MCID: LRG008
MIFTS: 39

Large Granular Lymphocyte Leukemia malady

Categories: Rare diseases, Immune diseases, Cancer diseases

Aliases & Classifications for Large Granular Lymphocyte Leukemia

Aliases & Descriptions for Large Granular Lymphocyte Leukemia:

Name: Large Granular Lymphocyte Leukemia 50
T-Cell Large Granular Lymphocyte Leukemia 50 69
Leukemia, Large Granular Lymphocytic 69
Lgl Leukemia 50

Classifications:



Summaries for Large Granular Lymphocyte Leukemia

NIH Rare Diseases : 50 large granular lymphocyte (lgl) leukemia is a rare cancer of a type of white blood cells called lymphocytes. lgl leukemia causes a slow increase in white blood cells called t lymphocytes, or t cells, which originate in the lymph system and bone marrow and help to fight infection. this disease usually affects people in their sixties. symptoms include anemia; low levels of platelets (thrombocytopenia) and infection-fighting neutrophils (neutropenia) in the blood; and an enlarged spleen. about one-third of patients are asymptomatic at the time of diagnosis. the exact cause of lgl leukemia is unknown. doctors can diagnose this disease through a bone marrow biopsy, or by using a specialized technique in which various types of blood or bone marrow cells are separated, identified, and counted. last updated: 8/2/2011

MalaCards based summary : Large Granular Lymphocyte Leukemia, also known as t-cell large granular lymphocyte leukemia, is related to t-cell large granular lymphocyte leukemia and natural killer cell leukemia. An important gene associated with Large Granular Lymphocyte Leukemia is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Carboplatin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow, and related phenotype is Increased shRNA abundance (Z-score > 2).

Related Diseases for Large Granular Lymphocyte Leukemia

Diseases related to Large Granular Lymphocyte Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
id Related Disease Score Top Affiliating Genes
1 t-cell large granular lymphocyte leukemia 12.5
2 natural killer cell leukemia 11.7
3 leukemia 10.9
4 pure red-cell aplasia 10.4
5 lymphoma 10.3
6 rheumatoid arthritis 10.2
7 arthritis 10.2
8 neutropenia 10.2
9 hemolytic anemia 10.1
10 t-cell leukemia 10.1
11 hepatosplenic t-cell lymphoma 10.1
12 heavy chain disease 10.0
13 autoimmune hemolytic anemia 10.0
14 gamma heavy chain disease 10.0
15 hepatitis 10.0
16 prolymphocytic leukemia 10.0
17 autoimmune retinopathy 10.0 IL2RA STAT3
18 cerebral sarcoidosis 9.9 IL2RA STAT3
19 ciliary discoordination, due to random ciliary orientation 9.9 IL2RA MICA
20 hematopoietic stem cell transplantation 9.9
21 myelodysplastic syndrome 9.9
22 chronic active epstein-barr virus infection 9.9
23 felty syndrome 9.9
24 splenomegaly 9.9
25 hairy cell leukemia 9.9
26 purpura 9.9
27 t-cell prolymphocytic leukemia 9.9
28 vulvar nodular hidradenoma 9.9 IL2RA STAT3
29 cutis laxa, autosomal recessive, type ib 9.9 CSF2 MICA STAT3
30 retinal ischemia 9.9 CSF2 IL2RA
31 anterior foramen magnum meningioma 9.8 CSF2 IL2RA
32 birth defects 9.8 CSF2 IL2RA
33 fallopian tube endometriosis 9.8 CSF2 IL2RA
34 joubert syndrome 18 9.8 IL2RA STAT3
35 common variable immunodeficiency 9.8
36 good syndrome 9.8
37 hemoglobinuria 9.8
38 crohn's disease 9.8
39 systemic lupus erythematosus 9.8
40 granuloma annulare 9.8
41 hepatocellular carcinoma 9.8
42 malignant histiocytosis 9.8
43 bacteremia 9.8
44 colitis 9.8
45 neuropathy 9.8
46 hepatitis c virus 9.8
47 lupus erythematosus 9.8
48 encephalitis 9.8
49 aplastic anemia 9.8
50 lymphomatoid granulomatosis 9.8

Graphical network of the top 20 diseases related to Large Granular Lymphocyte Leukemia:



Diseases related to Large Granular Lymphocyte Leukemia

Symptoms & Phenotypes for Large Granular Lymphocyte Leukemia

GenomeRNAi Phenotypes related to Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.78 MICA
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.78 IL2RA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.78 KLRK1 MICA IL2RA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.78 KLRK1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.78 KLRK1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.78 IL2RA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.78 IL2RA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.78 KLRK1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.78 KLRK1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.78 IL2RA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.78 IL2RA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.78 IL2RA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.78 IL2RA MICA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.78 IL2RA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.78 IL2RA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.78 KLRK1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.78 KLRK1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.78 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.78 IL2RA MICA
20 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.78 IL2RA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.78 IL2RA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.78 MICA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.78 IL2RA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.78 MICA
25 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.78 IL2RA

Drugs & Therapeutics for Large Granular Lymphocyte Leukemia

Drugs for Large Granular Lymphocyte Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 238)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 2, Phase 3,Phase 1 41575-94-4 10339178 498142 38904
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
3
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
4
Ofloxacin Approved Phase 3 82419-36-1 4583
5
Cefepime Approved Phase 3 88040-23-7 5479537
6
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
7
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
8
Etoposide Approved Phase 2, Phase 3,Phase 1,Early Phase 1 33419-42-0 36462
9
Iron Approved Phase 3,Phase 1,Phase 2 7439-89-6 23925
10
Morphine Approved, Investigational Phase 3 57-27-2 5288826
11
Fludarabine Approved Phase 2, Phase 3, Phase 1 21679-14-1, 75607-67-9 30751
12
Busulfan Approved, Investigational Phase 2, Phase 3,Early Phase 1 55-98-1 2478
13
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
14
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
15
Ondansetron Approved Phase 3 99614-02-5 4595
16
Thiotepa Approved Phase 2, Phase 3,Phase 1 52-24-4 5453
17
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
18
Dextromethorphan Approved Phase 3 125-71-3 5360696 5362449
19
Dalteparin Approved Phase 3 9041-08-1
20
Darbepoetin alfa Approved, Investigational Phase 3,Phase 2 11096-26-7, 209810-58-2
21
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
22
Guaifenesin Approved, Vet_approved Phase 3,Phase 2 93-14-1 3516
23
Melphalan Approved Phase 2, Phase 3 148-82-3 4053 460612
24
Ginseng Approved, Nutraceutical Phase 3 50647-08-0
25 Analgesics Phase 3,Phase 2
26 Alkylating Agents Phase 2, Phase 3,Phase 1,Early Phase 1
27 Neurotransmitter Agents Phase 3,Phase 1
28 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
29 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 1,Phase 2
30 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
31 Anesthetics Phase 3
32 Anesthetics, Dissociative Phase 3
33 Anesthetics, General Phase 3
34 Anesthetics, Intravenous Phase 3
35 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
36 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
37 Excitatory Amino Acid Antagonists Phase 3
38 Excitatory Amino Acids Phase 3
39 Anti-Infective Agents Phase 3,Phase 2,Phase 1
40 Immunosuppressive Agents Phase 2, Phase 3,Phase 1,Early Phase 1
41 Renal Agents Phase 3,Phase 1,Phase 2
42 Antirheumatic Agents Phase 2, Phase 3,Phase 1,Early Phase 1
43 Antineoplastic Agents, Alkylating Phase 2, Phase 3,Phase 1,Early Phase 1
44 Central Nervous System Depressants Phase 3,Phase 1,Phase 2
45 Cephalosporins Phase 3
46 ferric gluconate Phase 3
47 calcium heparin Phase 3
48 pancreatic polypeptide Phase 3
49 Epoetin alfa Phase 3,Phase 2 113427-24-0
50 Chlorpheniramine, phenylpropanolamine drug combination Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 127)
id Name Status NCT ID Phase
1 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3
2 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3
3 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3
4 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3
5 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3
6 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3
7 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
8 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
9 Darbepoetin Alfa Compared With Epoetin Alfa in Treating Anemia in Patients Receiving Chemotherapy for Cancer Completed NCT00070382 Phase 3
10 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3
11 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3
12 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
13 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3
14 Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer Active, not recruiting NCT00003816 Phase 2, Phase 3
15 Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas Unknown status NCT01805037 Phase 1, Phase 2
16 Cyclosporine in Treating Patients With Low Blood Counts Caused By Hematologic Cancer Completed NCT00031980 Phase 2
17 506U78 in Treating Patients With Chronic Lymphocytic Leukemia That Has Not Responded to Fludarabine or Alkylating Agents Completed NCT00003635 Phase 2
18 Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Completed NCT01093586 Phase 2
19 Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma Completed NCT01258998 Phase 2
20 Combination Chemotherapy Followed By Alemtuzumab in Treating Patients With Chronic Lymphocytic Leukemia or Prolymphocytic Leukemia Completed NCT00278213 Phase 2
21 Peripheral Stem Cell Transplantation in Treating Patients With Breast Cancer or Hematologic Cancer Completed NCT00006225 Phase 1, Phase 2
22 Doxorubicin Hydrochloride Liposome and Bortezomib in Treating Patients With Refractory Hematologic Cancer or Malignant Solid Tumor or Metastatic Breast Cancer Completed NCT00237627 Phase 1, Phase 2
23 Epoetin Alfa or Darbepoetin Alfa in Treating Patients With Anemia Caused by Chemotherapy Completed NCT00416624 Phase 2
24 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00005804 Phase 2
25 Epoetin Alfa in Treating Patients With Anemia Who Are Undergoing Chemotherapy for Cancer Completed NCT00255749 Phase 2
26 Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Refractory Cancer Completed NCT00003406 Phase 1, Phase 2
27 Donor Natural Killer Cells After Donor Stem Cell Transplant in Treating Patients With Advanced Cancer Completed NCT00823524 Phase 1, Phase 2
28 Interleukin-2 Plus Interferon Alfa in Treating Adults With Metastatic Cancer Completed NCT00002504 Phase 2
29 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2
30 A Study of Complete Molecular Response for Chronic Myeloid Leukemia in Chronic Phase Patients, Treated With Dasatinib Completed NCT01342679 Phase 2
31 Prospective, Multicentric, Phase II Randomized Controlled Trial on Two Parallel Groups Comparing the Efficacy of Two Immunosuppressive Drugs (Methotrexate, Cyclophosphamide) in Large Granular Lymphocytes Leukemia Recruiting NCT01976182 Phase 2
32 Alemtuzumab (Campath ) to Treat T-Large Granular Lymphocyte Leukemia Recruiting NCT00345345 Phase 2
33 Dasatinib for Immune Modulation After Donor Stem Cell Transplant for Hematologic Malignancies Recruiting NCT01643603 Phase 1, Phase 2
34 Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies Recruiting NCT01839916 Phase 2
35 Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies Recruiting NCT01760655 Phase 2
36 A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies Recruiting NCT01384513 Phase 2
37 Dasatinib for Modulating Immune System After Autologous Stem Cell Transplants for Multiple Myeloma, Non-Hodgkin, or Hodgkin Lymphoma Recruiting NCT01609816 Phase 1, Phase 2
38 Biological Therapy in Treating Patients at High-Risk or With Lymphoma, Lymphoproliferative Disease, or Malignancies Recruiting NCT00002663 Phase 1, Phase 2
39 CAR-pNK Cell Immunotherapy in CD7 Positive Leukemia and Lymphoma Recruiting NCT02742727 Phase 1, Phase 2
40 Fludarabine Phosphate, Radiation Therapy, and Rituximab in Treating Patients Who Are Undergoing Donor Stem Cell Transplant Followed by Rituximab for High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Active, not recruiting NCT00104858 Phase 2
41 Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer Active, not recruiting NCT00006251 Phase 1, Phase 2
42 Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant Active, not recruiting NCT00078858 Phase 1, Phase 2
43 Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Active, not recruiting NCT01529827 Phase 2
44 Alemtuzumab, Fludarabine Phosphate, and Low-Dose Total Body Irradiation Before Donor Stem Cell Transplantation in Treating Patients With Hematological Malignancies Active, not recruiting NCT00040846 Phase 2
45 Dasatinib in Patients With Chronic Myeloid Leukemia in Chronic Phase Active, not recruiting NCT01802450 Phase 2
46 Effect of Cyclosporine Therapy on Gene Expression in Patients With Large Granular Lymphocyte Leukemia Terminated NCT00363779 Phase 2
47 Methotrexate Followed by Fludarabine in Patients With T-Cell Large Granular Lymphocytic Leukemia Terminated NCT00278265 Phase 2
48 Tipifarnib in Treating Patients With Anemia or Neutropenia and Large Granular Lymphocyte Leukemia Terminated NCT00360776 Phase 2
49 Alemtuzumab in Myelodysplastic Syndrome (MDS), Aplastic Anemia, and T-Cell Large Granular Lymphocytic Leukemia (T-GL) Terminated NCT01191749 Phase 2
50 Methotrexate With or Without Cyclophosphamide in Treating Patients With Lymphocytic Leukemia Terminated NCT00003910 Phase 2

Search NIH Clinical Center for Large Granular Lymphocyte Leukemia

Genetic Tests for Large Granular Lymphocyte Leukemia

Anatomical Context for Large Granular Lymphocyte Leukemia

MalaCards organs/tissues related to Large Granular Lymphocyte Leukemia:

39
T Cells, Bone, Bone Marrow, Spleen, Neutrophil, Nk Cells, B Cells

Publications for Large Granular Lymphocyte Leukemia

Articles related to Large Granular Lymphocyte Leukemia:

(show top 50) (show all 229)
id Title Authors Year
1
Distinguishing Between Hepatosplenic T-cell Lymphoma and I^I' T-cell Large Granular Lymphocytic Leukemia: A Clinicopathologic, Immunophenotypic, and Molecular Analysis. ( 27755009 )
2017
2
Gamma Heavy Chain Disease with T-cell Large Granular Lymphocytic Leukemia: A Case Report and Review of the Literature. ( 26875967 )
2016
3
High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia. ( 27697773 )
2016
4
Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia. ( 26199174 )
2016
5
A population-based study of large granular lymphocyte leukemia. ( 27494824 )
2016
6
Prolonged complete hematologic response in relapsed/refractory T-large granular lymphocyte leukemia after bendamustine treatment. ( 27896231 )
2016
7
Single-center Series of Bone Marrow Biopsy-Defined Large Granular Lymphocyte Leukemia: High Rates of Sustained Response to Oral Methotrexate. ( 27640075 )
2016
8
Donor-Derived T-Cell Large Granular Lymphocytic Leukemia in a Patient With Peripheral T-Cell Lymphoma. ( 27496109 )
2016
9
Cell size variations of large granular lymphocyte leukemia: Implication of a small cell subtype of granular lymphocyte leukemia with STAT3 mutations. ( 27064362 )
2016
10
Moderate-dose cyclophosphamide in the treatment of relapsed/refractory T-cell large granular lymphocytic leukemia-associated pure red cell aplasia. ( 27077768 )
2016
11
AOHE: manuscript AOHE-D-16-00564 paroxysmal nocturnal hemoglobinuria with autoimmune hemolytic anemia following eculizumab therapy-with large granular lymphocytic leukemia. ( 27449072 )
2016
12
Population-based analyses among 184 patients diagnosed with large granular lymphocyte leukemia in the Netherlands between 2001 and 2013. ( 27055870 )
2016
13
The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia. ( 25281507 )
2015
14
Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia. ( 26252351 )
2015
15
Gamma heavy chain disease associated with large granular lymphocytic leukemia: A report of two cases and review of the literature. ( 26222587 )
2015
16
Hematopoietic stem cell transplantation for T-cell large granular lymphocyte leukemia: a retrospective study of the European Society for Blood and Marrow Transplantation. ( 26460210 )
2015
17
Hepatic Lesions Caused by Large Granular Lymphocyte Leukemia in Fischer 344 Rats: Similar Morphologic Features and Morphogenesis to Those of Nodular Regenerative Hyperplasia (NRH) in the Human Liver. ( 25903270 )
2015
18
Good syndrome presenting with CD8+ T-Cell large granular lymphocyte leukemia. ( 26429871 )
2015
19
High rate of both hematopoietic and solid tumors associated with large granular lymphocyte leukemia. ( 24882263 )
2014
20
Lack of common TCRA and TCRB clonotypes in CD8(+)/TCRI+I^(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL. ( 24413066 )
2014
21
Lymphoma with features intermediate between aggressive T-large granular lymphocytic leukemia and hepatosplenic T-cell lymphoma: a diagnostic dilemma? ( 24524924 )
2014
22
Submicroscopic genomic rearrangements change gene expression in T-cell large granular lymphocyte leukemia. ( 24649974 )
2014
23
Acquired inhibitors to factor VIII and fibrinogen in the setting of T-cell large granular lymphocyte leukemia: a case report and review of the literature. ( 25396761 )
2014
24
Concurrent administration of darbepoetin alfa, cyclosporine A, and prednisolone is useful for T cell large granular lymphocyte leukemia associated with myelodysplastic syndrome complicated by Coombs-negative hemolytic anemia. ( 24756696 )
2014
25
Coexistence of ALK-anaplastic large cell lymphoma and CD4+ T cell large granular lymphocytic leukemia. ( 25100004 )
2014
26
Uncovering the pathogenesis of large granular lymphocytic leukemia-novel STAT3 and STAT5b mutations. ( 24512550 )
2014
27
T-Cell Large Granular Lymphocyte Leukemia in the Lower Eyelid. ( 25198396 )
2014
28
The pathogenesis and treatment of large granular lymphocyte leukemia. ( 24679833 )
2014
29
T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: Metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities. ( 25238936 )
2014
30
Distinct effect of cyclophosphamide and cyclosporine on pure red cell aplasia associated with T-cell large granular lymphocyte leukemia. ( 25466263 )
2014
31
CD4(-)/CD8(-) variant of T-cell large granular lymphocytic leukemia or hepatosplenic T-cell lymphoma: a clinicopathologic dilemma. ( 23800602 )
2013
32
Familial CD3+ T Large Granular Lymphocyte Leukemia: Evidence that Genetic Predisposition and Antigen Selection Promote Clonal Cytotoxic T-Cell Responses. ( 24180333 )
2013
33
Targeting IL-15 in large granular lymphocyte leukemia. ( 23634735 )
2013
34
Large granular lymphocyte leukemia and lymphomatoid granulomatosis in the same patient: fortuitous association? ( 22799270 )
2013
35
Does IL-15 have a causative role in large granular lymphocyte leukemia? ( 23444952 )
2013
36
Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation. ( 24317090 )
2013
37
Fibrosis and subsequent cytopenias are associated with basic fibroblast growth factor-deficient pluripotent mesenchymal stromal cells in large granular lymphocyte leukemia. ( 24014875 )
2013
38
T-cell large granular lymphocyte leukemia in a child with anemia and Crohn's disease. ( 23409990 )
2013
39
Unusual concurrence of T-cell large granular lymphocytic leukemia with Franklin disease (gamma heavy chain disease) manifested with massive splenomegaly. ( 22694793 )
2013
40
Chronic active Epstein-Barr virus infection with progression to large granular lymphocytic leukemia. ( 23731478 )
2013
41
STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia. ( 24283217 )
2013
42
Diagnosis of large granular lymphocytic leukemia in a patient previously treated for acute myeloblastic leukemia. ( 24416499 )
2013
43
Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemia. ( 23515927 )
2013
44
STAT3 gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia. ( 24350896 )
2013
45
Diagnosing large granular lymphocyte leukemia is bloody difficult. ( 23025294 )
2013
46
Developing an in vitro model of T cell type of large granular lymphocyte leukemia. ( 24183305 )
2013
47
STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia. ( 23563237 )
2013
48
Deep sequencing of the T-cell receptor repertoire in CD8+ T-large granular lymphocyte leukemia identifies signature landscapes. ( 24149287 )
2013
49
Peripheral blood immunophenotypic analysis as a diagnostic tool for large granular lymphocyte leukemia. ( 22938095 )
2013
50
Long-term remission of T-cell large granular lymphocyte leukemia associated with rheumatoid arthritis after rituximab therapy. ( 23869084 )
2013

Variations for Large Granular Lymphocyte Leukemia

Expression for Large Granular Lymphocyte Leukemia

Search GEO for disease gene expression data for Large Granular Lymphocyte Leukemia.

Pathways for Large Granular Lymphocyte Leukemia

Pathways related to Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 CSF2 IL2RA KIR2DL3 KLRK1 MICA STAT3
2
Show member pathways
12.46 IL2RA KIR2DL3 MICA
3
Show member pathways
11.74 CSF2 IL2RA STAT3
4
Show member pathways
11.64 IL2RA STAT3
5 11.56 CSF2 IL2RA
6
Show member pathways
11.54 CSF2 STAT3
7 11.5 IL2RA STAT3
8 11.46 KIR2DL3 KLRK1 MICA
9 11.44 IL2RA KLRK1
10
Show member pathways
11.4 CSF2 IL2RA
11
Show member pathways
11.4 CSF2 KIR2DL3 KLRK1 MICA
12 11.34 IL2RA STAT3
13 11.2 CSF2 IL2RA KLRK1
14 11.18 CSF2 STAT3
15
Show member pathways
11.12 IL2RA STAT3
16
Show member pathways
11.06 CSF2 IL2RA
17
Show member pathways
10.87 IL2RA STAT3
18 10.82 IL2RA STAT3
19 10.37 CSF2 STAT3

GO Terms for Large Granular Lymphocyte Leukemia

Cellular components related to Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.8 IL2RA KLRK1 MICA

Biological processes related to Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.13 CSF2 IL2RA KIR2DL3
2 regulation of immune response GO:0050776 8.8 KIR2DL3 KLRK1 MICA

Molecular functions related to Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.62 CSF2 IL2RA

Sources for Large Granular Lymphocyte Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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