MCID: LRG008
MIFTS: 39

Large Granular Lymphocyte Leukemia

Categories: Rare diseases, Immune diseases, Cancer diseases

Aliases & Classifications for Large Granular Lymphocyte Leukemia

MalaCards integrated aliases for Large Granular Lymphocyte Leukemia:

Name: Large Granular Lymphocyte Leukemia 50
T-Cell Large Granular Lymphocyte Leukemia 50 69
Leukemia, Large Granular Lymphocytic 69
Lgl Leukemia 50

Classifications:



Summaries for Large Granular Lymphocyte Leukemia

NIH Rare Diseases : 50 large granular lymphocyte (lgl) leukemia is a rare cancer of a type of white blood cells called lymphocytes. lgl leukemia causes a slow increase in white blood cells called t lymphocytes, or t cells, which originate in the lymph system and bone marrow and help to fight infection. this disease usually affects people in their sixties. symptoms include anemia; low levels of platelets (thrombocytopenia) and infection-fighting neutrophils (neutropenia) in the blood; and an enlarged spleen. about one-third of patients are asymptomatic at the time of diagnosis. the exact cause of lgl leukemia is unknown. doctors can diagnose this disease through a bone marrow biopsy, or by using a specialized technique in which various types of blood or bone marrow cells are separated, identified, and counted. last updated: 8/2/2011

MalaCards based summary : Large Granular Lymphocyte Leukemia, also known as t-cell large granular lymphocyte leukemia, is related to hemolytic anemia and t-cell large granular lymphocyte leukemia. An important gene associated with Large Granular Lymphocyte Leukemia is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Innate Immune System and Immune response Role of DAP12 receptors in NK cells. The drugs Cefepime and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow, and related phenotype is Increased shRNA abundance (Z-score > 2).

Related Diseases for Large Granular Lymphocyte Leukemia

Diseases related to Large Granular Lymphocyte Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
id Related Disease Score Top Affiliating Genes
1 hemolytic anemia 29.3 CSF2 IL2RA
2 t-cell large granular lymphocyte leukemia 12.4
3 natural killer cell leukemia 11.7
4 leukemia 10.9
5 pure red-cell aplasia 10.4
6 lymphoma 10.3
7 rheumatoid arthritis 10.2
8 arthritis 10.2
9 neutropenia 10.2
10 autoimmune lymphoproliferative syndrome due to ctla4 haploinsuffiency 10.2 IL2RA STAT3
11 cerebral sarcoidosis 10.1 IL2RA STAT3
12 vulvar nodular hidradenoma 10.1 IL2RA STAT3
13 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 10.1 IL2RA MICA
14 t-cell leukemia 10.1
15 hepatosplenic t-cell lymphoma 10.1
16 hepatitis 10.0
17 heavy chain disease 10.0
18 gamma heavy chain disease 10.0
19 prolymphocytic leukemia 10.0
20 autoimmune hemolytic anemia 10.0
21 renal tubular acidosis 9.9 CSF2 IL2RA
22 myelodysplastic syndrome 9.9
23 felty syndrome 9.9
24 hematopoietic stem cell transplantation 9.9
25 hairy cell leukemia 9.9
26 purpura 9.9
27 chronic active epstein-barr virus infection 9.9
28 splenomegaly 9.9
29 t-cell prolymphocytic leukemia 9.9
30 orofaciodigital syndrome iv 9.9 IL2RA STAT3
31 acral lentiginous melanoma 9.9 CSF2 IL2RA
32 fallopian tube endometriosis 9.8 CSF2 IL2RA
33 epstein-barr virus, susceptibility to chronic infection by 9.8 IL2RA STAT3
34 18p deletion syndrome 9.8 CSF2 IL2RA
35 intracranial hemorrhage in brain cerebrovascular malformations 9.8 CSF2 STAT3
36 systemic lupus erythematosus 9.8
37 hepatitis c virus 9.8
38 hepatocellular carcinoma 9.8
39 bacteremia 9.8
40 aplastic anemia 9.8
41 celiac disease 9.8
42 anaplastic large cell lymphoma 9.8
43 autoimmune hepatitis 9.8
44 b-cell lymphomas 9.8
45 chronic lymphocytic leukemia 9.8
46 chronic myelomonocytic leukemia 9.8
47 common variable immunodeficiency 9.8
48 crohn's disease 9.8
49 granuloma annulare 9.8
50 lymphomatoid granulomatosis 9.8

Graphical network of the top 20 diseases related to Large Granular Lymphocyte Leukemia:



Diseases related to Large Granular Lymphocyte Leukemia

Symptoms & Phenotypes for Large Granular Lymphocyte Leukemia

GenomeRNAi Phenotypes related to Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.78 MICA
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.78 IL2RA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.78 MICA IL2RA KLRK1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.78 KLRK1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.78 KLRK1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.78 IL2RA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.78 IL2RA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.78 KLRK1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.78 KLRK1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.78 IL2RA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.78 IL2RA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.78 IL2RA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.78 MICA IL2RA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.78 IL2RA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.78 IL2RA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.78 KLRK1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.78 KLRK1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.78 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.78 MICA IL2RA
20 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.78 IL2RA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.78 IL2RA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.78 MICA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.78 IL2RA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.78 MICA
25 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.78 IL2RA

Drugs & Therapeutics for Large Granular Lymphocyte Leukemia

Drugs for Large Granular Lymphocyte Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 236)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefepime Approved Phase 3 88040-23-7 5479537
2
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
3
Ofloxacin Approved Phase 3 82419-36-1 4583
4
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
5
Carboplatin Approved Phase 2, Phase 3,Phase 1 41575-94-4 10339178 498142 38904
6
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
7
Darbepoetin alfa Approved, Investigational Phase 3,Phase 2 11096-26-7, 209810-58-2
8
Iron Approved Phase 3,Phase 1,Phase 2 7439-89-6 23925
9
Ondansetron Approved Phase 3 99614-02-5 4595
10
Dextromethorphan Approved Phase 3 125-71-3 5360696 5362449
11
Guaifenesin Approved, Vet_approved Phase 3,Phase 2 93-14-1 3516
12
Morphine Approved, Investigational Phase 3 57-27-2 5288826
13
Dalteparin Approved Phase 3 9005-49-6
14
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
15
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
16
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
17
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
18
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
19
Busulfan Approved, Investigational Phase 2, Phase 3,Early Phase 1 55-98-1 2478
20
Etoposide Approved Phase 2, Phase 3,Phase 1,Early Phase 1 33419-42-0 36462
21
Fludarabine Approved Phase 2, Phase 3, Phase 1 21679-14-1, 75607-67-9 30751
22 Thiotepa Approved Phase 2, Phase 3,Phase 1 52-24-4 5453
23
Melphalan Approved Phase 2, Phase 3 148-82-3 4053 460612
24
Ginseng Approved, Nutraceutical Phase 3 50647-08-0
25 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
26 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
27 Anti-Infective Agents Phase 3,Phase 2,Phase 1
28 Cephalosporins Phase 3
29 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
30 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 1,Phase 2
31 Renal Agents Phase 3,Phase 1,Phase 2
32 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
33 Analgesics Phase 3,Phase 2
34 Anesthetics Phase 3
35 Anesthetics, Dissociative Phase 3
36 Anesthetics, General Phase 3
37 Anesthetics, Intravenous Phase 3
38 Central Nervous System Depressants Phase 3,Phase 1,Phase 2
39 Excitatory Amino Acid Antagonists Phase 3
40 Excitatory Amino Acids Phase 3
41 Neurotransmitter Agents Phase 3,Phase 1
42 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
43 Alkylating Agents Phase 2, Phase 3,Phase 1,Early Phase 1
44 Antirheumatic Agents Phase 2, Phase 3,Phase 1,Early Phase 1
45 Immunosuppressive Agents Phase 2, Phase 3,Phase 1,Early Phase 1
46 Ferric Compounds Phase 3
47 ferric gluconate Phase 3
48 Hematinics Phase 3,Phase 2
49 Anti-Anxiety Agents Phase 3
50 Antiemetics Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 128)

id Name Status NCT ID Phase Drugs
1 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
2 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
3 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3 American ginseng
4 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
5 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
6 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
7 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
8 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
9 Darbepoetin Alfa Compared With Epoetin Alfa in Treating Anemia in Patients Receiving Chemotherapy for Cancer Completed NCT00070382 Phase 3 darbepoetin alfa;epoetin alfa
10 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3 Fragmin
11 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
12 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
13 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
14 Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer Active, not recruiting NCT00003816 Phase 2, Phase 3 busulfan;carboplatin;cyclophosphamide;etoposide;fludarabine phosphate;melphalan;thiotepa
15 Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas Unknown status NCT01805037 Phase 1, Phase 2 brentuximab vedotin
16 Dasatinib in Patients With Chronic Myeloid Leukemia in Chronic Phase Unknown status NCT01802450 Phase 2 Dasatinib
17 Cyclosporine in Treating Patients With Low Blood Counts Caused By Hematologic Cancer Completed NCT00031980 Phase 2 cyclosporine
18 506U78 in Treating Patients With Chronic Lymphocytic Leukemia That Has Not Responded to Fludarabine or Alkylating Agents Completed NCT00003635 Phase 2 nelarabine
19 Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Completed NCT01093586 Phase 2 busulfan;cyclophosphamide;anti-thymocyte globulin;methylprednisolone;cyclosporine;mycophenolate mofetil
20 Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma Completed NCT01258998 Phase 2 Akt inhibitor MK2206
21 Combination Chemotherapy Followed By Alemtuzumab in Treating Patients With Chronic Lymphocytic Leukemia or Prolymphocytic Leukemia Completed NCT00278213 Phase 2 cyclophosphamide;fludarabine phosphate;mitoxantrone hydrochloride
22 Peripheral Stem Cell Transplantation in Treating Patients With Breast Cancer or Hematologic Cancer Completed NCT00006225 Phase 1, Phase 2
23 Doxorubicin Hydrochloride Liposome and Bortezomib in Treating Patients With Refractory Hematologic Cancer or Malignant Solid Tumor or Metastatic Breast Cancer Completed NCT00237627 Phase 1, Phase 2 PS-341;Doxil;Velcade
24 Epoetin Alfa or Darbepoetin Alfa in Treating Patients With Anemia Caused by Chemotherapy Completed NCT00416624 Phase 2 darbepoetin alfa;epoetin alfa
25 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00005804 Phase 2 cyclophosphamide
26 Epoetin Alfa in Treating Patients With Anemia Who Are Undergoing Chemotherapy for Cancer Completed NCT00255749 Phase 2
27 Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Refractory Cancer Completed NCT00003406 Phase 1, Phase 2 carboplatin;docetaxel;ifosfamide
28 Donor Natural Killer Cells After Donor Stem Cell Transplant in Treating Patients With Advanced Cancer Completed NCT00823524 Phase 1, Phase 2
29 Interleukin-2 Plus Interferon Alfa in Treating Adults With Metastatic Cancer Completed NCT00002504 Phase 2
30 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2 caspofungin acetate
31 A Study of Complete Molecular Response for Chronic Myeloid Leukemia in Chronic Phase Patients, Treated With Dasatinib Completed NCT01342679 Phase 2 dasatinib
32 Prospective, Multicentric, Phase II Randomized Controlled Trial on Two Parallel Groups Comparing the Efficacy of Two Immunosuppressive Drugs (Methotrexate, Cyclophosphamide) in Large Granular Lymphocytes Leukemia Recruiting NCT01976182 Phase 2 Methotrexate;Cyclophosphamide
33 Dasatinib for Immune Modulation After Donor Stem Cell Transplant for Hematologic Malignancies Recruiting NCT01643603 Phase 1, Phase 2 Dasatinib
34 Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies Recruiting NCT01839916 Phase 2
35 Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies Recruiting NCT01760655 Phase 2 Fludarabine phosphate;Thiotepa;Cyclophosphamide;Tacrolimus;Mycophenolate mofetil
36 A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies Recruiting NCT01384513 Phase 2 Fludarabine;Busulfan;Cyclophosphamide (CY);Tacrolimus;Mycophenolate mofetil
37 Dasatinib for Modulating Immune System After Autologous Stem Cell Transplants for Multiple Myeloma, Non-Hodgkin, or Hodgkin Lymphoma Recruiting NCT01609816 Phase 1, Phase 2 Dasatinib
38 Biological Therapy in Treating Patients at High-Risk or With Lymphoma, Lymphoproliferative Disease, or Malignancies Recruiting NCT00002663 Phase 1, Phase 2
39 CAR-pNK Cell Immunotherapy in CD7 Positive Leukemia and Lymphoma Recruiting NCT02742727 Phase 1, Phase 2
40 Alemtuzumab (Campath ) to Treat T-Large Granular Lymphocyte Leukemia Active, not recruiting NCT00345345 Phase 2 Alemtuzumab (Campath)
41 Fludarabine Phosphate, Radiation Therapy, and Rituximab in Treating Patients Who Are Undergoing Donor Stem Cell Transplant Followed by Rituximab for High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Active, not recruiting NCT00104858 Phase 2 Cyclosporine;Fludarabine Phosphate;Mycophenolate Mofetil
42 Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer Active, not recruiting NCT00006251 Phase 1, Phase 2 fludarabine phosphate;cyclosporine;mycophenolate mofetil
43 Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant Active, not recruiting NCT00078858 Phase 1, Phase 2 fludarabine phosphate;cyclosporine;mycophenolate mofetil
44 Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Active, not recruiting NCT01529827 Phase 2 fludarabine phosphate;melphalan;tacrolimus;mycophenolate mofetil;methotrexate
45 Alemtuzumab, Fludarabine Phosphate, and Low-Dose Total Body Irradiation Before Donor Stem Cell Transplantation in Treating Patients With Hematological Malignancies Active, not recruiting NCT00040846 Phase 2 fludarabine phosphate;mycophenolate mofetil;cyclosporine
46 A Dose-Ranging Study of IV BNZ-1 in LGL Leukemia or Refractory CTCL Not yet recruiting NCT03239392 Phase 1, Phase 2 BNZ132-1-40
47 Effect of Cyclosporine Therapy on Gene Expression in Patients With Large Granular Lymphocyte Leukemia Terminated NCT00363779 Phase 2 Cyclosporine
48 Methotrexate Followed by Fludarabine in Patients With T-Cell Large Granular Lymphocytic Leukemia Terminated NCT00278265 Phase 2 MTX followed by fludarabine
49 Tipifarnib in Treating Patients With Anemia or Neutropenia and Large Granular Lymphocyte Leukemia Terminated NCT00360776 Phase 2 tipifarnib
50 Alemtuzumab in Myelodysplastic Syndrome (MDS), Aplastic Anemia, and T-Cell Large Granular Lymphocytic Leukemia (T-GL) Terminated NCT01191749 Phase 2 Alemtuzumab

Search NIH Clinical Center for Large Granular Lymphocyte Leukemia

Genetic Tests for Large Granular Lymphocyte Leukemia

Anatomical Context for Large Granular Lymphocyte Leukemia

MalaCards organs/tissues related to Large Granular Lymphocyte Leukemia:

39
T Cells, Bone, Bone Marrow, Spleen, Neutrophil, Myeloid, Liver

Publications for Large Granular Lymphocyte Leukemia

Articles related to Large Granular Lymphocyte Leukemia:

(show top 50) (show all 231)
id Title Authors Year
1
Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach. ( 28167832 )
2017
2
Distinguishing Between Hepatosplenic T-cell Lymphoma and I^I' T-cell Large Granular Lymphocytic Leukemia: A Clinicopathologic, Immunophenotypic, and Molecular Analysis. ( 27755009 )
2017
3
Dysregulated signaling, proliferation and apoptosis impact on the pathogenesis of TCRI^I'+ T cell large granular lymphocyte leukemia. ( 28407008 )
2017
4
Single-center Series of Bone Marrow Biopsy-Defined Large Granular Lymphocyte Leukemia: High Rates of Sustained Response to Oral Methotrexate. ( 27640075 )
2016
5
A population-based study of large granular lymphocyte leukemia. ( 27494824 )
2016
6
Donor-Derived T-Cell Large Granular Lymphocytic Leukemia in a Patient With Peripheral T-Cell Lymphoma. ( 27496109 )
2016
7
Population-based analyses among 184 patients diagnosed with large granular lymphocyte leukemia in the Netherlands between 2001 and 2013. ( 27055870 )
2016
8
Prolonged complete hematologic response in relapsed/refractory T-large granular lymphocyte leukemia after bendamustine treatment. ( 27896231 )
2016
9
AOHE: manuscript AOHE-D-16-00564 paroxysmal nocturnal hemoglobinuria with autoimmune hemolytic anemia following eculizumab therapy-with large granular lymphocytic leukemia. ( 27449072 )
2016
10
Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia. ( 26199174 )
2016
11
High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia. ( 27697773 )
2016
12
Gamma Heavy Chain Disease with T-cell Large Granular Lymphocytic Leukemia: A Case Report and Review of the Literature. ( 26875967 )
2016
13
Cell size variations of large granular lymphocyte leukemia: Implication of a small cell subtype of granular lymphocyte leukemia with STAT3 mutations. ( 27064362 )
2016
14
Moderate-dose cyclophosphamide in the treatment of relapsed/refractory T-cell large granular lymphocytic leukemia-associated pure red cell aplasia. ( 27077768 )
2016
15
The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia. ( 25281507 )
2015
16
Hematopoietic stem cell transplantation for T-cell large granular lymphocyte leukemia: a retrospective study of the European Society for Blood and Marrow Transplantation. ( 26460210 )
2015
17
Good syndrome presenting with CD8+ T-Cell large granular lymphocyte leukemia. ( 26429871 )
2015
18
Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia. ( 26252351 )
2015
19
Gamma heavy chain disease associated with large granular lymphocytic leukemia: A report of two cases and review of the literature. ( 26222587 )
2015
20
Hepatic Lesions Caused by Large Granular Lymphocyte Leukemia in Fischer 344 Rats: Similar Morphologic Features and Morphogenesis to Those of Nodular Regenerative Hyperplasia (NRH) in the Human Liver. ( 25903270 )
2015
21
T-Cell Large Granular Lymphocyte Leukemia in the Lower Eyelid. ( 25198396 )
2014
22
Lymphoma with features intermediate between aggressive T-large granular lymphocytic leukemia and hepatosplenic T-cell lymphoma: a diagnostic dilemma? ( 24524924 )
2014
23
Distinct effect of cyclophosphamide and cyclosporine on pure red cell aplasia associated with T-cell large granular lymphocyte leukemia. ( 25466263 )
2014
24
Acquired inhibitors to factor VIII and fibrinogen in the setting of T-cell large granular lymphocyte leukemia: a case report and review of the literature. ( 25396761 )
2014
25
Concurrent administration of darbepoetin alfa, cyclosporine A, and prednisolone is useful for T cell large granular lymphocyte leukemia associated with myelodysplastic syndrome complicated by Coombs-negative hemolytic anemia. ( 24756696 )
2014
26
Submicroscopic genomic rearrangements change gene expression in T-cell large granular lymphocyte leukemia. ( 24649974 )
2014
27
Lack of common TCRA and TCRB clonotypes in CD8(+)/TCRI+I^(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL. ( 24413066 )
2014
28
Coexistence of ALK-anaplastic large cell lymphoma and CD4+ T cell large granular lymphocytic leukemia. ( 25100004 )
2014
29
High rate of both hematopoietic and solid tumors associated with large granular lymphocyte leukemia. ( 24882263 )
2014
30
Uncovering the pathogenesis of large granular lymphocytic leukemia-novel STAT3 and STAT5b mutations. ( 24512550 )
2014
31
T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: Metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities. ( 25238936 )
2014
32
The pathogenesis and treatment of large granular lymphocyte leukemia. ( 24679833 )
2014
33
Large granular lymphocyte leukemia and lymphomatoid granulomatosis in the same patient: fortuitous association? ( 22799270 )
2013
34
CD4(-)/CD8(-) variant of T-cell large granular lymphocytic leukemia or hepatosplenic T-cell lymphoma: a clinicopathologic dilemma. ( 23800602 )
2013
35
Treatment of T-cell large granular lymphocyte leukemia with cyclosporine A: experience in a Chinese single institution. ( 23395383 )
2013
36
STAT3 mutations are highly specific for large granular lymphocytic leukemia. ( 23207521 )
2013
37
Unusual concurrence of T-cell large granular lymphocytic leukemia with Franklin disease (gamma heavy chain disease) manifested with massive splenomegaly. ( 22694793 )
2013
38
STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia. ( 24283217 )
2013
39
Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemia. ( 23515927 )
2013
40
Long-term remission of T-cell large granular lymphocyte leukemia associated with rheumatoid arthritis after rituximab therapy. ( 23869084 )
2013
41
Targeting IL-15 in large granular lymphocyte leukemia. ( 23634735 )
2013
42
Chronic active Epstein-Barr virus infection with progression to large granular lymphocytic leukemia. ( 23731478 )
2013
43
Deep sequencing of the T-cell receptor repertoire in CD8+ T-large granular lymphocyte leukemia identifies signature landscapes. ( 24149287 )
2013
44
Diagnosing large granular lymphocyte leukemia is bloody difficult. ( 23025294 )
2013
45
Familial CD3+ T Large Granular Lymphocyte Leukemia: Evidence that Genetic Predisposition and Antigen Selection Promote Clonal Cytotoxic T-Cell Responses. ( 24180333 )
2013
46
Does IL-15 have a causative role in large granular lymphocyte leukemia? ( 23444952 )
2013
47
T-cell large granular lymphocyte leukemia in a child with anemia and Crohn's disease. ( 23409990 )
2013
48
Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation. ( 24317090 )
2013
49
Diagnosis of large granular lymphocytic leukemia in a patient previously treated for acute myeloblastic leukemia. ( 24416499 )
2013
50
STAT3 gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia. ( 24350896 )
2013

Variations for Large Granular Lymphocyte Leukemia

Expression for Large Granular Lymphocyte Leukemia

Search GEO for disease gene expression data for Large Granular Lymphocyte Leukemia.

Pathways for Large Granular Lymphocyte Leukemia

Pathways related to Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 CSF2 IL2RA KLRK1 MICA STAT3
2
Show member pathways
12.02 CSF2 KLRK1 MICA
3 11.71 KLRK1 MICA
4
Show member pathways
11.69 IL2RA STAT3
5
Show member pathways
11.65 IL2RA STAT3
6
Show member pathways
11.6 IL2RA STAT3
7
Show member pathways
11.57 CSF2 IL2RA STAT3
8 11.53 IL2RA STAT3
9 11.52 CSF2 IL2RA
10
Show member pathways
11.49 CSF2 STAT3
11 11.4 IL2RA KLRK1
12
Show member pathways
11.36 CSF2 IL2RA
13 11.15 CSF2 STAT3
14
Show member pathways
11.08 IL2RA STAT3
15
Show member pathways
11.01 CSF2 IL2RA
16 10.87 CSF2 IL2RA KLRK1
17 10.77 IL2RA STAT3
18
Show member pathways
10.72 IL2RA STAT3
19 10.07 CSF2 STAT3

GO Terms for Large Granular Lymphocyte Leukemia

Cellular components related to Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.8 IL2RA KLRK1 MICA

Biological processes related to Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.16 CSF2 KLRK1
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 8.65 CSF2
3 natural killer cell mediated cytotoxicity GO:0042267 8.32 MICA

Molecular functions related to Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.62 CSF2 IL2RA

Sources for Large Granular Lymphocyte Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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