MCID: LSS003
MIFTS: 41

Lassa Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Lassa Fever

Summaries for Lassa Fever

CDC : 3 Lassa fever is endemic in parts of west Africa including Sierra Leone, Liberia, Guinea and Nigeria; however, other neighboring countries are also at risk, as the animal vector for Lassa virus, the "multimammate rat" (Mastomys natalensis) is distributed throughout the region. In 2009, the first case from Mali was reported in a traveler living in southern Mali; Ghana reported its first cases in late 2011. Isolated cases have also been reported in Côte d’Ivoire and Burkina Faso and there is serologic evidence of Lassa virus infection in Togo and Benin.

MalaCards based summary : Lassa Fever, also known as lassa hemorrhagic fever, is related to hemorrhagic fever and vaccinia, and has symptoms including hearing impairment, conjunctivitis and skin rash. An important gene associated with Lassa Fever is DAG1 (Dystroglycan 1), and among its related pathways/superpathways is Post-translational modification- synthesis of GPI-anchored proteins. The drugs Ribavirin and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells, and related phenotype is Synthetic lethal with MLN4924 (a NAE inhibitor).

Disease Ontology : 12 A viral infectious disease that results_in infection, has material basis in Lassa virus, which is transmitted_by multimammate rat of the genus Mastomys. The infection has symptom fever, has symptom retrosternal pain, has symptom sore throat, has symptom back pain, has symptom cough, has symptom abdominal pain, has symptom vomiting, has symptom diarrhea, has symptom conjunctivitis, has symptom facial swelling, has symptom proteinuria (protein in the urine), and has symptom mucosal bleeding.

Wikipedia : 72 Lassa fever, also known as Lassa hemorrhagic fever (LHF), is a type of viral hemorrhagic fever caused by... more...

Related Diseases for Lassa Fever

Diseases related to Lassa Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
id Related Disease Score Top Affiliating Genes
1 hemorrhagic fever 11.4
2 vaccinia 10.0
3 encephalopathy 10.0
4 lung superior sulcus carcinoma 10.0 CD40LG DAG1
5 sensorineural hearing loss 9.9
6 lymphocytic choriomeningitis 9.9
7 peripheral retinal degeneration 9.9 AXL DAG1
8 leprosy 9.8
9 hepatitis 9.8
10 mucositis 9.8
11 hepatitis a 9.8
12 rift valley fever 9.8
13 smallpox 9.8
14 stomatitis 9.8
15 yellow fever 9.8
16 viral hemorrhagic fever 9.8
17 chronic subinvolution of uterus 9.5 CD40LG GPR132
18 secretory diarrhea 9.5 AXL CD40LG
19 refractory plasma cell neoplasm 6.8 AXL CD40LG CH25H DAG1 GP2 GPR132

Graphical network of the top 20 diseases related to Lassa Fever:



Diseases related to Lassa Fever

Symptoms & Phenotypes for Lassa Fever

Human phenotypes related to Lassa Fever:

56 32 (show all 29)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hearing impairment 56 32 occasional (7.5%) Occasional (29-5%) HP:0000365
2 conjunctivitis 56 32 frequent (33%) Frequent (79-30%) HP:0000509
3 skin rash 56 32 occasional (7.5%) Occasional (29-5%) HP:0000988
4 seizures 56 32 occasional (7.5%) Occasional (29-5%) HP:0001250
5 lethargy 56 32 occasional (7.5%) Occasional (29-5%) HP:0001254
6 subcutaneous nodule 56 32 frequent (33%) Frequent (79-30%) HP:0001482
7 thrombocytopenia 56 32 frequent (33%) Frequent (79-30%) HP:0001873
8 leukopenia 56 32 frequent (33%) Frequent (79-30%) HP:0001882
9 fever 56 32 hallmark (90%) Very frequent (99-80%) HP:0001945
10 diarrhea 56 32 frequent (33%) Frequent (79-30%) HP:0002014
11 nausea and vomiting 56 32 frequent (33%) Frequent (79-30%) HP:0002017
12 abdominal pain 56 32 frequent (33%) Frequent (79-30%) HP:0002027
13 pleural effusion 56 32 occasional (7.5%) Occasional (29-5%) HP:0002202
14 gastrointestinal hemorrhage 56 32 occasional (7.5%) Occasional (29-5%) HP:0002239
15 headache 56 32 frequent (33%) Frequent (79-30%) HP:0002315
16 vertigo 56 32 frequent (33%) Frequent (79-30%) HP:0002321
17 increased intracranial pressure 56 32 occasional (7.5%) Occasional (29-5%) HP:0002516
18 lymphadenopathy 56 32 occasional (7.5%) Occasional (29-5%) HP:0002716
19 arthralgia 56 32 frequent (33%) Frequent (79-30%) HP:0002829
20 myalgia 56 32 frequent (33%) Frequent (79-30%) HP:0003326
21 spontaneous abortion 56 32 hallmark (90%) Very frequent (99-80%) HP:0005268
22 cardiorespiratory arrest 56 32 occasional (7.5%) Occasional (29-5%) HP:0006543
23 chemosis 56 32 frequent (33%) Frequent (79-30%) HP:0012375
24 fatigue 56 32 hallmark (90%) Very frequent (99-80%) HP:0012378
25 cough 56 32 frequent (33%) Frequent (79-30%) HP:0012735
26 palpebral edema 56 32 frequent (33%) Frequent (79-30%) HP:0100540
27 chest pain 56 32 frequent (33%) Frequent (79-30%) HP:0100749
28 recurrent pharyngitis 56 32 frequent (33%) Frequent (79-30%) HP:0100776
29 menometrorrhagia 56 32 hallmark (90%) Very frequent (99-80%) HP:0400008

GenomeRNAi Phenotypes related to Lassa Fever according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 CD40LG CH25H DAG1 GPR132
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 CD40LG CH25H DAG1 GPR132

Drugs & Therapeutics for Lassa Fever

Drugs for Lassa Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 2 36791-04-5 37542
2 Anti-Infective Agents Phase 2
3 Antimetabolites Phase 2
4 Antiviral Agents Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment Facilities Enrolling by invitation NCT00992693 Phase 2 Ribavirin (Virazole) Injection
2 Seroprevalence and Incidence of Lassa Fever in the Rural Commune of Sibirila, District of Bougouni, Mali Completed NCT02311387
3 Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic Fever Enrolling by invitation NCT02483260 Ribavirin

Search NIH Clinical Center for Lassa Fever

Cochrane evidence based reviews: lassa fever

Genetic Tests for Lassa Fever

Anatomical Context for Lassa Fever

MalaCards organs/tissues related to Lassa Fever:

39
Skin, Testes, T Cells, Neutrophil, Lung

Publications for Lassa Fever

Articles related to Lassa Fever:

(show top 50) (show all 272)
id Title Authors Year
1
Moving Lassa Fever Research and Care Into the 21st Century. ( 28863471 )
2017
2
Lassa fever. ( 28701331 )
2017
3
Knowledge Attitude and Practices Toward Lassa Fever Control and Prevention Among Residents of Ile-Ife, Southwest Nigeria. ( 28511600 )
2017
4
Laboratory Diagnosis of Lassa Fever. ( 28404674 )
2017
5
Understanding the cryptic nature of Lassa fever in West Africa. ( 28875769 )
2017
6
Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever. ( 28869611 )
2017
7
Metabolomics analyses identify platelet activating factors and heme breakdown products as Lassa fever biomarkers. ( 28922385 )
2017
8
Imported Case of Lassa Fever in Sweden With Encephalopathy and Sensorineural Hearing Deficit. ( 27975074 )
2016
9
Chimeric Mice with Competent Hematopoietic Immunity Reproduce Key Features of Severe Lassa Fever. ( 27191716 )
2016
10
Molecular confirmation of Lassa fever imported into Ghana. ( 28879105 )
2016
11
As Ebola winds down, Lassa Fever reemerges yet again in West Africa. ( 26927465 )
2016
12
Rat-atouille: A Mixed Method Study to Characterize Rodent Hunting and Consumption in the Context of Lassa Fever. ( 26895631 )
2016
13
Vaccine platforms to control Lassa fever. ( 27136941 )
2016
14
Outbreak of lassa fever in Nigeria: measures for prevention and control. ( 27347299 )
2016
15
Postexposure prophylaxis for Lassa fever: Experience from a recent outbreak in Nigeria. ( 27630390 )
2016
16
Lassa fever: another threat from West Africa. ( 28265442 )
2016
17
An Outbreak of Ebola Virus Disease in the Lassa Fever Zone. ( 27402779 )
2016
18
Lassa fever. ( 27333233 )
2016
19
Epidemic focus: Lassa Fever. ( 27236868 )
2016
20
Lassa Fever in Pregnancy: Report of 2 Cases Seen at the University College Hospital, Ibadan. ( 27051545 )
2016
21
Development of a time-trend model for analyzing and predicting case-pattern of Lassa fever epidemics in Liberia, 2013-2017. ( 25693816 )
2015
22
Lessons learnt from the management of a case of Lassa fever and follow-up of nosocomial primary contacts in Nigeria during Ebola virus disease outbreak in West Africa. ( 26171669 )
2015
23
Efficacy of favipiravir alone and in combination with ribavirin in a lethal, immunocompetent mouse model for Lassa fever. ( 26531247 )
2015
24
Using modelling to disentangle the relative contributions of zoonotic and anthroponotic transmission: the case of lassa fever. ( 25569707 )
2015
25
Imported Lassa fever: a report of 2 cases in Ghana. ( 26022703 )
2015
26
A Recombinant Vesicular Stomatitis Virus-Based Lassa Fever Vaccine Protects Guinea Pigs and Macaques against Challenge with Geographically and Genetically Distinct Lassa Viruses. ( 25884628 )
2015
27
Engaging Market Traders in Lassa Fever Campaign: Assessment of Knowledge and Risk Behaviour. ( 27492545 )
2015
28
Mapping the zoonotic niche of Lassa fever in Africa. ( 26085474 )
2015
29
Mapping of Lassa fever cases in post-conflict Liberia, 2008-2012: a descriptive and categorical analysis of age, gender and seasonal pattern. ( 25693822 )
2015
30
Lassa fever or lassa hemorrhagic fever risk to humans from rodent-borne zoonoses. ( 26012219 )
2015
31
Knowledge of Secondary School Children in Edo State on Lassa Fever and its Implications for Prevention and Control. ( 27492547 )
2015
32
Acute abdominal pain in patients with lassa fever: Radiological assessment and diagnostic challenges. ( 25013248 )
2014
33
Production of CXC and CC Chemokines by Human Antigen-Presenting Cells in Response to Lassa Virus or Closely Related Immunogenic Viruses, and in Cynomolgus Monkeys with Lassa Fever. ( 24421914 )
2014
34
Lassa fever in post-conflict sierra leone. ( 24651047 )
2014
35
Constraints in the diagnosis and treatment of Lassa Fever and the effect on mortality in hospitalized children and women with obstetric conditions in a rural district hospital in Sierra Leone. ( 24535150 )
2014
36
After the a89blood diamonda89 conflict: lassa fever in Sierra Leone. ( 25574547 )
2014
37
The rubber plantation environment and Lassa fever epidemics in Liberia, 2008-2012: a spatial regression. ( 25457605 )
2014
38
VaxCelerate II: rapid development of a self-assembling vaccine for Lassa fever. ( 25483693 )
2014
39
Mapping transmission risk of Lassa fever in West Africa: the importance of quality control, sampling bias, and error weighting. ( 25105746 )
2014
40
Hyperglycemic crisis precipitated by Lassa fever in a patient with previously undiagnosed type 2 diabetes mellitus. ( 25244282 )
2014
41
Lassa fever - full recovery without ribavarin treatment: a case report. ( 25834520 )
2014
42
Diagnostic proficiency and reporting of Lassa fever by physicians in Osun State of Nigeria. ( 24950705 )
2014
43
Containing a Lassa fever epidemic in a resource-limited setting: outbreak description and lessons learned from Abakaliki, Nigeria (January-March 2012). ( 23871405 )
2013
44
Lassa fever presenting as acute abdomen: a case series. ( 23597024 )
2013
45
Housing equity for health equity: a rights-based approach to the control of Lassa fever in post-war Sierra Leone. ( 23282054 )
2013
46
Pathogenesis of Lassa fever virus infection: I. Susceptibility of mice to recombinant Lassa Gp/LCMV chimeric virus. ( 23684417 )
2013
47
A historical look at the first reported cases of Lassa fever: IgG antibodies 40 years after acute infection. ( 23390223 )
2013
48
The search for animal models for Lassa fever vaccine development. ( 23256740 )
2013
49
Aeromedical evacuation using an aircraft transit isolator of a patient with Lassa fever. ( 22606871 )
2012
50
Lassa fever in West Africa: evidence for an expanded region of endemicity. ( 22958249 )
2012

Variations for Lassa Fever

Expression for Lassa Fever

Search GEO for disease gene expression data for Lassa Fever.

Pathways for Lassa Fever

Pathways related to Lassa Fever according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.62 GP2 PIGC

GO Terms for Lassa Fever

Cellular components related to Lassa Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.5 AXL CD40LG CH25H DAG1 GPR132 PIGC
2 membrane GO:0016020 9.23 AXL CD40LG CH25H DAG1 GP2 GPR132

Biological processes related to Lassa Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 platelet activation GO:0030168 9.16 AXL CD40LG
2 negative regulation of apoptotic process GO:0043066 9.13 AXL CD40LG TMBIM4
3 viral entry into host cell GO:0046718 8.62 AXL DAG1

Molecular functions related to Lassa Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.62 AXL DAG1

Sources for Lassa Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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