MCID: LRG008
MIFTS: 40

Large Granular Lymphocyte Leukemia malady

Immune diseases category

Summaries for Large Granular Lymphocyte Leukemia

About this section
Sources:
42NIH Rare Diseases, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Large granular lymphocyte (lgl) leukemia is a rare cancer of a type of white blood cells called lymphocytes. lgl leukemia causes a slow increase in white blood cells called t lymphocytes, or t cells, which originate in the lymph system and bone marrow and help to fight infection. this disease usually affects people in their sixties. symptoms include anemia; low levels of platelets (thrombocytopenia) and infection-fighting neutrophils (neutropenia) in the blood; and an enlarged spleen. about one-third of patients are asymptomatic at the time of diagnosis. the exact cause of lgl leukemia is unknown. doctors can diagnose this disease through a bone marrow biopsy, or by using a specialized technique in which various types of blood or bone marrow cells are separated, identified, and counted. last updated: 8/2/2011

MalaCards: Large Granular Lymphocyte Leukemia, also known as t-cell large granular lymphocyte leukemia, is related to leukemia and arthritis. An important gene associated with Large Granular Lymphocyte Leukemia is KIR2DL1 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1), and among its related pathways are Malaria and Legionellosis. The compounds pentoxifylline and pge2 have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and bone, and related mouse phenotypes are skeleton and hematopoietic system.

Aliases & Classifications for Large Granular Lymphocyte Leukemia

About this section
Sources:
42NIH Rare Diseases, 60UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

large granular lymphocyte leukemia 42
t-cell large granular lymphocyte leukemia 42 60
leukemia, large granular lymphocytic 60
lgl leukemia 42


Related Diseases for Large Granular Lymphocyte Leukemia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Large Granular Lymphocyte Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.1IL2RA, SPHK1, IL6, IL15, CD52, LBR
2arthritis31.0TNF, IL8, IL6
3rheumatoid arthritis31.0SPHK1, CD52, IL2RA, IL15, LBR, IL10
4hepatitis30.6IL18
5myeloma30.6IL15, IL6
6lupus erythematosus30.3IL18
7sjogren's syndrome30.3IL2RA
8crohn's disease30.3TNF
9celiac disease30.3IL15
10ulcerative colitis30.3TNF
11thrombocytopenia30.3IL6
12hepatitis b30.3IL18, IL10, IL2RA
13graft versus host disease30.3IL18, TNF, IL2RA, IL10, IL15
14hepatocellular carcinoma30.3IL6, IL15
15systemic lupus erythematosus30.3IL18, IL2RA, IL6, IL10, IL15, LBR
16multiple sclerosis30.3TNF, LBR, CD52, IL2RA, IL15, IL18
17hepatitis c30.3TNF, IL18, IL10
18vasculitis30.1TNF
19behcet's disease30.1IL2RA, TNF, KIR2DL1, LBR, IL18, IL8
20t-cell large granular lymphocyte leukemia11.2
21t-cell leukemia11.2
22pure red-cell aplasia10.8
23chronic lymphocytic leukemia10.7
24natural killer cell leukemia10.7
25neutropenia10.7
26acute leukemia10.6
27acute lymphocytic leukemia10.6
28hemolytic anemia10.5
29autoimmune hemolytic anemia10.4
30hairy cell leukemia10.4
31prolymphocytic leukemia10.4
32purpura10.4
33autoimmune thrombocytopenic purpura10.2
34lambert-eaton myasthenic syndrome10.2
35acquired thrombocytopenia10.2
36acute t cell leukemia10.2
37common variable immunodeficiency10.2
38felty's syndrome10.2
39gamma heavy chain disease10.2
40protein-losing enteropathy10.2
41autoimmune hepatitis10.2
42malignant histiocytosis10.2
43granuloma annulare10.2
44aplastic anemia10.2
45candidiasis10.2
46encephalitis10.2
47heavy chain disease10.2
48histiocytosis10.2
49myelofibrosis10.2
50neuropathy10.2

Graphical network of the top 20 diseases related to Large Granular Lymphocyte Leukemia:



Diseases related to large granular lymphocyte leukemia

Clinical Features for Large Granular Lymphocyte Leukemia

About this section

Drugs & Therapeutics for Large Granular Lymphocyte Leukemia

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Large Granular Lymphocyte Leukemia

Drug clinical trials:

Search ClinicalTrials for Large Granular Lymphocyte Leukemia

Search NIH Clinical Center for Large Granular Lymphocyte Leukemia

Search CenterWatch for Large Granular Lymphocyte Leukemia

Genetic Tests for Large Granular Lymphocyte Leukemia

About this section

Anatomical Context for Large Granular Lymphocyte Leukemia

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Large Granular Lymphocyte Leukemia:

32
T cells, Bone marrow, Bone, Spleen

Animal Models for Large Granular Lymphocyte Leukemia or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Large Granular Lymphocyte Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.9IL6, TYROBP, HCST, DUSP2
2MP:00053978.9IL2RA, TYROBP, HCST, LBR, TNF, IL15
3MP:00053848.8TNF, LBR, HCST, TYROBP, IL2RA, IL15
4MP:00053878.7SPHK1, KLRD1, TNF, LBR, DUSP2, HCST

Publications for Large Granular Lymphocyte Leukemia

About this section

Genetic Variations for Large Granular Lymphocyte Leukemia

About this section

Expression for genes affiliated with Large Granular Lymphocyte Leukemia

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Large Granular Lymphocyte Leukemia

Search GEO for disease gene expression data for Large Granular Lymphocyte Leukemia.

Pathways for genes affiliated with Large Granular Lymphocyte Leukemia

About this section
Sources:
29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 52R&D Systems, 53Reactome
See all sources

Pathways related to Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IL18
210.4IL8
3
Hide members
10.3IL15RA
4
Hide members
10.2IL15RA, IL2RA
510.2IL18, IL15
610.1IL6, IL8, IL18
710.1IL2RA, IL8, IL6
8
Hide members
10.1IL8, IL2RA, TNF
910.1TNF, IL2RA, IL6
10
Immune response Bacterial infections in normal airways
10.1TNF, IL8, IL6
1110.1TNF, IL8, IL6
1210.1IL6, IL10, TNF
13
Hide members
10.1IL18, IL15RA, IL15
14
Hide members
10.1IL2RA, IL15, IL15RA
15
Hide members
10.1IL2RA, IL15, IL15RA
16
Hide members
10.0IL6, IL8, IL18, TNF
17
Hide members
10.0IL6, IL8, IL18, TNF
18
Development PDGF signaling via STATs and NF-kB
Hide members
10.0IL6, IL18, IL10, TNF
1910.0IL6, IL18, IL10, TNF
20
Hide members
10.0TNF, IL10, IL18, IL6
21
Hide members
10.0TNF, IL10, IL18, IL6
2210.0IL6, IL8, IL10, TNF
23
Hide members
10.0IL6, IL8, IL10, TNF
2410.0TNF, IL10, IL8, IL6
2510.0TNF, IL10, IL8, IL6
26
Hide members
10.0HCST, TYROBP, KIR2DL3, KIR2DL1
279.9IL2RA, IL15, IL15RA, IL10, IL6
28
Hide members
9.9TNF, IL2RA, IL15, IL15RA, IL10
29
Hide members
9.9IL6, IL15RA, IL15, IL2RA, TNF
309.9TNF, IL2RA, IL15, IL15RA, IL6
319.9TNF, IL10, IL18, IL6, SPHK1
32
Hide members
9.8TNF, IL2RA, IL15, IL18, IL8, IL6
339.8IL6, TNF, IL15, IL10, IL18, IL8
34
Hide members
9.8IL6, IL18, IL2RA, TYROBP, HCST, KLRD1
35
Hide members
9.6KLRD1, TNF, HCST, TYROBP, KIR2DL3, KIR2DL1
36
Hide members
9.5IL15RA, IL15, IL2RA, TNF, IL10, IL18
37
Hide members
9.5KLRD1, TNF, IL2RA, IL15, IL15RA, IL10

Compounds for genes affiliated with Large Granular Lymphocyte Leukemia

About this section
Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 49PharmGKB, 24HMDB
See all sources

Compounds related to Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1pentoxifylline44 1111.7LBR, IL18
2pge24410.7SPHK1
3gm-csf44 2811.7IL10, TNF
4prednisolone44 28 1112.6IL2RA
5hydrocortisone44 2 59 1113.6IL8
6cyclosporin a44 28 5912.5LBR, IL15, IL2RA
7cycloheximide4410.5IL18
8dexamethasone44 49 28 1113.4IL6, IL15, LBR
9cdp5714410.4IL6, IL10, TNF
102,5-oligoadenylate4410.4IL2RA, TNF
11natalizumab44 1111.4IL10, IL2RA, IL18, TNF
12mip 1alpha4410.4IL6, TNF, IL10, IL8
135 aminosalicylic acid4410.4TNF, IL8, IL10, IL2RA
14toxin-14410.4KLRD1, TNF, IL10, IL8
15con a4410.4LBR, IL2RA, IL10, IL18
16polymyxin b4410.4TNF, IL10, IL6, IL8
17tuberculin4410.3IL18, IL2RA, LBR, IL15, IL10
18rantes4410.3TNF, LBR, IL15, IL6, IL2RA
19imiquimod44 28 59 1113.3IL6, IL18, IL10, TNF, IL8
20groalpha4410.3IL10, IL18, IL8, IL6, TNF
21lipoteichoic acid4410.3IL10, IL18, IL8, IL6, TNF
22poly(i-c)4410.3IL6, IL8, IL18, TNF, IL15
23thalidomide44 49 59 1113.3IL2RA, IL10, IL18, IL6, TNF
248-isoprostane4410.3IL10, IL8, TNF, IL6
25peptidoglycan44 2811.3TNF, IL15, IL6, IL8, IL10
26chloroquine44 2 49 28 1114.2IL18, TNF, IL2RA, IL15, IL10
27il-124410.2IL6, IL8, IL18, IL10, IL15, TNF
28okt34410.2IL2RA, LBR, TNF, IL15, IL10, IL6
29polyinosinic-polycytidylic acid4410.2IL18, TNF, IL15, IL8, IL10, IL6
30etanercept44 49 1112.2IL10, IL18, IL15, IL6, TNF, IL8
31atorvastatin44 49 28 11 2414.2IL10, IL6, IL18, IL2RA, TNF
32ccl344 2811.2IL10, IL18, IL8, TNF, IL15, IL6
33gluten4410.2IL18, IL2RA
34ionomycin4410.2IL15, TNF, IL2RA, IL18, LBR, IL10
35neopterin4410.2IL6, TNF, LBR, IL2RA, IL10, IL18
36rituximab44 49 1112.1IL2RA, IL15, TNF, IL10, IL6, CD52
37infliximab44 49 1112.1IL15, IL2RA, IL10, LBR, IL18, TNF
38methotrexate44 49 1112.1TNF, IL18, IL6, IL10, IL15, IL2RA
39il 104410.1IL6, IL8, TNF, IL2RA, IL15, IL18
40tarc4410.0TNF, IL8, IL18, IL10
41n acetylcysteine4410.0IL2RA, IL18, IL8, IL6, SPHK1, TNF
42tgf beta14410.0IL18, IL10, TNF, IL15, IL6
43histamine44 28 2412.0IL18, IL15, IL2RA, TNF, IL8, IL10
44thymidine44 2411.0TNF, IL2RA, IL15, LBR, IL6, IL18
45simvastatin44 49 59 28 11 2414.9IL18, IL6, IL8, IL10, TNF
46rapamycin449.8SPHK1, IL18, IL10, IL15, IL2RA, LBR
47vegf449.8SPHK1, IL6, IL8, IL10, IL18, IL2RA
48nitric oxide44 11 2411.7IL10, IL18, IL15, LBR, FAM215A, IL8
49ly294002449.4IL6, IL8, IL18, IL10, TNF, SPHK1
50tyrosine449.4IL15, KLRD1, IL2RA, IL6, SPHK1, KIR2DL1

GO Terms for genes affiliated with Large Granular Lymphocyte Leukemia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.0IL6, IL2RA, TNF, KLRD1
2extracellular spaceGO:0056159.5IL6, TNF, IL15, IL15RA, IL10, IL18
3integral to plasma membraneGO:0058879.3TNF, TYROBP, CD52, IL15, SIGLEC7, KIR2DL3

Biological processes related to Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cytokine secretion involved in immune responseGO:00274010.6IL10
2receptor biosynthetic processGO:03280010.5IL10, TNF
3type 2 immune responseGO:04209210.5IL18, IL10
4positive regulation of tissue remodelingGO:03410510.4IL15, IL18
5positive regulation of chemokine productionGO:03272210.4IL6, IL18, TNF
6positive regulation of natural killer cell proliferationGO:03281910.4IL15, IL18
7negative regulation of lipid storageGO:01088810.4IL6, TNF
8positive regulation of NF-kappaB import into nucleusGO:04234610.4TNF, IL18, SPHK1
9epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.4IL6, TNF
10calcium-mediated signalingGO:01972210.3TNF, IL8, SPHK1
11response to molecule of bacterial originGO:00223710.3IL8, IL10
12positive regulation of interleukin-17 productionGO:03274010.2IL18, IL15
13regulation of immune responseGO:05077610.2KLRD1, HCST, TYROBP, KIR2DL3, KIR2DL1
14response to glucocorticoid stimulusGO:05138410.2TNF, IL10, IL6
15immune responseGO:00695510.1IL2RA, IL15, IL18, IL8, KIR2DL3, KIR2DL1
16positive regulation of natural killer cell differentiationGO:03282510.1IL15RA, IL15
17inflammatory responseGO:0069549.9SPHK1, IL6, IL8, IL18, IL10, IL15
18positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.8TNF, IL10, IL6

Molecular functions related to Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.9IL6, IL18, IL10, IL15, TNF

Products for genes affiliated with Large Granular Lymphocyte Leukemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Large Granular Lymphocyte Leukemia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet