MCID: LRG001
MIFTS: 50

Large Cell Carcinoma

Categories: Rare diseases, Skin diseases, Respiratory diseases, Genetic diseases, Cancer diseases

Aliases & Classifications for Large Cell Carcinoma

MalaCards integrated aliases for Large Cell Carcinoma:

Name: Large Cell Carcinoma 12 14
Carcinoma, Large Cell 41 69
Carcinoma Large Cell 51

Classifications:



External Ids:

Disease Ontology 12 DOID:4552
MeSH 41 D018287
NCIt 46 C3780
SNOMED-CT 64 189551005 22687000
UMLS 69 C0206704

Summaries for Large Cell Carcinoma

Disease Ontology : 12 A carcinoma that is composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm.

MalaCards based summary : Large Cell Carcinoma, also known as carcinoma, large cell, is related to pleomorphic carcinoma and pulmonary large cell neuroendocrine carcinoma. An important gene associated with Large Cell Carcinoma is SYP (Synaptophysin), and among its related pathways/superpathways are Developmental Biology and Neuroscience. The drugs Carboplatin and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include lung, cervix and thyroid, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Large Cell Carcinoma

Diseases in the Small Cell Carcinoma family:

Basal Cell Carcinoma 1 Basal Cell Carcinoma 2
Basal Cell Carcinoma 3 Basal Cell Carcinoma 4
Basal Cell Carcinoma 5 Basal Cell Carcinoma 6
Basal Cell Carcinoma 7 Cell Type Cancer
Cell Type Benign Neoplasm Basal Cell Carcinoma
Large Cell Carcinoma Basal Cell Carcinoma, Multiple

Diseases related to Large Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 pleomorphic carcinoma 31.7 EGFR KRT7 NKX2-1
2 pulmonary large cell neuroendocrine carcinoma 29.0 CHGA ENO2 ROS1 STK11 SYP
3 lung squamous cell carcinoma 28.8 EGFR FGFR1 PTHLH ROS1 TP63
4 squamous cell carcinoma 28.6 EGFR KRT7 PTHLH STK11 TP63
5 large cell neuroendocrine carcinoma 28.0 CHGA EGFR ENO2 KRT7 NCAM1 NKX2-1
6 small cell carcinoma 27.8 CHGA EGFR ENO2 KRT7 NCAM1 NKX2-1
7 adenosquamous carcinoma 27.6 EGFR KRT5 KRT7 PDGFRA PTHLH TP63
8 lung cancer 25.5 CHGA EGFR ENO2 FGFR1 KRT7 NCAM1
9 lung large cell carcinoma 12.4
10 large cell carcinoma with rhabdoid phenotype 12.2
11 thymus large cell carcinoma 12.1
12 lung occult large cell carcinoma 12.0
13 lung mixed small cell and squamous cell carcinoma 11.0
14 ureter small cell carcinoma 10.6 CHGA SYP
15 lung acinar adenocarcinoma 10.5 KRT7 NKX2-1
16 adenoma of the pancreas 10.5 CHGA SYP
17 acinar cell cystadenocarcinoma 10.5 CHGA SYP
18 peritoneal serous adenocarcinoma 10.5 CHGA SYP
19 cellular ependymoma 10.5 CHGA SYP
20 primary hypereosinophilic syndrome 10.5 FGFR1 PDGFRA
21 primary hepatic neuroendocrine carcinoma 10.5 CHGA SYP
22 ovarian germ cell teratoma 10.5 KRT7 NKX2-1
23 gastrointestinal neuroendocrine tumor 10.5 CHGA SYP
24 ovarian germ cell cancer 10.5 KRT7 NKX2-1
25 mucinous adenofibroma 10.5 KRT7 SYP
26 cystic basal cell carcinoma 10.5 KRT7 TP63
27 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.5 FGFR1 PDGFRA
28 hemangioma of lung 10.5 NKX2-1 TP63
29 chordoid meningioma 10.5 CHGA SYP
30 transverse colon cancer 10.5 DSC3 KRT7
31 intracranial primitive neuroectodermal tumor 10.4 CHGA ENO2
32 mucinous bronchioloalveolar adenocarcinoma 10.4 KRT7 NKX2-1
33 malignant sertoli cell tumor 10.4 ENO2 SYP
34 sinonasal undifferentiated carcinoma 10.4 ENO2 SYP
35 cribriform carcinoma 10.4 KRT7 TP63
36 pancreatic somatostatinoma 10.4 ENO2 SYP
37 papillary tumor of the pineal region 10.4 ENO2 SYP
38 epithelioid malignant peripheral nerve sheath tumor 10.4 CHGA ENO2
39 lung combined type small cell carcinoma 10.4 NCAM1 SYP
40 ovarian carcinosarcoma 10.4 ENO2 SYP
41 goblet cell carcinoid 10.4 CHGA ENO2
42 sclerosing hepatic carcinoma 10.4 CHGA PTHLH
43 central nervous system primitive neuroectodermal neoplasm 10.3 ENO2 SYP
44 renal adenoma 10.3 KRT7 NCAM1
45 gastric tubular adenocarcinoma 10.3 CHGA KRT7 SYP
46 pancreatic endocrine carcinoma 10.3 NCAM1 SYP
47 inverted transitional papilloma 10.3 KRT5 KRT7
48 cerebellum cancer 10.3 ENO2 SYP
49 balloon cell malignant melanoma 10.3 KRT5 KRT7
50 cystadenoma 10.3 CHGA KRT7 SYP

Graphical network of the top 20 diseases related to Large Cell Carcinoma:



Diseases related to Large Cell Carcinoma

Symptoms & Phenotypes for Large Cell Carcinoma

GenomeRNAi Phenotypes related to Large Cell Carcinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.83 EGFR
2 Decreased viability GR00173-A 9.83 PDGFRA
3 Decreased viability GR00221-A-1 9.83 EGFR FGFR1 PDGFRA ROS1 STK33
4 Decreased viability GR00221-A-2 9.83 FGFR1 ROS1 STK33
5 Decreased viability GR00221-A-3 9.83 PDGFRA
6 Decreased viability GR00221-A-4 9.83 EGFR PDGFRA STK33
7 Decreased viability GR00342-S-1 9.83 ROS1
8 Decreased Hepatitis C Virus pseudoparticles (HCVpp GR00234-A-1 9.33 EGFR STK11 STK33
9 Increased colony dispersion (increased number of colonies and decreased number of cells per colony) GR00212-A 8.8 FGFR1 PDGFRA ROS1

MGI Mouse Phenotypes related to Large Cell Carcinoma:

43 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.26 ROS1 PDGFRA STK11 PTHLH TP63 ENO2
2 behavior/neurological MP:0005386 10.24 PDGFRA STK11 SYP PTHLH NKX2-1 TP63
3 growth/size/body region MP:0005378 10.16 NKX2-1 STK11 PDGFRA PTHLH TP63 ENO2
4 craniofacial MP:0005382 10.11 PDGFRA STK11 PTHLH TP63 FGFR1 EGFR
5 mortality/aging MP:0010768 10.11 NKX2-1 STK11 PDGFRA PTHLH TP63 NCAM1
6 digestive/alimentary MP:0005381 10.1 PDGFRA STK11 PTHLH TP63 NKX2-1 FGFR1
7 endocrine/exocrine gland MP:0005379 10.08 PDGFRA STK11 PTHLH NKX2-1 TP63 CHGA
8 integument MP:0010771 10.03 PDGFRA STK11 PTHLH TP63 FGFR1 DSC3
9 no phenotypic analysis MP:0003012 9.97 ROS1 PDGFRA STK11 TP63 NKX2-1 FGFR1
10 limbs/digits/tail MP:0005371 9.88 PDGFRA PTHLH TP63 FGFR1 KRT5 EGFR
11 normal MP:0002873 9.86 PDGFRA STK11 SYP NKX2-1 TP63 FGFR1
12 renal/urinary system MP:0005367 9.76 PDGFRA STK11 PTHLH TP63 FGFR1 CHGA
13 reproductive system MP:0005389 9.61 ROS1 PDGFRA STK11 PTHLH NKX2-1 TP63
14 respiratory system MP:0005388 9.17 PDGFRA STK11 PTHLH NKX2-1 TP63 ENO2

Drugs & Therapeutics for Large Cell Carcinoma

Drugs for Large Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 4,Phase 3 41575-94-4 10339178 38904 498142
2
Paclitaxel Approved, Vet_approved Phase 4,Phase 3 33069-62-4 36314
3
Everolimus Approved Phase 4 159351-69-6 6442177
4
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
5
Sirolimus Approved, Investigational Phase 4 53123-88-9 46835353 6436030 5284616
6 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1
7 Albumin-Bound Paclitaxel Phase 4,Phase 3
8 Antineoplastic Agents, Phytogenic Phase 4,Phase 3
9 Anti-Bacterial Agents Phase 4
10 Antibiotics, Antitubercular Phase 4
11 Antifungal Agents Phase 4
12 Anti-Infective Agents Phase 4
13 Immunosuppressive Agents Phase 4
14
Crizotinib Approved Phase 3,Phase 1 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
15 Mitogens Phase 3,Phase 1
16 Antibodies Phase 3,Phase 2
17 Antibodies, Monoclonal Phase 3,Phase 2
18 Immunoglobulins Phase 3,Phase 2
19 Protein Kinase Inhibitors Phase 3,Phase 1
20 insulin Phase 3
21 Insulin, Globin Zinc Phase 3
22
Erlotinib Hydrochloride Phase 3 183319-69-9 176871
23 tyrosine Nutraceutical Phase 3,Phase 1
24
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 43805 6857599 5310940 9887054
25
nivolumab Approved Phase 2 946414-94-4
26
Somatostatin Approved, Investigational Phase 1, Phase 2 38916-34-6, 51110-01-1 53481605
27
Pemetrexed Approved, Investigational Phase 2 150399-23-8, 137281-23-3 60843 446556
28
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
29
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
30
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
31
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
32
Docetaxel Approved May 1996, Investigational Phase 2,Phase 1 114977-28-5 148124 9877265
33
motexafin gadolinium Investigational Phase 2,Phase 1 156436-89-4 12047567
34 Pharmaceutical Solutions Phase 2,Phase 1
35 Vaccines Phase 1, Phase 2
36 Dermatologic Agents Phase 2,Phase 1
37 Photosensitizing Agents Phase 2,Phase 1
38 Hormone Antagonists Phase 1, Phase 2
39 Hormones Phase 1, Phase 2
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
41 Folic Acid Antagonists Phase 2
42 Nucleic Acid Synthesis Inhibitors Phase 2
43 Vitamin B Complex Phase 2
44 Alkylating Agents Phase 2
45 Folate Nutraceutical Phase 2
46 Vitamin B9 Nutraceutical Phase 2
47
Cisplatin Approved Phase 1 15663-27-1 2767 441203 84093

Interventional clinical trials:

(show all 22)

# Name Status NCT ID Phase Drugs
1 Safety and Efficacy Study of Abraxane in Combination With Carboplatin to Treat Advanced NSCL Cancer in the Elderly Completed NCT02151149 Phase 4 nab-paclitaxel;Carboplatin
2 RAD001 With Paclitaxel and Carboplatin in First Line Treatment of Patients With Advanced Large Cell Lung Cancer With Neuroendocrine Differentiation Completed NCT01317615 Phase 4 RAD001;Paclitaxel;Carboplatin
3 ZD6474 (ZACTIMAâ„¢) Phase III Study in EGFR Failures Completed NCT00404924 Phase 3 ZD6474 (vandetanib)
4 ALTA-1L Study: A Phase 3 Study of Brigatinib Versus Crizotinib in ALK-positive Advanced Non-Small Cell Lung Cancer Patients Active, not recruiting NCT02737501 Phase 3 Brigatinib;Xalkori (crizotinib)
5 Carboplatin And Paclitaxel With Or Without CP-751, 871 (An IGF-1R Inhibitor) For Advanced NSCLC Of Squamous, Large Cell And Adenosquamous Carcinoma Histology Terminated NCT00596830 Phase 3 CP-751,871 (Figitumumab);Carboplatin;Paclitaxel;Carboplatin;Paclitaxel
6 Trial Of CP-751, 871 And Erlotinib In Refractory Lung Cancer Terminated NCT00673049 Phase 3 CP 751,871 (Figitumumab);Erlotinib;Erlotinib
7 A Phase II Clinical Trial of Docetaxel, Oxaliplatin Combination Chemotherapy in Patients With Stage IIIB/IV Non-adenocarcinoma, Non-small Cell Lung Cancer (NSCLC) as Second-line Treatment Unknown status NCT01497041 Phase 2 Docetaxel;Oxaliplatin
8 A Double-blind Study Evaluating IPI-504 and Docetaxel in Patients With Non-Small Cell Lung Cancer Completed NCT01362400 Phase 2 IPI 504 plus Docetaxel;Placebo plus Docetaxel
9 Vaccine Treatment for Advanced Non-Small Cell Lung Cancer Completed NCT00073398 Phase 1, Phase 2
10 Clinical Trials Comparing Immunotherapy Plus Stereotactic Ablative Radiotherapy (I-SABR) Versus SABR Alone for Stage I, Selected Stage IIa or Isolated Lung Parenchymal Recurrent Non-Small Cell Lung Cancer: I-SABR Recruiting NCT03110978 Phase 2 Nivolumab
11 PEN-221 in Somatostatin Receptor 2 Expressing Advanced Cancers Including Neuroendocrine and Small Cell Lung Cancers Recruiting NCT02936323 Phase 1, Phase 2 PEN-221
12 Stereotactic Body Radiotherapy (SBRT) Versus Stereotactic Body Proton Therapy (SBPT) Terminated NCT01511081 Phase 2
13 Trial of Motexafin Gadolinium and Pemetrexed (Alimta®) for Second Line Treatment in Patients With Non-Small Cell Lung Cancer Terminated NCT00365183 Phase 2 Motexafin gadolinium and pemetrexed
14 Study of Maintenance Temozolomide Versus Observation in Stable or Responding Stage III/IV Non-Small Cell Lung Cancer Patients (Study P05146) Terminated NCT00632203 Phase 2 Temozolomide
15 A Study of Motexafin Gadolinium (MGd) in Combination With Docetaxel and Cisplatin for Treatment of Non-Small Cell Lung Cancer (NSCLC) Completed NCT00102505 Phase 1 Motexafin Gadolinium Injection
16 An Open Label Study of a Peptide Vaccine in Patients With Stage IIb or IIIa Non-Small Cell Lung Cancer Completed NCT00054899 Phase 1
17 -02341066 and PF-00299804 for Advanced Non-Small Cell Lung Cancer Terminated NCT01441128 Phase 1 PF-02341066/PF-00299804;PF-02341066/PF-00299804
18 Photodynamic Therapy (PDT) With Temoporfin for Non-Resectable Non-Small-Cell Lung Cancer Withdrawn NCT01637376 Phase 1 Temoporfin
19 Use of Social Networking to Survey Women With Small and Large Cell Carcinomas of the Cervix Recruiting NCT01606293
20 Mass Spectral Fingerprinting in Lung Cancer Recruiting NCT02781857
21 Lung Cancer STARS Trial - STARS Revised Clinical Trial Protocol: Stereotactic Ablative Radiotherapy (SABR) in Stage I Non-small Cell Lung Cancer Patients Who Can Undergo Lobectomy Active, not recruiting NCT02357992
22 An Expanded Access Study of Brigatinib for Patients With ALK-positive Advanced Non-Small Cell Lung Cancer No longer available NCT02784158 Brigatinib

Search NIH Clinical Center for Large Cell Carcinoma

Cochrane evidence based reviews: carcinoma, large cell

Genetic Tests for Large Cell Carcinoma

Anatomical Context for Large Cell Carcinoma

MalaCards organs/tissues related to Large Cell Carcinoma:

38
Lung, Cervix, Thyroid, Ovary, Prostate, Lymph Node, Brain

Publications for Large Cell Carcinoma

Articles related to Large Cell Carcinoma:

(show top 50) (show all 170)
# Title Authors Year
1
Serotype-Specific Killing of Large Cell Carcinoma Cells by Reovirus. ( 28587298 )
2017
2
Clinicopathological and genetic characteristics of pulmonary large cell carcinoma under 2015 WHO classification: a pilot study. ( 29246019 )
2017
3
Expression of the CXCR4 ligand SDF-1/CXCL12 is prognostically important for adenocarcinoma and large cell carcinoma of the lung. ( 26818832 )
2016
4
Heterotypic paracrine signaling drives fibroblast senescence and tumor progression of large cell carcinoma of the lung. ( 27384989 )
2016
5
BRAF mutations in sarcomatoid and large cell carcinoma of the lung-reply. ( 27939780 )
2016
6
BRAF mutations in sarcomatoid and large cell carcinoma of the lung. ( 27939777 )
2016
7
The development of large-cell carcinoma in the wall of a giant bulla complicated by hemorrhage. ( 26964998 )
2016
8
Prolonged survival with erlotinib followed by afatinib in a caucasian smoker with metastatic, poorly differentiated large cell carcinoma of the lung: a case report. ( 26186355 )
2015
9
Global analysis of chromosome 1 genes among patients with lung adenocarcinoma, squamous carcinoma, large-cell carcinoma, small-cell carcinoma, or non-cancer. ( 25937073 )
2015
10
A retrospective analysis of the clinicopathological characteristics of large cell carcinoma of the lung. ( 25452802 )
2015
11
USP7 overexpression predicts a poor prognosis in lung squamous cell carcinoma and large cell carcinoma. ( 25519684 )
2015
12
Frequent loss of the expression of multiple subunits of the SWI/SNF complex in large cell carcinoma and pleomorphic carcinoma of the lung. ( 26345631 )
2015
13
Close Relation of Large Cell Carcinoma to Adenocarcinoma by Hierarchical Cluster Analysis: Implications for Histologic Typing of Lung Cancer on Biopsies. ( 25789531 )
2015
14
Large cell carcinoma of the lung: a tumor in search of an author. A clinically oriented critical reappraisal. ( 25620799 )
2015
15
Oxidative stress associates with aggressiveness in lung large-cell carcinoma. ( 25638031 )
2015
16
The BCL11A-XL expression predicts relapse in squamous cell carcinoma and large cell carcinoma. ( 26543611 )
2015
17
Dissecting Pulmonary Large-Cell Carcinoma by Targeted Next Generation Sequencing of Several Cancer Genes Pushes Genotypic-Phenotypic Correlations to Emerge. ( 26317919 )
2015
18
Large cell carcinoma on the bullous wall detected in a specimen from a patient with spontaneous pneumothorax: report of a case. ( 25364539 )
2014
19
Distinct profile of driver mutations and clinical features in immunomarker-defined subsets of pulmonary large-cell carcinoma. ( 24384807 )
2014
20
Treatment outcomes of patients with different subtypes of large cell carcinoma of the lung. ( 25085555 )
2014
21
Large-cell carcinoma of the lung: a diagnostic category redefined by immunohistochemistry and genomics. ( 24811836 )
2014
22
Large cell carcinoma of lung: On the verge of extinction? ( 25023633 )
2014
23
Large cell carcinoma of the lung: clinically oriented classification integrating immunohistochemistry and molecular biology. ( 24221342 )
2014
24
Urinary bladder urothelial carcinoma with expression of KIT and PDGFRA and showing diverse differentiations into plasmacytoid, clear cell, acantholytic, nested, and spindle variants, and into adenocarcinoma, signet-ring cell carcinoma, small cell carcinoma, large cell carcinoma, and pleomorphic carcinoma. ( 23696935 )
2013
25
Pulmonary Large Cell Carcinoma Lacking Squamous Differentiation Is Clinicopathologically Indistinguishable From Solid-Subtype Adenocarcinoma. ( 23738762 )
2013
26
Distinct profile of driver mutations and clinical features in immunomarker-defined subsets of pulmonary large-cell carcinoma. ( 23196793 )
2013
27
Hypereosinophilia driven by GM-CSF in large-cell carcinoma of the lung. ( 22420949 )
2012
28
Mixed squamous and large-cell carcinoma of the lung: a case study and literature review. ( 23174733 )
2012
29
Rhabdoid large cell carcinoma of lung, with illustrative immunohistochemical and molecular findings. ( 22505007 )
2012
30
Acute small bowel obstruction: a rare initial presentation for the metastasis of the large-cell carcinoma of the lung. ( 22284720 )
2012
31
Heterogeneity of large cell carcinoma of the lung: an immunophenotypic and miRNA-based analysis. ( 22031317 )
2011
32
Large cell carcinoma of the lacrimal gland diagnosed by fine needle aspiration biopsy. ( 22132846 )
2011
33
Pulmonary large cell carcinoma mimicking an infected thoracoabdominal aortic aneurysm. ( 21847044 )
2011
34
Primary undifferentiated large cell carcinoma of the lacrimal gland. ( 21276618 )
2011
35
Intussusception of small intestine due to metastasis of large cell carcinoma of the lung with a rhabdoid phenotype. ( 20956201 )
2010
36
Toona sinensis extracts induced cell cycle arrest and apoptosis in the human lung large cell carcinoma. ( 20123594 )
2010
37
Results of surgical resection for patients with large cell carcinoma of the lung. ( 20547250 )
2010
38
Curcumin inhibits human lung large cell carcinoma cancer tumour growth in a murine xenograft model. ( 20077433 )
2010
39
Differential Thymidylate Synthase Expression in Different Variants of Large-Cell Carcinoma of the Lung. ( 19996214 )
2009
40
Desmocollin-3: a new marker of squamous differentiation in undifferentiated large-cell carcinoma of the lung. ( 19287461 )
2009
41
Cystic tumors of the right atrium caused by nonbacterial thrombotic endocarditis in a patient with large cell carcinoma. ( 19420823 )
2009
42
Large cell carcinoma of the lung: an endangered species? ( 19444077 )
2009
43
Large cell carcinoma of the lung and squamous cell carcinoma of the oropharynx presenting as uveitis. ( 19413230 )
2009
44
Immunohistochemical characterization of a pulmonary large-cell carcinoma in a dog. ( 18587094 )
2008
45
Selective expression of S100A7 in lung squamous cell carcinomas and large cell carcinomas but not in adenocarcinomas and small cell carcinomas. ( 18364444 )
2008
46
p53 immunostaining is correlated with reduced survival and is not correlated with gene mutations in resected pulmonary large cell carcinomas. ( 17665040 )
2007
47
Identification of HLA-A24 restricted shared antigen recognized by autologous cytotoxic T lymphocytes from a patient with large cell carcinoma of the lung. ( 17131342 )
2007
48
Abnormalities of epidermal growth factor receptor in lung squamous-cell carcinomas, adenosquamous carcinomas, and large-cell carcinomas: tyrosine kinase domain mutations are not rare in tumors with an adenocarcinoma component. ( 17238183 )
2007
49
Humoral hypercalcemia of malignancy in a patient with large cell carcinoma of the lung: report of case and review of literature. ( 17669716 )
2007
50
Hypoglycemia due to paraneoplastic secretion of insulin-like growth factor-I in a patient with metastasizing large-cell carcinoma of the lung. ( 17299065 )
2007

Variations for Large Cell Carcinoma

Expression for Large Cell Carcinoma

Search GEO for disease gene expression data for Large Cell Carcinoma.

Pathways for Large Cell Carcinoma

GO Terms for Large Cell Carcinoma

Biological processes related to Large Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.73 EGFR FGFR1 NCAM1 PDGFRA
2 phosphorylation GO:0016310 9.73 EGFR FGFR1 PDGFRA ROS1 STK11 STK33
3 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.7 EGFR PDGFRA ROS1
4 cornification GO:0070268 9.69 DSC3 KRT5 KRT7
5 phosphatidylinositol phosphorylation GO:0046854 9.67 EGFR FGFR1 PDGFRA
6 lung development GO:0030324 9.65 EGFR FGFR1 NKX2-1
7 protein phosphorylation GO:0006468 9.63 EGFR FGFR1 PDGFRA ROS1 STK11 STK33
8 peptidyl-tyrosine phosphorylation GO:0018108 9.62 EGFR FGFR1 PDGFRA ROS1
9 anatomical structure formation involved in morphogenesis GO:0048646 9.54 NKX2-1 TP63
10 cerebral cortex cell migration GO:0021795 9.46 EGFR NKX2-1
11 salivary gland morphogenesis GO:0007435 9.4 EGFR FGFR1
12 positive regulation of phospholipase C activity GO:0010863 9.37 FGFR1 PDGFRA
13 epidermis development GO:0008544 9.26 EGFR KRT5 PTHLH TP63
14 protein autophosphorylation GO:0046777 9.02 EGFR FGFR1 PDGFRA STK11 STK33

Molecular functions related to Large Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.8 EGFR FGFR1 PDGFRA ROS1 STK11 STK33
2 protein tyrosine kinase activity GO:0004713 9.56 EGFR FGFR1 PDGFRA ROS1
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.54 EGFR FGFR1 PDGFRA
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.46 EGFR FGFR1 NCAM1 PDGFRA
5 protein kinase activity GO:0004672 9.43 EGFR FGFR1 PDGFRA ROS1 STK11 STK33
6 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.92 EGFR FGFR1 PDGFRA ROS1

Sources for Large Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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