LF
MCID: LSS003
MIFTS: 40

Lassa Fever (LF) malady

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Lassa Fever

Aliases & Descriptions for Lassa Fever:

Name: Lassa Fever 12 56 52 3 42 14 69
Lassa Hemorrhagic Fever 56
Lf 56

Characteristics:

Orphanet epidemiological data:

56
lassa fever
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9537
ICD10 33 A96.2
MeSH 42 D007835
SNOMED-CT 64 19065005
Orphanet 56 ORPHA99824
MESH via Orphanet 43 D007835
UMLS via Orphanet 70 C0023092
ICD10 via Orphanet 34 A96.2
UMLS 69 C0023092

Summaries for Lassa Fever

CDC : 3 Lassa fever is endemic in parts of west Africa including Sierra Leone, Liberia, Guinea and Nigeria; however, other neighboring countries are also at risk, as the animal vector for Lassa virus, the "multimammate rat" (Mastomys natalensis) is distributed throughout the region. In 2009, the first case from Mali was reported in a traveler living in southern Mali; Ghana reported its first cases in late 2011. Isolated cases have also been reported in Côte d’Ivoire and Burkina Faso and there is serologic evidence of Lassa virus infection in Togo and Benin.

MalaCards based summary : Lassa Fever, also known as lassa hemorrhagic fever, is related to hemorrhagic fever and microscopic breast papilloma, and has symptoms including fever, retrosternal pain and sore throat. An important gene associated with Lassa Fever is DAG1 (Dystroglycan 1), and among its related pathways/superpathways is Post-translational modification- synthesis of GPI-anchored proteins. The drugs Ribavirin and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells.

Disease Ontology : 12 A viral infectious disease that results_in infection, has material basis in Lassa virus, which is transmitted_by multimammate rat of the genus Mastomys. The infection has symptom fever, has symptom retrosternal pain, has symptom sore throat, has symptom back pain, has symptom cough, has symptom abdominal pain, has symptom vomiting, has symptom diarrhea, has symptom conjunctivitis, has symptom facial swelling, has symptom proteinuria (protein in the urine), and has symptom mucosal bleeding.

Wikipedia : 71 Lassa fever, also known as Lassa hemorrhagic fever (LHF), is a type of viral hemorrhagic fever caused by... more...

Related Diseases for Lassa Fever

Diseases related to Lassa Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
id Related Disease Score Top Affiliating Genes
1 hemorrhagic fever 11.4
2 microscopic breast papilloma 10.0 CD40LG DAG1
3 encephalopathy 10.0
4 vaccinia 10.0
5 sensorineural hearing loss 9.9
6 lymphocytic choriomeningitis 9.9
7 peripheral retinal degeneration 9.9 AXL DAG1
8 viral hemorrhagic fever 9.8
9 leprosy 9.8
10 hepatitis 9.8
11 mucositis 9.8
12 hepatitis a 9.8
13 rift valley fever 9.8
14 smallpox 9.8
15 stomatitis 9.8
16 yellow fever 9.8
17 osmotic diarrhea 9.7 AXL CD40LG
18 nasopharyngeal disease 8.8 ABCB6 AXL CD40LG CH25H DAG1 GP2

Graphical network of the top 20 diseases related to Lassa Fever:



Diseases related to Lassa Fever

Symptoms & Phenotypes for Lassa Fever

Symptoms:

12 (show all 12)
  • fever
  • retrosternal pain
  • sore throat
  • back pain
  • cough
  • abdominal pain
  • vomiting
  • diarrhea
  • conjunctivitis
  • facial swelling
  • proteinuria (protein in the urine)
  • mucosal bleeding

Human phenotypes related to Lassa Fever:

56 32 (show all 29)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthralgia 56 32 Frequent (79-30%) HP:0002829
2 fatigue 56 32 Very frequent (99-80%) HP:0012378
3 myalgia 56 32 Frequent (79-30%) HP:0003326
4 fever 56 32 Very frequent (99-80%) HP:0001945
5 headache 56 32 Frequent (79-30%) HP:0002315
6 seizures 56 32 Occasional (29-5%) HP:0001250
7 vertigo 56 32 Frequent (79-30%) HP:0002321
8 chest pain 56 32 Frequent (79-30%) HP:0100749
9 abdominal pain 56 32 Frequent (79-30%) HP:0002027
10 diarrhea 56 32 Frequent (79-30%) HP:0002014
11 nausea and vomiting 56 32 Frequent (79-30%) HP:0002017
12 lethargy 56 32 Occasional (29-5%) HP:0001254
13 recurrent pharyngitis 56 32 Frequent (79-30%) HP:0100776
14 menometrorrhagia 56 32 Very frequent (99-80%) HP:0400008
15 hearing impairment 56 32 Occasional (29-5%) HP:0000365
16 increased intracranial pressure 56 32 Occasional (29-5%) HP:0002516
17 subcutaneous nodule 56 32 Frequent (79-30%) HP:0001482
18 thrombocytopenia 56 32 Frequent (79-30%) HP:0001873
19 palpebral edema 56 32 Frequent (79-30%) HP:0100540
20 chemosis 56 32 Frequent (79-30%) HP:0012375
21 gastrointestinal hemorrhage 56 32 Occasional (29-5%) HP:0002239
22 conjunctivitis 56 32 Frequent (79-30%) HP:0000509
23 skin rash 56 32 Occasional (29-5%) HP:0000988
24 cough 56 32 Frequent (79-30%) HP:0012735
25 lymphadenopathy 56 32 Occasional (29-5%) HP:0002716
26 pleural effusion 56 32 Occasional (29-5%) HP:0002202
27 leukopenia 56 32 Frequent (79-30%) HP:0001882
28 spontaneous abortion 56 32 Very frequent (99-80%) HP:0005268
29 cardiorespiratory arrest 56 32 Occasional (29-5%) HP:0006543

Drugs & Therapeutics for Lassa Fever

Drugs for Lassa Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 2 36791-04-5 37542
2 Anti-Infective Agents Phase 2
3 Antimetabolites Phase 2
4 Antiviral Agents Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment Facilities Enrolling by invitation NCT00992693 Phase 2
2 Seroprevalence and Incidence of Lassa Fever in the Rural Commune of Sibirila, District of Bougouni, Mali Completed NCT02311387
3 Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic Fever Enrolling by invitation NCT02483260

Search NIH Clinical Center for Lassa Fever

Cochrane evidence based reviews: lassa fever

Genetic Tests for Lassa Fever

Anatomical Context for Lassa Fever

MalaCards organs/tissues related to Lassa Fever:

39
Skin, Testes, T Cells, Lung, Neutrophil

Publications for Lassa Fever

Articles related to Lassa Fever:

(show top 50) (show all 263)
id Title Authors Year
1
As Ebola winds down, Lassa Fever reemerges yet again in West Africa. ( 26927465 )
2016
2
An Outbreak of Ebola Virus Disease in the Lassa Fever Zone. ( 27402779 )
2016
3
Epidemic focus: Lassa Fever. ( 27236868 )
2016
4
Outbreak of lassa fever in Nigeria: measures for prevention and control. ( 27347299 )
2016
5
Vaccine platforms to control Lassa fever. ( 27136941 )
2016
6
Imported Case of Lassa Fever in Sweden With Encephalopathy and Sensorineural Hearing Deficit. ( 27975074 )
2016
7
Lassa fever. ( 27333233 )
2016
8
Postexposure prophylaxis for Lassa fever: Experience from a recent outbreak in Nigeria. ( 27630390 )
2016
9
Chimeric Mice with Competent Hematopoietic Immunity Reproduce Key Features of Severe Lassa Fever. ( 27191716 )
2016
10
Lassa Fever in Pregnancy: Report of 2 Cases Seen at the University College Hospital, Ibadan. ( 27051545 )
2016
11
Rat-atouille: A Mixed Method Study to Characterize Rodent Hunting and Consumption in the Context of Lassa Fever. ( 26895631 )
2016
12
Mapping the zoonotic niche of Lassa fever in Africa. ( 26085474 )
2015
13
Efficacy of favipiravir alone and in combination with ribavirin in a lethal, immunocompetent mouse model for Lassa fever. ( 26531247 )
2015
14
Development of a time-trend model for analyzing and predicting case-pattern of Lassa fever epidemics in Liberia, 2013-2017. ( 25693816 )
2015
15
Lessons learnt from the management of a case of Lassa fever and follow-up of nosocomial primary contacts in Nigeria during Ebola virus disease outbreak in West Africa. ( 26171669 )
2015
16
A Recombinant Vesicular Stomatitis Virus-Based Lassa Fever Vaccine Protects Guinea Pigs and Macaques against Challenge with Geographically and Genetically Distinct Lassa Viruses. ( 25884628 )
2015
17
Lassa fever or lassa hemorrhagic fever risk to humans from rodent-borne zoonoses. ( 26012219 )
2015
18
Imported Lassa fever: a report of 2 cases in Ghana. ( 26022703 )
2015
19
Knowledge of Secondary School Children in Edo State on Lassa Fever and its Implications for Prevention and Control. ( 27492547 )
2015
20
Mapping of Lassa fever cases in post-conflict Liberia, 2008-2012: a descriptive and categorical analysis of age, gender and seasonal pattern. ( 25693822 )
2015
21
Engaging Market Traders in Lassa Fever Campaign: Assessment of Knowledge and Risk Behaviour. ( 27492545 )
2015
22
Using modelling to disentangle the relative contributions of zoonotic and anthroponotic transmission: the case of lassa fever. ( 25569707 )
2015
23
Acute abdominal pain in patients with lassa fever: Radiological assessment and diagnostic challenges. ( 25013248 )
2014
24
The rubber plantation environment and Lassa fever epidemics in Liberia, 2008-2012: a spatial regression. ( 25457605 )
2014
25
VaxCelerate II: rapid development of a self-assembling vaccine for Lassa fever. ( 25483693 )
2014
26
Diagnostic proficiency and reporting of Lassa fever by physicians in Osun State of Nigeria. ( 24950705 )
2014
27
Hyperglycemic crisis precipitated by Lassa fever in a patient with previously undiagnosed type 2 diabetes mellitus. ( 25244282 )
2014
28
Lassa fever in post-conflict sierra leone. ( 24651047 )
2014
29
Lassa fever - full recovery without ribavarin treatment: a case report. ( 25834520 )
2014
30
Production of CXC and CC Chemokines by Human Antigen-Presenting Cells in Response to Lassa Virus or Closely Related Immunogenic Viruses, and in Cynomolgus Monkeys with Lassa Fever. ( 24421914 )
2014
31
Constraints in the diagnosis and treatment of Lassa Fever and the effect on mortality in hospitalized children and women with obstetric conditions in a rural district hospital in Sierra Leone. ( 24535150 )
2014
32
After the a89blood diamonda89 conflict: lassa fever in Sierra Leone. ( 25574547 )
2014
33
Mapping transmission risk of Lassa fever in West Africa: the importance of quality control, sampling bias, and error weighting. ( 25105746 )
2014
34
Housing equity for health equity: a rights-based approach to the control of Lassa fever in post-war Sierra Leone. ( 23282054 )
2013
35
Pathogenesis of Lassa fever virus infection: I. Susceptibility of mice to recombinant Lassa Gp/LCMV chimeric virus. ( 23684417 )
2013
36
Lassa fever presenting as acute abdomen: a case series. ( 23597024 )
2013
37
Containing a Lassa fever epidemic in a resource-limited setting: outbreak description and lessons learned from Abakaliki, Nigeria (January-March 2012). ( 23871405 )
2013
38
The search for animal models for Lassa fever vaccine development. ( 23256740 )
2013
39
A historical look at the first reported cases of Lassa fever: IgG antibodies 40 years after acute infection. ( 23390223 )
2013
40
Advanced vaccine candidates for Lassa fever. ( 23202493 )
2012
41
Hospital-based surveillance for Lassa fever in Edo State, Nigeria, 2005-2008. ( 22594713 )
2012
42
Guidance for contact tracing of cases of Lassa fever, Ebola or Marburg haemorrhagic fever on an airplane: results of a European expert consultation. ( 23170851 )
2012
43
A Historical Look at the First Reported Cases of Lassa Fever: IgG Antibodies 40 Years After Acute Infection. ( 23277481 )
2012
44
Lassa fever: the challenges of curtailing a deadly disease. ( 22593791 )
2012
45
Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever. ( 22312054 )
2012
46
Aeromedical evacuation using an aircraft transit isolator of a patient with Lassa fever. ( 22606871 )
2012
47
Pathogenesis of Lassa fever. ( 23202452 )
2012
48
Lassa fever in West Africa: evidence for an expanded region of endemicity. ( 22958249 )
2012
49
Molecular diagnostics for lassa fever at Irrua specialist teaching hospital, Nigeria: lessons learnt from two years of laboratory operation. ( 23029594 )
2012
50
The first cases of Lassa fever in Ghana. ( 23661832 )
2012

Variations for Lassa Fever

Expression for Lassa Fever

Search GEO for disease gene expression data for Lassa Fever.

Pathways for Lassa Fever

Pathways related to Lassa Fever according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.62 GP2 PIGC

GO Terms for Lassa Fever

Cellular components related to Lassa Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.5 ABCB6 AXL CD40LG CH25H DAG1 PIGC
2 membrane GO:0016020 9.23 ABCB6 AXL CD40LG CH25H DAG1 GP2

Biological processes related to Lassa Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 platelet activation GO:0030168 9.16 AXL CD40LG
2 negative regulation of apoptotic process GO:0043066 9.13 AXL CD40LG TMBIM4
3 viral entry into host cell GO:0046718 8.62 AXL DAG1

Molecular functions related to Lassa Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.62 AXL DAG1

Sources for Lassa Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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