Laryngeal Squamous Cell Carcinoma malady

MalaCards: Laryngeal Squamous Cell Carcinoma, also known as squamous cell carcinoma of larynx (disorder), is related to squamous cell carcinoma and basaloid squamous cell carcinoma. An important gene associated with Laryngeal Squamous Cell Carcinoma is SKP2 (S-phase kinase-associated protein 2, E3 ubiquitin protein ligase), and among its related pathways are Signal transduction_PTEN pathway and Cell Cycle / Checkpoint Control. The drugs bleomycin and bleomycin sulfate and the compounds phosphatidylserine and vincristine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, t cells and b cells, and related mouse phenotypes are respiratory system and craniofacial.

Aliases & Descriptions:

laryngeal squamous cell carcinoma 6 8 32 43 squamous cell carcinoma of larynx (disorder) 6

epidermoid carcinoma of the larynx 6 squamous cell carcinoma 43

Diseases related to laryngeal squamous cell carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 866)

id	Related Disease	Score	Top Affiliating Genes
1	squamous cell carcinoma	43.4	RBP1, LGALS1, LGALS3, LGALS8, CD44, CDH1
2	basaloid squamous cell carcinoma	36.9	PCNA, MYC, BIRC5, BAX, CDKN2A, CDH1
3	keratoacanthoma	36.4	PCNA, RBP1, BCL2, MSH2, CDKN1A, CD44
4	basal cell carcinoma	36.4	BCL2, LGALS1, LGALS3, BAX, S100A2, CD44
5	keratosis	36.2	PCNA, RB1, MYC, BCL2, S100A2, CFLAR
6	actinic keratosis	35.8	PCNA, RB1, MYC, BCL2, S100A2, CFLAR
7	maxillary sinus squamous cell carcinoma	34.9	PCNA, VEGFA, BAX, CDKN1A, GSTP1, FGF2
8	cervical squamous cell carcinoma	34.7	BSG, MYC, BIRC5, BCL2, BAX, CDKN1A
9	teratoma	34.4	PCNA, BCL2, BAX, CDKN2A, CDKN3, CDH1
10	xeroderma pigmentosum	34.1	RECQL4, PCNA, BCL2, BAX, CDKN2A, CDK4
11	inverted papilloma	34.0	PCNA, FSCN1, MKI67, IFI27, KRT13
12	squamous cell carcinoma of the head and neck	33.7	PCNA, VEGFA, VEGFC, MYC, BCL2, LGALS1
13	lichen sclerosus	33.6	CDKN2A, CD44, FAS, CCND1, TP53, PTGS2
14	leukoplakia	33.5	PCNA, NAT2, BCL2, BAG1, BAX, MSH2
15	adenosquamous carcinoma	33.5	FHIT, TP63, CTSD, KRT19, EGFR, TYMP
16	esophageal squamous cell carcinoma	33.3	PIM1, SFN, PCNA, PCDH17, RB1, RBP1
17	verrucous carcinoma	33.3	PCNA, RB1, CDKN1A, CDKN2A, CD44, CDH1
18	pharyngitis	33.1	PCNA, NAT2, VEGFA, BCL2, FSCN1, CD36
19	epidermolysis bullosa	32.9	CD36, CDKN2A, MMP1, MMP13, FGF2, TP53
20	tongue cancer	32.9	VEGFC, LGALS1, CDKN1A, CDH1, MMP2, MMP9
21	cervical intraepithelial neoplasia	32.8	PCNA, RB1, RBP1, VEGFA, VEGFC, BIRC5
22	small cell carcinoma	32.7	PCNA, RB1, VEGFA, BCL2, BAX, CDKN2A
23	actinic cheilitis	32.5	BAX, MSH2, CDKN1A, MMP9, MKI67, TP53
24	dna topoisomerase ii	32.4	PCNA, MYC, CDKN1A, CDK2, MKI67, GSTP1
25	oral squamous cell carcinoma	32.2	PIM1, SFN, PCNA, RB1, BSG, VEGFA
26	esophagus adenocarcinoma	32.1	BCL2, CDKN1A, CDKN2A, MKI67, CCND1, TP53
27	cheilitis	32.0	BAX, MSH2, CDKN1A, MMP9, MKI67, TP53
28	fanconi's anemia	31.8	PCNA, RB1, BLZF1, BCL2, MUS81, MSH2
29	pituitary tumor	31.6	PCNA, RB1, VEGFA, MYC, BIRC5, LGALS3
30	lung occult squamous cell carcinoma	31.6	PCNA, BCL2, S100A2, S100A4, AURKA, CDKN1A
31	adenoid cystic carcinoma	31.5	PCNA, LGALS3, CDH1, MKI67, CCND1, ERBB3
32	tonsillitis	31.4	VEGFA, CLU, BCL2, MTA1, CDKN2A, CD44
33	esophagitis	31.4	PIM1, SFN, PCNA, PCDH17, RB1, RBP1
34	oral lichen planus	31.4	BAX, MMP1, HSPA4, CASP3, TP63
35	merkel cell carcinoma	31.4	PCNA, VEGFC, BIRC5, BCL2, BAX, CDKN1A
36	large cell carcinoma	31.3	CDK2, CDK4, ENO2, ERBB2, TP63, EGFR
37	basaloid squamous cell skin carcinoma	31.3	CDH1, CASP3, TP53, TP63, EGF, EIF4E
38	skin melanoma	31.0	PCNA, CDKN1A, CD36, CDKN2B, CDKN2A, MMP2
39	trichoepithelioma	30.8	BCL2, CDKN2B, CDH1, MKI67, PDPN, KRT19
40	anaplastic carcinoma	30.7	LGALS1, LGALS3, S100A4, CDH1, FHIT, ENO2
41	angiosarcoma	30.6	VEGFA, VEGFC, MYC, FSCN1, CDKN2A, CDKN3
42	papilloma	30.6	PCNA, RB1, VEGFA, BIRC5, BCL2, BAX
43	neuroendocrine carcinoma	30.5	FSCN1, CDH1, FHIT, ENO2, TP63, KRT19
44	intraepithelial neoplasm	30.4	PCNA, CDKN2A, MKI67, ERBB2, TP53, KRT13
45	pleomorphic carcinoma	30.2	FSCN1, CAV1, TP53, PDPN, EGFR, CSF3
46	epithelioid sarcoma	30.0	BSG, MET, CCND1, TP63, EGFR, CSF3
47	chronic lymphocytic leukemia	30.0	BLZF1, BIRC5, BIRC7, BCL10, BCL2, ZAP70
48	nasopharynx carcinoma	30.0	VEGFA, CDKN2A, CDH1, MMP9, CCND1, CASP3
49	lichen planus	30.0	PCNA, VEGFA, BCL2, BAX, CDKN2A, CDK4
50	mucoepidermoid carcinoma	29.9	PCNA, MKI67, TP63, CTNNA1, NOS2, KRT13

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 bleomycin, bleomycin sulfate

MalaCards organs/tissues related to laryngeal squamous cell carcinoma:

²²

MGI Mouse Phenotypes related to laryngeal squamous cell carcinoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.8	TP63
2	craniofacial phenotype	MP:0005382	10.4	RECQL4, ITGB8, MMP20, ILK, APAF1, CASP9
3	endocrine/exocrine gland phenotype	MP:0005379	10.2	SFN, CDKN2B, AQP1, APAF1, FASLG, CCNA1
4	liver/biliary system phenotype	MP:0005370	10.0	SFN, RBP1, VEGFA, BAG1, CD36, FOXM1
5	immune system phenotype	MP:0005387	9.6	RECQL4, SFN, RBP1, BSG, BMF, RAF1
6	renal/urinary system phenotype	MP:0005367	9.5	CLU, BCL2, BAX, CFL1, CDKN1A, CDKN2B
7	pigmentation phenotype	MP:0001186	9.3	RECQL4, RB1, RBP1, MYC, BCL2, CDKN2A
8	normal phenotype	MP:0002873	9.2	VEGFA, MYC, BMF, LGALS1, ZAP70, S100A4
9	other phenotype	MP:0005395	9.1	CLU, CDKN2A, ITGB8, MMP14, FN1, IL13
10	no phenotypic analysis	MP:0003012	9.1	PCNA, RB1, VEGFA, MYC, BMF, MTHFR
11	embryogenesis phenotype	MP:0005380	9.0	RECQL4, SFN, MYC, RAF1, BIRC5, BCL10
12	hematopoietic system phenotype	MP:0005397	8.9	PIM1, RECQL4, SFN, PCNA, RBP1, BMF
13	hearing/vestibular/ear phenotype	MP:0005377	8.6	SFN, RB1, RBP1, MYC, BCL2, BAX
14	adipose tissue phenotype	MP:0005375	8.3	RB1, MYC, BCL2, CDKN1A, CD36, FLT4
15	limbs/digits/tail phenotype	MP:0005371	8.2	RECQL4, SFN, RB1, VEGFA, BMF, BAX
16	mortality/aging	MP:0010768	7.8	RECQL4, SFN, RB1, BSG, VEGFA, VEGFC
17	behavior/neurological phenotype	MP:0005386	7.6	RB1, PARK7, LGALS1, LGALS8, CFL1, CDKN1A
18	tumorigenesis	MP:0002006	7.3	RECQL4, SFN, RB1, MYC, BMF, BCL2
19	reproductive system phenotype	MP:0005389	7.1	SFN, RBP1, VEGFA, BMF, MUS81, BAD
20	integument phenotype	MP:0010771	7.1	RECQL4, SFN, RB1, MYC, RAF1, BCL2
21	skeleton phenotype	MP:0005390	6.5	SFN, RB1, VEGFA, MYC, RAF1, LGALS3
22	digestive/alimentary phenotype	MP:0005381	6.5	RECQL4, SFN, RB1, VEGFA, MYC, BCL2
23	vision/eye phenotype	MP:0005391	6.3	RECQL4, SFN, RB1, RBP1, VEGFA, RAF1
24	growth/size phenotype	MP:0005378	6.1	PIM1, RECQL4, SFN, RB1, RBP1, BSG
25	nervous system phenotype	MP:0003631	6.0	RB1, RBP1, MYC, RAF1, BCL10, LGALS1
26	muscle phenotype	MP:0005369	5.0	RB1, VEGFA, MYC, RAF1, CLU, BCL2
27	cardiovascular system phenotype	MP:0005385	4.6	RB1, VEGFA, VEGFC, MYC, RAF1, CLU
28	homeostasis/metabolism phenotype	MP:0005376	4.5	RB1, RBP1, NAT2, VEGFA, VEGFC, MYC
29	cellular phenotype	MP:0005384	3.9	PIM1, RECQL4, SFN, PCNA, RB1, VEGFA

Articles related to laryngeal squamous cell carcinoma:

(show top 50)    (show all 256)

id	Title	Authors	Year	Affiliating Genes
1	Aurora B kinase expression in laryngeal squamous cell carcinoma and its prognostic implications. (21299608)	GarcA-a-FernA!ndez E.... Hardisson D.	2011	AURKB
2	Expression and significance of integrins subunits in laryngeal squamous cell carcinoma]. (20942236)	Ni R.... Gao X.	2010	ITGAV, ITGA8, ITGB8
3	Protein expression of epidermal growth factor recepto r in laryngeal squamous cell carcinoma index tumors correlates with diagnosis o f second primary tumors of the upper aero-digestive tract. (19669840)	Farhadieh R.D.... Smee R.	2009	EGFR
4	Mutant p53 and cyclin A1 protein expression in primary laryngeal squamous cell carcinomas do not correlate to second primary tumours of the head and neck. (19183379)	Farhadieh R.D.... Russell P.J.	2009	TP53, CCNA1
5	p53, epidermal growth factor receptor and proliferating cell nuclear antigen in laryngeal squamous cell carcinoma are not predictive markers for the effect of adjuvant radiotherapy. (18607952)	Jiang H.... Yang B.B.	2009	EGFR, TP53, PCNA
6	The expression of Galectin-3 and VEGF in laryngeal squamous cell carcinoma (19452726)	Kong H.... Dong Z.	2009	VEGFA, LGALS3
7	Gene expression profiling reveals molecular marker candidates of laryngeal squamous cell carcinoma. (19212623)	Colombo J.... Rahal P.	2009	CSTB
8	Expression of cyclin G1 in laryngeal squamous cell carcinoma and its clinicopathologic significance (18788592)	Cui X.F.... Chen X.G.	2008	TP53, CCNG1
9	Expression of stathmin mRNA and protein in laryngeal squamous cell carcinoma and its clinical implication (18666697)	Zhang C.Y.... Huang B.Y.	2008	STMN1
10	Expression of Survivin, Caspase-3 and p53 in surgical margin of laryngeal squamous cell carcinoma and their relationship (18476631)	Du J.... Su Y.	2008	TP53, CASP3, BIRC5
11	Rationale for adjuvant fatty acid therapy to prevent radiotherapy failure and tumor recurrence during early laryngeal squamous cell carcinoma. (18054475)	Louw L.... Claassen J.	2008	PTGS2
12	Expression and clinical significance of hypoxia-inducible factor-1alpha and angiopoietin-2 in laryngeal squamous cell carcinoma (18727515)	Li P.... Zhao L.	2008	HIF1A, ANGPT2
13	The expressions and significance of CK2 in normal laryngeal mucosa, laryngeal precancerosis and laryngeal squamous cell carcinoma (18062282)	Wu L.... Liu B.	2007	CSNK2A1, CSNK2B
14	Expression and role of survivin in laryngeal squamous cell carcinoma and laryngeal papilloma in adults (17634026)	Xie H.... Song F.	2007	BIRC5
15	Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad, Bmf and Bcl-G in laryngeal squamous cell carcinomas. (17557568)	Yoo N.J.... Lee S.H.	2007	BCL2, BAD, BMF
16	Overexpression of transketolase TKTL1 is associated with shorter survival in laryngeal squamous cell carcinomas. (17639446)	Volker H.U.... Eck M.	2007	TKTL1, TKTL2
17	Down-regulation of zeta chain and zeta-associated protein 70 (Zap 70) expression in circulating T lymphocytes in laryngeal squamous cell carcinoma. (17375875)	Pignataro L.... Corsi M.M.	2007	ZAP70
18	The relationship between the activation of ERK and the up-regulation of uPA in laryngeal squamous cell carcinoma (17634019)	Wang D.W.... Ren Z.	2007	MAPK3, MAPK1, PLAU
19	Expression and significance of TGF-beta1 and HSP70 in human laryngeal squamous cell carcinoma (17802821)	Yang S.... Li Y.	2007	TGFB1, HSPA4
20	Expression and prognostic significance of cyclooxygenase-2 in supraglottic laryngeal squamous cell carcinomas (18330256)	Li J.... Pan Z.	2007	PTGS2
21	Inhibited effects of exogenous caveolin-1 on the growth of laryngeal squamous cell carcinoma cell line Hep-2, experiments in vitro and in vivo (17629009)	Gu D.H.... Zhu H.G.	2007	MAPK3, CAV1
22	Expression and significance of ErbB3 and ErbB4 in patients with laryngeal squamous cell carcinomas (17969526)	Ming W.... Zhang D.	2007	ERBB4, ERBB3
23	5-fluorouracil mediates apoptosis and G1/S arrest in laryngeal squamous cell carcinoma via a p53-independent pathway. (17207318)	Liu H.C.... van Hasselt C.A.	2006	TP53
24	The correlation of vascular endothelial growth factor with angiogenesis and p53 gene in laryngeal squamous cell carcinoma (16763427)	Yaylaci A.... GAPkAseer T.	2006	TP53, VEGFA
25	Growth suppression of human laryngeal squamous cell carcinoma by adenovirus-mediated tissue factor pathway inhibitor gene 2. (16585865)	Sun Y.... Li P.	2006	TFPI2
26	Expression and biological significance of survivin and p63 in laryngeal squamous cell carcinoma (16375115)	Wen X.... Ji W.	2005	BIRC5, TP63
27	Cyclin D3 immunoreactivity is an independent predictor of survival in laryngeal squamous cell carcinoma. (15671552)	Pruneri G.... Viale G.	2005	CCND3
28	Prognostic significance of Jab1 expression in laryngeal squamous cell carcinomas. (15671554)	Dong Y.... Tokuda M.	2005	COPS5
29	Human telomerase reverse transcriptase expression and its clinical significance in laryngeal squamous cell carcinoma. (15823813)	Li Y.R.... Hu L.H.	2005	TERT
30	The expression of p21(WAF1/CIP1) and PCNA in hypopharyngeal and laryngeal squamous cell carcinomas (15844604)	Li X.... Dong P.	2005	PCNA
31	Correlation of FHIT expression to cell proliferation and metastasis of laryngeal squamous cell carcinoma. (15522186)	Yin D.T.... Wang Q.Z.	2004	FHIT
32	Matrix proteoglycans are markedly affected in advanced laryngeal squamous cell carcinoma. (15196596)	Skandalis S.S.... Papageorgakopoulou N.	2004	ACAN
33	Expression of hypoxia inducible factor-1alpha and its relationship to apoptosis and proliferation in human laryngeal squamous cell carcinoma. (15791865)	Yu L.... Cui Y.	2004	HIF1A, PCNA
34	Prognostic value of PCNA and mutant p53 expression in laryngeal squamous cell carcinoma. (15199601)	Buyukbayram H.... IA9ikakdogan A.R.	2004	TP53, PCNA
35	Relationship between expression of survivin and prog nosis in human laryngeal squamous cell carcinoma (15191673)	Guan Z.... Zheng Y.Q.	2004	BIRC5
36	Serum IL-13 concentration response to surgical treatment in patients with laryngeal squamous cell carcinoma. (14756548)	Pignataro L.... Corsi M.M.	2003	IL13
37	Lack of Bcl10 gene mutations in laryngeal squamous cell carcinoma. (12389689)	Ronchetti D.... Pignataro L.	2002	BCL10
38	Aberrant expression of cyclin A in laryngeal squamous cell carcinoma. (12017338)	Dong Y.... Tokuda M.	2002	CCNA2
39	p63 in laryngeal squamous cell carcinoma: evidence for a role of TA-p63 down-regulation in tumorigenesis and lack of prognostic implications of p63 immunoreactivity. (12379767)	Pruneri G.... Viale G.	2002	TP63
40	Clinical relevance of cyclin B1 overexpression in laryngeal squamous cell carcinoma. (11809526)	Dong Y.... Tokuda M.	2002	CCNB1
41	The protein expression of p53 and bcl-2 in laryngeal squamous cell carcinoma (12600081)	Liu S.... Liang C.	2001	TP53, BCL2
42	Clinical relevance of Fas (APO-1/CD95) expression in laryngeal squamous cell carcinoma. (11443747)	JAockel M.C.... FA1zesi L.	2001	FAS
43	The role of p53 tumor suppressor gene as prognostic factor in laryngeal squamous cell carcinoma (10875157)	Garozzo A.... Allegra E.	1999	TP53
44	Prognostic significance of EGFR and p53 expression, and angiogenesis in laryngeal squamous cell carcinoma (10191626)	Watanabe H.... Miyata H.	1999	EGFR, TP53
45	Loss of retinoblastoma protein expression in laryngeal squamous cell carcinoma. (9950162)	Mizokami H.... Shin T.	1999	TP53
46	Downregulation of p21/WAF1 is related to advanced and dedifferentiated laryngeal squamous cell carcinoma. (10562812)	Hirvikoski P.... Kosma V.M.	1999	TP53, CDKN1A
47	Association between cyclin D1 (CCND1) gene amplification and human papillomavirus infection in human laryngeal squamous cell carcinoma. (9829720)	Cattani P.... Neri G.	1998	CCND1
48	Prognostic significance of methyl-p-hydroxy-phenyllactate-esterase activity in laryngeal squamous cell carcinoma. (9579830)	Maurizi M.... Ranelletti F.O.	1998	EGF
49	Significance of p16 and C-myc expression in the laryngeal squamous cell carcinoma (10323033)	Peng J.... Xu Y.	1997	MYC, CDKN2A
50	Expression of p53 protein in laryngeal squamous cell carcinoma and dysplasia: possible correlation with human papillomavirus infection and clinicopathological findings. (7850072)	Gorgoulis V.... Kittas C.	1994	TP53

Genes related to laryngeal squamous cell carcinoma according to GeneCards:

(show top 50)    (show all 184)

id	Symbol	Description	Score	GeneCards Section Context
1	SKP2	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase	11.0	Publications
2	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	11.0	Publications
3	GSTM3	glutathione S-transferase mu 3 (brain)	11.0
4	CTSD	cathepsin D	11.0	Publications
5	CCNB1	cyclin B1	11.0	Publications
6	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0	Publications
7	BIRC5	baculoviral IAP repeat containing 5	11.0	Publications
8	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
9	CCNA2	cyclin A2	11.0	Publications
10	BSG	basigin (Ok blood group)	11.0	Publications
11	TERT	telomerase reverse transcriptase	11.0	Publications
12	CCND3	cyclin D3	11.0	Publications
13	FLT4	fms-related tyrosine kinase 4	11.0	Publications
14	AURKA	aurora kinase A	11.0	Publications
15	PCNA	proliferating cell nuclear antigen	11.0	Publications
16	IFI27	interferon, alpha-inducible protein 27	11.0	Publications
17	PTEN	phosphatase and tensin homolog	11.0	Publications
18	EIF4E	eukaryotic translation initiation factor 4E	11.0	Publications
19	NME1	NME/NM23 nucleoside diphosphate kinase 1	11.0	Publications
20	MCM2	minichromosome maintenance complex component 2	11.0
21	RB1	retinoblastoma 1	11.0	Publications
22	CCND1	cyclin D1	11.0	Publications
23	CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	11.0	Publications
24	TP53	tumor protein p53	11.0	Publications
25	CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	11.0	Publications
26	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
27	NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	11.0	Publications
28	MGMT	O-6-methylguanine-DNA methyltransferase	11.0	Publications
29	CDK2	cyclin-dependent kinase 2	11.0	Publications
30	CD44	CD44 molecule (Indian blood group)	11.0	Publications
31	VEGFC	vascular endothelial growth factor C	11.0	Publications
32	BCL2	B-cell CLL/lymphoma 2	11.0	Publications
33	GSTT1	glutathione S-transferase theta 1	11.0	Publications
34	BAX	BCL2-associated X protein	11.0	Publications
35	TP63	tumor protein p63	11.0	Publications
36	TP73	tumor protein p73	11.0	Publications
37	KRT19	keratin 19	11.0
38	VEGFA	vascular endothelial growth factor A	11.0	Publications
39	GSTM1	glutathione S-transferase mu 1	11.0	Publications
40	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	11.0	Publications
41	EGFR	epidermal growth factor receptor	11.0	Publications
42	CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	11.0	Publications
43	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
44	RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	11.0
45	PTK2	PTK2 protein tyrosine kinase 2	11.0
46	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	11.0	Publications
47	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications
48	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0	Publications
49	FHIT	fragile histidine triad	11.0	Publications
50	LGALS7B	lectin, galactoside-binding, soluble, 7B	11.0	Publications

Pathways related to laryngeal squamous cell carcinoma according to GeneDecks:

(show top 50)    (show all 298)

id	Pathway	Score	Top Affiliating Genes
1	Signal transduction_PTEN pathway41	10.9	PCNA, CASP9
2	Cell Cycle / Checkpoint Control3	10.7	RECQL4, PCNA, RB1, CHFR, AURKA, AURKB
3	Cyclins and Cell Cycle Regulation36	10.4	RB1, RAF1, CDKN1A, CDK2, CDKN2B, CDKN2A
4	Cell adhesion PLAU signaling10	10.4	RAF1, ITGA8, MET, PTK2, PLAU, PLAUR
5	Glioblastoma Multiforme36	10.4	RB1, RAF1, CDKN1A, CDK2, CDK4, MGMT
6	Cell cycle20	10.4	SFN, PCNA, RB1, MYC, CDKN1A, CDK2
7	Signal transduction_AKT signaling41	10.3	PCNA, MYC, BAD, BAX, CDKN1A, MET
8	p53 signaling pathway20	10.3	SFN, BAX, CDKN1A, CDK2, CDKN2A, CD82
9	Small cell lung cancer20	10.3	RB1, MYC, BCL2, CDK2, CDKN2B, CDK4
10	Colorectal cancer20	10.2	BAD, MSH2, CASP9, TGFB1, TGFBR2
11	Glioma Invasiveness36	10.1	VEGFC, CD44, ITGA8, ITGAV, ITGB8, AREG
12	JNK Pathway36	10.0	RAF1, BCL2, BAX, FLT4, AREG, FGF2
13	Non-small cell lung cancer20	10.0	RB1, RAF1, BAD, CDKN2A, CDK4, FHIT
14	Akt Signaling36	10.0	VEGFC, RAF1, ITGA8, ITGB8, FLT4, MET
15	Signal transduction PTEN pathway10	10.0	PCNA, RAF1, BAD, CDKN1A, MAPK3, MAPK1
16	Melanoma20	9.9	RB1, RAF1, BAD, CDKN1A, CDKN2A, CDK4
17	Apoptosis and Autophagy3	9.9	PIM1, MYC, BMF, BIRC5, BIRC7, BCL10
18	Apoptosis Signaling Pathways37	9.8	SFN, BIRC5, BIRC7, BCL2, BAD, BAX
19	Calpain Protease Regulates Cellular Mechanics36	9.6	RB1, CDK2, CDK4, ITGA8, ITGAV, ITGB8
20	Cell adhesion_PLAU signaling41	9.6	RAF1, ITGA8, MET, ILK, MAPK3, MAPK1
21	Breast Cancer Regulation by Stathmin136	9.5	RAF1, FGF2, MAP2K4, CCNB1, CCNG1, ERBB3
22	PTEN Pathway36	9.4	VEGFC, ITGA8, ITGB8, FN1, FLT4, AREG
23	Endometrial cancer20	9.4	MYC, RAF1, CDH1, MLH1, ILK, MAPK3
24	Prostate cancer20	9.4	RB1, RAF1, BCL2, BAD, CDKN1A, CDK2
25	Cell adhesion ECM remodeling10	9.2	CD44, MMP1, MMP13, MMP14, MMP2, MMP9
26	Cell adhesion_ECM remodeling41	9.1	CD44, MMP1, MMP13, MMP14, MMP2, MMP9
27	Development_EGFR signaling pathway41	9.1	MYC, RAF1, MMP2, MMP9, AREG, ILK
28	UPA-UPAR Pathway36	9.1	ITGA8, ITGAV, ITGB8, MMP1, MMP13, MMP2
29	Focal adhesion20	9.0	VEGFC, RAF1, BCL2, BAD, ITGA8, ITGAV
30	p53 Mediated Apoptosis36	8.8	VEGFC, BCL2, BAX, FLT4, AREG, FGF2
31	Mitochondrial Apoptosis36	8.8	VEGFC, BCL2, BAD, BAX, CDKN2A, FLT4
32	DHA Signaling36	8.8	VEGFC, BCL2, BAD, BAX, FLT4, AREG
33	Bladder cancer20	8.6	RB1, VEGFA, VEGFC, MYC, RAF1, CDKN1A
34	TGF-Beta Pathway36	8.6	VEGFC, BCL2, BAX, CDH1, FLT4, AREG
35	Ras Pathway36	8.5	VEGFC, RAF1, ITGA8, ITGAV, ITGB8, FLT4
36	Cellular Apoptosis Pathway36	8.5	VEGFC, BCL2, BAD, BAX, CFLAR, CDKN2A
37	Rac1 Pathway36	8.4	RAF1, CFL1, ITGA8, ITGAV, ITGB8, FLT4
38	PAK Pathway36	8.1	VEGFC, BCL2, BAX, CFL1, FLT4, AREG
39	ILK Signaling36	8.0	VEGFC, BAD, CFL1, CDH1, ITGAV, ITGB8
40	GPCR Pathway36	7.8	VEGFC, RAF1, BCL10, FLT4, AREG, FGF2
41	Pancreatic Adenocarcinoma36	7.7	RB1, VEGFC, RAF1, BIRC5, BCL2, CDKN1A
42	Tec Kinases Signaling36	7.5	VEGFC, BCL2, BAX, ITGA8, ITGAV, ITGB8
43	Colorectal Cancer Metastasis36	7.4	MYC, BIRC5, BAX, MSH2, CDKN1A, CDH1
44	JAK-STAT Pathway36	7.2	VEGFC, MYC, RAF1, BCL2, BAX, FLT4
45	MAPK Signaling36	7.2	VEGFC, MYC, RAF1, BCL2, ITGA8, ITGAV
46	Molecular Mechanisms of Cancer36	7.0	RB1, VEGFC, MYC, RAF1, BCL2, BAD
47	p38 Signaling36	7.0	VEGFC, BCL2, ZAP70, BAX, FLT4, AREG
48	Rho Family GTPases36	6.8	VEGFC, RAF1, BCL2, BAX, CFL1, CDH1
49	ERK Signaling36	6.8	VEGFC, MYC, RAF1, ZAP70, ITGA8, ITGAV
50	Pathways in cancer20	6.7	RB1, VEGFA, VEGFC, MYC, BIRC5, BCL2

Compounds related to laryngeal squamous cell carcinoma according to GeneDecks:

(show top 50)    (show all 506)

id	Compound	Score	Top Affiliating Genes
1	phosphatidylserine32 9 9	12.4	BCL2, LGALS1, ZAP70, BAD, CDK2, APAF1
2	vincristine32 34 9 9	13.4	MGMT, FGF2, MAP2K4, MAPK3, RPSA
3	progestin32	10.3	VEGFA, CDK4, CDH1, CCND1, IGF2, CTSD
4	glyceraldehyde 3-phosphate32	10.2	VEGFC, BLZF1, BIRC5, CLU, LGALS1, LGALS3
5	taxane32	10.1	VEGFA, BIRC5, BCL2, MTHFR, AURKA, CDKN1A
6	vitamin a32 9 18 9	13.0	RB1, RBP1, NAT2, MYC, RAF1, BLZF1
7	lovastatin32 42 9 9	13.0	RB1, RAF1, CDKN1A, CDK2, CDKN2A, CDK4
8	flavopiridol32 9 9	11.9	RB1, VEGFA, BIRC5, BCL2, BAX, CFLAR
9	nocodazole32 42 9 9	12.9	RAF1, BIRC5, BAG1, CDKN1A, CDKN3, CDH1
10	thymidylate32	9.7	PCNA, RB1, VEGFA, BIRC5, BCL2, BAX
11	4-hydroxytamoxifen32	9.7	MYC, CLU, AREG, FASLG, MAPK1, HMGB1
12	azathioprine32 34 9 9	12.7	PCNA, MTHFR, CDKN2B, CDKN2A, CD44, CDH1
13	noxa32	9.6	BIRC5, BCL2, BAD, BAX, CFLAR, CDKN1A
14	erlotinib32 34 9 9	12.5	VEGFA, BIRC5, CDKN3, CDH1, AREG, MAPK1
15	glycogen32 18	10.4	MYC, LGALS3, BAD, CDK2, CDKN3, CDK4
16	formaldehyde32 18	10.4	PCNA, RB1, BLZF1, LGALS3, ZAP70, CDKN3
17	pge232	9.3	RAF1, CDH1, MMP1, MMP13, FN1, FGF2
18	fludarabine32 9 9	11.3	BIRC5, BCL2, ZAP70, BAG1, BAX, CDK2
19	arginine32	9.2	BLZF1, LGALS1, CDK2, CDK4, CD44, MLH1
20	aspartate32	9.2	PCNA, RAF1, AURKA, CDKN2A, CDH1, MMP2
21	suberoylanilide hydroxamic acid32	9.2	MYC, RAF1, BIRC5, BCL2, BAX, CFLAR
22	mitomycin c32	9.1	PCNA, RB1, BIRC5, AREG, MGMT, FGF2
23	agarose32	9.1	MYC, BLZF1, CLU, BCL2, LGALS1, BAD
24	bleomycin32 9 9	11.1	CDKN3, CD44, GSTM1, GSTP1, FGF2, IL13
25	phosphoinositide32	8.8	BSG, RAF1, BIRC5, LGALS3, BAD, CDK2
26	etoposide32 42 9 9	11.8	PCNA, RB1, MYC, BIRC5, CLU, BCL2
27	atp32	8.7	PIM1, RB1, MYBPC1, BLZF1, BIRC5, CLU
28	15-deoxy-delta-12,14-prostaglandin j232	8.6	VEGFA, MYC, BIRC5, CDKN1A, CDK2, CD36
29	ribonucleic acid32	8.4	VEGFC, MYC, BLZF1, CLU, MMP1, MMP13
30	tacrolimus32 34 9 9	11.3	PCNA, MYC, RAF1, BAD, CD36, CDKN3
31	tgf beta132	8.3	BLZF1, CDKN1A, CDK2, CD36, CDKN2B, CDK4
32	docetaxel32 34 9 9	11.1	VEGFA, MYC, RAF1, BIRC5, CLU, BCL2
33	resveratrol32 9 18 9	11.0	PCNA, RB1, BSG, VEGFA, RAF1, BIRC5
34	cysteine32	7.9	PCNA, NAT2, RAF1, BLZF1, CLU, PARK7
35	thapsigargin32 42	8.9	PCNA, RAF1, BLZF1, BCL2, CD36, CDKN3
36	vitamin d32	7.8	CLU, LGALS3, BAG1, MTHFR, CDKN1A, CDK2
37	ag 147832	7.8	RAF1, CDK2, MMP14, MMP2, MMP9, AREG
38	daunorubicin32 9 9	9.8	MYC, RAF1, BIRC5, BCL2, BAX, CD36
39	doxorubicin32 34 9 9	10.8	RAF1, CLU, BAD, CFLAR, MSH2, CDK2
40	gemcitabine32 34 9 9	10.7	PCNA, VEGFA, MYC, BIRC5, BCL2, BAX
41	gefitinib32 34 9 9	10.6	VEGFA, BIRC5, BAD, CDKN1A, CDK2, CDKN3
42	indomethacin32 9 9	9.6	PCNA, MYC, RAF1, BIRC5, LGALS1, CDK2
43	alanine32	7.5	PIM1, PCNA, MYC, RAF1, BLZF1, BIRC5
44	testosterone32 9 18 9	10.4	PCNA, RB1, VEGFC, RAF1, BLZF1, BIRC5
45	cyclosporin a32 42	8.3	BSG, MYC, RAF1, BLZF1, BAD, MTHFR
46	glutamate32	7.2	PCNA, BSG, BLZF1, CLU, LGALS3, MTHFR
47	5fluorouracil32	7.0	PCNA, RB1, VEGFA, BIRC5, BIRC7, BCL2
48	paclitaxel32 34 9 9	9.0	PCNA, RB1, VEGFA, MYC, RAF1, BIRC5
49	cisplatin32 34 9 9	8.1	PCNA, RB1, VEGFA, MYC, RAF1, BLZF1
50	dexamethasone32 42 34 9 9	8.1	PCNA, RB1, NAT2, VEGFA, VEGFC, MYC

Cellular components related to laryngeal squamous cell carcinoma according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	cyclin-dependent protein kinase holoenzyme complex	GO:000307	10.7	CCND1, CCND3, CDK4, CDK2, CDKN1A
2	extracellular matrix	GO:031012	10.2	ACAN, COL1A1, CTSD, FN1, MMP14, LGALS3
3	platelet alpha granule lumen	GO:031093	9.5	HGF, TGFB1, TIMP1, EGF, FN1, CLU
4	nucleoplasm	GO:005654	9.5	HMGB1, ERBB4, TP53, TP63, TERT, SP140
5	proteinaceous extracellular matrix	GO:005578	9.4	TFPI2, TGFB1, ACAN, FN1, MMP9, MMP20
6	caveola	GO:005901	9.4	TGFBR2, PTGS2, ERBB4, CAV1, MAPK1, MAPK3
7	perinuclear region of cytoplasm	GO:048471	9.2	CAV1, ERBB2, PTK2B, SPP1, CTNNB1, NOS2
8	cell surface	GO:009986	8.9	CXCR4, TGFB1, PLAUR, PLAU, CYP3A4, HMGB1
9	nucleolus	GO:005730	8.5	PTK2B, TERT, TP63, TP53, ERBB4, HMGB1
10	extracellular region	GO:005576	7.3	PLAU, CTSD, SPP1, ERBB4, HMGB1, HPSE
11	cytosol	GO:005829	7.3	RAF1, BMF, MYBPC1, NAT2, BIRC5, NME1
12	extracellular space	GO:005615	7.1	SPP1, ERBB3, HMGB1, IGF2, ANGPT1, ANXA1
13	cytoplasm	GO:005737	7.0	NFKB1, COPS5, RPSA, NOS2, CTNNB1, SP140
14	nucleus	GO:005634	6.6	CASP3, APAF1, AQP1, FGF2, GSTP1, FHIT

Biological processes related to laryngeal squamous cell carcinoma according to GeneDecks:

(show top 50)    (show all 74)

id	Name	GO ID	Score	Top Affiliating Genes
1	mitotic cell cycle	GO:000278	11.4	MCM2, CCNB1, CCNA2, CCND1, CCNA1, SKP2
2	G1/S transition of mitotic cell cycle	GO:000082	11.2	CCNB1, CCND1, CCNA1, SKP2, EIF4E, PSME2
3	regulation of cyclin-dependent protein kinase activity	GO:000079	11.0	PTEN, CCNG1, CCNA1, CCNA2, CCNB1, CDKN3
4	G1 phase of mitotic cell cycle	GO:000080	10.9	SKP2, CCND1, CDK4, CDKN2A, CDKN2B, CDKN1A
5	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO:043154	10.7	HGF, CSNK2A1, AQP1, CD44, BIRC5, RAF1
6	release of cytochrome c from mitochondria	GO:001836	10.6	TP73, TP53, CASP3, BAX, BCL2, CLU
7	response to estrogen stimulus	GO:043627	10.6	KRT19, CTNNA1, CAV1, CCND1, ANGPT1, FAS
8	Ras protein signal transduction	GO:007265	10.6	TP53, CCNA2, MAPK1, MAPK3, FGF2, CDKN2A
9	neuron apoptotic process	GO:051402	10.5	TP63, TP53, ERBB3, CASP3, FAS, BAX
10	regulation of apoptotic process	GO:042981	10.4	NME1, CSTB, PSME2, TP53, CASP9, CASP3
11	activation of pro-apoptotic gene products	GO:008633	10.4	CASP8, IFI27, FAS, FASLG, BAX, BAD
12	induction of apoptosis by intracellular signals	GO:008629	10.3	APAF1, CASP3, CASP8, CASP9, TP53, CDKN1A
13	apoptotic DNA fragmentation	GO:006309	10.3	HMGB1, CASP3, CDKN2A, BAX, BIRC7, MYC
14	cell proliferation	GO:008283	10.3	ERBB4, ERBB2, TP53, PTEN, PDPN, SKP2
15	positive regulation of peptidyl-serine phosphorylation	GO:033138	10.3	TGFB1, CAV1, ANGPT1, MET, CD44, BCL2
16	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	10.2	CASP8, IFI27, FAS, FASLG, APAF1, CDKN2A
17	response to DNA damage stimulus	GO:006974	10.1	CASP3, CASP9, TP53, TP73, CCND1, MAPK3
18	protein autophosphorylation	GO:046777	10.1	AURKA, AURKB, FLT4, MET, ERBB4, ERBB2
19	extracellular matrix disassembly	GO:022617	10.1	TIMP1, ENG, MMP9, MMP2, MMP14, MMP13
20	regulation of cell proliferation	GO:042127	10.1	TGFBR2, NOS2, PTK2, ERBB3, ANXA1, ENG
21	response to organic cyclic compound	GO:014070	10.1	MSH2, CDKN1A, MET, ENO2, ANGPT2, ANXA1
22	anti-apoptosis	GO:006916	10.0	ANGPT1, HSP90B1, TNFRSF10D, TERT, NFKB1, HGF
23	cell cycle arrest	GO:007050	10.0	TGFB1, TP73, TP53, ILK, CDKN3, CDKN2A
24	angiogenesis	GO:001525	10.0	PTEN, PTK2, EGF, HIF1A, TYMP, CASP8
25	organ regeneration	GO:031100	10.0	HGF, TGFB1, CCND1, ANGPT1, ANGPT2, MKI67
26	negative regulation of apoptotic process	GO:043066	9.9	PIM1, VEGFA, MYC, CASP3, ERBB4, TP53
27	extracellular matrix organization	GO:030198	9.9	TIMP1, COL4A6, COL1A1, PTK2, MMP9, MMP2
28	positive regulation of cell migration	GO:030335	9.9	TGFB1, EGFR, PDPN, COL1A1, PTK2, PTK2B
29	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.9	HGF, PTK2B, TP53, IGF2, ANGPT1, CD44
30	positive regulation of protein phosphorylation	GO:001934	9.8	ERBB4, ERBB2, PTK2, TGFB1, IGF2, CCND1
31	positive regulation of epithelial cell proliferation	GO:050679	9.7	NME1, TGFB1, EGFR, ERBB2, ERBB4, BAD
32	cellular response to mechanical stimulus	GO:071260	9.7	NFKB1, COL1A1, CASP8, MAPK3, MAP2K4, FAS
33	induction of apoptosis by extracellular signals	GO:008624	9.6	CAV1, CASP8, CASP3, BAD, BAX, CFLAR
34	virus-host interaction	GO:019048	9.6	TP53, KRT19, EIF4E, TGFB1, STAT3, CXCR4
35	positive regulation of blood vessel endothelial cell migration	GO:043536	9.5	VEGFA, VEGFC, FGF2, ANGPT1, TGFB1
36	negative regulation of cell proliferation	GO:008285	9.5	PTEN, PTGS2, PTK2B, CTNNB1, TGFB1, CSNK2B
37	induction of apoptosis	GO:006917	9.4	CASP3, TP63, PTEN, TGFB1, MAPK1, FAS
38	platelet degranulation	GO:002576	9.2	EGF, TIMP1, TGFB1, HGF, FN1, CD36
39	epidermal growth factor receptor signaling pathway	GO:007173	9.2	TGFB1, EGFR, EGF, PTEN, ERBB2, CASP9
40	positive regulation of apoptotic process	GO:043065	9.0	PTGS2, TP53, HMGB1, ANXA1, FAS, FASLG
41	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.0	TP53, TP63, TP73, CTNNB1, COPS5, NFKB1
42	response to estradiol stimulus	GO:032355	8.9	STAT3, TGFB1, CTNNB1, PTGS2, CASP8, ANXA1
43	response to hypoxia	GO:001666	8.9	HSP90B1, CAV1, NOS2, HIF1A, TGFB1, CXCR4
44	platelet activation	GO:030168	8.8	PTK2, COL1A1, EGF, TIMP1, TGFB1, HGF
45	positive regulation of transcription, DNA-dependent	GO:045893	8.8	TP63, TP73, CTCF, CTNNB1, COL1A1, NFKB1
46	apoptotic process	GO:006915	8.4	PIM1, BAX, CFLAR, MSH2, CDH1, FGF2
47	blood coagulation	GO:007596	8.4	PLAUR, PLAU, PTK2, TP53, CAV1, NOS2
48	positive regulation of cell proliferation	GO:008284	8.3	ERBB4, PTEN, PTK2B, PTK2, EGF, EGFR
49	signal transduction	GO:007165	8.2	PLAU, PTK2B, TNFRSF10D, TNFRSF10C, ERBB2, ERBB4
50	response to drug	GO:042493	8.1	MSH2, CAV1, ERBB3, ERBB4, PTGS2, CTNNB1

Molecular functions related to laryngeal squamous cell carcinoma according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase binding	GO:019901	10.7	CCND1, CCNA1, TP53, TP73, PTEN, PTK2
2	identical protein binding	GO:042802	10.5	TP53, TP63, TP73, COL1A1, SKP2, EGFR
3	cyclin-dependent protein kinase inhibitor activity	GO:004861	10.3	CDKN1A, CDKN2B, CDKN2A, CASP3
4	protein phosphatase binding	GO:019903	10.1	EGFR, CTNNB1, ERBB2, HSP90B1, FLT4, CDH1
5	transcription factor binding	GO:008134	10.1	CSNK2B, STAT3, HIF1A, CTNNB1, TP73, TP53
6	ubiquitin protein ligase binding	GO:031625	10.0	CXCR4, HIF1A, TP53, AURKA, BCL2, BCL10
7	protein tyrosine kinase activity	GO:004713	9.6	EGFR, PTK2B, ERBB2, ERBB4, ERBB3, MAP2K4
8	protein heterodimerization activity	GO:046982	9.5	ERBB3, ERBB2, TP53, EGFR, HIF1A, TGFB1
9	ATP binding	GO:005524	8.8	ERBB4, ERBB3, HSPA4, HSP90B1, MAPK1, MAPK3
10	protein homodimerization activity	GO:042803	8.7	ANXA1, ERBB3, ERBB4, TERT, PTGS2, NOS2
11	enzyme binding	GO:019899	8.7	CYP3A4, CYP2E1, CTNNB1, PLAUR, EGFR, HIF1A
12	growth factor activity	GO:008083	8.2	HGF, CSF3, TGFB1, TYMP, EGF, IGF2
13	protein binding	GO:005515	3.7	ENG, CAV1, CASP9, HPSE, HMGB1, ERBB3