LF
MCID: LSS003
MIFTS: 45

Lassa Fever (LF) malady

Infectious diseases category

Summaries for Lassa Fever

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection, has material basis in lassa virus, which is transmitted by multimammate rat of the genus mastomys. the infection has symptom fever, has symptom retrosternal pain, has symptom sore throat, has symptom back pain, has symptom cough, has symptom abdominal pain, has symptom vomiting, has symptom diarrhea, has symptom conjunctivitis, has symptom facial swelling, has symptom proteinuria (protein in the urine), and has symptom mucosal bleeding.

MalaCards: Lassa Fever, also known as hemorrhagic fevers, viral, is related to lymphocytic choriomeningitis and argentine hemorrhagic fever, and has symptoms including abdominal pain, fever and early death/lethality. An important gene associated with Lassa Fever is DAG1 (dystroglycan 1 (dystrophin-associated glycoprotein 1)). Affiliated tissues include eye, testes and t cells.

CDC:3 Lassa fever is an acute viral illness that occurs in west Africa. The illness was discovered in 1969 when two missionary nurses died in Nigeria. The virus is named after the town in Nigeria where the first cases occurred. The virus, a member of the virus family Arenaviridae, is a single-stranded RNA virus and is zoonotic, or animal-borne.

Wikipedia:63 Lassa fever or Lassa hemorrhagic fever (LHF) is an acute viral hemorrhagic fever caused by the Lassa... more...

Aliases & Classifications for Lassa Fever

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
lassa fever:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

lassa fever 8 10 44 48 60
hemorrhagic fevers, viral 60
lassa hemorrhagic fever 48
lf 48


External Ids:

Disease Ontology8 DOID:9537
MeSH34 D007835
MESH via Orphanet35 D007835
ICD10 via Orphanet26 A96.2
SNOMED-CT56 19065005
SNOMED-CT via Orphanet57 19065005
UMLS via Orphanet61 C0023092
ICD1025 A96.2

Related Diseases for Lassa Fever

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Lassa Fever:



Diseases related to lassa fever

Clinical Features for Lassa Fever

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 41)
  • abdominal pain
  • fever
  • early death/lethality
  • obnubilation/coma/lethargia/desorientation
  • seizures/epilepsy/absences/spasms/status epilepticus
  • cranial hypertension
  • lymphadenopathy/polyadenopathies
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • retrosternal pain
  • sore throat
  • back pain
  • cough
  • vomiting
  • diarrhea
  • conjunctivitis
  • facial swelling
  • proteinuria (protein in the urine)
  • mucosal bleeding
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • pharyngitis
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • dizziness
  • palpebral edema/periorbital edema
  • conjunctival injection/chemosis/red eye
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • spontaneous abortions
  • asthenia/fatigue/weakness
  • fever/chilling
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • acute diarrhea
  • cutaneous rash
  • hearing loss/hypoacusia/deafness
  • thrombocytopenia/thrombopenia
  • leukopenia/hypoleukocytosis
  • articular/joint pain/arthralgia
  • myalgia/muscular pain
  • facial pain/cephalalgia/migraine
  • thoracic/chest pain
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea

Drugs & Therapeutics for Lassa Fever

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lassa Fever

Drug clinical trials:

Search ClinicalTrials for Lassa Fever

Search NIH Clinical Center for Lassa Fever

Search CenterWatch for Lassa Fever

Genetic Tests for Lassa Fever

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Anatomical Context for Lassa Fever

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Sources:
32MalaCards
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MalaCards organs/tissues related to Lassa Fever:

32
Eye, Testes, T cells, Lung

Animal Models for Lassa Fever or affiliated genes

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Publications for Lassa Fever

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Sources:
50PubMed
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Articles related to Lassa Fever:

(show top 50)    (show all 237)
idTitleAuthorsYear
1
Containing a Lassa fever epidemic in a resource-limited setting: outbreak description and lessons learned from Abakaliki, Nigeria (January-March 2012). (23871405)
2013
2
Housing equity for health equity: a rights-based approach to the control of Lassa fever in post-war Sierra Leone. (23282054)
2013
3
The search for animal models for Lassa fever vaccine development. (23256740)
2013
4
Hospital-based surveillance for Lassa fever in Edo State, Nigeria, 2005-2008. (22594713)
2012
5
Aeromedical evacuation using an aircraft transit isolator of a patient with Lassa fever. (22606871)
2012
6
Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever. (22312054)
2012
7
Lassa fever in West Africa: evidence for an expanded region of endemicity. (22958249)
2012
8
Capacity building permitting comprehensive monitoring of a severe case of Lassa hemorrhagic fever in Sierra Leone with a positive outcome: case report. (21689444)
2011
9
T cell-dependence of Lassa fever pathogenesis. (20360949)
2010
10
Laboratory diagnosis of Lassa fever, liberia. (20507774)
2010
11
Review of the literature and proposed guidelines for the use of oral ribavirin as postexposure prophylaxis for Lassa fever. (21058912)
2010
12
Risk maps of Lassa fever in West Africa. (19255625)
2009
13
NMR assignment of the arenaviral protein Z from Lassa fever virus. (18958179)
2008
14
Mastomys natalensis and Lassa fever, West Africa. (17326956)
2006
15
Characterization of the interaction of lassa fever virus with its cellular receptor alpha-dystroglycan. (15857984)
2005
16
Management of a patient with Lassa fever to prevent transmission. (14572492)
2003
17
Monitoring of clinical and laboratory data in two cases of imported Lassa fever. (11825774)
2002
18
Murine immune responses to mucosally delivered Salmonella expressing Lassa fever virus nucleoprotein. (10618553)
2000
19
Lassa fever, case imported to Germany. (10686828)
2000
20
Completion of the Lassa fever virus sequence and identification of a RING finger open reading frame at the L RNA 5' End. (9281522)
1997
21
The Lassa fever virus L gene: nucleotide sequence, comparison, and precipitation of a predicted 250 kDa protein with monospecific antiserum. (9049403)
1997
22
The story of Lassa fever. Part I: Discovering the disease. (1614671)
1992
23
Exchange transfusion of a patient with fulminant Lassa fever. (2041853)
1991
24
Detection of Lassa virus RNA in specimens from patients with Lassa fever by using the polymerase chain reaction. (2279999)
1990
25
Lassa fever: the first confirmed case imported into Canada. (2590947)
1989
26
A case-control study of the clinical diagnosis and course of Lassa fever. (3805772)
1987
27
Vaccinia recombinant expressing Lassa-virus internal nucleocapsid protein protects guineapigs against Lassa fever. (2885642)
1987
28
Management of Lassa fever. (2867274)
1986
29
Lassa fever. (3096456)
1986
30
Management of Lassa fever. (2866407)
1985
31
Lassa fever and pregnancy. (3846752)
1985
32
Early diagnosis of human Lassa fever by ELISA detection of antigen and antibody. (2857321)
1985
33
The use of Lassa fever convalescent plasma in Nigeria. (6464130)
1984
34
Endemic Lassa fever in Liberia. II. Serological and virological findings in hospital patients. (6390808)
1984
35
Lassa fever in London: environmental health aspects. (6734142)
1984
36
Possible approaches to a vaccine against Lassa fever. (6464128)
1984
37
Passive antibody therapy of Lassa fever in cynomolgus monkeys: importance of neutralizing antibody and Lassa virus strain. (6715049)
1984
38
Lassa fever in children. (7185979)
1982
39
Clinical observations in 42 patients with Lassa fever. (7233535)
1980
40
Lassa fever virus: properties and characteristics. (111436)
1979
41
Lassa fever: clinical symptoms and laboratory diagnosis. (463322)
1979
42
A serological survey of Lassa fever in Liberia. (310723)
1978
43
The Lassa fever crisis. (832782)
1977
44
Lassa fever: response to an imported case. (895819)
1977
45
Lassa fever surveillance: the need for better communication]. (872014)
1977
46
Unrecognized diseases in Africa. II. Lassa fever. (1165154)
1975
47
Lassa fever in Onitsha, East Central State, Nigeria in 1974. (1085214)
1975
48
Lassa fever and Marburg virus disease. (4208764)
1974
49
Lassa fever. (4213599)
1974
50
Lassa fever. (4110056)
1972

Genetic Variations for Lassa Fever

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Expression for genes affiliated with Lassa Fever

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lassa Fever

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Pathways for genes affiliated with Lassa Fever

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Compounds for genes affiliated with Lassa Fever

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GO Terms for genes affiliated with Lassa Fever

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16Gene Ontology
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Cellular components related to Lassa Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi stackGO:0057959.2TMBIM4, MBTPS1
2Golgi membraneGO:0001399.2TMBIM4, GYLTL1B, MBTPS1

Biological processes related to Lassa Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum unfolded protein responseGO:0309689.6MBTPS1, IFNG

Products for genes affiliated with Lassa Fever

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lassa Fever

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet