MCID: LRG008
MIFTS: 39

Large Granular Lymphocyte Leukemia malady

Rare diseases, Immune diseases categories

Summaries for Large Granular Lymphocyte Leukemia

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44NIH Rare Diseases, 34MalaCards
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NIH Rare Diseases:44 Large granular lymphocyte (lgl) leukemia is a rareĀ cancer of a type of white blood cells called lymphocytes. lgl leukemia causes a slow increase in white blood cells called t lymphocytes, or t cells, which originate in the lymph system and bone marrow and help to fight infection.Ā this disease usually affects people in their sixties. symptoms include anemia; low levels of platelets (thrombocytopenia)Ā and infection-fighting neutrophils (neutropenia) in the blood; and an enlarged spleen. about one-third of patients are asymptomatic at the time of diagnosis. the exact cause of lgl leukemia is unknown. doctors can diagnose this disease through a bone marrow biopsy, or byĀ using a specialized techniqueĀ in which various types of blood or bone marrow cells are separated, identified, and counted. last updated: 8/2/2011

MalaCards: Large Granular Lymphocyte Leukemia, also known as t-cell large granular lymphocyte leukemia, is related to leukemia and rheumatoid arthritis. An important gene associated with Large Granular Lymphocyte Leukemia is KIR2DL1 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1), and among its related pathways are Class I MHC mediated antigen processing and presentation and Signaling by FGFR. The compounds tuberculin and cuprophan have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow.

Aliases & Classifications for Large Granular Lymphocyte Leukemia

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44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Immune diseases


Aliases & Descriptions:

large granular lymphocyte leukemia 44
t-cell large granular lymphocyte leukemia 44 63
leukemia, large granular lymphocytic 63
lgl leukemia 44


Related Diseases for Large Granular Lymphocyte Leukemia

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Large Granular Lymphocyte Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.0IL2RA, LBR, KLRK1
2rheumatoid arthritis31.0LBR, KLRK1, KIR2DL1, IL2RA
3t-cell leukemia30.7LBR, IL2RA
4celiac disease30.4KLRK1, MICA
5systemic lupus erythematosus30.4IL2RA, KLRK1, LBR
6multiple sclerosis30.4IL2RA, LBR, KLRK1
7behcet's disease30.2KIR2DL1, LBR, IL2RA
8t-cell large granular lymphocyte leukemia11.2
9pure red-cell aplasia10.8
10arthritis10.7
11neutropenia10.7
12natural killer cell leukemia10.6
13hemolytic anemia10.5
14autoimmune hemolytic anemia10.4
15hairy cell leukemia10.4
16hepatitis10.4
17myeloma10.4
18prolymphocytic leukemia10.4
19purpura10.4
20chronic active epstein-barr virus infection10.4
21splenomegaly10.4
22hepatosplenic t-cell lymphoma10.4
23graft versus host disease10.3
24crohn's disease10.3
25hepatitis c10.3
26gamma heavy chain disease10.3
27protein-losing enteropathy10.3
28autoimmune hepatitis10.3
29ulcerative colitis10.3
30malignant histiocytosis10.3
31lambert-eaton myasthenic syndrome10.3
32sjogren's syndrome10.3
33common variable immunodeficiency10.3
34felty's syndrome10.3
35granuloma annulare10.3
36aplastic anemia10.3
37candidiasis10.3
38chronic lymphocytic leukemia10.3
39encephalitis10.3
40heavy chain disease10.3
41hepatocellular carcinoma10.3
42histiocytosis10.3
43lupus erythematosus10.3
44myelofibrosis10.3
45neuropathy10.3
46thrombocytopenia10.3
47b-cell lymphomas10.3
48chronic graft versus host disease10.3
49chronic myelomonocytic leukemia10.3
50essential thrombocythemia10.3

Graphical network of the top 20 diseases related to Large Granular Lymphocyte Leukemia:



Diseases related to large granular lymphocyte leukemia

Symptoms for Large Granular Lymphocyte Leukemia

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Drugs & Therapeutics for Large Granular Lymphocyte Leukemia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Large Granular Lymphocyte Leukemia

Drug clinical trials:

Search ClinicalTrials for Large Granular Lymphocyte Leukemia

Search NIH Clinical Center for Large Granular Lymphocyte Leukemia

Search CenterWatch for Large Granular Lymphocyte Leukemia

Genetic Tests for Large Granular Lymphocyte Leukemia

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Anatomical Context for Large Granular Lymphocyte Leukemia

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34MalaCards
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MalaCards organs/tissues related to Large Granular Lymphocyte Leukemia:

34
T cells, Bone, Bone marrow, Spleen, Nk cells, B cells, Skin

Animal Models for Large Granular Lymphocyte Leukemia or affiliated genes

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Publications for Large Granular Lymphocyte Leukemia

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53PubMed
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Articles related to Large Granular Lymphocyte Leukemia:

(show top 50)    (show all 195)
idTitleAuthorsYear
1
Lack of common TCRA and TCRB clonotypes in CD8(+)/TCRI+I^(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL. (24413066)
2014
2
Chronic active Epstein-Barr virus infection with progression to large granular lymphocytic leukemia. (23731478)
2013
3
Large granular lymphocyte leukemia and lymphomatoid granulomatosis in the same patient: fortuitous association? (22799270)
2013
4
Large granular lymphocytic leukemia associated with Lambert-Eaton Myasthenic Syndrome: A case report. (24371773)
2013
5
Treatment of T-cell large granular lymphocyte leukemia with cyclosporine A: experience in a Chinese single institution. (23395383)
2013
6
STAT3 mutations are highly specific for large granular lymphocytic leukemia. (23207521)
2013
7
Targeting IL-15 in large granular lymphocyte leukemia. (23634735)
2013
8
Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemia. (23515927)
2013
9
Deep sequencing of the T-cell receptor repertoire in CD8+ T-large granular lymphocyte leukemia identifies signature landscapes. (24149287)
2013
10
Diagnosing large granular lymphocyte leukemia is bloody difficult. (23025294)
2013
11
Fibrosis and subsequent cytopenias are associated with basic fibroblast growth factor-deficient pluripotent mesenchymal stromal cells in large granular lymphocyte leukemia. (24014875)
2013
12
Large granular lymphocytic leukemia: a treatable form of refractory celiac disease. (22922421)
2012
13
Autoimmune manifestations in large granular lymphocyte leukemia. (22999943)
2012
14
Extracorporeal photopheresis as a curative treatment strategy in non epidermotropic T-cell lymphoma and large granular lymphocyte leukemia. (22422944)
2012
15
Lymphocytosis: T-cell large granular lymphocyte leukemia. (23082329)
2012
16
Dynamical and structural analysis of a T cell survival network identifies novel candidate therapeutic targets for large granular lymphocyte leukemia. (22102804)
2011
17
Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia. (21865345)
2011
18
Long-term safety and efficacy of cyclosporin A therapy for T-cell large granular lymphocyte leukemia. (20038217)
2010
19
A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia. (19660811)
2010
20
T/NK large granular lymphocyte leukemia and coexisting monoclonal B-cell lymphocytosis-like proliferations. An unrecognized and frequent association. (20472852)
2010
21
Diagnosis and therapy of neutropenia in large granular lymphocyte leukemia. (19057202)
2009
22
Interleukin-15 enhances proteasomal degradation of bid in normal lymphocytes: implications for large granular lymphocyte leukemias. (19366803)
2009
23
Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia associated with an occult large granular lymphocyte leukemia. (17915315)
2008
24
Large granular lymphocyte leukemia after renal transplantation: an immunologic, immunohistochemical, and genotypic study. (17220805)
2007
25
T-gamma delta large granular lymphocyte leukemia preceded by pure red cell aplasia and complicated with hemophagocytic syndrome caused by Epstein-Barr virus infection. (16755095)
2006
26
Pathogenesis of neutropenia in large granular lymphocyte leukemia and Felty syndrome. (16530306)
2006
27
Large granular lymphocyte leukemia. (16549811)
2006
28
Histopathology of the spleen in T-cell large granular lymphocyte leukemia and T-cell prolymphocytic leukemia: a comparative review. (15958859)
2005
29
T-cell large granular lymphocyte leukemias have multiple phenotypic abnormalities involving pan-T-cell antigens and receptors for MHC molecules. (16416744)
2005
30
Reversible paraneoplastic neuropathy associated with T-cell large granular lymphocyte leukemia. (15304606)
2004
31
T-gamma large granular lymphocyte leukemia associated with amegakaryocytic thrombocytopenic purpura, SjAPgren's syndrome, and polyglandular autoimmune syndrome type II, with subsequent development of pure red cell aplasia. (11835350)
2002
32
Deletion 6q as a recurrent chromosomal aberration in T-cell large granular lymphocyte leukemia. (12547164)
2002
33
Pathologic quiz case: chronic anemia with red cell aplasia and lymphocytosis in a middle-aged man. T-cell large granular lymphocyte leukemia. (12503585)
2002
34
Large granular lymphocyte leukemia: case report of chronic neutropenia and rheumatoid arthritis-like symptoms in a child. (11200497)
2001
35
Aggressive variant of morphologically typical T large granular lymphocyte leukemia/lymphoma lacking NK cell markers. (11154985)
2000
36
Large granular lymphocyte leukemia/lymphoma in six cats. (9754542)
1998
37
Induction of clinical remission in T-large granular lymphocyte leukemia with cyclosporin A, monitored by use of immunophenotyping with Vbeta antibodies. (9519776)
1998
38
Cytokine expression and tumorigenicity of large granular lymphocytic leukemia cells from mice transgenic for the tax gene of human T-cell leukemia virus type I. (9226179)
1997
39
Humoral immune abnormalities in T-cell large granular lymphocyte leukemia. (9031118)
1996
40
Epstein-Barr virus-associated CD3- large granular lymphocyte leukemia presenting with polycranial nerve palsies. (8639870)
1996
41
Pure red blood cell aplasia associated with parvovirus B19 infection in large granular lymphocyte leukemia. (8605376)
1996
42
Clostridium septicum bacteremia in a patient with large granular lymphocyte leukemia. (7552816)
1995
43
Epstein-Barr virus-associated large granular lymphocyte leukemia with cutaneous infiltration. (8040410)
1994
44
Epstein-Barr virus-associated natural killer-large granular lymphocyte leukemia. (8088773)
1994
45
Failure to detect Epstein-Barr virus DNA in peripheral blood mononuclear cells of most patients with large granular lymphocyte leukemia. (8387836)
1993
46
Transplantation of large granular lymphocyte leukemia in congenitally athymic rats. (1621333)
1992
47
Effects of large granular lymphocyte leukemia on bone in F344 rats. (2278127)
1990
48
Rearrangement and expression of T-cell receptor genes in large granular lymphocyte leukemia. (3345349)
1988
49
Large granular lymphocyte leukemia. Report of 38 cases and review of the literature. (3626848)
1987
50
Large granular lymphocyte leukemia. A heterogeneous lymphocytic leukemia in F344 rats. (6837719)
1983

Variations for Large Granular Lymphocyte Leukemia

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Expression for genes affiliated with Large Granular Lymphocyte Leukemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Large Granular Lymphocyte Leukemia

Search GEO for disease gene expression data for Large Granular Lymphocyte Leukemia.

Pathways for genes affiliated with Large Granular Lymphocyte Leukemia

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51PathCards, 56Reactome, 31KEGG, 61Thomson Reuters, 39NCBI BioSystems Database, 54QIAGEN
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Compounds for genes affiliated with Large Granular Lymphocyte Leukemia

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46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1tuberculin469.7IL2RA, LBR
2cuprophan469.7IL2RA, LBR
3phorbol 12,13-dibutyrate469.7LBR, IL2RA
4okt3469.7IL2RA, LBR
5con a469.6IL2RA, LBR
6diethyl dithiocarbamate469.6LBR, IL2RA
7sodium arsenite469.6IL2RA, LBR
8ouabain46 1210.6IL2RA, LBR
9infliximab46 52 1211.6LBR, IL2RA
10pentoxifylline46 1210.6IL2RA, LBR
11neopterin469.6LBR, IL2RA
12malondialdehyde469.5LBR, IL2RA
13cadmium46 2510.5IL2RA, LBR
14melatonin46 30 62 25 1213.5IL2RA, LBR
15vitamin-e469.4LBR, IL2RA
16mifepristone46 30 62 1212.4IL2RA, LBR
17rantes469.3IL2RA, LBR
18nifedipine46 30 52 1212.2LBR, IL2RA
19ionomycin469.0IL2RA, LBR
20arginine468.8KLRK1, IL2RA, LBR
21tyrosine468.7LBR, IL2RA, KIR2DL3, KIR2DL1

GO Terms for genes affiliated with Large Granular Lymphocyte Leukemia

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17Gene Ontology
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Cellular components related to Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.8KIR2DL1, KIR2DL3, MICA

Biological processes related to Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:0507769.6KIR2DL1, KIR2DL3
2immune responseGO:0069558.8KIR2DL1, KIR2DL3, IL2RA

Molecular functions related to Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor activityGO:0048729.6KIR2DL1, KIR2DL3
2antigen bindingGO:0038238.9KIR2DL3, MICA

Products for genes affiliated with Large Granular Lymphocyte Leukemia

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Sources for Large Granular Lymphocyte Leukemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet