MCID: LRG008
MIFTS: 35

Large Granular Lymphocyte Leukemia malady

Rare diseases, Immune diseases categories

Aliases & Classifications for Large Granular Lymphocyte Leukemia

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Large Granular Lymphocyte Leukemia, Aliases & Descriptions:

Name: Large Granular Lymphocyte Leukemia 41
T-Cell Large Granular Lymphocyte Leukemia 41 60
Proliferation of Large Granular Lymphocytes 41
Leukemia, Large Granular Lymphocytic 60
 
T-Cell Lgl Leukemia 41
Lgl Leukemia 41
T-Lgl 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Immune diseases


Summaries for Large Granular Lymphocyte Leukemia

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NIH Rare Diseases:41 Large granular lymphocyte (lgl) leukemia is a rare cancer of a type of white blood cells called lymphocytes. lgl leukemia causes a slow increase in white blood cells called t lymphocytes, or t cells, which originate in the lymph system and bone marrow and help to fight infection. this disease usually affects people in their sixties. symptoms include anemia; low levels of platelets (thrombocytopenia) and infection-fighting neutrophils (neutropenia) in the blood; and an enlarged spleen. about one-third of patients are asymptomatic at the time of diagnosis. the exact cause of lgl leukemia is unknown. doctors can diagnose this disease through a bone marrow biopsy, or by using a specialized technique in which various types of blood or bone marrow cells are separated, identified, and counted. last updated: 8/2/2011

MalaCards based summary: Large Granular Lymphocyte Leukemia, also known as t-cell large granular lymphocyte leukemia, is related to leukemia and t-cell leukemia. An important gene associated with Large Granular Lymphocyte Leukemia is KIR2DL1 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1), and among its related pathways are Class I MHC mediated antigen processing and presentation and Signaling by FGFR. The compounds tuberculin and cuprophan have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow.

Related Diseases for Large Granular Lymphocyte Leukemia

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Diseases related to Large Granular Lymphocyte Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.6KLRK1, IL2RA, LBR
2t-cell leukemia30.8IL2RA, LBR
3rheumatoid arthritis30.7KLRK1, KIR2DL1, IL2RA, LBR
4celiac disease30.4MICA, KLRK1
5systemic lupus erythematosus30.2KLRK1, IL2RA, LBR
6behcet's disease30.1KIR2DL1, IL2RA, LBR
7t-cell large granular lymphocyte leukemia11.2
8pure red-cell aplasia10.9
9arthritis10.7
10neutropenia10.7
11hemolytic anemia10.6
12natural killer cell leukemia10.6
13hepatitis10.5
14prolymphocytic leukemia10.5
15hepatosplenic t-cell lymphoma10.5
16myelodysplastic syndrome10.4
17autoimmune hemolytic anemia10.4
18myeloma10.4
19purpura10.4
20chronic active epstein-barr virus infection10.4
21splenomegaly10.4
22hepatocellular carcinoma10.3
23hepatitis c virus10.3
24aplastic anemia10.3
25anaplastic large cell lymphoma10.3
26autoimmune hepatitis10.3
27b-cell lymphomas10.3
28chronic lymphocytic leukemia10.3
29chronic myelomonocytic leukemia10.3
30common variable immunodeficiency10.3
31crohn's disease10.3
32granuloma annulare10.3
33hematopoietic stem cell transplantation10.3
34lymphomatoid granulomatosis10.3
35myelofibrosis10.3
36thrombocytopenia10.3
37ulcerative colitis10.3
38hepatitis c10.3
39gamma heavy chain disease10.3
40protein-losing enteropathy10.3
41malignant histiocytosis10.3
42lambert-eaton myasthenic syndrome10.3
43sjogren's syndrome10.3
44felty's syndrome10.3
45candidiasis10.3
46colitis10.3
47encephalitis10.3
48heavy chain disease10.3
49histiocytosis10.3
50lupus erythematosus10.3

Graphical network of the top 20 diseases related to Large Granular Lymphocyte Leukemia:



Diseases related to large granular lymphocyte leukemia

Symptoms for Large Granular Lymphocyte Leukemia

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Drugs & Therapeutics for Large Granular Lymphocyte Leukemia

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Drug clinical trials:

Search ClinicalTrials for Large Granular Lymphocyte Leukemia

Search NIH Clinical Center for Large Granular Lymphocyte Leukemia

Genetic Tests for Large Granular Lymphocyte Leukemia

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Anatomical Context for Large Granular Lymphocyte Leukemia

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MalaCards organs/tissues related to Large Granular Lymphocyte Leukemia:

31
T cells, Bone, Bone marrow, Spleen, Neutrophil, Nk cells, B cells, Liver, Skin

Animal Models for Large Granular Lymphocyte Leukemia or affiliated genes

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Publications for Large Granular Lymphocyte Leukemia

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Articles related to Large Granular Lymphocyte Leukemia:

(show top 50)    (show all 209)
idTitleAuthorsYear
1
The pathogenesis and treatment of large granular lymphocyte leukemia. (24679833)
2014
2
Lack of common TCRA and TCRB clonotypes in CD8(+)/TCRI+I^(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL. (24413066)
2014
3
T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: Metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities. (25238936)
2014
4
Acquired inhibitors to factor VIII and fibrinogen in the setting of T-cell large granular lymphocyte leukemia: a case report and review of the literature. (25396761)
2014
5
Concurrent administration of darbepoetin alfa, cyclosporine A, and prednisolone is useful for T cell large granular lymphocyte leukemia associated with myelodysplastic syndrome complicated by Coombs-negative hemolytic anemia. (24756696)
2014
6
Chronic active Epstein-Barr virus infection with progression to large granular lymphocytic leukemia. (23731478)
2013
7
STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia. (23563237)
2013
8
Large granular lymphocyte leukemia and lymphomatoid granulomatosis in the same patient: fortuitous association? (22799270)
2013
9
Large granular lymphocytic leukemia associated with Lambert-Eaton Myasthenic Syndrome: A case report. (24371773)
2013
10
Treatment of T-cell large granular lymphocyte leukemia with cyclosporine A: experience in a Chinese single institution. (23395383)
2013
11
STAT3 mutations are highly specific for large granular lymphocytic leukemia. (23207521)
2013
12
Targeting IL-15 in large granular lymphocyte leukemia. (23634735)
2013
13
Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemia. (23515927)
2013
14
Deep sequencing of the T-cell receptor repertoire in CD8+ T-large granular lymphocyte leukemia identifies signature landscapes. (24149287)
2013
15
Diagnosing large granular lymphocyte leukemia is bloody difficult. (23025294)
2013
16
Large granular lymphocytic leukemia: a treatable form of refractory celiac disease. (22922421)
2012
17
Autoimmune manifestations in large granular lymphocyte leukemia. (22999943)
2012
18
Extracorporeal photopheresis as a curative treatment strategy in non epidermotropic T-cell lymphoma and large granular lymphocyte leukemia. (22422944)
2012
19
Asymptomatic T-cell large granular lymphocyte leukemia with an unusual immunophenotype. (24765467)
2012
20
Lymphocytosis: T-cell large granular lymphocyte leukemia. (23082329)
2012
21
Dynamical and structural analysis of a T cell survival network identifies novel candidate therapeutic targets for large granular lymphocyte leukemia. (22102804)
2011
22
Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia. (21865345)
2011
23
Long-term safety and efficacy of cyclosporin A therapy for T-cell large granular lymphocyte leukemia. (20038217)
2010
24
A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia. (19660811)
2010
25
T/NK large granular lymphocyte leukemia and coexisting monoclonal B-cell lymphocytosis-like proliferations. An unrecognized and frequent association. (20472852)
2010
26
Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia associated with an occult large granular lymphocyte leukemia. (17915315)
2008
27
Large granular lymphocyte leukemia after renal transplantation: an immunologic, immunohistochemical, and genotypic study. (17220805)
2007
28
T-gamma delta large granular lymphocyte leukemia preceded by pure red cell aplasia and complicated with hemophagocytic syndrome caused by Epstein-Barr virus infection. (16755095)
2006
29
Pathogenesis of neutropenia in large granular lymphocyte leukemia and Felty syndrome. (16530306)
2006
30
Histopathology of the spleen in T-cell large granular lymphocyte leukemia and T-cell prolymphocytic leukemia: a comparative review. (15958859)
2005
31
T-cell large granular lymphocyte leukemias have multiple phenotypic abnormalities involving pan-T-cell antigens and receptors for MHC molecules. (16416744)
2005
32
Reversible paraneoplastic neuropathy associated with T-cell large granular lymphocyte leukemia. (15304606)
2004
33
T-gamma large granular lymphocyte leukemia associated with amegakaryocytic thrombocytopenic purpura, SjAPgren's syndrome, and polyglandular autoimmune syndrome type II, with subsequent development of pure red cell aplasia. (11835350)
2002
34
Deletion 6q as a recurrent chromosomal aberration in T-cell large granular lymphocyte leukemia. (12547164)
2002
35
Pathologic quiz case: chronic anemia with red cell aplasia and lymphocytosis in a middle-aged man. T-cell large granular lymphocyte leukemia. (12503585)
2002
36
Large granular lymphocyte leukemia: case report of chronic neutropenia and rheumatoid arthritis-like symptoms in a child. (11200497)
2001
37
Large granular lymphocyte leukemia/lymphoma in six cats. (9754542)
1998
38
Induction of clinical remission in T-large granular lymphocyte leukemia with cyclosporin A, monitored by use of immunophenotyping with Vbeta antibodies. (9519776)
1998
39
Cytokine expression and tumorigenicity of large granular lymphocytic leukemia cells from mice transgenic for the tax gene of human T-cell leukemia virus type I. (9226179)
1997
40
Humoral immune abnormalities in T-cell large granular lymphocyte leukemia. (9031118)
1996
41
Epstein-Barr virus-associated CD3- large granular lymphocyte leukemia presenting with polycranial nerve palsies. (8639870)
1996
42
Pure red blood cell aplasia associated with parvovirus B19 infection in large granular lymphocyte leukemia. (8605376)
1996
43
Epstein-Barr virus-associated large granular lymphocyte leukemia with cutaneous infiltration. (8040410)
1994
44
Epstein-Barr virus-associated natural killer-large granular lymphocyte leukemia. (8088773)
1994
45
Failure to detect Epstein-Barr virus DNA in peripheral blood mononuclear cells of most patients with large granular lymphocyte leukemia. (8387836)
1993
46
Transplantation of large granular lymphocyte leukemia in congenitally athymic rats. (1621333)
1992
47
Effects of large granular lymphocyte leukemia on bone in F344 rats. (2278127)
1990
48
Rearrangement and expression of T-cell receptor genes in large granular lymphocyte leukemia. (3345349)
1988
49
Large granular lymphocyte leukemia. Report of 38 cases and review of the literature. (3626848)
1987
50
Large granular lymphocyte leukemia. A heterogeneous lymphocytic leukemia in F344 rats. (6837719)
1983

Variations for Large Granular Lymphocyte Leukemia

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Expression for genes affiliated with Large Granular Lymphocyte Leukemia

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Search GEO for disease gene expression data for Large Granular Lymphocyte Leukemia.

Pathways for genes affiliated with Large Granular Lymphocyte Leukemia

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Compounds for genes affiliated with Large Granular Lymphocyte Leukemia

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Compounds related to Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

(show all 21)
idCompoundScoreTop Affiliating Genes
1tuberculin439.7IL2RA, LBR
2cuprophan439.7IL2RA, LBR
3phorbol 12,13-dibutyrate439.7LBR, IL2RA
4okt3439.7IL2RA, LBR
5con a439.6IL2RA, LBR
6diethyl dithiocarbamate439.6LBR, IL2RA
7sodium arsenite439.6IL2RA, LBR
8ouabain43 1210.6IL2RA, LBR
9infliximab43 49 1211.6LBR, IL2RA
10pentoxifylline43 1210.6IL2RA, LBR
11neopterin439.6LBR, IL2RA
12malondialdehyde439.5LBR, IL2RA
13cadmium43 2410.5IL2RA, LBR
14melatonin43 28 59 24 1213.5IL2RA, LBR
15vitamin-e439.4LBR, IL2RA
16mifepristone43 28 59 1212.4IL2RA, LBR
17rantes439.3IL2RA, LBR
18nifedipine43 28 49 1212.2LBR, IL2RA
19ionomycin439.0IL2RA, LBR
20arginine438.8KLRK1, IL2RA, LBR
21tyrosine438.7LBR, IL2RA, KIR2DL3, KIR2DL1

GO Terms for genes affiliated with Large Granular Lymphocyte Leukemia

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Cellular components related to Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.8KIR2DL1, KIR2DL3, MICA

Biological processes related to Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:00507769.6KIR2DL1, KIR2DL3
2immune responseGO:00069558.8KIR2DL1, KIR2DL3, IL2RA

Molecular functions related to Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor activityGO:00048729.6KIR2DL1, KIR2DL3
2antigen bindingGO:00038238.9KIR2DL3, MICA

Products for genes affiliated with Large Granular Lymphocyte Leukemia

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Sources for Large Granular Lymphocyte Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet