MCID: LRG008
MIFTS: 46

Large Granular Lymphocyte Leukemia malady

Immune category

Summaries for Large Granular Lymphocyte Leukemia

Sources:
43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Large granular lymphocyte (lgl) leukemia is a rare cancer of a type of white blood cells called lymphocytes. lgl leukemia causes a slow increase in white blood cells called t lymphocytes, or t cells, which originate in the lymph system and bone marrow and help to fight infection. this disease usually affects people in their sixties. symptoms include anemia; low levels of platelets (thrombocytopenia) and infection-fighting neutrophils (neutropenia) in the blood; and an enlarged spleen. about one-third of patients are asymptomatic at the time of diagnosis. the exact cause of lgl leukemia is unknown. doctors can diagnose this disease through a bone marrow biopsy, or by using a specialized technique in which various types of blood or bone marrow cells are separated, identified, and counted. last updated: 8/2/2011

MalaCards: Large Granular Lymphocyte Leukemia, also known as t-cell large granular lymphocyte leukemia, is related to arthritis and hepatitis c. An important gene associated with Large Granular Lymphocyte Leukemia is KIR2DL1 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1), and among its related pathways are Malaria and Legionellosis. The compounds pentoxifylline and pge2 have been mentioned in the context of this disorder. Affiliated tissues include skin, spleen and bone marrow, and related mouse phenotypes are skeleton and hematopoietic system.

Aliases & Classifications for Large Granular Lymphocyte Leukemia

Sources:
43NIH Rare Diseases, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

large granular lymphocyte leukemia 43
t-cell large granular lymphocyte leukemia 43 61
leukemia, large granular lymphocytic 61
lgl leukemia 43


Related Diseases for Large Granular Lymphocyte Leukemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Large Granular Lymphocyte Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 182)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.0TNF, IL8, IL6
2hepatitis c30.6TNF, IL18, IL10
3sjogren's syndrome30.4IL2RA
4celiac disease30.4IL15
5ulcerative colitis30.4TNF
6thrombocytopenia30.4IL6
7graft versus host disease30.4IL18, TNF, IL2RA, IL10, IL15
8systemic lupus erythematosus30.4IL18, IL2RA, IL6, IL10, IL15, LBR
9vasculitis30.2TNF
10behcet's disease30.2IL2RA, TNF, KIR2DL1, LBR, IL18, IL8
11t-cell large granular lymphocyte leukemia11.1
12t-cell leukemia11.0
13natural killer cell leukemia10.7
14acute leukemia10.6
15leukemia/lymphoma, t-cell10.6
16felty's syndrome10.5
17autoimmune hemolytic anemia10.4
18n syndrome10.4
19hepatitis a10.4
20chronic active epstein-barr virus infection10.4
21plasma cell leukemia10.4
22splenomegaly10.4
23autoimmune thrombocytopenic purpura10.3
24lambert-eaton myasthenic syndrome10.3
25acquired thrombocytopenia10.3
26common variable immunodeficiency10.3
27gamma heavy chain disease10.3
28granular cell tumor10.3
29protein-losing enteropathy10.3
30autoimmune hepatitis10.3
31malignant histiocytosis10.3
32granuloma annulare10.3
33acute lymphocytic leukemia10.3
34aplastic anemia10.3
35char syndrome10.3
36thrombocytopenia, acquired amegakaryocytic10.3
37lambert syndrome10.3
38leukemia, b-cell, chronic10.3
39chronic graft versus host disease10.3
40chronic myelomonocytic leukemia10.3
41leukemia, t-cell, chronic10.3
42essential thrombocythemia10.3
43lymphomatoid granulomatosis10.3
44bacteremia10.3
45hepatitis c virus10.3
46b-cell chronic lymphocytic leukemia10.3
47hematopoietic stem cell transplantation10.3
48t-cell prolymphocytic leukemia10.3
49hemoglobinuria10.1
50thymoma10.1

Graphical network of the top 20 diseases related to Large Granular Lymphocyte Leukemia:



Diseases related to large granular lymphocyte leukemia

Clinical Features for Large Granular Lymphocyte Leukemia

Drugs & Therapeutics for Large Granular Lymphocyte Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Large Granular Lymphocyte Leukemia

Drug clinical trials:

Search ClinicalTrials for Large Granular Lymphocyte Leukemia

Search NIH Clinical Center for Large Granular Lymphocyte Leukemia

Search CenterWatch for Large Granular Lymphocyte Leukemia

Genetic Tests for Large Granular Lymphocyte Leukemia

Anatomical Context for Large Granular Lymphocyte Leukemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Large Granular Lymphocyte Leukemia:

33
Skin, Spleen, Bone marrow, Whole blood, Nk cells, T cells, B cells

Animal Models for Large Granular Lymphocyte Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Large Granular Lymphocyte Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.9IL6, DUSP2, HCST, TYROBP
2MP:00053978.9LBR, HCST, TYROBP, IL2RA, SPHK1, IL15RA
3MP:00053848.8SPHK1, IL6, IL18, IL10, IL15RA, IL15
4MP:00053878.7HCST, LBR, SPHK1, IL6, IL8, IL18

Publications for Large Granular Lymphocyte Leukemia

Sources:
51PubMed
See all sources

Articles related to Large Granular Lymphocyte Leukemia:

(show top 50)    (show all 178)
idTitleAuthorsYear
1
Deep sequencing of the T-cell receptor repertoire in CD8+ T-large granular lymphocyte leukemia identifies signature landscapes. (24149287)
2013
2
Diagnosing large granular lymphocyte leukemia is bloody difficult. (23025294)
2013
3
Peripheral blood immunophenotypic analysis as a diagnostic tool for large granular lymphocyte leukemia. (22938095)
2013
4
Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation. (23153537)
2012
5
Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets. (22830400)
2012
6
Dynamical and structural analysis of a T cell survival network identifies novel candidate therapeutic targets for large granular lymphocyte leukemia. (22102804)
2011
7
Imatinib mesylate in T-cell large granular lymphocyte leukemia associated with chronic graft-versus-host disease. (21663506)
2011
8
A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia. (19660811)
2010
9
T/NK large granular lymphocyte leukemia and coexisting monoclonal B-cell lymphocytosis-like proliferations. An unrecognized and frequent association. (20472852)
2010
10
Lessons learned from an unusual presentation of CD3+, CD56- T-cell large granular lymphocyte leukemia. (20679608)
2010
11
Diagnosis and therapy of neutropenia in large granular lymphocyte leukemia. (19057202)
2009
12
T-cell large granular lymphocyte leukemia associated with myelodysplastic syndrome: a clinicopathologic study of nine cases. (19228641)
2009
13
T-cell large granular lymphocyte leukemia presenting as end-stage renal disease: the diagnostic role of flow-cytometric and clonality analysis of the urine sediment. (19203516)
2009
14
T cell large granular lymphocyte (LGL) leukemia associated with Behcet's disease: high expression of sFasL and IL-18 of CD8 LGL. (18236044)
2008
15
Outcomes of splenectomy in T-cell large granular lymphocyte leukemia with splenomegaly and cytopenia. (18550263)
2008
16
Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling. (18791165)
2008
17
Large granular lymphocyte leukemia after renal transplantation: an immunologic, immunohistochemical, and genotypic study. (17220805)
2007
18
Malignant transformation of T-cell large granular lymphocyte leukemia in a dog. (17611371)
2007
19
T-cell large granular lymphocyte leukemia of donor origin after cord blood transplantation. (17875238)
2007
20
Fludarabine, mitoxantrone and dexamethasone as first-line treatment for T-cell large granular lymphocyte leukemia. (17525720)
2007
21
Histopathology of the spleen in T-cell large granular lymphocyte leukemia and T-cell prolymphocytic leukemia: a comparative review. (15958859)
2005
22
T-cell large granular lymphocyte leukemias have multiple phenotypic abnormalities involving pan-T-cell antigens and receptors for MHC molecules. (16416744)
2005
23
CD52 expression in T-cell large granular lymphocyte leukemia--implications for treatment with alemtuzumab. (16019510)
2005
24
Allogeneic hematopoietic stem cell transplantation in a patient affected by large granular lymphocyte leukemia and multiple sclerosis. (14648027)
2004
25
T-cell large granular lymphocyte leukemia of donor origin after allogeneic bone marrow transplantation. (14560574)
2003
26
2-deoxycoformycin in the treatment of T-large granular lymphocyte leukemia. (12804646)
2003
27
SjAPgren's syndrome associated T cell large granular lymphocyte leukemia: a possible common etiopathogenesis. (12180753)
2002
28
Large granular lymphocyte leukemia: case report of chronic neutropenia and rheumatoid arthritis-like symptoms in a child. (11200497)
2001
29
Pure red cell aplasia associated with parvovirus B19 infection in T-large granular lymphocyte leukemia. (11911433)
2001
30
Pure red cell aplasia (PRCA) with thymoma: a possible distinct clinical entity distinct from large granular lymphocyte (LGL) leukemia. (10629578)
2000
31
Improvement of extrathymic T cell type of large granular lymphocyte (LGL) leukemia by cyclosporin A: the serum level of Fas ligand is a marker of LGL leukemia activity. (11073168)
2000
32
Current concepts: large granular lymphocyte leukemia. (10741898)
1999
33
Large granular lymphocyte leukemia/lymphoma in six cats. (9754542)
1998
34
Humoral immune abnormalities in T-cell large granular lymphocyte leukemia. (9031118)
1996
35
Epstein-Barr virus-associated CD3- large granular lymphocyte leukemia presenting with polycranial nerve palsies. (8639870)
1996
36
Response: pure red blood cell aplasia: association with large granular lymphocyte leukemia and the prognostic value of cytogenetic abnormalities. (8874229)
1996
37
Large granular lymphocyte leukemia]. (8937181)
1996
38
Severe neutropenia in T-large granular lymphocyte leukemia corrected by intensive immunosuppression. (8841105)
1996
39
Pure red cell aplasia: association with large granular lymphocyte leukemia and the prognostic value of cytogenetic abnormalities. (8639922)
1996
40
Resolution of autoimmune hemolytic anemia following splenectomy in CD3+ large granular lymphocyte leukemia. (9031124)
1996
41
Cytokine profile in acute myelofibrosis associated with aggressive large granular lymphocyte leukemia. (7639282)
1995
42
Proliferating cell nuclear antigen staining of Fischer-344/N rat spleens affected by large granular lymphocyte leukemia. (7770695)
1995
43
CD3+, CD56+ large granular lymphocyte leukemia. (7540072)
1995
44
CD3+, CD56+ aggressive variant of large granular lymphocyte leukemia. (7522625)
1994
45
Establishment and characterization of the T-cell line, EBT-8 latently infected with Epstein-Barr virus from large granular lymphocyte leukemia. (8057683)
1994
46
Detection of human T-cell leukemia/lymphoma virus, type II, in a patient with large granular lymphocyte leukemia. (1355373)
1992
47
Effects of large granular lymphocyte leukemia on bone in F344 rats. (2278127)
1990
48
Serial syngeneic transplantation of large granular lymphocyte leukemia in F344 rats. (2278128)
1990
49
Bone marrow involvement in large granular lymphocyte leukemia. (2318487)
1990
50
Hairy cell leukemia associated with large granular lymphocyte leukemia: immunologic and genomic study, effect of interferon treatment. (2840988)
1988

Genetic Variations for Large Granular Lymphocyte Leukemia

Expression for genes affiliated with Large Granular Lymphocyte Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Large Granular Lymphocyte Leukemia

Search GEO for disease gene expression data for Large Granular Lymphocyte Leukemia.

Pathways for genes affiliated with Large Granular Lymphocyte Leukemia

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore, 54Reactome, 53R&D Systems
See all sources

Pathways related to Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IL18
210.4IL8
3
Hide members
10.3IL15RA
4
Hide members
10.2IL2RA, IL15RA
510.2IL15, IL18
610.1IL6, IL8, IL18
710.1IL2RA, IL6, IL8
8
Hide members
10.1IL8, IL2RA, TNF
910.1TNF, IL2RA, IL6
10
Immune response Bacterial infections in normal airways
10.1TNF, IL6, IL8
1110.1IL8, IL6, TNF
1210.1IL6, TNF, IL10
13
Hide members
10.1IL15, IL18, IL15RA
14
Hide members
10.1IL15RA, IL15, IL2RA
15
Hide members
10.1IL15, IL2RA, IL15RA
16
Hide members
10.0TNF, IL18, IL6, IL8
17
Hide members
10.0IL18, IL6, IL8, TNF
18
Hide members
10.0IL6, IL18, IL10, TNF
19
Development PDGF signaling via STATs and NF-kB
Hide members
10.0IL18, IL10, TNF, IL6
20
Hide members
10.0TNF, IL6, IL18, IL10
2110.0IL18, TNF, IL6, IL10
22
Hide members
10.0IL8, TNF, IL6, IL10
2310.0IL8, IL10, TNF, IL6
2410.0IL8, IL10, IL6, TNF
2510.0TNF, IL10, IL8, IL6
26
Hide members
10.0KIR2DL1, TYROBP, KIR2DL3, HCST
279.9IL6, IL2RA, IL10, IL15, IL15RA
28
Hide members
9.9IL15RA, IL10, IL2RA, TNF, IL15
29
Hide members
9.9IL6, TNF, IL2RA, IL15RA, IL15
309.9IL15, IL15RA, TNF, IL2RA, IL6
319.9SPHK1, IL6, IL18, IL10, TNF
32
Hide members
9.8IL15, IL8, IL6, IL18, TNF, IL2RA
339.8IL6, IL15, IL10, IL18, IL8, TNF
34
Hide members
9.8KLRD1, IL6, IL2RA, TYROBP, HCST, IL18
35
Hide members
9.6KIR2DL3, KIR2DL1, HCST, TNF, SPHK1, KLRD1
36
Hide members
9.5TNF, IL2RA, IL6, IL8, IL18, IL10
37
Hide members
9.5IL18, IL6, IL2RA, IL10, IL15RA, IL15

Compounds for genes affiliated with Large Granular Lymphocyte Leukemia

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 2BitterDB, 60Tocris Bioscience, 50PharmGKB, 24HMDB
See all sources

Compounds related to Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1pentoxifylline45 1111.7LBR, IL18
2pge24510.7SPHK1
3gm-csf45 2911.7IL10, TNF
4prednisolone45 29 1112.6IL2RA
5hydrocortisone45 2 60 1113.6IL8
6cyclosporin a45 29 6012.5LBR, IL15, IL2RA
7cycloheximide4510.5IL18
8dexamethasone45 50 29 1113.4IL6, IL15, LBR
9cdp5714510.4IL6, IL10, TNF
102,5-oligoadenylate4510.4IL2RA, TNF
11natalizumab45 1111.4IL10, IL2RA, IL18, TNF
12mip 1alpha4510.4IL6, TNF, IL10, IL8
135 aminosalicylic acid4510.4TNF, IL8, IL10, IL2RA
14toxin-14510.4KLRD1, TNF, IL10, IL8
15con a4510.4LBR, IL2RA, IL10, IL18
16polymyxin b4510.4TNF, IL10, IL6, IL8
17tuberculin4510.3IL18, IL2RA, LBR, IL15, IL10
18rantes4510.3TNF, LBR, IL15, IL6, IL2RA
19imiquimod45 29 60 1113.3IL6, IL18, IL10, TNF, IL8
20groalpha4510.3IL10, IL18, IL8, IL6, TNF
21lipoteichoic acid4510.3IL10, IL18, IL8, IL6, TNF
22poly(i-c)4510.3IL6, IL8, IL18, TNF, IL15
23thalidomide45 50 60 1113.3IL2RA, IL10, IL18, IL6, TNF
248-isoprostane4510.3IL10, IL8, TNF, IL6
25peptidoglycan45 2911.3TNF, IL15, IL6, IL8, IL10
26chloroquine45 2 50 29 1114.2IL18, TNF, IL2RA, IL15, IL10
27il-124510.2IL6, IL8, IL18, IL10, IL15, TNF
28okt34510.2IL2RA, LBR, TNF, IL15, IL10, IL6
29polyinosinic-polycytidylic acid4510.2IL18, TNF, IL15, IL8, IL10, IL6
30etanercept45 50 1112.2IL10, IL18, IL15, IL6, TNF, IL8
31atorvastatin45 50 29 11 2414.2IL10, IL6, IL18, IL2RA, TNF
32ccl345 2911.2IL10, IL18, IL8, TNF, IL15, IL6
33gluten4510.2IL18, IL2RA
34ionomycin4510.2IL15, TNF, IL2RA, IL18, LBR, IL10
35neopterin4510.2IL6, TNF, LBR, IL2RA, IL10, IL18
36rituximab45 50 1112.1IL2RA, IL15, TNF, IL10, IL6, CD52
37infliximab45 50 1112.1IL15, IL2RA, IL10, LBR, IL18, TNF
38methotrexate45 50 1112.1TNF, IL18, IL6, IL10, IL15, IL2RA
39il 104510.1IL6, IL8, TNF, IL2RA, IL15, IL18
40tarc4510.0TNF, IL8, IL18, IL10
41n acetylcysteine4510.0IL2RA, IL18, IL8, IL6, SPHK1, TNF
42tgf beta14510.0IL18, IL10, TNF, IL15, IL6
43histamine45 29 2412.0IL18, IL15, IL2RA, TNF, IL8, IL10
44thymidine45 2411.0TNF, IL2RA, IL15, LBR, IL6, IL18
45simvastatin45 50 60 29 11 2414.9IL18, IL6, IL8, IL10, TNF
46rapamycin459.8SPHK1, IL18, IL10, IL15, IL2RA, LBR
47vegf459.8SPHK1, IL6, IL8, IL10, IL18, IL2RA
48nitric oxide45 11 2411.7IL10, IL18, IL15, LBR, FAM215A, IL8
49ly294002459.4IL6, IL8, IL18, IL10, TNF, SPHK1
50tyrosine459.4IL15, KLRD1, IL2RA, IL6, SPHK1, KIR2DL1

GO Terms for genes affiliated with Large Granular Lymphocyte Leukemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.0IL6, IL2RA, TNF, KLRD1
2extracellular spaceGO:0056159.5IL6, TNF, IL15, IL15RA, IL10, IL18
3integral to plasma membraneGO:0058879.3TNF, TYROBP, CD52, IL15, SIGLEC7, KIR2DL3

Biological processes related to Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cytokine secretion involved in immune responseGO:00274010.6IL10
2receptor biosynthetic processGO:03280010.5IL10, TNF
3type 2 immune responseGO:04209210.5IL18, IL10
4positive regulation of tissue remodelingGO:03410510.4IL15, IL18
5positive regulation of chemokine productionGO:03272210.4IL6, IL18, TNF
6positive regulation of natural killer cell proliferationGO:03281910.4IL15, IL18
7negative regulation of lipid storageGO:01088810.4IL6, TNF
8positive regulation of NF-kappaB import into nucleusGO:04234610.4TNF, IL18, SPHK1
9epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.4IL6, TNF
10calcium-mediated signalingGO:01972210.3TNF, IL8, SPHK1
11response to molecule of bacterial originGO:00223710.3IL8, IL10
12positive regulation of interleukin-17 productionGO:03274010.2IL18, IL15
13regulation of immune responseGO:05077610.2KLRD1, HCST, TYROBP, KIR2DL3, KIR2DL1
14response to glucocorticoid stimulusGO:05138410.2TNF, IL10, IL6
15immune responseGO:00695510.1IL2RA, IL15, IL18, IL8, KIR2DL3, KIR2DL1
16positive regulation of natural killer cell differentiationGO:03282510.1IL15RA, IL15
17inflammatory responseGO:0069549.9SPHK1, IL6, IL8, IL18, IL10, IL15
18positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.8TNF, IL10, IL6

Molecular functions related to Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.9IL6, IL18, IL10, IL15, TNF

Products for genes affiliated with Large Granular Lymphocyte Leukemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Large Granular Lymphocyte Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet