Laryngeal Carcinoma malady

Wikipedia: Laryngeal cancer may also be called cancer of the larynx or laryngeal carcinoma. Most laryngeal cancers...⁴⁴ more...

MalaCards: Laryngeal Carcinoma, also known as larynx cancer, is related to squamous cell carcinoma and prostate carcinoma. An important gene associated with Laryngeal Carcinoma is GGNBP2 (gametogenetin binding protein 2), and among its related pathways are Signal transduction AKT signaling and Signal transduction_PTEN pathway. The drugs carmustine and diethylstilbestrol diphosphate and the compounds threonine and nicotine have been mentioned in the context of this disorder. Affiliated tissues include the larynx, lymph node and breast, and related mouse phenotypes are respiratory system and hematopoietic system.

Disease Ontology: A respiratory system cancer that is located in the larynx.⁶

Aliases & Descriptions:

laryngeal carcinoma 6 32 larynx cancer 6 8 carcinoma of larynx (disorder) 6 malignant neoplasm of larynx 43

carcinoma of larynx 43 malignant neoplasms 43 cancer of larynx 6 carcinoma 43

Diseases related to laryngeal carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1884)

id	Related Disease	Score	Top Affiliating Genes
1	squamous cell carcinoma	42.2	LGALS1, CD44, CDH1, MMP12, MMP7, MKI67
2	prostate carcinoma	37.8	NAT2, VEGFA, CD82, CDH1, MMP9, GSTM1
3	basal cell carcinoma	37.4	BCL2, LGALS1, BAK1, BAX, XRCC1, CD44
4	papillary thyroid carcinoma	36.7	SERPINB5, VEGFC, RASSF1, BAX, S100A1, CD44
5	adenoid cystic carcinoma	35.3	PCNA, SERPINB5, RASSF1, MUC1, S100A1, S100B
6	renal cell carcinoma	35.1	RELA, PCNA, SERPINB2, BSG, VEGFA, VEGFC
7	merkel cell carcinoma	35.1	KDR, MUC1, FHIT, TNC, EPCAM
8	mucoepidermoid carcinoma	34.4	PCNA, MUC1, S100A1, CDKN1B, IVL, MKI67
9	small cell carcinoma	34.3	PCNA, RB1, VEGFA, RASSF1, BCL2, MUC1
10	lung carcinoma	34.0	PCNA, BTG2, RB1, SERPINB5, SERPINB2, BSG
11	adrenocortical carcinoma	33.8	RB1, S100B, FGF2, MAPK3, TP53, CYP1A1
12	adenosquamous carcinoma	33.7	MUC1, IVL, FHIT, CTSD, EGFR, TGFA
13	non-small cell lung carcinoma	33.6	PCNA, RB1, VEGFA, VEGFC, MYC, RASSF1
14	chromophobe renal cell carcinoma	33.0	PCNA, MUC1, S100A1, MET, CCND1, EGF
15	thymic carcinoma	32.7	VEGFC, BCL2, MUC1, S100A1, PTGS2, EGFR
16	papillary renal cell carcinoma	32.7	PCNA, VEGFA, VEGFC, RASSF1, KDR, MUC1
17	anaplastic carcinoma	32.5	LGALS1, MUC1, CDH1, FHIT, SLC2A1, NME1
18	renal oncocytoma	32.5	PCNA, MUC1, S100A1, CD82, CCND1, TP53
19	liver cirrhosis	32.5	SERPINB2, RASSF1, ITGB1, ANGPT2, F2R, HPSE
20	bronchogenic carcinoma	32.4	CDKN1A, CDKN2A, MGST1, GSTM3, IL10, IL2
21	lymphoepithelioma-like carcinoma	32.3	BCL2, MUC1, S100B, CDH1, TP53, EGFR
22	hepatitis c	32.3	MMP1, IL10, IL18, IL2, IL4, ENG
23	multiple endocrine neoplasia	32.3	CDKN1A, CDKN1B, CDKN2A, CDH1, FOXN3, FGF2
24	verrucous carcinoma	32.3	PCNA, RB1, CDKN1A, CDKN2A, CD44, CDH1
25	salivary gland cancer	32.1	SERPINB5, BIRC5, MMP9, MET, CASP3, AKT1
26	basaloid squamous cell carcinoma	32.1	PCNA, MYC, BIRC5, BCL2L1, BAX, S100A1
27	bile duct carcinoma	32.0	VEGFC, MYC, BCL2, MUC1, CDKN2A, CD44
28	pleomorphic adenoma	32.0	PCNA, SERPINB5, MUC1, S100A1, S100B, CDKN1B
29	hypercalcemia	31.9	FGF2, IL2, CCND1, CCL3, IFNG, EGF
30	stomach carcinoma	31.9	RASSF1, CDKN2A, CD44, CDH1, CCND1, PLAU
31	oral cavity cancer	31.8	NAT2, VEGFA, BAX, GSTM1, GSTT1, IL18
32	skin carcinoma	31.8	CDH1, IVL, MMP2, GSTM1, GSTP1, GSTT1
33	colorectal cancer	31.8	NAT2, GSTM1, GSTP1, GSTT1, CCND1, TP53
34	neuroendocrine carcinoma	31.6	PCNA, VEGFA, BCL2, MUC1, S100B, CDKN1A
35	breast cancer	31.5	SERPINB5, MYC, MTA1, AURKA, CDK2, CDKN1B
36	cervix carcinoma	31.5	MYC, CDKN1A, CDKN2A, CD44, MKI67, MET
37	brain cancer	31.4	GSTM1, GSTM3, GSTT1, CYP1A1, NFKB1
38	keratoacanthoma	31.3	PCNA, BCL2, BCL2L1, MUC1, BAK1, CDKN1A
39	pleomorphic carcinoma	31.3	MUC1, CDKN1B, IVL, TP53, EGFR
40	sweat gland carcinoma	31.3	PCNA, MUC1, S100A1, S100B, ERBB2, TP53
41	actinic keratosis	31.2	PCNA, RB1, MYC, BCL2, CDKN1B, CDKN2A
42	ovarian cancer	31.1	RB1, CDKN1A, CDK2, CDKN1B, CDKN2A, CCND1
43	clear cell renal cell carcinoma	31.1	RELA, BTG2, VEGFA, VEGFC, MYC, RASSF1
44	keratosis	31.1	PCNA, RB1, MYC, BCL2, S100B, CDKN1A
45	lung giant cell carcinoma	31.0	PCNA, CDKN2A, CDH1, MMP2, IL8, TIMP1
46	pleomorphic adenoma carcinoma	30.9	XIAP, CDKN2A, CCND1, ERBB2, TP53, CTNNB1
47	renal clear cell carcinoma	30.9	VEGFA, RASSF1, BIRC5, KDR, BCL2, MUC1
48	cervical squamous cell carcinoma	30.9	BSG, MYC, RASSF1, BIRC5, BCL2, MUC1
49	gallbladder carcinoma	30.8	PCNA, RB1, BSG, VEGFA, VEGFC, MYC
50	colorectal adenoma and carcinoma	30.8	PCNA, VEGFA, BCL2, MUC1, BAK1, BAX

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 carmustine, diethylstilbestrol, diethylstilbestrol diphosphate, nilutamide

MalaCards organs/tissues related to laryngeal carcinoma:

²²

FMA organs/tissues related to laryngeal carcinoma:

¹¹

MGI Mouse Phenotypes related to laryngeal carcinoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.7	F13A1, CTSA, CTSH
2	hematopoietic system phenotype	MP:0005397	10.7	PCNA, SERPIND1, SERPINB2, BNIP3, BCL2, BCL2L1
3	craniofacial phenotype	MP:0005382	10.2	ILK, MAP2K1, HSPG2, TRAF6, TERF1, CTSA
4	embryogenesis phenotype	MP:0005380	9.9	SERPINB5, MYC, BIRC5, XRCC1, AURKA, FLT4
5	pigmentation phenotype	MP:0001186	9.4	RB1, MYC, BCL2, CDKN1B, CDKN2A, ITGB1
6	endocrine/exocrine gland phenotype	MP:0005379	9.1	PDCD4, CDKN1B, IL2, AQP1, IFNG, CA9
7	immune system phenotype	MP:0005387	8.8	PDCD4, SERPINB2, BSG, KDR, LGALS1, BAK1
8	renal/urinary system phenotype	MP:0005367	8.8	PDCD4, SERPIND1, BCL2, BAK1, BAX, CDKN1A
9	other phenotype	MP:0005395	8.7	KDR, CDKN2A, ITGB1, MMP14, FN1, IL2
10	no phenotypic analysis	MP:0003012	8.5	PCNA, RB1, VEGFA, MYC, MUC1, CDKN1B
11	limbs/digits/tail phenotype	MP:0005371	8.2	RELA, RB1, VEGFA, VCAN, BAK1, BAX
12	liver/biliary system phenotype	MP:0005370	8.1	VEGFA, BAG1, MET, IL2, IFNG, HYAL1
13	nervous system phenotype	MP:0003631	8.0	RELA, BTG2, RB1, VCAN, MYC, BCL2L1
14	hearing/vestibular/ear phenotype	MP:0005377	8.0	RB1, MYC, BCL2, BAK1, BAX, CDKN1A
15	integument phenotype	MP:0010771	7.9	RELA, RB1, MYC, BCL2, BCL2L1, LGALS1
16	mortality/aging	MP:0010768	7.8	PDCD4, RELA, RB1, SERPINB5, SERPIND1, SERPINB2
17	adipose tissue phenotype	MP:0005375	7.5	RB1, MYC, BCL2, CDKN1A, CDKN1B, FLT4
18	normal phenotype	MP:0002873	7.4	RELA, VEGFA, VCAN, MYC, KDR, LGALS1
19	skeleton phenotype	MP:0005390	7.1	RELA, BTG2, RB1, VEGFA, VCAN, MYC
20	growth/size phenotype	MP:0005378	6.8	RELA, RB1, SERPINB2, BSG, MYC, PARK7
21	behavior/neurological phenotype	MP:0005386	6.4	RB1, PARK7, KDR, LGALS1, XRCC1, S100A1
22	reproductive system phenotype	MP:0005389	6.0	PDCD4, VEGFA, CDKN1B, CD44, CDH1, ITGB1
23	digestive/alimentary phenotype	MP:0005381	5.6	RB1, VEGFA, MYC, BCL2, MUC1, CDKN1A
24	vision/eye phenotype	MP:0005391	4.5	RELA, RB1, VEGFA, KDR, BCL2, MUC1
25	tumorigenesis	MP:0002006	4.1	PDCD4, RB1, MYC, RASSF1, BCL2, BCL2L1
26	homeostasis/metabolism phenotype	MP:0005376	4.1	RELA, RB1, SERPIND1, SERPINB2, NAT2, VEGFA
27	muscle phenotype	MP:0005369	3.5	RELA, RB1, SERPIND1, SERPINB2, VEGFA, BNIP3
28	cardiovascular system phenotype	MP:0005385	2.5	RELA, RB1, SERPIND1, VEGFA, VEGFC, BNIP3
29	cellular phenotype	MP:0005384	2.3	RELA, PCNA, RB1, SERPINB5, SERPIND1, VEGFA

Articles related to laryngeal carcinoma:

(show top 50)    (show all 207)

id	Title	Authors	Year	Affiliating Genes
1	Effect of human papillomavirus on cell cycle-related proteins p16INK4A, p21waf1/cip1, p53 and cyclin D1 in sinonasal inverted papill oma and laryngeal carcinoma. An in situ hybridization study. (21526487)	Stasikowska-Kanicka O.... Danilewicz M.	2011	TP53, CCND1, CDKN1A
2	The association between genetic polymorphisms of GST M1, GSTT1, GSTP1 and susceptibility to laryngeal carcinoma from the Han people in Guangdong zone]. (21604464)	Tian S.... Guan Z.	2011	GSTP1, GSTT1, GSTM1
3	Effects of protein kinase CK2I+ on apoptosis and ultr astructure of laryngeal carcinoma cells]. (21162802)	Wang J.T.... Gong S.S.	2010	CSNK2A1
4	Fibronectin induces matrix metalloproteinase-9 (MMP-9 ) in human laryngeal carcinoma cells by involving multiple signaling pathways. (20638438)	Sen T.... Chatterjee A.	2010	MMP9, FN1
5	Neoangiogenesis in laryngeal carcinoma: angiogenin an d CD105 expression is related to carcinoma recurrence rate and disease-free sur vival. (20955379)	Marioni G.... Staffieri A.	2010	ENG, ANG
6	The expression of EMS1 and DcR3 protein in laryngeal carcinoma and the relation between EMS1 and DcR3]. (21395182)	Li L.... Yue W.	2010	CTTN, TNFRSF6B
7	Significance of the counteracting oxidative and antioxidative systems in the pathogenesis of laryngeal carcinoma. (19442365)	Kacakci A.... Aydemir B.	2009	SOD1
8	Expression of Epidermal Growth Factor Receptor varian t III in laryngeal carcinoma tissues. (19427146)	Yang B.... Cao J.	2009	EGFR
9	Effect of RNA interference mediated gene silencing o f DJ-1 on proliferation of laryngeal carcinoma cell line Hep-2 (18717316)	Zhu X.L.... Su Z.Z.	2008	PARK7
10	Expression and implication of CD44 and nm23-H1 proteins in laryngeal carcinoma (18476632)	Yang X.... Yang Z.	2008	CD44, NME1
11	Suppression of survivin expression by short hairpin RNA induces apoptosis in human laryngeal carcinoma cells. (18391576)	Chen X.M.... Pan X.L.	2008	BIRC5
12	Expression of PD4, CD44v6, CD44v9 and its clinical s ignificance in human laryngeal carcinoma]. (18476625)	Sun B.... Yan Q.	2008	CD44, PDCD4
13	Overexpression of intrinsic hypoxia markers HIF1alpha and CA-IX predict for local recurrence in stage T1-T2 glottic laryngeal carcinoma treated with radiotherapy. (18722267)	Schrijvers M.L.... van der Wal J.E.	2008	SLC2A1, HIF1A, CA9
14	Expressions of NF-kappaB p65 in laryngeal carcinoma and normal mucous membrane and its clinical significance]. (17969521)	Zhang L.... Yu L.	2007	RELA
15	Expression of STAT3 and P-STAT3 in laryngeal carcinoma and its clinical significance (17441424)	Wang J.... Lu X.	2007	STAT3
16	Soluble EMMPRIN (extra-cellular matrix metalloproteinase inducer) stimulates the migration of HEp-2 human laryngeal carcinoma cells, accompanied by increased MMP-2 production in fibroblasts. (18431027)	Hanata K.... Ishikawa K.	2007	MMP2, BSG
17	Expression of inhibitor of apoptosis protein XIAP in laryngeal carcinoma and its clinocopathological significance (18309651)	Li X.... Dong W.	2007	XIAP
18	Assessment of expression of toll-like receptors 2, 3 and 4 in laryngeal carcinoma. (17165086)	SzczepaA8ski M.... Zeromski J.	2007	TLR3, TLR2, TLR4
19	Study of the SH3-domain GRB2-like 2 gene expression in laryngeal carcinoma. (17376308)	Shang C.... Sun K.L.	2007	SH3GL2
20	Expression of metalloproteinases and their tissue inhibitors in squamous cell laryngeal carcinoma. (17786346)	Christopoulos T.A.... Vynios D.H.	2007	MMP2, MMP9, TIMP2
21	Relationship among lymphangiogensis, vascular endothelial growth factor-C mRNA expression and cervical lymphatic metastasis in laryngeal carcinoma (17039808)	Tai X.H.... Sun X.H.	2006	VEGFC
22	Maspin nuclear localization is related to reduced density of tumour-associated micro-vessels in laryngeal carcinoma. (17214364)	Marioni G.... Blandamura S.	2006	SERPINB5
23	Human papillomavirus and Epstein-Barr virus infection, p53 expression, and cellular proliferation in laryngeal carcinoma. (16891205)	de Oliveira D.E.... Bacchi C.E.	2006	TP53
24	Expression of the apoptosis inhibitor protein Survivin in primary laryngeal carcinoma and cervical lymph node metastasis. (17094406)	Marioni G.... Staffieri A.	2006	BIRC5
25	STK15 gene overexpression, centrosomal amplification, and chromosomal instability in the absence of STK15 mutations in laryngeal carcinoma. (16377583)	Li Y.... Sun K.	2005	AURKA
26	Cyclin D1, p53, MIB1, intratumoral microvessel density, and human papillomavirus in advanced laryngeal carcinoma: association with nodal metastasis. (15467627)	Kumar R.V.... Shah K.V.	2004	TP53, CCND1
27	Application of tissue microarray: evaluation of the expression of S-100-positive dendritic cells, tumor suppressor gene p63 and tissue inhibitor of metalloproteinase-1 in laryngeal carcinoma. (15768819)	Dong P.... Wang S.	2004	TIMP1
28	A study on the expression of TGF-beta 1/T beta R II in laryngeal carcinoma (14503367)	Yang S.... Li Y.	2003	TGFB1
29	p53, Ki67 and cyclin D1 as prognosticators of lymph node metastases in laryngeal carcinoma. (14551784)	Mielcarek-Kuchta D.... Golusinski W.	2003	TP53, CCND1, MKI67
30	Alterations in the content and composition of glycosa minoglycans in human laryngeal carcinoma. (12030585)	Papadas T.A.... Vynios D.H.	2002	GALNS
31	Expression of p27 protein and cyclinD1 in laryngeal carcinoma (12669430)	Zhang L.... Yu L.	2002	CCND1, IFI27
32	The expression of IL-8 on laryngeal carcinoma and edge tissues (12669441)	Song J.... Dai S.	2002	IL8
33	Genetic polymorphism of cytochrome P4501A1 and susceptibility to laryngeal carcinoma (12772461)	Lei D.... Liu D.	2002	CYP1A1
34	Expression of VEGF and VEGF-C in laryngeal carcinoma and their clinical significance (12669432)	Yang Y.... Ge R.	2002	VEGFC
35	Prognostic significance of p53, bax and bcl-2 gene expression in patients with laryngeal carcinoma. (11520092)	Georgiou A.... Androulakis G.	2001	TP53, BCL2, BAX
36	Assessment of usefulness of PCNA and oncoprotein p53 staining in prediction of the recurrences in subjects operated on for laryngeal carcinoma (11070693)	Morawski K.... Urbaniec P.	2000	PCNA
37	Mutants of p53 gene presence in laryngeal carcinoma a nd adjacent histopathologically normal tissue. (10810258)	Jin X.... Zhao A.	2000	TP53
38	The status of protein P16 and P53 in the surgical margins of laryngeal carcinoma and the association with local recurrence (12768762)	Wei B.... Tu G.	2000	TP53
39	nm23-H1 protein expression and its clinical significance in human laryngeal carcinoma (11387948)	Liang C.... Xu G.	1999	NME1
40	Expression of membrane type 1-matrix metalloproteinase in laryngeal carcinoma. (10491020)	Du B.... Du B.	1999	MMP14
41	Expression of MMP-1, TIMP-1, and type I collagen in laryngeal carcinoma. (9758368)	Sawatsubashi M.... Shin T.	1998	MMP1, TIMP1
42	Is p53 an independent prognostic factor in patients with laryngeal carcinoma? (9445184)	Narayana A.... Reddy S.P.	1998	TP53
43	Thrombin receptor activation results in calcium signaling and protein kinase C-dependent stimulation of DNA synthesis in HEp-2g laryngeal carcinoma cells. (9392328)	Kaufmann R.... Nowak G.	1997	F2R, DYT10
44	Study on HPV infection and p53 protein expression in laryngeal carcinoma (10323025)	Qin Z.... Dong M.	1997	TP53
45	TGF-alpha immunoreactivity in laryngeal carcinoma: lack of prognostic value and correlation to EGF-receptor expression. (8678876)	Lee C.S.... Boag G.	1996	TGFA
46	Serum dihydrotestosterone versus total testosterone values of patients with laryngeal carcinomas and chronic laryngitis (8766382)	Kleemann D.... Kunkel S.	1996	SRD5A1
47	Cervical lymph node status and survival in laryngeal carcinoma: prognostic factors. (7661516)	Resnick J.M.... Jaszcz W.	1995	EGFR, TP53, CTSD
48	Transforming growth factor alpha and epidermal growth factor in laryngeal carcinomas demonstrated by immunohistochemistry. (7691024)	Christensen M.E.... Bretlau P.	1993	TGFA
49	Over-expression of p53 protein in human laryngeal carcinoma. (8386140)	Anwar K.... Inuzuka M.	1993	TP53
50	Determination of oxidative activity of ceruloplasmin using Ravin's method in patients with laryngeal carcinoma (1437172)	Kornatowski T.... Durko T.	1992	CP

Genes related to laryngeal carcinoma according to GeneCards:

(show top 50)    (show all 171)

id	Symbol	Description	Score	GeneCards Section Context
1	GGNBP2	gametogenetin binding protein 2	11.1	UniProt Related, Aliases & Descriptions
2	NME1	NME/NM23 nucleoside diphosphate kinase 1	11.0	Publications
3	CTTN	cortactin	11.0	Publications
4	SERPINB5	serpin peptidase inhibitor, clade B (ovalbumin), member 5	11.0	Publications
5	ENG	endoglin	11.0	Publications
6	BAK1	BCL2-antagonist/killer 1	11.0	Publications
7	AURKA	aurora kinase A	11.0	Publications
8	IFI27	interferon, alpha-inducible protein 27	11.0	Publications
9	EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	11.0	Publications
10	CTSD	cathepsin D	11.0	Publications
11	MTA1	metastasis associated 1	11.0
12	EIF4E	eukaryotic translation initiation factor 4E	11.0	Publications
13	PCNA	proliferating cell nuclear antigen	11.0	Publications
14	CCND1	cyclin D1	11.0	Publications
15	MMP14	matrix metallopeptidase 14 (membrane-inserted)	11.0	Publications
16	HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	11.0	Publications
17	CP	ceruloplasmin (ferroxidase)	11.0	Publications
18	VEGFC	vascular endothelial growth factor C	11.0	Publications
19	SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	11.0
20	HSPB1	heat shock 27kDa protein 1	11.0	Publications
21	BCL2	B-cell CLL/lymphoma 2	11.0	Publications
22	GSTT1	glutathione S-transferase theta 1	11.0	Publications
23	RB1	retinoblastoma 1	11.0	Publications
24	TERT	telomerase reverse transcriptase	11.0	Publications
25	FLT4	fms-related tyrosine kinase 4	11.0
26	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
27	TP53	tumor protein p53	11.0	Publications
28	BIRC5	baculoviral IAP repeat containing 5	11.0	Publications
29	NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	11.0	Publications
30	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0	Publications
31	HLA-A	major histocompatibility complex, class I, A	11.0	Publications
32	EGFR	epidermal growth factor receptor	11.0	Publications
33	PLAU	plasminogen activator, urokinase	11.0	Publications
34	HSPA8	heat shock 70kDa protein 8	11.0
35	CD4	CD4 molecule	11.0
36	FHIT	fragile histidine triad	11.0	Publications
37	BRMS1	breast cancer metastasis suppressor 1	10.9	Publications
38	ECM1	extracellular matrix protein 1	10.9	Publications
39	TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy	10.9	Publications
40	EMP1	epithelial membrane protein 1	10.9	Publications
41	BTG2	BTG family, member 2	10.9	Publications
42	PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)	10.9	Publications
43	GSTM3	glutathione S-transferase mu 3 (brain)	10.9	Publications
44	DHRS11	dehydrogenase/reductase (SDR family) member 11	10.9
45	SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	10.9
46	MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	10.9	Publications
47	MGST1	microsomal glutathione S-transferase 1	10.9	Publications
48	ZYX	zyxin	10.9	Publications
49	MIR21	microRNA 21	10.9	Publications
50	SPAM1	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	10.9	Publications

Pathways related to laryngeal carcinoma according to GeneDecks:

(show top 50)    (show all 255)

id	Pathway	Score	Top Affiliating Genes
1	Signal transduction AKT signaling10	11.0	HSP90AB1
2	Signal transduction_PTEN pathway41	10.9	PCNA, ITGB1
3	Transcription P53 signaling pathway10	10.5	RELA, VEGFA, CDK2, CDKN2A, TP53
4	Cell adhesion ECM remodeling10	10.0	VCAN, CD44, ITGB1, MMP1, MMP12, MMP14
5	Cell adhesion_ECM remodeling41	10.0	VCAN, CD44, ITGB1, MMP1, MMP12, MMP14
6	Non-small cell lung cancer20	9.9	RB1, RASSF1, CDKN2A, FHIT, MAP2K1, AKT1
7	Transcription_P53 signaling pathway41	9.8	RELA, RB1, VEGFA, KDR, BCL2, CDKN1A
8	Signal transduction PTEN pathway10	9.8	PCNA, CDKN1A, ITGB1, MAPK3, MAP2K1, CASP3
9	Glioblastoma Multiforme36	9.7	RB1, CDKN1A, CDK2, CDKN1B, MAPK3, MAP2K1
10	Development_EGFR signaling pathway41	9.6	MYC, MMP2, MMP9, ILK, MAPK3, MAP2K1
11	Signal transduction_AKT signaling41	9.6	RELA, PCNA, MYC, BCL2L1, BAX, CDKN1A
12	Angiogenesis3	9.4	SERPINB5, VEGFC, KDR, ITGB1, MMP2, MMP7
13	Focal adhesion20	9.4	VEGFC, KDR, BCL2, XIAP, ITGB1, FN1
14	Small cell lung cancer20	9.4	RELA, RB1, MYC, BCL2, BCL2L1, XIAP
15	Melanoma20	9.4	RB1, CDKN1A, CDKN2A, CDH1, FGF2, MET
16	Prostate cancer20	9.3	RELA, RB1, BCL2, CDKN1A, CDK2, CDKN1B
17	Endometrial cancer20	9.3	MYC, CDH1, ILK, MAPK3, MAP2K1, CCND1
18	Regulation of eIF4 and p70S6K36	9.2	VEGFC, BAX, CD4, ITGB1, IL18, IL2
19	Telomerase Components in Cell Signaling36	9.1	RB1, VEGFC, MYC, KDR, FLT1, FLT4
20	PTEN Pathway36	9.1	VEGFC, KDR, FN1, FLT1, FLT4, FGF2
21	Bladder cancer20	8.9	RB1, VEGFA, VEGFC, MYC, RASSF1, CDKN1A
22	Akt Signaling36	8.9	VEGFC, CD4, FLT4, MET, IL10, IL18
23	ILK Signaling36	8.8	VEGFC, KDR, CDH1, ITGB1, FN1, FLT4
24	IL-6 Pathway36	8.7	BAX, IL10, IL18, IL4, IL8, ANGPT2
25	Chronic myeloid leukemia20	8.6	RELA, RB1, MYC, BCL2L1, CDKN1A, CDKN1B
26	Mitochondrial Apoptosis36	8.2	VEGFC, KDR, BCL2, BCL2L1, BAK1, BAX
27	p53 Mediated Apoptosis36	8.2	VEGFC, KDR, BCL2, BAX, FLT1, FLT4
28	NF-KappaB Family Pathway36	8.2	RELA, VEGFC, KDR, FLT1, FLT4, FGF2
29	NF-KappaB (p50-p65) Pathway36	8.2	RELA, VEGFC, KDR, FLT1, FLT4, FGF2
30	Rac1 Pathway36	8.2	KDR, ITGB1, FLT4, FGF2, MET, IL2
31	STAT3 Pathway36	8.1	MYC, BCL2, BAX, CDKN1A, CD4, MET
32	Endothelin-1 Signaling Pathway36	8.1	MYC, FLT1, FLT4, IL10, IL18, IL2
33	Cellular Apoptosis Pathway36	7.9	VEGFC, KDR, BCL2, BCL2L1, BAK1, BAX
34	DHA Signaling36	7.9	VEGFC, KDR, BCL2, BCL2L1, BAX, FLT1
35	MAPK Signaling36	7.7	VEGFC, MYC, KDR, BCL2, ITGB1, FN1
36	PAK Pathway36	7.4	VEGFC, KDR, BCL2, BAX, FLT1, FLT4
37	Toxoplasmosis20	7.4	RELA, BCL2, BCL2L1, XIAP, ITGB1, IL10
38	MAPK Family Pathway36	7.3	VEGFC, KDR, BCL2, BAX, CD4, FLT1
39	Antioxidant Action of Vitamin-C36	7.1	VEGFC, KDR, BCL2, BAX, CD4, FLT1
40	Pancreatic Adenocarcinoma36	7.1	RB1, VEGFC, BIRC5, KDR, BCL2, BCL2L1
41	Molecular Mechanisms of Cancer36	7.1	RB1, VEGFC, MYC, KDR, BCL2, BCL2L1
42	TGF-Beta Pathway36	7.1	VEGFC, KDR, BCL2, BAX, CD4, CDH1
43	Colorectal Cancer Metastasis36	6.9	MYC, BIRC5, BCL2L1, BAX, CDKN1A, CDH1
44	p38 Signaling36	6.8	VEGFC, KDR, BCL2, BAX, CD4, FLT1
45	Tec Kinases Signaling36	6.8	VEGFC, BCL2, BAX, CD4, ITGB1, FGF2
46	Pathways in cancer20	6.8	RELA, RB1, VEGFA, VEGFC, MYC, RASSF1
47	Rho Family GTPases36	6.7	VEGFC, KDR, BCL2, BAX, CDH1, ITGB1
48	ERK Signaling36	6.6	VEGFC, MYC, ITGB1, FN1, FLT1, FLT4
49	Cytokine-cytokine receptor interaction20	6.3	VEGFA, VEGFC, KDR, FLT1, FLT4, MET
50	JAK-STAT Pathway36	5.4	VEGFC, MYC, KDR, BCL2, BAX, CD4

Compounds related to laryngeal carcinoma according to GeneDecks:

(show top 50)    (show all 446)

id	Compound	Score	Top Affiliating Genes
1	threonine32	10.8	CDKN1B, CD4, ILK, F2R, CTTN, NRP1
2	nicotine32 34 9 9	13.8	RB1, BIRC5, IVL, CCR7
3	roscovitine32	10.4	PCNA, BIRC5, BCL2L1, XIAP, MAPK3, MAP2K1
4	adpribose32	10.4	PCNA, RB1, BIRC5, BCL2L1, BAK1, BAX
5	dmso32	10.2	MMP7, MAP2K1, F2R, HSPG2, CTSD, CTSB
6	ascorbic acid32 18	11.1	PCNA, SERPINB2, XRCC1, S100B, MMP2, GSTM1
7	okadaic acid32 42	11.0	RELA, RB1, SERPINB2, MYC, BCL2, BCL2L1
8	4-hydroxytamoxifen32	10.0	MYC, S100B, MAP2K1, HSPB1, ERBB2, CYP1A1
9	p00332	10.0	RB1, RASSF1, S100B, CDKN1B, CD44, CDH1
10	egcg32	9.9	BCL2L1, XIAP, CDK2, IVL, MAPK3, MAP2K1
11	p00232	9.8	RB1, SERPINB5, BIRC5, XRCC1, CD44, CDH1
12	trastuzumab32 34 9 9	12.8	VEGFC, BIRC5, KDR, MUC1, CDK2, CDKN1B
13	heparan sulfate32 18	10.8	BSG, VCAN, KDR, LGALS1, CD4, CD44
14	camptothecin32 42 9 9	12.5	PCNA, RB1, MYC, BIRC5, KDR, BCL2
15	steroid32	9.5	RB1, SERPINB5, SERPINB2, BIRC5, BAG1, S100B
16	aspartate32	9.5	PCNA, S100B, AURKA, CDKN2A, CDH1, MMP2
17	lipid32	9.4	RB1, SERPINB5, SERPINB2, BSG, VEGFC, BIRC5
18	irinotecan32 34 9 9	12.4	VEGFA, BCL2L1, BAK1, BAX, XRCC1, CDKN1A
19	cytarabine32 34 9 9	12.4	PCNA, RB1, MYC, BCL2, BCL2L1, MUC1
20	hyaluronic acid32 18	10.3	VCAN, MYC, MUC1, CD44, CDH1, MMP1
21	ns 39832 42	10.3	PCNA, CDKN1B, MMP1, FGF2, IL8, NOS2
22	bromodeoxyuridine32	9.2	PCNA, RB1, MYC, S100B, CDKN1A, CDK2
23	retinoid32	9.2	MYC, LGALS1, BAK1, BAX, S100A8, CDKN1A
24	betacarotene32	9.2	PCNA, RB1, NAT2, XRCC1, IVL, MMP1
25	phosphotyrosine32	9.2	KDR, LGALS1, CDK2, CD4, CDH1, ITGB1
26	phorbol32	9.1	SERPINB2, MYC, CDKN1A, CDK2, CD4, MMP1
27	thymidylate32	9.1	PCNA, RB1, VEGFA, BIRC5, BCL2, BCL2L1
28	estrogen32	9.0	PCNA, BTG2, SERPINB5, SERPINB2, BSG, NAT2
29	aspirin32 34 18	10.9	PCNA, SERPINB5, BIRC5, CDH1, MMP1, MMP2
30	gf 109203x32 42	9.8	VEGFA, CDKN1A, IVL, MMP1, FN1, FGF2
31	mifepristone32 42 9 9	11.8	BIRC5, BCL2L1, MUC1, BAX, CDK2, MMP1
32	bortezomib32 9 9	10.6	VEGFA, MYC, BIRC5, KDR, BCL2, BCL2L1
33	suberoylanilide hydroxamic acid32	8.6	MYC, BIRC5, BCL2, BCL2L1, BAX, XIAP
34	creatinine32	8.1	PCNA, MUC1, XRCC1, S100A8, S100B, CDK2
35	troglitazone32 42 9 9	11.0	RB1, BIRC5, BCL2, BAK1, BAX, CDKN1A
36	cytochalasin d32 42	8.9	CD44, CDH1, MMP1, MMP14, MMP2, MMP9
37	arsenite32 18	8.8	PCNA, VEGFA, MYC, BIRC5, BCL2, BCL2L1
38	wortmannin32 42	8.7	BIRC5, KDR, BCL2, BCL2L1, BAX, S100B
39	gemcitabine32 34 9 9	10.7	PCNA, VEGFA, BNIP3, MYC, BIRC5, KDR
40	quercetin32 42 9 18 9	11.6	BIRC5, BCL2, BCL2L1, BAK1, BAX, CDK2
41	imatinib32 34 9 9	10.2	VEGFA, MYC, BIRC5, KDR, BCL2, BCL2L1
42	tamoxifen32 34 9 9	10.0	PCNA, SERPINB5, VEGFA, MYC, BIRC5, KDR
43	triptolide32	7.0	VEGFA, BCL2, BAX, IL2, IL8, CCL3
44	rantes32	6.9	CD4, CD44, MMP1, MMP9, IL18, IL2
45	butyrate32	6.7	PCNA, RB1, MYC, BIRC5, BCL2, BCL2L1
46	nitric oxide32 9 18 9	9.6	RB1, SERPINB5, SERPINB2, NAT2, VEGFC, BNIP3
47	pdtc32	6.5	SERPINB5, BIRC5, BCL2, BCL2L1, XIAP, CDKN1A
48	paraffin32	6.5	RELA, PCNA, RB1, SERPINB5, SERPINB2, VEGFA
49	thymidine32 18	6.8	PCNA, RB1, VEGFC, MYC, BIRC5, KDR
50	genistein32 9 18 9	6.3	PCNA, RB1, VEGFA, MYC, BIRC5, KDR

Cellular components related to laryngeal carcinoma according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	melanosome	GO:042470	10.4	CTSB, CTSD, HSPA8, HSP90AB1, MMP14, ITGB1
2	lysosomal lumen	GO:043202	10.4	GALNS, DCN, CTSD, CTSA, HPSE, HSPG2
3	extracellular matrix	GO:031012	9.7	ECM1, SOD1, DCN, CTSD, TNC, HSPG2
4	cell surface	GO:009986	9.6	TLR2, TLR3, TIMP2, TGFA, TGFB1, CXCR4
5	proteinaceous extracellular matrix	GO:005578	9.5	ECM1, TGFB1, TNC, FN1, MMP9, MMP7
6	platelet alpha granule lumen	GO:031093	9.4	TGFB1, TIMP1, EGF, F13A1, FN1, VEGFC
7	perinuclear region of cytoplasm	GO:048471	9.4	NOS2, EGFR, TLR4, TGFA, TF, NME1
8	mitochondrion	GO:005739	9.3	CASP3, ESR2, TP53, CTSA, CTSB, NFKB1
9	external side of plasma membrane	GO:009897	8.7	ICAM1, CTSB, TLR2, TLR4, CXCR4, IFNG
10	nucleoplasm	GO:005654	8.2	AKT1, ESR1, ESR2, TP53, TERF1, TERT
11	cytosol	GO:005829	8.2	TRAF6, TP53, PTEN, PTK2, CTSH, AKT1
12	plasma membrane	GO:005886	6.8	SPAM1, CTNNB1, NRP1, PLAU, ZYX, PTEN
13	cytoplasm	GO:005737	6.4	MAP2K1, MMP14, IVL, CDH1, CDKN2A, CDKN1B
14	extracellular region	GO:005576	6.4	SERPIND1, SERPINB2, ADAM12, PLAU, NRP1, CTSD
15	nucleus	GO:005634	6.1	ERBB2, TRAF6, TP53, TERF1, PTEN, PTGS2
16	extracellular space	GO:005615	5.7	CTSB, CTSH, CTSD, TNFSF9, TNFRSF6B, TNC

Biological processes related to laryngeal carcinoma according to GeneDecks:

(show top 50)    (show all 86)

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix disassembly	GO:022617	10.6	MMP2, MMP9, TIMP2, TIMP1, MMP7, ENG
2	neuron apoptotic process	GO:051402	10.4	GAPDH, CASP3, BCL2, BNIP3, BAX, RB1
3	peptide cross-linking	GO:018149	10.4	IVL, FN1, F13A1, TGM3, CSTA, DSP
4	organ regeneration	GO:031100	10.3	CDKN1A, ADM, BAK1, MKI67, SOCS1, TGFB1
5	cellular response to mechanical stimulus	GO:071260	10.3	ITGB1, IL18, AQP1, TLR4, TLR3, MAPK3
6	G1/S transition of mitotic cell cycle	GO:000082	10.3	PCNA, CDKN1B, BCL2, CDKN1A, RB1, CDKN2A
7	positive regulation of endothelial cell proliferation	GO:001938	10.2	VEGFA, KDR, HIF1A, NRP1, ANG, FGF2
8	release of cytochrome c from mitochondria	GO:001836	10.2	BCL2, BCL2L1, CASP3, MYC, BAX, BAK1
9	response to lipopolysaccharide	GO:032496	10.1	ADM, TLR4, PTGS2, SOCS1, DCN, EDN1
10	Ras protein signal transduction	GO:007265	10.1	TP53, CDKN1A, CDK2, CDKN2A, MAPK3, MAP2K1
11	cell aging	GO:007569	10.1	MET, ICAM1, PDCD4, BCL2, ILK, SOD1
12	cell proliferation	GO:008283	10.1	TP53, EMP1, S100B, PCNA, BCL2L1, BAK1
13	positive regulation of angiogenesis	GO:045766	10.1	ECM1, KDR, FGF2, HIF1A, ANGPT2, FLT1
14	negative regulation of survival gene product expression	GO:008634	10.1	MYC, BCL2L1, BAX, SKP2, BNIP3
15	positive regulation of epithelial cell proliferation	GO:050679	10.0	TGFA, GRN, VEGFC, ERBB2, EGFR, TGFB1
16	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.0	CD44, KDR, CCL3, FLT4, MAPK3, CCR7
17	cellular response to hypoxia	GO:071456	10.0	VEGFA, TWIST1, BNIP3, PTGS2, TP53, HIF1A
18	cellular response to organic cyclic compound	GO:071407	10.0	IL18, TGFB1, CTNNB1, HSP90AB1, CCL3, CDKN1B
19	induction of apoptosis by intracellular signals	GO:008629	9.9	BNIP3, MYC, BCL2, BCL2L1, BAX, XIAP
20	negative regulation of neuron apoptotic process	GO:043524	9.9	TGFA, PARK7, SOD1, HIF1A, F2R, ILK
21	response to DNA damage stimulus	GO:006974	9.9	CCND1, BTG2, MYC, CASP3, RASSF1, BCL2
22	ovarian follicle development	GO:001541	9.8	BCL2L1, SOD1, ESR2, BAX, ICAM1, KDR
23	angiogenesis	GO:001525	9.7	ECM1, MMP2, IL18, TGFA, HSPB1, HIF1A
24	virus-host interaction	GO:019048	9.7	STAT3, CXCR4, MMP1, TGFB1, EIF4E, ITGB1
25	positive regulation of cell migration	GO:030335	9.7	KDR, VEGFA, CTSH, PTK2, EGFR, EDN1
26	response to organic cyclic compound	GO:014070	9.6	MET, CDKN1A, BAK1, BTG2, CTSB, IL4
27	response to wounding	GO:009611	9.6	MET, CASP3, TNC, FN1, CTSB, F2R
28	positive regulation of tumor necrosis factor production	GO:032760	9.6	IL18, TLR4, IFNG, TWIST1, TLR2, TLR3
29	positive regulation of protein phosphorylation	GO:001934	9.6	VEGFA, PTK2, ENG, MAPK3, CCND1, FLT4
30	response to ethanol	GO:045471	9.5	BCL2, BAK1, S100A8, MMP9, SOD1, STAT3
31	positive regulation of MAP kinase activity	GO:043406	9.5	EGFR, VEGFA, TGFB1, FLT1, ILK, ERBB2
32	cellular response to interleukin-1	GO:071347	9.5	MMP9, IL8, NFKB1, HIF1A, EDN1, HYAL1
33	platelet degranulation	GO:002576	9.4	SOD1, TF, TGFB1, TIMP1, FN1, F13A1
34	negative regulation of cell growth	GO:030308	9.2	TGFB1, TP53, ESR2, HYAL1, FGF2, CDKN2A
35	response to hypoxia	GO:001666	9.2	FLT1, NOS2, VEGFA, IL18, ENG, ANG
36	epidermal growth factor receptor signaling pathway	GO:007173	9.2	SH3GL2, MAPK3, TGFA, EGFR, EGF, MAP2K1
37	negative regulation of cell proliferation	GO:008285	9.1	F2R, PTEN, PTGS2, CTNNB1, TIMP2, TGFB1
38	platelet activation	GO:030168	9.0	TGFB1, TIMP1, VEGFA, VEGFC, TF, F13A1
39	negative regulation of apoptotic process	GO:043066	8.9	TIMP1, EGFR, CTSH, PTK2, AKT1, CASP3
40	anti-apoptosis	GO:006916	8.8	SERPINB2, BNIP3, BIRC5, BCL2, BCL2L1, MUC1
41	signal transduction	GO:007165	8.8	CCL7, IL8, GRN, MET, ZYX, PLAU
42	cell cycle arrest	GO:007050	8.7	RB1, CDKN1A, CDKN1B, CDKN2A, MYC, IL8
43	blood coagulation	GO:007596	8.6	F2R, F13A1, AKT1, PTK2, PLAU, NOS2
44	inflammatory response	GO:006954	8.6	CCL7, ECM1, AKT1, PTGS2, NFKB1, TLR2
45	positive regulation of nitric oxide biosynthetic process	GO:045429	8.5	TLR4, TLR2, EGFR, PTGS2, IFNG, ICAM1
46	apoptotic process	GO:006915	8.2	PTEN, TNFRSF6B, TNFSF9, LGALS1, PTK2, CTNNB1
47	positive regulation of cell proliferation	GO:008284	8.0	ADM, EPCAM, BIRC5, EDN1, CTSH, FGF2
48	positive regulation of transcription, DNA-dependent	GO:045893	7.6	IL4, IL10, ILK, FGF2, CDH1, CDKN2A
49	response to drug	GO:042493	6.7	MMP7, VEGFC, MYC, PARK7, SOD1, BCL2
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.2	NFKB1, CTNNB1, TP53, IL2, TRAF6, HIF1A

Molecular functions related to laryngeal carcinoma according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase binding	GO:019901	10.2	TRAF6, TP53, PTEN, PTK2, HIF1A, STAT3
2	nitric-oxide synthase regulator activity	GO:030235	9.8	EGFR, ESR1, AKT1, HSP90AB1
3	transmembrane signaling receptor activity	GO:004888	9.6	TLR4, TLR3, TLR2, EGFR, ERBB2, ICAM1
4	identical protein binding	GO:042802	9.5	FLT1, GSTM3, AKT1, ESR1, ERBB2, TP53
5	protein heterodimerization activity	GO:046982	9.2	ERBB2, TP53, TERF1, EGFR, HIF1A, TWIST1
6	protein homodimerization activity	GO:042803	9.0	GSTM3, ENG, TERF1, TERT, PTGS2, NOS2
7	enzyme binding	GO:019899	8.9	PTGS2, CTNNB1, EGFR, HIF1A, TGFB1, ECM1
8	growth factor activity	GO:008083	7.9	TGFA, EGF, IL4, IL2, IL10, GRN
9	cytokine activity	GO:005125	7.2	EDN1, TNFSF9, IFNG, IL4, IL2, IL18
10	protein binding	GO:005515	3.7	MAP1LC3A, ERBB2, HLA-A, TRAF6, TP53, TNFRSF6B