MCID: LRY018
MIFTS: 56

Laryngeal Squamous Cell Carcinoma malady

Cancer diseases, Skin diseases, Oral diseases categories
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Summaries for Laryngeal Squamous Cell Carcinoma

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33MalaCards
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MalaCards: Laryngeal Squamous Cell Carcinoma, also known as epidermoid carcinoma of the larynx, is related to papilloma and lung adenocarcinoma. An important gene associated with Laryngeal Squamous Cell Carcinoma is GSTM3 (glutathione S-transferase mu 3 (brain)), and among its related pathways are IL-2 Gene Expression in Activated and Quiescent T-Cells and Small cell lung cancer. The compounds drugs for treatment of tuberculosis and p00001 have been mentioned in the context of this disorder. Affiliated tissues include lymph node, endothelial and thyroid, and related mouse phenotypes are digestive/alimentary and embryogenesis.

Aliases & Classifications for Laryngeal Squamous Cell Carcinoma

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases, Oral diseases


Aliases & Descriptions:

laryngeal squamous cell carcinoma 8 10 45 62
epidermoid carcinoma of the larynx 8
squamous cell carcinoma of larynx 8


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Disease Ontology8 DOID:2876
SNOMED-CT58 405822008
NCIt40 C4044

Related Diseases for Laryngeal Squamous Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Laryngeal Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma31.0CDKN2B, CDKN2A
2lung adenocarcinoma30.2CDKN2A, GSTT1, GSTM1, BIRC5, CCND1, TERT
3retinoblastoma30.1CDKN2B, CDKN2A, NME1, BIRC5, CCND1, CCNA2
4adenocarcinoma29.8CTSD, CDKN2A, EIF4E, NME1, GSTT1, GSTM1
5laryngitis11.6
6endotheliitis10.7
7cervicitis10.6
8thyroiditis10.6
9hypoxia10.6
10pharyngitis10.4
11nasopharyngitis10.4
12papillary thyroid carcinoma10.4
13sarcocystosis10.2
14conjunctivitis10.2
15epidermolysis bullosa10.2
16histoplasmosis10.2
17hodgkin's lymphoma10.2
18laryngeal carcinoma10.2
19lipoma10.2
20kindler syndrome10.2
21neuronal ceroid-lipofuscinoses10.1CTSD
22gliomatosis cerebri10.1PTEN
23skin melanoma10.1CDKN2B, NME1
24esophageal cancer10.1CDKN2A, CCND1
25ependymoma10.1CDKN2B, MKI67
26burkitt's lymphoma10.1CDKN2B, CCND1
27malignant mesothelioma10.1CDKN2B, CDKN2A, NAT2
28parathyroid carcinoma10.1CCND1, MKI67
29cataract10.1GSTT1, GSTM3, NAT2
30familial colorectal cancer10.1CDKN2A, PTEN
31bladder transitional cell carcinoma10.1CDKN2B, BIRC5, MKI67
32familial adenomatous polyposis10.1BIRC5, CCND1, NAT2
33oligodendroglioma10.1CDKN2B, CDKN2A, PTEN
34cervical adenocarcinoma10.1CDKN2A, NME1
35anaplastic oligodendroglioma10.1CDKN2B, CDKN2A, PTEN
36adenosquamous carcinoma10.1CTSD, NME1
37keratoacanthoma10.0NME1, MKI67
38rectal neoplasm10.0BIRC5, NAT2
39breast cancer10.0CTSD, CCND1, AURKA
40hematologic cancer10.0CDKN2B, BIRC5, CCNA2
41phyllode tumor10.0CCNA2, MKI67
42follicular adenoma10.0CDKN2B, NME1, PTEN
43gastritis10.0GSTT1, TERT
44follicular thyroid carcinoma10.0NME1, PTEN
45brain cancer10.0GSTT1, GSTM1
46asbestosis10.0GSTT1, GSTM1
47b-cell chronic lymphocytic leukemia10.0BIRC5, CCND1, CCNA2
48breast fibroadenoma10.0CTSD, NME1, MKI67
49cholangiocarcinoma10.0EIF4E, NAT2, TERT
50cervical squamous cell carcinoma10.0CDKN2A, MKI67

Graphical network of the top 20 diseases related to Laryngeal Squamous Cell Carcinoma:



Diseases related to laryngeal squamous cell carcinoma

Symptoms for Laryngeal Squamous Cell Carcinoma

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Drugs & Therapeutics for Laryngeal Squamous Cell Carcinoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Laryngeal Squamous Cell Carcinoma

Search NIH Clinical Center for Laryngeal Squamous Cell Carcinoma

Genetic Tests for Laryngeal Squamous Cell Carcinoma

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Anatomical Context for Laryngeal Squamous Cell Carcinoma

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33MalaCards
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MalaCards organs/tissues related to Laryngeal Squamous Cell Carcinoma:

33
Lymph node, Endothelial, Thyroid, Skin, T cells, Lung, Pituitary

Animal Models for Laryngeal Squamous Cell Carcinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Laryngeal Squamous Cell Carcinoma:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4CTSD, CDKN2A, CCND1, PTEN, TERT
2MP:00053808.2AURKA, PTEN, CCNA2, BIRC5, NME1, CDKN2A
3MP:00053898.1TERT, PTEN, NAT2, CCND1, CDKN2A, CDKN2B
4MP:00053797.9TERT, PTEN, CCND1, NME1, CDKN2A, CDKN2B
5MP:00020067.8CDKN2B, TERT, AURKA, PTEN, CCND1, NME1
6MP:00053877.4TERT, PTEN, CCNA2, CCND1, BIRC5, CDKN2A
7MP:00053977.2TERT, PTEN, CCNA2, CCND1, BIRC5, NME1
8MP:00107686.9TERT, AURKA, PTEN, CCNA2, CCND1, BIRC5
9MP:00036316.8TERT, PTEN, CCND1, GSTM1, NME1, CDKN2A
10MP:00053766.3CCND1, NAT2, PTEN, TERT, BIRC5, GSTM1
11MP:00053846.3TERT, AURKA, PTEN, CCNA2, CCND1, BIRC5

Publications for Laryngeal Squamous Cell Carcinoma

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52PubMed
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Articles related to Laryngeal Squamous Cell Carcinoma:

(show top 50)    (show all 561)
idTitleAuthorsYear
1
Identification of cancer stem-like side population cells in purified primary cultured human laryngeal squamous cell carcinoma epithelia. (23776540)
2013
2
Comprehensive expression profiling of microRNAs in laryngeal squamous cell carcinoma. (22605671)
2013
3
Heterogeneity of 11q13 region rearrangements in laryngeal squamous cell carcinoma analyzed by microarray platforms and fluorescence in situ hybridization. (23652995)
2013
4
Significance of MDM2-309 Polymorphisms and Induced Corresponding Plasma MDM2 Levels in Susceptibility to Laryngeal Squamous Cell Carcinoma. (24325471)
2013
5
High CCR6/CCR7 expression and Foxp3+ Treg cell number are positively related to the progression of laryngeal squamous cell carcinoma. (23835793)
2013
6
Expression and clinicopathological significance of foxM1 gene in laryngeal squamous cell carcinoma]. (23285957)
2012
7
Cigarette smoking and alcohol ingestion as risk factors for laryngeal squamous cell carcinoma at kenyatta national hospital, kenya. (24179405)
2012
8
Expression of VEGF-C/VEGFR-3 in human laryngeal squamous cell carcinomas and its significance for lymphatic metastasis. (22502683)
2012
9
The cadherin-catenin complex in laryngeal squamous cell carcinoma. (22197995)
2012
10
The expression and relationship of CXCR4 and microvessel density in laryngeal squamous cell carcinoma]. (21553525)
2011
11
The involvement of CHD5 hypermethylation in laryngeal squamous cell carcinoma. (21636313)
2011
12
Aurora B kinase expression in laryngeal squamous cell carcinoma and its prognostic implications. (21299608)
2011
13
Podoplanin expression in the development and progression of laryngeal squamous cell carcinomas. (20196862)
2010
14
Study of mRNA expression level and hypermethylation of CHFR promoter in the laryngeal squamous cell carcinoma tissue]. (20942233)
2010
15
Silencing STAT3 with short hairpin RNA enhances radiosensitivity of human laryngeal squamous cell carcinoma xenografts in vivo. (22993624)
2010
16
Assessment of disease-free survival in patients with laryngeal squamous cell carcinoma treated with radiotherapy associated or not with chemotherapy. (20549084)
2010
17
The expression of hepatocyte growth factor and heparanase in laryngeal squamous cell carcinoma and its clinical significance]. (19452723)
2009
18
Expression and pathobiological significance of Col I, Col IV and Fn in laryngeal squamous cell carcinomas]. (20359090)
2009
19
Overexpression of mitogen-activated protein kinase kinase 4 and nuclear factor-kappaB in laryngeal squamous cell carcinoma: a potential indicator for poor prognosis. (19513509)
2009
20
CD105 expression as a measure of microvessel density in supraglottic laryngeal squamous cell carcinoma. (19340447)
2009
21
Loss of imprinting of IGF2 and H19, loss of heterozygosity of IGF2R and CTCF, and Helicobacter pylori infection in laryngeal squamous cell carcinoma. (18604514)
2008
22
Expression of Livin in laryngeal squamous cell carcinoma and relationship with bFGF]. (18476630)
2008
23
The mutation and expression of MUS81 gene in laryngeal squamous cell carcinoma]. (18841572)
2008
24
Association between genetic polymorphisms in methylenetetrahydrofolate reductase and risk of laryngeal squamous cell carcinoma]. (18826096)
2008
25
Expression of cyclin G1 in laryngeal squamous cell carcinoma and its clinicopathologic significance]. (18788592)
2008
26
The relationship between the activation of ERK and the up-regulation of uPA in laryngeal squamous cell carcinoma]. (17634019)
2007
27
Combined p14ARF and antisense EGFR potentiate the efficacy of adenovirus-mediated gene therapy in laryngeal squamous cell carcinoma (LSCC). (17328665)
2007
28
The expressions and significance of CK2 in normal laryngeal mucosa, laryngeal precancerosis and laryngeal squamous cell carcinoma]. (18062282)
2007
29
Clinical significance and expression of FLIP and PTEN protein in laryngeal squamous cell carcinoma]. (17441421)
2007
30
Fas expression is associated with a better prognosis in laryngeal squamous cell carcinoma. (18225575)
2007
31
The expression of tumor necrosis factor related apoptosis induce ligand in human laryngeal squamous cell carcinoma]. (17357513)
2006
32
Expression of telomerase reverse transcriptase and its relationship with expression of c-myc in laryngeal squamous cell carcinomas]. (17219990)
2006
33
Multivariate survival analysis in patient with laryngeal squamous cell carcinomas]. (17017186)
2006
34
Effect of dietary antioxidants and risk of oral, pharyngeal and laryngeal squamous cell carcinoma according to smoking and drinking habits. (16800818)
2006
35
Predictive factors of neck metastases in laryngeal squamous cell carcinoma. Towards an integrated clinico-molecular classification. (17633151)
2006
36
Overexpression of the cytokine osteopontin identifies aggressive laryngeal squamous cell carcinomas and enhances carcinoma cell proliferation and invasiveness. (16299231)
2005
37
Prognostic significance of Jab1 expression in laryngeal squamous cell carcinomas. (15671554)
2005
38
Overexpression of MMP-2 in laryngeal squamous cell carcinoma: a potential indicator for poor prognosis. (15746850)
2005
39
Laryngeal squamous cell carcinoma with ectopic production of granulocyte colony-stimulating factor and parathyroid hormone-related protein. (15990969)
2005
40
Combination of adenovirus p16(INK4A) gene therapy and ionizing radiation for laryngeal squamous cell carcinoma]. (15071918)
2004
41
Expression of VEGF-C and VEGFR-3 in human laryngeal squamous cell carcinomas and cervical metastatic lymph node tissues]. (15715411)
2004
42
Expression and significance of PTEN and caspase-3 in laryngeal squamous cell carcinoma]. (15831044)
2004
43
Gene expression of matrix metalloproteinase 14 in laryngeal squamous cell carcinoma]. (15563089)
2004
44
Correlation of FHIT expression to cell proliferation and metastasis of laryngeal squamous cell carcinoma]. (15522186)
2004
45
p63 in laryngeal squamous cell carcinoma: evidence for a role of TA-p63 down-regulation in tumorigenesis and lack of prognostic implications of p63 immunoreactivity. (12379767)
2002
46
Quantitative measurement of telomerase catalytic subunit (hTERT) mRNA in laryngeal squamous cell carcinomas. (11911285)
2001
47
The study of p16 gene mutation and methylation in laryngeal squamous cell carcinoma]. (12768709)
2000
48
Immunohistochemical study of Cath-D and CD44 in laryngeal squamous cell carcinomas]. (11189153)
1998
49
Microvessel count is predictive of patients' survival in laryngeal squamous-cell carcinoma. (8900379)
1996
50
Prognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma. (8883413)
1996

Variations for Laryngeal Squamous Cell Carcinoma

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Expression for genes affiliated with Laryngeal Squamous Cell Carcinoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Laryngeal Squamous Cell Carcinoma

Search GEO for disease gene expression data for Laryngeal Squamous Cell Carcinoma.

Pathways for genes affiliated with Laryngeal Squamous Cell Carcinoma

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Sources:
50PathCards, 53QIAGEN, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters, 51PharmGKB, 55Reactome, 54R&D Systems, 5Cell Signaling Technology
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Pathways related to Laryngeal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6CCND1, CCNA2
29.4CDKN2B, CCND1, PTEN
3
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
9.4CDKN2B, CCND1, PTEN
4
Show member pathways
Signal transduction PTEN pathway60
9.4PTEN, CCND1, BIRC5
59.4AURKA, PTEN, CCND1
69.3GSTT1, GSTM1
79.3GSTT1, GSTM1
8
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
9.3CDKN2A, CCND1, PTEN
9
Show member pathways
DNA damage response38
9.3PTEN, CCND1, CDKN2A
109.3CDKN2A, CCND1, PTEN
11
Show member pathways
glutathione-mediated detoxification I38
glutathione redox reactions I38
glutathione redox reactions II38
4-hydroxy-2-nonenal detoxification38
Glutathione metabolism60
Glutathione metabolism38
9.1GSTT1, GSTM1, GSTM3
12
Show member pathways
Signaling Pathways in Glioblastoma38
9.1CDKN2B, CDKN2A, CCND1, PTEN
13
Show member pathways
Cell cycle38
9.0CCNA2, CCND1, CDKN2A, CDKN2B
14
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.0CCNA2, CCND1, CDKN2A, CDKN2B
15
Show member pathways
9.0CCNA2, CCND1, CDKN2A, CDKN2B
169.0CCNA2, CCND1, CDKN2A, CDKN2B
17
Show member pathways
9.0CDKN2B, CDKN2A, CCND1, CCNA2
188.9EIF4E, NME1, BIRC5, TERT
198.9TERT, CCND1, CDKN2A, CDKN2B
20
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
8.9PTEN, CCNA2, CCND1, BIRC5
21
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.9BIRC5, CCND1, CCNA2, PTEN
22
Show member pathways
8.8GSTT1, GSTM1, GSTM3, NAT2
23
Show member pathways
8.8NAT2, GSTM3, GSTM1, GSTT1
248.8PTEN, CCND1, BIRC5, CDKN2A, CDKN2B
25
Show member pathways
8.8CCNA2, CCND1, BIRC5, CDKN2A, CDKN2B
268.5PTEN, CCNA2, CCND1, NME1, CDKN2B
27
Show member pathways
8.5AURKA, MKI67, CCNA2, CCND1, CDKN2A
28
Show member pathways
8.0PTEN, NAT2, GSTM3, GSTM1, GSTT1, NME1
29
Show member pathways
7.9CDKN2B, CDKN2A, BIRC5, CCND1, CCNA2, AURKA

Compounds for genes affiliated with Laryngeal Squamous Cell Carcinoma

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Sources:
51PharmGKB, 45Novoseek, 11DrugBank, 24HMDB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB
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Compounds related to Laryngeal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 210)
idCompoundScoreTop Affiliating Genes
1drugs for treatment of tuberculosis519.4GSTT1, NAT2, GSTM1
2p00001459.2CCND1, CDKN2A, BIRC5, MKI67
3crcs459.0CDKN2A, NME1, BIRC5, CCND1, PTEN
4isoniazid45 51 1111.0NAT2, GSTM1, CDKN2A, GSTT1
5aflatoxin b145 2410.0NAT2, GSTM1, GSTT1, CDKN2A
6gsts458.8NAT2, GSTT1, GSTM1, GSTM3
7adriamycin458.7TERT, CTSD, CDKN2A, BIRC5, CCND1
8chi 2458.7NME1, MKI67, GSTT1, GSTM1
9acetone458.7MKI67, CCND1, GSTM1, GSTT1
10mg 13245 619.6CCNA2, CDKN2A, EIF4E, BIRC5, PTEN, CCND1
11p003458.5CTSD, CDKN2B, GSTT1, GSTM1, MKI67
12agar458.5CCND1, PTEN, EIF4E, CDKN2A, CTSD, NME1
13depsipeptide458.3TERT, CCNA2, CDKN2A, CCND1
14butyrate458.3CDKN2A, CCNA2, CCND1, TERT, CTSD, BIRC5
15tamoxifen45 51 29 1111.3MKI67, PTEN, CCNA2, BIRC5, CCND1, CTSD
16tgf beta1458.3MKI67, PTEN, CDKN2B, CCND1, CCNA2
17p002458.2GSTM1, CTSD, NME1, BIRC5, MKI67, GSTT1
18folate458.2MKI67, NAT2, GSTM1, CCND1, GSTT1, CDKN2A
19pd 98,059458.1PTEN, CDKN2B, CCND1, TERT, BIRC5, EIF4E
20rapamycin458.1CCNA2, PTEN, TERT, EIF4E, BIRC5, CCND1
21estradiol45 24 1110.1BIRC5, CCND1, CCNA2, PTEN, MKI67, CTSD
22ly294002458.1EIF4E, PTEN, TERT, BIRC5, CCND1, CCNA2
23genistein45 29 61 3 24 1112.9TERT, PTEN, CCNA2, BIRC5, CDKN2A, CTSD
24cyclophosphamide45 51 119.9GSTT1, NAT2, MKI67, CTSD, PTEN, GSTM1
25arsenite45 248.9CDKN2B, EIF4E, PTEN, TERT, BIRC5, CCND1
26cycloheximide457.8EIF4E, MKI67, CTSD, PTEN, BIRC5, CCND1
27thymidine45 248.8NME1, BIRC5, CCND1, CTSD, CCNA2, TERT
28etoposide45 51 61 1110.7CCNA2, NME1, TERT, CTSD, EIF4E, GSTT1
29aspartate457.7CTSD, PTEN, CCNA2, GSTM1, NME1, CDKN2A
30vincristine45 51 119.6BIRC5, CDKN2A, CCND1, PTEN, MKI67, GSTM1
31methotrexate51 45 119.6CDKN2B, MKI67, CCND1, CCNA2, CDKN2A, BIRC5
32thymidylate457.4CDKN2A, CCNA2, CCND1, BIRC5, GSTM1, MKI67
33paclitaxel45 51 119.3MKI67, AURKA, BIRC5, CTSD, CDKN2A, TERT
34h2o2457.3CCNA2, GSTM1, CTSD, PTEN, TERT, EIF4E
35progesterone45 29 61 24 1111.2NME1, CCNA2, CTSD, MKI67, CDKN2A, BIRC5
36cysteine457.1NME1, GSTM1, NAT2, CTSD, PTEN, TERT
37steroid457.1CDKN2A, CCNA2, MKI67, EIF4E, NME1, GSTT1
38paraffin457.1CDKN2A, CTSD, NME1, BIRC5, CCNA2, PTEN
39oligonucleotide457.1NAT2, CCND1, PTEN, CCNA2, BIRC5, GSTT1
40threonine457.0PTEN, MKI67, AURKA, CDKN2B, CDKN2A, EIF4E
41nitric oxide45 24 118.9EIF4E, NME1, TERT, PTEN, NAT2, CCNA2
42vegf456.8CTSD, BIRC5, PTEN, CCNA2, CCND1, MKI67
435fluorouracil456.7TERT, MKI67, PTEN, CCNA2, BIRC5, GSTM1
44testosterone45 61 24 119.7CCND1, CCNA2, TERT, PTEN, MKI67, BIRC5
45retinoic acid45 247.6NME1, BIRC5, MKI67, CCNA2, CCND1, PTEN
46doxorubicin45 51 118.4CTSD, CDKN2A, TERT, MKI67, PTEN, CCNA2
47serine456.3BIRC5, CCND1, CCNA2, NME1, EIF4E, CDKN2A
48oxygen45 247.3PTEN, CCNA2, MKI67, GSTM1, GSTT1, EIF4E
49cisplatin45 51 61 118.2CCND1, PTEN, MKI67, TERT, CDKN2A, CTSD
50estrogen454.9CCND1, PTEN, CTSD, CDKN2B, TERT, AURKA

GO Terms for genes affiliated with Laryngeal Squamous Cell Carcinoma

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16Gene Ontology
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Cellular components related to Laryngeal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleolusGO:0057307.9MKI67, PTEN, CCND1, CDKN2A, CDKN2B, TERT
2nucleusGO:0056346.8AURKA, MKI67, PTEN, CCNA2, CCND1, BIRC5
3cytosolGO:0058296.3CDKN2B, AURKA, PTEN, NAT2, CCND1, BIRC5
4cytoplasmGO:0057375.7CCNA2, PTEN, MKI67, TERT, BIRC5, GSTM3

Biological processes related to Laryngeal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of mitotic cell cycleGO:04593110.0EIF4E, BIRC5
2regulation of G2/M transition of mitotic cell cycleGO:0103899.8CCNA2, CDKN2A
3regulation of protein stabilityGO:0316479.7CDKN2A, PTEN, AURKA
4nitrobenzene metabolic processGO:0189169.7GSTM1, GSTM3
5cellular detoxification of nitrogen compoundGO:0704589.7GSTM1, GSTM3
6negative regulation of G1/S transition of mitotic cell cycleGO:20001349.7CDKN2B, PTEN
7response to organic cyclic compoundGO:0140709.7CDKN2B, GSTT1, MKI67
8xenobiotic catabolic processGO:0421789.6GSTM1, GSTM3
9replicative senescenceGO:0903999.6TERT, CDKN2A
10negative regulation of phosphorylationGO:0423269.6CDKN2B, CDKN2A
11G2/M transition of mitotic cell cycleGO:0000869.5AURKA, CCNA2, BIRC5, CDKN2B
12G1/S transition of mitotic cell cycleGO:0000829.5CCND1, EIF4E, CDKN2A
13regulation of cyclin-dependent protein serine/threonine kinase activityGO:0000799.5CDKN2B, CCNA2, PTEN
14glutathione derivative biosynthetic processGO:19016879.4GSTM3, GSTM1, GSTT1
15glutathione metabolic processGO:0067499.4GSTM3, GSTM1, GSTT1
16organ regenerationGO:0311009.3MKI67, CCNA2, CCND1
17xenobiotic metabolic processGO:0068059.1GSTT1, GSTM1, GSTM3, NAT2
18negative regulation of cell proliferationGO:0082859.1CDKN2B, CDKN2A, NME1, PTEN
19mitotic cell cycleGO:0002788.8CDKN2B, CDKN2A, BIRC5, CCND1, CCNA2, AURKA
20small molecule metabolic processGO:0442818.1NME1, GSTT1, GSTM1, GSTM3, NAT2, PTEN

Molecular functions related to Laryngeal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.9CDKN2B, CDKN2A
2glutathione bindingGO:0432959.1GSTM1, GSTM3
3glutathione transferase activityGO:0043649.0GSTM3, GSTM1, GSTT1
4enzyme bindingGO:0198998.4PTEN, CCND1, BIRC5, GSTM3, GSTM1
5protein kinase bindingGO:0199018.0CDKN2B, CDKN2A, NME1, CCND1, CCNA2, PTEN
6protein bindingGO:0055155.9TERT, AURKA, MKI67, PTEN, CCNA2, CCND1

Products for genes affiliated with Laryngeal Squamous Cell Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet