MCID: LRY016
MIFTS: 51

Laryngeal Carcinoma malady

Rare diseases, Cancer diseases, Oral diseases categories

Summaries for Laryngeal Carcinoma

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Wikipedia:63 Laryngeal cancer, also known as cancer of the larynx or laryngeal carcinoma, are mostly squamous cell... more...

MalaCards based summary: Laryngeal Carcinoma, also known as carcinoma of larynx, is related to papilloma and pancreatic cancer. An important gene associated with Laryngeal Carcinoma is NME1 (NME/NM23 nucleoside diphosphate kinase 1), and among its related pathways are Signaling mediated by p38-alpha and p38-beta and Translational Control. The compounds taxane and vitamin-e have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and endothelial, and related mouse phenotypes are tumorigenesis and embryogenesis.

Disease Ontology:9 A larynx cancer that has material basis in epithelial cells.

Aliases & Classifications for Laryngeal Carcinoma

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Laryngeal Carcinoma, Aliases & Descriptions:

Name: Laryngeal Carcinoma 9 41 11 43
Carcinoma of Larynx 9 60
Laryngeal Cancer 41 43
 
Malignant Neoplasm of Larynx 60
Cancer of Larynx 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Oral diseases


External Ids:

Disease Ontology9 DOID:2600
NCIt38 C4855
ICD1025 C32

Related Diseases for Laryngeal Carcinoma

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Diseases in the Laryngeal Carcinoma family:

Laryngeal Benign Neoplasm

Diseases related to Laryngeal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma30.9ENG, TP53
2pancreatic cancer30.1SERPINB5, BIRC5, ENG
3sarcoma30.0TP53, SERPINB5, SERPINB2, ENG
4breast cancer30.0AURKA, SERPINB5, CCND1, CTSD
5retinoblastoma29.3TP53, SERPINB2, CCND1, BIRC5, NME1
6lung cancer29.2VEGFC, TP53, CCND1, BIRC5, NME1
7laryngeal squamous cell carcinoma28.7AURKA, VEGFC, TP53, CCND1, BIRC5, GSTT1
8melanoma27.8VEGFC, TP53, SERPINB5, SERPINB2, CP, MMP14
9adenocarcinoma27.8VEGFC, TP53, SERPINB5, SERPINB2, MMP14, CCND1
10laryngitis11.4
11cervicitis10.5
12hypoxia10.4
13endotheliitis10.4
14laryngeal tuberculosis10.3
15pharyngitis10.3
16tuberculosis10.3
17meningioma, familial10.3CTSD, GSTT1
18leukoplakia10.3NME1, GSTT1
19verrucous carcinoma10.3
20thyroiditis10.3
21neuroblastoma10.2TP53, NME1
22laryngeal cancer, childhood10.2
23bone cancer10.2SERPINB5, MMP14, CTSD
24papillary carcinoma10.2VEGFC, SERPINB5, NME1
25thyroid carcinoma, follicular10.2VEGFC, NME1
26uveal melanoma10.2ENG, NME1, VEGFC
27aneurysm10.2CTSD, ENG, MMP14
28adenosquamous carcinoma10.2NME1, CTSD
29follicular adenoma10.1NME1, MMP14, CP, SERPINB5
30gastroesophageal reflux10.1
31epiglottitis10.1
32actinomycosis10.1
33histoplasmosis10.1
34laryngocele10.1
35endometriosis10.1ENG, GSTT1, MMP14, SERPINB2
36bladder cancer, somatic10.1SERPINB2, SERPINB5, TP53
37breast ductal carcinoma10.1CTSD, NME1, TP53
38breast fibroadenoma10.1VEGFC, NME1, CTSD
39laryngeal small cell carcinoma10.1
40spindle cell carcinoma10.1
41trichinosis10.1
42laryngeal mucoepidermoid carcinoma10.1
43small cell carcinoma10.1
44laryngeal adenoid cystic carcinoma10.1
45rhabdomyosarcoma10.1EIF4E, MMP14, TP53
46hematologic cancer10.0ENG, BIRC5, SERPINB2
47cervical intraepithelial neoplasia10.0VEGFC, BIRC5, NME1
48tongue squamous cell carcinoma10.0CCND1, NME1, EIF4E
49astrocytoma10.0ENG, GSTT1, MMP14, TP53
50atherosclerosis10.0SERPINB2, CP, MMP14, GSTT1

Graphical network of the top 20 diseases related to Laryngeal Carcinoma:



Diseases related to laryngeal carcinoma

Symptoms for Laryngeal Carcinoma

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Drugs & Therapeutics for Laryngeal Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Laryngeal Carcinoma

Search NIH Clinical Center for Laryngeal Carcinoma

Genetic Tests for Laryngeal Carcinoma

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Anatomical Context for Laryngeal Carcinoma

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MalaCards organs/tissues related to Laryngeal Carcinoma:

31
Skin, Lymph node, Endothelial, Thyroid, Breast, Bone, Small intestine, Colon, Lung, Testes, Monocytes, Pituitary, Neutrophil

Animal Models for Laryngeal Carcinoma or affiliated genes

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Publications for Laryngeal Carcinoma

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Articles related to Laryngeal Carcinoma:

(show top 50)    (show all 670)
idTitleAuthorsYear
1
Expression and significance of glucose transporter-1, P-glycoprotein, multidrug resistance-associated protein and glutathione S-transferase-I8 in laryngeal carcinoma. (25621055)
2015
2
Metastatic laryngeal carcinoma mimicking eruptive keratoacanthomas: report of keratoacanthoma-like cutaneous metastases in a radiation port. (25244165)
2014
3
Bilateral pneumothoraces in a patient with laryngeal carcinoma following tracheostomy for stridor. (25183804)
2014
4
Tea intake and risk of oral, pharyngeal, and laryngeal carcinoma: a meta-analysis. (25363316)
2014
5
Elderly patients at higher risk of laryngeal carcinoma recurrence could be identified by a panel of two biomarkers (nm23-H1 and CD105) and pN+ status. (25280747)
2014
6
Annexin A1, A2, A4 and A5 play important roles in breast cancer, pancreatic cancer and laryngeal carcinoma, alone and/or synergistically. (23255903)
2013
7
Identification of the PAG1 gene as a novel target of inherent radioresistance in human laryngeal carcinoma cells. (22994656)
2012
8
Survivin and laryngeal carcinoma prognosis: nuclear localization and expression of splice variants. (22416874)
2012
9
Laryngeal actinomycosis mimicking relapse of laryngeal carcinoma in a 67-year-old man. (23035173)
2012
10
Clinical significance of tumor-associated macrophage infiltration in supraglottic laryngeal carcinoma. (21439250)
2011
11
Significance and relationship between DJ-1 gene and surviving gene expression in laryngeal carcinoma. (21556124)
2011
12
Voice handicap and health-related quality of life after treatment for small laryngeal carcinoma. (20938191)
2011
13
Expression of matrix metalloproteinases (MMP-2 and MMP-9) in recurrent respiratory papillomas and laryngeal carcinoma: clinical and morphological parallels. (21259063)
2011
14
Effects of protein kinase CK2I+ on apoptosis and ultrastructure of laryngeal carcinoma cells]. (21162802)
2010
15
Hsa-miR-34c suppresses growth and invasion of human laryngeal carcinoma cells via targeting c-Met. (20198305)
2010
16
Nutlin-3, the small-molecule inhibitor of MDM2, promotes senescence and radiosensitises laryngeal carcinoma cells harbouring wild-type p53. (20588277)
2010
17
Detection of PD4, CD44, PCNA protein and its clinical significance in human laryngeal carcinoma]. (21254647)
2010
18
Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma. (19546886)
2009
19
Clinical outcomes of total laryngectomy for laryngeal carcinoma. (20071873)
2009
20
Inhibition of cell proliferation and glucose uptake in human laryngeal carcinoma cells by antisense oligonucleotides against glucose transporter-1. (19441091)
2009
21
Expression and clinical significance of Ang-2 and MMP-7 in laryngeal carcinoma]. (20359117)
2009
22
Suppression of survivin expression by short hairpin RNA induces apoptosis in human laryngeal carcinoma cells. (18391576)
2008
23
Morphological tumor front grading and matrix metalloproteinases type I expression as a prognostic parameter of the presence of lymph node micrometastases in laryngeal carcinoma]. (18552024)
2007
24
Alcohol, smoking and human papillomavirus in laryngeal carcinoma: a Nordic prospective multicenter study. (17486368)
2007
25
Has the degree of contrast enhancement with MR imaging in laryngeal carcinoma added value to anatomic parameters regarding prediction of response to radiation therapy? (17846208)
2007
26
Disseminated histoplasmosis mimicking laryngeal carcinoma from central India--a case report. (17001921)
2006
27
Is laryngopharyngeal reflux an important risk factor in the development of laryngeal carcinoma? (16252124)
2006
28
Impact of patient and professional diagnostic delays on the risk of recurrence in laryngeal carcinoma. (15839868)
2005
29
Results of an organ preservation protocol with induction chemotherapy and radiotherapy in patients with locally advanced laryngeal carcinoma. (14986021)
2005
30
Research of fibronectin, p53 and Ezrin protein with occurrence, progress and prognosis in the primary laryngeal carcinoma by the tissuechip technology]. (15835821)
2004
31
Skin metastasis: an unusual localization from laryngeal carcinoma. (16010110)
2004
32
Glut3 expression in biopsy specimens of laryngeal carcinoma is associated with poor survival. (11889403)
2002
33
The role of gastroesophageal reflux in the pathogenesis of laryngeal carcinoma. (12430127)
2002
34
Ki-67 (MIB1), p53, and Lewis-X (LeuM1) as prognostic factors of recurrence in T1 and T2 laryngeal carcinoma. (10852523)
2000
35
Curative radiotherapy for anterior commissure laryngeal carcinoma. (10685566)
2000
36
nm23-H1 protein expression and its clinical significance in human laryngeal carcinoma]. (11387948)
1999
37
Predictive markers for response to chemotherapy, organ preservation, and survival in patients with advanced laryngeal carcinoma. (10547465)
1999
38
Expression of TGF-beta 1 protein and mRNA and the effect on the tissue remodeling in laryngeal carcinomas. (10628385)
1999
39
Expression of MMP-1, TIMP-1, and type I collagen in laryngeal carcinoma. (9758368)
1998
40
Computed tomography of laryngeal carcinoma: technique, imaging findings and implications for radiation therapy. (9828544)
1998
41
Relationship between p53 gene expression and radiation effect in laryngeal carcinoma]. (11189420)
1998
42
Study on HPV infection and p53 protein expression in laryngeal carcinoma]. (10323025)
1997
43
Study of detecting p53 gene of laryngeal carcinoma on paraffin-embedded tissue sections by in situ polymerase chain reaction]. (10073037)
1997
44
An unusual case of laryngeal carcinoma metastasizing to the small intestine. (9231097)
1997
45
Cervical lymph node status and survival in laryngeal carcinoma: prognostic factors. (7661516)
1995
46
Expression of P53 protein in laryngeal carcinoma and its clinical significance]. (8762527)
1995
47
Initial results of glutathione-S-transferase GSTM1 and GSTT1 genotypes and genetic predisposition for laryngeal carcinoma]. (8561822)
1995
48
Technetium-99m-MDP uptake in thyroid cartilage in invasive squamous-cell laryngeal carcinoma. (8014678)
1994
49
Nucleolar organizer regions activity in lymphocytes of patients with laryngeal carcinoma. (8003288)
1993
50
Interdigitating cells in the peritumoral infiltrate of laryngeal carcinomas: an immunocytochemical and ultrastructural study. (1723794)
1991

Variations for Laryngeal Carcinoma

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Cosmic variations for Laryngeal Carcinoma:

7
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
110808TP53upper aerodigestive tract,larynx,carcinoma,squamous cell carcinoma1

Expression for genes affiliated with Laryngeal Carcinoma

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Search GEO for disease gene expression data for Laryngeal Carcinoma.

Pathways for genes affiliated with Laryngeal Carcinoma

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Pathways related to Laryngeal Carcinoma according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6TP53, EIF4E
29.5EIF4E, EIF4G1, NME1
39.4NME1, CCND1
49.4ENG, SERPINB5, VEGFC
59.3MMP14, SERPINB2, TP53
69.3CTSD, SERPINB5, TP53
79.2TP53, EIF4G1, EIF4E
89.2SERPINB5, BIRC5, CTSD
99.1CCND1, TP53
109.1CCND1, TP53
119.1AURKA, TP53, BIRC5
128.9NME1, CCND1, TP53
13
Show member pathways
DNA damage response36
8.9CCND1, SERPINB5, TP53
148.9AURKA, TP53, CCND1
15
Show member pathways
8.9CCND1, TP53, AURKA
168.8ENG, CCND1, TP53
17
Show member pathways
8.7VEGFC, TP53, EIF4G1, EIF4E
18
Show member pathways
8.7VEGFC, TP53, EIF4G1, EIF4E
19
Show member pathways
Signal transduction PTEN pathway58
8.5TP53, CCND1, BIRC5
208.5BIRC5, CCND1, TP53
21
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
8.5AURKA, TP53, CCND1, EIF4G1
228.4EIF4E, EIF4G1, NME1, BIRC5, TP53
238.3VEGFC, TP53, CCND1, EIF4E
24
Show member pathways
8.3VEGFC, TP53, CCND1, EIF4E
25
Show member pathways
8.2AURKA, TP53, CCND1, BIRC5
268.2TP53, MMP14, CCND1, BIRC5
27
Show member pathways
8.0VEGFC, TP53, CCND1, BIRC5
288.0VEGFC, TP53, CCND1, BIRC5

Compounds for genes affiliated with Laryngeal Carcinoma

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Compounds related to Laryngeal Carcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 131)
idCompoundScoreTop Affiliating Genes
1taxane439.2BIRC5, TP53, AURKA
2vitamin-e439.2SERPINB2, CP, BIRC5, GSTT1
3ascorbic acid43 2410.1SERPINB2, CP, GSTT1, ENG, CTSD
4pdtc439.0TP53, SERPINB5, CP, BIRC5
5glyceraldehyde 3-phosphate438.7VEGFC, MMP14, BIRC5, NME1, CTSD
6crcs438.7NME1, BIRC5, CCND1, TP53
7p00001438.6VEGFC, MMP14, CCND1, BIRC5
8actinomycin d438.6EIF4E, BIRC5, MMP14, SERPINB2, TP53
9p002438.5SERPINB5, MMP14, BIRC5, GSTT1, NME1, ENG
10cysteine438.4CP, MMP14, NME1, EIF4G1, EIF4E, ENG
11trastuzumab43 49 1210.4CTSD, BIRC5, CCND1, VEGFC
12lactate438.4CTSD, NME1, BIRC5, MMP14, CP
13egcg438.3TP53, MMP14, CCND1, BIRC5
14pge2438.3VEGFC, SERPINB2, BIRC5, NME1, CTSD
15wortmannin438.3MMP14, CCND1, BIRC5, EIF4G1, EIF4E
16adriamycin438.3TP53, CCND1, BIRC5, CTSD
17matrigel438.2VEGFC, SERPINB5, SERPINB2, MMP14, CCND1, NME1
18phosphoinositide438.2MMP14, CCND1, BIRC5, EIF4G1, EIF4E
19mg 13243 599.2TP53, CCND1, BIRC5, EIF4G1, EIF4E
20dexamethasone43 49 28 1211.2VEGFC, SERPINB2, CP, MMP14, BIRC5, NME1
21arsenite43 249.2TP53, CCND1, BIRC5, EIF4G1, EIF4E
22tamoxifen43 49 28 1211.1TP53, SERPINB5, CCND1, BIRC5, CTSD
23alanine438.1CP, MMP14, BIRC5, NME1, EIF4G1, EIF4E
24h2o2438.1TP53, SERPINB2, CP, BIRC5, EIF4E, CTSD
25nitric oxide43 24 1210.1VEGFC, SERPINB5, SERPINB2, BIRC5, NME1, EIF4E
26etoposide43 49 59 1211.1TP53, BIRC5, GSTT1, NME1, EIF4G1, EIF4E
27paclitaxel43 49 1210.0AURKA, TP53, CCND1, BIRC5, CTSD
28curcumin437.9TP53, MMP14, CCND1, BIRC5
29pd 98,059437.9VEGFC, MMP14, CCND1, BIRC5, EIF4G1, EIF4E
30threonine437.9AURKA, MMP14, CCND1, BIRC5, EIF4E, ENG
31lipid437.9VEGFC, SERPINB5, SERPINB2, CP, MMP14, BIRC5
32doxorubicin43 49 129.9TP53, CCND1, BIRC5, GSTT1, ENG, CTSD
33oxygen43 248.7VEGFC, CP, MMP14, BIRC5, GSTT1, EIF4E
34testosterone43 59 24 1210.7VEGFC, SERPINB5, CP, CCND1, BIRC5, CTSD
35steroid437.6SERPINB5, SERPINB2, CCND1, BIRC5, GSTT1, NME1
36agar437.4CP, MMP14, CCND1, BIRC5, NME1, EIF4E
37thymidine43 248.4VEGFC, TP53, MMP14, CCND1, BIRC5, NME1
38phosphatidylinositol437.4VEGFC, MMP14, CCND1, BIRC5, EIF4G1, EIF4E
39ly294002437.4VEGFC, TP53, MMP14, CCND1, BIRC5, EIF4G1
40calcium43 49 24 1210.3SERPINB2, MMP14, BIRC5, NME1, EIF4G1, EIF4E
41tyrosine437.3VEGFC, SERPINB2, MMP14, CCND1, BIRC5, NME1
42cycloheximide437.2TP53, SERPINB2, MMP14, CCND1, BIRC5, EIF4G1
43cisplatin43 49 59 1210.0TP53, SERPINB5, CCND1, BIRC5, GSTT1, NME1
44oligonucleotide437.0VEGFC, TP53, MMP14, CCND1, BIRC5, GSTT1
45retinoic acid43 247.6VEGFC, TP53, SERPINB2, CP, CCND1, BIRC5
46paraffin436.6VEGFC, TP53, SERPINB5, SERPINB2, MMP14, CCND1
47serine436.1CP, SERPINB2, SERPINB5, TP53, AURKA, MMP14
48progesterone43 28 59 24 129.9SERPINB2, MMP14, CCND1, BIRC5, NME1, EIF4G1
49vegf435.5VEGFC, TP53, SERPINB5, SERPINB2, CP, MMP14
50estrogen435.3SERPINB2, CP, MMP14, CCND1, BIRC5, GSTT1

GO Terms for genes affiliated with Laryngeal Carcinoma

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Cellular components related to Laryngeal Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1eukaryotic translation initiation factor 4F complexGO:00162819.7EIF4E, EIF4G1
2spindle microtubuleGO:00058769.6BIRC5, AURKA
3extracellular spaceGO:00056158.2VEGFC, SERPINB5, SERPINB2, CP, ENG, CTSD
4cytoplasmGO:00057377.3TP53, SERPINB5, SERPINB2, MMP14, BIRC5, NME1
5cytosolGO:00058297.1EIF4E, AURKA, TP53, CCND1, BIRC5, GSTT1

Biological processes related to Laryngeal Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of mitotic cell cycleGO:00459319.5EIF4E, BIRC5
2nuclear-transcribed mRNA poly(A) tail shorteningGO:00002899.5EIF4E, EIF4G1
3extracellular matrix disassemblyGO:00226179.4CTSD, ENG, MMP14
4mitotic G1 DNA damage checkpointGO:00315719.2CCND1, TP53
5response to X-rayGO:00101659.0TP53, CCND1

Molecular functions related to Laryngeal Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein kinase bindingGO:00199018.6NME1, CCND1, TP53, AURKA
2chaperone bindingGO:00510878.6TP53, CP, BIRC5
3protein bindingGO:00055155.4CTSD, AURKA, VEGFC, TP53, SERPINB5, MMP14

Products for genes affiliated with Laryngeal Carcinoma

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  • Antibodies
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  • Kits and Assays

Sources for Laryngeal Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet