MCID: LRY019
MIFTS: 57

Laryngitis

Categories: Respiratory diseases, Infectious diseases

Aliases & Classifications for Laryngitis

MalaCards integrated aliases for Laryngitis:

Name: Laryngitis 12 41 14 69
Acute Laryngitis 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3437
MeSH 41 D007827
NCIt 46 C26811
SNOMED-CT 64 45913009
UMLS 69 C0023067

Summaries for Laryngitis

Disease Ontology : 12 A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

MalaCards based summary : Laryngitis, also known as acute laryngitis, is related to acute laryngitis and laryngeal tuberculosis, and has symptoms including throat irritation An important gene associated with Laryngitis is HRH2 (Histamine Receptor H2), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Akt Signaling. The drugs Omeprazole and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, thyroid and endothelial, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : 72 Laryngitis is inflammation of the larynx (voice box). Symptoms often include a hoarse voice and may... more...

Related Diseases for Laryngitis

Diseases in the Laryngitis family:

Chronic Laryngitis Viral Laryngitis
Acute Laryngitis

Diseases related to Laryngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 772)
# Related Disease Score Top Affiliating Genes
1 acute laryngitis 33.4 ATP12A ATP4A
2 laryngeal tuberculosis 33.0 ATP12A ATP4A
3 laryngeal disease 33.0 ATP12A ATP4A
4 chronic laryngitis 32.8 ATP12A ATP4A HRH2
5 pneumonia 29.9 IL1B IL6 TNF
6 burns 29.7 IL1B TNF
7 leishmaniasis 29.7 IL1B TGFB1 TNF
8 aspiration pneumonia 29.6 ATP12A ATP4A
9 sudden infant death syndrome 29.6 IL1B IL6 TNF
10 acquired immunodeficiency syndrome 29.6 IL1B IL6 TNF
11 myelitis 29.5 IL6 TNF
12 esophagitis 29.5 HRH2 IL1B IL6 TGFB1
13 pertussis 29.5 IL1B IL6 TNF
14 tonsillitis 29.4 IL1B IL6 TNF
15 gastroenteritis 29.4 IL1B IL6 TNF
16 lung disease 29.3 IL1B TGFB1 TNF
17 duodenitis 29.3 ATP12A ATP4A
18 prostatitis 29.2 IL1B IL6 TGFB1 TNF
19 silicosis 29.2 IL1B TGFB1 TNF
20 aphthous stomatitis 29.1 IL1B IL6 TNF
21 pericarditis 29.1 IL1B IL6 TNF
22 arthritis 29.1 IL1B IL6 TNF
23 gingivitis 29.1 IL1B IL6 TNF
24 peritonitis 29.1 IL1B IL6 TNF
25 graft-versus-host disease 29.1 IL1B IL6 TNF
26 hernia, hiatus 29.0 ATP12A ATP4A
27 aspiration pneumonitis 28.8 ATP12A ATP4A HRH2
28 rheumatoid arthritis 28.7 IL1B IL6 TGFB1 TNF
29 paine syndrome 28.5 ATP12A ATP4A IL1B
30 asthma 28.5 HRH2 IL1B IL6 TNF
31 systemic lupus erythematosus 28.5 IL1B IL6 TGFB1 TNF
32 laryngeal cleft 12.3
33 laryngeal papillomatosis 12.3
34 laryngeal web, familial 12.3
35 viral laryngitis 12.1
36 congenital laryngeal palsy 12.1
37 laryngeal cartilage cancer 12.0
38 laryngeal abductor paralysis 12.0
39 laryngeal small cell carcinoma 12.0
40 supraglottic laryngeal cancer 11.9
41 laryngeal adenoid cystic carcinoma 11.9
42 laryngeal mucoepidermoid carcinoma 11.9
43 laryngeal adductor paralysis 11.9
44 congenital laryngeal cyst 11.9
45 laryngeal atresia, encephalocele, and limb deformities 11.9
46 hirschsprung disease with heart defects, laryngeal anomalies, and preaxial polydactyly 11.8
47 laryngeal neuroendocrine tumor 11.8
48 larynx cancer 11.8
49 laryngeal abductor paralysis with cerebellar ataxia and motor neuropathy 11.7
50 vater-like defects with pulmonary hypertension, laryngeal webs, and growth deficiency 11.7

Comorbidity relations with Laryngitis via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Deficiency Anemia Esophagitis
Heart Disease Hypertension, Essential
Ischemic Heart Disease Pharyngitis

Graphical network of the top 20 diseases related to Laryngitis:



Diseases related to Laryngitis

Symptoms & Phenotypes for Laryngitis

UMLS symptoms related to Laryngitis:


throat irritation

MGI Mouse Phenotypes related to Laryngitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.63 ATP12A ATP4A HRH2 IL6 TGFB1 TNF
2 homeostasis/metabolism MP:0005376 9.56 ATP12A ATP4A FGF2 HRH2 IL1B IL6
3 neoplasm MP:0002006 9.02 FGF2 IL1B IL6 TGFB1 TNF

Drugs & Therapeutics for Laryngitis

Drugs for Laryngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 86)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
4 Racepinephrine Approved Phase 4 329-65-7
5
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 9579578 4594
6
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
7
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 54677470 5281106
8
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
9
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
10
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
11 Adrenergic Agents Phase 4,Phase 2,Phase 3
12 Adrenergic Agonists Phase 4
13 Adrenergic beta-2 Receptor Agonists Phase 4
14 Adrenergic beta-Agonists Phase 4
15 Anti-Allergic Agents Phase 4,Phase 3
16 Anti-Asthmatic Agents Phase 4,Phase 3
17 Anti-Inflammatory Agents Phase 4,Phase 3
18 Autonomic Agents Phase 4,Phase 3
19 Bronchodilator Agents Phase 4,Phase 3
20 Dermatologic Agents Phase 4,Phase 3
21
Fluticasone Phase 4,Phase 3 80474-14-2, 90566-53-3 22833648 62924
22 Fluticasone Propionate, Salmeterol Xinafoate Drug Combination Phase 4
23 glucocorticoids Phase 4,Phase 3
24 Hormone Antagonists Phase 4,Phase 3
25 Hormones Phase 4,Phase 3
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
27 Neurotransmitter Agents Phase 4,Phase 2,Phase 3
28 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
29 Respiratory System Agents Phase 4,Phase 3
30
Salmeterol xinafoate Phase 4 94749-08-3 56801
31 Gastrointestinal Agents Phase 4,Phase 2,Phase 3
32 Proton pump inhibitors Phase 4,Phase 2,Phase 3
33 Antiemetics Phase 4,Phase 3
34 Antineoplastic Agents, Hormonal Phase 4,Phase 3
35 BB 1101 Phase 4
36 Dexamethasone acetate Phase 4 1177-87-3
37 HIV Protease Inhibitors Phase 4
38
protease inhibitors Phase 4
39 Epinephryl borate Phase 4
40 Antacids Phase 4,Phase 2,Phase 3
41 Anti-Ulcer Agents Phase 4,Phase 2,Phase 3
42 Analgesics Phase 4,Phase 2,Phase 3
43 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
44 Anti-Inflammatory Agents, Non-Steroidal Phase 4
45 Antirheumatic Agents Phase 4
46 Cyclooxygenase Inhibitors Phase 4
47 Adrenergic alpha-Agonists Phase 4
48 Mydriatics Phase 4
49 Vasoconstrictor Agents Phase 4
50
Rabeprazole Approved, Investigational Phase 2, Phase 3 117976-89-3 5029

Interventional clinical trials:

(show all 25)

# Name Status NCT ID Phase Drugs
1 Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 Mcg BID Unknown status NCT00235053 Phase 4 fluticasone/salmeterol DISKUS 250/50
2 Chronic Posterior Laryngitis With Suspected Laryngopharyngeal Reflux Completed NCT00628667 Phase 4 Esomeprazole;Placebo
3 Efficacy and Safety of Meloxicam Suspension Versus Diclofenac Suspension or Nimesulide Suspension in Patients With a Diagnosis of Acute, Non-bacterial Pharyngitis, Pharyngotonsillitis or Laryngitis Completed NCT02229747 Phase 4 Meloxicam;Diclofenac;Nimesulide
4 Quality of Life Validation in Laryngitis Completed NCT00641264 Phase 4 Omeprazole
5 Community Care for Croup (RCT) Completed NCT01042145 Phase 4 Prednisone;Dexamethasone
6 The Effect and Safety of Low Dose Nebulized Epinephrine in Croup Recruiting NCT01664507 Phase 4 conventional dose epinephrine;low dose epinephrine
7 Safety and Efficacy of Lansoprazole 30mg Twice Daily in Treatment of Laryngitis Associated With Gastroesophageal Reflux Terminated NCT00369265 Phase 4 Lansoprazole
8 Laryngopharyngeal Reflux and Proton Pump Inhibitor (PPI) Treatment Completed NCT00204698 Phase 2, Phase 3 Aciphex
9 CLEARI (Clinical Efficacy Assessment on Recurrent Upper-Respiratory Tract Infections) Study Completed NCT01948856 Phase 3 J022X ST;Placebo
10 Treatment of Chronic Laryngitis With Amitriptyline Suspended NCT02552225 Phase 2, Phase 3 Amitriptyline
11 Trial of the Treatment of Chronic Laryngitis With Amitryptiline Terminated NCT02434523 Phase 2, Phase 3 Amitriptyline
12 Management of Recurrent Croup Terminated NCT01748162 Phase 3 Fluticasone;Prednisolone IF needed
13 Efficacy of Nebulized Beclomethasone Dipropionate (BDP) in the Treatment of Moderate Croup Terminated NCT00938353 Phase 3 beclomethasone dipropionate suspension for nebulisation 800 mcg/2 ml;Placebo solution for nebulisation 2 ml
14 Treatment of Acute Tracheitis and Laryngitis With Essential Oils of Aromatic Plants Completed NCT00611390 Phase 1, Phase 2
15 Comparing Different Ways of Delivering Humidity to Children With Croup Completed NCT00230841 Phase 2
16 Positive Predictive Value of the Dx-pH Probe for Predicting PPI Response in LPR Unknown status NCT01755221
17 Comparison Between Budesonide and Dexamethasone Treatments for Respiratory Discomfort After Extubation on Children Unknown status NCT02056379 Budesonide;Dexamethasone
18 Laryngeal and Esophageal EGF-r Expression in Patients With Reflux Laryngitis Completed NCT01806220
19 Salivary Epidermal Growth Factor (EGF) Concentration Before and After Treatment of Reflux Laryngitis Completed NCT01389401 omeprazole
20 Prospective Double-blinded Randomized Controlled Trial of 12-weeks High Dose Rabeprazole (Pariet) in the Treatment of Reflux Laryngitis in Chinese Patients Completed NCT00517114 Rabeprazole 20mg twice daily
21 Non Interventional Study (NIS) Regarding the Application of Ectoin Mund- & Rachenspray in Patients With Acute Laryngitis and/or Acute Pharyngitis Completed NCT02160912
22 Inter-rater Reliability of the Reflux Finding Score Among Gastroenterologists Completed NCT02048449
23 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275 Amoxicillin and clavulanate
24 The Effect of Zinc Acetate Lozenges on the Rate of Recovery From the Common Cold Enrolling by invitation NCT03309995
25 A Cluster Controlled Trial Comparing Three Methods of Disseminating Practice Guidelines for Children With Croup Terminated NCT00147849

Search NIH Clinical Center for Laryngitis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: laryngitis

Genetic Tests for Laryngitis

Anatomical Context for Laryngitis

MalaCards organs/tissues related to Laryngitis:

38
Lymph Node, Thyroid, Endothelial, Lung, T Cells, Skin, Tongue

Publications for Laryngitis

Articles related to Laryngitis:

(show top 50) (show all 3493)
# Title Authors Year
1
Korean survey data reveals an association of chronic laryngitis with tinnitus in men. ( 29324903 )
2018
2
Laryngeal squamous cell papilloma is highly associated with human papillomavirus. ( 29447361 )
2018
3
Pediatric laryngeal cleft repair and dysphagia. ( 29287871 )
2018
4
Metastatic laryngeal large cell neuroendocrine carcinoma: A rare case of presentation and extreme tumor burden. ( 29194700 )
2018
5
Laryngeal ultrasound for the diagnosis of laryngomalacia in infants. ( 29405660 )
2018
6
Simple laryngeal suspension procedure by suturing the digastric muscle to the periosteum of the mandible in neck dissection for tongue cancer. ( 29395281 )
2018
7
Laryngeal tuberculosis: a rare cause of critical airway obstruction. ( 29348284 )
2018
8
Pulmonary melioidosis with laryngeal involvement: an unusual site of infection. ( 29374089 )
2018
9
Identification of gene expression models for laryngeal squamous cell carcinoma using co-expression network analysis. ( 29443735 )
2018
10
Prevalence of Laryngeal Cleft in Pediatric Patients With Esophageal Atresia. ( 29270628 )
2018
11
Outcomes of Onabotulinum Toxin A Treatment for Adductor Spasmodic Dysphonia and Laryngeal Tremor. ( 29423509 )
2018
12
Evaluation of treatment outcomes in patients with supraglottic laryngeal cancer in Ontario, Canada: A population-based study. ( 29412495 )
2018
13
Laryngeal papillomatosis in Senegal: A ten-year experience. ( 29396224 )
2018
14
Indications for Surgical Repair of Type 1 Laryngeal Cleft. ( 29338291 )
2018
15
Pulmonary and laryngeal tuberculosis in a 25-weeks' gestation parturient, diagnosed after failed tracheal intubation. ( 29017739 )
2018
16
Cyclooxygenase-2 Inhibition Enhances Proliferation of NKT Cells Derived from Patients with Laryngeal Cancer. ( 28739688 )
2017
17
There is no correlation between signs of reflux laryngitis and reflux oesophagitis in patients with gastro-oesophageal reflux disease symptoms. ( 29165435 )
2017
18
[Forkhead domain inhibitor-6 (FDI-6) increases apoptosis and inhibits invasion and migration of laryngeal carcinoma cells by down-regulating nuclear FoxM1]. ( 28502298 )
2017
19
Assessment of the feeding Swallowing Impact Survey as a quality of life measure in children with laryngeal cleft before and after repair. ( 28688569 )
2017
20
Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3I^-involved Wnt/I^-catenin pathway. ( 28122350 )
2017
21
A retrospective analysis of seven patients with acquired immunodeficiency syndrome and pharyngeal and/or laryngeal Talaromyces marneffei infection. ( 28130931 )
2017
22
A Mild Laryngeal Cleft Causes Severe Symptoms. ( 29232350 )
2017
23
Laryngeal alveolar soft part sarcoma: A case report of a rare malignancy in an atypical location. ( 28131550 )
2017
24
Factors Associated With Infectious Laryngitis: A Retrospective Review of 15 Cases. ( 28397557 )
2017
25
A positive-feedback loop between tumour infiltrating activated Treg cells and type 2-skewed macrophages is essential for progression of laryngeal squamous cell carcinoma. ( 28949956 )
2017
26
Association between interleukin-17 gene polymorphisms and the risk of laryngeal cancer in a Chinese population. ( 28362993 )
2017
27
Minimally invasive endoscopic treatment for pediatric combined high grade stenosis as a laryngeal manifestation of epidermolysis bullosa. ( 28012513 )
2017
28
The primary growth of laryngeal squamous cell carcinoma cells in vitro is effectively supported by paired cancer-associated fibroblasts alone. ( 28475003 )
2017
29
Nonpromoter methylation of the CDKN2A gene with active transcription is associated with improved locoregional control in laryngeal squamous cell carcinoma. ( 28102032 )
2017
30
Lewis-Sumner Syndrome Manifesting as Unilateral Vocal Fold Paresis and Laryngeal Fasciculations. ( 28781097 )
2017
31
MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1. ( 28122647 )
2017
32
The expression and function of epithelial membrane protein 1 in laryngeal carcinoma. ( 27909719 )
2017
33
Allergic laryngitis: unraveling the myths. ( 28266945 )
2017
34
Neutrophil infiltration mediated by CXCL5 accumulation in the laryngeal squamous cell carcinoma microenvironment: A mechanism by which tumour cells escape immune surveillance. ( 27876461 )
2017
35
Analysis of Association Between MGMT and p53 Gene Single Nucleotide Polymorphisms and Laryngeal Cancer. ( 28739733 )
2017
36
MRSA chronic bacterial laryngitis: A growing problem. ( 29086424 )
2017
37
Sleep-Related Laryngeal Stridor in Opsoclonus Myoclonus Syndrome. ( 28823798 )
2017
38
Aberrant expression of CDK8 regulates the malignant phenotype and associated with poor prognosis in human laryngeal squamous cell carcinoma. ( 28220308 )
2017
39
'A most malignant malady': a rare case of laryngeal tuberculosis in epidermal growth factor receptor mutant lung adenocarcinoma. ( 28994257 )
2017
40
Laryngeal stridor in rheumatoid arthritis. ( 28947548 )
2017
41
Laryngeal Cryptococcosis Associated With Inhaled Corticosteroid Use: Case Reports and Literature Review. ( 29209614 )
2017
42
Rigid laryngoscope manifestations of 61 cases of modern laryngeal tuberculosis. ( 29201220 )
2017
43
Ascorbic Acid Induces Necrosis in Human Laryngeal Squamous Cell Carcinoma via ROS, PKC, and Calcium Signaling. ( 27211910 )
2017
44
Clinical Significance of Low 2-Methoxyestradiol Levels in Serum and Tissue of Recurrent Juvenile-Onset Laryngeal Papillomatosis. ( 29110580 )
2017
45
Herpes Simplex Virus Laryngitis Presenting as Airway Obstruction: A Case Report and Literature Review. ( 28397560 )
2017
46
Genetic polymorphisms and plasma levels of BCL11A contribute to the development of laryngeal squamous cell carcinoma. ( 28225775 )
2017
47
Laryngeal tumours and radiotherapy dose to the cricopharyngeus are predictive of death from aspiration pneumonia. ( 28024728 )
2017
48
Conservative surgery for laryngeal chondrosarcoma: a review of the most recently proposed approaches. ( 28059901 )
2017
49
CCL20/CCR6 promotes cell proliferation and metastasis in laryngeal cancer by activating p38 pathway. ( 27916417 )
2017
50
Gardasil Vaccination for Recurrent Laryngeal Papillomatosis in Adult Men Second Report: Negative Conversion of HPV in Laryngeal Secretions. ( 28866231 )
2017

Variations for Laryngitis

Expression for Laryngitis

Search GEO for disease gene expression data for Laryngitis.

Pathways for Laryngitis

Pathways related to Laryngitis according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.32 ATP12A ATP4A IL1B IL6 TGFB1 TNF
2
Show member pathways
13.27 FGF2 IL1B IL6 TGFB1 TNF
3
Show member pathways
13.23 FGF2 IL1B IL6 TGFB1 TNF
4
Show member pathways
13.16 FGF2 IL1B IL6 TGFB1 TNF
5
Show member pathways
12.74 IL1B IL6 TGFB1 TNF
6 12.65 FGF2 IL1B TGFB1 TNF
7
Show member pathways
12.53 FGF2 IL1B IL6 TGFB1 TNF
8
Show member pathways
12.5 IL1B IL6 TGFB1 TNF
9
Show member pathways
12.49 FGF2 IL1B IL6 TNF
10
Show member pathways
12.47 FGF2 IL6 TGFB1 TNF
11
Show member pathways
12.43 IL1B IL6 TGFB1 TNF
12
Show member pathways
12.33 IL1B IL6 TGFB1 TNF
13 12.32 IL6 TGFB1 TNF
14
Show member pathways
12.24 IL1B IL6 TNF
15
Show member pathways
12.24 IL1B IL6 TNF
16 12.21 FGF2 TGFB1 TNF
17
Show member pathways
12.18 IL1B IL6 TNF
18
Show member pathways
12.17 IL1B TGFB1 TNF
19
Show member pathways
12.13 IL6 TGFB1 TNF
20 12.12 IL1B IL6 TGFB1 TNF
21
Show member pathways
12.11 IL1B IL6 TNF
22 12.1 IL6 TGFB1 TNF
23 12.09 IL1B IL6 TNF
24
Show member pathways
12.08 FGF2 TGFB1 TNF
25
Show member pathways
12.07 IL1B IL6 TNF
26 11.99 FGF2 IL6 TGFB1
27 11.98 IL6 TGFB1 TNF
28 11.96 IL1B TGFB1 TNF
29 11.89 IL1B IL6 TNF
30 11.87 IL1B IL6 TGFB1
31 11.87 IL1B IL6 TGFB1 TNF
32 11.83 IL1B IL6 TNF
33 11.82 FGF2 IL6 TGFB1
34
Show member pathways
11.8 IL1B IL6 TGFB1
35
Show member pathways
11.8 IL1B IL6 TGFB1 TNF
36 11.75 IL1B IL6 TGFB1 TNF
37 11.72 IL1B IL6 TGFB1 TNF
38 11.69 IL1B IL6 TNF
39 11.66 IL1B IL6 TGFB1 TNF
40 11.62 IL6 TGFB1 TNF
41
Show member pathways
11.6 IL1B IL6 TNF
42 11.53 IL1B IL6 TNF
43 11.49 IL1B IL6 TGFB1 TNF
44 11.47 IL1B IL6 TNF
45 11.46 IL1B TGFB1 TNF
46 11.45 FGF2 IL6 TGFB1
47 11.41 IL1B IL6 TNF
48 11.41 FGF2 IL1B IL6 TGFB1 TNF
49
Show member pathways
11.29 TGFB1 TNF
50 11.28 IL1B IL6

GO Terms for Laryngitis

Cellular components related to Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 ATP4A FGF2 IL1B IL6 TGFB1 TNF

Biological processes related to Laryngitis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.96 FGF2 IL1B IL6 TGFB1
2 immune response GO:0006955 9.94 HRH2 IL1B IL6 TNF
3 inflammatory response GO:0006954 9.9 IL1B IL6 TGFB1 TNF
4 positive regulation of gene expression GO:0010628 9.89 IL1B IL6 TGFB1 TNF
5 positive regulation of transcription, DNA-templated GO:0045893 9.88 FGF2 IL1B IL6 TGFB1 TNF
6 leukocyte migration GO:0050900 9.87 IL1B TGFB1 TNF
7 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.86 FGF2 TGFB1 TNF
8 positive regulation of protein phosphorylation GO:0001934 9.84 IL1B TGFB1 TNF
9 positive regulation of protein kinase B signaling GO:0051897 9.83 FGF2 TGFB1 TNF
10 MAPK cascade GO:0000165 9.83 FGF2 IL1B TGFB1 TNF
11 activation of MAPK activity GO:0000187 9.79 FGF2 IL1B TNF
12 positive regulation of DNA binding transcription factor activity GO:0051091 9.78 IL1B IL6 TNF
13 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.73 IL6 TGFB1 TNF
14 cellular response to organic cyclic compound GO:0071407 9.72 IL1B TGFB1 TNF
15 regulation of angiogenesis GO:0045765 9.71 FGF2 IL6
16 positive regulation of blood vessel endothelial cell migration GO:0043536 9.71 FGF2 TGFB1
17 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.71 IL1B TNF
18 digestive tract development GO:0048565 9.71 HRH2 TGFB1
19 negative regulation of mitotic cell cycle GO:0045930 9.7 TGFB1 TNF
20 positive regulation of phagocytosis GO:0050766 9.7 IL1B TNF
21 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.7 FGF2 TGFB1
22 negative regulation of blood vessel endothelial cell migration GO:0043537 9.7 FGF2 TGFB1
23 protein import into nucleus, translocation GO:0000060 9.69 TGFB1 TNF
24 positive regulation of interleukin-8 production GO:0032757 9.69 IL1B TNF
25 positive regulation of MAP kinase activity GO:0043406 9.69 FGF2 TGFB1 TNF
26 positive regulation of vascular endothelial growth factor production GO:0010575 9.68 IL1B TGFB1
27 positive regulation of protein complex assembly GO:0031334 9.68 TGFB1 TNF
28 negative regulation of myoblast differentiation GO:0045662 9.68 TGFB1 TNF
29 positive regulation of NF-kappaB import into nucleus GO:0042346 9.67 IL1B TNF
30 positive regulation of chemokine production GO:0032722 9.67 IL6 TNF
31 positive regulation of histone acetylation GO:0035066 9.67 IL1B TGFB1
32 negative regulation of lipid catabolic process GO:0050995 9.65 IL1B TNF
33 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IL1B TNF
34 hyaluronan catabolic process GO:0030214 9.64 FGF2 TGFB1
35 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.63 IL1B TNF
36 negative regulation of fat cell differentiation GO:0045599 9.63 IL6 TGFB1 TNF
37 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.62 ATP12A ATP4A
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 IL1B TNF
39 positive regulation of interleukin-6 production GO:0032755 9.61 IL1B IL6 TNF
40 negative regulation of lipid storage GO:0010888 9.58 IL6 TNF
41 positive regulation of chemokine biosynthetic process GO:0045080 9.58 IL1B TNF
42 regulation of establishment of endothelial barrier GO:1903140 9.57 IL1B TNF
43 positive regulation of fever generation GO:0031622 9.54 IL1B TNF
44 positive regulation of cell division GO:0051781 9.5 FGF2 IL1B TGFB1
45 sequestering of triglyceride GO:0030730 9.49 IL1B TNF
46 protein kinase B signaling GO:0043491 9.43 IL1B TGFB1 TNF
47 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 IL1B TNF
48 positive regulation of mononuclear cell migration GO:0071677 9.37 TGFB1 TNF
49 regulation of receptor activity GO:0010469 9.35 FGF2 IL1B IL6 TGFB1 TNF
50 lipopolysaccharide-mediated signaling pathway GO:0031663 9.33 IL1B TGFB1 TNF

Molecular functions related to Laryngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.43 FGF2 IL6 TGFB1
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP12A ATP4A
3 cytokine activity GO:0005125 9.02 FGF2 IL1B IL6 TGFB1 TNF
4 hydrogen:potassium-exchanging ATPase activity GO:0008900 8.96 ATP12A ATP4A

Sources for Laryngitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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