum in a case with large cell carcinoma of the lung. (10793500)
2000
25
Bronchial arterial infusion with cisplatin followed by irradiation successfully treats recurrent stage IVb thymic large cell carcinoma. (10571098)
1999
26
Large cell carcinoma of the lung: results of resection for a cure. (10047666)
1999
27
Large cell carcinoma of the lung metastatic to nuchal muscle. (9525301)
1997
28
High-dose tamoxifen reverses drug resistance to cisplatin and etoposide in a patient with advanced large cell carcinoma of lung. (9137495)
1997
29
Phase II trial of carboplatin in combination with etoposide in locally advanced large cell carcinoma and adenocarcinoma of the lung. (7655835)
1995
30
Large-cell carcinoma of the lung. With major bleeding and intussusception. (1328355)
1992
31
Large cell carcinoma of the lung secreting human chorionic gonadotropin which responded to combination chemotherapy: case report. (2174998)
1990
32
Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung. (2567993)
1989
33
Large cell carcinoma of the lung: a highly aggressive tumor with dismal prognosis. (2547348)
1989
34
Karyotypic evolution of a human undifferentiated large cell carcinoma of the lung in tissue culture. (2720688)
1989
35
Natural history of adenocarcinoma-large cell carcinoma of the lung: conclusions from screening programs in New York and Baltimore. (2833601)
1988
36
Large cell carcinoma of the lung--ultrastructural and immunohistochemical studies. (2410641)
1985
37
Comparison of combination chemotherapy programs in advanced adenocarcinoma-large cell carcinoma of the lung: a North Central Cancer Treatment Group study. (6322987)
1984
38
Bilateral diffuse malignant melanoma of the uvea associated with large cell carcinoma, giant cell type, of the lung. Case report of a newly described syndrome. (6096784)
1984
39
Ftorafur, adriamycin and mitomycin C (FAM II) for extensive bronchogenic adenocarcinoma and large cell carcinoma. (6323790)
1984
40
Vindesine in the treatment of squamous cell carcinoma (WHO I), adenocarcinoma (WHO III), and large cell carcinoma (WHO IV) of the lung. (6301122)
1982
41
Vindesine in the treatment of squamous cell carcinoma, adenocarcinoma, and large cell carcinoma of the lung. (7055816)
1982
42
Radiotherapy of squamous, adeno- and large cell carcinoma of the lung. (6279292)
1982
43
Ultrastructural features of large cell carcinoma of the lung with reference to the prognosis of patients. (7250954)
1981
44
Human chorionic gonadotropin-secreting large cell carcinoma of the lung detected during follow-up of a patient previously treated for gestational trophoblastic disease. (6249700)
1980
45
Combination chemotherapy with mitomycin C, adriamycin, and cyclophosphamide in advanced adenocarcinoma and large cell carcinoma of the lung. (230896)
1979
46
Mitomycin C in advanced adenocarcinoma and large cell carcinoma of the lung. (203393)
1978
47
Hexamethylmelamine, bleomycin, and CCNU chemotherapy for patients with squamous cell carcinoma, large cell carcinoma, and adenocarcinoma of the lung unresponsive to cyclophosphamide, adriamycin, methotrexate, and procarbazine. (77725)
1978
48
Large-cell carcinoma metastatic to the jaw. Report of a case. (269332)
1977
49
Mechlorethamine (NSC-762) plus CCNU (NSC-79037) in the treatment of inoperable squamous and large cell carcinoma of the lung. (186183)
1976
50
The roentgenographic appearance of large cell carcinoma of the bronchus. (5647726)
1968

Variations for Large Cell Carcinoma

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Expression for genes affiliated with Large Cell Carcinoma

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Search GEO for disease gene expression data for Large Cell Carcinoma.

Pathways for genes affiliated with Large Cell Carcinoma

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Pathways related to Large Cell Carcinoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.7NKX2-1, UCHL1, SYP

Compounds for genes affiliated with Large Cell Carcinoma

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Compounds related to Large Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 31)
idCompoundScoreTop Affiliating Genes
1smcc439.9CHGA, SYP
2111in-pentetreotide439.9CHGA, SYP
3s 100439.9CHGA, SYP
4l-amino acid439.8CHGA, SYP
5mucicarmine439.8NKX2-1, SYP
6streptozotocin439.8CHGA, SYP
7silver439.8CHGA, SYP
8amine439.7SYP, CHGA
9haloperidol43 49 28 2 1213.6CHGA, SYP
10catecholamine439.5SYP, CHGA
115-hydroxytryptamine439.5SYP, CHGA
12b 723439.5CHGA, SYP, NKX2-1
13hematoxylin439.5NKX2-1, SYP, CHGA
14formaldehyde43 2410.4NKX2-1, SYP, CHGA
15forskolin43 49 1211.4CHGA, SYP, NKX2-1
16progesterone43 28 59 24 1213.3NKX2-1, SYP, CHGA
17steroid439.3NKX2-1, SYP, CHGA
18guanine43 24 1211.3SYP, STK11, CHGA
19gold439.2SYP, CHGA
20oligonucleotide439.2CHGA, NKX2-1, PDGFRA
21glycogen43 2410.2SYP, STK11, CHGA
22dexamethasone43 49 28 1212.2NKX2-1, SYP, CHGA
23dopamine43 28 24 1212.0UCHL1, SYP, CHGA
24estrogen438.9CHGA, SYP, NKX2-1, PDGFRA
25retinoic acid43 249.9PDGFRA, NKX2-1, SYP, CHGA
26cyclic amp43 249.8NKX2-1, SYP, STK11, CHGA
27vegf438.7CHGA, STK11, SYP, PDGFRA
28paraffin438.3PDGFRA, NKX2-1, SYP, STK11, CHGA
29calcium43 49 24 1211.3CHGA, STK11, SYP, PDGFRA
30tyrosine438.1PDGFRA, NKX2-1, UCHL1, SYP, CHGA
31serine438.0CHGA, STK11, SYP, UCHL1, NKX2-1

GO Terms for genes affiliated with Large Cell Carcinoma

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Biological processes related to Large Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Leydig cell differentiationGO:00333279.4PDGFRA, NKX2-1
2protein autophosphorylationGO:00467779.3PDGFRA, STK11
3lung developmentGO:00303249.2PDGFRA, NKX2-1

Products for genes affiliated with Large Cell Carcinoma

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Sources for Large Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet