MCID: LSS003
MIFTS: 38

Lassa Fever malady

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Lassa Fever

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Sources:
2CDC, 11Disease Ontology, 13DISEASES, 29ICD10, 30ICD10 via Orphanet, 38MeSH, 39MESH via Orphanet, 49Novoseek, 53Orphanet, 61SNOMED-CT, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Lassa Fever:

Name: Lassa Fever 11 53 49 2 38 13 67
Lassa Hemorrhagic Fever 53
 
Lf 53

Characteristics:

Orphanet epidemiological data:

53
lassa fever:
Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology11 DOID:9537
ICD1029 A96.2
MeSH38 D007835
Orphanet53 ORPHA99824
SNOMED-CT61 19065005
MESH via Orphanet39 D007835
UMLS via Orphanet68 C0023092
ICD10 via Orphanet30 A96.2

Summaries for Lassa Fever

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Disease Ontology:11 A viral infectious disease that results in infection, has material basis in Lassa virus, which is transmitted by multimammate rat of the genus Mastomys. The infection has symptom fever, has symptom retrosternal pain, has symptom sore throat, has symptom back pain, has symptom cough, has symptom abdominal pain, has symptom vomiting, has symptom diarrhea, has symptom conjunctivitis, has symptom facial swelling, has symptom proteinuria (protein in the urine), and has symptom mucosal bleeding.

MalaCards based summary: Lassa Fever, also known as lassa hemorrhagic fever, is related to hemorrhagic fever and vaccinia, and has symptoms including abnormality of the menstrual cycle, abnormality of temperature regulation and spontaneous abortion. An important gene associated with Lassa Fever is DAG1 (Dystroglycan 1). Affiliated tissues include skin, testes and t cells.

Wikipedia:70 Lassa fever, also known as Lassa hemorrhagic fever (LHF), is a type of viral hemorrhagic fever caused by... more...

Related Diseases for Lassa Fever

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Diseases related to Lassa Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
idRelated DiseaseScoreTop Affiliating Genes
1hemorrhagic fever11.4
2vaccinia10.0
3encephalopathy10.0
4sacral spinal canal and spinal cord meningioma10.0CD40LG, DAG1
5sensorineural hearing loss9.9
6lymphocytic choriomeningitis9.9
7leprosy9.8
8hepatitis9.8
9hepatitis a9.8
10rift valley fever9.8
11smallpox9.8
12stomatitis9.8
13yellow fever9.8
14viral hemorrhagic fever9.8
15secretory diarrhea9.5AXL, CD40LG
16aseptic meningitis9.4AXL, DAG1
17osteosclerotic myeloma7.7ABCB6, AXL, CD40LG, DAG1, GP2, PIGC

Graphical network of diseases related to Lassa Fever:



Diseases related to lassa fever

Symptoms for Lassa Fever

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Symptoms:

 11 (show all 12)
  • fever
  • retrosternal pain
  • sore throat
  • back pain
  • cough
  • abdominal pain
  • vomiting
  • diarrhea
  • conjunctivitis
  • facial swelling
  • proteinuria (protein in the urine)
  • mucosal bleeding

Human phenotypes related to Lassa Fever:

 63 53 (show all 36)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the menstrual cycle63 hallmark (90%) HP:0000140
2 abnormality of temperature regulation63 hallmark (90%) HP:0004370
3 spontaneous abortion63 53 hallmark (90%) Very frequent (99-80%) HP:0005268
4 conjunctivitis63 53 typical (50%) Frequent (79-30%) HP:0000509
5 thrombocytopenia63 53 typical (50%) Frequent (79-30%) HP:0001873
6 leukopenia63 53 typical (50%) Frequent (79-30%) HP:0001882
7 diarrhea63 53 typical (50%) Frequent (79-30%) HP:0002014
8 nausea and vomiting63 53 typical (50%) Frequent (79-30%) HP:0002017
9 abdominal pain63 53 typical (50%) Frequent (79-30%) HP:0002027
10 migraine63 typical (50%) HP:0002076
11 vertigo63 53 typical (50%) Frequent (79-30%) HP:0002321
12 arthralgia63 53 typical (50%) Frequent (79-30%) HP:0002829
13 myalgia63 53 typical (50%) Frequent (79-30%) HP:0003326
14 periorbital edema63 typical (50%) HP:0100539
15 chest pain63 53 typical (50%) Frequent (79-30%) HP:0100749
16 recurrent pharyngitis63 53 typical (50%) Frequent (79-30%) HP:0100776
17 hearing impairment63 53 occasional (7.5%) Occasional (29-5%) HP:0000365
18 skin rash63 53 occasional (7.5%) Occasional (29-5%) HP:0000988
19 seizures63 53 occasional (7.5%) Occasional (29-5%) HP:0001250
20 sudden cardiac death63 occasional (7.5%) HP:0001645
21 abnormality of the pleura63 occasional (7.5%) HP:0002103
22 gastrointestinal hemorrhage63 53 occasional (7.5%) Occasional (29-5%) HP:0002239
23 increased intracranial pressure63 53 occasional (7.5%) Occasional (29-5%) HP:0002516
24 lymphadenopathy63 53 occasional (7.5%) Occasional (29-5%) HP:0002716
25 reduced consciousness/confusion63 occasional (7.5%) HP:0004372
26 lethargy53 Occasional (29-5%)
27 subcutaneous nodule53 Frequent (79-30%)
28 fever53 Very frequent (99-80%)
29 pleural effusion53 Occasional (29-5%)
30 headache53 Frequent (79-30%)
31 cardiorespiratory arrest53 Occasional (29-5%)
32 chemosis53 Frequent (79-30%)
33 fatigue53 Very frequent (99-80%)
34 cough53 Frequent (79-30%)
35 palpebral edema53 Frequent (79-30%)
36 menometrorrhagia53 Very frequent (99-80%)

UMLS symptoms related to Lassa Fever:


hemoptysis, cullen's sign, traumatic hematuria, mucosal haemorrhage, nail bed hemorrhage

Drugs & Therapeutics for Lassa Fever

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Drugs for Lassa Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RibavirinapprovedPhase 298436791-04-537542
Synonyms:
1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide
36791-04-5
437710-49-1
66510-90-5
AA-504/07617051
AB00430481
AC1L1XXZ
AC1Q1IDC
AC1Q4ZGS
AKOS001715163
BB_NC-0567
BPBio1_001195
BRN 0892462
BSPBio_001085
BSPBio_003352
C-Virin
CHEMBL1643
CID37542
Copegus
Copegus (TN)
Cotronak
D00423
DB00811
DRG-0028
DivK1c_000782
Drug: Ribavirin
EU-0101063
FT-0082885
HMS2090L15
HMS2094O09
HMS502H04
HSDB 6513
ICN-1229
IDI1_000782
KBio1_000782
KBio2_002328
KBio2_004896
KBio2_007464
KBio3_002854
KBioGR_001804
KBioSS_002331
KS-1104
LS-1241
Lopac0_001063
MLS000028486
MLS002222317
MolPort-002-507-104
MolPort-002-885-856
NCGC00090726-01
NCGC00090726-03
NCGC00090726-04
NCGC00090726-05
NCGC00090726-06
NCGC00090726-07
NINDS_000782
NSC 163039
 
NSC163039
Prestwick3_000993
R 9644
R-964
R9644_SIGMA
RBV
RG-964
RIBAV
RTC
RTCA
RTP
Ravanex
Rebetol
Rebetol (TN)
Rebetron
Rebretron
Ribacine
Ribamide
Ribamidil
Ribamidyl
Ribasphere
Ribasphere (TN)
Ribav
Ribavirin
Ribavirin (JAN/USP/INN)
Ribavirin Capsules
Ribavirin Triphosphate
Ribavirin [USAN:INN]
Ribavirin-TP
Ribavirina
Ribavirina [INN-Spanish]
Ribavirine
Ribavirine [INN-French]
Ribavirinum
Ribavirinum [INN-Latin]
Ribovirin
Ro 20-9963/000
Ro-20-9963
S2504_Selleck
SCH 18908
SMP1_000261
SMR000058315
SPECTRUM1503938
SR-01000076112-3
Spectrum3_001876
Spectrum4_001252
Spectrum5_002075
Spectrum_001826
Tribavirin
UNII-49717AWG6K
Varazid
Vilona
Viramid
Viramide
Virazid
Virazide
Virazole
Virazole (Ribavirin) Inhalation Solution
Virazole (TN)
Virazole 5'-triphosphate
ZINC01035331
ribavirin
2Antiviral AgentsPhase 29732
3AntimetabolitesPhase 211774
4Anti-Infective AgentsPhase 221402

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment FacilitiesEnrolling by invitationNCT00992693Phase 2
2Seroprevalence and Incidence of Lassa Fever in the Rural Commune of Sibirila, District of Bougouni, MaliCompletedNCT02311387
3Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic FeverNot yet recruitingNCT02483260

Search NIH Clinical Center for Lassa Fever


Cochrane evidence based reviews: lassa fever

Genetic Tests for Lassa Fever

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Anatomical Context for Lassa Fever

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MalaCards organs/tissues related to Lassa Fever:

35
Skin, Testes, T cells, Neutrophil, Lung

Animal Models for Lassa Fever or affiliated genes

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Publications for Lassa Fever

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Articles related to Lassa Fever:

(show top 50)    (show all 263)
idTitleAuthorsYear
1
Chimeric Mice with Competent Hematopoietic Immunity Reproduce Key Features of Severe Lassa Fever. (27191716)
2016
2
As Ebola winds down, Lassa Fever reemerges yet again in West Africa. (26927465)
2016
3
Imported Lassa fever: a report of 2 cases in Ghana. (26022703)
2015
4
Development of a time-trend model for analyzing and predicting case-pattern of Lassa fever epidemics in Liberia, 2013-2017. (25693816)
2015
5
Mapping the zoonotic niche of Lassa fever in Africa. (26085474)
2015
6
After the a89blood diamonda89 conflict: lassa fever in Sierra Leone. (25574547)
2014
7
Lassa fever in post-conflict sierra leone. (24651047)
2014
8
Hyperglycemic crisis precipitated by Lassa fever in a patient with previously undiagnosed type 2 diabetes mellitus. (25244282)
2014
9
Containing a Lassa fever epidemic in a resource-limited setting: outbreak description and lessons learned from Abakaliki, Nigeria (January-March 2012). (23871405)
2013
10
Guidance for contact tracing of cases of Lassa fever, Ebola or Marburg haemorrhagic fever on an airplane: results of a European expert consultation. (23170851)
2012
11
Hospital-based surveillance for Lassa fever in Edo State, Nigeria, 2005-2008. (22594713)
2012
12
Aeromedical evacuation using an aircraft transit isolator of a patient with Lassa fever. (22606871)
2012
13
Pathogenesis of Lassa fever in cynomolgus macaques. (21548931)
2011
14
Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever. (21820469)
2011
15
Early-onset sensorineural hearing loss in Lassa fever. (20809263)
2011
16
Clinical laboratory, virologic, and pathologic changes in hamsters experimentally infected with Pirital virus (Arenaviridae): a rodent model of Lassa fever. (16760527)
2006
17
Lassa fever, Nigeria, 2003 and 2004. (16355508)
2005
18
Characterization of the interaction of lassa fever virus with its cellular receptor alpha-dystroglycan. (15857984)
2005
19
The public health response to a case of Lassa fever in London in 2000. (15001300)
2004
20
On the front lines of Lassa fever. (15586983)
2004
21
Lassa fever. (11987809)
2002
22
Lassa fever. (12138522)
2002
23
Short communication: Lassa fever in Sierra Leone: UN peacekeepers are at risk. (11251899)
2001
24
Murine immune responses to mucosally delivered Salmonella expressing Lassa fever virus nucleoprotein. (10618553)
2000
25
Lassa fever imported to England. (10769487)
2000
26
People with Lassa fever. Interview by Anne Gulland. (9188427)
1997
27
Lassa fever: review of virology, immunopathogenesis, and algorithms for control and therapy. (1394407)
1992
28
Deafness associated with Lassa fever. (2214082)
1990
29
Imported Lassa fever--reexamining the algorithms. (2215584)
1990
30
Plasma from patients with severe Lassa fever profoundly modulates f-met-leu-phe induced superoxide generation in neutrophils. (2554951)
1989
31
Clinical features of Lassa fever in Liberia. (2749109)
1989
32
Use of monoclonal antibody for the detection of Lassa virus antibody and antigen in patients with Lassa fever. (3523183)
1986
33
Journal of Infection Control Nursing. Nursing the isolated patient: Lassa fever. (3640375)
1986
34
Management of Lassa fever. (2867274)
1986
35
Patients with suspected Lassa fever in London during 1984. (3080068)
1986
36
No evidence for increased risk of Lassa fever infection in hospital staff. (2877335)
1986
37
Patients with suspected Lassa fever in London during 1984. (3935259)
1985
38
The use of Lassa fever convalescent plasma in Nigeria. (6464130)
1984
39
Managing Lassa fever. (6148643)
1984
40
Endemic Lassa fever in Liberia. VI. Village serological surveys for evidence of Lassa virus activity in Lofa County, Liberia. (6398530)
1984
41
Possible approaches to a vaccine against Lassa fever. (6464128)
1984
42
Enhanced treatment of Lassa fever by immune plasma combined with ribavirin in cynomolgus monkeys. (6715898)
1984
43
Lassa fever antibodies in hospital personnel in the Plateau State of Nigeria. (463337)
1979
44
Epidemiological aspect of the 1976 Pankshin Lassa fever outbreak. (463336)
1979
45
Lassa fever (LF) and Marburg disease (MVD): occurrences, origins and diagnoses. (567823)
1978
46
Lassa fever--an autopsy report from the eastern part of Nigeria. (702621)
1978
47
The Lassa fever crisis. (832782)
1977
48
Lassa fever: response to an imported case. (895819)
1977
49
Editorial: Lassa fever. (46518)
1975
50
Hoosiers abroad--report of a case of Lassa fever. (4604539)
1974

Variations for Lassa Fever

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Expression for genes affiliated with Lassa Fever

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Search GEO for disease gene expression data for Lassa Fever.

Pathways for genes affiliated with Lassa Fever

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GO Terms for genes affiliated with Lassa Fever

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Biological processes related to Lassa Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1viral entry into host cellGO:00467189.5AXL, DAG1
2platelet activationGO:00301689.5AXL, CD40LG
3negative regulation of apoptotic processGO:00430668.6AXL, CD40LG, TMBIM4

Molecular functions related to Lassa Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1virus receptor activityGO:00016189.5AXL, DAG1

Sources for Lassa Fever

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet