MCID: LRY019
MIFTS: 62

Laryngitis malady

Summaries for Laryngitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

MalaCards: Laryngitis, also known as laryngitis nos, is related to laryngeal squamous cell carcinoma and squamous cell carcinoma. An important gene associated with Laryngitis is ICK (intestinal cell (MAK-like) kinase), and among its related pathways are Validated targets of C-MYC transcriptional activation and Integrated Pancreatic Cancer Pathway. The drug guaifenesin and the compounds progesterone and vegf have been mentioned in the context of this disorder. Affiliated tissues include lymph node, endothelial and thyroid, and related mouse phenotypes are mortality/aging and cellular.

Wikipedia:63 Laryngitis is an inflammation of the larynx. It causes hoarse voice or temporary complete loss of the... more...

Aliases & Classifications for Laryngitis

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

laryngitis 8 10 60
laryngitis nos 8


External Ids:

Disease Ontology8 DOID:3437
NCIt39 C26811
SNOMED-CT56 45913009
MeSH34 D007827

Related Diseases for Laryngitis

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17GeneCards, 18GeneDecks
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Diseases in the Laryngitis family:

Viral Laryngitis Chronic Laryngitis
Acute Laryngitis

Diseases related to Laryngitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 506)
idRelated DiseaseScoreTop Affiliating Genes
1laryngeal squamous cell carcinoma31.7GSTT1, GSTM1, TP53, TERT, BIRC5, NME1
2squamous cell carcinoma31.7NME1, EIF4E, MKI67, CCND1
3papilloma30.7TP53, PCNA, IFI27
4rhabdomyosarcoma30.3TP53, MMP14, EIF4E
5chondrosarcoma30.3MMP14
6adenoma30.2GSTT1, GSTM1, TP53, TERT, BIRC5, NME1
7sarcoma30.2GSTM1, TP53, TERT, MKI67
8papillary carcinoma30.2NME1, MKI67, VEGFC, IFI27
9adenoid cystic carcinoma30.1PCNA, MKI67, CCND1
10adenocarcinoma30.1GSTT1, GSTM1, TP53, TERT, BIRC5, NME1
11cervical squamous cell carcinoma30.1MMP14, MKI67
12papillary thyroid carcinoma30.1VEGFC, IFI27, CCND1
13leiomyosarcoma30.1TP53
14laryngeal benign neoplasm30.0GSTT1, GSTM1, TERT, NME1, MMP14, NAT2
15lung cancer29.9GSTM1, TP53, TERT, BIRC5, NME1, MMP14
16retinoblastoma29.9TP53, TERT, BIRC5, NME1, PCNA, MKI67
17breast cancer29.9CTSD, AURKA, IFI27, CCND1
18colon adenocarcinoma29.9EIF4E
19herpes simplex29.9CTSD
20parathyroid adenoma29.9CCND1
21asthma29.8GSTT1, GSTM1, MMP14, NAT2
22leiomyoma29.8PCNA, MKI67, BSG
23arthritis29.8MMP14
24hepatoblastoma29.8BIRC5
25melanoma29.6GSTT1, TP53, TERT, BIRC5, NME1, MMP14
26cervical cancer29.6GSTT1, GSTM1, TP53, TERT, BIRC5, NME1
27leukemia29.6GSTT1, GSTM1, TP53, TERT, BIRC5, NME1
28lung adenocarcinoma29.6GSTT1, GSTM1, TP53, TERT, BIRC5, MMP14
29thyroid cancer29.6TERT, NME1, MMP14, VEGFC, CTSD, IFI27
30lung small cell carcinoma29.6GSTT1, GSTM1, TP53, VEGFC, CTSD
31non-hodgkin lymphoma29.6GSTT1, GSTM1, BIRC5, NAT2, CCND1
32smooth muscle tumor29.6NME1, PCNA, MKI67, IFI27
33acute leukemia29.6GSTT1, GSTM1, TERT, BIRC5
34pancreatic cancer29.6TERT, BIRC5, MMP14, CCND1
35gastrointestinal stromal tumor29.6PCNA, MKI67, IFI27
36ischemia29.6MMP14, VEGFC, BSG, CTSD
37inverted papilloma29.6PCNA, MKI67, IFI27
38myeloid leukemia29.6BIRC5, NME1
39parathyroid carcinoma29.6MKI67, CCND1
40malignant mesothelioma29.6NAT2
41tongue cancer29.6TERT
42meningioma29.6PCNA, MKI67
43cleft palate29.6GSTM1
44measles29.6AURKA
45angiosarcoma29.6VEGFC
46laryngeal carcinoma11.3
47laryngeal tuberculosis10.8
48tuberculosis10.8
49laryngeal disease10.7
50chronic laryngitis10.7

Graphical network of the top 20 diseases related to Laryngitis:



Diseases related to laryngitis

Clinical Features for Laryngitis

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Drugs & Therapeutics for Laryngitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Laryngitis

Drug clinical trials:

Search ClinicalTrials for Laryngitis

Search NIH Clinical Center for Laryngitis

Search CenterWatch for Laryngitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Laryngitis

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Anatomical Context for Laryngitis

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32MalaCards
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MalaCards organs/tissues related to Laryngitis:

32
Lymph node, Endothelial, Thyroid, Lung, Skin, Colon, Testes, Tongue, Heart, Bone, Trachea, Breast, T cells, Tonsil, Prostate, Pituitary, Appendix, Eye, Fetal lung, Brain, Smooth muscle, Small intestine, Monocytes, Myeloid, Liver, Bone marrow

Animal Models for Laryngitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Laryngitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076812.2TP53, CCND1, AURKA, CTSD, BSG, VEGFC
2MP:000538411.9CCND1, AURKA, CTSD, PCNA, EIF4E, MMP14
3MP:000537811.8BSG, CTSD, AURKA, CCND1, MID1, PCNA
4MP:000538711.4CCND1, CTSD, BSG, VEGFC, PCNA, MMP14
5MP:000537911.1TP53, TERT, NME1, CTSD, CCND1
6MP:000537611.1CTSD, NAT2, MMP14, GSTT1
7MP:000200611.0CCND1, AURKA, EIF4E, NME1, TERT

Publications for Laryngitis

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50PubMed
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Articles related to Laryngitis:

(show top 50)    (show all 2868)
idTitleAuthorsYear
1
Well and intermediate differentiated laryngeal chondrosarcoma: toward conservative surgery? (23974330)
2014
2
MiR-19a is correlated with prognosis and apoptosis of laryngeal squamous cell carcinoma by regulating TIMP-2 expression. (24427326)
2013
3
Clinical features of laryngeal tuberculosis in iran. (24338196)
2013
4
Primary laryngeal actinomycosis in an immunosuppressed woman: a case report. (23904305)
2013
5
Inhibition of p21-activated kinaseA 4 expression suppresses the proliferation of Hep-2 laryngeal carcinoma cells via activation of the ATM/Chk1/2/p53 pathway. (23229348)
2013
6
Identification of the PAG1 gene as a novel target of inherent radioresistance in human laryngeal carcinoma cells. (22994656)
2012
7
Effects of conjugated linoleic acid and high oleic acid safflower oil in the treatment of children with HPV-induced laryngeal papillomatosis: a randomized, double-blinded and crossover preliminary study. (23061633)
2012
8
Laryngeal reinnervation after vagal paraganglioma resection: a case report. (20392529)
2011
9
Voice handicap index and voice-related quality of life in small laryngeal carcinoma. (20821335)
2011
10
Effects of HIV-1 Nef on virus co-receptor expression and cytokine release in human bladder, laryngeal, and intestinal epithelial cell lines. (21668366)
2011
11
Expression of programmed cell death 4 protein is closely correlated with laryngeal squamous cell carcinomas]. (21949999)
2011
12
Nutlin-3, the small-molecule inhibitor of MDM2, promotes senescence and radiosensitises laryngeal carcinoma cells harbouring wild-type p53. (20588277)
2010
13
A rare benign laryngeal tumor: angiomyolipoma. (21119467)
2010
14
The expression of DNMT1 in laryngeal squamous cell carcinoma and its clinical significance]. (21395176)
2010
15
Tuberculous cervical lymphadenitis in a patient with laryngeal carcinoma. (19646297)
2010
16
Prognostic significance of fascin-1 and E-cadherin expression in laryngeal squamous cell carcinoma. (19741544)
2010
17
CD105 expression as a measure of microvessel density in supraglottic laryngeal squamous cell carcinoma. (19340447)
2009
18
HPV-induced recurrent laryngeal papillomatosis: rationale for adjuvant fatty acid therapy. (18586635)
2008
19
Laryngeal granular cell tumor. (17134875)
2008
20
Soluble EMMPRIN (extra-cellular matrix metalloproteinase inducer) stimulates the migration of HEp-2 human laryngeal carcinoma cells, accompanied by increased MMP-2 production in fibroblasts. (18431027)
2007
21
The expression of tumor necrosis factor related apoptosis induce ligand in human laryngeal squamous cell carcinoma]. (17357513)
2006
22
The relationship between hypermethylation of the PTEN promoter and laryngeal squamous cell carcinoma]. (16739377)
2006
23
Laryngeal tuberculosis presenting as supraglottic carcinoma: case report and literature review. (16910293)
2006
24
Fetoscopic and ultrasound-guided decompression of the fetal trachea in a human fetus with Fraser syndrome and congenital high airway obstruction syndrome (CHAOS) from laryngeal atresia. (16308883)
2006
25
Treatment of chronic posterior laryngitis with esomeprazole. (16955013)
2006
26
Prognostic significance of Jab1 expression in laryngeal squamous cell carcinomas. (15671554)
2005
27
Malignant granular cell tumor in larynx mimicking laryngeal carcinoma. (15239036)
2004
28
The expression of VEGF and iNOS in laryngeal squamous cell carcinoma and its clinical significance]. (15831042)
2004
29
Effect of acid and pepsin on gene expression in laryngeal fibroblasts. (15562895)
2004
30
Pharyngeal--laryngeal blastomycosis in a dog. (14705432)
2003
31
Spirometric and plethysmographic assessment of upper airway obstruction in laryngeal hemiplegia. (14703103)
2003
32
Curative radiotherapy for anterior commissure laryngeal carcinoma. (10685566)
2000
33
C-erbB-2 immunostaining in laryngeal cancer. (10380748)
1999
34
Molecular analysis of resistance to interferon in patients with laryngeal papillomatosis. (10515680)
1999
35
Estrogen metabolism and laryngeal papillomatosis: a pilot study on dietary prevention. (9891520)
1998
36
Laryngeal chondroma. (23119313)
1997
37
Prognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma. (8883413)
1996
38
Laryngeal tuberculosis: CT findings. (8553964)
1996
39
Late recurrences of laryngeal papillomatosis. (8797557)
1996
40
The prevalence of different human papillomavirus types and p53 mutations in laryngeal carcinomas: is there a reciprocal relationship? (7781800)
1995
41
Secondary syphilis presenting as cutaneous nodules in a patient previously treated for laryngeal carcinoma. (1733660)
1992
42
Laryngeal tuberculosis in the eighties--an Indian experience. (2584878)
1989
43
Laryngeal botryoid rhabdomyosarcoma in an adult. Report of a case with electron microscopic study. (2780434)
1989
44
Tracheal involvement in laryngeal papillomatosis. (6296564)
1983
45
Laser surgery in benign laryngeal disease. (7180425)
1982
46
Benign mucous membrane pemphigoid with laryngeal stenosis in a patient with thyroid carcinoma. (5654579)
1968
47
Juvenile laryngeal papillomatosis. The relation of radiation to malignant degeneration in this disease. (5296305)
1965
48
Ultrasound for juvenile laryngeal papillomatosis. A preliminary report of five cases. (13968416)
1963
49
Laryngocele of the laryngeal pouch]. (12977724)
1952
50
Case of Aneurism of the Thoracic Aorta: Bursting into the Trachea, Simulating Chronic Laryngitis. (20795146)
1852

Genetic Variations for Laryngitis

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Expression for genes affiliated with Laryngitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Laryngitis

Search GEO for disease gene expression data for Laryngitis.

Pathways for genes affiliated with Laryngitis

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37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 4Cell Signaling Technology, 51QIAGEN, 49PharmGKB, 53Reactome
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Compounds for genes affiliated with Laryngitis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Laryngitis according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2416.6TP53, CCND1, CTSD, BIRC5, NME1, MMP14
2vegf4412.6IFI27, TERT, TP53, CCND1, CTSD, BSG
3cisplatin44 49 59 1115.5CCND1, IFI27, CTSD, PCNA, EIF4E, BIRC5
4oligonucleotide4412.5IFI27, BIRC5, CCND1, NME1, GSTT1, TERT
5paraffin4412.4CTSD, VEGFC, PCNA, NME1, MKI67, MMP14
6thymidine44 2413.4TP53, MKI67, CTSD, VEGFC, CCND1, MMP14
7retinoic acid44 2413.3PCNA, TP53, VEGFC, IFI27, CCND1, EIF4E
8oxygen44 2413.2CTSD, MMP14, EIF4E, IFI27, TERT, GSTT1
9ly2940024412.1BIRC5, TP53, IFI27, BSG, VEGFC, EIF4E
10doxorubicin44 49 1114.1IFI27, CTSD, TP53, MKI67, CCND1, GSTT1
11lactate4412.1MMP14, GSTM1, PCNA, NME1, MKI67, BIRC5
12testosterone44 59 11 2415.1TERT, CTSD, GSTM1, BIRC5, PCNA, MKI67
13threonine4412.0BIRC5, MMP14, CCND1, AURKA, BSG, MKI67
14p0024412.0MKI67, MMP14, NME1, BIRC5, GSTM1, IFI27
15thymidylate4412.0GSTM1, IFI27, PCNA, BIRC5, TERT, TP53
165fluorouracil4411.9NME1, BIRC5, TP53, TERT, PCNA, GSTM1
17paclitaxel44 49 1113.8TERT, CCND1, IFI27, AURKA, CTSD, BIRC5
18n acetylcysteine4411.8CCND1, IFI27, EIF4E, BIRC5, TERT, PCNA
19pd 98,0594411.7IFI27, CCND1, VEGFC, EIF4E, MMP14, BIRC5
20steroid4411.7NME1, EIF4E, MKI67, CTSD, BIRC5, IFI27
21adpribose4411.7TERT, TP53, PCNA, BIRC5, IFI27, CCND1
22genistein44 28 59 2 11 2416.7BIRC5, MMP14, IFI27, CCND1, CTSD, PCNA
23mg 13244 5912.6PCNA, TP53, EIF4E, CCND1, BIRC5, IFI27
24cyclophosphamide44 49 1113.6GSTT1, MKI67, GSTM1, CTSD, TP53, PCNA
25serine4411.6NME1, MMP14, EIF4E, MKI67, AURKA, CCND1
26arsenite44 2412.6CCND1, PCNA, EIF4E, TERT, BIRC5, TP53
27norcantharidin4411.6CCND1, BIRC5, PCNA, MKI67, IFI27
28chi 24411.6IFI27, MKI67, NME1, GSTM1, GSTT1
29p000014411.5BIRC5, MMP14, MKI67, VEGFC, CCND1
30phosphatidylinositol4411.5CCND1, TERT, MMP14, IFI27, CTSD, VEGFC
31dutp4411.5PCNA, TP53, CCND1, BIRC5, MKI67
32sulindac44 1112.5IFI27, CCND1, PCNA, BIRC5, TP53
33roscovitine4411.5TP53, CCND1, IFI27, PCNA, BIRC5
34methotrexate44 49 1113.5GSTM1, CCND1, MKI67, BIRC5, NAT2, PCNA
35trastuzumab44 49 1113.5CCND1, VEGFC, BIRC5, IFI27, CTSD
36agar4411.5CTSD, CCND1, BIRC5, EIF4E, MMP14, NME1
37tamoxifen44 49 28 1114.4MKI67, BIRC5, CCND1, CTSD
388-oxo-dg4411.3PCNA, TP53, GSTT1, GSTM1
39etoposide44 49 59 1114.3TERT, CTSD, EIF4E
40estradiol44 11 2413.3CTSD, BIRC5, VEGFC, MKI67
41p0034411.3IFI27, GSTM1, GSTT1, CTSD, MKI67
42aflatoxin b144 2412.3GSTM1, GSTT1, NAT2, TP53
43acetone4411.2GSTT1, CCND1, GSTM1, MKI67
44nitric oxide44 11 2413.2CTSD, BIRC5, EIF4E, NAT2, MKI67, VEGFC
45drugs for treatment of tuberculosis4911.2GSTT1, GSTM1, NAT2
46nimbolide4411.2CCND1, PCNA, BIRC5
47crcs4411.1BIRC5, TP53, NME1, CCND1
48indole-3-carbinol4411.0TP53, IFI27, BIRC5, CCND1
49vincristine44 49 1112.9MKI67, CCND1, GSTM1
50adriamycin4410.9CCND1, CTSD, BIRC5, TERT

GO Terms for genes affiliated with Laryngitis

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16Gene Ontology
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Cellular components related to Laryngitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582911.5GSTT1, CCND1, ICK, AURKA, NAT2, EIF4E
2melanosomeGO:04247010.9MMP14, BSG, CTSD

Biological processes related to Laryngitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:09039910.7TP53, TERT
2mitotic G1 DNA damage checkpointGO:03157110.4TP53, CCND1

Molecular functions related to Laryngitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.2TP53, CCND1, ICK, AURKA, CTSD, BSG
2protein kinase bindingGO:01990111.0TP53, NME1, AURKA, CCND1
3enzyme bindingGO:01989910.7CCND1, BIRC5, TP53, GSTM1

Products for genes affiliated with Laryngitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Laryngitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet