MCID: LRY016
MIFTS: 63

Laryngeal Carcinoma malady

Cancer diseases, Oral diseases categories

Summaries for Laryngeal Carcinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Laryngeal cancer may also be called cancer of the larynx or laryngeal carcinoma. Most laryngeal cancers... more...

MalaCards: Laryngeal Carcinoma, also known as carcinoma of larynx, is related to nasopharynx carcinoma and esophageal cancer. An important gene associated with Laryngeal Carcinoma is NME1 (NME/NM23 nucleoside diphosphate kinase 1), and among its related pathways are Validated targets of C-MYC transcriptional activation and CDK-mediated phosphorylation and removal of Cdc6. The compounds vegf and progesterone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, endothelial and thyroid, and related mouse phenotypes are cellular and mortality/aging.

Aliases & Classifications for Laryngeal Carcinoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Oral diseases


Aliases & Descriptions:

laryngeal carcinoma 8 42 10 44
carcinoma of larynx 8 60
laryngeal cancer 42 44
malignant neoplasm of larynx 60
malignant neoplasms 60
cancer of larynx 8


External Ids:

Disease Ontology8 DOID:2600
NCIt39 C4855
ICD1025 C32

Related Diseases for Laryngeal Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Laryngeal Benign Neoplasm family:

laryngeal carcinoma

Diseases related to Laryngeal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 741)
idRelated DiseaseScoreTop Affiliating Genes
1nasopharynx carcinoma30.9GSTT1, TP53, NME1, PCNA, VEGFC
2esophageal cancer30.8TP53, NME1, MMP14, PCNA, VEGFC, IFI27
3oral cavity cancer30.7TP53
4laryngeal squamous cell carcinoma30.6GSTT1, TP53, BIRC5, NME1, EIF4E, PCNA
5squamous cell carcinoma30.6NME1, EIF4E, MKI67, CCND1
6stomach cancer30.6TP53
7hepatocellular carcinoma30.6GSTT1, TP53, ENG, SERPINB5, BIRC5, NME1
8leukemia30.6GSTT1, TP53, ENG, BIRC5, NME1, EIF4E
9parathyroid carcinoma30.5MKI67, CCND1
10acute leukemia30.4GSTT1, BIRC5
11papilloma30.4TP53, ENG, PCNA, BAK1, IFI27
12gallbladder cancer30.4NME1, PCNA, MKI67, IFI27
13osteosarcoma30.4TP53, BIRC5, NME1, MMP14
14thyroid cancer30.3GSTT1, TP53, SERPINB5, VEGFC, CCND1
15brain cancer30.3CP, TP53, BIRC5, MMP14, EIF4E
16prostate cancer30.2GSTT1, SERPINB5, BIRC5, NME1, MMP14, PCNA
17gastrointestinal stromal tumor30.2PCNA, MKI67, IFI27
18neuroblastoma30.2TP53, NME1
19cholangiocarcinoma30.1TP53, EIF4E, VEGFC
20myeloid leukemia30.1BIRC5, NME1
21endometrial carcinoma30.1TP53, SERPINB5, CTSD, IFI27
22breast cancer30.1SERPINB5, CTSD, CTTN, AURKA, IFI27, CCND1
23hepatoblastoma30.1BIRC5
24lung cancer30.1TP53, BIRC5, NME1, MMP14, EIF4G1, PCNA
25ovarian cancer30.0TP53, ENG, SERPINB5, BIRC5, NME1, MMP14
26kidney cancer30.0GSTT1, ENG, BIRC5, NME1, PCNA, MKI67
27burkitt's lymphoma30.0CP, TP53, BIRC5, EIF4E, MKI67, BAK1
28colon cancer30.0TP53, ENG, BIRC5, NME1, MMP14, EIF4E
29bladder carcinoma30.0GSTT1, TP53, SERPINB5, BIRC5, MKI67, AURKA
30keratoacanthoma30.0NME1, PCNA, MKI67, BAK1
31non-hodgkin lymphoma30.0GSTT1, CP, BIRC5, BAK1, CCND1
32multiple myeloma30.0TP53, CCND1
33b-cell chronic lymphocytic leukemia30.0TP53, BIRC5, BAK1, CCND1
34cervical adenocarcinoma30.0NME1, IFI27
35angiosarcoma30.0VEGFC
36chronic myeloid leukemia30.0ENG, BIRC5, NME1, EIF4E
37meningioma30.0PCNA, MKI67
38lung small cell carcinoma30.0GSTT1, TP53, VEGFC, CTSD
39adenocarcinoma29.9GSTT1, TP53, ENG, SERPINB5, BIRC5, NME1
40melanoma29.9GSTT1, CP, TP53, ENG, SERPINB5, BIRC5
41retinoblastoma29.9TP53, BIRC5, NME1, PCNA, MKI67, BAK1
42sarcoma29.9TP53, ENG, SERPINB5, MKI67
43inverted papilloma29.9PCNA, MKI67, IFI27
44pancreatic cancer29.9ENG, SERPINB5, BIRC5, PCNA
45bone carcinoma29.9SERPINB5, MMP14, CTSD
46leiomyosarcoma29.9TP53
47vascular disease29.9TP53, PCNA
48colon adenocarcinoma29.9EIF4E
49cervical cancer29.9GSTT1, TP53, BIRC5, NME1, MMP14, PCNA
50glioblastoma multiforme29.8TP53, ENG, BIRC5, MMP14, EIF4E, PCNA

Graphical network of the top 20 diseases related to Laryngeal Carcinoma:



Diseases related to laryngeal carcinoma

Clinical Features for Laryngeal Carcinoma

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Drugs & Therapeutics for Laryngeal Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Laryngeal Carcinoma

Drug clinical trials:

Search ClinicalTrials for Laryngeal Carcinoma

Search NIH Clinical Center for Laryngeal Carcinoma

Search CenterWatch for Laryngeal Carcinoma

Genetic Tests for Laryngeal Carcinoma

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Anatomical Context for Laryngeal Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Laryngeal Carcinoma:

32
Lymph node, Endothelial, Thyroid, Lung, Skin, Breast, Pituitary, T cells, Colon, Small intestine, Monocytes, Testes, Heart, Bone, Prostate

Animal Models for Laryngeal Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Laryngeal Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.3ENG, TP53, SERPINB5, BIRC5, MMP14, EIF4E
2MP:001076811.2TP53, CCND1, ENG, SERPINB5, BIRC5, NME1
3MP:000538711.0VEGFC, CTSD, CTTN, CCND1, BAK1, PCNA
4MP:000539711.0CCND1, CTSD, BAK1, PCNA, BIRC5, ENG
5MP:000537610.6CTSD, GSTT1, CP, MMP14
6MP:000538010.4CTTN, MMP14, SERPINB5, ENG

Publications for Laryngeal Carcinoma

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50PubMed
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Articles related to Laryngeal Carcinoma:

(show top 50)    (show all 1311)
idTitleAuthorsYear
1
Increased expression of metadherin protein predicts worse disease-free and overall survival in laryngeal squamous cell carcinoma. (23364922)
2013
2
Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma. (23131589)
2013
3
Expression and significance of hypoxia-inducible factor-1I+ and glucose transporter-1 in laryngeal carcinoma. (23255932)
2013
4
Prognostic factors for supraglottic laryngeal carcinoma: Importance of the unfit patient. (22730206)
2013
5
Down-regulation of histone deacetylase 2 induces cell apoptosis and inhibits cell proliferation and migration of laryngeal squamous cell carcinoma cells]. (22932408)
2012
6
Expression of mir-21 and mir-375 in laryngeal squamous cell carcinoma]. (23259291)
2012
7
MicroRNA-34a affects the occurrence of laryngeal squamous cell carcinoma by targeting the antiapoptotic gene survivin. (22246523)
2012
8
C-reactive protein level predicts prognosis in patients with locoregionally advanced laryngeal carcinoma treated with chemoradiotherapy. (22311704)
2012
9
Laryngeal tuberculosis presenting as laryngeal carcinoma. (22755382)
2012
10
The involvement of CHD5 hypermethylation in laryngeal squamous cell carcinoma. (21636313)
2011
11
The role of CD44 and matrix metalloproteinase-9 expression in predicting neck metastasis of supraglottic laryngeal carcinoma. (20434807)
2011
12
Chemoresistance of CD133+ cancer stem cells in laryngeal carcinoma. (21542968)
2011
13
Clinical significance of Stat3 and Cyclin D1 expression in laryngeal squamous cell carcinoma]. (22260073)
2011
14
Detection of PD4, CD44, PCNA protein and its clinical significance in human laryngeal carcinoma]. (21254647)
2010
15
Inhibition of the signal transducers and activators of transcription (STAT) 3 signalling pathway by AG490 in laryngeal carcinoma cells. (21309481)
2010
16
Expression and pathobiological significance of Col I, Col IV and Fn in laryngeal squamous cell carcinomas]. (20359090)
2009
17
Laryngeal squamous cell carcinoma in HIV-positive patients: lack of association with human papillomavirus infection. (19601994)
2009
18
hTERT promoter enhances the radiosensitivity to gene-radiation therapy of human laryngeal carcinoma transplanted in nude mice]. (19173799)
2008
19
Laryngeal carcinoma in nonsmoking patients. (18771070)
2008
20
A case of laryngeal histoplasmosis mimicking carcinoma with a review of the literature. (18655654)
2008
21
Early-stage laryngeal squamous cell carcinoma of the epiglottis treated by endoscopic submucosal dissection. (18709620)
2008
22
Role of siRNA silencing of MMP-2 gene on invasion and growth of laryngeal squamous cell carcinoma. (18437407)
2008
23
Has the degree of contrast enhancement with MR imaging in laryngeal carcinoma added value to anatomic parameters regarding prediction of response to radiation therapy? (17846208)
2007
24
P27 and MIB-1 expression is related to malignancy recurrence in laryngeal carcinoma treated with partial laryngectomy: preliminary results. (17459280)
2007
25
Expression and prognostic significance of cyclooxygenase-2 in supraglottic laryngeal squamous cell carcinomas]. (18330256)
2007
26
Current opinion in diagnosis and treatment of laryngeal carcinoma. (16920269)
2006
27
The immunohistochemical expression of p21WAF1/Cip1 and Proliferating cell nuclear antigen in laryngeal squamous cell carcinomas. (16995968)
2006
28
Results of an organ preservation protocol with induction chemotherapy and radiotherapy in patients with locally advanced laryngeal carcinoma. (14986021)
2005
29
Overexpression of the cytokine osteopontin identifies aggressive laryngeal squamous cell carcinomas and enhances carcinoma cell proliferation and invasiveness. (16299231)
2005
30
Laryngeal sporotrichosis mimicking merkel cell carcinoma recurrence. (15692552)
2005
31
Expression of adrenomedullin in the tissue with laryngeal carcinoma]. (16270874)
2005
32
Expression of vascular endothelial growth factor and its receptors in laryngeal carcinoma cell and its significance]. (16375118)
2005
33
The expression and correlation of eIF4E and VEGF in laryngeal squamous cell carcinoma]. (16124648)
2005
34
Expression of hypoxia inducible factor-1alpha and its relationship to apoptosis and proliferation in human laryngeal squamous cell carcinoma. (15791865)
2004
35
Reactive oxygen species production by blood neutrophils of patients with laryngeal carcinoma and antioxidative enzyme activity in their blood. (15244248)
2004
36
Immunohistochemical analysis of pro- and active-caspase 3 in laryngeal squamous cell carcinoma. (15045586)
2004
37
p63 in laryngeal squamous cell carcinoma: evidence for a role of TA-p63 down-regulation in tumorigenesis and lack of prognostic implications of p63 immunoreactivity. (12379767)
2002
38
Significance of p53 and bcl-2 immunoexpression in the prognosis of laryngeal squamous cell carcinoma. (12526287)
2002
39
Inflammatory cutaneous metastasis from laryngeal carcinoma. (11275809)
2001
40
Prognostic value of the expression of p53 and bcl-2 in patients with laryngeal carcinoma. (11829192)
2001
41
The role of computed tomography in the T classification of laryngeal carcinoma. (11180087)
2001
42
Second primary neoplasms in patients with laryngeal carcinoma. (10983969)
2000
43
Overexpression of cyclin D1 in laryngeal carcinomas]. (11189154)
1998
44
Study of the expression of the epidermal growth factor-receptor in the laryngeal squamous cell carcinoma and the correlation with clinical pathology characteristics]. (9644164)
1997
45
Prediction of occult neck metastases in laryngeal carcinoma: role of proliferating cell nuclear antigen, MIB-1, and E-cadherin immunohistochemical determination. (9816133)
1996
46
Results of surgical salvage for radiation failures of laryngeal carcinoma. (7870440)
1995
47
Re-irradiation of laryngeal carcinoma--techniques and results. (8344846)
1993
48
Interferons and bronchogenic carcinoma in juvenile laryngeal papillomatosis. (6189474)
1983
49
Biological behaviour of laryngeal adenoid cystic carcinoma. Therapeutic considerations. (6312389)
1983
50
Carcinoma of the larynx occurring in a female patient with a congenital laryngeal web. (13201866)
1954

Genetic Variations for Laryngeal Carcinoma

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Expression for genes affiliated with Laryngeal Carcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Laryngeal Carcinoma

Search GEO for disease gene expression data for Laryngeal Carcinoma.

Pathways for genes affiliated with Laryngeal Carcinoma

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Sources:
37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology, 29KEGG, 12EMD Millipore, 52R&D Systems, 51QIAGEN
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Pathways related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7TP53, NME1, EIF4G1, EIF4E, BIRC5
2
Hide members
10.7EIF4G1, CCND1, AURKA, BAK1, PCNA
310.7CTSD, BAK1, PCNA, TP53, SERPINB5
410.7CTSD, BAK1, SERPINB5, BIRC5
510.7BAK1, TP53, CCND1, SERPINB5
610.7CCND1, NME1, PCNA, TP53
710.7TP53, BAK1, AURKA, CCND1
8
Hide members
10.7MKI67, AURKA, PCNA, CCND1
9
Hide members
10.7PCNA, BIRC5, CCND1, TP53
10
Hide members
10.7PCNA, BIRC5, CCND1, TP53
1110.6ENG, SERPINB5, VEGFC
12
Hide members
10.6CCND1, SERPINB5, TP53
1310.6SERPINB5, CTSD, TP53
1410.6NME1, CTTN, CCND1
1510.6TP53, BIRC5, AURKA
1610.6TP53, EIF4E, EIF4G1
1710.6TP53, CCND1, PCNA
1810.6TP53, PCNA, CCND1
19
Hide members
10.6TP53, PCNA, CCND1
20
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
10.6TP53, BAK1, BIRC5
2110.6MMP14, BIRC5
22
Hide members
10.6EIF4G1, EIF4E
23
Hide members
10.5AURKA

Compounds for genes affiliated with Laryngeal Carcinoma

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1vegf4411.7CCND1, PCNA, CP, TP53, ENG, CTSD
2progesterone44 59 28 11 2415.7VEGFC, MKI67, PCNA, EIF4E, EIF4G1, MMP14
3paraffin4411.6TP53, ENG, BIRC5, NME1, MMP14, PCNA
4cisplatin44 49 59 1114.6TP53, BIRC5, CCND1, IFI27, CTSD, BAK1
5oxygen44 2412.5GSTT1, MMP14, EIF4E, MKI67, BAK1, VEGFC
6retinoic acid44 2412.5CCND1, CTSD, VEGFC, MKI67, PCNA, EIF4E
7oligonucleotide4411.5TP53, CCND1, BIRC5, EIF4E, MMP14, NME1
8thymidine44 2412.4PCNA, MKI67, VEGFC, BIRC5, CTSD, IFI27
9p0024411.4BIRC5, SERPINB5, ENG, NME1, MMP14, MKI67
10doxorubicin44 49 1113.4MKI67, ENG, BIRC5, TP53, GSTT1, BAK1
11agar4411.3CCND1, EIF4E, CTSD, NME1, BIRC5, ENG
12testosterone44 59 11 2414.3CTSD, IFI27, CCND1, PCNA, VEGFC, SERPINB5
13steroid4411.3MKI67, GSTT1, SERPINB5, BIRC5, NME1, EIF4E
14pd 98,0594411.3IFI27, BIRC5, EIF4E, CTTN, EIF4G1, MMP14
15ly2940024411.3TP53, BIRC5, MMP14, EIF4G1, EIF4E, VEGFC
16tyrosine4411.3BIRC5, NME1, MMP14, EIF4E, MKI67, BAK1
17paclitaxel44 49 1113.3CCND1, IFI27, AURKA, CTSD, BAK1, BIRC5
18phosphatidylinositol4411.3EIF4G1, EIF4E, BAK1, VEGFC, BIRC5, CTSD
19serine4411.3EIF4E, CTTN, AURKA, CCND1, NME1, MMP14
20threonine4411.3MMP14, EIF4E, MKI67, CTTN, IFI27, AURKA
21mg 13244 5912.2IFI27, CCND1, EIF4E, PCNA, EIF4G1, BIRC5
22lactate4411.2CP, IFI27, CTSD, BIRC5, NME1, MMP14
23alanine4411.2PCNA, BAK1, CTSD, BIRC5, EIF4E, NME1
24dexamethasone44 49 28 1114.2BIRC5, NME1, MMP14, PCNA, BAK1, IFI27
255fluorouracil4411.2CTSD, PCNA, NME1, BIRC5, TP53, MKI67
26dutp4411.2BAK1, TP53, BIRC5, PCNA, MKI67, CCND1
27adpribose4411.2TP53, BIRC5, BAK1, IFI27, CCND1, PCNA
28norcantharidin4411.2IFI27, CCND1, MKI67, BIRC5, PCNA
29tamoxifen44 49 28 1114.1SERPINB5, CTSD, CCND1, MKI67, BIRC5
30thymidylate4411.1CCND1, BIRC5, MKI67, IFI27, PCNA, TP53
31cysteine4411.1ENG, MMP14, CP, PCNA, BAK1, CTSD
32p000014411.1MMP14, MKI67, VEGFC, CCND1, BIRC5
33etoposide44 49 59 1114.1CTSD, EIF4G1, EIF4E, BAK1
34estradiol44 11 2413.1CTSD, BIRC5, VEGFC, BAK1, MKI67
35sulindac44 1112.1CCND1, BIRC5, PCNA, TP53, IFI27
36roscovitine4411.1IFI27, CCND1, PCNA, BIRC5, TP53
37matrigel4411.1CTTN, NME1, SERPINB5, CCND1
38arsenite44 2412.0PCNA, EIF4E, EIF4G1, TP53, BIRC5, CCND1
39trastuzumab44 49 1113.0CCND1, IFI27, CTSD, VEGFC, BIRC5
40chi 24411.0IFI27, NME1, MKI67, GSTT1
41celecoxib44 59 28 49 11 2416.0BIRC5, PCNA, CCND1, MKI67, BAK1
42nitric oxide44 11 2412.9EIF4E, CTSD, VEGFC, NME1, BIRC5, SERPINB5
43nimbolide4410.9BIRC5, PCNA, CCND1
44n acetylcysteine4410.9TP53, CCND1, IFI27, BIRC5, PCNA, EIF4E
45lycopene44 2411.9CP, CCND1, IFI27, PCNA
46crcs4410.8CCND1, NME1, BIRC5, TP53
47ascorbic acid44 2411.8CP, ENG, PCNA, CTSD, GSTT1
48bromodeoxyuridine4410.7MMP14, PCNA, CCND1, MKI67, IFI27
49indole-3-carbinol4410.6CCND1, IFI27, BIRC5, TP53
50p0054410.3SERPINB5, MKI67, ENG

GO Terms for genes affiliated with Laryngeal Carcinoma

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16Gene Ontology
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Cellular components related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582910.7GSTT1, CCND1, AURKA, BAK1, EIF4E, EIF4G1
2eukaryotic translation initiation factor 4F complexGO:01628110.6EIF4G1, EIF4E

Biological processes related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1organ regenerationGO:03110010.7MKI67, BAK1, CCND1
2extracellular matrix disassemblyGO:02261710.6ENG, MMP14, CTSD
3regulation of mitochondrial membrane permeabilityGO:04690210.6TP53, BAK1
4mitotic G1 DNA damage checkpointGO:03157110.5CCND1, TP53
5response to drugGO:04249310.4GSTT1, BAK1, VEGFC, CCND1

Molecular functions related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.3TP53, CCND1, AURKA, CTTN, CTSD, VEGFC
2protein kinase bindingGO:01990110.7AURKA, NME1, TP53, CCND1
3chaperone bindingGO:05108710.6BIRC5, TP53, CP, BAK1
4identical protein bindingGO:04280210.4TP53, BIRC5, NME1, PCNA, BAK1

Products for genes affiliated with Laryngeal Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Laryngeal Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet