MCID: LSS003
MIFTS: 37

Lassa Fever malady

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Lassa Fever

About this section
Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 51Orphanet, 36MeSH, 2CDC, 65UMLS, 27ICD10, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Lassa Fever:

Name: Lassa Fever 10 47 12 51 36 2 65
Lassa Hemorrhagic Fever 51
 
Lf 51

Characteristics:

Orphanet epidemiological data:

51
lassa fever:
Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology10 DOID:9537
ICD1027 A96.2
MeSH36 D007835
Orphanet51 99824
SNOMED-CT59 19065005
ICD10 via Orphanet28 A96.2
MESH via Orphanet37 D007835
UMLS via Orphanet66 C0023092
UMLS65 C0023092

Summaries for Lassa Fever

About this section
Disease Ontology:10 A viral infectious disease that results in infection, has material basis in Lassa virus, which is transmitted by multimammate rat of the genus Mastomys. The infection has symptom fever, has symptom retrosternal pain, has symptom sore throat, has symptom back pain, has symptom cough, has symptom abdominal pain, has symptom vomiting, has symptom diarrhea, has symptom conjunctivitis, has symptom facial swelling, has symptom proteinuria (protein in the urine), and has symptom mucosal bleeding.

MalaCards based summary: Lassa Fever, also known as lassa hemorrhagic fever, is related to hemorrhagic fever and breast cancer, and has symptoms including abnormality of the menstrual cycle, abnormality of temperature regulation and spontaneous abortion. An important gene associated with Lassa Fever is DAG1 (Dystroglycan 1). Affiliated tissues include breast, lung and skin.

Wikipedia:68 Lassa fever or Lassa hemorrhagic fever (LHF) is an acute viral hemorrhagic fever caused by the Lassa... more...

Related Diseases for Lassa Fever

About this section

Graphical network of the top 20 diseases related to Lassa Fever:



Diseases related to lassa fever

Symptoms for Lassa Fever

About this section

Symptoms:

 51 10 (show all 41)
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • fever/chilling
  • asthenia/fatigue/weakness
  • spontaneous abortions
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • conjunctival injection/chemosis/red eye
  • palpebral edema/periorbital edema
  • dizziness
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • pharyngitis
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • acute diarrhea
  • thoracic/chest pain
  • cough
  • facial pain/cephalalgia/migraine
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • leukopenia/hypoleukocytosis
  • thrombocytopenia/thrombopenia
  • hearing loss/hypoacusia/deafness
  • cutaneous rash
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • lymphadenopathy/polyadenopathies
  • cranial hypertension
  • seizures/epilepsy/absences/spasms/status epilepticus
  • obnubilation/coma/lethargia/desorientation
  • early death/lethality
  • fever
  • retrosternal pain
  • sore throat
  • back pain
  • abdominal pain
  • vomiting
  • diarrhea
  • conjunctivitis
  • facial swelling
  • proteinuria (protein in the urine)
  • mucosal bleeding

HPO human phenotypes related to Lassa Fever:

(show all 25)
id Description Frequency HPO Source Accession
1 abnormality of the menstrual cycle hallmark (90%) HP:0000140
2 abnormality of temperature regulation hallmark (90%) HP:0004370
3 spontaneous abortion hallmark (90%) HP:0005268
4 conjunctivitis typical (50%) HP:0000509
5 thrombocytopenia typical (50%) HP:0001873
6 leukopenia typical (50%) HP:0001882
7 diarrhea typical (50%) HP:0002014
8 nausea and vomiting typical (50%) HP:0002017
9 abdominal pain typical (50%) HP:0002027
10 migraine typical (50%) HP:0002076
11 vertigo typical (50%) HP:0002321
12 arthralgia typical (50%) HP:0002829
13 myalgia typical (50%) HP:0003326
14 periorbital edema typical (50%) HP:0100539
15 chest pain typical (50%) HP:0100749
16 recurrent pharyngitis typical (50%) HP:0100776
17 hearing impairment occasional (7.5%) HP:0000365
18 skin rash occasional (7.5%) HP:0000988
19 seizures occasional (7.5%) HP:0001250
20 sudden cardiac death occasional (7.5%) HP:0001645
21 abnormality of the pleura occasional (7.5%) HP:0002103
22 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
23 increased intracranial pressure occasional (7.5%) HP:0002516
24 lymphadenopathy occasional (7.5%) HP:0002716
25 reduced consciousness/confusion occasional (7.5%) HP:0004372

Drugs & Therapeutics for Lassa Fever

About this section

Drugs for Lassa Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RibavirinapprovedPhase 294836791-04-537542
Synonyms:
1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide
36791-04-5
437710-49-1
66510-90-5
AA-504/07617051
AB00430481
AC1L1XXZ
AC1Q1IDC
AC1Q4ZGS
AKOS001715163
BB_NC-0567
BPBio1_001195
BRN 0892462
BSPBio_001085
BSPBio_003352
C-Virin
CHEMBL1643
CID37542
Copegus
Copegus (TN)
Cotronak
D00423
DB00811
DRG-0028
DivK1c_000782
Drug: Ribavirin
EU-0101063
FT-0082885
HMS2090L15
HMS2094O09
HMS502H04
HSDB 6513
ICN-1229
IDI1_000782
Ibavyr
KBio1_000782
KBio2_002328
KBio2_004896
KBio2_007464
KBio3_002854
KBioGR_001804
KBioSS_002331
KS-1104
LS-1241
Lopac0_001063
MLS000028486
MLS002222317
Moderiba
MolPort-002-507-104
MolPort-002-885-856
NCGC00090726-01
NCGC00090726-03
NCGC00090726-04
NCGC00090726-05
NCGC00090726-06
NCGC00090726-07
NINDS_000782
 
NSC 163039
NSC163039
Prestwick3_000993
R 9644
R-964
R9644_SIGMA
RBV
RG-964
RIBAV
RTC
RTCA
RTP
Ravanex
Rebetol
Rebetol (TN)
Rebetron
Rebretron
Ribacine
Ribamide
Ribamidil
Ribamidyl
Ribasphere
Ribasphere (TN)
Ribasphere Ribapak
Ribav
Ribavirin
Ribavirin (JAN/USP/INN)
Ribavirin Capsules
Ribavirin Triphosphate
Ribavirin [USAN:INN]
Ribavirin-TP
Ribavirina
Ribavirina [INN-Spanish]
Ribavirine
Ribavirine [INN-French]
Ribavirinum
Ribavirinum [INN-Latin]
Ribovirin
Ro 20-9963/000
Ro-20-9963
S2504_Selleck
SCH 18908
SMP1_000261
SMR000058315
SPECTRUM1503938
SR-01000076112-3
Spectrum3_001876
Spectrum4_001252
Spectrum5_002075
Spectrum_001826
Tribavirin
UNII-49717AWG6K
Varazid
Vilona
Viramid
Viramide
Virazid
Virazide
Virazole
Virazole (Ribavirin) Inhalation Solution
Virazole (TN)
Virazole 5'-triphosphate
ZINC01035331
ribavirin
2Antiviral AgentsPhase 28071
3AntimetabolitesPhase 29454
4Anti-Infective AgentsPhase 217220

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment FacilitiesEnrolling by invitationNCT00992693Phase 2
2Seroprevalence and Incidence of Lassa Fever in the Rural Commune of Sibirila, District of Bougouni, MaliActive, not recruitingNCT02311387
3Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic FeverNot yet recruitingNCT02483260

Search NIH Clinical Center for Lassa Fever


Cochrane evidence based reviews: lassa fever

Genetic Tests for Lassa Fever

About this section

Anatomical Context for Lassa Fever

About this section

MalaCards organs/tissues related to Lassa Fever:

33
Breast, Lung, Skin, Liver, Prostate, Eye, T cells

Animal Models for Lassa Fever or affiliated genes

About this section

Publications for Lassa Fever

About this section

Articles related to Lassa Fever:

(show top 50)    (show all 250)
idTitleAuthorsYear
1
Liposomal cisplatin can overcome chemotherapy resistance of A2780 ovarian cancer cells by inducing the extrinsic apoptotic pathway. (24290409)
2014
2
Chediak-Higashi syndrome and premature exfoliation of primary teeth. (24474367)
2013
3
Altered expression of pannexin proteins in patients with temporal lobe epilepsy. (24146091)
2013
4
Long-term results of primary and secondary resections in patients with retroperitoneal soft tissue sarcoma. (22407355)
2012
5
Alexithymia and suicide ideation in a sample of patients with binge eating disorder. (22261978)
2012
6
Biological activity of truncated C-terminus human heat shock protein 72. (21094186)
2011
7
Synthesis and anticancer effects of some novel pyrazolo[3,4-d]pyrimidine derivatives by generating reactive oxygen species in human breast adenocarcinoma cells. (21315495)
2011
8
Diagnosis of male posterior urethral stricture: comparison of 64-MDCT urethrography vs. standard urethrography. (21165616)
2011
9
A patient with Wells' syndrome. (20500167)
2010
10
Prognostic significance and clinical relevance of the expression of the HER family of type I receptor tyrosine kinases in human laryngeal squamous cell carcinoma. (20149638)
2010
11
Successful treatment of molybdenum cofactor deficiency type A with cPMP. (20385644)
2010
12
Effect of pioglitazone and rosiglitazone on mediators of endothelial dysfunction, markers of angiogenesis and inflammatory cytokines in type-2 diabetes. (18758684)
2009
13
Whiplash and the turtle. (19509094)
2009
14
Lack of associations between several polymorphisms in cytokine genes and the risk of chronic obstructive pulmonary diseases in Taiwan. (18364273)
2008
15
Cancer cell-derived IL-1alpha induces IL-8 release in endothelial cells. (17622559)
2008
16
Natural and disease associated anti-myeloperoxidase (MPO) autoantibodies. (18558355)
2008
17
A genomewide search finds major susceptibility loci for gallbladder disease on chromosome 1 in Mexican Americans. (16400619)
2006
18
Melioidosis in the Americas. (17123994)
2006
19
Treatment of chronic hepatitis C virus in allogeneic bone marrow transplant recipients. (16062173)
2005
20
Medical management of vulvar intraepithelial neoplasia. (16205189)
2005
21
Vertebrobasilar ischemia and structural abnormalities of the vertebral arteries in active temporal arteritis and polymyalgia rheumatica--an ultrasonographic case-control study. (16331763)
2005
22
Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene. (14729613)
2004
23
PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein augments the transforming activity in a rat fibroblast cell line. (14972558)
2004
24
Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins. (14681217)
2004
25
Inhibition of cell proliferation by potential peroxisome proliferator-activated receptor (PPAR) gamma agonists and antagonists. (15517883)
2004
26
Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease. (12940924)
2003
27
Accumulation of mutant myocilins in ER leads to ER stress and potential cytotoxicity in human trabecular meshwork cells. (14680806)
2003
28
Catechol-O-methyltransferase genotype and dopamine regulation in the human brain. (12657658)
2003
29
A yeast model for the study of human DFNA5, a gene mutated in nonsyndromic hearing impairment. (12853124)
2003
30
Japanese spotted fever associated with multiorgan failure. (11810592)
2001
31
Risk factors and management of patients with upper limb deep vein thrombosis. (10631197)
2000
32
Endothelial lipase: a new member of the triglyceride lipase gene family. (10787175)
2000
33
Complete remission of unresectable hepatocellular carcinoma on healthy liver by the combination of aggressive surgery and high-dose-intensity chemotherapy by CPT-11. (11081458)
2000
34
The role of the carboxy terminus of tropoelastin in its assembly into the elastic fiber. (10761633)
1999
35
Association of increased immunostaining for inducible nitric oxide synthase and nitrotyrosine with fibroblast growth factor transformation in pancreatic cancer. (10088562)
1999
36
Oxidant stress, anti-oxidants, nitric oxide and essential fatty acids in peptic ulcer disease. (10102386)
1998
37
Assessment of benzodiazepine receptors using iodine-123-labeled iomazenil single-photon emission computed tomography in patients with ischemic cerebrovascular disease. A comparison with PET study. (9303025)
1997
38
Coronary arteriography in the presence of dextrocardia and situs inversus. (8924024)
1996
39
Expression of GTP-binding protein alpha subunits in human thymocytes. (7791744)
1995
40
The IFN pregnancy recognition hormone IFN-tau blocks both development and superantigen reactivation of experimental allergic encephalomyelitis without associated toxicity. (7544384)
1995
41
Coronary heart disease and insulin concentration in type II diabetic patients--results of a diabetes intervention study]. (1642023)
1992
42
Bromocriptine as an adjuvant to cyclosporine immunosuppression after heart transplantation. (2297260)
1990
43
Pancreatoblastoma: MR appearance. (2159494)
1990
44
Cauda equina syndrome complicating ankylosing spondylitis: MR features. (2723187)
1989
45
Effect of fluoride ingestion on dental fluorosis in sheep. (3592393)
1987
46
Sexual development and life of women with gonadal dysgenesis. (3612822)
1987
47
The alveolar soft-part sarcoma. A clinically malignant, neuro-endocrine tumor, possibly originating from the tissue composing the paraganglia. (1023823)
1976
48
Subpulmonary obstruction in congenitally corrected transposition of the great arteries due to ventricular membranous septal aneurysms. (986879)
1976
49
50

Variations for Lassa Fever

About this section

Expression for genes affiliated with Lassa Fever

About this section
Search GEO for disease gene expression data for Lassa Fever.

Pathways for genes affiliated with Lassa Fever

About this section

GO Terms for genes affiliated with Lassa Fever

About this section

Sources for Lassa Fever

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet