MCID: LRN002
MIFTS: 76

Laron Syndrome malady

Endocrine diseases category

Summaries for Laron Syndrome

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42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Laron syndrome is a disorder chiefly characterized by marked short stature. signs and symptoms in the newborn period typically include low blood sugar (hypoglycemia) and having an unusually small penis (micropenis). affected children have slow and disproportionate growth, delayed motor development due to decreased muscle mass, and delayed puberty. other signs and symptoms include distinctive facial features (protruding and high forehead, shallow eye sockets, underdeveloped nasal bridge and small chin); delayed teething; a high-pitched voice; thin bones and skin; and decreased sweating (hypohidrosis). it is often caused by mutations in the ghr gene and is inherited in an autosomal recessive manner. treatment focuses on improving growth and includes injections of insulin-like growth factor 1 (igf-1) and a diet with adequate calories. last updated: 11/3/2011

MalaCards: Laron Syndrome, also known as laron-type isolated somatotropin defect, is related to dwarfism and obesity, and has symptoms including skull/cranial anomalies, blue sclerae and flattened nose. An important gene associated with Laron Syndrome is GHR (growth hormone receptor), and among its related pathways are Senescence and Autophagy and Jak-STAT signaling pathway. The compounds estradiol and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, bone and skin, and related mouse phenotypes are renal/urinary system and adipose tissue.

Wikipedia:63 Laron syndrome, or Laron-type dwarfism, is an autosomal recessive disorder characterized by an... more...

Description from OMIM:46 262500

Aliases & Classifications for Laron Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 22GTR, 46OMIM, 20GeneTests, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
laron syndrome:
Inheritance: Autosomal recessive; Prevalence: 1-9/1000000; Age of onset: Neonatal/infancy; Age of death: Normal


Aliases & Descriptions:

laron syndrome 8 42 10 44 48 60
laron-type isolated somatotropin defect 8 22
growth hormone receptor deficiency 42 48
pituitary dwarfism ii 42 20
laron dwarfism 42 46
short stature due to growth hormone resistance 48
growth hormone insensitivity syndrome 42
complete growth hormone insensitivity 48
primary growth hormone insensitivity 48
primary growth hormone resistance 48
laron type pituitary dwarfism i 42
primary gh insensitivity 48
gh receptor deficiency 48
primary gh resistance 48
laron-type dwarfism 48


External Ids:

Disease Ontology8 DOID:9521
OMIM46 262500
MeSH34 D046150
MESH via Orphanet35 D046150
SNOMED-CT56 38196001
ICD10 via Orphanet26 E34.3
SNOMED-CT via Orphanet57 38196001
UMLS via Orphanet61 C0271568

Related Diseases for Laron Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Laron Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1dwarfism30.5GHR, GH1, IGFBP3, IL18R1, IGF1
2obesity30.4GHR, SOAT1, IGFBP2, GH1, IGFBP1, ADIPOQ
3short stature30.1IGF1, STAT5B, GHR, GH1, IGF2, IGFBP1
4diabetic retinopathy30.0IGF1, INS, IGFBP1
5hypothyroidism30.0ADIPOQ, IGFBP3, LSL
6hyperglycemia30.0IGF1, IGFBP1, INS, GH1, LSL, IGFBP3
7hyperandrogenism30.0ADIPOQ, INS, IGF1, IGFBP3, IGFBP1, IGF2
8diabetes mellitus30.0ADIPOQ, INS, IGF1, IGFBP2, IGFBP1, IGFBP3
9adult syndrome10.6
10growth hormone insensitivity with immunodeficiency10.2
11neurofibromatosis10.2
12syringomyelia10.2
13bell's palsy10.1
14thyroid cancer10.1
15thyroiditis10.1
16spinal stenosis10.0
17michelin tire baby syndrome10.0
18multiple myeloma10.0IGF1
19peritonitis10.0IL18R1
20metabolic acidosis10.0IGF1
21werner syndrome10.0IGFBP3
22chronic fatigue syndrome10.0IGFBP1
23psoriasis10.0IL18R1
24gastrinoma10.0GH1
25acute myocardial infarction10.0IGFBP1
26silver-russell syndrome10.0IGF2
27renal osteodystrophy10.0IGFBP1
28sheehan syndrome10.0IGF1
29eating disorder10.0INS
30bulimia nervosa10.0LSL
31hyperprolactinemia10.0IGF1, GH1
32gigantism10.0IGF1, GH1
33rhabdomyosarcoma10.0IGF2
34blindness10.0INS
35hemangiopericytoma10.0IGF2
36pancreatitis10.0INS
37cystic fibrosis10.0INS
38hypoadrenalism10.0GH1
39prolactinoma10.0IGF1, GH1
40insulin-like growth factor i deficiency10.0IGF1, GHR
41severe combined immunodeficiency10.0IL18R1, STAT5B
42nephrotic syndrome10.0IGFBP2
43deficiency anemia10.0LSL
44pituitary gland disease10.0IGF1, GH1
45myeloid leukemia10.0STAT5B, IL18R1
46mental retardation10.0GHR
47leiomyoma10.0IGF2
48empty sella syndrome10.0IGF1, GH1
49gonadal disease10.0IGF1, GH1
50craniopharyngioma10.0GH1, IGF1

Graphical network of the top 20 diseases related to Laron Syndrome:



Diseases related to laron syndrome

Clinical Features for Laron Syndrome

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46OMIM, 48Orphanet
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Clinical features from OMIM:

262500

Clinical synopsis from OMIM:

262500

Symptoms:

48 (show all 31)
  • skull/cranial anomalies
  • blue sclerae
  • flattened nose
  • hypohidrosis/decreased sweating/thermoregulation disorder/heat intolerance
  • hairy patch
  • abnormal cry/voice/phonation disorder/nasal speech
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • osteoarthritis
  • hyperlipidemia/hypercholesterolemia/hypertriglyceridemia
  • premature ageing
  • muscle hypotrophy/atrophy/dystrophy/agenesis/amyotrophy
  • motor deficit/trouble
  • late puberty/hypogonadism/hypogenitalism
  • facial dysmorphism
  • micrognathia/retrognathia/micrognathism/retrognathism
  • nasal atrophy/hypoplasia/arhinia/rudimentary nose
  • complete/partial microdontia
  • anodontia/oligodontia/hypodontia
  • delayed dentition/eruption of teeth/lack of eruption of teeth
  • anomalies of the endocrine glands
  • delayed bone age
  • autosomal recessive inheritance
  • truncal obesity
  • short stature/dwarfism/nanism
  • flat supraorbital ridge
  • elbow anomalies(excluding luxation)
  • short hand/brachydactyly
  • short foot/brachydactyly of toes
  • micropenis/small penis/agenesis
  • hypoglycemia
  • high forehead

Drugs & Therapeutics for Laron Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Laron Syndrome

Drug clinical trials:

Search ClinicalTrials for Laron Syndrome

Search NIH Clinical Center for Laron Syndrome

Search CenterWatch for Laron Syndrome

Genetic Tests for Laron Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Laron Syndrome:

id Genetic test Affiliating Genes
1 Pituitary Dwarfism Ii20 GHR
2 Laron-Type Isolated Somatotropin Defect22

Anatomical Context for Laron Syndrome

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32MalaCards
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MalaCards organs/tissues related to Laron Syndrome:

32
Pituitary, Bone, Skin, Eye, Heart, Brain, Endothelial, Liver

Animal Models for Laron Syndrome or affiliated genes

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36MGI
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Publications for Laron Syndrome

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50PubMed
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Articles related to Laron Syndrome:

(show top 50)    (show all 126)
idTitleAuthorsYear
1
Cochlear hearing loss in patients with Laron syndrome. (21735352)
2012
2
Postprandial hyperglycemia corrected by IGF-I (IncrelexAr) in Laron syndrome. (22986916)
2012
3
The globe and orbit in Laron syndrome. (21757529)
2011
4
Anaesthetic management of a parturient with Laron syndrome. (21840205)
2011
5
Novel growth hormone receptor gene mutation in a patient with Laron syndrome. (20583548)
2010
6
The type specimen (LB1) of Homo floresiensis did not have Laron syndrome. (19294744)
2009
7
Hand size and growth in untreated and IGF-I treated patients with Laron syndrome. (19492579)
2009
8
The obesity of patients with Laron Syndrome is not associated with excessive nutritional intake. (24345535)
2009
9
Total and high molecular weight adiponectin are elevated in patients with Laron syndrome despite marked obesity. (19755405)
2009
10
Nonalcoholic fatty liver in patients with Laron syndrome and GH gene deletion - preliminary report. (18462969)
2008
11
Comparative skeletal features between Homo floresiensis and patients with primary growth hormone insensitivity (Laron Syndrome). (17596857)
2007
12
Foot length before and during insulin-like growth factor-I treatment of children with laron syndrome compared to human growth hormone treatment of children with isolated growth hormone deficiency. (18341092)
2007
13
Growth hormone receptor gene mutations in two Italian patients with Laron Syndrome. (17598975)
2007
14
Long-term IGF-I treatment of children with Laron syndrome increases adiposity. (16442822)
2006
15
Insulinlike growth factor I affects ocular development: a study of untreated and treated patients with Laron syndrome. (16815402)
2006
16
Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity). (16817829)
2006
17
The intellectual capacity of patients with Laron syndrome (LS) differs with various molecular defects of the growth hormone receptor gene. Correlation with CNS abnormalities. (16372230)
2005
18
Laron syndrome (primary growth hormone insensitivity): a unique model to explore the effect of insulin-like growth factor 1 deficiency on human hair. (15178913)
2004
19
Diabetic retinopathy in two patients with congenital IGF-I deficiency (Laron syndrome). (15248828)
2004
20
A novel mutation of the growth hormone receptor gene (GHR) in a Chinese girl with Laron syndrome. (14594180)
2003
21
Laron syndrome abnormalities: spinal stenosis, os odontoideum, degenerative changes of the atlanto-odontoid joint, and small oropharynx. (11950656)
2002
22
GH and epidermal growth factor signaling in normal and Laron syndrome fibroblasts. (12072393)
2002
23
Novel mutation involving the translation initiation codon of the growth hormone receptor gene (GHR) in a patient with Laron syndrome. (12199334)
2002
24
Growth hormone insensitivity (Laron syndrome). (12424436)
2002
25
Serum insulin-like growth factor-I (IGF-I) levels during long-term IGF-I treatment of children and adults with primary GH resistance (Laron syndrome). (10392360)
1999
26
Is the Laron mouse an accurate model of Laron syndrome? (10527674)
1999
27
Development of hyperandrogenism during treatment with insulin-like growth factor-I (IGF-I) in female patients with Laron syndrome. (9509072)
1998
28
Intronic mutation in the growth hormone (GH) receptor gene from a girl with Laron syndrome and extremely high serum GH binding protein: extended phenotypic study in a very large pedigree. (9388817)
1997
29
The growth hormone receptor gene mutation of a Japanese patient with Laron syndrome. (9290257)
1997
30
Muscle force and endurance in untreated and human growth hormone or insulin-like growth factor-I-treated patients with growth hormone deficiency or Laron syndrome. (9030966)
1997
31
Insulin-like growth factor-I raises serum procollagen levels in children and adults with Laron syndrome. (8959080)
1996
32
Laron syndrome: typical and atypical forms. (8853445)
1996
33
A homozygous splice site mutation affecting the intracellular domain of the growth hormone (GH) receptor resulting in Laron syndrome with elevated GH-binding protein. (8626815)
1996
34
Growth hormone insensitivity syndrome (Laron syndrome): main characteristics and effects of IGF1 treatment. (8767171)
1996
35
Carbohydrate metabolism in primary growth hormone resistance (Laron syndrome) before and during insulin-like growth factor-I treatment. (7476303)
1995
36
A single amino acid substitution in the exoplasmic domain of the human growth hormone (GH) receptor confers familial GH resistance (Laron syndrome) with positive GH-binding activity by abolishing receptor homodimerization. (8137822)
1994
37
Laron syndrome: clinical features, molecular pathology and treatment. (7868073)
1994
38
A case of Laron syndrome diagnosed in Slovenia. (7735377)
1994
39
IGF-I treatment of adult patients with Laron syndrome: preliminary results. (7530175)
1994
40
Decreased sweating in seven patients with Laron syndrome. (8370704)
1993
41
Spectrum of growth hormone receptor mutations and associated haplotypes in Laron syndrome. (8504296)
1993
42
Diverse growth hormone receptor gene mutations in Laron syndrome. (8488849)
1993
43
Genetic heterogeneity in Laron syndrome. (8219474)
1993
44
Effects of 17 months treatment using recombinant insulin-like growth factor-I in two children with growth hormone insensitivity (Laron) syndrome. (8334752)
1993
45
Point mutations in the growth hormone receptor gene of patients with Laron syndrome. (1458008)
1992
46
Stimulation of statural growth by recombinant insulin-like growth factor I in a child with growth hormone insensitivity syndrome (Laron type) (1403403)
1992
47
The chronicle of growth hormone receptor deficiency (Laron syndrome). (1458005)
1992
48
Treatment with recombinant human insulin-like growth factor I of children with growth hormone receptor deficiency (Laron syndrome). Kabi Pharmacia Study Group on Insulin-like Growth Factor I Treatment in Growth Hormone Insensitivity Syndromes. (1281024)
1992
49
Defective membrane expression of human growth hormone (GH) receptor causes Laron-type GH insensitivity syndrome. (1719554)
1991
50
Growth hormone receptor deficiency (Laron syndrome): clinical and genetic characteristics. (1785320)
1991

Genetic Variations for Laron Syndrome

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Laron Syndrome:

62 (show all 18)
id Symbol AA change Variation ID SNP ID
1GHRp.Arg89LysVAR_002709
2GHRp.Phe114SerVAR_002710
3GHRp.Val143AlaVAR_002711
4GHRp.Val162AspVAR_002712
5GHRp.Asp170HisVAR_002713
6GHRp.Arg179CysVAR_002714rs121909362
7GHRp.Arg229GlyVAR_002715
8GHRp.Cys440PheVAR_013939rs6182
9GHRp.Cys56SerVAR_018426
10GHRp.Ser58LeuVAR_018427
11GHRp.Trp68ArgVAR_018428
12GHRp.Pro149GlnVAR_018429
13GHRp.Ile171ThrVAR_018431
14GHRp.Gln172ProVAR_018432
15GHRp.Val173GlyVAR_018433
16GHRp.Tyr226CysVAR_018434
17GHRp.Ser244IleVAR_018435
18GHRp.Asp262AsnVAR_018436

Expression for genes affiliated with Laron Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Laron Syndrome

Search GEO for disease gene expression data for Laron Syndrome.

Pathways for genes affiliated with Laron Syndrome

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Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 51QIAGEN, 12EMD Millipore, 52R&D Systems
See all sources

Pathways related to Laron Syndrome according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0INS
29.9GH1, STAT5B
3
Hide members
9.7GH1, GHR, STAT5B
4
Hide members
9.6STAT5B, GHR, IL18R1
5
Development Prolactin receptor signaling
Hide members
9.5INS, GH1, STAT5B
69.4INS, IGFBP1, GHR
7
Hide members
9.4IGF2, IGF1, INS
8
Hide members
9.4INS, IGF1, IGF2
99.4IGF2, IGF1, INS
10
Hide members
9.3ADIPOQ, INS, STAT5B
119.3INS, IGF1, GH1, GHR
12
Hide members
9.1INS, IGF1, IGF2, GH1
139.1STAT5B, GHR, GH1, IGF2, IGF1
14
Hide members
9.1IGF1, IGF2, GH1, GHR, STAT5B
15
Hide members
9.0STAT5B, GH1, IGF2, IGF1, IL18R1
16
Translation Insulin regulation of translation
Hide members
9.0GHR, GH1, IGFBP3, IGF1, INS
178.8STAT5B, GH1, IGF1, INS, ADIPOQ
188.7IGF1, IGFBP2, IGFBP3, IGFBP1, IGF2
198.7IGF1, IGFBP2, IGFBP3, IGFBP1, IGF2
20
Hide members
8.5IGF2, IGFBP1, IGFBP3, IGFBP2, INS
21
Hide members
8.3STAT5B, GHR, GH1, IGF2, IGF1, INS

Compounds for genes affiliated with Laron Syndrome

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Laron Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1estradiol44 11 2412.2IGF2, GHR
2cycloheximide449.7IGFBP1, GHR, IGFBP2
3heparin44 28 11 2412.5GH1, IL18R1, ADIPOQ
4oxandrolone44 1110.4GH1, IGFBP3, IGF1, INS
5ghrp449.4GH1, IGFBP3, GHR, IGF1
6lanreotide44 2810.4IGFBP3, IGFBP1, GH1, GHR, IGF1
7gnrh449.2IGFBP3, IGFBP1, GH1, IGFBP2, GHR
8clomiphene citrate449.1IGF1, INS, GH1, IGFBP3, IGFBP1
9pegvisomant44 1110.1IGFBP3, IGF1, IGFBP1, IGF2, GHR, GH1
10rosiglitazone44 49 28 11 2413.1INS, IGFBP1, LSL
11serine449.0SOAT1, IL18R1, ADIPOQ, STAT5B, GH1
12dexamethasone44 49 28 1111.9INS, IGF2, GH1, SOAT1, ADIPOQ
13ly294002448.8STAT5B, IL18R1, IGFBP2, IGF2, ADIPOQ
14acipimox44 289.8ADIPOQ, LSL, GH1, IGF1, INS
15bromocriptine28 44 1110.7IGF2, GHR, GH1, IGFBP3, IGF1
16fatty acid448.7IGFBP1, GHR, STAT5B, SOAT1, LSL
17tamoxifen44 49 28 1111.7IGF1, LSL, IGF2, IGFBP1, IGFBP2
18progestins448.7GH1, IL18R1, IGFBP3, IGF2, IGFBP1, IGFBP2
19deoxypyridinoline448.6IGFBP3, IGFBP1, IGFBP2, IGF1, LSL, GH1
20progestin448.5IGFBP2, IGF1, ADIPOQ, IGFBP3, IGFBP1, IGF2
21triiodothyronine448.5LSL, GHR, IGF1, GH1, IGFBP1, IGFBP3
22metformin44 49 1110.4GH1, INS, IGFBP1, LSL, IGF1, ADIPOQ
23ribonucleic acid448.3GHR, IGF2, IGF1, GH1, IGFBP3, IGFBP2
24calcitriol44 59 11 2411.2IGF1, IGFBP2, IGFBP3, IGF2, GH1, IL18R1
25vitamin d448.2GHR, GH1, IGF2, ADIPOQ, IGFBP3, IGF1
26dihydrotestosterone44 28 11 2411.2GH1, GHR, IGFBP1, IGFBP3, IGFBP2, IGF1
27prednisolone44 28 1110.1GH1, IGF2, LSL, IGFBP1, IGFBP2, IL18R1
28p002448.0IGFBP1, LSL, IGF2, IGFBP2, ADIPOQ, STAT5B
29thymidine44 249.0IGF2, IGFBP3, GHR, GH1, IGFBP1, IL18R1
30glucose448.0LSL, SOAT1, IGF2, IGFBP3, IGFBP2, IGF1
31acth448.0IGF2, GHR, GH1, IGFBP1, IGFBP3, IGFBP2
32creatinine447.8INS, ADIPOQ, IGF2, LSL, IGF1, IGFBP3
33estrone44 28 11 2410.8LSL, GH1, IGF2, IGFBP1, IGFBP3, IGFBP2
34dehydroepiandrosterone sulfate447.7IGFBP3, IGF1, IGFBP1, LSL, GHR, GH1
35octreotide44 59 28 1110.6IGF2, IGFBP1, IGFBP3, IGF1, INS, ADIPOQ
36hydrocortisone44 2 59 1110.6GH1, IGFBP1, IGFBP2, INS, ADIPOQ, IGF2
37alanine447.6LSL, SOAT1, STAT5B, GH1, IGF2, INS
38rapamycin447.4IL18R1, SOAT1, STAT5B, IGF2, IGFBP1, IGFBP2
39dhea447.3LSL, GH1, IGF2, IGFBP1, IGFBP3, IGFBP2
40vegf447.1IGFBP2, LSL, IL18R1, SOAT1, GH1, IGF2
41androstenedione44 248.1INS, LSL, GHR, GH1, IGF2, IGFBP1
42c-peptide447.1IGFBP1, IGFBP3, IGFBP2, IGF1, INS, ADIPOQ
43thyroxine44 248.1GH1, GHR, LSL, ADIPOQ, INS, IGF1
44steroid447.1LSL, SOAT1, IGFBP2, GHR, GH1, IL18R1
45cholesterol44 28 11 2410.1GHR, IGFBP1, IGFBP3, IGFBP2, LSL, SOAT1
46retinoic acid44 248.0GH1, IGF2, GHR, SOAT1, STAT5B, IGFBP1
47progesterone44 59 28 11 2410.9IL18R1, IGF1, IGFBP2, IGFBP3, IGFBP1, IGF2
48testosterone44 59 11 249.6IGF1, IGFBP1, LSL, SOAT1, GHR, GH1
49phosphatidylinositol446.5IGF2, GHR, STAT5B, SOAT1, LSL, IGFBP1
50arginine446.3GH1, GHR, SOAT1, LSL, IGF2, IGFBP1

GO Terms for genes affiliated with Laron Syndrome

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16Gene Ontology
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Cellular components related to Laron Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor binding protein complexGO:0169429.9IGF1, IGFBP3
2extracellular spaceGO:0056157.2ADIPOQ, GHR, GH1, IGF2, IGFBP1, IGFBP3
3extracellular regionGO:0055767.0GHR, GH1, IGF2, IGFBP1, IGFBP3, IGFBP2

Biological processes related to Laron Syndrome according to GeneCards/GeneDecks:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1allantoin metabolic processGO:00025510.3GHR, STAT5B
2isoleucine metabolic processGO:00654910.3GHR, STAT5B
3creatinine metabolic processGO:04644910.3GHR, STAT5B
4taurine metabolic processGO:01953010.3STAT5B, GHR
5valine metabolic processGO:00657310.3STAT5B, GHR
6citrate metabolic processGO:00610110.3GHR, STAT5B
7growth hormone receptor signaling pathwayGO:06039610.2GHR, GH1
8succinate metabolic processGO:00610510.2STAT5B, GHR
9oxaloacetate metabolic processGO:00610710.2STAT5B, GHR
10creatine metabolic processGO:00660010.1GHR, STAT5B
11positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.1GHR, GH1, IGF1
12regulation of multicellular organism growthGO:04001410.1STAT5B, GHR, IGF1
13JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.1STAT5B, GHR, GH1
14JAK-STAT cascadeGO:00725910.1STAT5B, GHR, GH1
15positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.1GH1, IGFBP3, IGF1
16positive regulation of multicellular organism growthGO:04001810.1STAT5B, GHR, GH1
17positive regulation of glycogen (starch) synthase activityGO:200046710.0ADIPOQ, IGF2
18negative regulation of smooth muscle cell migrationGO:01491210.0IGFBP3, ADIPOQ
19positive regulation of insulin receptor signaling pathwayGO:0466289.9INS, IGF2
20positive regulation of glycolysisGO:0458219.9INS, IGF1
21insulin-like growth factor receptor signaling pathwayGO:0480099.9GHR, IGF1
22regulation of glucose metabolic processGO:0109069.9IGFBP3, ADIPOQ
23negative regulation of gluconeogenesisGO:0457219.9INS, ADIPOQ
24positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.8GH1, IGF1, INS
25cellular response to hormone stimulusGO:0328709.8STAT5B, GHR, IGFBP2
26positive regulation of glycogen biosynthetic processGO:0457259.8INS, IGF1, IGF2
27positive regulation of mitosisGO:0458409.8IGF2, IGF1, INS
28positive regulation of glucose importGO:0463269.7IGF1, INS, ADIPOQ
29positive regulation of protein kinase B signaling cascadeGO:0518979.7IGF2, IGF1, INS
30positive regulation of cellular protein metabolic processGO:0322709.7ADIPOQ, INS
312-oxoglutarate metabolic processGO:0061039.7GHR, STAT5B
32response to glucocorticoid stimulusGO:0513849.6ADIPOQ, IGFBP2, GHR
33response to estradiol stimulusGO:0323559.6STAT5B, GHR, GH1, IGFBP2
34positive regulation of MAPK cascadeGO:0434109.5INS, IGF1, IGFBP3, IGF2
35positive regulation of activated T cell proliferationGO:0421049.5STAT5B, IGF2, IGFBP2, IGF1
36insulin receptor signaling pathwayGO:0082869.3INS, IGFBP1, IGF2
37glucose metabolic processGO:0060069.2ADIPOQ, INS, IGF2
38positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.9ADIPOQ, INS, IGF1, IGF2, GH1, GHR
39cellular protein metabolic processGO:0442678.6IGF2, IGFBP1, IGFBP3, IGFBP2, IGF1, INS

Molecular functions related to Laron Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor bindingGO:0055209.8IGFBP3, IGFBP1
2insulin-like growth factor I bindingGO:0319949.6IGFBP3, IGFBP2
3insulin-like growth factor receptor bindingGO:0051599.5IGF2, IGF1, INS
4insulin receptor bindingGO:0051589.4INS, IGF1, IGF2
5hormone activityGO:0051798.8ADIPOQ, INS, IGF1, IGF2, GH1
6protein bindingGO:0055156.5SOAT1, STAT5B, GHR, GH1, IGF2, IGFBP3

Products for genes affiliated with Laron Syndrome

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  • Antibodies
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Sources for Laron Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet