MCID: LRY019
MIFTS: 53

Laryngitis malady

Summaries for Laryngitis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Fully expand this MalaCard

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Disease Ontology:8 A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

MalaCards: Laryngitis, also known as laryngitis nos, is related to squamous cell carcinoma and leukoplakia. An important gene associated with Laryngitis is ICK (intestinal cell (MAK-like) kinase), and among its related pathways are Validated targets of C-MYC transcriptional activation and Integrated Pancreatic Cancer Pathway. The drug guaifenesin and the compounds progesterone and vegf have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and cellular.

Wikipedia:64 Laryngitis is an inflammation of the larynx. It causes hoarse voice or temporary complete loss of the... more...

Aliases & Classifications for Laryngitis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Aliases & Descriptions:

laryngitis 8 10 61
laryngitis nos 8


External Ids:

Disease Ontology8 DOID:3437
NCIt40 C26811
SNOMED-CT57 45913009
MeSH35 D007827

Related Diseases for Laryngitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Laryngitis family:

viral laryngitis chronic laryngitis
acute laryngitis

Diseases related to Laryngitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 514)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.7NME1, EIF4E, MKI67, CCND1
2leukoplakia30.3GSTT1, GSTM1, NME1, PCNA, MKI67, IFI27
3adenoma30.3GSTT1, GSTM1, TP53, TERT, BIRC5, NME1
4papillary carcinoma30.2NME1, MKI67, VEGFC, IFI27
5adenoid cystic carcinoma30.2PCNA, MKI67, CCND1
6adenocarcinoma30.2GSTT1, GSTM1, TP53, TERT, BIRC5, NME1
7basal cell carcinoma30.1GSTT1, GSTM1, TP53, MKI67
8oral cancer30.0GSTT1, GSTM1, TP53, TERT, BIRC5, PCNA
9oral leukoplakia29.8GSTM1, PCNA, MKI67, IFI27
10asthma29.8GSTT1, GSTM1, MMP14, NAT2
11arthritis29.8MMP14
12thyroid cancer29.6TERT, NME1, MMP14, VEGFC, CTSD, IFI27
13smooth muscle tumor29.6NME1, PCNA, MKI67, IFI27
14acute leukemia29.6GSTT1, GSTM1, TERT, BIRC5
15gastrointestinal stromal tumor29.6PCNA, MKI67, IFI27
16esophageal squamous cell carcinoma29.6GSTM1, IFI27, CCND1
17parathyroid carcinoma29.6MKI67, CCND1
18tongue cancer29.6TERT
19cleft palate29.6GSTM1
20measles29.6AURKA
21angiosarcoma29.6VEGFC
22laryngeal papillomatosis10.9
23tuberculosis10.8
24laryngeal tuberculosis10.8
25chronic laryngitis10.7
26acute laryngitis10.6
27laryngeal cleft10.6
28spasmodic dysphonia10.5
29anal squamous cell carcinoma10.5
30squamous cell papilloma10.4
31supraglottic laryngeal cancer10.4
32tracheal stenosis10.4
33laryngocele10.4
34laryngeal small cell carcinoma10.3
35amyloidosis10.3
36hypoxia10.3
37congenital laryngeal cyst10.3
38pulmonary tuberculosis10.3
39croup10.3
40angioedema10.3
41small cell carcinoma10.3
42gastroesophageal reflux disease10.3
43paraganglioma10.3
44treacher collins syndrome10.2
45hereditary angioedema10.2
46pharyngitis10.2
47epiglottitis10.2
48laryngeal adenoid cystic carcinoma10.2
49cicatricial pemphigoid10.2
50actinomycosis10.2

Graphical network of the top 20 diseases related to Laryngitis:



Diseases related to laryngitis

Clinical Features for Laryngitis

Drugs & Therapeutics for Laryngitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Laryngitis

Drug clinical trials:

Search ClinicalTrials for Laryngitis

Search NIH Clinical Center for Laryngitis

Search CenterWatch for Laryngitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Laryngitis

Anatomical Context for Laryngitis

Animal Models for Laryngitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Laryngitis

Sources:
51PubMed
See all sources

Articles related to Laryngitis:

(show top 50)    (show all 344)
idTitleAuthorsYear
1
Posterior laryngitis: a disease with different aetiologies affecting health-related quality of life: a prospective case-control study. (24015952)
2013
2
Predictors of acid suppression success in patients with chronic laryngitis. (22276941)
2012
3
Herpes zoster laryngitis and Ramsay-Hunt syndrome in a patient with chronic renal failure. (22338244)
2011
4
Classical reflux symptoms, hiatus hernia and overweight independently predict pharyngeal acid exposure in patients with suspected reflux laryngitis. (21083591)
2011
5
GERD-related chronic laryngitis: pro. (20855685)
2010
6
Dilated intercellular space in chronic laryngitis and gastro-oesophageal reflux disease: at baseline and post-lansoprazole therapy. (20735783)
2010
7
Gastroesophageal reflux-related chronic laryngitis: con. (20855684)
2010
8
Allergic laryngitis as a cause of dysphonia: a preliminary report. (20712433)
2010
9
Heterotopic gastric mucosal patch in patients with reflux laryngitis: an entity of clinical interest? (19851260)
2009
10
Heterotopic gastric mucosa in the cervical esophagus: could this play a role in the pathogenesis of laryngopharyngeal reflux in a subgroup of patients with posterior laryngitis? (16265772)
2005
11
Antibiotics for acute laryngitis in adults. (16035684)
2005
12
Improvement in clinical course and laryngeal appearance in selected patients with chronic laryngitis after eight weeks of therapy with rabeprazole. (15448612)
2004
13
Manifestations of gastroesophageal reflux and response to omeprazole therapy in patients with chronic posterior laryngitis: an evaluation based on clinical practice. (14705815)
2003
14
Ulcerative fungal laryngitis. (12696232)
2003
15
Lidocaine spray used to capture a live Clinostomum parasite causing human laryngitis. (13130449)
2003
16
Evaluation of omeprazole in the treatment of reflux laryngitis: a prospective, placebo-controlled, randomized, double-blind study. (11802014)
2001
17
Severe upper airway obstruction caused by ulcerative laryngitis. (11567944)
2001
18
Acute laryngitis. (10935296)
2000
19
Herpes simplex viral laryngitis. (10855577)
2000
20
Acute laryngitis. (11933444)
2000
21
Candida laryngitis appearing as leukoplakia and GERD. (9619984)
1998
22
Empiric trial of high-dose omeprazole in patients with posterior laryngitis: a prospective study. (9399745)
1997
23
A case of toxoplasmatic rhinitis and laryngitis. (8758322)
1996
24
Upper airway obstruction caused by group G streptococcal laryngitis. (7717474)
1995
25
Omeprazole for the treatment of posterior laryngitis. (7503099)
1995
26
Tuberculous laryngitis--a one year harvest. (4056598)
1985
27
Nonspecific pharyngitis and laryngitis. (6131218)
1983
28
The prevalence of tuberculous laryngitis in pulmonary tuberculosis in Tanzanians. (6981871)
1982
29
Tuberculous laryngitis in childhood. (6815292)
1982
30
Acid laryngitis. (5021719)
1972
31
Cortisone and phenylbutazone in the treatment of diphtheritic croup and non-diphtheritic stenosing laryngitis. (13751727)
1960
32
Treatment of pharyngitis and laryngitis with an improved hydrogen peroxide. (14399820)
1959
33
Laryngitis in children. (13409114)
1957
34
Acute obstructive laryngitis. (croup). (13262654)
1955
35
On the treatment of acute stenosing laryngitis in children. (13228002)
1954
36
The incidence, treatment and prognosis of tuberculous laryngitis in pulmonary tuberculosis. (20257959)
1947
37
Obstructive laryngitis in children caused by Hemophilus influenzae bacillus type B. (20287095)
1947
38
The treatment with antiserum of acute laryngitis caused by Hemophilus influenzae. (21007906)
1945
39
Tuberculous Laryngitis: An Analysis of 428 Cases. (20782932)
1940
40
Laryngitis:? Tuberculous. (19992056)
1939
41
Advanced Pulmonary Tuberculosis with Tuberculous Laryngitis, successfully treated by Thoracoplasty and Cauterization of Larynx. (19989945)
1934
42
Hyperplastic Laryngitis and Pharyngitis;A ? MyxA9dema (Shown a year ago, but not reported. (20911246)
1929
43
"Hyperplastic" Laryngitis (previously shown November 7, 1924). (19986445)
1928
44
Case of Laryngitis: for Diagnosis. (19985674)
1927
45
Case of Chronic Laryngitis of Long Standing. (19982948)
1923
46
Acute Phlegmonous Laryngitis, Streptococcus Septic Pneumonia. (20312320)
1920
47
Chronic Laryngitis in a Man aged 26.? Prolapse of Ventricle on Right Side. (19974415)
1910
48
Hypertrophic Laryngitis with Stenosis in a Syphilitic Subject. (19974459)
1910
49
The Treatment of Acute and of Chroniccatarrhal Laryngitis in Adults: With Some Remarks on the Use of the Laryngoscope. (20749583)
1880
50
The Indications for Tracheotomy in Cases of Laryngitis and Diphtheria. (20745733)
1870

Genetic Variations for Laryngitis

Expression for genes affiliated with Laryngitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Laryngitis

Search GEO for disease gene expression data for Laryngitis.

Pathways for genes affiliated with Laryngitis

Sources:
38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 4Cell Signaling Technology, 52QIAGEN, 50PharmGKB, 54Reactome
See all sources

Compounds for genes affiliated with Laryngitis

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Laryngitis according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1progesterone45 60 29 11 2416.6TP53, CCND1, CTSD, BIRC5, NME1, MMP14
2vegf4512.6IFI27, TERT, TP53, CCND1, CTSD, BSG
3cisplatin45 50 60 1115.5CCND1, IFI27, CTSD, PCNA, EIF4E, BIRC5
4oligonucleotide4512.5IFI27, BIRC5, CCND1, NME1, GSTT1, TERT
5paraffin4512.4CTSD, VEGFC, PCNA, NME1, MKI67, MMP14
6thymidine45 2413.4TP53, MKI67, CTSD, VEGFC, CCND1, MMP14
7retinoic acid45 2413.3PCNA, TP53, VEGFC, IFI27, CCND1, EIF4E
8oxygen45 2413.2CTSD, MMP14, EIF4E, IFI27, TERT, GSTT1
9ly2940024512.1BIRC5, TP53, IFI27, BSG, VEGFC, EIF4E
10doxorubicin45 50 1114.1IFI27, CTSD, TP53, MKI67, CCND1, GSTT1
11lactate4512.1MMP14, GSTM1, PCNA, NME1, MKI67, BIRC5
12testosterone45 60 11 2415.1TERT, CTSD, GSTM1, BIRC5, PCNA, MKI67
13threonine4512.0BIRC5, MMP14, CCND1, AURKA, BSG, MKI67
14p0024512.0MKI67, MMP14, NME1, BIRC5, GSTM1, IFI27
15thymidylate4512.0GSTM1, IFI27, PCNA, BIRC5, TERT, TP53
165fluorouracil4511.9NME1, BIRC5, TP53, TERT, PCNA, GSTM1
17paclitaxel45 50 1113.8TERT, CCND1, IFI27, AURKA, CTSD, BIRC5
18n acetylcysteine4511.8CCND1, IFI27, EIF4E, BIRC5, TERT, PCNA
19pd 98,0594511.7IFI27, CCND1, VEGFC, EIF4E, MMP14, BIRC5
20steroid4511.7NME1, EIF4E, MKI67, CTSD, BIRC5, IFI27
21adpribose4511.7TERT, TP53, PCNA, BIRC5, IFI27, CCND1
22genistein45 29 60 2 11 2416.7BIRC5, MMP14, IFI27, CCND1, CTSD, PCNA
23mg 13245 6012.6PCNA, TP53, EIF4E, CCND1, BIRC5, IFI27
24cyclophosphamide45 50 1113.6GSTT1, MKI67, GSTM1, CTSD, TP53, PCNA
25serine4511.6NME1, MMP14, EIF4E, MKI67, AURKA, CCND1
26arsenite45 2412.6CCND1, PCNA, EIF4E, TERT, BIRC5, TP53
27norcantharidin4511.6CCND1, BIRC5, PCNA, MKI67, IFI27
28chi 24511.6IFI27, MKI67, NME1, GSTM1, GSTT1
29p000014511.5BIRC5, MMP14, MKI67, VEGFC, CCND1
30phosphatidylinositol4511.5CCND1, TERT, MMP14, IFI27, CTSD, VEGFC
31dutp4511.5PCNA, TP53, CCND1, BIRC5, MKI67
32sulindac45 1112.5IFI27, CCND1, PCNA, BIRC5, TP53
33roscovitine4511.5TP53, CCND1, IFI27, PCNA, BIRC5
34methotrexate45 50 1113.5GSTM1, CCND1, MKI67, BIRC5, NAT2, PCNA
35trastuzumab45 50 1113.5CCND1, VEGFC, BIRC5, IFI27, CTSD
36agar4511.5CTSD, CCND1, BIRC5, EIF4E, MMP14, NME1
37tamoxifen45 50 29 1114.4MKI67, BIRC5, CCND1, CTSD
388-oxo-dg4511.3PCNA, TP53, GSTT1, GSTM1
39etoposide45 50 60 1114.3TERT, CTSD, EIF4E
40estradiol45 11 2413.3CTSD, BIRC5, VEGFC, MKI67
41p0034511.3IFI27, GSTM1, GSTT1, CTSD, MKI67
42aflatoxin b145 2412.3GSTM1, GSTT1, NAT2, TP53
43acetone4511.2GSTT1, CCND1, GSTM1, MKI67
44nitric oxide45 11 2413.2CTSD, BIRC5, EIF4E, NAT2, MKI67, VEGFC
45drugs for treatment of tuberculosis5011.2GSTT1, GSTM1, NAT2
46nimbolide4511.2CCND1, PCNA, BIRC5
47crcs4511.1BIRC5, TP53, NME1, CCND1
48indole-3-carbinol4511.0TP53, IFI27, BIRC5, CCND1
49vincristine45 50 1112.9MKI67, CCND1, GSTM1
50adriamycin4510.9CCND1, CTSD, BIRC5, TERT

GO Terms for genes affiliated with Laryngitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Laryngitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582911.5GSTT1, CCND1, ICK, AURKA, NAT2, EIF4E
2melanosomeGO:04247010.9MMP14, BSG, CTSD

Biological processes related to Laryngitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:09039910.7TP53, TERT
2mitotic G1 DNA damage checkpointGO:03157110.4TP53, CCND1

Molecular functions related to Laryngitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.2TP53, CCND1, ICK, AURKA, CTSD, BSG
2protein kinase bindingGO:01990111.0TP53, NME1, AURKA, CCND1
3enzyme bindingGO:01989910.7CCND1, BIRC5, TP53, GSTM1

Products for genes affiliated with Laryngitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Laryngitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet