LF
MCID: LSS003
MIFTS: 40

Lassa Fever (LF) malady

Infectious category

Summaries for Lassa Fever

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection, has material basis in lassa virus, which is transmitted by multimammate rat of the genus mastomys. the infection has symptom fever, has symptom retrosternal pain, has symptom sore throat, has symptom back pain, has symptom cough, has symptom abdominal pain, has symptom vomiting, has symptom diarrhea, has symptom conjunctivitis, has symptom facial swelling, has symptom proteinuria (protein in the urine), and has symptom mucosal bleeding.

MalaCards: Lassa Fever, also known as hemorrhagic fevers, viral, is related to lymphocytic choriomeningitis and argentine hemorrhagic fever, and has symptoms including nausea/vomiting/regurgitation/merycism/hyperemesis, seizures/epilepsy/absences/spasms/status epilepticus and collapse/sudden death/cardiac arrest/cardiorespiratory arrest. An important gene associated with Lassa Fever is DAG1 (dystroglycan 1 (dystrophin-associated glycoprotein 1)). Affiliated tissues include lung, t cells and fetal lung.

Wikipedia:64 Lassa fever or Lassa hemorrhagic fever (LHF) is an acute viral hemorrhagic fever caused by the Lassa... more...

Aliases & Classifications for Lassa Fever

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
lassa fever:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

lassa fever 8 10 45 49 61
hemorrhagic fevers, viral 61
lassa hemorrhagic fever 49
lf 49


External Ids:

Disease Ontology8 DOID:9537
MeSH35 D007835
MESH via Orphanet36 D007835
ICD10 via Orphanet26 A96.2
SNOMED-CT57 19065005
SNOMED-CT via Orphanet58 19065005
UMLS via Orphanet62 C0023092
ICD1025 A96.2

Related Diseases for Lassa Fever

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Lassa Fever:



Diseases related to lassa fever

Clinical Features for Lassa Fever

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 41)
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • seizures/epilepsy/absences/spasms/status epilepticus
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • early death/lethality
  • hearing loss/hypoacusia/deafness
  • cranial hypertension
  • obnubilation/coma/lethargia/desorientation
  • asthenia/fatigue/weakness
  • fever/chilling
  • articular/joint pain/arthralgia
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • cutaneous rash
  • thoracic/chest pain
  • cough
  • myalgia/muscular pain
  • acute abdominal pain/colic
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • thrombocytopenia/thrombopenia
  • facial pain/cephalalgia/migraine
  • dizziness
  • pharyngitis
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • palpebral edema/periorbital edema
  • lymphadenopathy/polyadenopathies
  • acute diarrhea
  • leukopenia/hypoleukocytosis
  • spontaneous abortions
  • conjunctival injection/chemosis/red eye
  • fever
  • conjunctivitis
  • abdominal pain
  • diarrhea
  • vomiting
  • sore throat
  • back pain
  • retrosternal pain
  • facial swelling
  • proteinuria (protein in the urine)
  • mucosal bleeding

Drugs & Therapeutics for Lassa Fever

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lassa Fever

Drug clinical trials:

Search ClinicalTrials for Lassa Fever

Search NIH Clinical Center for Lassa Fever

Search CenterWatch for Lassa Fever

Genetic Tests for Lassa Fever

Anatomical Context for Lassa Fever

Sources:
33MalaCards
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MalaCards organs/tissues related to Lassa Fever:

33
Lung, T cells, Fetal lung

Animal Models for Lassa Fever or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Lassa Fever

Sources:
51PubMed
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Articles related to Lassa Fever:

(show top 50)    (show all 237)
idTitleAuthorsYear
1
Guidance for contact tracing of cases of Lassa fever, Ebola or Marburg haemorrhagic fever on an airplane: results of a European expert consultation. (23170851)
2012
2
Lassa fever: the challenges of curtailing a deadly disease. (22593791)
2012
3
Pathogenesis of Lassa fever in cynomolgus macaques. (21548931)
2011
4
Yellow fever 17D-vectored vaccines expressing Lassa virus GP1 and GP2 glycoproteins provide protection against fatal disease in guinea pigs. (21145373)
2011
5
Early-onset sensorineural hearing loss in Lassa fever. (20809263)
2011
6
The first case of Lassa fever imported from Mali to the United Kingdom, February 2009. (19317988)
2009
7
Early blood profiles of virus infection in a monkey model for Lassa fever. (17522210)
2007
8
Clinical laboratory, virologic, and pathologic changes in hamsters experimentally infected with Pirital virus (Arenaviridae): a rodent model of Lassa fever. (16760527)
2006
9
Lassa fever, Nigeria, 2003 and 2004. (16355508)
2005
10
Development of a new vaccine for the prevention of Lassa fever. (15971954)
2005
11
On the front lines of Lassa fever. (15586983)
2004
12
Lassa fever: epidemiology, clinical features, and social consequences. (14644972)
2003
13
Lassa fever. (11987809)
2002
14
Lassa fever encephalopathy: Lassa virus in cerebrospinal fluid but not in serum. (11443561)
2001
15
Lassa fever in Guinea: I. Epidemiology of human disease and clinical observations. (12653127)
2001
16
Lassa fever is unheralded problem in West Africa. (11479607)
2001
17
Effective vaccine for lassa fever. (10888616)
2000
18
Lassa fever, imported case, Netherlands. (10974948)
2000
19
A welcome mat for leprosy and Lassa fever. (9874652)
1998
20
People with Lassa fever. Interview by Anne Gulland. (9188427)
1997
21
The story of Lassa fever. Part IV: The politics of research. (8429951)
1993
22
Aeromedical evacuation of patients with Lassa fever. (1930087)
1991
23
Lassa fever. (2180519)
1990
24
Lassa fever in the United States. Investigation of a case and new guidelines for management. (2215580)
1990
25
Protection of guinea pigs from Lassa fever by vaccinia virus recombinants expressing the nucleoprotein or the envelope glycoproteins of Lassa virus. (2741340)
1989
26
An imported case of Lassa fever with late appearance of polyserositis. (3171229)
1988
27
A prospective study of maternal and fetal outcome in acute Lassa fever infection during pregnancy. (3139220)
1988
28
Pediatric Lassa fever: a review of 33 Liberian cases. (3826501)
1987
29
Pathophysiology and treatment of Lassa fever. (3581898)
1987
30
Endemic Lassa fever in Liberia. IV. Selection of optimally effective plasma for treatment by passive immunization. (3898484)
1985
31
Endemic Lassa fever in Liberia. III. Characterization of Lassa virus isolates. (3898483)
1985
32
Safe intensive-care management of a severe case of Lassa fever with simple barrier nursing techniques. (2866301)
1985
33
Managing Lassa fever. (6148643)
1984
34
Endemic Lassa fever in Liberia. VI. Village serological surveys for evidence of Lassa virus activity in Lofa County, Liberia. (6398530)
1984
35
Endemic Lassa fever in Liberia. I. Clinical and epidemiological aspects at Curran Lutheran Hospital, Zorzor, Liberia. (6485062)
1984
36
Endemic Lassa fever in Liberia. V. Distribution of Lassa virus activity in Liberia: hospital staff surveys. (6398529)
1984
37
Lung uptake of Tc-99m-tin colloid in a patient with Lassa fever. (6875688)
1983
38
Epidemiological aspect of the 1976 Pankshin Lassa fever outbreak. (463336)
1979
39
Experimental Lassa fever virus infection successfully treated with ribavirin. (84919)
1979
40
Lassa fever, Marburg and Ebola virus diseases and other exotic diseases: is there a risk to Canada? (570088)
1979
41
Lassa fever--an autopsy report from the eastern part of Nigeria. (702621)
1978
42
Pathobiology of Lassa fever. (350792)
1978
43
Lassa fever. (1264786)
1976
44
Lassa fever. (1016393)
1976
45
Indirect immunofluorescence for the diagnosis of Lassa fever infection. (821624)
1975
46
Hoosiers abroad--report of a case of Lassa fever. (4604539)
1974
47
Lassa fever in the Eastern Province of Sierra Leone, 1970-1972. II. Clinical observations and virological studies on selected hospital cases. (4429183)
1974
48
Lassa fever. A study of 23 hospital cases. (5046379)
1972
49
An outbreak of Lassa fever on the Jos plateau, Nigeria, in January-February 1970. A preliminary report. (4987549)
1970
50
Lassa fever, a new virus disease of man from West Africa. II. Report of a laboratory-acquired infection treated with plasma from a person recently recovered from the disease. (4987546)
1970

Genetic Variations for Lassa Fever

Expression for genes affiliated with Lassa Fever

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lassa Fever

Search GEO for disease gene expression data for Lassa Fever.

Pathways for genes affiliated with Lassa Fever

Compounds for genes affiliated with Lassa Fever

GO Terms for genes affiliated with Lassa Fever

Sources:
16Gene Ontology
See all sources

Cellular components related to Lassa Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi stackGO:0057959.2TMBIM4, MBTPS1
2Golgi membraneGO:0001399.2TMBIM4, GYLTL1B, MBTPS1

Biological processes related to Lassa Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum unfolded protein responseGO:0309689.6MBTPS1, IFNG

Products for genes affiliated with Lassa Fever

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lassa Fever

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet