MCID: LRY016
MIFTS: 58

Laryngeal Carcinoma malady

Cancer category

Summaries for Laryngeal Carcinoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Laryngeal cancer may also be called cancer of the larynx or laryngeal carcinoma. Most laryngeal cancers... more...

MalaCards: Laryngeal Carcinoma, also known as carcinoma of larynx, is related to nasopharynx carcinoma and squamous cell carcinoma. An important gene associated with Laryngeal Carcinoma is NME1 (NME/NM23 nucleoside diphosphate kinase 1), and among its related pathways are Validated targets of C-MYC transcriptional activation and CDK-mediated phosphorylation and removal of Cdc6. The compounds vegf and progesterone have been mentioned in the context of this disorder. Affiliated tissues include the larynx, and related mouse phenotypes are cellular and mortality/aging.

Disease Ontology:8 A respiratory system cancer that is located in the larynx.

Aliases & Classifications for Laryngeal Carcinoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

laryngeal carcinoma 8 43 10 45
carcinoma of larynx 8 61
laryngeal cancer 43 45
malignant neoplasm of larynx 61
malignant neoplasms 61
cancer of larynx 8
larynx cancer 8


External Ids:

Disease Ontology8 DOID:2600, DOID:2596
NCIt40 C4855, C7484
ICD9CM27 161, 161.9
MeSH35 D007822
ICD1025 C32

Related Diseases for Laryngeal Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Laryngeal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 385)
idRelated DiseaseScoreTop Affiliating Genes
1nasopharynx carcinoma30.8GSTT1, TP53, NME1, PCNA, VEGFC
2squamous cell carcinoma30.7NME1, EIF4E, MKI67, CCND1
3stomach cancer30.5TP53
4acute leukemia30.5GSTT1, BIRC5
5thyroid cancer30.2GSTT1, TP53, SERPINB5, VEGFC, CCND1
6brain cancer30.2CP, TP53, BIRC5, MMP14, EIF4E
7parathyroid carcinoma30.2MKI67, CCND1
8wilms tumor30.1VEGFC
9angiosarcoma30.1VEGFC
10oral cancer30.0GSTT1, TP53, ENG, BIRC5, PCNA, VEGFC
11adenocarcinoma29.9GSTT1, TP53, ENG, SERPINB5, BIRC5, NME1
12basal cell carcinoma29.9GSTT1, TP53, MKI67, BAK1
13bone carcinoma29.9SERPINB5, MMP14, CTSD
14vascular disease29.9TP53, PCNA
15transitional cell carcinoma29.8GSTT1, TP53, BIRC5, NME1, MMP14, PCNA
16gastrointestinal stromal tumor29.8PCNA, MKI67, IFI27
17bladder carcinoma in situ29.8TP53, BIRC5, PCNA, CCND1
18ductal carcinoma in situ29.8TP53, CCND1
19atherosclerosis29.8GSTT1, CP, MMP14, IFI27
20chronic myeloid leukemia29.8ENG, BIRC5, NME1, EIF4E
21tongue cancer10.6
22hypoxia10.4
23n syndrome10.3
24laryngeal tuberculosis10.3
25tuberculosis10.3
26verrucous carcinoma10.3
27larynx verrucous carcinoma10.3
28epiglottis cancer10.3
29acute lymphoblastic leukemia, childhood10.3
30vascular cancer10.3
31intrahepatic gall duct cancer10.3
32cheek mucosa cancer10.2
33tonsil cancer10.2
34malignant neoplasm of short bones of lower limb10.2
35round ligament malignant neoplasm10.2
36brain stem neoplasm10.2
37vulva cancer10.2
38laryngeal small cell carcinoma10.2
39small cell carcinoma10.2
40pancreatic endocrine carcinoma10.1
41spinal meninges cancer10.1
42malignant tumor of undescended testis10.1
43splenic flexure cancer10.1
44pancreatic ductal carcinoma10.1
45mandibular cancer10.1
46broad ligament malignant neoplasm10.1
47chest wall lymphoma10.1
48myositis ossificans10.1
49tonsillar pillar cancer10.1
50main bronchus cancer10.1

Graphical network of the top 20 diseases related to Laryngeal Carcinoma:



Diseases related to laryngeal carcinoma

Clinical Features for Laryngeal Carcinoma

Drugs & Therapeutics for Laryngeal Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Laryngeal Carcinoma

Drug clinical trials:

Search ClinicalTrials for Laryngeal Carcinoma

Search NIH Clinical Center for Laryngeal Carcinoma

Search CenterWatch for Laryngeal Carcinoma

Genetic Tests for Laryngeal Carcinoma

Anatomical Context for Laryngeal Carcinoma

Sources:
14FMA
See all sources

FMA organs/tissues related to Laryngeal Carcinoma:

14
The larynx

Animal Models for Laryngeal Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Laryngeal Carcinoma

Sources:
51PubMed
See all sources

Articles related to Laryngeal Carcinoma:

(show top 50)    (show all 1311)
idTitleAuthorsYear
1
MicroRNA-106b regulates the tumor suppressor RUNX3 in laryngeal carcinoma cells. (23912048)
2013
2
Effect of antisense oligodeoxynucleotides glucose transporter-1 on enhancement of radiosensitivity of laryngeal carcinoma. (23983599)
2013
3
Evaluation of lasersurgery and radiotherapy as treatment modalities in early stage laryngeal carcinoma: tumour outcome and quality of voice. (23568036)
2013
4
Expression and clinical significance of SIAH in laryngeal squamous cell carcinoma. (23397081)
2013
5
Comparison of the Adult Comorbidity Evaluation 27 and the Charlson Comorbidity indices in patients with laryngeal squamous cell carcinoma. (22449728)
2012
6
Decreased expression of SATB2: a novel independent prognostic marker of worse outcome in laryngeal carcinoma patients. (22815795)
2012
7
Elevated content of osteopontin in plasma and tumor tissues of patients with laryngeal and hypopharyngeal carcinoma associated with metastasis and prognosis. (21706367)
2012
8
Expression of "a disintegrin and metalloproteinase-33" (ADAM-33) protein in laryngeal squamous cell carcinoma. (22380618)
2012
9
Vertical partial laryngectomy with temporoparietal free flap reconstruction for recurrent laryngeal squamous cell carcinoma: technique and long-term outcomes. (22652947)
2012
10
Down-regulation of TWIST decreases migration and invasion of laryngeal carcinoma Hep-2 cells by regulating the E-cadherin, N-cadherin expression. (21822911)
2011
11
Duffy antigen receptor for chemokines in laryngeal squamous cell carcinoma as a negative regulator. (21105847)
2011
12
The content of cadmium, cobalt and nickel in laryngeal carcinoma. (22295038)
2011
13
Expression of microtubule-associated protein 1 light chain 3 in laryngeal carcinoma]. (21845828)
2011
14
Study of mRNA expression level and hypermethylation of CHFR promoter in the laryngeal squamous cell carcinoma tissue]. (20942233)
2010
15
Downregulation of RhoB GTPase confers resistance to cisplatin in human laryngeal carcinoma cells. (20303648)
2010
16
The cytoskeleton and immigration of laryngeal squamous carcinoma cell affected by Fascin-1 expression]. (21089665)
2010
17
Inhibition of cell proliferation and glucose uptake in human laryngeal carcinoma cells by antisense oligonucleotides against glucose transporter-1. (19441091)
2009
18
Potential role of Notch1 signaling pathway in laryngeal squamous cell carcinoma cell line Hep-2 involving proliferation inhibition, cell cycle arrest, cell apoptosis, and cell migration. (19724860)
2009
19
Prognostic relevance of CD105-assessed microvessel density in laryngeal carcinoma. (19786216)
2009
20
Outcome of conservation surgery for laryngeal carcinoma: an 8-year trial. (19756681)
2009
21
Laryngeal collision tumour: pleomorphic adenoma and squamous cell carcinoma. (19442350)
2009
22
Oxidative stress in patients with laryngeal carcinoma. (19018112)
2008
23
Study on relationship between intratumoral lymphangiogenesis of laryngeal squamous cell carcinoma and lymphatic metastasis]. (18652308)
2008
24
Swallowing outcomes after radiotherapy for laryngeal carcinoma. (18283161)
2008
25
Laryngeal histoplasmosis as a mimicker of squamous cell carcinoma: imaging and histologic findings. (18225621)
2007
26
Expressions of NF-kappaB p65 in laryngeal carcinoma and normal mucous membrane and its clinical significance]. (17969521)
2007
27
Novel glycoconjugates of diospyrin, a quinonoid plant product: synthesis and evaluation of cytotoxicity against human malignant melanoma (A375) and laryngeal carcinoma (Hep2). (17878970)
2007
28
An immunohistochemical study of cyclin D1 protein expression in laryngeal squamous cell carcinoma. (17573573)
2007
29
Expression of neuropilin-1 in human laryngeal carcinoma and cell lines]. (17017185)
2006
30
TP53 mutations and S-phase fraction but not DNA-ploidy are independent prognostic indicators in laryngeal squamous cell carcinoma. (15965904)
2006
31
Identification of target genes in laryngeal squamous cell carcinoma by high-resolution copy number and gene expression microarray analyses. (16715129)
2006
32
The investigation of STK15 gene amplification and overexpression in laryngeal squamous cell carcinoma]. (16767676)
2006
33
Level IIb lymph node metastasis in laryngeal squamous cell carcinoma. (16467717)
2006
34
Blood reactive oxygen metabolites (ROMs) and total antioxidant status (TAS) in patients with laryngeal squamous cell carcinoma after surgical treatment. (16879077)
2006
35
Impact of patient and professional diagnostic delays on the risk of recurrence in laryngeal carcinoma. (15839868)
2005
36
Expressions and clinical significance of urokinase-type activator (uPA) and uPA receptor (uPAR) in laryngeal squamous cell carcinoma]. (16176001)
2005
37
Advanced laryngeal carcinoma: surgical and non-surgical management options. (15649498)
2005
38
Malignant granular cell tumor in larynx mimicking laryngeal carcinoma. (15239036)
2004
39
Effects of gastroesophageal reflux disease in laryngeal carcinoma. (15373871)
2004
40
Relation between vascular endothelial growth factor expression and clinical pathological character in laryngeal squamous cell carcinoma]. (15510660)
2002
41
Clinical and histopathological correlates of the proliferative activity in squamous cell laryngeal carcinoma. (12201000)
2002
42
Differential expression levels of urokinase-type plasminogen activator and cathepsin D in locally advanced laryngeal squamous cell carcinoma: clinical implications. (11820719)
2001
43
Physical state and expression of human papillomavirus in laryngeal carcinoma and surrounding normal mucosa. (10686022)
2000
44
Loss of heterozygosity and microsatellite instability in laryngeal carcinoma near p16 gene]. (10194257)
1999
45
Expression of MMP-1, TIMP-1, and type I collagen in laryngeal carcinoma. (9758368)
1998
46
Clinical relevance of p53 and bcl-2 protein over-expression in laryngeal squamous-cell carcinoma. (9645348)
1998
47
Serum dihydrotestosterone versus total testosterone values of patients with laryngeal carcinomas and chronic laryngitis]. (8766382)
1996
48
Expression of P53 protein in laryngeal carcinoma and its clinical significance]. (8762527)
1995
49
Expression of epidermal growth factor receptor in laryngeal dysplasia and carcinoma. (2239223)
1990
50
Long-term survival in response to combined chemotherapy and radiotherapy in laryngeal small cell carcinoma. (3028349)
1986

Genetic Variations for Laryngeal Carcinoma

Expression for genes affiliated with Laryngeal Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Laryngeal Carcinoma

Search GEO for disease gene expression data for Laryngeal Carcinoma.

Pathways for genes affiliated with Laryngeal Carcinoma

Sources:
38NCBI BioSystems Database, 54Reactome, 4Cell Signaling Technology, 30KEGG, 12EMD Millipore, 53R&D Systems, 52QIAGEN
See all sources

Pathways related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7TP53, BIRC5, NME1, EIF4G1, EIF4E
2
Hide members
10.7CCND1, AURKA, BAK1, PCNA, EIF4G1
310.7CTSD, BAK1, PCNA, SERPINB5, TP53
410.7CTSD, BAK1, BIRC5, SERPINB5
510.7TP53, SERPINB5, BAK1, CCND1
610.7TP53, NME1, PCNA, CCND1
710.7CCND1, AURKA, BAK1, TP53
8
Hide members
10.7PCNA, MKI67, AURKA, CCND1
9
Hide members
10.7TP53, BIRC5, PCNA, CCND1
10
Hide members
10.7TP53, BIRC5, PCNA, CCND1
1110.6ENG, SERPINB5, VEGFC
12
Hide members
10.6CCND1, SERPINB5, TP53
1310.6TP53, SERPINB5, CTSD
1410.6CCND1, CTTN, NME1
1510.6AURKA, BIRC5, TP53
1610.6EIF4E, EIF4G1, TP53
1710.6TP53, PCNA, CCND1
1810.6CCND1, PCNA, TP53
19
Hide members
10.6CCND1, PCNA, TP53
20
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
10.6TP53, BIRC5, BAK1
2110.6BIRC5, MMP14
22
Hide members
10.6EIF4G1, EIF4E
23
Hide members
10.5AURKA

Compounds for genes affiliated with Laryngeal Carcinoma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1vegf4511.7CCND1, PCNA, CP, TP53, ENG, CTSD
2progesterone45 60 29 11 2415.7VEGFC, MKI67, PCNA, EIF4E, EIF4G1, MMP14
3paraffin4511.6TP53, ENG, BIRC5, NME1, MMP14, PCNA
4cisplatin45 50 60 1114.6TP53, BIRC5, CCND1, IFI27, CTSD, BAK1
5oxygen45 2412.5GSTT1, MMP14, EIF4E, MKI67, BAK1, VEGFC
6retinoic acid45 2412.5CCND1, CTSD, VEGFC, MKI67, PCNA, EIF4E
7oligonucleotide4511.5TP53, CCND1, BIRC5, EIF4E, MMP14, NME1
8thymidine45 2412.4PCNA, MKI67, VEGFC, BIRC5, CTSD, IFI27
9p0024511.4BIRC5, SERPINB5, ENG, NME1, MMP14, MKI67
10doxorubicin45 50 1113.4MKI67, ENG, BIRC5, TP53, GSTT1, BAK1
11agar4511.3CCND1, EIF4E, CTSD, NME1, BIRC5, ENG
12testosterone45 60 11 2414.3CTSD, IFI27, CCND1, PCNA, VEGFC, SERPINB5
13steroid4511.3MKI67, GSTT1, SERPINB5, BIRC5, NME1, EIF4E
14pd 98,0594511.3IFI27, BIRC5, EIF4E, CTTN, EIF4G1, MMP14
15ly2940024511.3TP53, BIRC5, MMP14, EIF4G1, EIF4E, VEGFC
16tyrosine4511.3BIRC5, NME1, MMP14, EIF4E, MKI67, BAK1
17paclitaxel45 50 1113.3CCND1, IFI27, AURKA, CTSD, BAK1, BIRC5
18phosphatidylinositol4511.3EIF4G1, EIF4E, BAK1, VEGFC, BIRC5, CTSD
19serine4511.3EIF4E, CTTN, AURKA, CCND1, NME1, MMP14
20threonine4511.3MMP14, EIF4E, MKI67, CTTN, IFI27, AURKA
21mg 13245 6012.2IFI27, CCND1, EIF4E, PCNA, EIF4G1, BIRC5
22lactate4511.2CP, IFI27, CTSD, BIRC5, NME1, MMP14
23alanine4511.2PCNA, BAK1, CTSD, BIRC5, EIF4E, NME1
24dexamethasone45 50 29 1114.2BIRC5, NME1, MMP14, PCNA, BAK1, IFI27
255fluorouracil4511.2CTSD, PCNA, NME1, BIRC5, TP53, MKI67
26dutp4511.2BAK1, TP53, BIRC5, PCNA, MKI67, CCND1
27adpribose4511.2TP53, BIRC5, BAK1, IFI27, CCND1, PCNA
28norcantharidin4511.2IFI27, CCND1, MKI67, BIRC5, PCNA
29tamoxifen45 50 29 1114.1SERPINB5, CTSD, CCND1, MKI67, BIRC5
30thymidylate4511.1CCND1, BIRC5, MKI67, IFI27, PCNA, TP53
31cysteine4511.1ENG, MMP14, CP, PCNA, BAK1, CTSD
32p000014511.1MMP14, MKI67, VEGFC, CCND1, BIRC5
33etoposide45 50 60 1114.1CTSD, EIF4G1, EIF4E, BAK1
34estradiol45 11 2413.1CTSD, BIRC5, VEGFC, BAK1, MKI67
35sulindac45 1112.1CCND1, BIRC5, PCNA, TP53, IFI27
36roscovitine4511.1IFI27, CCND1, PCNA, BIRC5, TP53
37matrigel4511.1CTTN, NME1, SERPINB5, CCND1
38arsenite45 2412.0PCNA, EIF4E, EIF4G1, TP53, BIRC5, CCND1
39trastuzumab45 50 1113.0CCND1, IFI27, CTSD, VEGFC, BIRC5
40chi 24511.0IFI27, NME1, MKI67, GSTT1
41celecoxib45 60 29 50 11 2416.0BIRC5, PCNA, CCND1, MKI67, BAK1
42nitric oxide45 11 2412.9EIF4E, CTSD, VEGFC, NME1, BIRC5, SERPINB5
43nimbolide4510.9BIRC5, PCNA, CCND1
44n acetylcysteine4510.9TP53, CCND1, IFI27, BIRC5, PCNA, EIF4E
45lycopene45 2411.9CP, CCND1, IFI27, PCNA
46crcs4510.8CCND1, NME1, BIRC5, TP53
47ascorbic acid45 2411.8CP, ENG, PCNA, CTSD, GSTT1
48bromodeoxyuridine4510.7MMP14, PCNA, CCND1, MKI67, IFI27
49indole-3-carbinol4510.6CCND1, IFI27, BIRC5, TP53
50p0054510.3SERPINB5, MKI67, ENG

GO Terms for genes affiliated with Laryngeal Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582910.7GSTT1, CCND1, AURKA, BAK1, EIF4E, EIF4G1
2eukaryotic translation initiation factor 4F complexGO:01628110.6EIF4G1, EIF4E

Biological processes related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1organ regenerationGO:03110010.7MKI67, BAK1, CCND1
2extracellular matrix disassemblyGO:02261710.6ENG, MMP14, CTSD
3regulation of mitochondrial membrane permeabilityGO:04690210.6TP53, BAK1
4mitotic G1 DNA damage checkpointGO:03157110.5CCND1, TP53
5response to drugGO:04249310.4GSTT1, BAK1, VEGFC, CCND1

Molecular functions related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.3TP53, CCND1, AURKA, CTTN, CTSD, VEGFC
2protein kinase bindingGO:01990110.7TP53, NME1, AURKA, CCND1
3chaperone bindingGO:05108710.6BAK1, BIRC5, TP53, CP
4identical protein bindingGO:04280210.4BAK1, PCNA, NME1, BIRC5, TP53

Products for genes affiliated with Laryngeal Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Laryngeal Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet