MCID: LRY016
MIFTS: 59

Laryngeal Carcinoma malady

Rare diseases, Cancer diseases, Oral diseases categories
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Summaries for Laryngeal Carcinoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 Laryngeal cancer may also be called cancer of the larynx or laryngeal carcinoma. Most laryngeal cancers... more...

MalaCards: Laryngeal Carcinoma, also known as carcinoma of larynx, is related to papilloma and breast cancer. An important gene associated with Laryngeal Carcinoma is NME1 (NME/NM23 nucleoside diphosphate kinase 1), and among its related pathways are Signaling mediated by p38-alpha and p38-beta and Translational Control. The compounds taxane and vitamin-e have been mentioned in the context of this disorder. Affiliated tissues include lymph node, endothelial and thyroid, and related mouse phenotypes are tumorigenesis and embryogenesis.

Aliases & Classifications for Laryngeal Carcinoma

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 58SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Oral diseases


Aliases & Descriptions:

laryngeal carcinoma 8 43 10 45
carcinoma of larynx 8 62
laryngeal cancer 43 45
malignant neoplasm of larynx 62
malignant neoplasms 62
cancer of larynx 8


External Ids:

Disease Ontology8 DOID:2600
NCIt40 C4855
ICD1025 C32

Related Diseases for Laryngeal Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Laryngeal Carcinoma family:

Laryngeal Benign Neoplasm

Diseases related to Laryngeal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma30.6ENG, TP53
2breast cancer30.1AURKA, SERPINB5, CCND1, CTSD
3pancreatic cancer30.0SERPINB5, BIRC5, ENG
4sarcoma30.0TP53, SERPINB5, SERPINB2, ENG
5retinoblastoma29.8TP53, SERPINB2, CCND1, BIRC5, NME1
6lung cancer29.8VEGFC, TP53, MMP14, BIRC5, NME1, EIF4G1
7laryngeal squamous cell carcinoma29.6AURKA, VEGFC, TP53, CCND1, BIRC5, GSTT1
8melanoma29.5VEGFC, TP53, SERPINB5, SERPINB2, CP, MMP14
9adenocarcinoma29.4VEGFC, TP53, SERPINB5, SERPINB2, MMP14, CCND1
10laryngitis11.4
11cervicitis10.5
12hypoxia10.4
13endotheliitis10.4
14laryngeal tuberculosis10.3
15tuberculosis10.3
16verrucous carcinoma10.3
17pharyngitis10.3
18thyroiditis10.3
19epiglottitis10.1
20actinomycosis10.1
21histoplasmosis10.1
22laryngocele10.1
23laryngeal cancer, childhood10.1
24meningioma10.1CTSD, GSTT1
25leukoplakia10.1NME1, GSTT1
26laryngeal small cell carcinoma10.1
27spindle cell carcinoma10.1
28trichinosis10.1
29laryngeal mucoepidermoid carcinoma10.1
30small cell carcinoma10.1
31laryngeal adenoid cystic carcinoma10.1
32neuroblastoma10.1TP53, NME1
33bone carcinoma10.0SERPINB5, MMP14, CTSD
34papillary carcinoma10.0VEGFC, SERPINB5, NME1
35follicular thyroid carcinoma10.0VEGFC, NME1
36intraocular melanoma10.0ENG, NME1, VEGFC
37aneurysm10.0CTSD, ENG, MMP14
38adenosquamous carcinoma10.0NME1, CTSD
39follicular adenoma10.0NME1, MMP14, CP, SERPINB5
40endometriosis10.0ENG, GSTT1, MMP14, SERPINB2
41bladder carcinoma10.0SERPINB2, SERPINB5, TP53
42breast fibroadenoma10.0VEGFC, NME1, CTSD
43rhabdomyosarcoma10.0EIF4E, MMP14, TP53
44hematologic cancer10.0ENG, BIRC5, SERPINB2
45cervical intraepithelial neoplasia10.0VEGFC, BIRC5, NME1
46tongue squamous cell carcinoma10.0CCND1, NME1, EIF4E
47astrocytoma10.0ENG, GSTT1, MMP14, TP53
48atherosclerosis10.0SERPINB2, CP, MMP14, GSTT1
49liver cirrhosis10.0SERPINB2, CP, CTSD
50cholangiocarcinoma10.0EIF4E, TP53, VEGFC

Graphical network of the top 20 diseases related to Laryngeal Carcinoma:



Diseases related to laryngeal carcinoma

Symptoms for Laryngeal Carcinoma

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Drugs & Therapeutics for Laryngeal Carcinoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Laryngeal Carcinoma

Search NIH Clinical Center for Laryngeal Carcinoma

Genetic Tests for Laryngeal Carcinoma

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Anatomical Context for Laryngeal Carcinoma

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33MalaCards
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MalaCards organs/tissues related to Laryngeal Carcinoma:

33
Lymph node, Endothelial, Thyroid, Breast, Skin, Colon, Testes, Lung, Monocytes, Bone, Small intestine, Pituitary

Animal Models for Laryngeal Carcinoma or affiliated genes

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37MGI
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Publications for Laryngeal Carcinoma

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52PubMed
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Articles related to Laryngeal Carcinoma:

(show top 50)    (show all 633)
idTitleAuthorsYear
1
Annexin A1, A2, A4 and A5 play important roles in breast cancer, pancreatic cancer and laryngeal carcinoma, alone and/or synergistically. (23255903)
2013
2
Laryngeal leiomyosarcoma masquerading as laryngeal carcinoma. (23729706)
2013
3
Identification of the PAG1 gene as a novel target of inherent radioresistance in human laryngeal carcinoma cells. (22994656)
2012
4
Survivin and laryngeal carcinoma prognosis: nuclear localization and expression of splice variants. (22416874)
2012
5
Laryngeal actinomycosis mimicking relapse of laryngeal carcinoma in a 67-year-old man. (23035173)
2012
6
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation in laryngeal carcinoma. (22317856)
2012
7
Clinical significance of tumor-associated macrophage infiltration in supraglottic laryngeal carcinoma. (21439250)
2011
8
Significance and relationship between DJ-1 gene and surviving gene expression in laryngeal carcinoma. (21556124)
2011
9
Voice handicap and health-related quality of life after treatment for small laryngeal carcinoma. (20938191)
2011
10
Expression of matrix metalloproteinases (MMP-2 and MMP-9) in recurrent respiratory papillomas and laryngeal carcinoma: clinical and morphological parallels. (21259063)
2011
11
Effects of protein kinase CK2I+ on apoptosis and ultrastructure of laryngeal carcinoma cells]. (21162802)
2010
12
Hsa-miR-34c suppresses growth and invasion of human laryngeal carcinoma cells via targeting c-Met. (20198305)
2010
13
Nutlin-3, the small-molecule inhibitor of MDM2, promotes senescence and radiosensitises laryngeal carcinoma cells harbouring wild-type p53. (20588277)
2010
14
Detection of PD4, CD44, PCNA protein and its clinical significance in human laryngeal carcinoma]. (21254647)
2010
15
Primary laryngeal tuberculosis mimicking laryngeal carcinoma: CT scan features. (20351985)
2010
16
Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma. (19546886)
2009
17
Clinical outcomes of total laryngectomy for laryngeal carcinoma. (20071873)
2009
18
Inhibition of cell proliferation and glucose uptake in human laryngeal carcinoma cells by antisense oligonucleotides against glucose transporter-1. (19441091)
2009
19
Expression and clinical significance of Ang-2 and MMP-7 in laryngeal carcinoma]. (20359117)
2009
20
Suppression of survivin expression by short hairpin RNA induces apoptosis in human laryngeal carcinoma cells. (18391576)
2008
21
Morphological tumor front grading and matrix metalloproteinases type I expression as a prognostic parameter of the presence of lymph node micrometastases in laryngeal carcinoma]. (18552024)
2007
22
Alcohol, smoking and human papillomavirus in laryngeal carcinoma: a Nordic prospective multicenter study. (17486368)
2007
23
Has the degree of contrast enhancement with MR imaging in laryngeal carcinoma added value to anatomic parameters regarding prediction of response to radiation therapy? (17846208)
2007
24
Disseminated histoplasmosis mimicking laryngeal carcinoma from central India--a case report. (17001921)
2006
25
Is laryngopharyngeal reflux an important risk factor in the development of laryngeal carcinoma? (16252124)
2006
26
Impact of patient and professional diagnostic delays on the risk of recurrence in laryngeal carcinoma. (15839868)
2005
27
Results of an organ preservation protocol with induction chemotherapy and radiotherapy in patients with locally advanced laryngeal carcinoma. (14986021)
2005
28
Detection of laryngeal carcinoma and epithelial hyperplastic laryngeal lesions via a rapid-access dysphonia clinic. (15453940)
2004
29
Research of fibronectin, p53 and Ezrin protein with occurrence, progress and prognosis in the primary laryngeal carcinoma by the tissuechip technology]. (15835821)
2004
30
Skin metastasis: an unusual localization from laryngeal carcinoma. (16010110)
2004
31
Glut3 expression in biopsy specimens of laryngeal carcinoma is associated with poor survival. (11889403)
2002
32
The role of gastroesophageal reflux in the pathogenesis of laryngeal carcinoma. (12430127)
2002
33
Ki-67 (MIB1), p53, and Lewis-X (LeuM1) as prognostic factors of recurrence in T1 and T2 laryngeal carcinoma. (10852523)
2000
34
Curative radiotherapy for anterior commissure laryngeal carcinoma. (10685566)
2000
35
nm23-H1 protein expression and its clinical significance in human laryngeal carcinoma]. (11387948)
1999
36
Predictive markers for response to chemotherapy, organ preservation, and survival in patients with advanced laryngeal carcinoma. (10547465)
1999
37
Expression of TGF-beta 1 protein and mRNA and the effect on the tissue remodeling in laryngeal carcinomas. (10628385)
1999
38
FHIT gene is abnormal in laryngeal carcinoma]. (11776620)
1999
39
Expression of MMP-1, TIMP-1, and type I collagen in laryngeal carcinoma. (9758368)
1998
40
Computed tomography of laryngeal carcinoma: technique, imaging findings and implications for radiation therapy. (9828544)
1998
41
Relationship between p53 gene expression and radiation effect in laryngeal carcinoma]. (11189420)
1998
42
Study on HPV infection and p53 protein expression in laryngeal carcinoma]. (10323025)
1997
43
Study of detecting p53 gene of laryngeal carcinoma on paraffin-embedded tissue sections by in situ polymerase chain reaction]. (10073037)
1997
44
An unusual case of laryngeal carcinoma metastasizing to the small intestine. (9231097)
1997
45
Cervical lymph node status and survival in laryngeal carcinoma: prognostic factors. (7661516)
1995
46
Expression of P53 protein in laryngeal carcinoma and its clinical significance]. (8762527)
1995
47
Initial results of glutathione-S-transferase GSTM1 and GSTT1 genotypes and genetic predisposition for laryngeal carcinoma]. (8561822)
1995
48
Technetium-99m-MDP uptake in thyroid cartilage in invasive squamous-cell laryngeal carcinoma. (8014678)
1994
49
Nucleolar organizer regions activity in lymphocytes of patients with laryngeal carcinoma. (8003288)
1993
50
Interdigitating cells in the peritumoral infiltrate of laryngeal carcinomas: an immunocytochemical and ultrastructural study. (1723794)
1991

Variations for Laryngeal Carcinoma

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Expression for genes affiliated with Laryngeal Carcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Laryngeal Carcinoma

Search GEO for disease gene expression data for Laryngeal Carcinoma.

Pathways for genes affiliated with Laryngeal Carcinoma

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Sources:
50PathCards, 38NCBI BioSystems Database, 5Cell Signaling Technology, 12EMD Millipore, 54R&D Systems, 30KEGG, 53QIAGEN, 60Thomson Reuters, 55Reactome
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Pathways related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6TP53, EIF4E
29.5EIF4E, EIF4G1, NME1
39.4NME1, CCND1
49.4ENG, SERPINB5, VEGFC
59.3MMP14, SERPINB2, TP53
69.3CTSD, SERPINB5, TP53
79.3CTSD, SERPINB5, TP53
89.2TP53, EIF4G1, EIF4E
99.2SERPINB5, BIRC5, CTSD
109.1CCND1, TP53
119.1CCND1, TP53
129.1AURKA, TP53, BIRC5
138.9NME1, CCND1, TP53
14
Show member pathways
DNA damage response38
8.9CCND1, SERPINB5, TP53
158.9AURKA, TP53, CCND1
16
Show member pathways
8.9CCND1, TP53, AURKA
178.8ENG, CCND1, TP53
18
Show member pathways
8.7VEGFC, TP53, EIF4G1, EIF4E
19
Show member pathways
8.7VEGFC, TP53, EIF4G1, EIF4E
20
Show member pathways
Signal transduction PTEN pathway60
8.5TP53, CCND1, BIRC5
218.5BIRC5, CCND1, TP53
22
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
8.5AURKA, TP53, CCND1, EIF4G1
238.4EIF4E, EIF4G1, NME1, BIRC5, TP53
248.3VEGFC, TP53, CCND1, EIF4E
25
Show member pathways
8.3VEGFC, TP53, CCND1, EIF4E
26
Show member pathways
8.2AURKA, TP53, CCND1, BIRC5
278.2TP53, MMP14, CCND1, BIRC5
28
Show member pathways
8.0VEGFC, TP53, CCND1, BIRC5
298.0VEGFC, TP53, CCND1, BIRC5

Compounds for genes affiliated with Laryngeal Carcinoma

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Sources:
45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR
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Compounds related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 131)
idCompoundScoreTop Affiliating Genes
1taxane459.2BIRC5, TP53, AURKA
2vitamin-e459.2SERPINB2, CP, BIRC5, GSTT1
3ascorbic acid45 2410.1SERPINB2, CP, GSTT1, ENG, CTSD
4pdtc459.0TP53, SERPINB5, CP, BIRC5
5glyceraldehyde 3-phosphate458.7VEGFC, MMP14, BIRC5, NME1, CTSD
6crcs458.7NME1, BIRC5, CCND1, TP53
7p00001458.6VEGFC, MMP14, CCND1, BIRC5
8actinomycin d458.6EIF4E, BIRC5, MMP14, SERPINB2, TP53
9p002458.5SERPINB5, MMP14, BIRC5, GSTT1, NME1, ENG
10cysteine458.4CP, MMP14, NME1, EIF4G1, EIF4E, ENG
11trastuzumab45 51 1110.4CTSD, BIRC5, CCND1, VEGFC
12lactate458.4CTSD, NME1, BIRC5, MMP14, CP
13egcg458.3TP53, MMP14, CCND1, BIRC5
14pge2458.3VEGFC, SERPINB2, BIRC5, NME1, CTSD
15wortmannin458.3MMP14, CCND1, BIRC5, EIF4G1, EIF4E
16adriamycin458.3TP53, CCND1, BIRC5, CTSD
17matrigel458.2VEGFC, SERPINB5, SERPINB2, MMP14, CCND1, NME1
18phosphoinositide458.2MMP14, CCND1, BIRC5, EIF4G1, EIF4E
19mg 13245 619.2TP53, CCND1, BIRC5, EIF4G1, EIF4E
20dexamethasone45 51 29 1111.2VEGFC, SERPINB2, CP, MMP14, BIRC5, NME1
21arsenite45 249.2TP53, CCND1, BIRC5, EIF4G1, EIF4E
22tamoxifen45 51 29 1111.1TP53, SERPINB5, CCND1, BIRC5, CTSD
23alanine458.1CP, MMP14, BIRC5, NME1, EIF4G1, EIF4E
24h2o2458.1TP53, SERPINB2, CP, BIRC5, EIF4E, CTSD
25nitric oxide45 24 1110.1VEGFC, SERPINB5, SERPINB2, BIRC5, NME1, EIF4E
26etoposide45 51 61 1111.1TP53, BIRC5, GSTT1, NME1, EIF4G1, EIF4E
27paclitaxel45 51 1110.0AURKA, TP53, CCND1, BIRC5, CTSD
28curcumin457.9TP53, MMP14, CCND1, BIRC5
29pd 98,059457.9VEGFC, MMP14, CCND1, BIRC5, EIF4G1, EIF4E
30threonine457.9AURKA, MMP14, CCND1, BIRC5, EIF4E, ENG
31lipid457.9VEGFC, SERPINB5, SERPINB2, CP, MMP14, BIRC5
32doxorubicin45 51 119.9TP53, CCND1, BIRC5, GSTT1, ENG, CTSD
33oxygen45 248.7VEGFC, CP, MMP14, BIRC5, GSTT1, EIF4E
34testosterone45 61 24 1110.7VEGFC, SERPINB5, CP, CCND1, BIRC5, CTSD
35steroid457.6SERPINB5, SERPINB2, CCND1, BIRC5, GSTT1, NME1
36agar457.4CP, MMP14, CCND1, BIRC5, NME1, EIF4E
37thymidine45 248.4VEGFC, TP53, MMP14, CCND1, BIRC5, NME1
38phosphatidylinositol457.4VEGFC, MMP14, CCND1, BIRC5, EIF4G1, EIF4E
39ly294002457.4VEGFC, TP53, MMP14, CCND1, BIRC5, EIF4G1
40calcium45 51 24 1110.3SERPINB2, MMP14, BIRC5, NME1, EIF4G1, EIF4E
41tyrosine457.3VEGFC, SERPINB2, MMP14, CCND1, BIRC5, NME1
42cycloheximide457.2TP53, SERPINB2, MMP14, CCND1, BIRC5, EIF4G1
43cisplatin45 51 61 1110.0TP53, SERPINB5, CCND1, BIRC5, GSTT1, NME1
44oligonucleotide457.0VEGFC, TP53, MMP14, CCND1, BIRC5, GSTT1
45retinoic acid45 247.6VEGFC, TP53, SERPINB2, CP, CCND1, BIRC5
46paraffin456.6VEGFC, TP53, SERPINB5, SERPINB2, MMP14, CCND1
47serine456.1CP, SERPINB2, SERPINB5, TP53, AURKA, MMP14
48progesterone45 29 61 24 119.9SERPINB2, MMP14, CCND1, BIRC5, NME1, EIF4G1
49vegf455.5VEGFC, TP53, SERPINB5, SERPINB2, CP, MMP14
50estrogen455.3SERPINB2, CP, MMP14, CCND1, BIRC5, GSTT1

GO Terms for genes affiliated with Laryngeal Carcinoma

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16Gene Ontology
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Cellular components related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1eukaryotic translation initiation factor 4F complexGO:0162819.7EIF4E, EIF4G1
2spindle microtubuleGO:0058769.6BIRC5, AURKA
3extracellular spaceGO:0056158.2VEGFC, SERPINB5, SERPINB2, CP, ENG, CTSD
4cytoplasmGO:0057377.3TP53, SERPINB5, SERPINB2, MMP14, BIRC5, NME1
5cytosolGO:0058297.1EIF4E, AURKA, TP53, CCND1, BIRC5, GSTT1

Biological processes related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of mitotic cell cycleGO:0459319.5EIF4E, BIRC5
2nuclear-transcribed mRNA poly(A) tail shorteningGO:0002899.5EIF4E, EIF4G1
3extracellular matrix disassemblyGO:0226179.4CTSD, ENG, MMP14
4mitotic G1 DNA damage checkpointGO:0315719.2CCND1, TP53
5response to X-rayGO:0101659.0TP53, CCND1

Molecular functions related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein kinase bindingGO:0199018.6NME1, CCND1, TP53, AURKA
2chaperone bindingGO:0510878.6TP53, CP, BIRC5
3protein bindingGO:0055155.4CTSD, AURKA, VEGFC, TP53, SERPINB5, MMP14

Products for genes affiliated with Laryngeal Carcinoma

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Sources for Laryngeal Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet