MCID: LRY016
MIFTS: 63

Laryngeal Carcinoma malady

Cancer diseases, Oral diseases categories

Summaries for Laryngeal Carcinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Laryngeal cancer may also be called cancer of the larynx or laryngeal carcinoma. Most laryngeal cancers... more...

MalaCards: Laryngeal Carcinoma, also known as carcinoma of larynx, is related to nasopharynx carcinoma and esophageal cancer. An important gene associated with Laryngeal Carcinoma is NME1 (NME/NM23 nucleoside diphosphate kinase 1), and among its related pathways are Validated targets of C-MYC transcriptional activation and CDK-mediated phosphorylation and removal of Cdc6. The compounds vegf and progesterone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, endothelial and thyroid, and related mouse phenotypes are cellular and mortality/aging.

Aliases & Classifications for Laryngeal Carcinoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Oral diseases


Aliases & Descriptions:

laryngeal carcinoma 8 42 10 44
carcinoma of larynx 8 60
laryngeal cancer 42 44
malignant neoplasm of larynx 60
malignant neoplasms 60
cancer of larynx 8


External Ids:

Disease Ontology8 DOID:2600
NCIt39 C4855
ICD1025 C32

Related Diseases for Laryngeal Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Laryngeal Benign Neoplasm family:

laryngeal carcinoma

Diseases related to Laryngeal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 741)
idRelated DiseaseScoreTop Affiliating Genes
1nasopharynx carcinoma30.9GSTT1, TP53, NME1, PCNA, VEGFC
2esophageal cancer30.8TP53, NME1, MMP14, PCNA, VEGFC, IFI27
3oral cavity cancer30.7TP53
4laryngeal squamous cell carcinoma30.6GSTT1, TP53, BIRC5, NME1, EIF4E, PCNA
5squamous cell carcinoma30.6NME1, EIF4E, MKI67, CCND1
6stomach cancer30.6TP53
7hepatocellular carcinoma30.6GSTT1, TP53, ENG, SERPINB5, BIRC5, NME1
8leukemia30.6GSTT1, TP53, ENG, BIRC5, NME1, EIF4E
9parathyroid carcinoma30.5MKI67, CCND1
10acute leukemia30.4GSTT1, BIRC5
11papilloma30.4TP53, ENG, PCNA, BAK1, IFI27
12gallbladder cancer30.4NME1, PCNA, MKI67, IFI27
13osteosarcoma30.4TP53, BIRC5, NME1, MMP14
14thyroid cancer30.3GSTT1, TP53, SERPINB5, VEGFC, CCND1
15brain cancer30.3CP, TP53, BIRC5, MMP14, EIF4E
16prostate cancer30.2GSTT1, SERPINB5, BIRC5, NME1, MMP14, PCNA
17gastrointestinal stromal tumor30.2PCNA, MKI67, IFI27
18neuroblastoma30.2TP53, NME1
19cholangiocarcinoma30.1TP53, EIF4E, VEGFC
20myeloid leukemia30.1BIRC5, NME1
21endometrial carcinoma30.1TP53, SERPINB5, CTSD, IFI27
22breast cancer30.1SERPINB5, CTSD, CTTN, AURKA, IFI27, CCND1
23hepatoblastoma30.1BIRC5
24lung cancer30.1TP53, BIRC5, NME1, MMP14, EIF4G1, PCNA
25ovarian cancer30.0TP53, ENG, SERPINB5, BIRC5, NME1, MMP14
26kidney cancer30.0GSTT1, ENG, BIRC5, NME1, PCNA, MKI67
27burkitt's lymphoma30.0CP, TP53, BIRC5, EIF4E, MKI67, BAK1
28colon cancer30.0TP53, ENG, BIRC5, NME1, MMP14, EIF4E
29bladder carcinoma30.0GSTT1, TP53, SERPINB5, BIRC5, MKI67, AURKA
30keratoacanthoma30.0NME1, PCNA, MKI67, BAK1
31non-hodgkin lymphoma30.0GSTT1, CP, BIRC5, BAK1, CCND1
32multiple myeloma30.0TP53, CCND1
33b-cell chronic lymphocytic leukemia30.0TP53, BIRC5, BAK1, CCND1
34cervical adenocarcinoma30.0NME1, IFI27
35angiosarcoma30.0VEGFC
36chronic myeloid leukemia30.0ENG, BIRC5, NME1, EIF4E
37meningioma30.0PCNA, MKI67
38lung small cell carcinoma30.0GSTT1, TP53, VEGFC, CTSD
39adenocarcinoma29.9GSTT1, TP53, ENG, SERPINB5, BIRC5, NME1
40melanoma29.9GSTT1, CP, TP53, ENG, SERPINB5, BIRC5
41retinoblastoma29.9TP53, BIRC5, NME1, PCNA, MKI67, BAK1
42sarcoma29.9TP53, ENG, SERPINB5, MKI67
43inverted papilloma29.9PCNA, MKI67, IFI27
44pancreatic cancer29.9ENG, SERPINB5, BIRC5, PCNA
45bone carcinoma29.9SERPINB5, MMP14, CTSD
46leiomyosarcoma29.9TP53
47vascular disease29.9TP53, PCNA
48colon adenocarcinoma29.9EIF4E
49cervical cancer29.9GSTT1, TP53, BIRC5, NME1, MMP14, PCNA
50glioblastoma multiforme29.8TP53, ENG, BIRC5, MMP14, EIF4E, PCNA

Graphical network of the top 20 diseases related to Laryngeal Carcinoma:



Diseases related to laryngeal carcinoma

Clinical Features for Laryngeal Carcinoma

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Drugs & Therapeutics for Laryngeal Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Laryngeal Carcinoma

Drug clinical trials:

Search ClinicalTrials for Laryngeal Carcinoma

Search NIH Clinical Center for Laryngeal Carcinoma

Search CenterWatch for Laryngeal Carcinoma

Genetic Tests for Laryngeal Carcinoma

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Anatomical Context for Laryngeal Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Laryngeal Carcinoma:

32
Lymph node, Endothelial, Thyroid, Lung, Skin, Pituitary, T cells, Breast, Colon, Prostate, Testes, Monocytes, Small intestine, Heart, Bone

Animal Models for Laryngeal Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Laryngeal Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.3CP, CCND1, AURKA, CTTN, CTSD, BAK1
2MP:001076811.2VEGFC, CTSD, CTTN, AURKA, CCND1, BAK1
3MP:000538711.0CCND1, CTTN, CTSD, VEGFC, BAK1, PCNA
4MP:000539711.0CTSD, BAK1, PCNA, NME1, BIRC5, ENG
5MP:000537610.6CTSD, MMP14, CP, GSTT1
6MP:000538010.4CTTN, MMP14, SERPINB5, ENG

Publications for Laryngeal Carcinoma

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Sources:
50PubMed
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Articles related to Laryngeal Carcinoma:

(show top 50)    (show all 1311)
idTitleAuthorsYear
1
Annexin A1, A2, A4 and A5 play important roles in breast cancer, pancreatic cancer and laryngeal carcinoma, alone and/or synergistically. (23255903)
2013
2
Expression of astrocyte elevated gene-1 protein and its clinical significance in laryngeal squamous cell carcinoma]. (23710918)
2013
3
Comprehensive analysis of HPV expression in laryngeal squamous cell carcinoma. (24374907)
2013
4
Reduced E-cadherin expression is associated with lymph node metastases in laryngeal squamous cell carcinoma. (21570223)
2012
5
Are laryngeal squamous cell carcinoma incidence and patient mortality a function of ABO blood grouping? A retrospective study. (22018244)
2012
6
Expression of matrix metalloproteinase-1, E26 transformation-specific-1 in laryngeal carcinoma tissue and the clinical significance]. (22390030)
2011
7
Expression of ABC transporters is an unfavorable prognostic factor in laryngeal squamous cell carcinoma. (22279954)
2011
8
Down-regulation of cyclin D1 by small interfering RNA inhibits cell growth and induces apoptosis of laryngeal squamous cell carcinoma. (21315488)
2011
9
Laryngeal keratosis with underlying invasive carcinoma. (21174272)
2010
10
Survival after laryngectomy: a review of 133 patients with laryngeal carcinoma. (19921233)
2010
11
Sinonasal and laryngeal carcinoma in children: correlation of imaging characteristics with clinicopathologic and cytogenetic features. (19779003)
2010
12
Adhesion/growth-regulatory tissue lectin galectin-1 in relation to angiogenesis/lymphocyte infiltration and prognostic relevance of stromal up-regulation in laryngeal carcinomas. (19331133)
2009
13
Selective (intra-arterial), rapid infusion chemo-radiotherapy to preserve the larynx in advanced laryngeal carcinoma: preliminary results. (19848000)
2009
14
Differential gene expression profiling of laryngeal squamous cell carcinoma by laser capture microdissection and complementary DNA microarrays. (19237021)
2009
15
The effect of treatment on survival in patients with advanced laryngeal carcinoma. (19444887)
2009
16
Loss of imprinting of IGF2 and H19, loss of heterozygosity of IGF2R and CTCF, and Helicobacter pylori infection in laryngeal squamous cell carcinoma. (18604514)
2008
17
Sex hormone receptor levels in laryngeal carcinoma: a comparison between protein and RNA evaluations. (18246362)
2008
18
Effect of RNA interference mediated gene silencing of DJ-1 on proliferation of laryngeal carcinoma cell line Hep-2]. (18717316)
2008
19
Laryngeal squamous cell carcinoma metastatic to a flank intramuscular lipoma. (18481507)
2008
20
The relationship between the extracellular matrix and the angiogenesis and metastasis of laryngeal carcinoma. (18984970)
2008
21
Intralesional cidofovir does not increase the risk of laryngeal dysplasia or laryngeal carcinoma. (18602168)
2008
22
Construction siRNA expressing vector of Skp2 and the inhibitory effects on the expression of Skp2 in laryngeal carcinoma cell line Hep2 cell]. (19166034)
2008
23
Laminin expression in advanced laryngeal squamous cell carcinoma does not correlate to neck metastases. (18516614)
2008
24
Combined modality treatment of laryngeal squamous cell carcinoma. (17338653)
2007
25
Laryngeal carcinoma: five-year survival and patterns of failure in 202 consecutive patients treated with primary or post-operative radiotherapy in Hong Kong. (16696880)
2006
26
Maspin nuclear localization is related to reduced density of tumour-associated micro-vessels in laryngeal carcinoma. (17214364)
2006
27
Molecular assessment of neck dissections supports preserving level IIB lymph nodes in selective neck dissection for laryngeal squamous cell carcinoma with a clinically negative neck. (16465073)
2006
28
Expression of integrin-linked kinase is closely correlated with laryngeal squamous cell carcinomas]. (16836071)
2006
29
Overexpression of MMP-2 in laryngeal squamous cell carcinoma: a potential indicator for poor prognosis. (15746850)
2005
30
The expression and role of VEGF-C and its receptor FLT-4 in laryngeal and hypopharyngeal squamous cell carcinoma metastasis]. (16375119)
2005
31
Expression of six gene proteins in laryngeal carcinomas and their significance]. (16248464)
2005
32
Anterior vocal commissure invasion in laryngeal carcinoma diagnosis. (15805888)
2005
33
Expression and significance of PTEN and caspase-3 in laryngeal squamous cell carcinoma]. (15831044)
2004
34
Role of 11-C-methionine positron emission tomography for the delineation of the tumor volume in pharyngo-laryngeal squamous cell carcinoma: comparison with FDG-PET and CT. (15172141)
2004
35
c-met overexpression in supraglottic laryngeal squamous cell carcinoma and its relation to lymph node metastases. (15195055)
2004
36
p53, Ki67 and cyclin D1 as prognosticators of lymph node metastases in laryngeal carcinoma. (14551784)
2003
37
DNA ploidy status as a prognostic marker and predictor of lymph node metastasis in laryngeal carcinoma. (12450177)
2002
38
Prognostic significance of CD44v6 and nm23 protein immunoexpression in laryngeal squamous cell carcinoma. (12014221)
2002
39
p73 gene alterations and expression in primary oral and laryngeal squamous carcinomas. (11323391)
2001
40
Laryngeal carcinoma--epidemiological and clinical features: experience of the Rabin Medical Center in Israel. (11115586)
2001
41
Association of vascular endothelial growth factor and mast cells with angiogenesis in laryngeal squamous cell carcinoma. (10782883)
2000
42
Correlation of tumor markers p53, bcl-2 and cathepsin-D with clinicopathologic features and disease-free survival in laryngeal squamous cell carcinoma. (11012985)
2000
43
FHIT gene is abnormal in laryngeal carcinoma]. (11776620)
1999
44
Biological characterization of laryngeal squamous-cell carcinoma. (8694553)
1996
45
Methotrexate removal during haemodialysis in a patient with advanced laryngeal carcinoma. (8823500)
1996
46
Eosinophilic infiltration in advanced laryngeal squamous cell carcinoma. Veterans Administration Laryngeal Cooperative Study Group. (7715387)
1995
47
Laryngeal carcinoma--a relationship to tobacco and alcohol use. (7723008)
1995
48
Tumor response, toxicity, and survival after neoadjuvant organ-preserving chemotherapy for advanced laryngeal carcinoma. The Department of Veterans Affairs Cooperative Laryngeal Cancer Study Group. (8040671)
1994
49
The treatment of primary recurrence following laryngectomy for laryngeal carcinoma. (15125279)
1993
50
Hypertrophic pulmonary osteoarthropathy and tripe palms in a man with squamous cell carcinoma of the larynx and lung. Report of a case and review of cutaneous paraneoplastic syndromes associated with laryngeal and lung malignancies. (8338062)
1993

Genetic Variations for Laryngeal Carcinoma

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Expression for genes affiliated with Laryngeal Carcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Laryngeal Carcinoma

Search GEO for disease gene expression data for Laryngeal Carcinoma.

Pathways for genes affiliated with Laryngeal Carcinoma

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Sources:
37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology, 29KEGG, 12EMD Millipore, 52R&D Systems, 51QIAGEN
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Pathways related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7TP53, BIRC5, NME1, EIF4G1, EIF4E
2
Hide members
10.7CCND1, AURKA, BAK1, PCNA, EIF4G1
310.7CTSD, BAK1, PCNA, SERPINB5, TP53
410.7CTSD, BAK1, BIRC5, SERPINB5
510.7TP53, SERPINB5, BAK1, CCND1
610.7TP53, NME1, PCNA, CCND1
710.7CCND1, AURKA, BAK1, TP53
8
Hide members
10.7PCNA, MKI67, AURKA, CCND1
9
Hide members
10.7TP53, BIRC5, PCNA, CCND1
10
Hide members
10.7TP53, BIRC5, PCNA, CCND1
1110.6ENG, SERPINB5, VEGFC
12
Hide members
10.6CCND1, SERPINB5, TP53
1310.6TP53, SERPINB5, CTSD
1410.6CCND1, CTTN, NME1
1510.6AURKA, BIRC5, TP53
1610.6EIF4E, EIF4G1, TP53
1710.6TP53, PCNA, CCND1
1810.6CCND1, PCNA, TP53
19
Hide members
10.6CCND1, PCNA, TP53
20
Apoptosis and survival Apoptotic TNF-family pathways
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10.6TP53, BIRC5, BAK1
2110.6BIRC5, MMP14
22
Hide members
10.6EIF4G1, EIF4E
23
Hide members
10.5AURKA

Compounds for genes affiliated with Laryngeal Carcinoma

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1vegf4411.7CCND1, PCNA, CP, TP53, ENG, CTSD
2progesterone44 59 28 11 2415.7VEGFC, MKI67, PCNA, EIF4E, EIF4G1, MMP14
3paraffin4411.6TP53, ENG, BIRC5, NME1, MMP14, PCNA
4cisplatin44 49 59 1114.6TP53, BIRC5, CCND1, IFI27, CTSD, BAK1
5oxygen44 2412.5GSTT1, MMP14, EIF4E, MKI67, BAK1, VEGFC
6retinoic acid44 2412.5CCND1, CTSD, VEGFC, MKI67, PCNA, EIF4E
7oligonucleotide4411.5TP53, CCND1, BIRC5, EIF4E, MMP14, NME1
8thymidine44 2412.4PCNA, MKI67, VEGFC, BIRC5, CTSD, IFI27
9p0024411.4BIRC5, SERPINB5, ENG, NME1, MMP14, MKI67
10doxorubicin44 49 1113.4MKI67, ENG, BIRC5, TP53, GSTT1, BAK1
11agar4411.3CCND1, EIF4E, CTSD, NME1, BIRC5, ENG
12testosterone44 59 11 2414.3CTSD, IFI27, CCND1, PCNA, VEGFC, SERPINB5
13steroid4411.3MKI67, GSTT1, SERPINB5, BIRC5, NME1, EIF4E
14pd 98,0594411.3IFI27, BIRC5, EIF4E, CTTN, EIF4G1, MMP14
15ly2940024411.3TP53, BIRC5, MMP14, EIF4G1, EIF4E, VEGFC
16tyrosine4411.3BIRC5, NME1, MMP14, EIF4E, MKI67, BAK1
17paclitaxel44 49 1113.3CCND1, IFI27, AURKA, CTSD, BAK1, BIRC5
18phosphatidylinositol4411.3EIF4G1, EIF4E, BAK1, VEGFC, BIRC5, CTSD
19serine4411.3EIF4E, CTTN, AURKA, CCND1, NME1, MMP14
20threonine4411.3MMP14, EIF4E, MKI67, CTTN, IFI27, AURKA
21mg 13244 5912.2IFI27, CCND1, EIF4E, PCNA, EIF4G1, BIRC5
22lactate4411.2CP, IFI27, CTSD, BIRC5, NME1, MMP14
23alanine4411.2PCNA, BAK1, CTSD, BIRC5, EIF4E, NME1
24dexamethasone44 49 28 1114.2BIRC5, NME1, MMP14, PCNA, BAK1, IFI27
255fluorouracil4411.2CTSD, PCNA, NME1, BIRC5, TP53, MKI67
26dutp4411.2BAK1, TP53, BIRC5, PCNA, MKI67, CCND1
27adpribose4411.2TP53, BIRC5, BAK1, IFI27, CCND1, PCNA
28norcantharidin4411.2IFI27, CCND1, MKI67, BIRC5, PCNA
29tamoxifen44 49 28 1114.1SERPINB5, CTSD, CCND1, MKI67, BIRC5
30thymidylate4411.1CCND1, BIRC5, MKI67, IFI27, PCNA, TP53
31cysteine4411.1ENG, MMP14, CP, PCNA, BAK1, CTSD
32p000014411.1MMP14, MKI67, VEGFC, CCND1, BIRC5
33etoposide44 49 59 1114.1CTSD, EIF4G1, EIF4E, BAK1
34estradiol44 11 2413.1CTSD, BIRC5, VEGFC, BAK1, MKI67
35sulindac44 1112.1CCND1, BIRC5, PCNA, TP53, IFI27
36roscovitine4411.1IFI27, CCND1, PCNA, BIRC5, TP53
37matrigel4411.1CTTN, NME1, SERPINB5, CCND1
38arsenite44 2412.0PCNA, EIF4E, EIF4G1, TP53, BIRC5, CCND1
39trastuzumab44 49 1113.0CCND1, IFI27, CTSD, VEGFC, BIRC5
40chi 24411.0IFI27, NME1, MKI67, GSTT1
41celecoxib44 59 28 49 11 2416.0BIRC5, PCNA, CCND1, MKI67, BAK1
42nitric oxide44 11 2412.9EIF4E, CTSD, VEGFC, NME1, BIRC5, SERPINB5
43nimbolide4410.9BIRC5, PCNA, CCND1
44n acetylcysteine4410.9TP53, CCND1, IFI27, BIRC5, PCNA, EIF4E
45lycopene44 2411.9CP, CCND1, IFI27, PCNA
46crcs4410.8CCND1, NME1, BIRC5, TP53
47ascorbic acid44 2411.8CP, ENG, PCNA, CTSD, GSTT1
48bromodeoxyuridine4410.7MMP14, PCNA, CCND1, MKI67, IFI27
49indole-3-carbinol4410.6CCND1, IFI27, BIRC5, TP53
50p0054410.3SERPINB5, MKI67, ENG

GO Terms for genes affiliated with Laryngeal Carcinoma

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Sources:
16Gene Ontology
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Cellular components related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582910.7GSTT1, CCND1, AURKA, BAK1, EIF4E, EIF4G1
2eukaryotic translation initiation factor 4F complexGO:01628110.6EIF4G1, EIF4E

Biological processes related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1organ regenerationGO:03110010.7MKI67, BAK1, CCND1
2extracellular matrix disassemblyGO:02261710.6ENG, MMP14, CTSD
3regulation of mitochondrial membrane permeabilityGO:04690210.6TP53, BAK1
4mitotic G1 DNA damage checkpointGO:03157110.5CCND1, TP53
5response to drugGO:04249310.4GSTT1, BAK1, VEGFC, CCND1

Molecular functions related to Laryngeal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.3TP53, CCND1, AURKA, CTTN, CTSD, VEGFC
2protein kinase bindingGO:01990110.7TP53, NME1, AURKA, CCND1
3chaperone bindingGO:05108710.6BAK1, BIRC5, TP53, CP
4identical protein bindingGO:04280210.4BAK1, PCNA, NME1, BIRC5, TP53

Products for genes affiliated with Laryngeal Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Laryngeal Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet