LF
MCID: LSS003
MIFTS: 40

Lassa Fever (LF) malady

Infectious diseases, Rare diseases categories
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Summaries for Lassa Fever

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Sources:
8Disease Ontology, 4CDC, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection, has material basis in lassa virus, which is transmitted by multimammate rat of the genus mastomys. the infection has symptom fever, has symptom retrosternal pain, has symptom sore throat, has symptom back pain, has symptom cough, has symptom abdominal pain, has symptom vomiting, has symptom diarrhea, has symptom conjunctivitis, has symptom facial swelling, has symptom proteinuria (protein in the urine), and has symptom mucosal bleeding.

MalaCards: Lassa Fever, also known as hemorrhagic fevers, viral, is related to lymphocytic choriomeningitis and vaccinia, and has symptoms including diarrhea, conjunctival injection/chemosis/red eye and spontaneous abortions. An important gene associated with Lassa Fever is DAG1 (dystroglycan 1 (dystrophin-associated glycoprotein 1)), and among its related pathways is Allograft rejection. Affiliated tissues include eye, testes and t cells.

CDC:4 Lassa fever is an acute viral illness that occurs in west Africa. The illness was discovered in 1969 when two missionary nurses died in Nigeria. The virus is named after the town in Nigeria where the first cases occurred. The virus, a member of the virus family Arenaviridae, is a single-stranded RNA virus and is zoonotic, or animal-borne.

Wikipedia:65 Lassa fever or Lassa hemorrhagic fever (LHF) is an acute viral hemorrhagic fever caused by the Lassa... more...

Aliases & Classifications for Lassa Fever

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 35MeSH, 58SNOMED-CT, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases


Characteristics (Orphanet epidemiological data):

49
lassa fever:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

lassa fever 8 10 45 49 62
hemorrhagic fevers, viral 62
lassa hemorrhagic fever 49
lf 49


External Ids:

Disease Ontology8 DOID:9537
MeSH35 D007835
MESH via Orphanet36 D007835
ICD10 via Orphanet26 A96.2
SNOMED-CT58 19065005
SNOMED-CT via Orphanet59 19065005
UMLS via Orphanet63 C0023092
ICD1025 A96.2

Related Diseases for Lassa Fever

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lassa Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1lymphocytic choriomeningitis30.5GP2, DAG1
2vaccinia10.4
3hemorrhagic fever10.4
4sensorineural hearing loss10.3
5rift valley fever10.2
6yellow fever10.2
7hepatitis a10.2
8hepatitis10.2
9leprosy10.2
10smallpox10.2
11viral hemorrhagic fever10.2

Graphical network of diseases related to Lassa Fever:



Diseases related to lassa fever

Symptoms for Lassa Fever

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8Disease Ontology
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Symptoms:

8 (show all 41)
  • diarrhea
  • conjunctival injection/chemosis/red eye
  • spontaneous abortions
  • leukopenia/hypoleukocytosis
  • lymphadenopathy/polyadenopathies
  • palpebral edema/periorbital edema
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • acute diarrhea
  • fever
  • conjunctivitis
  • vomiting
  • abdominal pain
  • retrosternal pain
  • sore throat
  • back pain
  • facial swelling
  • proteinuria (protein in the urine)
  • mucosal bleeding
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • pharyngitis
  • articular/joint pain/arthralgia
  • fever/chilling
  • asthenia/fatigue/weakness
  • obnubilation/coma/lethargia/desorientation
  • cranial hypertension
  • hearing loss/hypoacusia/deafness
  • early death/lethality
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • seizures/epilepsy/absences/spasms/status epilepticus
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • cutaneous rash
  • thoracic/chest pain
  • dizziness
  • facial pain/cephalalgia/migraine
  • thrombocytopenia/thrombopenia
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • acute abdominal pain/colic
  • myalgia/muscular pain
  • cough
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Lassa Fever

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Lassa Fever

Search NIH Clinical Center for Lassa Fever

Genetic Tests for Lassa Fever

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Anatomical Context for Lassa Fever

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Sources:
33MalaCards
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MalaCards organs/tissues related to Lassa Fever:

33
Eye, Testes, T cells, Lung

Animal Models for Lassa Fever or affiliated genes

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Publications for Lassa Fever

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Sources:
52PubMed
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Articles related to Lassa Fever:

(show top 50)    (show all 228)
idTitleAuthorsYear
1
Production of CXC and CC Chemokines by Human Antigen-Presenting Cells in Response to Lassa Virus or Closely Related Immunogenic Viruses, and in Cynomolgus Monkeys with Lassa Fever. (24421914)
2014
2
Advanced vaccine candidates for Lassa fever. (23202493)
2012
3
Guidance for contact tracing of cases of Lassa fever, Ebola or Marburg haemorrhagic fever on an airplane: results of a European expert consultation. (23170851)
2012
4
Hospital-based surveillance for Lassa fever in Edo State, Nigeria, 2005-2008. (22594713)
2012
5
Pathogenesis of Lassa fever. (23202452)
2012
6
Aeromedical evacuation using an aircraft transit isolator of a patient with Lassa fever. (22606871)
2012
7
Pathogenesis of Lassa fever in cynomolgus macaques. (21548931)
2011
8
Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever. (21820469)
2011
9
Hydrogen peroxide vapour decontamination of a critical care unit room used to treat a patient with Lassa fever. (20451295)
2010
10
Imported Lassa fever, Pennsylvania, USA, 2010. (20875288)
2010
11
T cell-dependence of Lassa fever pathogenesis. (20360949)
2010
12
The first case of Lassa fever imported from Mali to the United Kingdom, February 2009. (19317988)
2009
13
Safety, immunogenicity, and efficacy of the ML29 reassortant vaccine for Lassa fever in small non-human primates. (18692539)
2008
14
Mastomys natalensis and Lassa fever, West Africa. (17326956)
2006
15
Lassa fever, Nigeria, 2003 and 2004. (16355508)
2005
16
The public health response to a case of Lassa fever in London in 2000. (15001300)
2004
17
Imported Lassa fever in Germany: surveillance and management of contact persons. (12746770)
2003
18
Lassa fever. (11987809)
2002
19
Lassa fever. (12138522)
2002
20
Short communication: Lassa fever in Sierra Leone: UN peacekeepers are at risk. (11251899)
2001
21
Murine immune responses to mucosally delivered Salmonella expressing Lassa fever virus nucleoprotein. (10618553)
2000
22
Effective vaccine for lassa fever. (10888616)
2000
23
Lassa fever imported to England. (10769487)
2000
24
The story of Lassa fever. Part I: Discovering the disease. (1614671)
1992
25
Lassa fever. (1995110)
1991
26
Acute sensorineural deafness in Lassa fever. (2214077)
1990
27
Deafness associated with Lassa fever. (2214082)
1990
28
Detection of Lassa virus RNA in specimens from patients with Lassa fever by using the polymerase chain reaction. (2279999)
1990
29
Plasma from patients with severe Lassa fever profoundly modulates f-met-leu-phe induced superoxide generation in neutrophils. (2554951)
1989
30
An imported case of Lassa fever with late appearance of polyserositis. (3171229)
1988
31
Pediatric Lassa fever: a review of 33 Liberian cases. (3826501)
1987
32
A prospective study of the epidemiology and ecology of Lassa fever. (3805771)
1987
33
Clinical virology of Lassa fever in hospitalized patients. (3805773)
1987
34
Lassa virus hepatitis: a study of fatal Lassa fever in humans. (3953952)
1986
35
Use of monoclonal antibody for the detection of Lassa virus antibody and antigen in patients with Lassa fever. (3523183)
1986
36
Journal of Infection Control Nursing. Nursing the isolated patient: Lassa fever. (3640375)
1986
37
Management of Lassa fever. (2867274)
1986
38
Patients with suspected Lassa fever in London during 1984. (3080068)
1986
39
Endemic Lassa fever in Liberia. IV. Selection of optimally effective plasma for treatment by passive immunization. (3898484)
1985
40
The use of Lassa fever convalescent plasma in Nigeria. (6464130)
1984
41
Endemic Lassa fever in Liberia. II. Serological and virological findings in hospital patients. (6390808)
1984
42
Lassa fever antibodies in hospital personnel in the Plateau State of Nigeria. (463337)
1979
43
Epidemiological aspect of the 1976 Pankshin Lassa fever outbreak. (463336)
1979
44
Lassa fever (LF) and Marburg disease (MVD): occurrences, origins and diagnoses. (567823)
1978
45
The Lassa fever crisis. (832782)
1977
46
Lassa fever. (1264786)
1976
47
Lassa fever (arenaviruses) as a public health problem. (1026322)
1976
48
Unrecognized diseases in Africa. II. Lassa fever. (1165154)
1975
49
Hoosiers abroad--report of a case of Lassa fever. (4604539)
1974
50
Lassa fever. A study of 23 hospital cases. (5046379)
1972

Variations for Lassa Fever

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Expression for genes affiliated with Lassa Fever

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lassa Fever

Search GEO for disease gene expression data for Lassa Fever.

Pathways for genes affiliated with Lassa Fever

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN
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Pathways related to Lassa Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5IFNG, DAG1

Compounds for genes affiliated with Lassa Fever

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GO Terms for genes affiliated with Lassa Fever

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Products for genes affiliated with Lassa Fever

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lassa Fever

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet