MCID: LRN004
MIFTS: 59

Laron Dwarfism malady

Categories: Genetic diseases, Rare diseases, Endocrine diseases

Aliases & Classifications for Laron Dwarfism

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Sources:
11Disease Ontology, 12diseasecard, 13DISEASES, 24GeneTests, 25Genetics Home Reference, 26GTR, 29ICD10, 30ICD10 via Orphanet, 36MedGen, 38MeSH, 39MESH via Orphanet, 47NIH Rare Diseases, 49Novoseek, 51OMIM, 53Orphanet, 61SNOMED-CT, 63The Human Phenotype Ontology, 67UMLS, 68UMLS via Orphanet, 69UniProtKB/Swiss-Prot
See all MalaCards sources

Aliases & Descriptions for Laron Dwarfism:

Name: Laron Dwarfism 51 47 25 69 12
Laron Syndrome 51 11 47 24 25 53 69 49 38 13 67
Growth Hormone Receptor Deficiency 47 25 53 69
Pituitary Dwarfism Ii 47 24 25 69
Laron-Type Isolated Somatotropin Defect 11 25 26
Growth Hormone Insensitivity Syndrome 47 25 69
Primary Growth Hormone Resistance 47 25 53
Primary Growth Hormone Insensitivity 47 53
Laron Type Pituitary Dwarfism I 47 69
Primary Gh Resistance 25 53
Laron-Type Dwarfism 25 53
 
Short Stature Due to Growth Hormone Resistance 53
Complete Growth Hormone Insensitivity 53
Growth Hormone Receptor Defect 25
Laron-Type Pituitary Dwarfism 25
Laron-Type Short Stature 25
Primary Gh Insensitivity 53
Severe Gh Insensitivity 25
Gh Receptor Deficiency 53
Gh-R Deficiency 25
Lars 69

Characteristics:

Orphanet epidemiological data:

53
laron syndrome:
Inheritance: Autosomal recessive; Prevalence: 1-9/1000000 (Europe); Age of onset: Infancy,Neonatal; Age of death: normal life expectancy

HPO:

63
laron dwarfism:
Inheritance: autosomal recessive inheritance

Classifications:



External Ids:

OMIM51 262500
Disease Ontology11 DOID:9521
ICD1029 E34.3
MeSH38 D046150
Orphanet53 ORPHA633
SNOMED-CT61 38196001
MESH via Orphanet39 D046150
UMLS via Orphanet68 C0271568
ICD10 via Orphanet30 E34.3
MedGen36 C0271568

Summaries for Laron Dwarfism

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OMIM:51 Laron syndrome is an autosomal recessive disorder characterized by marked short stature that results from failure to... (262500) more...

MalaCards based summary: Laron Dwarfism, also known as laron syndrome, is related to patellofemoral pain syndrome and growth hormone insensitivity, partial, and has symptoms including micrognathia, high forehead and delayed eruption of teeth. An important gene associated with Laron Dwarfism is GHR (Growth Hormone Receptor), and among its related pathways are EGFR Transactivation by Gastrin and Cardiac Progenitor Differentiation. Affiliated tissues include pituitary, brain and skeletal muscle, and related mouse phenotypes are muscle and adipose tissue.

Genetics Home Reference:25 Laron syndrome is a rare form of short stature that results from the body's inability to use growth hormone, a substance produced by the brain's pituitary gland that helps promote growth. Affected individuals are close to normal size at birth, but they experience slow growth from early childhood that results in very short stature. If the condition is not treated, adult males typically reach a maximum height of about 4.5 feet; adult females may be just over 4 feet tall.

NIH Rare Diseases:47 Laron syndrome is a condition that occurs when the body is unable to utilize growth hormone. It is primarily characterized by short stature. Other signs and symptoms vary but may include reduced muscle strength and endurance; hypoglycemia in infancy; delayed puberty; short limbs (arms and legs); and obesity. It is often caused by changes (mutations) in the GHR gene and is inherited in an autosomal recessive manner. Treatment is focused on improving growth and generally includes injections of insulin-like growth factor 1 (IGF-1). Last updated: 9/30/2015

UniProtKB/Swiss-Prot:69 Laron syndrome: A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone.

Wikipedia:70 Laron\'s syndrome, or Laron-type dwarfism, is an autosomal recessive disorder characterized by an... more...

Related Diseases for Laron Dwarfism

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Diseases related to Laron Dwarfism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1patellofemoral pain syndrome31.4IGF1, IGF2
2growth hormone insensitivity, partial28.9GH1, GHR, IGF1, IGF2, IGFBP3, STAT5B
3infantile liver failure syndrome 111.2
4pyuria11.2
5growth hormone insensitivity with immunodeficiency11.1
6michelin tire baby syndrome10.9
7desbuquois dysplasia 110.9
8osmotic diarrhea10.9
9conjugate gaze palsy10.9
10hiatus hernia10.9
11vaginal discharge10.9
12chronic salpingitis10.9
13dwarfism10.6
14acromegaly10.4
15acyl-coa dehydrogenase, short-chain, deficiency of10.3GHR, IGF1
16spinal muscular atrophy type 1 with congenital bone fractures10.2IGF1, IGFBP3
17seizures mental retardation hair dysplasia10.2IGF1, IGFBP3
18breast large cell neuroendocrine carcinoma10.2IGF1, IGFBP3
19cetp-related hyperalphalipoproteinemia10.2IGF1, IGFBP3
20necrotizing ulcerative gingivitis10.2IGF1, IGF2
21diarrhea 3, secretory sodium, congenital, syndromic10.2IGF1, IGFBP3
22rete ovarii cystadenofibroma10.2IGF1, IGFBP3
23epiphyseal chondrodysplasia, miura type10.2GHR, IGF1
24hallux varus and preaxial polysyndactyly10.2IGF1, IGF2
25multiple mitochondrial dysfunctions syndrome10.2IGF1, IGF2
26pituitary deficiency due to rathke's pouch cysts10.2GH1, GHR
27kartagener syndrome10.2IGF1, IGF2
28osteopetrosis10.1IGF1, IGF2
29vagina leiomyoma10.1IGF2, IGFBP3
30multifocal osteogenic sarcoma10.1GHR, IGFBP3
31hidradenitis10.1GHR, IGF1
32hyperinsulinemic hypoglycemia, familial, 510.1IGF1, IGFBP3
33splenic artery aneurysm10.1IGF1, IGF2
34sideroblastic anemia pyridoxine-responsive autosomal recessive10.1IGF2, IGFBP3
35perivascular epithelioid cell tumor10.1IGF1, IGF2
36lipoadenoma10.1GH1, GHR
37hypothryoidism, congenital, nongoitrous 410.1GH1, IGF1
38retinal dystrophies primarily involving bruch's membrane10.1IGF1, IGF2
39postural hypotension10.1GH1, IGF1
40albinism, oculocutaneous, type ia10.0IGF1, IGFBP3
41skull base neoplasm9.9GH1, IGF1
42congenital hypomyelination neuropathy9.9IGF1, IGFBP3
43insulin-like growth factor i9.9
44thyroid cancer9.9
45thyroiditis9.9
46gigantism9.9
47alpha-methylacyl-coa racemase deficiency9.9GH1, IGF1
48cerebellar vermis medulloblastoma9.9IGF1, IGFBP3
49dysostosis9.9IGF1, IGFBP3
50obesity9.8

Graphical network of the top 20 diseases related to Laron Dwarfism:



Diseases related to laron dwarfism

Symptoms for Laron Dwarfism

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Symptoms by clinical synopsis from OMIM:

262500

Clinical features from OMIM:

262500

Human phenotypes related to Laron Dwarfism:

 63 53 (show all 50)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 micrognathia63 53 hallmark (90%) Very frequent (99-80%) HP:0000347
2 high forehead63 53 hallmark (90%) Very frequent (99-80%) HP:0000348
3 delayed eruption of teeth63 53 hallmark (90%) Very frequent (99-80%) HP:0000684
4 microdontia63 53 hallmark (90%) Very frequent (99-80%) HP:0000691
5 truncal obesity63 53 hallmark (90%) Very frequent (99-80%) HP:0001956
6 abnormal facial shape63 53 hallmark (90%) Very frequent (99-80%) HP:0001999
7 delayed skeletal maturation63 53 hallmark (90%) Very frequent (99-80%) HP:0002750
8 reduced number of teeth63 53 hallmark (90%) Very frequent (99-80%) HP:0009804
9 aplasia/hypoplasia involving the nose63 53 hallmark (90%) Very frequent (99-80%) HP:0009924
10 everted lower lip vermilion63 hallmark (90%) HP:0000232
11 microcephaly63 hallmark (90%) HP:0000252
12 insulin resistance63 hallmark (90%) HP:0000855
13 abnormality of lipid metabolism63 hallmark (90%) HP:0003119
14 short stature63 hallmark (90%) HP:0004322
15 brachydactyly syndrome63 53 typical (50%) Frequent (79-30%) HP:0001156
16 short toe63 53 typical (50%) Frequent (79-30%) HP:0001831
17 hypoglycemia63 53 typical (50%) Frequent (79-30%) HP:0001943
18 skeletal muscle atrophy63 typical (50%) HP:0003202
19 hypoplasia of penis63 53 typical (50%) Frequent (79-30%) HP:0008736
20 abnormality of the elbow63 53 typical (50%) Frequent (79-30%) HP:0009811
21 underdeveloped supraorbital ridges63 53 typical (50%) Frequent (79-30%) HP:0009891
22 fine hair63 typical (50%) HP:0002213
23 type ii diabetes mellitus63 typical (50%) HP:0005978
24 depressed nasal ridge63 53 occasional (7.5%) Occasional (29-5%) HP:0000457
25 blue sclerae63 53 occasional (7.5%) Occasional (29-5%) HP:0000592
26 hypohidrosis63 53 occasional (7.5%) Occasional (29-5%) HP:0000966
27 hypertrichosis63 occasional (7.5%) HP:0000998
28 abnormality of the voice63 occasional (7.5%) HP:0001608
29 osteoarthritis63 53 occasional (7.5%) Occasional (29-5%) HP:0002758
30 prematurely aged appearance63 53 occasional (7.5%) Occasional (29-5%) HP:0007495
31 cognitive impairment63 occasional (7.5%) HP:0100543
32 abnormality of the fontanelles or cranial sutures63 occasional (7.5%) HP:0000235
33 hearing impairment63 occasional (7.5%) HP:0000365
34 diabetes insipidus63 occasional (7.5%) HP:0000873
35 abnormality of the nail63 occasional (7.5%) HP:0001597
36 abnormality of immune system physiology63 occasional (7.5%) HP:0010978
37 small face63 HP:0000274
38 abnormal joint morphology63 HP:0001367
39 high pitched voice63 53 Occasional (29-5%) HP:0001620
40 abnormality of metabolism/homeostasis63 HP:0001939
41 short long bone63 HP:0003026
42 severe short stature63 53 Very frequent (99-80%) HP:0003510
43 delayed menarche63 HP:0012569
44 abnormality of the endocrine system53 Very frequent (99-80%)
45 delayed puberty53 Frequent (79-30%)
46 abnormality of the skull53 Occasional (29-5%)
47 intellectual disability53 Occasional (29-5%)
48 motor delay53 Frequent (79-30%)
49 hypercholesterolemia53 Occasional (29-5%)
50 hypoplastic nasal bridge53 Very frequent (99-80%)

Drugs & Therapeutics for Laron Dwarfism

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Drugs for Laron Dwarfism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1HormonesPhase 2, Phase 313979
2Insulin, Globin ZincPhase 2, Phase 34523
3MitogensPhase 2, Phase 31526
4insulinPhase 2, Phase 34524
5Hypoglycemic AgentsPhase 25733
6Hormone AntagonistsPhase 212778
7Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 212767

Interventional clinical trials:

idNameStatusNCT IDPhase
1IGF-I/IGFBP-3 Therapy in Children and Adolescents With Growth Hormone Insenitivity Syndrome (GHIS) Such as Laron SyndromeCompletedNCT00368173Phase 2, Phase 3
2Long-Term Treatment With rhIGF-1 in GHISCompletedNCT00571727Phase 2, Phase 3
3Role of Growth Hormone Antagonism in Modulating Insulin Sensitivity in Subjects With Pre-diabetesCompletedNCT02023918Phase 2

Search NIH Clinical Center for Laron Dwarfism


Cochrane evidence based reviews: laron syndrome

Genetic Tests for Laron Dwarfism

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Genetic tests related to Laron Dwarfism:

id Genetic test Affiliating Genes
1 Laron-Type Isolated Somatotropin Defect26
2 Pituitary Dwarfism Ii24 GHR

Anatomical Context for Laron Dwarfism

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MalaCards organs/tissues related to Laron Dwarfism:

35
Pituitary, Brain, Skeletal muscle, Bone, Thyroid

Animal Models for Laron Dwarfism or affiliated genes

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MGI Mouse Phenotypes related to Laron Dwarfism:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.3GHR, IGF1, IGF2, IGFBP3
2MP:00053759.2GHR, IGF1, IGFBP3, STAT5B
3MP:00053709.0GHR, IGF2, IGFBP3, STAT5B
4MP:00053798.6GHR, IGF1, IGF2, IGFBP3, STAT5B
5MP:00107718.5GHR, IGF1, IGF2, IGFBP3, STAT5B
6MP:00053678.3GHR, IGF1, IGF2, STAT5B

Publications for Laron Dwarfism

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Articles related to Laron Dwarfism:

(show all 21)
idTitleAuthorsYear
1
Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. (9566924)
1998
2
Growth hormone insensitivity syndrome (Laron dwarfism). (9554471)
1998
3
Radiographic abnormalities in Laron dwarfism. (7800446)
1994
4
Laron dwarfism in the Arabian Gulf: a report of a sibship. (7505559)
1993
5
Lack of hormone binding in COS-7 cells expressing a mutated growth hormone receptor found in Laron dwarfism. (8450064)
1993
6
Recurrent nonsense mutations in the growth hormone receptor from patients with Laron dwarfism. (1999489)
1991
7
Effects of the infusion of insulin-like growth factor I in a child with growth hormone insensitivity syndrome (Laron dwarfism). (2023608)
1991
8
Laron dwarfism. (1670793)
1991
9
Molecular basis of Laron dwarfism. (18411163)
1991
10
Correction and withdrawal of conclusion--a child with phenotypic Laron dwarfism and normal somatomedin levels. (2288600)
1990
11
Growth hormone-receptor gene in Laron dwarfism. (2308623)
1990
12
A child with phenotypic Laron dwarfism and normal somatomedin levels. (2913494)
1989
13
Laron dwarfism and mutations of the growth hormone-receptor gene. (2779634)
1989
14
A child with phenotypic Laron dwarfism and normal somatomedin levels. (2725626)
1989
15
The molecular biology of Laron dwarfism and medullary thyroid cancer. (2571085)
1989
16
Laron dwarfism: cellular unresponsiveness to GH demonstrated on cultured lymphocytes by a cytochemical method. (3169682)
1988
17
Absence of serum growth hormone binding protein in patients with growth hormone receptor deficiency (Laron dwarfism). (3474620)
1987
18
Pathogenesis of Laron dwarfism. (7453788)
1981
19
Peripheral unresponsiveness to human growth hormone in Laron dwarfism. (6106895)
1980
20
Laron dwarfism: growth and immunoreactive insulin following treatment with human growth hormone. (1107504)
1976
21
Fractionation studies on plasma of normals and patients with Laron dwarfism and hypopituitary gigantism. (4762432)
1973

Variations for Laron Dwarfism

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UniProtKB/Swiss-Prot genetic disease variations for Laron Dwarfism:

69 (show all 18)
id Symbol AA change Variation ID SNP ID
1GHRp.Arg89LysVAR_002709
2GHRp.Phe114SerVAR_002710rs121909357
3GHRp.Val143AlaVAR_002711
4GHRp.Val162AspVAR_002712
5GHRp.Asp170HisVAR_002713rs121909366
6GHRp.Arg179CysVAR_002714rs121909362
7GHRp.Arg229GlyVAR_002715
8GHRp.Cys440PheVAR_013939rs6182
9GHRp.Cys56SerVAR_018426
10GHRp.Ser58LeuVAR_018427
11GHRp.Trp68ArgVAR_018428
12GHRp.Pro149GlnVAR_018429rs121909365
13GHRp.Ile171ThrVAR_018431rs121909367
14GHRp.Gln172ProVAR_018432rs121909368
15GHRp.Val173GlyVAR_018433rs121909369
16GHRp.Tyr226CysVAR_018434
17GHRp.Ser244IleVAR_018435
18GHRp.Asp262AsnVAR_018436

Clinvar genetic disease variations for Laron Dwarfism:

5 (show all 22)
id Gene Variation Type Significance SNP ID Assembly Location
1GHRGHR, EX4,6DELdeletionPathogenicChr na, -1: -1
2GHRNM_000163.4(GHR): c.341T> C (p.Phe114Ser)SNVPathogenicrs121909357GRCh37Chr 5, 42695093: 42695093
3GHRNM_000163.4(GHR): c.181C> T (p.Arg61Ter)SNVPathogenicrs121909358GRCh37Chr 5, 42689036: 42689036
4GHRNM_000163.4(GHR): c.168C> A (p.Cys56Ter)SNVPathogenicrs121909359GRCh37Chr 5, 42689023: 42689023
5GHRNM_000163.4(GHR): c.594A> G (p.Glu198=)SNVPathogenicrs121909360GRCh37Chr 5, 42700080: 42700080
6GHRNM_000163.4(GHR): c.703C> T (p.Arg235Ter)SNVPathogenicrs121909363GRCh37Chr 5, 42711393: 42711393
7GHRGHR, IVS4DS, G-A, +1SNVPathogenicChr na, -1: -1
8GHRGHR, 2-BP DEL, FS51TERdeletionPathogenicChr na, -1: -1
9GHRNM_000163.4(GHR): c.619-1G> TSNVPathogenicrs730880281GRCh37Chr 5, 42711308: 42711308
10GHRGHR, 2-BP DEL, FS234TERdeletionPathogenicChr na, -1: -1
11GHRNM_000163.4(GHR): c.515A> C (p.Gln172Pro)SNVPathogenicrs121909368GRCh37Chr 5, 42700001: 42700001
12GHRNM_000163.4(GHR): c.518T> G (p.Val173Gly)SNVPathogenicrs121909369GRCh37Chr 5, 42700004: 42700004
13GHRNM_000163.4(GHR): c.508G> C (p.Asp170His)SNVPathogenicrs121909366GRCh37Chr 5, 42699994: 42699994
14GHRNM_000163.4(GHR): c.512T> C (p.Ile171Thr)SNVPathogenicrs121909367GRCh37Chr 5, 42699998: 42699998
15GHRGHR, PSEUDOEXON(-1)A-GSNVPathogenicChr na, -1: -1
16GHRGHR, 22-BP DELdeletionPathogenicChr na, -1: -1
17GHRNM_000163.4(GHR): c.102G> A (p.Trp34Ter)SNVPathogenicrs121909370GRCh37Chr 5, 42629171: 42629171
18GHRNM_000163.4(GHR): c.1630A> C (p.Ile544Leu)SNVrisk factorrs6180GRCh37Chr 5, 42719239: 42719239
19GHRNM_000163.4(GHR): c.303C> A (p.Cys101Ter)SNVPathogenicrs121909371GRCh37Chr 5, 42695055: 42695055
20GHRGHR, 1-BP DEL, 1776GdeletionPathogenicChr na, -1: -1
21GHRNM_000163.4(GHR): c.335G> C (p.Cys112Ser)SNVPathogenicrs121909372GRCh37Chr 5, 42695087: 42695087
22GHRNM_000163.4(GHR): c.504T> G (p.His168Gln)SNVPathogenicrs121909373GRCh37Chr 5, 42699990: 42699990

Expression for genes affiliated with Laron Dwarfism

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Search GEO for disease gene expression data for Laron Dwarfism.

Pathways for genes affiliated with Laron Dwarfism

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Pathways related to Laron Dwarfism according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.5IGF1, IGF2
29.5IGF1, IGF2
39.5IGF1, IGF2
49.0GH1, GHR, IGF1
59.0IGF1, IGF2, IGFBP3
6
Show member pathways
9.0IGF1, IGF2, IGFBP3
7
Show member pathways
8.9GH1, IGF1, IGF2
8
Show member pathways
8.9GH1, IGF1, IGF2
98.9GH1, IGF1, IGF2
10
Show member pathways
8.6GH1, GHR, STAT5B
118.6GH1, IGF1, STAT5B
12
Show member pathways
8.5GH1, GHR, IGF1, IGFBP3
13
Show member pathways
8.1GH1, IGF1, IGF2, STAT5B
14
Show member pathways
7.6GH1, GHR, IGF1, IGF2, STAT5B
15
Show member pathways
7.6GH1, GHR, IGF1, IGF2, STAT5B
167.6GH1, GHR, IGF1, IGF2, STAT5B

GO Terms for genes affiliated with Laron Dwarfism

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Cellular components related to Laron Dwarfism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor ternary complexGO:004256710.2IGF1, IGFBP3
2insulin-like growth factor binding protein complexGO:001694210.2IGF1, IGFBP3
3platelet alpha granule lumenGO:003109310.1IGF1, IGF2
4extracellular spaceGO:00056157.9GH1, GHR, IGF1, IGF2, IGFBP3
5extracellular regionGO:00055767.6GH1, GHR, IGF1, IGF2, IGFBP3

Biological processes related to Laron Dwarfism according to GeneCards Suite gene sharing:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor signaling pathwayGO:004800910.1GHR, IGF1
2growth hormone receptor signaling pathwayGO:006039610.1GH1, GHR
3response to glucocorticoidGO:005138410.1GHR, IGF1
4positive regulation of glycogen biosynthetic processGO:004572510.1IGF1, IGF2
5negative regulation of neuron deathGO:190121510.0GHR, IGF1
6cellular response to insulin stimulusGO:003286910.0GHR, IGF1
7allantoin metabolic processGO:000025510.0GHR, STAT5B
8creatinine metabolic processGO:00464499.9GHR, STAT5B
9positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.9GH1, GHR
10oxaloacetate metabolic processGO:00061079.9GHR, STAT5B
11succinate metabolic processGO:00061059.9GHR, STAT5B
12taurine metabolic processGO:00195309.9GHR, STAT5B
13valine metabolic processGO:00065739.9GHR, STAT5B
14isoleucine metabolic processGO:00065499.9GHR, STAT5B
15positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.8GH1, IGF1
16creatine metabolic processGO:00066009.8GHR, STAT5B
17citrate metabolic processGO:00061019.8GHR, STAT5B
18positive regulation of JAK-STAT cascadeGO:00464279.8GH1, GHR
19cellular response to hormone stimulusGO:00328709.7GHR, STAT5B
20positive regulation of smooth muscle cell proliferationGO:00486619.7IGF1, STAT5B
21memoryGO:00076139.6IGF1, IGF2
22fatty acid metabolic processGO:00066319.6GHR, STAT5B
23positive regulation of catalytic activityGO:00430859.6IGF2, IGFBP3
24response to nicotineGO:00350949.6IGF1, IGF2
252-oxoglutarate metabolic processGO:00061039.5GHR, STAT5B
26positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.5GH1, GHR, IGF1
27positive regulation of insulin-like growth factor receptor signaling pathwayGO:00435689.5GH1, IGF1, IGFBP3
28cellular protein metabolic processGO:00442679.3IGF1, IGF2, IGFBP3
29positive regulation of activated T cell proliferationGO:00421049.3IGF1, IGF2, STAT5B
30positive regulation of MAPK cascadeGO:00434109.2IGF1, IGF2, IGFBP3
31positive regulation of mitotic nuclear divisionGO:00458409.2IGF1, IGF2
32JAK-STAT cascadeGO:00072599.1GH1, GHR, STAT5B
33JAK-STAT cascade involved in growth hormone signaling pathwayGO:00603979.1GH1, GHR, STAT5B
34female pregnancyGO:00075659.0IGF1, IGF2, STAT5B
35positive regulation of peptidyl-tyrosine phosphorylationGO:00507318.8GH1, GHR, IGF1, IGF2
36response to estradiolGO:00323558.7GH1, IGF2, STAT5B
37regulation of multicellular organism growthGO:00400148.7GHR, IGF1, STAT5B
38positive regulation of cell proliferationGO:00082848.7IGF1, IGF2, STAT5B
39positive regulation of multicellular organism growthGO:00400188.6GH1, GHR, STAT5B

Molecular functions related to Laron Dwarfism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:000515910.0IGF1, IGF2
2insulin receptor bindingGO:00051589.5IGF1, IGF2
3protein phosphatase bindingGO:00199039.4GHR, STAT5B
4hormone activityGO:00051799.1GH1, IGF1, IGF2
5growth factor activityGO:00080839.1GH1, IGF1, IGF2

Sources for Laron Dwarfism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet