MCID: LRY002
MIFTS: 20

Laryngostenosis

Categories: Respiratory diseases, Oral diseases

Aliases & Classifications for Laryngostenosis

MalaCards integrated aliases for Laryngostenosis:

Name: Laryngostenosis 12 41 14 69
Stenosis of Larynx 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11527
ICD10 32 J38.6
ICD9CM 34 478.74
MeSH 41 D007829
NCIt 46 C79608
SNOMED-CT 64 195864007 75547007
UMLS 69 C0023075

Summaries for Laryngostenosis

MalaCards based summary : Laryngostenosis, is also known as stenosis of larynx. An important gene associated with Laryngostenosis is FOXL2 (Forkhead Box L2). The drugs Cyclophosphamide and rituximab have been mentioned in the context of this disorder.

Related Diseases for Laryngostenosis

Symptoms & Phenotypes for Laryngostenosis

Drugs & Therapeutics for Laryngostenosis

Drugs for Laryngostenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
2
rituximab Approved Phase 3 174722-31-7 10201696
3 Alkylating Agents Phase 3
4 Antirheumatic Agents Phase 3
5 Immunosuppressive Agents Phase 3
6
Temazepam Approved, Investigational 846-50-4 5391
7 Anti-Bacterial Agents
8 Antibiotics, Antitubercular
9 Mitomycins
10 Nucleic Acid Synthesis Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Clinical Trial Comparing the Safety and Efficacy of Rituximab Versus Oral Cyclophosphamide in Severe Forms of Mucous Membrane Pemphigoid Not yet recruiting NCT03295383 Phase 3 Rituximab 1g IV;Cyclophosphamide 50Mg Oral Tablet;Placebo of Rituximab;Placebo Oral Tablet
2 Clinical Trial of Stem Cell Based Tissue Engineered Laryngeal Implants Recruiting NCT01977911 Phase 1, Phase 2
3 Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells Recruiting NCT03130374 Phase 1, Phase 2
4 Functional Modeling of the Pediatric Airway Completed NCT01690078
5 Study of Mitomycin-C Application in Laryngotracheal Stenosis Recruiting NCT01523275 Mitomycin -C
6 Treatment Alternatives in iSGS (NoAAC PR-02 Study) Active, not recruiting NCT02481817
7 Laryngeal Allograft Transplantation Enrolling by invitation NCT03269396
8 Brainstem Dysfunction Involvement in the Pathogenesis of Pierre Robin Sequence Not yet recruiting NCT03423017

Search NIH Clinical Center for Laryngostenosis

Cochrane evidence based reviews: laryngostenosis

Genetic Tests for Laryngostenosis

Anatomical Context for Laryngostenosis

Publications for Laryngostenosis

Articles related to Laryngostenosis:

# Title Authors Year
1
Severe feeding problems and congenital laryngostenosis in a patient with 3q23 deletion. ( 9266197 )
1997
2
Three cases of congenital laryngostenosis with different etiologies. ( 18885519 )
1948
3
OPERATIVE RELIEF OF LARYNGOSTENOSIS. ( 17865603 )
1927

Variations for Laryngostenosis

Expression for Laryngostenosis

Search GEO for disease gene expression data for Laryngostenosis.

Pathways for Laryngostenosis

GO Terms for Laryngostenosis

Molecular functions related to Laryngostenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 8.96 FOXL2 ZBED1
2 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 8.62 FOXL2 ZBED1

Sources for Laryngostenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....