MCID: LSS003
MIFTS: 39

Lassa Fever malady

Infectious diseases, Rare diseases categories

Aliases & Classifications for Lassa Fever

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Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 51Orphanet, 2CDC, 65UMLS, 36MeSH, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet, 27ICD10
See all sources

Aliases & Descriptions for Lassa Fever:

Name: Lassa Fever 10 47 12 51 2 65 36
Lassa Hemorrhagic Fever 51
 
Lf 51


Classifications:



Characteristics (Orphanet epidemiological data):

51
lassa fever:
Age of onset: All ages; Age of death: any age


External Ids:

Disease Ontology10 DOID:9537
MeSH36 D007835
Orphanet51 99824
ICD10 via Orphanet28 A96.2
SNOMED-CT59 19065005
MESH via Orphanet37 D007835
UMLS via Orphanet66 C0023092
ICD1027 A96.2

Summaries for Lassa Fever

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Disease Ontology:10 A viral infectious disease that results in infection, has material basis in lassa virus, which is transmitted by multimammate rat of the genus mastomys. the infection has symptom fever, has symptom retrosternal pain, has symptom sore throat, has symptom back pain, has symptom cough, has symptom abdominal pain, has symptom vomiting, has symptom diarrhea, has symptom conjunctivitis, has symptom facial swelling, has symptom proteinuria (protein in the urine), and has symptom mucosal bleeding.

MalaCards based summary: Lassa Fever, also known as lassa hemorrhagic fever, is related to hemorrhagic fever and vaccinia, and has symptoms including abnormality of the menstrual cycle, abnormality of temperature regulation and spontaneous abortion. An important gene associated with Lassa Fever is DAG1 (Dystroglycan 1 (Dystrophin-Associated Glycoprotein 1)). Affiliated tissues include eye, skin and testes.

Wikipedia:68 Lassa fever or Lassa hemorrhagic fever (LHF) is an acute viral hemorrhagic fever caused by the Lassa... more...

Related Diseases for Lassa Fever

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Graphical network of the top 20 diseases related to Lassa Fever:



Diseases related to lassa fever

Symptoms for Lassa Fever

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Symptoms:

 51 10 (show all 41)
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • fever/chilling
  • asthenia/fatigue/weakness
  • spontaneous abortions
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • conjunctival injection/chemosis/red eye
  • palpebral edema/periorbital edema
  • dizziness
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • pharyngitis
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • acute diarrhea
  • thoracic/chest pain
  • cough
  • facial pain/cephalalgia/migraine
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • leukopenia/hypoleukocytosis
  • thrombocytopenia/thrombopenia
  • hearing loss/hypoacusia/deafness
  • cutaneous rash
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • lymphadenopathy/polyadenopathies
  • cranial hypertension
  • seizures/epilepsy/absences/spasms/status epilepticus
  • obnubilation/coma/lethargia/desorientation
  • early death/lethality
  • fever
  • retrosternal pain
  • sore throat
  • back pain
  • abdominal pain
  • vomiting
  • diarrhea
  • conjunctivitis
  • facial swelling
  • proteinuria (protein in the urine)
  • mucosal bleeding

HPO human phenotypes related to Lassa Fever:

(show all 25)
id Description Frequency HPO Source Accession
1 abnormality of the menstrual cycle hallmark (90%) HP:0000140
2 abnormality of temperature regulation hallmark (90%) HP:0004370
3 spontaneous abortion hallmark (90%) HP:0005268
4 conjunctivitis typical (50%) HP:0000509
5 thrombocytopenia typical (50%) HP:0001873
6 leukopenia typical (50%) HP:0001882
7 diarrhea typical (50%) HP:0002014
8 nausea and vomiting typical (50%) HP:0002017
9 abdominal pain typical (50%) HP:0002027
10 migraine typical (50%) HP:0002076
11 vertigo typical (50%) HP:0002321
12 arthralgia typical (50%) HP:0002829
13 myalgia typical (50%) HP:0003326
14 periorbital edema typical (50%) HP:0100539
15 chest pain typical (50%) HP:0100749
16 recurrent pharyngitis typical (50%) HP:0100776
17 hearing impairment occasional (7.5%) HP:0000365
18 skin rash occasional (7.5%) HP:0000988
19 seizures occasional (7.5%) HP:0001250
20 sudden cardiac death occasional (7.5%) HP:0001645
21 abnormality of the pleura occasional (7.5%) HP:0002103
22 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
23 increased intracranial pressure occasional (7.5%) HP:0002516
24 lymphadenopathy occasional (7.5%) HP:0002716
25 reduced consciousness/confusion occasional (7.5%) HP:0004372

Drugs & Therapeutics for Lassa Fever

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Drugs for Lassa Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RibavirinapprovedPhase 291436791-04-537542
Synonyms:
1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide
36791-04-5
437710-49-1
66510-90-5
AA-504/07617051
AB00430481
AC1L1XXZ
AC1Q1IDC
AC1Q4ZGS
AKOS001715163
BB_NC-0567
BPBio1_001195
BRN 0892462
BSPBio_001085
BSPBio_003352
C-Virin
CHEMBL1643
CID37542
Copegus
Copegus (TN)
Cotronak
D00423
DB00811
DRG-0028
DivK1c_000782
Drug: Ribavirin
EU-0101063
FT-0082885
HMS2090L15
HMS2094O09
HMS502H04
HSDB 6513
ICN-1229
IDI1_000782
Ibavyr
KBio1_000782
KBio2_002328
KBio2_004896
KBio2_007464
KBio3_002854
KBioGR_001804
KBioSS_002331
KS-1104
LS-1241
Lopac0_001063
MLS000028486
MLS002222317
Moderiba
MolPort-002-507-104
MolPort-002-885-856
NCGC00090726-01
NCGC00090726-03
NCGC00090726-04
NCGC00090726-05
NCGC00090726-06
NCGC00090726-07
NINDS_000782
 
NSC 163039
NSC163039
Prestwick3_000993
R 9644
R-964
R9644_SIGMA
RBV
RG-964
RIBAV
RTC
RTCA
RTP
Ravanex
Rebetol
Rebetol (TN)
Rebetron
Rebretron
Ribacine
Ribamide
Ribamidil
Ribamidyl
Ribasphere
Ribasphere (TN)
Ribasphere Ribapak
Ribav
Ribavirin
Ribavirin (JAN/USP/INN)
Ribavirin Capsules
Ribavirin Triphosphate
Ribavirin [USAN:INN]
Ribavirin-TP
Ribavirina
Ribavirina [INN-Spanish]
Ribavirine
Ribavirine [INN-French]
Ribavirinum
Ribavirinum [INN-Latin]
Ribovirin
Ro 20-9963/000
Ro-20-9963
S2504_Selleck
SCH 18908
SMP1_000261
SMR000058315
SPECTRUM1503938
SR-01000076112-3
Spectrum3_001876
Spectrum4_001252
Spectrum5_002075
Spectrum_001826
Tribavirin
UNII-49717AWG6K
Varazid
Vilona
Viramid
Viramide
Virazid
Virazide
Virazole
Virazole (Ribavirin) Inhalation Solution
Virazole (TN)
Virazole 5'-triphosphate
ZINC01035331
ribavirin

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment FacilitiesEnrolling by invitationNCT00992693Phase 2
2Seroprevalence and Incidence of Lassa Fever in the Rural Commune of Sibirila, District of Bougouni, MaliActive, not recruitingNCT02311387
3Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic FeverNot yet recruitingNCT02483260

Search NIH Clinical Center for Lassa Fever


Cochrane evidence based reviews: Lassa Fever

Genetic Tests for Lassa Fever

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Anatomical Context for Lassa Fever

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MalaCards organs/tissues related to Lassa Fever:

33
Eye, Skin, Testes, T cells, Neutrophil, Lung

Animal Models for Lassa Fever or affiliated genes

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Publications for Lassa Fever

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Articles related to Lassa Fever:

(show top 50)    (show all 246)
idTitleAuthorsYear
1
Imported Lassa fever: a report of 2 cases in Ghana. (26022703)
2015
2
After the a89blood diamonda89 conflict: lassa fever in Sierra Leone. (25574547)
2014
3
Lassa fever in post-conflict sierra leone. (24651047)
2014
4
Hyperglycemic crisis precipitated by Lassa fever in a patient with previously undiagnosed type 2 diabetes mellitus. (25244282)
2014
5
Advanced vaccine candidates for Lassa fever. (23202493)
2012
6
Guidance for contact tracing of cases of Lassa fever, Ebola or Marburg haemorrhagic fever on an airplane: results of a European expert consultation. (23170851)
2012
7
Hospital-based surveillance for Lassa fever in Edo State, Nigeria, 2005-2008. (22594713)
2012
8
Pathogenesis of Lassa fever. (23202452)
2012
9
Aeromedical evacuation using an aircraft transit isolator of a patient with Lassa fever. (22606871)
2012
10
Pathogenesis of Lassa fever in cynomolgus macaques. (21548931)
2011
11
Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever. (21820469)
2011
12
Hydrogen peroxide vapour decontamination of a critical care unit room used to treat a patient with Lassa fever. (20451295)
2010
13
Imported Lassa fever, Pennsylvania, USA, 2010. (20875288)
2010
14
Safety, immunogenicity, and efficacy of the ML29 reassortant vaccine for Lassa fever in small non-human primates. (18692539)
2008
15
Mastomys natalensis and Lassa fever, West Africa. (17326956)
2006
16
Lassa fever, Nigeria, 2003 and 2004. (16355508)
2005
17
The public health response to a case of Lassa fever in London in 2000. (15001300)
2004
18
Imported Lassa fever in Germany: surveillance and management of contact persons. (12746770)
2003
19
Lassa fever. (11987809)
2002
20
Lassa fever. (12138522)
2002
21
Short communication: Lassa fever in Sierra Leone: UN peacekeepers are at risk. (11251899)
2001
22
Murine immune responses to mucosally delivered Salmonella expressing Lassa fever virus nucleoprotein. (10618553)
2000
23
Effective vaccine for lassa fever. (10888616)
2000
24
Lassa fever imported to England. (10769487)
2000
25
The story of Lassa fever. Part I: Discovering the disease. (1614671)
1992
26
Lassa fever. (1995110)
1991
27
Acute sensorineural deafness in Lassa fever. (2214077)
1990
28
Deafness associated with Lassa fever. (2214082)
1990
29
Detection of Lassa virus RNA in specimens from patients with Lassa fever by using the polymerase chain reaction. (2279999)
1990
30
Plasma from patients with severe Lassa fever profoundly modulates f-met-leu-phe induced superoxide generation in neutrophils. (2554951)
1989
31
An imported case of Lassa fever with late appearance of polyserositis. (3171229)
1988
32
Pediatric Lassa fever: a review of 33 Liberian cases. (3826501)
1987
33
A prospective study of the epidemiology and ecology of Lassa fever. (3805771)
1987
34
Clinical virology of Lassa fever in hospitalized patients. (3805773)
1987
35
Lassa virus hepatitis: a study of fatal Lassa fever in humans. (3953952)
1986
36
Use of monoclonal antibody for the detection of Lassa virus antibody and antigen in patients with Lassa fever. (3523183)
1986
37
Journal of Infection Control Nursing. Nursing the isolated patient: Lassa fever. (3640375)
1986
38
Management of Lassa fever. (2867274)
1986
39
Patients with suspected Lassa fever in London during 1984. (3080068)
1986
40
Endemic Lassa fever in Liberia. IV. Selection of optimally effective plasma for treatment by passive immunization. (3898484)
1985
41
The use of Lassa fever convalescent plasma in Nigeria. (6464130)
1984
42
Endemic Lassa fever in Liberia. II. Serological and virological findings in hospital patients. (6390808)
1984
43
Lassa fever antibodies in hospital personnel in the Plateau State of Nigeria. (463337)
1979
44
Epidemiological aspect of the 1976 Pankshin Lassa fever outbreak. (463336)
1979
45
Lassa fever (LF) and Marburg disease (MVD): occurrences, origins and diagnoses. (567823)
1978
46
The Lassa fever crisis. (832782)
1977
47
Lassa fever. (1264786)
1976
48
Unrecognized diseases in Africa. II. Lassa fever. (1165154)
1975
49
Hoosiers abroad--report of a case of Lassa fever. (4604539)
1974
50
Lassa fever. A study of 23 hospital cases. (5046379)
1972

Variations for Lassa Fever

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Expression for genes affiliated with Lassa Fever

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Search GEO for disease gene expression data for Lassa Fever.

Pathways for genes affiliated with Lassa Fever

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GO Terms for genes affiliated with Lassa Fever

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Biological processes related to Lassa Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1viral entry into host cellGO:00467189.7AXL, DAG1
2negative regulation of apoptotic processGO:00430668.9AXL, CD40LG, TMBIM4

Molecular functions related to Lassa Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1virus receptor activityGO:00016189.5AXL, DAG1

Sources for Lassa Fever

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet