Laryngitis malady

Disease Ontology: A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.⁶

MalaCards: Laryngitis, also known as laryngitis (disorder), is related to carcinoma and laryngeal squamous cell carcinoma. An important gene associated with Laryngitis is MID1 (midline 1 (Opitz/BBB syndrome)), and among its related pathways are Molecular Mechanisms of Cancer and Focal adhesion. The drug guaifenesin and the compounds butyrate and wortmannin have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and spinal cord, and related mouse phenotypes are muscle and cellular.

Wikipedia: Laryngitis is an inflammation of the larynx. It causes hoarse voice or the complete loss of the voice...⁴⁴ more...

Aliases & Descriptions:

laryngitis 6 8 43 laryngitis (disorder) 6

laryngitis nos 6

Diseases related to laryngitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 964)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	66.6	ZNF706, PIK3CA, PIM1, SH3GL2, PDCD4, RECQL4
2	laryngeal squamous cell carcinoma	64.1	ZNF706, PIM1, RECQL4, SFN, PCNA, PCDH17
3	laryngeal carcinoma	62.7	SH3GL2, PDCD4, RELA, KIF14, PCNA, BTG2
4	laryngeal cancer	57.4	PCNA, RB1, SERPINB3, SERPINA6, SERPINB2, SERPINA3
5	cervicitis	48.8	PIK3CA, PDCD4, RECQL4, RELA, KIT, KIR2DS4
6	prostatitis	48.4	PIK3CA, PIM1, PDCD4, RECQL4, RELA, KIT
7	esophagitis	46.9	PIK3CA, PIM1, PDCD4, RELA, KIT, SFN
8	hypoxia	44.3	PIK3CA, PIM1, PDCD4, RELA, KIT, PCNA
9	squamous cell carcinoma	43.2	RBP1, SERPINB3, LGALS1, LGALS3, LGALS8, CD44
10	thyroiditis	42.7	PIK3CA, RELA, KIT, SFN, PCNA, RB1
11	neuronitis	41.9	PIK3CA, PIM1, SH3GL2, RELA, KIT, KIR2DS4
12	papilloma	40.4	KIR3DL1, PCNA, RB1, SERPINB3, SERPINB2, VIM
13	meningioma	40.2	RECQL4, PCNA, RB1, SERPINB3, SETD2, SERPINB2
14	retinoblastoma	38.6	PIK3CA, KIT, KIF14, PCNA, RB1, SERPINB2
15	leukoplakia	35.6	PCNA, NAT2, BRCA1, RARB, BCL2, BAG1
16	pharyngitis	35.4	PIK3CA, PCNA, VIM, NAT1, NAT2, VEGFA
17	keratosis	33.1	PIK3CA, PCNA, RB1, MYC, BCL2, S100A2
18	ataxia	32.1	PIK3CA, SH3GL2, PCNA, PCDH17, BTD, SETD2
19	xeroderma pigmentosum	31.5	RECQL4, PCNA, BRCA1, RAD23B, BCL2, BAX
20	noma	31.5	PIK3CA, KIT, PCNA, RB1, VIM, VEGFA
21	basaloid squamous cell carcinoma	30.8	PCNA, MYC, BIRC5, BCL2L1, BAX, S100A1
22	paraganglioma	30.5	KIT, PCNA, VIM, BSG, BNIP3, BCL2
23	neuroendocrine carcinoma	30.1	KIT, PCNA, VIM, VEGFA, BCL2, CHEK2
24	epidermolysis bullosa	29.4	VIM, MUC1, JUN, CD79A, CD36, CDKN2A
25	ataxia telangiectasia	29.4	PIK3CA, PCNA, VIM, BRCA1, BRCA2, MYC
26	amyloidosis	28.6	SERPINA3, MYOM2, CLU, BCL2, CD79A, CD40LG
27	hepatoblastoma	28.6	PIK3CA, PCNA, RB1, SERPINA6, SERPINE1, SERPINA3
28	sudden infant death syndrome	27.6	VEGFA, S100A1, GSTM1, GSTT1, IL10, IL1B
29	blindness	26.7	SERPINE1, VEGFA, CLU, KDR, CHKB, MTHFR
30	adenocarcinoma	26.6	PIK3CA, PIM1, RELA, KIT, SFN, PCNA
31	hepatocellular carcinoma	26.5	PIK3CA, PDCD4, RELA, KIT, KIR3DL1, PCNA
32	neuropathy	26.3	BTD, SERPINE1, VIM, VEGFA, CHKB, MTHFR
33	leukemia	26.3	PIK3CA, PIM1, SH3GL2, PDCD4, RECQL4, RELA
34	gastric cancer	26.2	PIK3CA, PIM1, PDCD4, RELA, KIT, PCNA
35	lung carcinoma	26.2	PIK3CA, PCNA, BTG2, RB1, SERPINB3, SETD2
36	colon cancer	25.9	PIK3CA, PDCD4, RELA, SFN, PCNA, RB1
37	melanoma	25.3	PIK3CA, PIM1, RELA, KIT, KIR2DS4, KIR3DL1
38	pancreatitis	25.3	PIK3CA, PIM1, RELA, KIT, KIF14, SFN
39	breast carcinoma	24.7	PIK3CA, SH3GL2, KIT, SFN, PCNA, BTG2
40	oral squamous cell carcinoma	24.1	PIK3CA, PIM1, PDCD4, SFN, PCNA, RB1
41	ovarian carcinoma	24.0	PIK3CA, PDCD4, RELA, KIT, PCNA, RB1
42	adenoma	23.7	PIK3CA, PDCD4, KIT, PCNA, RB1, SETD2
43	esophageal squamous cell carcinoma	23.1	PIK3CA, PIM1, RELA, KIT, SFN, PCNA
44	cervical cancer	23.1	PIK3CA, RECQL4, RELA, SFN, PCNA, RB1
45	esophageal cancer	22.7	PIK3CA, PDCD4, PCNA, RB1, SERPINB3, SERPINA3
46	thyroid carcinoma	22.3	PIK3CA, RECQL4, SFN, PCNA, RB1, SERPINB3
47	endometrial cancer	21.9	PIK3CA, PDCD4, SFN, PCNA, RB1, SETD2
48	epithelial ovarian cancer	21.8	PIK3CA, RELA, SFN, RB1, SERPINB5, SERPINB2
49	bladder carcinoma	21.8	PIK3CA, SFN, PCNA, RB1, SERPINB5, SERPINB2
50	sarcoma	21.7	PIK3CA, RELA, KIT, PCNA, RB1, SETD2

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 guaifenesin

MalaCards organs/tissues related to laryngitis:

²²

MGI Mouse Phenotypes related to laryngitis:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle phenotype	MP:0005369	INF	PIK3CA, RELA, , BTD, RB1, SERPIND1
2	cellular phenotype	MP:0005384	INF	PIK3CA, PIM1, RECQL4, RELA, , SFN
3	immune system phenotype	MP:0005387	INF	PDCD4, RECQL4, , SFN, RBP1, SERPINA6
4	mortality/aging	MP:0010768	INF	PIK3CA, PDCD4, RECQL4, RELA, SFN, RB1
5	nervous system phenotype	MP:0003631	INF	RELA, , BTG2, RB1, RBP1, BRCA1
6	reproductive system phenotype	MP:0005389	INF	PIK3CA, PDCD4, SFN, RBP1, NAT1, BRCA1
7	hematopoietic system phenotype	MP:0005397	INF	PIM1, RECQL4, , SFN, PCNA, RBP1
8	cardiovascular system phenotype	MP:0005385	INF	PIK3CA, RELA, , RB1, SETD2, SERPIND1
9	embryogenesis phenotype	MP:0005380	INF	PIK3CA, RECQL4, , SFN, SETD2, SERPINB5
10	integument phenotype	MP:0010771	INF	RECQL4, RELA, , SFN, BTD, RB1
11	respiratory system phenotype	MP:0005388	INF	BRCA1, MYCN, CD1D, F13A1, CALCA,
12	renal/urinary system phenotype	MP:0005367	INF	PDCD4, , BTD, SERPIND1, SERPINA6, BRCA1
13	tumorigenesis	MP:0002006	INF	PIK3CA, PDCD4, RECQL4, , SFN, RB1
14	craniofacial phenotype	MP:0005382	INF	RECQL4, , MYCN, RAD23B, LBR, CDKN1C
15	digestive/alimentary phenotype	MP:0005381	INF	RECQL4, , SFN, RB1, BRCA1,
16	limbs/digits/tail phenotype	MP:0005371	INF	RECQL4, RELA, , SFN, RB1, BRCA1
17	no phenotypic analysis	MP:0003012	13.7	PCNA, RB1, SERPINA6, VEGFA, MYC, BMF
18	other phenotype	MP:0005395	11.9	RARB, CLU, KDR, CDKN2A, CD40LG, ITGB1
19	adipose tissue phenotype	MP:0005375	10.2	PIK3CA, RB1, SERPINE1, BRCA1, MYC, RAD23B
20	liver/biliary system phenotype	MP:0005370	INF	, SFN, RBP1, SERPINA6, VEGFA, MYCN
21	normal phenotype	MP:0002873	INF	RELA, NAT1, BRCA1, , VEGFA, VCAN
22	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CA, RELA, , BTD, RB1, RBP1
23	growth/size phenotype	MP:0005378	INF	PIK3CA, PIM1, RECQL4, RELA, , SFN
24	behavior/neurological phenotype	MP:0005386	INF	PIK3CA, , BTD, RB1, SERPINA6, VIM
25	endocrine/exocrine gland phenotype	MP:0005379	INF	PDCD4, SFN, BRCA1, , RAD23B, XDH
26	hearing/vestibular/ear phenotype	MP:0005377	INF	, SFN, RB1, RBP1, MYC, RARB
27	vision/eye phenotype	MP:0005391	INF	PIK3CA, RECQL4, RELA, , SFN, BTD
28	skeleton phenotype	MP:0005390	INF	RELA, , SFN, BTG2, RB1, BRCA1
29	pigmentation phenotype	MP:0001186	INF	RECQL4, , BTD, RB1, RBP1, BRCA1

Articles related to laryngitis:

(show top 50)    (show all 793)

id	Title	Authors	Year	Affiliating Genes
1	Expression of microtubule-associated protein 1 light chain 3 in laryngeal carcinoma]. (21845828)	Wan B.... Kong W.	2011	MAP1LC3A
2	Fibronectin induces matrix metalloproteinase-9 (MMP-9 ) in human laryngeal carcinoma cells by involving multiple signaling pathways. (20638438)	Sen T.... Chatterjee A.	2010	MMP9, FN1
3	Prognostic significance of fascin-1 and E-cadherin ex pression in laryngeal squamous cell carcinoma. (19741544)	Zou J.... Liu S.	2010	CDH1, FSCN1
4	Expression and pathobiological significance of Col I , Col IV and Fn in laryngeal squamous cell carcinomas (20359090)	Zhang H.... Shang W.	2009	COL1A1, FN1, CD36
5	Cyclin D1 and cancer development in laryngeal premalignancy patients. (19139013)	Papadimitrakopoulou V.... Hong W.K.	2009	CCND1, IFNA1
6	Role of ATP in the ROS-mediated laryngeal airway hyperreactivity induced by laryngeal acid-pepsin insult in anesthetized rats. (19246655)	Tsai T.L.... Kou Y.R.	2009	ADA, CANT1
7	The expression and significance of integrin beta1 and focal adhesion kinase and its clinical value in laryngeal carcinoma (19297850)	Wei G.... Zhang X.	2008	PTK2, ITGB1
8	Combined antitumor activity of cucurbitacin B and doc etaxel in laryngeal cancer. (18442812)	Liu T.... Ji W.	2008	BCL2, CCNB1
9	Myosin heavy chain isoforms in human laryngeal muscle s: an expression study based on gel electrophoresis. (18698498)	Toniolo L.... Reggiani C.	2008	MYH6
10	Study on relationship between intratumoral lymphangiogenesis of laryngeal squamous cell carcinoma and lymphatic metastasis (18652308)	Huangfu H.... Zhang C.	2008	VEGFC
11	Combined p14ARF and antisense EGFR potentiate the efficacy of adenovirus-mediated gene therapy in laryngeal squamous cell carcinoma (LSCC). (17328665)	Xian J.... Liu S.	2007	EGFR
12	The expressions and significance of CK2 in normal laryngeal mucosa, laryngeal precancerosis and laryngeal squamous cell carcinoma (18062282)	Wu L.... Liu B.	2007	CSNK2A1, CSNK2B
13	Expression and role of survivin in laryngeal squamous cell carcinoma and laryngeal papilloma in adults (17634026)	Xie H.... Song F.	2007	BIRC5
14	Intratumoral delivery of paclitaxel-loaded poly(lacti c-co-glycolic acid) microspheres for Hep-2 laryngeal squamous cell carcinoma xe nografts. (17351398)	Xie M.... Yao M.	2007	FGF2, VEGFA
15	Expressions of NF-kappaB p65 in laryngeal carcinoma and normal mucous membrane and its clinical significance]. (17969521)	Zhang L.... Yu L.	2007	RELA
16	Elemene in the treatment of the transplantable model of human laryngeal squamous carcinoma in nude mice (17634027)	Cao Z.... Ji W.	2007	FLT4, VEGFC
17	Soluble EMMPRIN (extra-cellular matrix metalloproteinase inducer) stimulates the migration of HEp-2 human laryngeal carcinoma cells, accompanied by increased MMP-2 production in fibroblasts. (18431027)	Hanata K.... Ishikawa K.	2007	MMP2, BSG
18	Clinical significance and expression of FLIP and PTEN protein in laryngeal squamous cell carcinoma (17441421)	Wei Z.... Zhou X.	2007	PTEN, CFLAR
19	Association between genetic polymorphism in xeroderma pigmentosum G gene and risks of laryngeal and hypopharyngeal carcinomas (17121236)	Wen S.X.... Lin D.X.	2006	ERCC5
20	Curcumin, a potential inhibitor of MMP-2 in human laryngeal squamous carcinoma cells HEp2. (17341208)	Mitra A.... Das B.R.	2006	MMP2, MMP9, PTK2
21	Expression of two kinds of tumor correlation protein in laryngeal carcinoma and precancerous lesions (17345711)	Zhao H.C.... He X.G.	2006	PTEN, SKP2
22	Hyaluronidase and CD44 hyaluronan receptor expression in squamous cell laryngeal carcinoma. (16713680)	Christopoulos T.A.... Vynios D.H.	2006	CD44, HYAL1, SPAM1
23	The expression and correlation of eIF4E and VEGF in laryngeal squamous cell carcinoma (16124648)	Wang B.... Chen Y.	2005	EIF4E, VEGFA
24	Bcl-2 expression predicts radiotherapy failure in laryngeal cancer. (15928664)	Nix P.... Stafford N.	2005	BAX
25	Methylation-associated silencing of death-associated protein kinase gene in laryngeal squamous cell cancer. (16094112)	Kong W.J.... Zhang D.	2005	DAPK1
26	The expression of p21(WAF1/CIP1) and PCNA in hypopharyngeal and laryngeal squamous cell carcinomas (15844604)	Li X.... Dong P.	2005	PCNA
27	The role of E-cadherin/catenin complex in laryngeal cancer. (16404343)	Mittari E.... Charalabopoulos K.	2005	CDH1
28	p53, Ki67 and cyclin D1 as prognosticators of lymph node metastases in laryngeal carcinoma. (14551784)	Mielcarek-Kuchta D.... Golusinski W.	2003	TP53, CCND1, MKI67
29	Differential expression of the epithelial membrane protein 1 of laryngeal carcinoma (12905607)	Liu Y.H.... Liu Z.H.	2003	EMP1
30	Lack of expression of galectin-3 is associated with a poor outcome in node-negative patients with laryngeal squamous-cell carcinoma. (12228204)	Piantelli M.... Ranelletti F.O.	2002	LGALS3
31	Lack of Bcl10 gene mutations in laryngeal squamous cell carcinoma. (12389689)	Ronchetti D.... Pignataro L.	2002	BCL10
32	Genetic polymorphism of cytochrome P4501A1 and susceptibility to laryngeal carcinoma (12772461)	Lei D.... Liu D.	2002	CYP1A1
33	Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk. (12359356)	To-Figueras J.... Corbella J.	2002	GSTP1, GSTT1, GSTM3
34	Prognostic significance of p16INK4a alterations and 9p21 loss of heterozygosity in locally advanced laryngeal squamous cell carcinoma. (12124774)	Bazan V.... Russo A.	2002	CDKN2A
35	Prognostic significance of Bcl-2 and p53 expression in advanced laryngeal squamous cell carcinoma. (11400228)	Friedman M.... Coon J.S.	2001	TP53, BCL2
36	Prognostic value of the expression of p53 and bcl-2 in patients with laryngeal carcinoma. (11829192)	Klatka J.	2001	TP53, BCL2
37	Altered MUC1 and MUC2 glycoprotein expression in laryngeal cancer. (11226957)	Jeannon J.P.... Wilson J.A.	2001	MUC2
38	Human papilloma virus infection and expression of p16 protein in laryngeal papilloma and laryngeal carcinoma (12761910)	Li J.... Zhou A.	2001	CDKN2A
39	Role of P53, nm23 proteins and vascular endothelial growth factor in angiogenesis and metastasis of laryngeal cancer (12768677)	Cheng W.... Guo X.	2000	TP53, VEGFA, NME1
40	The study of p16 gene mutation and methylation in laryngeal squamous cell carcinoma (12768709)	Bai S.... Sun K.	2000	CDKN2A
41	Prognostic significance of EGFR and p53 expression, and angiogenesis in laryngeal squamous cell carcinoma (10191626)	Watanabe H.... Miyata H.	1999	EGFR, TP53
42	Comparison of adherence to and penetration of a human laryngeal epithelial cell line by group A streptococci of various M protein types. (10219591)	Hagman M.M.... Stevens D.L.	1999	MYOM2
43	Serum protein fractions in patients with laryngeal cancer undergoing radiation therapy. Possibility as a prognostic factor (10199063)	Onizuka K.... Matsumoto I.	1999	CD40LG, CP, AMBP
44	DNA content, expression of proliferating cell nuclear antigen and surgical margins in locally advanced laryngeal cancer (11938851)	Wang B.... Shi Q.	1998	PCNA
45	Study of detecting p53 gene of laryngeal carcinoma on paraffin-embedded tissue sections by in situ polymerase chain reaction (10073037)	Xie M.	1997	TP53
46	p53 mutation as a prognostic marker in advanced laryngeal carcinoma. Department of Veterans Affairs Laryngeal Cancer Cooperative Study Group. (9193221)	Bradford C.R.... Wolf G.T.	1997	TP53
47	Analysis of retinoic acid receptor beta expression in normal and malignant laryngeal mucosa by a sensitive and routine applicable reverse transcription-polymerase chain reaction enzyme-linked immunosorbent assay method. (9815607)	Castillo L.... Pierrefite V.	1997	RARB
48	Serum dihydrotestosterone versus total testosterone values of patients with laryngeal carcinomas and chronic laryngitis (8766382)	Kleemann D.... Kunkel S.	1996	SRD5A1
49	Epithelial membrane antigen and S-100 protein-labeled cells in primary and metastatic laryngeal carcinomas. (1468915)	Nakashima T.... Katsuta Y.	1992	S100B, MUC1
50	Cathepsin D in primary squamous laryngeal tumors: correlation with clinico-pathological parameters and receptor status. (1483262)	Ferrandina G.... Mancuso S.	1992	CTSD

Genes related to laryngitis according to GeneCards:

(show top 50)    (show all 459)

id	Symbol	Description	Score	GeneCards Section Context
1	MID1	midline 1 (Opitz/BBB syndrome)	11.0	Summaries
2	GGNBP2	gametogenetin binding protein 2	11.0	Aliases & Descriptions, UniProt Related
3	LAP	Laryngeal adductor paralysis	11.0	Aliases & Descriptions
4	ICK	intestinal cell (MAK-like) kinase	11.0	Aliases & Descriptions
5	IFI27	interferon, alpha-inducible protein 27	11.0	Publications
6	NME1	NME/NM23 nucleoside diphosphate kinase 1	11.0	Publications
7	PCNA	proliferating cell nuclear antigen	11.0	Publications
8	CTSD	cathepsin D	11.0	Publications
9	NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	11.0	Publications
10	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
11	TERT	telomerase reverse transcriptase	11.0	Publications
12	GSTT1	glutathione S-transferase theta 1	11.0	Publications
13	GSTM3	glutathione S-transferase mu 3 (brain)	11.0	Publications
14	BSG	basigin (Ok blood group)	11.0	Publications
15	MMP14	matrix metallopeptidase 14 (membrane-inserted)	11.0	Publications
16	BIRC5	baculoviral IAP repeat containing 5	11.0	Publications
17	CCND1	cyclin D1	11.0	Publications
18	VEGFC	vascular endothelial growth factor C	11.0	Publications
19	BCL2	B-cell CLL/lymphoma 2	11.0	Publications
20	CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	11.0	Publications
21	RB1	retinoblastoma 1	11.0	Publications
22	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0	Publications
23	TP53	tumor protein p53	11.0	Publications
24	GSTM1	glutathione S-transferase mu 1	11.0	Publications
25	EGFR	epidermal growth factor receptor	11.0	Publications
26	BAK1	BCL2-antagonist/killer 1	11.0	Publications
27	LGALS1	lectin, galactoside-binding, soluble, 1	11.0	Publications
28	HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	11.0	Publications
29	FLT4	fms-related tyrosine kinase 4	11.0	Publications
30	CCNA2	cyclin A2	11.0	Publications
31	CD44	CD44 molecule (Indian blood group)	11.0	Publications
32	AURKA	aurora kinase A	11.0	Publications
33	EIF4E	eukaryotic translation initiation factor 4E	11.0	Publications
34	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications
35	CP	ceruloplasmin (ferroxidase)	11.0	Publications
36	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
37	HSPB1	heat shock 27kDa protein 1	11.0	Publications
38	GSTP1	glutathione S-transferase pi 1	11.0	Publications
39	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11.0	Publications
40	VEGFA	vascular endothelial growth factor A	11.0	Publications
41	CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	11.0	Publications
42	BAX	BCL2-associated X protein	11.0	Publications
43	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	11.0	Publications
44	STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	11.0	Publications
45	PTK2	PTK2 protein tyrosine kinase 2	11.0	Publications
46	FHIT	fragile histidine triad	11.0	Publications
47	SKP2	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase	11.0	Publications
48	DCN	decorin	11.0	Publications
49	SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	11.0	Publications
50	MTA1	metastasis associated 1	11.0	Publications

Pathways related to laryngitis according to GeneDecks:

(show top 50)    (show all 242)

id	Pathway	Score	Top Affiliating Genes
1	Molecular Mechanisms of Cancer36	14.7	RB1, BRCA1, VEGFC, MYC, BMP6, RARB
2	Focal adhesion20	13.4	PIK3CA, VEGFC, RAF1, KDR, BCL2, BAD
3	Transendothelial Migration of Leukocytes36	12.7	CLDN7, CFL1, ITGA8, ITGAV, ITGB1, ITGB8
4	Endometrial cancer20	12.2	PIK3CA, MYC, RAF1, CDH1, MLH1, ILK
5	Development_EGFR signaling pathway41	12.2	PIK3CA, MYC, RAF1, JUN, MMP2, MMP9
6	Development_VEGF signaling via VEGFR2 - generic cascades41	12.2	PIK3CA, RELA, VEGFA, RAF1, JUN, ITGAV
7	Transcription_P53 signaling pathway41	12.1	RELA, RB1, VEGFA, KDR, BCL2, ATM
8	ErbB signaling pathway20	12.1	PIK3CA, MYC, RAF1, BAD, JUN, CDKN1A
9	IL-6 Pathway36	11.9	PIM1, BMP6, RAF1, BAX, IL10, IL18
10	DNA damage_ATM/ATR regulation of G1/S checkpoint41	11.7	RELA, PCNA, BRCA1, MYC, CHEK2, ATM
11	G1-S Phase Transition36	11.7	RB1, ATM, CDKN1A, CDK2, CDKN2B, CDKN1B
12	Cyclins and Cell Cycle Regulation36	11.7	RB1, RAF1, ATM, CDKN1A, CDK2, CDKN2B
13	Development_VEGF-family signaling41	11.6	PIK3CA, VEGFA, VEGFC, RAF1, KDR, ITGAV
14	Development VEGF-family signaling10	11.6	PIK3CA, VEGFC, RAF1, KDR, ITGAV, ITGB1
15	Development_HGF signaling pathway41	11.5	PIK3CA, RAF1, JUN, CDH1, MET, FAS
16	Rac1 Pathway36	11.5	BMP6, RAF1, KDR, CFL1, JUN, ITGA8
17	Colorectal cancer20	11.4	BAD, MSH2, MAP2K1, CASP9, TGFB1, TGFB2
18	Glioma20	11.4	PIK3CA, RB1, RAF1, CDKN1A, CDKN2A, CDK4
19	Transcription P53 signaling pathway10	11.3	RELA, VEGFA, CDK2, CDKN2A, MAP2K4, TP53
20	TGF-Beta Pathway36	11.3	VEGFC, BMP6, KDR, BCL2, BAX, JUN
21	p53 signaling pathway20	11.3	SFN, SERPINB5, SERPINE1, CHEK2, BAX, ATM
22	Apoptosis Signaling Pathways37	11.2	SFN, BIRC5, BIRC7, BCL2, BCL2L1, BAD
23	Apoptosis and survival Role of CDK5 in neuronal death and survival10	11.1	BCL2, BAD, APAF1, CASP9, ERBB3, CYCS
24	Regulation of eIF4 and p70S6K36	11.1	VEGFC, BAX, CD4, ITGA8, ITGB1, ITGB8
25	Tec Kinases Signaling36	10.8	VEGFC, BMP6, BCL2, BAX, CD4, ITGA8
26	MAPK Family Pathway36	10.8	VEGFC, BMP6, RAF1, KDR, BCL2, BAX
27	Rap1 Pathway36	10.8	VEGFC, BMP6, RAF1, ZAP70, ITGA8, ITGAV
28	Apoptosis20	10.0	PIK3CA, RELA, BCL2, BCL2L1, BAD, BAX
29	Tuberculosis20	9.9	RELA, RAF1, BCL10, BCL2, BAD, BAX
30	NF-KappaB (p50-p65) Pathway36	9.8	RELA, VEGFC, BMP6, KDR, FLT1, FLT4
31	MIF Regulation of Innate Immune Cells36	9.7	BMP6, BCL2, BAX, JUN, IL10, IL13
32	MIF Mediated Glucocorticoid Regulation36	9.6	BMP6, BCL2, BAX, IL10, IL13, IL18
33	Toll-like receptor signaling pathway20	9.4	PIK3CA, RELA, JUN, IL1B, IL6, IL8
34	JAK-STAT Pathway36	INF	, BRCA1, VEGFC, MYC, BMP6, RAF1
35	Renin-Angiotensin Pathway36	INF	, VEGFC, BMP6, RAF1, KDR, JUN
36	eIF2 Pathway36	INF	, VEGFC, BMP6, RAF1, FLT4, AREG
37	Estrogen Pathway36	INF	, BRCA1, VEGFC, BMP6, RAF1, KDR
38	Phospholipase-C Pathway36	INF	, VEGFC, BMP6, RAF1, KDR, ZAP70
39	eNOS Signaling36	INF	, BMP6, FLT4, AREG, MET, IL2
40	Mitochondrial Apoptosis36	INF	, VEGFC, BMP6, KDR, BCL2, BCL2L1
41	Cytokine-cytokine receptor interaction20	INF	, VEGFA, VEGFC, CLCF1, KDR, CD40LG
42	Nuclear Receptor Activation by Vitamin-A36	INF	, VEGFC, BMP6, RARB, KDR, FLT1
43	Endothelin-1 Signaling Pathway36	INF	, MYC, BMP6, RAF1, FLT1, FLT4
44	Pancreatic cancer20	INF	, AKT2
45	Nanog in Mammalian ESC Pluripotency36	INF	, VEGFC, BMP6, RAF1, KDR, FLT1
46	Pathways in cancer20	INF	PIK3CA, RELA, RB1, , VEGFA, VEGFC
47	Telomerase Components in Cell Signaling36	INF	, RB1, VEGFC, MYC, BMP6, KDR
48	Cell Cycle / Checkpoint Control3	INF	RECQL4, PCNA, RB1, BRCA1, , CHFR
49	ERK Signaling36	INF	, VEGFC, MYC, BMP6, RAF1, ZAP70
50	DHA Signaling36	INF	, VEGFC, BMP6, KDR, BCL2, BCL2L1

Compounds related to laryngitis according to GeneDecks:

(show top 50)    (show all 454)

id	Compound	Score	Top Affiliating Genes
1	butyrate32	15.2	PCNA, RB1, SETD2, VIM, MYC, BMP6
2	wortmannin32 42	15.5	PIK3CA, SETD2, VIM, RAF1, BIRC5, KDR
3	12-o-tetradecanoylphorbol 13-acetate32	14.3	RB1, SERPINB2, MYC, BMP6, RARB, RAF1
4	thymidylate32	13.9	PCNA, RB1, VIM, BRCA1, VEGFA, BIRC5
5	mg 13232 42	14.4	PCNA, BRCA1, MYC, MYCN, BLZF1, BIRC5
6	gf 109203x32 42	14.3	VEGFA, RAF1, JUN, CDKN1A, CDKN3, IVL
7	n acetylcysteine32	13.2	PCNA, SETD2, RAF1, BIRC5, CLU, KDR
8	okadaic acid32 42	14.0	PIK3CA, RELA, RB1, SERPINB2, VIM, MYC
9	betacarotene32	12.8	PCNA, RB1, RBP1, SERPINA3, NAT2, RARB
10	lactacystin32	12.7	BRCA1, MYC, MYCN, RAF1, BIRC5, BCL2
11	sialic acid32	12.0	SERPINA6, SERPINA3, CLU, LGALS1, MUC2, MUC5AC
12	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	11.9	PCNA, MYC, BCL2, BCL2L1, BAK1, BAX
13	mannitol32 9 9	13.9	CHKB, SARDH, S100B, XDH, CD40LG, CDKN3
14	cyclic amp32 18	12.8	RB1, SETD2, SERPINB2, RARB, BAD, LBR
15	vinblastine32 9 9	13.5	VIM, RAF1, BIRC5, KDR, BCL2, BCL2L1
16	chloramphenicol32 9 9	13.5	SETD2, SERPINE1, VIM, MYC, MYCN, RARB
17	egcg32	11.5	RAF1, BCL2L1, XIAP, CDK2, IVL, IL1A
18	acetylcholine32 9 18 9	14.5	SERPINA3, VIM, BMP6, RAF1, BLZF1, LBR
19	staurosporin32	11.4	PIK3CA, BCL2, BCL2L1, JUN, CDKN3, IL8
20	ionomycin32	11.4	PIM1, SETD2, SERPINA3, BCL10, CDK4, ANXA1
21	retinoid32	11.3	RBP1, VIM, MYC, MYCN, BMP6, RARB
22	malondialdehyde32	11.2	CHKB, LBR, XDH, MPO, GSR, GSTM1
23	carbachol32 9 9	13.1	LBR, HSPG2, CTSB, TAC1, KNG1
24	melphalan32 9 9	13.1	BIRC5, BCL2L1, CHKB, MUC16, XRCC3, CD79A
25	dmso32	11.1	VIM, BMP6, MUC5AC, XDH, CGB5, CD36
26	rotenone32	11.0	PARK7, BCL2, BCL2L1, BAD, XDH, GSR
27	1,25 dihydroxy vitamin d332	10.9	RB1, MYC, BMP6, RAF1, CLU, CDKN1B
28	l-nmma32	10.5	XDH, CGB5, CAT, NOS2, EDN1, EGR1
29	anisomycin32 42 9 9	13.4	MYC, RAF1, CFLAR, ATF3, JUN, IL1B
30	alpha tocopherol32	10.1	RARB, CHKB, MTHFR, XRCC1, XDH, CD36
31	topotecan32 9 9	12.1	SETD2, BRCA1, BIRC5, BCL2, BCL2L1, MUC16
32	triptolide32	10.0	VEGFA, BCL2, BAX, JUN, MMP3, IL1B
33	thyroxine32 18	10.8	PCNA, SERPINA6, SERPINA3, CHKB, CD79A, CD40LG
34	pentoxifylline32 9 9	11.4	BMP6, LBR, MPO, MMP1, MMP2, IL10
35	imatinib32 34 9 9	INF	PIK3CA, , VEGFA, MYC, BMP6, RAF1
36	folate32	INF	SERPINA3, VIM, NAT1, NAT2, BRCA1,
37	gp 13032	INF	PIM1, , BMP6, CLCF1, BCL2L1, CDC25C
38	agarose32	INF	, BRCA1, MYC, MYCN, BLZF1, CLU
39	arachidonic acid32 9 18 9	INF	PIK3CA, VIM, BCL2L1, LBR, S100A8, CD4
40	chloroquine32 34 9 9	INF	, BRCA1, BMP6, RAF1, CD79A, CD4
41	trastuzumab32 34 9 9	INF	PIK3CA, , VEGFC, RAF1, BIRC5, KDR
42	phosphotyrosine32	INF	PIK3CA, , KIR3DL1, BRCA1, RAF1, BLZF1
43	formaldehyde32 18	INF	, PCNA, RB1, VIM, BLZF1, LGALS3
44	hematoxylin32	INF	, PCNA, VIM, LGALS3, MUC1, MUC16
45	tamoxifen32 34 9 9	INF	PIK3CA, PCNA, SERPINB5, SERPINA6, VIM, BRCA1
46	adpribose32	INF	PIK3CA, PCNA, RB1, BRCA1, , BIRC5
47	genistein32 9 18 9	INF	PIK3CA, PCNA, RB1, SETD2, SERPINE1, VIM
48	valine32	INF	, SERPINA3, VIM, RAF1, MTHFR, MTR
49	estrogen32	INF	PCNA, BTG2, RBP1, SETD2, SERPINB5, SERPINA6
50	vincristine32 34 9 9	INF	, MYCN, CGB5, MGMT, FGF2, MAP2K4

Cellular components related to laryngitis according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	INF	PIM1, SH3GL2, , KIR3DL1, PCDH17, SERPINB2
2	nucleus	GO:005634	INF	PIM1, PDCD4, RECQL4, RELA, , KIF14
3	cytosol	GO:005829	16.6	PIK3CA, SH3GL2, PDCD4, RELA, VIM, NAT1
4	proteinaceous extracellular matrix	GO:005578	12.0	VEGFA, VCAN, LGALS1, LGALS3, MUC4, MMP1
5	extracellular region	GO:005576	11.7	SERPIND1, SERPINB2, SERPINE1, SERPINA3, VEGFA, VEGFC
6	cell surface	GO:009986	11.4	VEGFA, LGALS1, CD36, CD1D, CD44, CDH1
7	Golgi lumen	GO:005796	10.9	VCAN, BLZF1, MUC1, MUC12, MUC13, MUC15
8	platelet alpha granule lumen	GO:031093	10.2	SERPINE1, VEGFA, VEGFC, CLU, FN1, IGF1
9	cytoplasm	GO:005737	INF	PIM1, SH3GL2, PDCD4, RECQL4, RELA,
10	extracellular space	GO:005615	INF	, SFN, BTD, SERPINB5, SERPINB2, SERPINE1
11	nucleoplasm	GO:005654	INF	RELA, PCNA, RB1, BRCA1, , BNIP3
12	perinuclear region of cytoplasm	GO:048471	INF	CLU, BCL10, BAG1, XRCC3, S100A4, S100B
13	external side of plasma membrane	GO:009897	INF	, KDR, MUC17, CD79A, CD36, CD4

Biological processes related to laryngitis according to GeneDecks:

(show top 50)    (show all 57)

id	Name	GO ID	Score	Top Affiliating Genes
1	response to drug	GO:042493	13.8	VEGFC, MYC, PARK7, BCL2, LGALS1, BAG1
2	apoptotic process	GO:006915	13.4	PIM1, PDCD4, SFN, VIM, BRCA1, BRMS1
3	small molecule metabolic process	GO:044281	12.7	PIK3CA, BSG, NAT1, NAT2, VCAN, SDHC
4	cell proliferation	GO:008283	12.7	PIM1, SFN, PCNA, RAF1, ZMYND11, BLZF1
5	virus-host interaction	GO:019048	12.6	RELA, RB1, VIM, BNIP3, ZMYND11, KDR
6	G1/S transition of mitotic cell cycle	GO:000082	12.4	PCNA, RB1, BCL2, CDKN1A, CDK2, CDKN1B
7	innate immune response	GO:045087	12.4	RELA, CLU, BCL10, BCL2, BCL2L1, LGALS3
8	induction of apoptosis by intracellular signals	GO:008629	12.3	BNIP3, MYC, BMF, CLU, BCL2, BCL2L1
9	positive regulation of cell migration	GO:030335	12.2	VEGFA, KDR, ITGAV, ITGB1, MMP14, FLT1
10	blood coagulation	GO:007596	12.2	PIK3CA, SERPIND1, SERPINB2, SERPINE1, BSG, VEGFA
11	response to organic cyclic compound	GO:014070	12.2	BTG2, BAK1, MSH2, JUN, CDKN1A, MET
12	extracellular matrix disassembly	GO:022617	12.0	MMP1, MMP11, MMP13, MMP14, MMP16, MMP2
13	cell cycle arrest	GO:007050	11.9	RB1, MYC, RASSF1, MSH2, ATM, CDKN1A
14	angiogenesis	GO:001525	11.9	PIK3CA, SETD2, SERPINE1, VEGFA, VEGFC, KDR
15	response to ethanol	GO:045471	11.7	BCL2, BAK1, S100A8, MMP9, MGMT, IL13
16	negative regulation of apoptotic process	GO:043066	11.7	PIM1, RELA, BTG2, SERPINE1, VEGFA, MYC
17	release of cytochrome c from mitochondria	GO:001836	11.7	SFN, MYC, CLU, BCL2, BCL2L1, BAK1
18	response to lipopolysaccharide	GO:032496	11.7	S100A8, JUN, MMP9, MGST1, IL13, IL1A
19	regulation of cyclin-dependent protein kinase activity	GO:000079	11.7	SFN, CDKN1A, CDKN2B, CDKN1B, CDC25C, CDKN1C
20	cellular response to mechanical stimulus	GO:071260	11.6	BNIP3, BCL10, BAD, BAK1, ITGB1, IL13
21	activation of pro-apoptotic gene products	GO:008633	11.5	MYC, BMF, BCL2, BAD, BAK1, BAX
22	neuron apoptotic process	GO:051402	11.5	RB1, BNIP3, BCL2, BAX, ATM, FAS
23	extracellular matrix organization	GO:030198	11.4	SERPINB5, LGALS3, ITGA8, MMP1, MMP11, MMP13
24	positive regulation of epithelial cell proliferation	GO:050679	11.2	VEGFC, MYC, BMP6, BAD, GRN, IGF1
25	apoptotic DNA fragmentation	GO:006309	11.2	BNIP3, MYC, BIRC7, BAX, CDKN2A, ENDOG
26	organ regeneration	GO:031100	11.1	BAK1, CDKN1A, MKI67, ANGPT2, ANGPT1, CCNE1
27	positive regulation of angiogenesis	GO:045766	10.8	SERPINE1, VEGFA, KDR, MMP9, FLT1, FGF2
28	response to hypoxia	GO:001666	10.7	VEGFA, BNIP3, RAF1, BCL2, XRCC1, ATM
29	anti-apoptosis	GO:006916	10.6	PIK3CA, RELA, SERPINB2, BNIP3, BIRC5, BIRC7
30	platelet degranulation	GO:002576	10.6	SERPINE1, VEGFA, VEGFC, CLU, CFL1, CD36
31	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	10.5	MYC, BAD, BAX, XDH, CDKN1B, CDKN2A
32	platelet activation	GO:030168	10.4	PIK3CA, SERPINE1, VEGFA, VEGFC, RAF1, CLU
33	O-glycan processing	GO:016266	10.4	MUC1, MUC12, MUC13, MUC15, MUC16, MUC17
34	positive regulation of apoptotic process	GO:043065	10.4	RARB, CLU, BAD, BAK1, BAX, ATM
35	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.2	RELA, BCL10, LGALS1, S100A4, S100B, CFLAR
36	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.2	KDR, CD44, FLT4, FGF2, IL1A, IL1B
37	positive regulation of nitric oxide biosynthetic process	GO:045429	10.2	IL1B, IFNG, ICAM1, HSP90AB1, AKT1, ESR1
38	cell-cell signaling	GO:007267	10.1	IL10, IL13, IL18, IL1B, IL2, FASLG
39	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.9	RELA, RB1, SERPINE1, BRCA1, VEGFA, MYC
40	positive regulation of mitosis	GO:045840	8.8	AURKA, MET, IL1A, IL1B, IGF2, IGF1
41	positive regulation of cell proliferation	GO:008284	INF	, VEGFA, VEGFC, MYC, BIRC5, CLCF1
42	response to estradiol stimulus	GO:032355	INF	, AURKA, MMP9, IL1B, ENO2, ANXA1
43	activation of MAPK activity	GO:000187	INF	, MUC20, FGF2, MET, IL1B, MAPK3
44	negative regulation of cell proliferation	GO:008285	INF	SFN, BTG2, RARB, RAF1, BAK1, ATP8A2
45	response to radiation	GO:009314	INF	, BCL2, JUN, CDC25A, MMP9, IL18
46	positive regulation of transcription, DNA-dependent	GO:045893	INF	RELA, RB1, BRCA1, , MYC, BCL10
47	inflammatory response	GO:006954	INF	RELA, , SERPINA3, BMP6, PARK7, S100A8
48	signal transduction	GO:007165	INF	SH3GL2, , SFN, VEGFC, RARB, RAF1
49	induction of apoptosis	GO:006917	INF	BNIP3, BCL10, BAD, BAX, CDKN1B, CDKN2A
50	response to gamma radiation	GO:010332	INF	, MYC, BCL2, CHEK2, BAK1, BAX

Molecular functions related to laryngitis according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	TIMP3, , PRX, OGG1, CXCR4, SOCS1
2	protein homodimerization activity	GO:042803	INF	CRP, SP100, PTGS2, TERT, TERF1, ERCC5
3	protein heterodimerization activity	GO:046982	12.2	EGFR, RXRA, TERF1, TP53, ERBB2, HIF1A
4	identical protein binding	GO:042802	12.2	RELA, PCNA, VIM, BNIP3, RAF1, RASSF1
5	enzyme binding	GO:019899	11.5	BRCA1, BLZF1, BIRC5, BIRC7, BCL10, MSH2
6	receptor binding	GO:005102	10.1	NOS2, PTPRD, TNFSF9, TNFSF10, TNC, TGFB2
7	growth factor activity	GO:008083	9.6	CTGF, EGF, TYMP, TGFA, TGFB1, TGFB2
8	cytokine activity	GO:005125	9.4	TNF, HMGB1, IFNG, IFNA2, FASLG, TNFSF10
9	protein kinase binding	GO:019901	INF	CCND3, STAT3, SOCS1, MYH6, HIF1A, ELAVL1