LARS
MCID: LRN004
MIFTS: 58

Laron Dwarfism (LARS) malady

Categories: Genetic diseases, Rare diseases, Endocrine diseases

Aliases & Classifications for Laron Dwarfism

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Sources:
11Disease Ontology, 12diseasecard, 13DISEASES, 24GeneTests, 25Genetics Home Reference, 27GTR, 30ICD10, 31ICD10 via Orphanet, 37MedGen, 39MeSH, 40MESH via Orphanet, 48NIH Rare Diseases, 50Novoseek, 52OMIM, 54Orphanet, 62SNOMED-CT, 64The Human Phenotype Ontology, 68UMLS, 69UMLS via Orphanet, 70UniProtKB/Swiss-Prot
See all MalaCards sources

Aliases & Descriptions for Laron Dwarfism:

Name: Laron Dwarfism 52 48 25 70 12
Laron Syndrome 52 11 48 24 25 54 70 50 39 13 68
Growth Hormone Receptor Deficiency 48 25 54 70
Pituitary Dwarfism Ii 48 24 25 70
Laron-Type Isolated Somatotropin Defect 11 25 27
Growth Hormone Insensitivity Syndrome 48 25 70
Primary Growth Hormone Resistance 48 25 54
Primary Growth Hormone Insensitivity 48 54
Laron Type Pituitary Dwarfism I 48 70
Primary Gh Resistance 25 54
Laron-Type Dwarfism 25 54
 
Short Stature Due to Growth Hormone Resistance 54
Complete Growth Hormone Insensitivity 54
Growth Hormone Receptor Defect 25
Laron-Type Pituitary Dwarfism 25
Laron-Type Short Stature 25
Primary Gh Insensitivity 54
Severe Gh Insensitivity 25
Gh Receptor Deficiency 54
Gh-R Deficiency 25
Lars 70

Characteristics:

Orphanet epidemiological data:

54
laron syndrome:
Inheritance: Autosomal recessive; Prevalence: 1-9/1000000 (Europe); Age of onset: Infancy,Neonatal; Age of death: normal life expectancy

HPO:

64
laron dwarfism:
Inheritance: autosomal recessive inheritance

Classifications:



External Ids:

OMIM52 262500
Disease Ontology11 DOID:9521
ICD1030 E34.3
MeSH39 D046150
Orphanet54 ORPHA633
SNOMED-CT62 38196001
MESH via Orphanet40 D046150
UMLS via Orphanet69 C0271568
ICD10 via Orphanet31 E34.3
MedGen37 C0271568

Summaries for Laron Dwarfism

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OMIM:52 Laron syndrome is an autosomal recessive disorder characterized by marked short stature that results from failure to... (262500) more...

MalaCards based summary: Laron Dwarfism, also known as laron syndrome, is related to pyuria and infantile liver failure syndrome 1, and has symptoms including Array, Array and Array. An important gene associated with Laron Dwarfism is GHR (Growth Hormone Receptor), and among its related pathways are Cardiac Progenitor Differentiation and EGFR Transactivation by Gastrin. Affiliated tissues include pituitary, brain and bone, and related mouse phenotypes are Increased shRNA abundance (Z-score > 2) and muscle.

Genetics Home Reference:25 Laron syndrome is a rare form of short stature that results from the body's inability to use growth hormone, a substance produced by the brain's pituitary gland that helps promote growth. Affected individuals are close to normal size at birth, but they experience slow growth from early childhood that results in very short stature. If the condition is not treated, adult males typically reach a maximum height of about 4.5 feet; adult females may be just over 4 feet tall.

NIH Rare Diseases:48 Laron syndrome is a condition that occurs when the body is unable to utilize growth hormone. it is primarily characterized by short stature. other signs and symptoms vary but may include reduced muscle strength and endurance; hypoglycemia in infancy; delayed puberty; short limbs (arms and legs); and obesity. it is often caused by changes (mutations) in the ghr gene and is inherited in an autosomal recessive manner. treatment is focused on improving growth and generally includes injections of insulin-like growth factor 1 (igf-1). last updated: 9/30/2015

UniProtKB/Swiss-Prot:70 Laron syndrome: A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone.

Wikipedia:71 Laron\'s syndrome, or Laron-type dwarfism, is an autosomal recessive disorder characterized by an... more...

Related Diseases for Laron Dwarfism

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Diseases related to Laron Dwarfism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1pyuria11.2
2infantile liver failure syndrome 111.2
3growth hormone insensitivity with immunodeficiency11.1
4growth hormone insensitivity, partial11.1
5osmotic diarrhea10.9
6desbuquois dysplasia10.9
7conjugate gaze palsy10.9
8hiatus hernia10.9
9patellofemoral pain syndrome10.9
10vaginal discharge10.9
11chronic salpingitis10.9
12michelin tire baby syndrome10.9
13retinitis pigmentosa 6610.8
14desbuquois dysplasia 110.8
15mental retardation, x-linked, snyder-robinson type10.8
16dwarfism10.5
17acromegaly10.4
18deafness, autosomal dominant 2510.2GHR, IGF1
19short stature with nonspecific skeletal abnormalities10.2GHR, IGF1
20sohval soffer syndrome10.1IGF1, IGFBP3
21seow najjar syndrome10.1IGF1, IGFBP3
22capgras syndrome10.1IGF1, IGFBP3
23diarrhea 3, secretory sodium, congenital, syndromic10.1IGF1, IGFBP3
24lacrimal duct obstruction10.1IGF1, IGF2
25pituitary adenoma, acth-secreting10.1IGF1, IGFBP3
26femur bifid with monodactylous ectrodactyly10.1IGF1, IGF2
27hyperinsulinemic hypoglycemia, familial, 510.1IGF1, IGFBP3
28deafness, autosomal recessive 7410.1IGF1, IGF2
29coronary aneurysm10.1GHR, IGFBP3
30pemphigus vegetans10.1GH1, GHR
31ovarian insufficiency, familial10.1IGF1, IGF2
32phacolytic glaucoma10.1IGF1, IGFBP3
33critical congenital heart disease10.1GH1, IGF1
34bell's palsy10.1IGF2, IGFBP3
35brucella canis brucellosis10.1IGF1, IGF2
36mental retardation, autosomal recessive 3510.1IGF1, IGFBP3
37pulmonary neuroendocrine tumor10.1GH1, GHR
38haverhill fever10.1IGF1, IGF2
39caudal regression syndrome10.1GH1, IGF1
40harrod syndrome10.1IGF1, IGF2
41osseous heteroplasia, progressive10.1GH1, IGF1
42congenital articular rigidity10.1IGF2, IGFBP3
43primary effusion lymphoma10.1GH1, IGF1
44neurogenic arthropathy10.1IGF1, IGF2
45male genital organ stricture10.1GH1, IGFBP3
46post-traumatic stress disorder10.1IGF1, IGFBP3
47rheumatic encephalitis10.1GH1, IGF1
48ehlers-danlos syndrome, cardiac valvular form10.0IGF1, IGFBP3
49axial osteomalacia10.0GH1, IGF1
50urethra clear cell adenocarcinoma10.0GH1, IGF1

Graphical network of the top 20 diseases related to Laron Dwarfism:



Diseases related to laron dwarfism

Symptoms & Phenotypes for Laron Dwarfism

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Symptoms by clinical synopsis from OMIM:

262500

Clinical features from OMIM:

262500

Human phenotypes related to Laron Dwarfism:

 54 64 (show all 47)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 micrognathia64 54 Very frequent (99-80%) HP:0000347
2 high forehead64 54 Very frequent (99-80%) HP:0000348
3 depressed nasal ridge64 54 Occasional (29-5%) HP:0000457
4 blue sclerae64 54 Occasional (29-5%) HP:0000592
5 delayed eruption of teeth64 54 Very frequent (99-80%) HP:0000684
6 microdontia64 54 Very frequent (99-80%) HP:0000691
7 abnormality of the endocrine system54 Very frequent (99-80%)
8 delayed puberty64 54 Frequent (79-30%) HP:0000823
9 abnormality of the skull54 Occasional (29-5%)
10 hypohidrosis64 54 Occasional (29-5%) HP:0000966
11 brachydactyly syndrome64 54 Frequent (79-30%) HP:0001156
12 intellectual disability64 54 Occasional (29-5%) HP:0001249
13 motor delay64 54 Frequent (79-30%) HP:0001270
14 high pitched voice64 54 Occasional (29-5%) HP:0001620
15 short toe64 54 Frequent (79-30%) HP:0001831
16 hypoglycemia64 54 Frequent (79-30%) HP:0001943
17 truncal obesity64 54 Very frequent (99-80%) HP:0001956
18 abnormal facial shape64 54 Very frequent (99-80%) HP:0001999
19 delayed skeletal maturation64 54 Very frequent (99-80%) HP:0002750
20 osteoarthritis64 54 Occasional (29-5%) HP:0002758
21 hypercholesterolemia64 54 Occasional (29-5%) HP:0003124
22 severe short stature64 54 Very frequent (99-80%) HP:0003510
23 hypoplastic nasal bridge64 54 Very frequent (99-80%) HP:0005281
24 prematurely aged appearance64 54 Occasional (29-5%) HP:0007495
25 hypoplasia of penis64 54 Frequent (79-30%) HP:0008736
26 reduced number of teeth64 54 Very frequent (99-80%) HP:0009804
27 abnormality of the elbow64 54 Frequent (79-30%) HP:0009811
28 underdeveloped supraorbital ridges64 54 Frequent (79-30%) HP:0009891
29 aplasia/hypoplasia involving the nose64 54 Very frequent (99-80%) HP:0009924
30 small face64 HP:0000274
31 abnormal joint morphology64 HP:0001367
32 abnormality of metabolism/homeostasis64 HP:0001939
33 short long bone64 HP:0003026
34 delayed menarche64 HP:0012569
35 hypogonadism64 HP:0000135
36 everted lower lip vermilion64 HP:0000232
37 large fontanelles64 HP:0000239
38 microcephaly64 HP:0000252
39 hearing impairment64 HP:0000365
40 insulin resistance64 HP:0000855
41 diabetes insipidus64 HP:0000873
42 failure to thrive64 HP:0001508
43 abnormality of the nail64 HP:0001597
44 fine hair64 HP:0002213
45 immunodeficiency64 HP:0002721
46 short stature64 HP:0004322
47 type ii diabetes mellitus64 HP:0005978

GenomeRNAi Phenotypes related to Laron Dwarfism according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-1929.7GH1, IGF1, IGF2

MGI Mouse Phenotypes related to Laron Dwarfism according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.3GHR, IGF1, IGF2, IGFBP3
2MP:00053759.2GHR, IGF1, IGFBP3, STAT5B
3MP:00053709.0GHR, IGF2, IGFBP3, STAT5B
4MP:00053798.6GHR, IGF1, IGF2, IGFBP3, STAT5B
5MP:00107718.5GHR, IGF1, IGF2, IGFBP3, STAT5B
6MP:00053678.3GHR, IGF1, IGF2, STAT5B

Drugs & Therapeutics for Laron Dwarfism

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Drugs for Laron Dwarfism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1HormonesPhase 2, Phase 314415
2Insulin, Globin ZincPhase 2, Phase 34645
3MitogensPhase 2, Phase 31617
4insulinPhase 2, Phase 34646
5Hypoglycemic AgentsPhase 25896
6Hormone AntagonistsPhase 213180
7Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 213168

Interventional clinical trials:

idNameStatusNCT IDPhase
1IGF-I/IGFBP-3 Therapy in Children and Adolescents With Growth Hormone Insenitivity Syndrome (GHIS) Such as Laron SyndromeCompletedNCT00368173Phase 2, Phase 3
2Long-Term Treatment With rhIGF-1 in GHISCompletedNCT00571727Phase 2, Phase 3
3Role of Growth Hormone Antagonism in Modulating Insulin Sensitivity in Subjects With Pre-diabetesCompletedNCT02023918Phase 2

Search NIH Clinical Center for Laron Dwarfism


Cochrane evidence based reviews: laron syndrome

Genetic Tests for Laron Dwarfism

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Genetic tests related to Laron Dwarfism:

id Genetic test Affiliating Genes
1 Laron-Type Isolated Somatotropin Defect27
2 Pituitary Dwarfism Ii24 GHR

Anatomical Context for Laron Dwarfism

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MalaCards organs/tissues related to Laron Dwarfism:

36
Pituitary, Brain, Bone, Thyroid

Publications for Laron Dwarfism

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Articles related to Laron Dwarfism:

(show all 21)
idTitleAuthorsYear
1
Growth hormone insensitivity syndrome (Laron dwarfism). (9554471)
1998
2
Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. (9566924)
1998
3
Radiographic abnormalities in Laron dwarfism. (7800446)
1994
4
Lack of hormone binding in COS-7 cells expressing a mutated growth hormone receptor found in Laron dwarfism. (8450064)
1993
5
Laron dwarfism in the Arabian Gulf: a report of a sibship. (7505559)
1993
6
Recurrent nonsense mutations in the growth hormone receptor from patients with Laron dwarfism. (1999489)
1991
7
Molecular basis of Laron dwarfism. (18411163)
1991
8
Effects of the infusion of insulin-like growth factor I in a child with growth hormone insensitivity syndrome (Laron dwarfism). (2023608)
1991
9
Laron dwarfism. (1670793)
1991
10
Correction and withdrawal of conclusion--a child with phenotypic Laron dwarfism and normal somatomedin levels. (2288600)
1990
11
Growth hormone-receptor gene in Laron dwarfism. (2308623)
1990
12
The molecular biology of Laron dwarfism and medullary thyroid cancer. (2571085)
1989
13
A child with phenotypic Laron dwarfism and normal somatomedin levels. (2913494)
1989
14
A child with phenotypic Laron dwarfism and normal somatomedin levels. (2725626)
1989
15
Laron dwarfism and mutations of the growth hormone-receptor gene. (2779634)
1989
16
Laron dwarfism: cellular unresponsiveness to GH demonstrated on cultured lymphocytes by a cytochemical method. (3169682)
1988
17
Absence of serum growth hormone binding protein in patients with growth hormone receptor deficiency (Laron dwarfism). (3474620)
1987
18
Pathogenesis of Laron dwarfism. (7453788)
1981
19
Peripheral unresponsiveness to human growth hormone in Laron dwarfism. (6106895)
1980
20
Laron dwarfism: growth and immunoreactive insulin following treatment with human growth hormone. (1107504)
1976
21
Fractionation studies on plasma of normals and patients with Laron dwarfism and hypopituitary gigantism. (4762432)
1973

Variations for Laron Dwarfism

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UniProtKB/Swiss-Prot genetic disease variations for Laron Dwarfism:

70 (show all 18)
id Symbol AA change Variation ID SNP ID
1GHRp.Arg89LysVAR_002709
2GHRp.Phe114SerVAR_002710rs121909357
3GHRp.Val143AlaVAR_002711
4GHRp.Val162AspVAR_002712
5GHRp.Asp170HisVAR_002713rs121909366
6GHRp.Arg179CysVAR_002714rs121909362
7GHRp.Arg229GlyVAR_002715
8GHRp.Cys440PheVAR_013939rs6182
9GHRp.Cys56SerVAR_018426
10GHRp.Ser58LeuVAR_018427
11GHRp.Trp68ArgVAR_018428
12GHRp.Pro149GlnVAR_018429rs121909365
13GHRp.Ile171ThrVAR_018431rs121909367
14GHRp.Gln172ProVAR_018432rs121909368
15GHRp.Val173GlyVAR_018433rs121909369
16GHRp.Tyr226CysVAR_018434
17GHRp.Ser244IleVAR_018435
18GHRp.Asp262AsnVAR_018436

Clinvar genetic disease variations for Laron Dwarfism:

5 (show all 23)
id Gene Variation Type Significance SNP ID Assembly Location
1GHRNM_ 000163.4(GHR): c.281G> A (p.Trp94Ter)SNVLikely pathogenicrs1060499692GRCh37Chr 5, 42695033: 42695033
2GHRGHR, EX4,6DELdeletionPathogenic
3GHRNM_ 000163.4(GHR): c.341T> C (p.Phe114Ser)SNVPathogenicrs121909357GRCh37Chr 5, 42695093: 42695093
4GHRNM_ 000163.4(GHR): c.181C> T (p.Arg61Ter)SNVPathogenicrs121909358GRCh37Chr 5, 42689036: 42689036
5GHRNM_ 000163.4(GHR): c.168C> A (p.Cys56Ter)SNVPathogenicrs121909359GRCh37Chr 5, 42689023: 42689023
6GHRNM_ 000163.4(GHR): c.594A> G (p.Glu198=)SNVPathogenicrs121909360GRCh37Chr 5, 42700080: 42700080
7GHRNM_ 000163.4(GHR): c.703C> T (p.Arg235Ter)SNVPathogenicrs121909363GRCh37Chr 5, 42711393: 42711393
8GHRGHR, IVS4DS, G-A, +1SNVPathogenic
9GHRGHR, 2-BP DEL, FS51TERdeletionPathogenic
10GHRNM_ 000163.4(GHR): c.619-1G> TSNVPathogenicrs730880281GRCh38Chr 5, 42711206: 42711206
11GHRGHR, 2-BP DEL, FS234TERdeletionPathogenic
12GHRNM_ 000163.4(GHR): c.515A> C (p.Gln172Pro)SNVPathogenicrs121909368GRCh37Chr 5, 42700001: 42700001
13GHRNM_ 000163.4(GHR): c.518T> G (p.Val173Gly)SNVPathogenicrs121909369GRCh37Chr 5, 42700004: 42700004
14GHRNM_ 000163.4(GHR): c.508G> C (p.Asp170His)SNVPathogenicrs121909366GRCh37Chr 5, 42699994: 42699994
15GHRNM_ 000163.4(GHR): c.512T> C (p.Ile171Thr)SNVPathogenicrs121909367GRCh37Chr 5, 42699998: 42699998
16GHRGHR, PSEUDOEXON(-1)A-GSNVPathogenic
17GHRGHR, 22-BP DELdeletionPathogenic
18GHRNM_ 000163.4(GHR): c.102G> A (p.Trp34Ter)SNVPathogenicrs121909370GRCh37Chr 5, 42629171: 42629171
19GHRNM_ 000163.4(GHR): c.1630A> C (p.Ile544Leu)SNVrisk factorrs6180GRCh37Chr 5, 42719239: 42719239
20GHRNM_ 000163.4(GHR): c.303C> A (p.Cys101Ter)SNVPathogenicrs121909371GRCh37Chr 5, 42695055: 42695055
21GHRGHR, 1-BP DEL, 1776GdeletionPathogenic
22GHRNM_ 000163.4(GHR): c.335G> C (p.Cys112Ser)SNVPathogenicrs121909372GRCh37Chr 5, 42695087: 42695087
23GHRNM_ 000163.4(GHR): c.504T> G (p.His168Gln)SNVPathogenicrs121909373GRCh37Chr 5, 42699990: 42699990

Expression for genes affiliated with Laron Dwarfism

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Search GEO for disease gene expression data for Laron Dwarfism.

Pathways for genes affiliated with Laron Dwarfism

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Pathways related to Laron Dwarfism according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathwaysScoreTop Affiliating Genes
19.5IGF1, IGF2
2
Show member pathways
9.5IGF1, IGF2
39.5IGF1, IGF2
49.0GH1, GHR, IGF1
59.0IGF1, IGF2, IGFBP3
68.9GH1, IGF1, IGF2
7
Show member pathways
8.9GH1, IGF1, IGF2
8
Show member pathways
8.6GH1, GHR, STAT5B
9
Show member pathways
8.6GH1, GHR, STAT5B
108.6GH1, IGF1, STAT5B
11
Show member pathways
8.5GH1, GHR, IGF1, IGFBP3
12
Show member pathways
8.2IGF1, IGF2, IGFBP3, STAT5B
13
Show member pathways
8.1GH1, IGF1, IGF2, STAT5B
147.6GH1, GHR, IGF1, IGF2, STAT5B
15
Show member pathways
7.6GH1, GHR, IGF1, IGF2, STAT5B
16
Show member pathways
7.6GH1, GHR, IGF1, IGF2, STAT5B

GO Terms for genes affiliated with Laron Dwarfism

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Cellular components related to Laron Dwarfism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor binding protein complexGO:001694210.0IGF1, IGFBP3
2insulin-like growth factor ternary complexGO:004256710.0IGF1, IGFBP3
3growth hormone receptor complexGO:00701959.9GH1, GHR
4platelet alpha granule lumenGO:00310939.5IGF1, IGF2
5extracellular regionGO:00055768.7GH1, GHR, IGF1, IGF2, IGFBP3
6extracellular spaceGO:00056158.4GH1, GHR, IGF1, IGF2, IGFBP3

Biological processes related to Laron Dwarfism according to GeneCards Suite gene sharing:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor signaling pathwayGO:004800910.3GHR, IGF1
2growth hormone receptor signaling pathwayGO:006039610.1GH1, GHR
3positive regulation of glycogen biosynthetic processGO:004572510.1IGF1, IGF2
4positive regulation of mitotic nuclear divisionGO:004584010.1IGF1, IGF2
5positive regulation of JAK-STAT cascadeGO:004642710.1GH1, GHR
62-oxoglutarate metabolic processGO:000610310.0GHR, STAT5B
7allantoin metabolic processGO:000025510.0GHR, STAT5B
8positive regulation of phosphatidylinositol 3-kinase signalingGO:001406810.0GH1, IGF1
9cellular response to hormone stimulusGO:003287010.0GHR, STAT5B
10citrate metabolic processGO:000610110.0GHR, STAT5B
11creatine metabolic processGO:000660010.0GHR, STAT5B
12creatinine metabolic processGO:004644910.0GHR, STAT5B
13isoleucine metabolic processGO:00065499.9GHR, STAT5B
14oxaloacetate metabolic processGO:00061079.9GHR, STAT5B
15positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.9GH1, GHR
16cellular protein metabolic processGO:00442679.7IGF1, IGF2, IGFBP3
17positive regulation of MAPK cascadeGO:00434109.6IGF1, IGF2, IGFBP3
18positive regulation of insulin-like growth factor receptor signaling pathwayGO:00435689.5GH1, IGF1, IGFBP3
19positive regulation of tyrosine phosphorylation of STAT proteinGO:00425319.5GH1, GHR, IGF1
20succinate metabolic processGO:00061059.5GHR, STAT5B
21positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.4GH1, GHR, IGF1
22positive regulation of activated T cell proliferationGO:00421049.4IGF1, IGF2, STAT5B
23taurine metabolic processGO:00195309.4GHR, STAT5B
24positive regulation of cell proliferationGO:00082849.3IGF1, IGF2, STAT5B
25JAK-STAT cascadeGO:00072599.3GH1, GHR, STAT5B
26JAK-STAT cascade involved in growth hormone signaling pathwayGO:00603979.3GH1, GHR, STAT5B
27valine metabolic processGO:00065739.2GHR, STAT5B
28positive regulation of multicellular organism growthGO:00400189.2GH1, GHR, STAT5B
29regulation of multicellular organism growthGO:00400149.1GHR, IGF1, STAT5B
30positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.1GH1, GHR, IGF1, IGF2

Molecular functions related to Laron Dwarfism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor bindingGO:000515810.0IGF1, IGF2
2insulin-like growth factor receptor bindingGO:000515910.0IGF1, IGF2
3growth factor activityGO:00080839.5GH1, IGF1, IGF2
4hormone activityGO:00051799.4GH1, IGF1, IGF2
5protein phosphatase bindingGO:00199039.2GHR, STAT5B

Sources for Laron Dwarfism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet