MCID: LRY019
MIFTS: 62

Laryngitis malady

Summaries for Laryngitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

MalaCards: Laryngitis, also known as laryngitis nos, is related to laryngeal squamous cell carcinoma and squamous cell carcinoma. An important gene associated with Laryngitis is ICK (intestinal cell (MAK-like) kinase), and among its related pathways are Validated targets of C-MYC transcriptional activation and Integrated Pancreatic Cancer Pathway. The drug guaifenesin and the compounds progesterone and vegf have been mentioned in the context of this disorder. Affiliated tissues include lymph node, endothelial and thyroid, and related mouse phenotypes are mortality/aging and cellular.

Wikipedia:63 Laryngitis is an inflammation of the larynx. It causes hoarse voice or temporary complete loss of the... more...

Aliases & Classifications for Laryngitis

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

laryngitis 8 10 60
laryngitis nos 8


External Ids:

Disease Ontology8 DOID:3437
NCIt39 C26811
SNOMED-CT56 45913009
MeSH34 D007827

Related Diseases for Laryngitis

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17GeneCards, 18GeneDecks
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Diseases in the Laryngitis family:

Viral Laryngitis Chronic Laryngitis
Acute Laryngitis

Diseases related to Laryngitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 506)
idRelated DiseaseScoreTop Affiliating Genes
1laryngeal squamous cell carcinoma31.7GSTT1, GSTM1, TP53, TERT, BIRC5, NME1
2squamous cell carcinoma31.7NME1, EIF4E, MKI67, CCND1
3papilloma30.7TP53, PCNA, IFI27
4rhabdomyosarcoma30.3TP53, MMP14, EIF4E
5chondrosarcoma30.3MMP14
6adenoma30.2GSTT1, GSTM1, TP53, TERT, BIRC5, NME1
7sarcoma30.2GSTM1, TP53, TERT, MKI67
8papillary carcinoma30.2NME1, MKI67, VEGFC, IFI27
9adenoid cystic carcinoma30.1PCNA, MKI67, CCND1
10adenocarcinoma30.1GSTT1, GSTM1, TP53, TERT, BIRC5, NME1
11cervical squamous cell carcinoma30.1MMP14, MKI67
12papillary thyroid carcinoma30.1VEGFC, IFI27, CCND1
13leiomyosarcoma30.1TP53
14laryngeal benign neoplasm30.0GSTT1, GSTM1, TERT, NME1, MMP14, NAT2
15lung cancer29.9GSTM1, TP53, TERT, BIRC5, NME1, MMP14
16retinoblastoma29.9TP53, TERT, BIRC5, NME1, PCNA, MKI67
17breast cancer29.9CTSD, AURKA, IFI27, CCND1
18colon adenocarcinoma29.9EIF4E
19herpes simplex29.9CTSD
20parathyroid adenoma29.9CCND1
21asthma29.8GSTT1, GSTM1, MMP14, NAT2
22leiomyoma29.8PCNA, MKI67, BSG
23arthritis29.8MMP14
24hepatoblastoma29.8BIRC5
25melanoma29.6GSTT1, TP53, TERT, BIRC5, NME1, MMP14
26cervical cancer29.6GSTT1, GSTM1, TP53, TERT, BIRC5, NME1
27leukemia29.6GSTT1, GSTM1, TP53, TERT, BIRC5, NME1
28lung adenocarcinoma29.6GSTT1, GSTM1, TP53, TERT, BIRC5, MMP14
29thyroid cancer29.6TERT, NME1, MMP14, VEGFC, CTSD, IFI27
30lung small cell carcinoma29.6GSTT1, GSTM1, TP53, VEGFC, CTSD
31non-hodgkin lymphoma29.6GSTT1, GSTM1, BIRC5, NAT2, CCND1
32smooth muscle tumor29.6NME1, PCNA, MKI67, IFI27
33acute leukemia29.6GSTT1, GSTM1, TERT, BIRC5
34pancreatic cancer29.6TERT, BIRC5, MMP14, CCND1
35gastrointestinal stromal tumor29.6PCNA, MKI67, IFI27
36ischemia29.6MMP14, VEGFC, BSG, CTSD
37inverted papilloma29.6PCNA, MKI67, IFI27
38myeloid leukemia29.6BIRC5, NME1
39parathyroid carcinoma29.6MKI67, CCND1
40malignant mesothelioma29.6NAT2
41tongue cancer29.6TERT
42meningioma29.6PCNA, MKI67
43cleft palate29.6GSTM1
44measles29.6AURKA
45angiosarcoma29.6VEGFC
46laryngeal carcinoma11.3
47laryngeal tuberculosis10.8
48tuberculosis10.8
49laryngeal disease10.7
50chronic laryngitis10.7

Graphical network of the top 20 diseases related to Laryngitis:



Diseases related to laryngitis

Clinical Features for Laryngitis

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Drugs & Therapeutics for Laryngitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Laryngitis

Drug clinical trials:

Search ClinicalTrials for Laryngitis

Search NIH Clinical Center for Laryngitis

Search CenterWatch for Laryngitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Laryngitis

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Anatomical Context for Laryngitis

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32MalaCards
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MalaCards organs/tissues related to Laryngitis:

32
Lymph node, Endothelial, Thyroid, Lung, Skin, Colon, Testes, Tongue, Heart, Bone, T cells, Trachea, Breast, Prostate, Tonsil, Pituitary, Small intestine, Fetal lung, Smooth muscle, Monocytes, Myeloid, Eye, Brain, Liver, Appendix, Bone marrow

Animal Models for Laryngitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Laryngitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076812.2TP53, CCND1, AURKA, CTSD, BSG, VEGFC
2MP:000538411.9CCND1, AURKA, CTSD, PCNA, EIF4E, MMP14
3MP:000537811.8BSG, CTSD, AURKA, CCND1, MID1, PCNA
4MP:000538711.4CCND1, CTSD, BSG, VEGFC, PCNA, MMP14
5MP:000537911.1TP53, TERT, NME1, CTSD, CCND1
6MP:000537611.1CTSD, NAT2, MMP14, GSTT1
7MP:000200611.0CCND1, AURKA, EIF4E, NME1, TERT

Publications for Laryngitis

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50PubMed
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Articles related to Laryngitis:

(show top 50)    (show all 2868)
idTitleAuthorsYear
1
MicroRNA-106b regulates the tumor suppressor RUNX3 in laryngeal carcinoma cells. (23912048)
2013
2
Acute laryngitis superimposed on chronic laryngitis. (23460211)
2013
3
Laryngeal plexiform neurofibroma in a child. (23780601)
2013
4
Laryngeal anisakiasis: an unusual cause of foreign-body sensation in the throat. (22449857)
2012
5
Expression of programmed cell death 4 and its correlation with proliferation and apoptosis in laryngeal squamous cell carcinoma]. (22675936)
2012
6
Nuclear BMI-1 expression in laryngeal carcinoma correlates with lymph node pathological status. (23031716)
2012
7
Laryngeal neuropathy of Charcot-Marie-Tooth disease: further observations and novel mutations associated with vocal fold paresis. (19950375)
2010
8
Expression and significance of integrins subunits in laryngeal squamous cell carcinoma]. (20942236)
2010
9
Polymorphic variants of folate metabolism genes and the risk of laryngeal cancer. (19649727)
2010
10
Reflux-associated laryngitis and laryngopharyngeal reflux: a gastroenterologist's point of view. (19439955)
2009
11
Let-7a microRNA functions as a potential tumor suppressor in human laryngeal cancer. (19787239)
2009
12
Significance of the counteracting oxidative and antioxidative systems in the pathogenesis of laryngeal carcinoma. (19442365)
2009
13
Overexpression of Cap43 gene in supraglottic laryngeal squamous cell carcinoma. (19847997)
2009
14
Quantification of myosin heavy chain RNA in human laryngeal muscles: differential expression in the vertical and horizontal posterior cricoarytenoid and thyroarytenoid. (18091331)
2008
15
Loss of heterozygosity for Rb locus and pRb immunostaining in laryngeal cancer: a clinicopathologic, molecular and immunohistochemical study. (19141402)
2008
16
Laryngeal carcinoma in nonsmoking patients. (18771070)
2008
17
Laryngeal pleomorphic rhabdomyosarcoma. (17481838)
2007
18
Expression and significance of TGF-beta1 and HSP70 in human laryngeal squamous cell carcinoma]. (17802821)
2007
19
The role of host immune response and apoptosis in patients with laryngeal squamous cell carcinoma. (17264532)
2007
20
Expression of connective tissue growth factor (CTGF), osteopontin (OPN) and clinical significances in the laryngeal squamous cell carcinoma tissues]. (17441427)
2007
21
Impact of patient and professional diagnostic delays on the risk of recurrence in laryngeal carcinoma. (15839868)
2005
22
Research of fibronectin, p53 and Ezrin protein with occurrence, progress and prognosis in the primary laryngeal carcinoma by the tissuechip technology]. (15835821)
2004
23
Association between p53 gene mutations and tobacco and alcohol exposure in laryngeal squamous cell carcinoma. (15023836)
2004
24
Effect of laryngoplasty on respiratory noise reduction in horses with laryngeal hemiplegia. (15253083)
2004
25
Prognostic significance of P27 and cyclin D1 co-expression in laryngeal squamous cell carcinoma: possible target for novel therapeutic strategies. (15675466)
2004
26
Differential expression of retinoic acid receptor beta (RARbeta) and the AP-1 transcription factor in normal, premalignant and malignant human laryngeal tissues. (15010078)
2004
27
The biology and management of laryngeal neurofibroma. (15611399)
2004
28
p53, Ki67 and cyclin D1 as prognosticators of lymph node metastases in laryngeal carcinoma. (14551784)
2003
29
Health-related quality of life five years after diagnosis of laryngeal carcinoma. (12873678)
2003
30
Tumor angiogenesis as a predictive marker for organ preservation in patients with advanced laryngeal carcinoma. (12150616)
2002
31
Serotonin mediated cluster headache, trigeminal neuralgia, glossopharyngeal neuralgia, and superior laryngeal neuralgia with SAD chronicity. (11579658)
2001
32
Nm23 and cathepsin D expression in laryngeal carcinomas. (11080791)
2000
33
Herpes simplex viral laryngitis. (10855577)
2000
34
Expression of TGF-beta 1 protein and mRNA and the effect on the tissue remodeling in laryngeal carcinomas. (10628385)
1999
35
Association of arylamine N-acetyltransferases NAT1 and NAT2 genotypes to laryngeal cancer risk. (10208649)
1999
36
Laryngeal paralysis in a rottweiler with neuroaxonal dystrophy. (9404606)
1997
37
Nucleolar organizer regions activity in lymphocytes of patients with laryngeal carcinoma. (8003288)
1993
38
Hypnotherapeutic intervention for voice disorders related to recurring juvenile laryngeal papillomatosis. (1582727)
1992
39
Combined CO2-laser and alfa recombinant interferon treatment in five children with juvenile laryngeal papillomatosis. (2166413)
1990
40
Microsurgery in otolaryngology: benign laryngeal disease. (2687615)
1989
41
The viewbox. Juvenile laryngeal papillomatosis. (2902061)
1988
42
Blepharospasm and oromandibular-laryngeal-cervical dystonia: a controlled trial of botulinum A toxin therapy. (3041763)
1988
43
Acid posterior laryngitis. Aetiology, histology, diagnosis and treatment. (6512397)
1984
44
Laryngeal problems in the scimitar syndrome. (6615324)
1983
45
Laryngeal cyst (filled laryngocele): a laryngographic diagnosis. (5824246)
1969
46
Laryngitis and its relation to the nose and sinuses. (14823979)
1951
47
Laryngeal tuberculosis; observations based on an experience of 28 years with laryngeal tuberculosis. (18885450)
1948
48
Influenzal laryngitis. (18913522)
1948
49
Laryngeal Tuberculosis. (19975970)
1912
50
Remarks ON COMPLETE VOCAL REST DURING THE SANATORIUM TREATMENT OF LARYNGEAL TUBERCULOSIS. (20763283)
1907

Genetic Variations for Laryngitis

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Expression for genes affiliated with Laryngitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Laryngitis

Search GEO for disease gene expression data for Laryngitis.

Pathways for genes affiliated with Laryngitis

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37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 4Cell Signaling Technology, 51QIAGEN, 49PharmGKB, 53Reactome
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Compounds for genes affiliated with Laryngitis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Laryngitis according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2416.6TP53, CCND1, CTSD, BIRC5, NME1, MMP14
2vegf4412.6IFI27, TERT, TP53, CCND1, CTSD, BSG
3cisplatin44 49 59 1115.5CCND1, IFI27, CTSD, PCNA, EIF4E, BIRC5
4oligonucleotide4412.5IFI27, BIRC5, CCND1, NME1, GSTT1, TERT
5paraffin4412.4CTSD, VEGFC, PCNA, NME1, MKI67, MMP14
6thymidine44 2413.4TP53, MKI67, CTSD, VEGFC, CCND1, MMP14
7retinoic acid44 2413.3PCNA, TP53, VEGFC, IFI27, CCND1, EIF4E
8oxygen44 2413.2CTSD, MMP14, EIF4E, IFI27, TERT, GSTT1
9ly2940024412.1BIRC5, TP53, IFI27, BSG, VEGFC, EIF4E
10doxorubicin44 49 1114.1IFI27, CTSD, TP53, MKI67, CCND1, GSTT1
11lactate4412.1MMP14, GSTM1, PCNA, NME1, MKI67, BIRC5
12testosterone44 59 11 2415.1TERT, CTSD, GSTM1, BIRC5, PCNA, MKI67
13threonine4412.0BIRC5, MMP14, CCND1, AURKA, BSG, MKI67
14p0024412.0MKI67, MMP14, NME1, BIRC5, GSTM1, IFI27
15thymidylate4412.0GSTM1, IFI27, PCNA, BIRC5, TERT, TP53
165fluorouracil4411.9NME1, BIRC5, TP53, TERT, PCNA, GSTM1
17paclitaxel44 49 1113.8TERT, CCND1, IFI27, AURKA, CTSD, BIRC5
18n acetylcysteine4411.8CCND1, IFI27, EIF4E, BIRC5, TERT, PCNA
19pd 98,0594411.7IFI27, CCND1, VEGFC, EIF4E, MMP14, BIRC5
20steroid4411.7NME1, EIF4E, MKI67, CTSD, BIRC5, IFI27
21adpribose4411.7TERT, TP53, PCNA, BIRC5, IFI27, CCND1
22genistein44 28 59 2 11 2416.7BIRC5, MMP14, IFI27, CCND1, CTSD, PCNA
23mg 13244 5912.6PCNA, TP53, EIF4E, CCND1, BIRC5, IFI27
24cyclophosphamide44 49 1113.6GSTT1, MKI67, GSTM1, CTSD, TP53, PCNA
25serine4411.6NME1, MMP14, EIF4E, MKI67, AURKA, CCND1
26arsenite44 2412.6CCND1, PCNA, EIF4E, TERT, BIRC5, TP53
27norcantharidin4411.6CCND1, BIRC5, PCNA, MKI67, IFI27
28chi 24411.6IFI27, MKI67, NME1, GSTM1, GSTT1
29p000014411.5BIRC5, MMP14, MKI67, VEGFC, CCND1
30phosphatidylinositol4411.5CCND1, TERT, MMP14, IFI27, CTSD, VEGFC
31dutp4411.5PCNA, TP53, CCND1, BIRC5, MKI67
32sulindac44 1112.5IFI27, CCND1, PCNA, BIRC5, TP53
33roscovitine4411.5TP53, CCND1, IFI27, PCNA, BIRC5
34methotrexate44 49 1113.5GSTM1, CCND1, MKI67, BIRC5, NAT2, PCNA
35trastuzumab44 49 1113.5CCND1, VEGFC, BIRC5, IFI27, CTSD
36agar4411.5CTSD, CCND1, BIRC5, EIF4E, MMP14, NME1
37tamoxifen44 49 28 1114.4MKI67, BIRC5, CCND1, CTSD
388-oxo-dg4411.3PCNA, TP53, GSTT1, GSTM1
39etoposide44 49 59 1114.3TERT, CTSD, EIF4E
40estradiol44 11 2413.3CTSD, BIRC5, VEGFC, MKI67
41p0034411.3IFI27, GSTM1, GSTT1, CTSD, MKI67
42aflatoxin b144 2412.3GSTM1, GSTT1, NAT2, TP53
43acetone4411.2GSTT1, CCND1, GSTM1, MKI67
44nitric oxide44 11 2413.2CTSD, BIRC5, EIF4E, NAT2, MKI67, VEGFC
45drugs for treatment of tuberculosis4911.2GSTT1, GSTM1, NAT2
46nimbolide4411.2CCND1, PCNA, BIRC5
47crcs4411.1BIRC5, TP53, NME1, CCND1
48indole-3-carbinol4411.0TP53, IFI27, BIRC5, CCND1
49vincristine44 49 1112.9MKI67, CCND1, GSTM1
50adriamycin4410.9CCND1, CTSD, BIRC5, TERT

GO Terms for genes affiliated with Laryngitis

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16Gene Ontology
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Cellular components related to Laryngitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582911.5GSTT1, CCND1, ICK, AURKA, NAT2, EIF4E
2melanosomeGO:04247010.9MMP14, BSG, CTSD

Biological processes related to Laryngitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:09039910.7TP53, TERT
2mitotic G1 DNA damage checkpointGO:03157110.4TP53, CCND1

Molecular functions related to Laryngitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.2TP53, CCND1, ICK, AURKA, CTSD, BSG
2protein kinase bindingGO:01990111.0TP53, NME1, AURKA, CCND1
3enzyme bindingGO:01989910.7CCND1, BIRC5, TP53, GSTM1

Products for genes affiliated with Laryngitis

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Laryngitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet