Laryngeal Cancer malady

Wikipedia: Laryngeal cancer may also be called cancer of the larynx or laryngeal carcinoma. Most laryngeal cancers...⁴⁴ more...

MalaCards: Laryngeal Cancer, also known as laryngeal carcinoma, is related to benign tumors and squamous cell carcinoma. An important gene associated with Laryngeal Cancer is ICK (intestinal cell (MAK-like) kinase), and among its related pathways are Signal transduction AKT signaling and DNA damage ATM/ATR regulation of G1/S checkpoint. The compounds vincristine and glucose have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and nk cells, and related mouse phenotypes are respiratory system and craniofacial.

laryngeal cancer 30 32 laryngeal carcinoma 30

carcinoma of larynx 43

Diseases related to laryngeal cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 871)

id	Related Disease	Score	Top Affiliating Genes
1	benign tumors	30.1	PCNA, BSG, LGALS3, MUC1, MMP11, MMP14
2	squamous cell carcinoma	28.5	SERPINB3, LGALS1, LGALS3, CD44, CDH1, MMP7
3	pharyngitis	26.7	PCNA, NAT1, NAT2, VEGFA, VCAN, BCL2
4	laryngitis	22.5	PCNA, RB1, SERPINB3, SERPINA6, SERPINB2, SERPINA3
5	papilloma	21.6	PCNA, RB1, SERPINB3, SERPINB2, VEGFA, MYCN
6	laryngeal carcinoma	21.1	PCNA, RB1, SERPINB2, BSG, NAT2, VEGFA
7	laryngeal squamous cell carcinoma	20.9	PCNA, RB1, BSG, NAT2, VEGFA, VEGFC
8	retinoblastoma	17.7	PCNA, RB1, SERPINB2, BSG, BRCA1, VEGFA
9	cervicitis	17.3	PCNA, RB1, SERPINB3, SERPINB2, SERPINA3, BSG
10	hypoxia	15.6	PCNA, RB1, BSG, BRCA1, VEGFA, VEGFC
11	carcinoma	14.5	PCNA, RB1, SERPINB3, SERPINA6, SERPINB2, SERPINA3
12	alcoholic pancreatitis	14.1	NAT2, BAK1, GSTM1, GSTP1, GSTT1, ADH1B
13	anaplastic plasmacytoma	14.0	PCNA, MYC, MKI67, IFI27, HSPB1
14	brain cancer	14.0	GSTM1, GSTM3, GSTT1, CYP1A1
15	porphyria cutanea tarda	14.0	GSTM1, GSTT1, ALAD, HPX, CYP1A1, AHR
16	ehlers-danlos syndrome	14.0	XRCC1, GSTM1, GSTP1, GSTT1, ERCC2, TNC
17	inverted papilloma	14.0	PCNA, CDKN1B, MKI67, IFI27
18	cerebrooculofacioskeletal syndrome	13.9	ERCC2, ERCC5, ERCC6
19	hereditary mucosal leukokeratosis	13.9	PCNA, MKI67, GSTM1, IFI27, TGFA
20	variegate porphyria	13.8	CD79A, GSR, GSTM1, GSTT1, ALAD, HPX
21	orolaryngeal cancer	13.8	CDKN2A, GSTM1, OGG1, EPHX1
22	acute myeloid leukemia, adult	13.8	BCL2L1, GSTM1, GSTT1, CYP1A1
23	adenoameloblastoma	13.8	PCNA, SERPINA3, BSG, CDKN1B, MMP2, TERT
24	multiple chemical sensitivity	13.8	NAT1, NAT2, MTHFR, CYP2D6
25	transient cerebral ischemia	13.8	BCL2, XIAP, JUN, GSR, ERCC6, CTSD
26	drug-induced hepatitis	13.7	NAT1, NAT2, GSTM1, GSTT1, CYP2D6, EGFR
27	anaplastic carcinoma	13.7	LGALS1, LGALS3, MUC1, CDH1, NME1
28	osteosarcoma, somatic	13.7	RB1, MYC, CHEK2
29	gastritis	13.7	S100A8, MLH1, GSTT1, TERC, TERT, TIMP3
30	neuroendocrine tumor	13.7	MYCN, RAF1, MKI67, CCNB1, IFI27, TAC1
31	open-angle glaucoma	13.7	GSTM1, GSTT1, CYP1B1, TGFB2
32	lacrimal duct obstruction	13.7	MUC2, MMP3, GSTP1, AMBP, GJA1, TGFB2
33	centrocytic lymphoma	13.7	BCL2, MKI67, CCND1
34	follicular adenoma	13.7	BIRC5, LGALS3, MKI67, STAT3, CP
35	microinvasive gastric cancer	13.7	VEGFC, MUC2, S100A8, CDH1, MLH1, PSG2
36	mutagen sensitivity	13.7	PCNA, NAT2, BRCA1, RAD23B, XRCC1, GSTM1
37	male infertility	13.7	MTHFR, MTR, XRCC1, GSTM1, GSTP1, GSTT1
38	down syndrome	13.6	RB1, SERPINA3, MYC, MYCN, CDC25C, CSF3R
39	pericardial effusion	13.6	MUC1, HIF1A, PSG2, ADA
40	albinism	13.6	NAT1, NAT2, XRCC1, GSR, GSTM1, GSTP1
41	embryonal sarcoma	13.6	SERPINA3, MKI67, TP53, SLPI
42	bronchitis	13.6	F8, CYP1A1, NOD2, TGFB2, TAC1, CP
43	toxic encephalopathy	13.6	BCL2, BAX, JUN, GSR, GSTM1, GSTT1
44	mastitis	13.6	BCL2L1, HP, NOD2, CSF1, SLPI, CP
45	newcastle disease	13.6	BIRC5, LGALS1, LGALS3, BAX, LBR
46	parathyroid carcinoma	13.6	RB1, LGALS3, MKI67, CCND1, TP53, TERT
47	lymphoma, diffuse large cell	13.6	MYC, BCL2, BCL2L1, CD44
48	myoma	13.6	PCNA, GSR, CCND1, ERCC2, TERT, EGFR
49	parkinson's disease	13.6	SERPINA3, NAT2, BAX, MTR, XIAP, GSR
50	dyskeratosis	13.6	XIAP, MKI67, TP53, TERC, TERT, POT1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to laryngeal cancer:

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MGI Mouse Phenotypes related to laryngeal cancer:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.4	ADA, MYCN, BRCA1
2	craniofacial phenotype	MP:0005382	10.2	MYCN, ACD, ACAN, GJA1, CSF1, LBR
3	endocrine/exocrine gland phenotype	MP:0005379	9.4	ACD, GJA1, IFNG, CDC25B, CDC25C, CD40LG
4	hematopoietic system phenotype	MP:0005397	9.1	NOD2, TERC, ERCC6, ERCC5, GJA1, HPX
5	liver/biliary system phenotype	MP:0005370	8.8	ADA, SERPINA6, AHR, HIF1A, ACAN, EGFR
6	behavior/neurological phenotype	MP:0005386	8.4	CP, DCN, TAC1, TACR1, TIMP3, TIMP2
7	renal/urinary system phenotype	MP:0005367	8.4	TGFB2, BCL2, CLDN7, MYCN, BRCA1, SERPINA6
8	normal phenotype	MP:0002873	8.1	ADA, OGG1, STAT3, CD44, CDC25C, CD79A
9	pigmentation phenotype	MP:0001186	8.1	ACD, FAS, CDKN2A, BCL2, MYC, BRCA1
10	hearing/vestibular/ear phenotype	MP:0005377	8.1	EGFR, BAK1, BCL2, MYC, RB1, CDKN1A
11	embryogenesis phenotype	MP:0005380	7.6	MYCN, EGFR, HSP90AB1, CCNA2, XRCC1, BIRC5
12	adipose tissue phenotype	MP:0005375	7.3	EGFR, TERC, TP53, ERCC6, ERCC2, CAPN10
13	no phenotypic analysis	MP:0003012	7.2	CTNNB1, MTHFR, LBR, MUC1, MYC, VEGFA
14	limbs/digits/tail phenotype	MP:0005371	6.6	CSF1, TGFB2, ACD, ACAN, EGFR, CTNNB1
15	immune system phenotype	MP:0005387	6.6	ACAN, EGFR, NOD2, CTSB, CTSD, PTK2
16	nervous system phenotype	MP:0003631	6.5	BAK1, LGALS3, LGALS1, BCL2L1, CLCF1, RAF1
17	reproductive system phenotype	MP:0005389	6.0	NME1, CSF1, MLH1, MMP9, MMP14, CDH1
18	mortality/aging	MP:0010768	5.5	CDH1, CLCF1, RAD23B, MYCN, VEGFC, VEGFA
19	integument phenotype	MP:0010771	5.1	NME1, ERCC5, ERCC2, IFNG, CCND1, FAS
20	growth/size phenotype	MP:0005378	5.0	AHR, HIF1A, ACAN, EGFR, CTSB, CTNNB1
21	skeleton phenotype	MP:0005390	4.8	MMP3, MYC, VCAN, VEGFA, BRCA1, RB1
22	vision/eye phenotype	MP:0005391	4.3	TP53, CDKN2A, CDKN1B, CDKN1A, JUN, MTHFR
23	digestive/alimentary phenotype	MP:0005381	4.0	DCN, TGFB2, TGFB1, TGFA, AHR, HIF1A
24	muscle phenotype	MP:0005369	3.8	DCN, STAT3, TGFB2, TGFB1, TGFA, TIMP3
25	tumorigenesis	MP:0002006	3.7	EPHX1, NME1, OGG1, DCN, STAT3, TGFB1
26	cardiovascular system phenotype	MP:0005385	3.0	HSP90AB1, JUN, XIAP, MUC2, LGALS3, BCL2
27	cellular phenotype	MP:0005384	2.3	POT1, CSF3R, CSF1, OGG1, DCN, STAT3
28	homeostasis/metabolism phenotype	MP:0005376	-0.0	CDKN1A, BCL2L1, BCL2, CLDN7, BIRC5, RAD23B

Articles related to laryngeal cancer:

(show top 50)    (show all 133)

id	Title	Authors	Year	Affiliating Genes
1	Transcriptional activities of histone H3, cyclin D1 a nd claudin 7 encoding genes in laryngeal cancer. (21193919)	Kapral M.... Weglarz L.	2011	CCND1, CLDN7, HIST3H3
2	Polymorphic variants of folate metabolism genes and t he risk of laryngeal cancer. (19649727)	Kruszyna A.8.... JagodziA8ski P.P.	2010	MTR, MTHFD1, MTHFR
3	Low expression of Sp100 in laryngeal cancer: correlat ion with cell differentiation. (20512085)	Li W.... Fu W.	2010	SP100
4	Suppression of S-phase kinase-associated protein 2 in duces apoptosis and inhibits tumor growth in human laryngeal cancer. (20668394)	Liu J.... Ji W.	2010	SKP1
5	Significance of Arg554Lys AHR gene polymorhism an su rvival of in squamous cell carcinoma laryngeal cancer in relation to tobacco sm oking--preliminary study (20301892)	Arndt M.... Szyfter K.	2009	AHR
6	Polymorphisms of CYP1A1 and GSTM1 and laryngeal cancer risk: evidence-based meta-analyses. (19252926)	Zhuo W.L.... Chen Z.T.	2009	CYP1A1, GSTM1
7	The role of p53, PCNA and Ki-67 as outcome predictors in the treatment of laryngeal cancer. (20108544)	Sarafoleanu D.... Sarafoleanu C.	2009	TP53, PCNA
8	Clinical characteristics of laryngeal cancer in BRCA- 1 mutation carriers. (19596949)	Jaworowska E.... LubiA8ski J.	2009	BRCA1
9	Increased expression of telomere-related proteins cor relates with resistance to radiation in human laryngeal cancer cell lines. (19424630)	Tang T.... Liu S.Q.	2009	POT1, ACD
10	The expression of oncogene c-myc and its role on hum an laryngeal cancer]. (20359089)	Long X.... Cui Y.	2009	MYC
11	Analysis of TIMP-1, TIMP-2 and TIMP-3 expression as a prognostic factor of laryngeal cancer progression (18837208)	Pietruszewska W.... Bojanowska-Pozniak K.	2008	TIMP2, TIMP1, TIMP3
12	Stage-related decorin and versican expression in human laryngeal cancer. (18383852)	Stylianou M.... Vynios D.H.	2008	DCN, VCAN
13	Transforming growth factor beta isoforms (TGF-beta1, TGF-beta2, TGF-beta3) messenger RNA expression in laryngeal cancer. (18598833)	Kapral M.... Weglarz L.	2008	TGFB1, TGFB2
14	NK-1 receptor antagonists induce apoptosis and counteract substance P-related mitogenesis in human laryngeal cancer cell line HEp-2. (17906845)	Munoz M.... Esteban F.	2008	TACR1, TAC1
15	CAPN10 alleles modify laryngeal cancer risk in the Spanish population. (17382509)	Esteban F.... Ramirez-Lorca R.	2008	CAPN10
16	Expression and clinical significance of stromelysin-3 in laryngeal cancer (18476627)	Duan S.... Guo Y.	2008	MMP11
17	Focal adhesion kinase and E-cadherin as markers for nodal metastasis in laryngeal cancer. (17309983)	Rodrigo J.P.... Chiara M.D.	2007	CDH1, PTK2
18	Overexpression of human 27 kDa heat shock protein in laryngeal cancer cells confers chemoresistance associated with cell growth delay. (16906418)	Lee J.H.... Lee J.H.	2007	HSPB1
19	Alterations of cell cycle regulating proteins: Rb, p21 and p16 in laryngeal cancer (18546941)	Pietruszewska W.... Kobos J.	2007	RB1, CDKN1A, CDKN2A
20	Cartilage aggrecan undergoes significant compositional and structural alterations during laryngeal cancer. (16574327)	Skandalis S.S.... Theocharis D.A.	2006	ACAN
21	Clinical and molecular prognostic factors in operable laryngeal cancer. (15739081)	Vlachtsis K.... Daniilidis I.	2005	EGFR
22	Cell cycle proteins in laryngeal cancer: role in proliferation and prognosis. (16270530)	Peschos D.... Agnantis N.J.	2005	CCND1, PCNA, MKI67
23	Impairment of MLH1 and CDKN2A in oncogenesis of laryngeal cancer. (15083191)	Sasiadek M.M.... Blin N.	2004	RB1, MLH1, CDKN2A
24	Resistance to apoptosis of HPV 16-infected laryngeal cancer cells is associated with decreased Bak and increased Bcl-2 expression. (15036664)	Du J.... van Hasselt C.A.	2004	BAK1
25	Relationship of matrilysin with invasion, metastasis, and prognosis in laryngeal cancer (15142461)	Sun Y.N.... Li P.	2004	MMP7
26	Relationship between susceptibility and prognosis of laryngeal cancer and genetic polymorphisms in CYP1A1 and GSTM1 (15127559)	Li L.... Lu H.H.	2004	CYP1A1, GSTM1
27	Prognostic significance of the immunoexpression of matrix metalloproteinase MMP2 and its inhibitor TIMP2 in laryngeal cancer. (12640351)	Danilewicz M.... Wagrowska-Danilewicz M.	2003	MMP2, TIMP2
28	Laryngeal cancer risk in Caucasians is associated with alcohol and tobacco consumption but not modified by genetic polymorphisms in class I alcohol dehydrogenases ADH1B and ADH1C, and glutathione-S-transferases GSTM1 and GSTT1. (12668919)	Risch A.... Dietz A.	2003	GSTT1, GSTM1, ADH1B
29	Epigenetic control of E-cadherin (CDH1) by CpG methylation in metastasising laryngeal cancer. (12579297)	Azarschab P.... Blin N.	2003	CDH1
30	Expression of extracellular matrix glycoprotein tenascin in the laryngeal cancer (12669429)	Zhang S.... Hua X.	2002	TNC
31	Expression of MUC1 and MUC2 glycoproteins in laryngeal cancer. (11309050)	Jeannon J.P.... Wilson J.A.	2001	MUC1, MUC2
32	Altered MUC1 and MUC2 glycoprotein expression in laryngeal cancer. (11226957)	Jeannon J.P.... Wilson J.A.	2001	MUC2
33	The expression of vascular endothelial growth factor (VEGF) and VEGF-C in early laryngeal cancer: relationship with radioresistance. (11843932)	Homer J.J.... Stafford N.D.	2001	VEGFA, VEGFC
34	Correlation of p16 mutation and biological behavior in Chinese laryngeal cancer (12541773)	Huang H.... Liu Q.	2001	CDKN2A
35	Assessment of cell proliferation antigen Ki-67, protein p53 related to apoptosis and angiogenesis in laryngeal cancer (10974882)	GryczyA8ski M.... Pietruszewska W.	2000	MKI67
36	p53 analysis of laryngeal cancer in exon 4 to 9. (10953333)	Gottschlich S.... Rudert H.	2000	TP53
37	Evaluation of CD44 adhesion molecule, nm23 gene product expression and intensity of angiogenesis in patients with laryngeal cancer (11265374)	GryczyA8ski M.... Pietruszewska W.	2000	CD44, NME1
38	Antioxidant enzymes activity in patients suffering from laryngeal cancer (10974883)	Gierek T.... Markowski J.	2000	GSR
39	Telomerase activity and expression of its RNA component in laryngeal cancer (12563905)	DU B.D.... Zhang F.L.	2000	TERC
40	Expression of protein p27 is associated with progression and prognosis in laryngeal cancer. (10334237)	Fan G.K.... Saito H.	1999	CSF3R, IFI27
41	Association of arylamine N-acetyltransferases NAT1 and NAT2 genotypes to laryngeal cancer risk. (10208649)	Henning S.... Roots I.	1999	NAT1, NAT2
42	Clinical application of proliferating cell nuclear antigen, oncoprotein p53 and tumor front grading analysis in patients operated on for laryngeal cancer. (10525938)	Morawski K.... Steplewska K.	1999	PCNA
43	Clinical relevance of expression of the CIP/KIP cell-cycle inhibitors p21 and p27 in laryngeal cancer. (10506612)	Pruneri G.... Neri A.	1999	CDKN1A, IFI27
44	Proliferating cell nuclear antigen in laryngeal cancer. (9624390)	Krecicki T.... JeleA8 M.	1998	PCNA
45	p53 mutation as a prognostic marker in advanced laryngeal carcinoma. Department of Veterans Affairs Laryngeal Cancer Cooperative Study Group. (9193221)	Bradford C.R.... Wolf G.T.	1997	TP53
46	Effect of subclinical lead intoxication on laryngeal cancer. (9158246)	Kandiloris D.C.... Adamopoulos G.K.	1997	ALAD
47	Epidermal growth factor receptor expression in laryngeal cancer (9639720)	Song J.... Liu Q.	1996	EGFR
48	Flow cytometric DNA analysis and lysosomal cathepsins B and L in locally advanced laryngeal cancer. Relationship with clinicopathologic parameters and prognostic significance. (8625044)	Russo A.... Leto G.	1995	CTSB
49	Nuclear DNA content, proliferating-cell nuclear antigen (PCNA) and p53 immunostaining in predicting progression of laryngeal cancer in situ lesions. (7903288)	Munck-Wikland E.... Auer G.	1994	TP53, PCNA
50	The raf oncogene is associated with a radiation-resistant human laryngeal cancer. (3616625)	Kasid U.... Mark G.E.	1987	RAF1

Genes related to laryngeal cancer according to GeneCards:

(show top 50)    (show all 131)

id	Symbol	Description	Score	GeneCards Section Context
1	ICK	intestinal cell (MAK-like) kinase	11.0	Aliases & Descriptions
2	IFI27	interferon, alpha-inducible protein 27	11.0	Publications
3	SERPINB3	serpin peptidase inhibitor, clade B (ovalbumin), member 3	11.0
4	BAK1	BCL2-antagonist/killer 1	11.0	Publications
5	ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	11.0	Publications
6	MUC2	mucin 2, oligomeric mucus/gel-forming	11.0	Publications
7	GSTM3	glutathione S-transferase mu 3 (brain)	11.0
8	MMP14	matrix metallopeptidase 14 (membrane-inserted)	11.0	Publications
9	NAT1	N-acetyltransferase 1 (arylamine N-acetyltransferase)	11.0	Publications
10	NME1	NME/NM23 nucleoside diphosphate kinase 1	11.0	Publications
11	PCNA	proliferating cell nuclear antigen	11.0	Publications
12	ERCC2	excision repair cross-complementing rodent repair deficiency, complementation group 2	11.0	Publications
13	PSG2	pregnancy specific beta-1-glycoprotein 2	11.0	Publications
14	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
15	HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	11.0
16	CCNA2	cyclin A2	11.0	Publications
17	XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	11.0	Publications
18	BSG	basigin (Ok blood group)	11.0	Publications
19	CTSD	cathepsin D	11.0	Publications
20	LGALS3	lectin, galactoside-binding, soluble, 3	11.0
21	GSR	glutathione reductase	11.0	Publications
22	CP	ceruloplasmin (ferroxidase)	11.0	Publications
23	SLPI	secretory leukocyte peptidase inhibitor	11.0
24	LGALS1	lectin, galactoside-binding, soluble, 1	11.0
25	EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)	11.0
26	CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	11.0	Publications
27	CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	11.0
28	NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	11.0	Publications
29	HSPB1	heat shock 27kDa protein 1	11.0	Publications
30	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11.0	Publications
31	GSTM1	glutathione S-transferase mu 1	11.0	Publications
32	TERT	telomerase reverse transcriptase	11.0	Publications
33	GSTT1	glutathione S-transferase theta 1	11.0	Publications
34	BCL2L1	BCL2-like 1	11.0
35	JUN	jun proto-oncogene	11.0	Publications
36	GSTP1	glutathione S-transferase pi 1	11.0
37	MIR206	microRNA 206	10.9	Publications
38	MIRLET7A1	microRNA let-7a-1	10.9	Publications
39	CLCF1	cardiotrophin-like cytokine factor 1	10.9	Publications
40	ACD	adrenocortical dysplasia homolog (mouse)	10.9	Publications
41	CLDN7	claudin 7	10.9	Publications
42	HPX	hemopexin	10.9	Publications
43	SPAM1	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	10.9	Publications
44	CAPN10	calpain 10	10.9	Publications
45	HIST3H3	histone cluster 3, H3	10.9	Publications
46	ERCC5	excision repair cross-complementing rodent repair deficiency, complementation group 5	10.9	Publications
47	CDC25B	cell division cycle 25 homolog B (S. pombe)	10.9	Publications
48	ALAD	aminolevulinate dehydratase	10.9	Publications
49	MMP11	matrix metallopeptidase 11 (stromelysin 3)	10.9	Publications
50	ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	10.9	Publications

Pathways related to laryngeal cancer according to GeneDecks:

(show top 50)    (show all 185)

id	Pathway	Score	Top Affiliating Genes
1	Signal transduction AKT signaling10	10.7	HSP90AB1
2	DNA damage ATM/ATR regulation of G1/S checkpoint10	10.5	MYC, CHEK2, CDC25A, CCNA2
3	Transcription P53 signaling pathway10	10.1	TP53, CDKN2A, VEGFA
4	Colorectal cancer20	10.0	MSH2, TGFB2, TGFB1
5	Cell adhesion_Cell-matrix glycoconjugates41	10.0	TIMP2, ACAN, TNC, MMP9, AMBP, VCAN
6	Cell cycle ESR1 regulation of G1/S transition10	10.0	CDKN1A, SKP1, MYC, JUN, CDKN1B, CCND1
7	Cell cycle_ESR1 regulation of G1/S transition41	10.0	SKP1, CCND1, CDC25A, RB1, MYC, JUN
8	Busulfan Pathway, Pharmacodynamics34	9.9	STAT3, GSTP1, GSTM1, MLH1, MSH2, XIAP
9	Activation of Matrix Metalloproteinases38	9.9	TIMP1, MMP11, TIMP2, MMP16, MMP14, MMP9
10	Apoptosis Signaling Pathways37	9.9	TP53, HSP90AB1, HSPB1, FAS, BAK1, BCL2L1
11	Inhibition of Matrix Metalloproteinases36	9.9	TIMP1, TIMP2, MMP7, MMP3, MMP2, MMP16
12	Cell adhesion Cell-matrix glycoconjugates10	9.8	CD44, MUC1, AMBP, TNC, TIMP2, ACAN
13	Akt Signaling36	9.8	CCND1, RAF1, VEGFC, PTK2, TIMP3, CSF1
14	DNA damage_ATM/ATR regulation of G1/S checkpoint41	9.8	TP53, CCND1, PCNA, BRCA1, MYC, CHEK2
15	Signal transduction_AKT signaling41	9.7	BCL2L1, BAX, CDKN1A, MYC, TP53, HSP90AB1
16	Development_Thrombopoetin signaling via JAK-STAT pathway41	9.6	BCL2L1, SERPINA3, CDKN1A, CDKN1B, CRP
17	DNA Repair Mechanisms36	9.5	ERCC5, ERCC2, MSH2, XRCC1, CHEK2, RAD23B
18	Development Thrombopoetin signaling via JAK-STAT pathway10	9.3	SERPINA3, CCND1, CDKN1B, CRP, STAT3, BCL2L1
19	ATM Pathway36	9.3	BRCA1, TP53, CCNB1, CDC25A, CDC25C, CDKN1A
20	Cell adhesion_ECM remodeling41	9.2	TIMP3, EGFR, MMP3, MMP2, MMP16, MMP14
21	Cell adhesion ECM remodeling10	9.2	VCAN, CD44, MMP7, MMP9, EGFR, TIMP1
22	Telomerase Components in Cell Signaling36	9.2	FLT1, TERT, EGFR, TP53, TIMP2, TIMP3
23	G1-S Phase Transition36	9.1	TGFB1, CCND1, CCNA2, CDC25A, TP53, CDKN2A
24	Transcription_P53 signaling pathway41	9.1	FLT1, CTNNB1, RB1, VEGFA, BCL2, CDKN2A
25	Angiogenesis3	9.0	TIMP3, TGFB2, TGFB1, TGFA, TIMP2, TIMP1
26	Cell cycle Regulation of G1/S transition (part 1)10	9.0	TGFB2, TGFB1, CCND1, CCNA2, CDC25A, CDKN2A
27	Cell cycle_Regulation of G1/S transition (part 1)41	9.0	TGFB2, TGFB1, SKP1, CCND1, BRCA1, CHEK2
28	Cell Cycle / Checkpoint Control3	8.9	CCNA2, CDKN1B, CDKN1A, MSH2, XRCC1, CHEK2
29	Cell cycle20	8.8	TGFB2, TGFB1, SKP1, TP53, CCND1, CCNA2
30	Cyclins and Cell Cycle Regulation36	8.8	TGFB2, TGFB1, TP53, CCND1, RAF1, CCNA2
31	Chronic myeloid leukemia20	8.7	MYC, TP53, TGFB2, RAF1, BCL2L1, CDKN1B
32	Breast Cancer Regulation by Stathmin136	8.6	ERBB2, CCNB1, TIMP3, TGFA, RAF1, EGFR
33	p53 Mediated Apoptosis36	8.3	BAX, TGFA, VEGFC, TGFB2, TIMP2, TIMP1
34	Mitochondrial Apoptosis36	8.2	TIMP1, BAX, TGFB2, TGFA, TIMP3, BCL2
35	Cellular Apoptosis Pathway36	8.2	CHEK2, EGFR, BAK1, BAX, CDKN2A, TIMP2
36	ILK Signaling36	8.1	TGFA, TIMP3, TIMP2, TIMP1, EGFR, PTK2
37	Endometrial cancer20	7.9	EGFR, CCND1, MLH1, TP53, MYC, RAF1
38	Development_EGFR signaling pathway41	7.9	EGFR, PTK2, MYC, MMP9, MMP2, JUN
39	EGF Pathway36	7.9	EGFR, CDH1, CTNNB1, ERBB2, JUN, PTK2
40	Prostate cancer20	7.7	CCND1, GSTP1, CDKN1B, BCL2, EGFR, RB1
41	Focal adhesion20	7.7	ERBB2, VEGFC, RAF1, BCL2, XIAP, FLT1
42	ERK Signaling36	7.4	TGFB2, EGFR, HIST3H3, TIMP1, TIMP2, TGFA
43	Bladder cancer20	7.1	CDH1, CDKN2A, CDKN1A, RAF1, MYC, VEGFC
44	Estrogen Pathway36	6.9	BCL2, RAF1, TIMP3, TGFA, TGFB1, TGFB2
45	Colorectal Cancer Metastasis36	6.8	STAT3, TGFB2, TGFB1, EGFR, CTNNB1, TP53
46	MAPK Signaling36	6.7	BCL2, JUN, FLT1, ERBB2, TGFB2, TP53
47	Molecular Mechanisms of Cancer36	6.4	CCND1, CDC25A, CDH1, CDKN2A, CDKN1B, CDKN1A
48	JAK-STAT Pathway36	6.3	STAT3, BRCA1, IFNG, TGFB1, TGFB2, FLT1
49	Pancreatic Adenocarcinoma36	5.6	ERBB2, RB1, VEGFC, RAF1, CCND1, CCNA2
50	Pathways in cancer20	5.3	BAX, BCL2L1, BCL2, BIRC5, MYC, VEGFC

Compounds related to laryngeal cancer according to GeneDecks:

(show top 50)    (show all 529)

id	Compound	Score	Top Affiliating Genes
1	vincristine32 34 9 9	13.4	MYCN, F8, ADA
2	glucose32	10.4	VEGFC, VCAN, LGALS1, BAK1, XIAP, MKI67
3	roscovitine32	10.1	PCNA, BIRC5, BCL2L1, XIAP, CDC25A, CCNB1
4	chi 232	9.8	MTHFR, S100A8, CDH1, MLH1, MKI67, GSTM1
5	hyaluronic acid32 18	10.8	VCAN, MYC, MUC1, CD44, CDH1, MMP3
6	glyceraldehyde 3-phosphate32	9.7	VEGFC, MYCN, BIRC5, LGALS1, LGALS3, MMP14
7	mifepristone32 42 9 9	12.6	SERPINA6, BIRC5, BCL2L1, MUC1, BAX, LBR
8	calcitriol32 42 9 18 9	13.3	RB1, MYC, BAK1, XIAP, S100A8, JUN
9	superoxide32 18	10.2	RB1, SERPINB2, SERPINA3, BIRC5, LGALS1, LGALS3
10	leptomycin b32	9.1	BRCA1, BIRC5, LGALS3, CDKN1A, CDKN1B, CDC25C
11	quercetin32 42 9 18 9	13.1	RAF1, BIRC5, BCL2, BCL2L1, BAK1, BAX
12	estradiol32 9 18 9	12.0	PCNA, RB1, SERPINA6, SERPINA3, BRCA1, VEGFC
13	4-hydroxytamoxifen32	8.7	BRCA1, MYC, JUN, HSPB1, ERBB2, CYP1A1
14	dopamine32 9 18 9	11.7	SERPINA3, MYCN, RAF1, MTHFR, CD79A, CDKN2A
15	silymarin32	8.6	PCNA, VEGFA, BIRC5, JUN, CDC25C, MMP2
16	arginine32	8.6	SERPINA6, SERPINA3, LGALS1, LBR, XRCC1, CD79A
17	camptothecin32 42 9 9	11.5	PCNA, RB1, BRCA1, MYC, BIRC5, BCL2
18	calcium32 9 18 9	11.4	RB1, SERPINB2, SERPINA3, BRCA1, VEGFC, BIRC5
19	betacarotene32	8.4	PCNA, RB1, SERPINA3, NAT2, MTHFR, XRCC1
20	indole-3-carbinol32	8.4	BRCA1, BIRC5, BCL2, BCL2L1, BAX, XIAP
21	mg 13232 42	9.2	PCNA, BRCA1, MYC, MYCN, BIRC5, BCL2L1
22	nitric oxide32 9 18 9	10.9	RB1, SERPINB2, NAT1, NAT2, VEGFC, MYCN
23	lipid32	7.9	RB1, SERPINA6, SERPINB2, SERPINA3, BSG, BRCA1
24	lactacystin32	7.9	BRCA1, MYC, MYCN, RAF1, BIRC5, BCL2
25	agar32	7.8	RB1, BRCA1, MYCN, BIRC5, LGALS1, MUC1
26	cholesterol32 9 18 9	10.7	RB1, SERPINA6, SERPINA3, BSG, NAT2, BIRC5
27	oxygen32 18	8.7	RB1, SERPINA3, BRCA1, BIRC5, BCL2, BCL2L1
28	retinoid32	7.6	MYC, MYCN, BCL2, BCL2L1, LGALS1, BAK1
29	formaldehyde32 18	8.5	PCNA, RB1, LGALS3, MUC1, CD79A, CDKN1B
30	batimastat32 42 9 9	10.4	MMP11, MMP14, MMP16, MMP2, MMP3, MMP7
31	geldanamycin32 9 9	9.3	VEGFA, RAF1, BIRC5, BCL2L1, JUN, CDKN1A
32	wortmannin32 42	8.1	RAF1, BIRC5, BCL2, BCL2L1, LGALS3, CHEK2
33	matrigel32	7.0	RB1, SERPINB2, BSG, VEGFA, VEGFC, BCL2L1
34	celecoxib32 42 34 9 18 9	12.0	PCNA, VEGFA, BIRC5, BCL2, BAK1, BAX
35	suberoylanilide hydroxamic acid32	6.8	MYC, RAF1, BIRC5, BCL2, BCL2L1, BAX
36	lactate32	6.8	PCNA, BSG, MYCN, BIRC5, LGALS3, CD79A
37	folate32	6.4	SERPINA3, NAT1, NAT2, BRCA1, MYC, MUC1
38	estrogen32	6.4	PCNA, SERPINA6, SERPINB2, SERPINA3, BSG, NAT1
39	creatinine32	6.4	PCNA, SERPINA3, MUC1, MTHFR, MTR, XRCC1
40	thymidylate32	6.1	PCNA, RB1, BRCA1, VEGFA, BIRC5, BCL2
41	n acetylcysteine32	6.0	PCNA, RAF1, BIRC5, CHEK2, CD79A, CDKN1A
42	methotrexate32 34 42 9 9	10.0	PCNA, RB1, SERPINA3, NAT2, BRCA1, BIRC5
43	butyrate32	5.9	PCNA, RB1, MYC, RAF1, BIRC5, BCL2
44	pd 98,05932	5.9	RB1, VEGFC, MYC, RAF1, BIRC5, BCL2
45	actinomycin d32	5.9	RB1, SERPINB2, VEGFA, MYC, MYCN, BIRC5
46	docetaxel32 34 9 9	8.9	BRCA1, VEGFA, MYC, RAF1, BIRC5, BCL2
47	retinoic acid32 42 18	6.9	RB1, SERPINB2, BRCA1, VEGFC, MYC, MYCN
48	paraffin32	4.8	PCNA, RB1, SERPINB2, SERPINA3, BRCA1, VEGFA
49	5fluorouracil32	4.2	PCNA, RB1, BRCA1, VEGFA, BIRC5, BCL2
50	genistein32 9 18 9	6.6	PCNA, RB1, BRCA1, VEGFA, MYC, MYCN

Cellular components related to laryngeal cancer according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix	GO:031012	10.3	SLPI, VCAN, LGALS1, LGALS3, MMP14, TNC
2	mitochondrial outer membrane	GO:005741	9.8	BAX, BAK1, BCL2L1, BCL2, RAF1, GJA1
3	Golgi lumen	GO:005796	9.7	DCN, TGFB1, ACAN, MMP16, MMP11, MUC2
4	platelet alpha granule lumen	GO:031093	8.9	TGFB2, VEGFA, VEGFC, F8, TIMP1, TGFB1
5	proteinaceous extracellular matrix	GO:005578	8.8	MMP11, TNC, MMP9, MMP2, LGALS1, MMP3
6	cell surface	GO:009986	8.8	TGFA, VEGFA, LGALS1, CD44, CDH1, HSPB1
7	nucleoplasm	GO:005654	8.7	BRCA1, CDKN2A, CDKN1B, CDKN1A, JUN, XRCC1
8	cytosol	GO:005829	7.3	HSPB1, HSP90AB1, ALAD, ICK, CCND1, CCNB1
9	extracellular region	GO:005576	6.6	SERPINB2, TIMP2, MMP9, MMP7, MMP3, MMP2
10	cytoplasm	GO:005737	5.8	TIMP3, AHRR, AHR, HIF1A, EGFR, NOD2
11	extracellular space	GO:005615	5.8	MMP9, HPX, TNC, CTSB, CTSD, CRP
12	nucleus	GO:005634	4.1	AHR, AHRR, TGFA, TGFB1, GSTP1, STAT3

Biological processes related to laryngeal cancer according to GeneDecks:

(show top 50)    (show all 79)

id	Name	GO ID	Score	Top Affiliating Genes
1	xenobiotic metabolic process	GO:006805	10.7	CYP1A1, CYP1B1, GSTM1, GSTP1, NAT2, CYP2D6
2	nucleotide-excision repair	GO:006289	10.5	ERCC2, PCNA, TP53, ERCC6, ERCC5, RAD23B
3	regulation of mitochondrial membrane permeability	GO:046902	10.4	TP53, BAK1, BCL2L1, BCL2
4	regulation of mitochondrial membrane potential	GO:051881	10.4	BAK1, BCL2, BCL2L1, BAX
5	release of cytochrome c from mitochondria	GO:001836	10.3	JUN, BAX, TP53, BCL2, MYC, BCL2L1
6	activation of pro-apoptotic gene products	GO:008633	10.3	FAS, MYC, BCL2, BAK1, BAX, IFI27
7	G2/M transition of mitotic cell cycle	GO:000086	10.3	CHEK2, CCNA2, CDKN1A, CDC25C, CDC25B, CDC25A
8	base-excision repair	GO:006284	10.2	XRCC1, PCNA, ERCC6, TP53, OGG1
9	response to gamma radiation	GO:010332	10.2	ERCC6, TP53, CHEK2, BAX, BAK1, BCL2
10	response to hydrogen peroxide	GO:042542	10.1	BAK1, HP, BCL2, ADA, JUN
11	regulation of cyclin-dependent protein kinase activity	GO:000079	10.1	CDKN1A, CCNA2, CCNB1, CDC25A, CDC25C, CDKN1B
12	replicative senescence	GO:090399	10.1	CHEK2, TERT, CDKN1A, CDKN2A, TP53
13	response to cytokine stimulus	GO:034097	10.1	TGFB2, TIMP1, CTNNB1, JUN, BCL2L1, SP100
14	negative regulation of neuron apoptotic process	GO:043524	10.1	CLCF1, BCL2L1, JUN, HIF1A, BCL2, TGFA
15	neuron apoptotic process	GO:051402	10.1	TP53, BCL2, FAS, BAX, RB1
16	collagen catabolic process	GO:030574	10.1	MMP11, MMP9, MMP7, MMP2, MMP16, MMP3
17	induction of apoptosis by intracellular signals	GO:008629	10.1	BCL2, BCL2L1, BAK1, XIAP, CDKN1A, MYC
18	response to estrogen stimulus	GO:043627	10.0	TIMP3, CCND1, GSTM3, BCL2, BRCA1, FAS
19	response to toxin	GO:009636	10.0	BAX, CDKN1A, CDH1, FAS, ERCC6, CYP1B1
20	response to organic cyclic compound	GO:014070	10.0	JUN, AHR, STAT3, EPHX1, TIMP3, CTSB
21	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:006978	10.0	SP100, TP53, MUC1, BRCA1
22	extracellular matrix disassembly	GO:022617	10.0	MMP7, MMP11, MMP14, MMP16, MMP2, MMP9
23	positive regulation of B cell proliferation	GO:030890	9.9	CDKN1A, BCL2, CD40LG, ADA, CLCF1
24	G1 phase of mitotic cell cycle	GO:000080	9.9	CCND1, RB1, CDKN2A, CDKN1A, CDKN1B, SKP1
25	aging	GO:007568	9.8	TIMP1, BAK1, TGFB1, TGFB2, DCN, ADA
26	response to ethanol	GO:045471	9.8	TACR1, CTSB, CCND1, STAT3, S100A8, BAK1
27	small molecule metabolic process	GO:044281	9.8	MTHFD1, NME1, ADH1C, ADA, ADH1B, MTHFR
28	anti-apoptosis	GO:006916	9.8	SERPINB2, BCL2, BCL2L1, MUC1, XIAP, CD40LG
29	extracellular matrix organization	GO:030198	9.8	MMP16, TIMP2, LGALS3, MMP11, MMP7, MMP14
30	G1/S transition of mitotic cell cycle	GO:000082	9.7	PCNA, RB1, BCL2, CDKN1A, CCND1, CDKN1B
31	mitotic cell cycle	GO:000278	9.7	CCNA2, CCNB1, BIRC5, SKP1, CCND1, CDKN1A
32	cell cycle checkpoint	GO:000075	9.7	RB1, CHEK2, CDKN1A, CDKN1B, CDKN2A, CDC25C
33	angiogenesis	GO:001525	9.6	VEGFC, PTK2, MMP2, CYP1B1, TGFB2, TGFA
34	response to radiation	GO:009314	9.6	TGFB2, CDC25A, JUN, OGG1, TGFB1, MMP9
35	cellular response to organic cyclic compound	GO:071407	9.5	TGFB1, CTNNB1, CDKN1B, LGALS1, HSP90AB1
36	response to DNA damage stimulus	GO:006974	9.5	BCL2, CCND1, MYC, BRCA1, CHEK2, BAX
37	wound healing	GO:042060	9.1	S100A8, RAF1, ERBB2, DCN, TGFB2, TGFA
38	negative regulation of cell growth	GO:030308	9.0	RB1, BCL2, CDKN1A, TP53, CDKN2A, TGFB2
39	positive regulation of transcription, DNA-dependent	GO:045893	8.8	BRCA1, MYC, CHEK2, JUN, CDKN2A, CDH1
40	negative regulation of cell proliferation	GO:008285	8.5	JUN, CDKN1A, CDKN1B, CDKN2A, GJA1, CTNNB1
41	positive regulation of epithelial cell proliferation	GO:050679	8.4	TGFB1, TGFA, NOD2, ERBB2, TACR1, NME1
42	cell proliferation	GO:008283	8.4	TGFB2, MKI67, STAT3, TGFA, TP53, ERCC2
43	cell cycle arrest	GO:007050	8.4	TGFB1, TP53, IFNG, CDKN2A, CDKN1A, MSH2
44	positive regulation of cell migration	GO:030335	8.2	MMP14, CSF1, EGFR, FLT1, TGFB1, PTK2
45	platelet activation	GO:030168	8.2	F8, PTK2, TGFB1, TGFB2, TIMP1, CD40LG
46	response to hypoxia	GO:001666	8.2	ADA, RAF1, BCL2, XRCC1, MMP9, FAS
47	negative regulation of apoptotic process	GO:043066	8.1	TIMP1, MYC, RAF1, CLCF1, BCL2, VEGFA
48	positive regulation of cell proliferation	GO:008284	8.1	CSF1, TGFB2, TGFB1, TIMP1, VEGFA, MYC
49	apoptotic process	GO:006915	8.0	IFNG, GJA1, ERCC2, MSH2, CDH1, LGALS1
50	response to drug	GO:042493	7.6	VEGFC, FAS, CCND1, IFNG, CTNNB1, TGFA

Molecular functions related to laryngeal cancer according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	BH3 domain binding	GO:051434	10.2	BCL2L1, BCL2, BAX
2	glutathione transferase activity	GO:004364	10.2	GSTM3, GSTM1, GSTT1, GSTP1
3	protein N-terminus binding	GO:047485	9.7	ERCC2, ERCC5, ERCC6, TGFB1, TGFB2, DCN
4	metalloendopeptidase activity	GO:004222	9.7	MMP11, MMP2, MMP9, MMP14, MMP16, MMP3
5	protein kinase binding	GO:019901	9.3	CCND1, TP53, PTK2, NOD2, HIF1A, STAT3
6	transcription factor binding	GO:008134	9.3	STAT3, AHR, HIF1A, CTNNB1, BCL2, RB1
7	double-stranded DNA binding	GO:003690	9.2	MSH2, JUN, CTNNB1, EGFR, ERCC5, MYC
8	protein homodimerization activity	GO:042803	8.4	TGFB2, SP100, TERT, ERCC5, AMBP, GSTM3
9	protein phosphatase binding	GO:019903	8.3	EGFR, CDKN1B, CDH1, ERBB2, CTNNB1
10	enzyme binding	GO:019899	8.3	CCND1, BRCA1, SLPI, TGFB1, BIRC5, TP53
11	identical protein binding	GO:042802	8.1	BAK1, NME1, EGFR, SP100, TP53, ERBB2
12	protein heterodimerization activity	GO:046982	7.2	BAX, TGFB2, VEGFA, MYC, RAF1, BIRC5
13	protein binding	GO:005515	1.4	ADA, IFNA2, F8, HSPB1, HSP90AB1, HPX