MCID: LSS003
MIFTS: 38

Lassa Fever malady

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Lassa Fever

About this section
Sources:
2CDC, 11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 39MeSH, 40MESH via Orphanet, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Lassa Fever:

Name: Lassa Fever 11 54 50 2 39 13 68
Lassa Hemorrhagic Fever 54
 
Lf 54

Characteristics:

Orphanet epidemiological data:

54
lassa fever:
Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology11 DOID:9537
ICD1030 A96.2
MeSH39 D007835
Orphanet54 ORPHA99824
SNOMED-CT62 19065005
MESH via Orphanet40 D007835
UMLS via Orphanet69 C0023092
ICD10 via Orphanet31 A96.2

Summaries for Lassa Fever

About this section
Disease Ontology:11 A viral infectious disease that results in infection, has material basis in Lassa virus, which is transmitted by multimammate rat of the genus Mastomys. The infection has symptom fever, has symptom retrosternal pain, has symptom sore throat, has symptom back pain, has symptom cough, has symptom abdominal pain, has symptom vomiting, has symptom diarrhea, has symptom conjunctivitis, has symptom facial swelling, has symptom proteinuria (protein in the urine), and has symptom mucosal bleeding.

MalaCards based summary: Lassa Fever, also known as lassa hemorrhagic fever, is related to hemorrhagic fever and vaccinia, and has symptoms including abnormality of the menstrual cycle, abnormality of temperature regulation and spontaneous abortion. An important gene associated with Lassa Fever is DAG1 (Dystroglycan 1). Affiliated tissues include skin, testes and t cells.

Wikipedia:71 Lassa fever, also known as Lassa hemorrhagic fever (LHF), is a type of viral hemorrhagic fever caused by... more...

Related Diseases for Lassa Fever

About this section

Diseases related to Lassa Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
idRelated DiseaseScoreTop Affiliating Genes
1hemorrhagic fever11.4
2vaccinia10.0
3encephalopathy10.0
4sacral spinal canal and spinal cord meningioma10.0CD40LG, DAG1
5sensorineural hearing loss9.9
6lymphocytic choriomeningitis9.9
7leprosy9.8
8hepatitis9.8
9hepatitis a9.8
10rift valley fever9.8
11smallpox9.8
12stomatitis9.8
13yellow fever9.8
14viral hemorrhagic fever9.8
15secretory diarrhea9.5AXL, CD40LG
16aseptic meningitis9.4AXL, DAG1
17osteosclerotic myeloma7.7ABCB6, AXL, CD40LG, DAG1, GP2, PIGC

Graphical network of diseases related to Lassa Fever:



Diseases related to lassa fever

Symptoms & Phenotypes for Lassa Fever

About this section

Symptoms:

 11 (show all 12)
  • fever
  • retrosternal pain
  • sore throat
  • back pain
  • cough
  • abdominal pain
  • vomiting
  • diarrhea
  • conjunctivitis
  • facial swelling
  • proteinuria (protein in the urine)
  • mucosal bleeding

Human phenotypes related to Lassa Fever:

 64 54 (show all 36)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the menstrual cycle64 hallmark (90%) HP:0000140
2 abnormality of temperature regulation64 hallmark (90%) HP:0004370
3 spontaneous abortion64 54 hallmark (90%) Very frequent (99-80%) HP:0005268
4 conjunctivitis64 54 typical (50%) Frequent (79-30%) HP:0000509
5 thrombocytopenia64 54 typical (50%) Frequent (79-30%) HP:0001873
6 leukopenia64 54 typical (50%) Frequent (79-30%) HP:0001882
7 diarrhea64 54 typical (50%) Frequent (79-30%) HP:0002014
8 nausea and vomiting64 54 typical (50%) Frequent (79-30%) HP:0002017
9 abdominal pain64 54 typical (50%) Frequent (79-30%) HP:0002027
10 migraine64 typical (50%) HP:0002076
11 vertigo64 54 typical (50%) Frequent (79-30%) HP:0002321
12 arthralgia64 54 typical (50%) Frequent (79-30%) HP:0002829
13 myalgia64 54 typical (50%) Frequent (79-30%) HP:0003326
14 periorbital edema64 typical (50%) HP:0100539
15 chest pain64 54 typical (50%) Frequent (79-30%) HP:0100749
16 recurrent pharyngitis64 54 typical (50%) Frequent (79-30%) HP:0100776
17 hearing impairment64 54 occasional (7.5%) Occasional (29-5%) HP:0000365
18 skin rash64 54 occasional (7.5%) Occasional (29-5%) HP:0000988
19 seizures64 54 occasional (7.5%) Occasional (29-5%) HP:0001250
20 sudden cardiac death64 occasional (7.5%) HP:0001645
21 abnormality of the pleura64 occasional (7.5%) HP:0002103
22 gastrointestinal hemorrhage64 54 occasional (7.5%) Occasional (29-5%) HP:0002239
23 increased intracranial pressure64 54 occasional (7.5%) Occasional (29-5%) HP:0002516
24 lymphadenopathy64 54 occasional (7.5%) Occasional (29-5%) HP:0002716
25 reduced consciousness/confusion64 occasional (7.5%) HP:0004372
26 lethargy54 Occasional (29-5%)
27 subcutaneous nodule54 Frequent (79-30%)
28 fever54 Very frequent (99-80%)
29 pleural effusion54 Occasional (29-5%)
30 headache54 Frequent (79-30%)
31 cardiorespiratory arrest54 Occasional (29-5%)
32 chemosis54 Frequent (79-30%)
33 fatigue54 Very frequent (99-80%)
34 cough54 Frequent (79-30%)
35 palpebral edema54 Frequent (79-30%)
36 menometrorrhagia54 Very frequent (99-80%)

UMLS symptoms related to Lassa Fever:


hemoptysis, cullen's sign, traumatic hematuria, mucosal haemorrhage, nail bed hemorrhage

Drugs & Therapeutics for Lassa Fever

About this section

Drugs for Lassa Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RibavirinapprovedPhase 298436791-04-537542
Synonyms:
1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide
36791-04-5
437710-49-1
66510-90-5
AA-504/07617051
AB00430481
AC1L1XXZ
AC1Q1IDC
AC1Q4ZGS
AKOS001715163
BB_NC-0567
BPBio1_001195
BRN 0892462
BSPBio_001085
BSPBio_003352
C-Virin
CHEMBL1643
CID37542
Copegus
Copegus (TN)
Cotronak
D00423
DB00811
DRG-0028
DivK1c_000782
Drug: Ribavirin
EU-0101063
FT-0082885
HMS2090L15
HMS2094O09
HMS502H04
HSDB 6513
ICN-1229
IDI1_000782
KBio1_000782
KBio2_002328
KBio2_004896
KBio2_007464
KBio3_002854
KBioGR_001804
KBioSS_002331
KS-1104
LS-1241
Lopac0_001063
MLS000028486
MLS002222317
MolPort-002-507-104
MolPort-002-885-856
NCGC00090726-01
NCGC00090726-03
NCGC00090726-04
NCGC00090726-05
NCGC00090726-06
NCGC00090726-07
NINDS_000782
NSC 163039
 
NSC163039
Prestwick3_000993
R 9644
R-964
R9644_SIGMA
RBV
RG-964
RIBAV
RTC
RTCA
RTP
Ravanex
Rebetol
Rebetol (TN)
Rebetron
Rebretron
Ribacine
Ribamide
Ribamidil
Ribamidyl
Ribasphere
Ribasphere (TN)
Ribav
Ribavirin
Ribavirin (JAN/USP/INN)
Ribavirin Capsules
Ribavirin Triphosphate
Ribavirin [USAN:INN]
Ribavirin-TP
Ribavirina
Ribavirina [INN-Spanish]
Ribavirine
Ribavirine [INN-French]
Ribavirinum
Ribavirinum [INN-Latin]
Ribovirin
Ro 20-9963/000
Ro-20-9963
S2504_Selleck
SCH 18908
SMP1_000261
SMR000058315
SPECTRUM1503938
SR-01000076112-3
Spectrum3_001876
Spectrum4_001252
Spectrum5_002075
Spectrum_001826
Tribavirin
UNII-49717AWG6K
Varazid
Vilona
Viramid
Viramide
Virazid
Virazide
Virazole
Virazole (Ribavirin) Inhalation Solution
Virazole (TN)
Virazole 5'-triphosphate
ZINC01035331
ribavirin
2Antiviral AgentsPhase 29732
3AntimetabolitesPhase 211774
4Anti-Infective AgentsPhase 221402

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment FacilitiesEnrolling by invitationNCT00992693Phase 2
2Seroprevalence and Incidence of Lassa Fever in the Rural Commune of Sibirila, District of Bougouni, MaliCompletedNCT02311387
3Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic FeverNot yet recruitingNCT02483260

Search NIH Clinical Center for Lassa Fever


Cochrane evidence based reviews: lassa fever

Genetic Tests for Lassa Fever

About this section

Anatomical Context for Lassa Fever

About this section

MalaCards organs/tissues related to Lassa Fever:

36
Skin, Testes, T cells, Neutrophil, Lung

Publications for Lassa Fever

About this section

Articles related to Lassa Fever:

(show top 50)    (show all 263)
idTitleAuthorsYear
1
Chimeric Mice with Competent Hematopoietic Immunity Reproduce Key Features of Severe Lassa Fever. (27191716)
2016
2
As Ebola winds down, Lassa Fever reemerges yet again in West Africa. (26927465)
2016
3
Lassa Fever in Pregnancy: Report of 2 Cases Seen at the University College Hospital, Ibadan. (27051545)
2016
4
Postexposure prophylaxis for Lassa fever: Experience from a recent outbreak in Nigeria. (27630390)
2016
5
Lassa fever. (27333233)
2016
6
Imported Case of Lassa Fever in Sweden With Encephalopathy and Sensorineural Hearing Deficit. (27975074)
2016
7
Outbreak of lassa fever in Nigeria: measures for prevention and control. (27347299)
2016
8
Vaccine platforms to control Lassa fever. (27136941)
2016
9
An Outbreak of Ebola Virus Disease in the Lassa Fever Zone. (27402779)
2016
10
Rat-atouille: A Mixed Method Study to Characterize Rodent Hunting and Consumption in the Context of Lassa Fever. (26895631)
2016
11
Epidemic focus: Lassa Fever. (27236868)
2016
12
Imported Lassa fever: a report of 2 cases in Ghana. (26022703)
2015
13
Development of a time-trend model for analyzing and predicting case-pattern of Lassa fever epidemics in Liberia, 2013-2017. (25693816)
2015
14
Mapping the zoonotic niche of Lassa fever in Africa. (26085474)
2015
15
A Recombinant Vesicular Stomatitis Virus-Based Lassa Fever Vaccine Protects Guinea Pigs and Macaques against Challenge with Geographically and Genetically Distinct Lassa Viruses. (25884628)
2015
16
Efficacy of favipiravir alone and in combination with ribavirin in a lethal, immunocompetent mouse model for Lassa fever. (26531247)
2015
17
Engaging Market Traders in Lassa Fever Campaign: Assessment of Knowledge and Risk Behaviour. (27492545)
2015
18
Lassa fever or lassa hemorrhagic fever risk to humans from rodent-borne zoonoses. (26012219)
2015
19
Knowledge of Secondary School Children in Edo State on Lassa Fever and its Implications for Prevention and Control. (27492547)
2015
20
Using modelling to disentangle the relative contributions of zoonotic and anthroponotic transmission: the case of lassa fever. (25569707)
2015
21
Mapping of Lassa fever cases in post-conflict Liberia, 2008-2012: a descriptive and categorical analysis of age, gender and seasonal pattern. (25693822)
2015
22
Lessons learnt from the management of a case of Lassa fever and follow-up of nosocomial primary contacts in Nigeria during Ebola virus disease outbreak in West Africa. (26171669)
2015
23
After the a89blood diamonda89 conflict: lassa fever in Sierra Leone. (25574547)
2014
24
Lassa fever in post-conflict sierra leone. (24651047)
2014
25
Hyperglycemic crisis precipitated by Lassa fever in a patient with previously undiagnosed type 2 diabetes mellitus. (25244282)
2014
26
Production of CXC and CC Chemokines by Human Antigen-Presenting Cells in Response to Lassa Virus or Closely Related Immunogenic Viruses, and in Cynomolgus Monkeys with Lassa Fever. (24421914)
2014
27
Lassa fever - full recovery without ribavarin treatment: a case report. (25834520)
2014
28
Mapping transmission risk of Lassa fever in West Africa: the importance of quality control, sampling bias, and error weighting. (25105746)
2014
29
Acute abdominal pain in patients with lassa fever: Radiological assessment and diagnostic challenges. (25013248)
2014
30
Constraints in the diagnosis and treatment of Lassa Fever and the effect on mortality in hospitalized children and women with obstetric conditions in a rural district hospital in Sierra Leone. (24535150)
2014
31
Diagnostic proficiency and reporting of Lassa fever by physicians in Osun State of Nigeria. (24950705)
2014
32
The rubber plantation environment and Lassa fever epidemics in Liberia, 2008-2012: a spatial regression. (25457605)
2014
33
VaxCelerate II: rapid development of a self-assembling vaccine for Lassa fever. (25483693)
2014
34
Containing a Lassa fever epidemic in a resource-limited setting: outbreak description and lessons learned from Abakaliki, Nigeria (January-March 2012). (23871405)
2013
35
Housing equity for health equity: a rights-based approach to the control of Lassa fever in post-war Sierra Leone. (23282054)
2013
36
Lassa fever presenting as acute abdomen: a case series. (23597024)
2013
37
A historical look at the first reported cases of Lassa fever: IgG antibodies 40 years after acute infection. (23390223)
2013
38
Pathogenesis of Lassa fever virus infection: I. Susceptibility of mice to recombinant Lassa Gp/LCMV chimeric virus. (23684417)
2013
39
The search for animal models for Lassa fever vaccine development. (23256740)
2013
40
Guidance for contact tracing of cases of Lassa fever, Ebola or Marburg haemorrhagic fever on an airplane: results of a European expert consultation. (23170851)
2012
41
Hospital-based surveillance for Lassa fever in Edo State, Nigeria, 2005-2008. (22594713)
2012
42
Aeromedical evacuation using an aircraft transit isolator of a patient with Lassa fever. (22606871)
2012
43
Lassa fever in West Africa: evidence for an expanded region of endemicity. (22958249)
2012
44
Advanced vaccine candidates for Lassa fever. (23202493)
2012
45
Pathogenesis of Lassa fever. (23202452)
2012
46
Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever. (22312054)
2012
47
A Historical Look at the First Reported Cases of Lassa Fever: IgG Antibodies 40 Years After Acute Infection. (23277481)
2012
48
Lassa fever: the challenges of curtailing a deadly disease. (22593791)
2012
49
The first cases of Lassa fever in Ghana. (23661832)
2012
50
The sensitivity and specificity of Lassa virus IgM by ELISA as screening tool at early phase of Lassa fever infection. (23661877)
2012

Variations for Lassa Fever

About this section

Expression for genes affiliated with Lassa Fever

About this section
Search GEO for disease gene expression data for Lassa Fever.

Pathways for genes affiliated with Lassa Fever

About this section

GO Terms for genes affiliated with Lassa Fever

About this section

Biological processes related to Lassa Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet activationGO:00301689.9AXL, CD40LG
2viral entry into host cellGO:00467189.5AXL, DAG1
3negative regulation of apoptotic processGO:00430669.5AXL, CD40LG, TMBIM4

Molecular functions related to Lassa Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1virus receptor activityGO:00016189.5AXL, DAG1

Sources for Lassa Fever

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet