MCID: LRN004
MIFTS: 58

Laron Dwarfism malady

Categories: Genetic diseases, Rare diseases, Endocrine diseases

Aliases & Classifications for Laron Dwarfism

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Sources:
50OMIM, 11Disease Ontology, 46NIH Rare Diseases, 23GeneTests, 24Genetics Home Reference, 13DISEASES, 52Orphanet, 68UniProtKB/Swiss-Prot, 25GTR, 12diseasecard, 48Novoseek, 37MeSH, 66UMLS, 28ICD10, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 35MedGen, 60SNOMED-CT, 62The Human Phenotype Ontology
See all MalaCards sources

Aliases & Descriptions for Laron Dwarfism:

Name: Laron Dwarfism 50 46 24 68 12
Laron Syndrome 50 11 46 23 24 13 52 68 48 37 66
Growth Hormone Receptor Deficiency 46 24 52 68
Pituitary Dwarfism Ii 46 23 24 68
Laron-Type Isolated Somatotropin Defect 11 24 25
Growth Hormone Insensitivity Syndrome 46 24 68
Primary Growth Hormone Resistance 46 24 52
Primary Growth Hormone Insensitivity 46 52
Laron Type Pituitary Dwarfism I 46 68
Primary Gh Resistance 24 52
Laron-Type Dwarfism 24 52
 
Short Stature Due to Growth Hormone Resistance 52
Complete Growth Hormone Insensitivity 52
Growth Hormone Receptor Defect 24
Laron-Type Pituitary Dwarfism 24
Laron-Type Short Stature 24
Primary Gh Insensitivity 52
Severe Gh Insensitivity 24
Gh Receptor Deficiency 52
Gh-R Deficiency 24
Lars 68

Characteristics:

Orphanet epidemiological data:

52
laron syndrome:
Inheritance: Autosomal recessive; Prevalence: 1-9/1000000 (Europe); Age of onset: Infancy,Neonatal; Age of death: normal life expectancy

HPO:

62
laron dwarfism:
Inheritance: autosomal recessive inheritance


Classifications:



External Ids:

OMIM50 262500
Disease Ontology11 DOID:9521
ICD1028 E34.3
MeSH37 D046150
Orphanet52 ORPHA633
SNOMED-CT60 38196001
ICD10 via Orphanet29 E34.3
MESH via Orphanet38 D046150
UMLS via Orphanet67 C0271568
MedGen35 C0271568

Summaries for Laron Dwarfism

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OMIM:50 Laron syndrome is an autosomal recessive disorder characterized by marked short stature that results from failure to... (262500) more...

MalaCards based summary: Laron Dwarfism, also known as laron syndrome, is related to patellofemoral pain syndrome and growth hormone insensitivity, partial, and has symptoms including micrognathia, high forehead and delayed eruption of teeth. An important gene associated with Laron Dwarfism is GHR (Growth Hormone Receptor), and among its related pathways are Cardiac Progenitor Differentiation and Cell adhesion_ECM remodeling. Affiliated tissues include pituitary, brain and skeletal muscle, and related mouse phenotypes are muscle and liver/biliary system.

NIH Rare Diseases:46 Laron syndrome is a condition that occurs when the body is unable to utilize growth hormone. it is primarily characterized by short stature. other signs and symptoms vary but may include reduced muscle strength and endurance; hypoglycemia in infancy; delayed puberty; short limbs (arms and legs); and obesity. it is often caused by changes (mutations) in the ghr gene and is inherited in an autosomal recessive manner. treatment is focused on improving growth and generally includes injections of insulin-like growth factor 1 (igf-1). last updated: 9/30/2015

UniProtKB/Swiss-Prot:68 Laron syndrome: A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone.

Genetics Home Reference:24 Laron syndrome is a rare form of short stature that results from the body's inability to use growth hormone, a substance produced by the brain's pituitary gland that helps promote growth. Affected individuals are close to normal size at birth, but they experience slow growth from early childhood that results in very short stature. If the condition is not treated, adult males typically reach a maximum height of about 4.5 feet; adult females may be just over 4 feet tall.

Wikipedia:69 Laron\'s syndrome, or Laron-type dwarfism, is an autosomal recessive disorder characterized by an... more...

Related Diseases for Laron Dwarfism

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Diseases related to Laron Dwarfism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1patellofemoral pain syndrome31.7IGF1, IGF2
2growth hormone insensitivity, partial28.8GH1, GHR, IGF1, IGF2, IGFBP3, STAT5B
3infantile liver failure syndrome 111.3
4pyuria11.3
5growth hormone insensitivity with immunodeficiency11.2
6acute liver failure11.0
7osmotic diarrhea11.0
8desbuquois dysplasia11.0
9conjugate gaze palsy11.0
10hiatus hernia11.0
11vaginal discharge11.0
12chronic salpingitis11.0
13dwarfism10.7
14acromegaly10.5
15acyl-coa dehydrogenase, short-chain, deficiency of10.4GHR, IGF1
16spinal muscular atrophy type 1 with congenital bone fractures10.3IGF1, IGFBP3
17seizures mental retardation hair dysplasia10.3IGF1, IGFBP3
18breast large cell neuroendocrine carcinoma10.3IGF1, IGFBP3
19cetp-related hyperalphalipoproteinemia10.3IGF1, IGFBP3
20epiphyseal chondrodysplasia, miura type10.3GHR, IGF1
21necrotizing ulcerative gingivitis10.3IGF1, IGF2
22diarrhea 3, secretory sodium, congenital, syndromic10.2IGF1, IGFBP3
23rete ovarii cystadenofibroma10.2IGF1, IGFBP3
24hallux varus and preaxial polysyndactyly10.2IGF1, IGF2
25multiple mitochondrial dysfunctions syndrome10.2IGF1, IGF2
26pituitary deficiency due to rathke's pouch cysts10.2GH1, GHR
27kartagener syndrome10.2IGF1, IGF2
28multifocal osteogenic sarcoma10.2GHR, IGFBP3
29osteopetrosis10.2IGF1, IGF2
30hidradenitis10.2GHR, IGF1
31vagina leiomyoma10.2IGF2, IGFBP3
32hyperinsulinemic hypoglycemia, familial, 510.2IGF1, IGFBP3
33splenic artery aneurysm10.2IGF1, IGF2
34perivascular epithelioid cell tumor10.2IGF1, IGF2
35sideroblastic anemia pyridoxine-responsive autosomal recessive10.2IGF2, IGFBP3
36lipoadenoma10.1GH1, GHR
37hypothryoidism, congenital, nongoitrous 410.1GH1, IGF1
38retinal dystrophies primarily involving bruch's membrane10.1IGF1, IGF2
39postural hypotension10.1GH1, IGF1
40laryngeal carcinoma10.1IGF1, IGF2
41sost-related sclerosing bone dysplasia10.0GH1, IGF1
42albinism, oculocutaneous, type ia10.0IGF1, IGFBP3
43insulin-like growth factor i10.0
44thyroid cancer10.0
45thyroiditis10.0
46gigantism10.0
47myotonic dystrophy 110.0
48skull base neoplasm10.0GH1, IGF1
49obesity9.9
50pituitary adenoma9.9

Graphical network of the top 20 diseases related to Laron Dwarfism:



Diseases related to laron dwarfism

Symptoms for Laron Dwarfism

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Symptoms by clinical synopsis from OMIM:

262500

Clinical features from OMIM:

262500

Symptoms:

 52 (show all 29)
  • micrognathia
  • high forehead
  • depressed nasal ridge
  • blue sclerae
  • delayed eruption of teeth
  • microdontia
  • abnormality of the endocrine system
  • delayed puberty
  • abnormality of the skull
  • hypohidrosis
  • brachydactyly syndrome
  • intellectual disability
  • motor delay
  • high pitched voice
  • short toe
  • hypoglycemia
  • truncal obesity
  • abnormal facial shape
  • delayed skeletal maturation
  • osteoarthritis
  • hypercholesterolemia
  • severe short stature
  • hypoplastic nasal bridge
  • prematurely aged appearance
  • hypoplasia of penis
  • reduced number of teeth
  • abnormality of the elbow
  • underdeveloped supraorbital ridges
  • aplasia/hypoplasia involving the nose

HPO human phenotypes related to Laron Dwarfism:

(show all 49)
id Description Frequency HPO Source Accession
1 micrognathia hallmark (90%) HP:0000347
2 high forehead hallmark (90%) HP:0000348
3 delayed eruption of teeth hallmark (90%) HP:0000684
4 microdontia hallmark (90%) HP:0000691
5 truncal obesity hallmark (90%) HP:0001956
6 abnormal facial shape hallmark (90%) HP:0001999
7 delayed skeletal maturation hallmark (90%) HP:0002750
8 reduced number of teeth hallmark (90%) HP:0009804
9 aplasia/hypoplasia involving the nose hallmark (90%) HP:0009924
10 everted lower lip vermilion hallmark (90%) HP:0000232
11 microcephaly hallmark (90%) HP:0000252
12 insulin resistance hallmark (90%) HP:0000855
13 abnormality of lipid metabolism hallmark (90%) HP:0003119
14 short stature hallmark (90%) HP:0004322
15 brachydactyly syndrome typical (50%) HP:0001156
16 short toe typical (50%) HP:0001831
17 hypoglycemia typical (50%) HP:0001943
18 skeletal muscle atrophy typical (50%) HP:0003202
19 hypoplasia of penis typical (50%) HP:0008736
20 abnormality of the elbow typical (50%) HP:0009811
21 underdeveloped supraorbital ridges typical (50%) HP:0009891
22 delayed eruption of teeth typical (50%) HP:0000684
23 fine hair typical (50%) HP:0002213
24 delayed skeletal maturation typical (50%) HP:0002750
25 type ii diabetes mellitus typical (50%) HP:0005978
26 depressed nasal ridge occasional (7.5%) HP:0000457
27 blue sclerae occasional (7.5%) HP:0000592
28 hypohidrosis occasional (7.5%) HP:0000966
29 hypertrichosis occasional (7.5%) HP:0000998
30 abnormality of the voice occasional (7.5%) HP:0001608
31 osteoarthritis occasional (7.5%) HP:0002758
32 abnormality of lipid metabolism occasional (7.5%) HP:0003119
33 prematurely aged appearance occasional (7.5%) HP:0007495
34 cognitive impairment occasional (7.5%) HP:0100543
35 abnormality of the fontanelles or cranial sutures occasional (7.5%) HP:0000235
36 hearing impairment occasional (7.5%) HP:0000365
37 diabetes insipidus occasional (7.5%) HP:0000873
38 abnormality of the nail occasional (7.5%) HP:0001597
39 truncal obesity occasional (7.5%) HP:0001956
40 abnormality of immune system physiology occasional (7.5%) HP:0010978
41 small face HP:0000274
42 blue sclerae HP:0000592
43 abnormal joint morphology HP:0001367
44 high pitched voice HP:0001620
45 abnormality of metabolism/homeostasis HP:0001939
46 delayed skeletal maturation HP:0002750
47 short long bone HP:0003026
48 severe short stature HP:0003510
49 delayed menarche HP:0012569

Drugs & Therapeutics for Laron Dwarfism

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Drugs for Laron Dwarfism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1insulinPhase 2, Phase 34401

Interventional clinical trials:

idNameStatusNCT IDPhase
1IGF-I/IGFBP-3 Therapy in Children and Adolescents With Growth Hormone Insenitivity Syndrome (GHIS) Such as Laron SyndromeCompletedNCT00368173Phase 2, Phase 3
2Long-Term Treatment With rhIGF-1 in GHISCompletedNCT00571727Phase 2, Phase 3
3Role of Growth Hormone Antagonism in Modulating Insulin Sensitivity in Subjects With Pre-diabetesCompletedNCT02023918Phase 2

Search NIH Clinical Center for Laron Dwarfism


Cochrane evidence based reviews: laron syndrome

Genetic Tests for Laron Dwarfism

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Genetic tests related to Laron Dwarfism:

id Genetic test Affiliating Genes
1 Laron-Type Isolated Somatotropin Defect25
2 Pituitary Dwarfism Ii23 GHR

Anatomical Context for Laron Dwarfism

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MalaCards organs/tissues related to Laron Dwarfism:

34
Pituitary, Brain, Skeletal muscle, Bone, Thyroid

Animal Models for Laron Dwarfism or affiliated genes

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MGI Mouse Phenotypes related to Laron Dwarfism:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.0GHR, IGF1, IGF2, IGFBP3
2MP:00053708.7GHR, IGF2, IGFBP3, STAT5B
3MP:00053758.6GHR, IGF1, IGFBP3, STAT5B
4MP:00053678.4GHR, IGF1, IGF2, STAT5B
5MP:00107718.3GHR, IGF1, IGF2, IGFBP3, STAT5B
6MP:00053797.9GHR, IGF1, IGF2, IGFBP3, STAT5B

Publications for Laron Dwarfism

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Articles related to Laron Dwarfism:

(show all 21)
idTitleAuthorsYear
1
Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. (9566924)
1998
2
Growth hormone insensitivity syndrome (Laron dwarfism). (9554471)
1998
3
Radiographic abnormalities in Laron dwarfism. (7800446)
1994
4
Laron dwarfism in the Arabian Gulf: a report of a sibship. (7505559)
1993
5
Lack of hormone binding in COS-7 cells expressing a mutated growth hormone receptor found in Laron dwarfism. (8450064)
1993
6
Recurrent nonsense mutations in the growth hormone receptor from patients with Laron dwarfism. (1999489)
1991
7
Effects of the infusion of insulin-like growth factor I in a child with growth hormone insensitivity syndrome (Laron dwarfism). (2023608)
1991
8
Laron dwarfism. (1670793)
1991
9
Molecular basis of Laron dwarfism. (18411163)
1991
10
Correction and withdrawal of conclusion--a child with phenotypic Laron dwarfism and normal somatomedin levels. (2288600)
1990
11
Growth hormone-receptor gene in Laron dwarfism. (2308623)
1990
12
A child with phenotypic Laron dwarfism and normal somatomedin levels. (2913494)
1989
13
Laron dwarfism and mutations of the growth hormone-receptor gene. (2779634)
1989
14
A child with phenotypic Laron dwarfism and normal somatomedin levels. (2725626)
1989
15
The molecular biology of Laron dwarfism and medullary thyroid cancer. (2571085)
1989
16
Laron dwarfism: cellular unresponsiveness to GH demonstrated on cultured lymphocytes by a cytochemical method. (3169682)
1988
17
Absence of serum growth hormone binding protein in patients with growth hormone receptor deficiency (Laron dwarfism). (3474620)
1987
18
Pathogenesis of Laron dwarfism. (7453788)
1981
19
Peripheral unresponsiveness to human growth hormone in Laron dwarfism. (6106895)
1980
20
Laron dwarfism: growth and immunoreactive insulin following treatment with human growth hormone. (1107504)
1976
21
Fractionation studies on plasma of normals and patients with Laron dwarfism and hypopituitary gigantism. (4762432)
1973

Variations for Laron Dwarfism

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UniProtKB/Swiss-Prot genetic disease variations for Laron Dwarfism:

68 (show all 18)
id Symbol AA change Variation ID SNP ID
1GHRp.Arg89LysVAR_002709
2GHRp.Phe114SerVAR_002710rs121909357
3GHRp.Val143AlaVAR_002711
4GHRp.Val162AspVAR_002712
5GHRp.Asp170HisVAR_002713rs121909366
6GHRp.Arg179CysVAR_002714rs121909362
7GHRp.Arg229GlyVAR_002715
8GHRp.Cys440PheVAR_013939rs6182
9GHRp.Cys56SerVAR_018426
10GHRp.Ser58LeuVAR_018427
11GHRp.Trp68ArgVAR_018428
12GHRp.Pro149GlnVAR_018429rs121909365
13GHRp.Ile171ThrVAR_018431rs121909367
14GHRp.Gln172ProVAR_018432rs121909368
15GHRp.Val173GlyVAR_018433rs121909369
16GHRp.Tyr226CysVAR_018434
17GHRp.Ser244IleVAR_018435
18GHRp.Asp262AsnVAR_018436

Clinvar genetic disease variations for Laron Dwarfism:

5 (show all 21)
id Gene Variation Type Significance SNP ID Assembly Location
1GHRGHR, EX4,6DELdeletionPathogenic
2GHRNM_000163.4(GHR): c.341T> C (p.Phe114Ser)single nucleotide variantPathogenicrs121909357GRCh37Chr 5, 42695093: 42695093
3GHRNM_000163.4(GHR): c.181C> T (p.Arg61Ter)single nucleotide variantPathogenicrs121909358GRCh37Chr 5, 42689036: 42689036
4GHRNM_000163.4(GHR): c.168C> A (p.Cys56Ter)single nucleotide variantPathogenicrs121909359GRCh37Chr 5, 42689023: 42689023
5GHRNM_000163.4(GHR): c.594A> G (p.Glu198=)single nucleotide variantPathogenicrs121909360GRCh37Chr 5, 42700080: 42700080
6GHRNM_000163.4(GHR): c.703C> T (p.Arg235Ter)single nucleotide variantPathogenicrs121909363GRCh37Chr 5, 42711393: 42711393
7GHRGHR, IVS4DS, G-A, +1single nucleotide variantPathogenic
8GHRGHR, 2-BP DEL, FS51TERdeletionPathogenic
9GHRNM_000163.4(GHR): c.619-1G> Tsingle nucleotide variantPathogenicrs730880281GRCh38Chr 5, 42711206: 42711206
10GHRGHR, 2-BP DEL, FS234TERdeletionPathogenic
11GHRNM_000163.4(GHR): c.515A> C (p.Gln172Pro)single nucleotide variantPathogenicrs121909368GRCh37Chr 5, 42700001: 42700001
12GHRNM_000163.4(GHR): c.518T> G (p.Val173Gly)single nucleotide variantPathogenicrs121909369GRCh37Chr 5, 42700004: 42700004
13GHRNM_000163.4(GHR): c.508G> C (p.Asp170His)single nucleotide variantPathogenicrs121909366GRCh37Chr 5, 42699994: 42699994
14GHRNM_000163.4(GHR): c.512T> C (p.Ile171Thr)single nucleotide variantPathogenicrs121909367GRCh37Chr 5, 42699998: 42699998
15GHRGHR, PSEUDOEXON(-1)A-Gsingle nucleotide variantPathogenic
16GHRGHR, 22-BP DELdeletionPathogenic
17GHRNM_000163.4(GHR): c.102G> A (p.Trp34Ter)single nucleotide variantPathogenicrs121909370GRCh37Chr 5, 42629171: 42629171
18GHRNM_000163.4(GHR): c.303C> A (p.Cys101Ter)single nucleotide variantPathogenicrs121909371GRCh37Chr 5, 42695055: 42695055
19GHRGHR, 1-BP DEL, 1776GdeletionPathogenic
20GHRNM_000163.4(GHR): c.335G> C (p.Cys112Ser)single nucleotide variantPathogenicrs121909372GRCh37Chr 5, 42695087: 42695087
21GHRNM_000163.4(GHR): c.504T> G (p.His168Gln)single nucleotide variantPathogenicrs121909373GRCh37Chr 5, 42699990: 42699990

Expression for genes affiliated with Laron Dwarfism

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Search GEO for disease gene expression data for Laron Dwarfism.

Pathways for genes affiliated with Laron Dwarfism

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Pathways related to Laron Dwarfism according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
19.5IGF1, IGF2
29.5IGF1, IGF2
3
Show member pathways
9.5IGF1, IGF2
49.0GH1, GHR, IGF1
5
Show member pathways
9.0IGF1, IGF2, IGFBP3
69.0IGF1, IGF2, IGFBP3
7
Show member pathways
8.9GH1, IGF1, IGF2
8
Show member pathways
8.9GH1, IGF1, IGF2
98.9GH1, IGF1, IGF2
10
Show member pathways
8.6GH1, GHR, STAT5B
11
Show member pathways
8.6GH1, GHR, STAT5B
128.6GH1, GHR, STAT5B
138.6GH1, IGF1, STAT5B
14
Show member pathways
8.5GH1, GHR, IGF1, IGFBP3
15
Show member pathways
8.1GH1, IGF1, IGF2, STAT5B
16
Show member pathways
7.6GH1, GHR, IGF1, IGF2, STAT5B
177.6GH1, GHR, IGF1, IGF2, STAT5B
18
Show member pathways
7.6GH1, GHR, IGF1, IGF2, STAT5B

GO Terms for genes affiliated with Laron Dwarfism

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Cellular components related to Laron Dwarfism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor ternary complexGO:004256710.2IGF1, IGFBP3
2insulin-like growth factor binding protein complexGO:001694210.2IGF1, IGFBP3
3platelet alpha granule lumenGO:003109310.1IGF1, IGF2
4extracellular spaceGO:00056157.9GH1, GHR, IGF1, IGF2, IGFBP3
5extracellular regionGO:00055767.6GH1, GHR, IGF1, IGF2, IGFBP3

Biological processes related to Laron Dwarfism according to GeneCards Suite gene sharing:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1response to glucocorticoidGO:005138410.1GHR, IGF1
2growth hormone receptor signaling pathwayGO:006039610.1GH1, GHR
3insulin-like growth factor receptor signaling pathwayGO:004800910.1GHR, IGF1
4positive regulation of glycogen biosynthetic processGO:004572510.1IGF1, IGF2
5negative regulation of neuron deathGO:190121510.0GHR, IGF1
6positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.9GH1, GHR
7creatinine metabolic processGO:00464499.9GHR, STAT5B
8allantoin metabolic processGO:00002559.9GHR, STAT5B
9oxaloacetate metabolic processGO:00061079.9GHR, STAT5B
10succinate metabolic processGO:00061059.9GHR, STAT5B
11taurine metabolic processGO:00195309.9GHR, STAT5B
12valine metabolic processGO:00065739.9GHR, STAT5B
13isoleucine metabolic processGO:00065499.9GHR, STAT5B
14positive regulation of JAK-STAT cascadeGO:00464279.9GH1, GHR
15creatine metabolic processGO:00066009.8GHR, STAT5B
16cellular response to insulin stimulusGO:00328699.8GHR, IGF1
17positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.8GH1, IGF1
18citrate metabolic processGO:00061019.8GHR, STAT5B
19fatty acid metabolic processGO:00066319.7GHR, STAT5B
20cellular response to hormone stimulusGO:00328709.7GHR, STAT5B
21positive regulation of smooth muscle cell proliferationGO:00486619.7IGF1, STAT5B
22positive regulation of catalytic activityGO:00430859.7IGF2, IGFBP3
23memoryGO:00076139.6IGF1, IGF2
242-oxoglutarate metabolic processGO:00061039.6GHR, STAT5B
25response to nicotineGO:00350949.6IGF1, IGF2
26positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.5GH1, GHR, IGF1
27positive regulation of insulin-like growth factor receptor signaling pathwayGO:00435689.5GH1, IGF1, IGFBP3
28cellular protein metabolic processGO:00442679.3IGF1, IGF2, IGFBP3
29JAK-STAT cascade involved in growth hormone signaling pathwayGO:00603979.3GH1, GHR, STAT5B
30positive regulation of MAPK cascadeGO:00434109.3IGF1, IGF2, IGFBP3
31positive regulation of activated T cell proliferationGO:00421049.3IGF1, IGF2, STAT5B
32positive regulation of mitotic nuclear divisionGO:00458409.2IGF1, IGF2
33JAK-STAT cascadeGO:00072599.1GH1, GHR, STAT5B
34female pregnancyGO:00075659.0IGF1, IGF2, STAT5B
35positive regulation of peptidyl-tyrosine phosphorylationGO:00507318.9GH1, GHR, IGF1, IGF2
36regulation of multicellular organism growthGO:00400148.7GHR, IGF1, STAT5B
37positive regulation of cell proliferationGO:00082848.7IGF1, IGF2, STAT5B
38positive regulation of multicellular organism growthGO:00400188.6GH1, GHR, STAT5B
39response to estradiolGO:00323558.6GH1, IGF2, STAT5B

Molecular functions related to Laron Dwarfism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:000515910.0IGF1, IGF2
2insulin receptor bindingGO:00051589.5IGF1, IGF2
3hormone activityGO:00051799.2GH1, IGF1, IGF2
4protein phosphatase bindingGO:00199039.1GHR, STAT5B
5growth factor activityGO:00080839.1GH1, IGF1, IGF2

Sources for Laron Dwarfism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet