MCID: LRG008
MIFTS: 40

Large Granular Lymphocyte Leukemia malady

Rare diseases, Immune diseases categories
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Summaries for Large Granular Lymphocyte Leukemia

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NIH Rare Diseases:42 Large granular lymphocyte (lgl) leukemia is a rare cancer of a type of white blood cells called lymphocytes. lgl leukemia causes a slow increase in white blood cells called t lymphocytes, or t cells, which originate in the lymph system and bone marrow and help to fight infection. this disease usually affects people in their sixties. symptoms include anemia; low levels of platelets (thrombocytopenia) and infection-fighting neutrophils (neutropenia) in the blood; and an enlarged spleen. about one-third of patients are asymptomatic at the time of diagnosis. the exact cause of lgl leukemia is unknown. doctors can diagnose this disease through a bone marrow biopsy, or by using a specialized technique in which various types of blood or bone marrow cells are separated, identified, and counted. last updated: 8/2/2011

MalaCards based summary: Large Granular Lymphocyte Leukemia, also known as t-cell large granular lymphocyte leukemia, is related to leukemia and t-cell leukemia. An important gene associated with Large Granular Lymphocyte Leukemia is KIR2DL1 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1), and among its related pathways are Class I MHC mediated antigen processing and presentation and Signaling by FGFR. The compounds tuberculin and cuprophan have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow.

Aliases & Classifications for Large Granular Lymphocyte Leukemia

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Large Granular Lymphocyte Leukemia, Aliases & Descriptions:

Name: Large Granular Lymphocyte Leukemia 42
T-Cell Large Granular Lymphocyte Leukemia 42 62
 
Leukemia, Large Granular Lymphocytic 62
Lgl Leukemia 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Immune diseases


Related Diseases for Large Granular Lymphocyte Leukemia

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Diseases related to Large Granular Lymphocyte Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.6IL2RA, LBR, KLRK1
2t-cell leukemia30.8LBR, IL2RA
3rheumatoid arthritis30.7LBR, KLRK1, KIR2DL1, IL2RA
4celiac disease30.4KLRK1, MICA
5systemic lupus erythematosus30.2IL2RA, KLRK1, LBR
6multiple sclerosis30.2IL2RA, LBR, KLRK1
7behcet's disease30.2KIR2DL1, LBR, IL2RA
8t-cell large granular lymphocyte leukemia11.2
9pure red-cell aplasia10.9
10arthritis10.7
11neutropenia10.7
12hemolytic anemia10.6
13natural killer cell leukemia10.6
14prolymphocytic leukemia10.5
15hepatosplenic t-cell lymphoma10.5
16hepatitis10.4
17myelodysplastic syndromes10.4
18autoimmune hemolytic anemia10.4
19hairy cell leukemia10.4
20myeloma10.4
21purpura10.4
22chronic active epstein-barr virus infection10.4
23splenomegaly10.4
24t-cell prolymphocytic leukemia10.4
25anaplastic large cell lymphoma10.3
26aplastic anemia10.3
27autoimmune hepatitis10.3
28b-cell lymphomas10.3
29chronic lymphocytic leukemia10.3
30chronic myelomonocytic leukemia10.3
31common variable immunodeficiency10.3
32crohn's disease10.3
33graft versus host disease10.3
34granuloma annulare10.3
35hematopoietic stem cell transplantation10.3
36hepatocellular carcinoma10.3
37lymphomatoid granulomatosis10.3
38myelofibrosis10.3
39thrombocytopenia10.3
40ulcerative colitis10.3
41hepatitis c10.3
42lambert-eaton myasthenic syndrome10.3
43sjogren's syndrome10.3
44gamma heavy chain disease10.3
45protein-losing enteropathy10.3
46malignant histiocytosis10.3
47felty's syndrome10.3
48candidiasis10.3
49colitis10.3
50encephalitis10.3

Graphical network of the top 20 diseases related to Large Granular Lymphocyte Leukemia:



Diseases related to large granular lymphocyte leukemia

Symptoms for Large Granular Lymphocyte Leukemia

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Drugs & Therapeutics for Large Granular Lymphocyte Leukemia

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Drug clinical trials:

Search ClinicalTrials for Large Granular Lymphocyte Leukemia

Search NIH Clinical Center for Large Granular Lymphocyte Leukemia

Genetic Tests for Large Granular Lymphocyte Leukemia

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Anatomical Context for Large Granular Lymphocyte Leukemia

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MalaCards organs/tissues related to Large Granular Lymphocyte Leukemia:

32
T cells, Bone, Bone marrow, Spleen, Neutrophil, Nk cells, B cells, Skin

Animal Models for Large Granular Lymphocyte Leukemia or affiliated genes

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Publications for Large Granular Lymphocyte Leukemia

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Articles related to Large Granular Lymphocyte Leukemia:

(show top 50)    (show all 207)
idTitleAuthorsYear
1
The pathogenesis and treatment of large granular lymphocyte leukemia. (24679833)
2014
2
Lack of common TCRA and TCRB clonotypes in CD8(+)/TCRI+I^(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL. (24413066)
2014
3
T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: Metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities. (25238936)
2014
4
Acquired inhibitors to factor VIII and fibrinogen in the setting of T-cell large granular lymphocyte leukemia: a case report and review of the literature. (25396761)
2014
5
Concurrent administration of darbepoetin alfa, cyclosporine A, and prednisolone is useful for T cell large granular lymphocyte leukemia associated with myelodysplastic syndrome complicated by Coombs-negative hemolytic anemia. (24756696)
2014
6
Chronic active Epstein-Barr virus infection with progression to large granular lymphocytic leukemia. (23731478)
2013
7
STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia. (23563237)
2013
8
Large granular lymphocyte leukemia and lymphomatoid granulomatosis in the same patient: fortuitous association? (22799270)
2013
9
Large granular lymphocytic leukemia associated with Lambert-Eaton Myasthenic Syndrome: A case report. (24371773)
2013
10
Treatment of T-cell large granular lymphocyte leukemia with cyclosporine A: experience in a Chinese single institution. (23395383)
2013
11
STAT3 mutations are highly specific for large granular lymphocytic leukemia. (23207521)
2013
12
Targeting IL-15 in large granular lymphocyte leukemia. (23634735)
2013
13
Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemia. (23515927)
2013
14
Deep sequencing of the T-cell receptor repertoire in CD8+ T-large granular lymphocyte leukemia identifies signature landscapes. (24149287)
2013
15
Large granular lymphocytic leukemia: a treatable form of refractory celiac disease. (22922421)
2012
16
Autoimmune manifestations in large granular lymphocyte leukemia. (22999943)
2012
17
Extracorporeal photopheresis as a curative treatment strategy in non epidermotropic T-cell lymphoma and large granular lymphocyte leukemia. (22422944)
2012
18
Asymptomatic T-cell large granular lymphocyte leukemia with an unusual immunophenotype. (24765467)
2012
19
Lymphocytosis: T-cell large granular lymphocyte leukemia. (23082329)
2012
20
Dynamical and structural analysis of a T cell survival network identifies novel candidate therapeutic targets for large granular lymphocyte leukemia. (22102804)
2011
21
Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia. (21865345)
2011
22
Long-term safety and efficacy of cyclosporin A therapy for T-cell large granular lymphocyte leukemia. (20038217)
2010
23
A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia. (19660811)
2010
24
T/NK large granular lymphocyte leukemia and coexisting monoclonal B-cell lymphocytosis-like proliferations. An unrecognized and frequent association. (20472852)
2010
25
Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia associated with an occult large granular lymphocyte leukemia. (17915315)
2008
26
Large granular lymphocyte leukemia after renal transplantation: an immunologic, immunohistochemical, and genotypic study. (17220805)
2007
27
T-gamma delta large granular lymphocyte leukemia preceded by pure red cell aplasia and complicated with hemophagocytic syndrome caused by Epstein-Barr virus infection. (16755095)
2006
28
Pathogenesis of neutropenia in large granular lymphocyte leukemia and Felty syndrome. (16530306)
2006
29
Histopathology of the spleen in T-cell large granular lymphocyte leukemia and T-cell prolymphocytic leukemia: a comparative review. (15958859)
2005
30
T-cell large granular lymphocyte leukemias have multiple phenotypic abnormalities involving pan-T-cell antigens and receptors for MHC molecules. (16416744)
2005
31
Reversible paraneoplastic neuropathy associated with T-cell large granular lymphocyte leukemia. (15304606)
2004
32
T-gamma large granular lymphocyte leukemia associated with amegakaryocytic thrombocytopenic purpura, SjAPgren's syndrome, and polyglandular autoimmune syndrome type II, with subsequent development of pure red cell aplasia. (11835350)
2002
33
Deletion 6q as a recurrent chromosomal aberration in T-cell large granular lymphocyte leukemia. (12547164)
2002
34
Pathologic quiz case: chronic anemia with red cell aplasia and lymphocytosis in a middle-aged man. T-cell large granular lymphocyte leukemia. (12503585)
2002
35
Large granular lymphocyte leukemia: case report of chronic neutropenia and rheumatoid arthritis-like symptoms in a child. (11200497)
2001
36
Large granular lymphocyte leukemia/lymphoma in six cats. (9754542)
1998
37
Induction of clinical remission in T-large granular lymphocyte leukemia with cyclosporin A, monitored by use of immunophenotyping with Vbeta antibodies. (9519776)
1998
38
Cytokine expression and tumorigenicity of large granular lymphocytic leukemia cells from mice transgenic for the tax gene of human T-cell leukemia virus type I. (9226179)
1997
39
Humoral immune abnormalities in T-cell large granular lymphocyte leukemia. (9031118)
1996
40
Epstein-Barr virus-associated CD3- large granular lymphocyte leukemia presenting with polycranial nerve palsies. (8639870)
1996
41
Pure red blood cell aplasia associated with parvovirus B19 infection in large granular lymphocyte leukemia. (8605376)
1996
42
Clostridium septicum bacteremia in a patient with large granular lymphocyte leukemia. (7552816)
1995
43
Epstein-Barr virus-associated large granular lymphocyte leukemia with cutaneous infiltration. (8040410)
1994
44
Epstein-Barr virus-associated natural killer-large granular lymphocyte leukemia. (8088773)
1994
45
Failure to detect Epstein-Barr virus DNA in peripheral blood mononuclear cells of most patients with large granular lymphocyte leukemia. (8387836)
1993
46
Transplantation of large granular lymphocyte leukemia in congenitally athymic rats. (1621333)
1992
47
Effects of large granular lymphocyte leukemia on bone in F344 rats. (2278127)
1990
48
Rearrangement and expression of T-cell receptor genes in large granular lymphocyte leukemia. (3345349)
1988
49
Large granular lymphocyte leukemia. Report of 38 cases and review of the literature. (3626848)
1987
50
Large granular lymphocyte leukemia. A heterogeneous lymphocytic leukemia in F344 rats. (6837719)
1983

Variations for Large Granular Lymphocyte Leukemia

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Expression for genes affiliated with Large Granular Lymphocyte Leukemia

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Expression patterns in normal tissues for genes affiliated with Large Granular Lymphocyte Leukemia

Search GEO for disease gene expression data for Large Granular Lymphocyte Leukemia.

Pathways for genes affiliated with Large Granular Lymphocyte Leukemia

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Compounds for genes affiliated with Large Granular Lymphocyte Leukemia

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Compounds related to Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1tuberculin449.7IL2RA, LBR
2cuprophan449.7IL2RA, LBR
3phorbol 12,13-dibutyrate449.7LBR, IL2RA
4okt3449.7IL2RA, LBR
5con a449.6IL2RA, LBR
6diethyl dithiocarbamate449.6LBR, IL2RA
7sodium arsenite449.6IL2RA, LBR
8ouabain44 1110.6IL2RA, LBR
9infliximab44 50 1111.6LBR, IL2RA
10pentoxifylline44 1110.6IL2RA, LBR
11neopterin449.6LBR, IL2RA
12malondialdehyde449.5LBR, IL2RA
13cadmium44 2410.5IL2RA, LBR
14melatonin44 28 61 24 1113.5IL2RA, LBR
15vitamin-e449.4LBR, IL2RA
16mifepristone44 28 61 1112.4IL2RA, LBR
17rantes449.3IL2RA, LBR
18nifedipine44 28 50 1112.2LBR, IL2RA
19ionomycin449.0IL2RA, LBR
20arginine448.8KLRK1, IL2RA, LBR
21tyrosine448.7LBR, IL2RA, KIR2DL3, KIR2DL1

GO Terms for genes affiliated with Large Granular Lymphocyte Leukemia

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Cellular components related to Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.8KIR2DL1, KIR2DL3, MICA

Biological processes related to Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:0507769.6KIR2DL1, KIR2DL3
2immune responseGO:0069558.8KIR2DL1, KIR2DL3, IL2RA

Molecular functions related to Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor activityGO:0048729.6KIR2DL1, KIR2DL3
2antigen bindingGO:0038238.9KIR2DL3, MICA

Products for genes affiliated with Large Granular Lymphocyte Leukemia

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Sources for Large Granular Lymphocyte Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet