LF
MCID: LSS003
MIFTS: 41

Lassa Fever (LF) malady

Infectious diseases, Rare diseases categories
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Summaries for Lassa Fever

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Disease Ontology:8 A viral infectious disease that results in infection, has material basis in lassa virus, which is transmitted by multimammate rat of the genus mastomys. the infection has symptom fever, has symptom retrosternal pain, has symptom sore throat, has symptom back pain, has symptom cough, has symptom abdominal pain, has symptom vomiting, has symptom diarrhea, has symptom conjunctivitis, has symptom facial swelling, has symptom proteinuria (protein in the urine), and has symptom mucosal bleeding.

MalaCards based summary: Lassa Fever, also known as hemorrhagic fevers, viral, is related to lymphocytic choriomeningitis and vaccinia, and has symptoms including metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea, fever/chilling and asthenia/fatigue/weakness. An important gene associated with Lassa Fever is DAG1 (dystroglycan 1 (dystrophin-associated glycoprotein 1)), and among its related pathways is Allograft rejection. Affiliated tissues include eye, testes and t cells.

CDC:3 Lassa fever is an acute viral illness that occurs in west Africa. The illness was discovered in 1969 when two missionary nurses died in Nigeria. The virus is named after the town in Nigeria where the first cases occurred. The virus, a member of the virus family Arenaviridae, is a single-stranded RNA virus and is zoonotic, or animal-borne.

Aliases & Classifications for Lassa Fever

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 34MeSH, 57SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Lassa Fever, Aliases & Descriptions:

Name: Lassa Fever 8 10 44 48 62
Hemorrhagic Fevers, Viral 62
 
Lassa Hemorrhagic Fever 48
Lf 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases


Characteristics (Orphanet epidemiological data):

48
lassa fever:
Age of onset: Variable; Age of death: Any age


External Ids:

Disease Ontology8 DOID:9537
MeSH34 D007835
MESH via Orphanet35 D007835
SNOMED-CT57 19065005
ICD10 via Orphanet26 A96.2
UMLS via Orphanet63 C0023092
ICD1025 A99, A96.2, A98.8

Related Diseases for Lassa Fever

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Diseases related to Lassa Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 13)
idRelated DiseaseScoreTop Affiliating Genes
1lymphocytic choriomeningitis30.5GP2, DAG1
2vaccinia10.4
3hemorrhagic fever10.4
4sensorineural hearing loss10.3
5diabetes mellitus10.2
6hepatitis10.2
7type 2 diabetes mellitus10.2
8rift valley fever10.2
9yellow fever10.2
10hepatitis a10.2
11leprosy10.2
12smallpox10.2
13viral hemorrhagic fever10.2

Graphical network of diseases related to Lassa Fever:



Diseases related to lassa fever

Symptoms for Lassa Fever

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Symptoms:

48 (show all 30)
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • fever/chilling
  • asthenia/fatigue/weakness
  • spontaneous abortions
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • conjunctival injection/chemosis/red eye
  • palpebral edema/periorbital edema
  • dizziness
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • pharyngitis
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • acute diarrhea
  • thoracic/chest pain
  • cough
  • facial pain/cephalalgia/migraine
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • leukopenia/hypoleukocytosis
  • thrombocytopenia/thrombopenia
  • hearing loss/hypoacusia/deafness
  • cutaneous rash
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • lymphadenopathy/polyadenopathies
  • cranial hypertension
  • seizures/epilepsy/absences/spasms/status epilepticus
  • obnubilation/coma/lethargia/desorientation
  • early death/lethality

HPO human phenotypes related to Lassa Fever:

(show all 48)
id Description Frequency HPO Source Accession
1 abnormality of temperature regulation hallmark (90%) HP:0004370
2 abnormality of the menstrual cycle hallmark (90%) HP:0000140
3 abnormality of temperature regulation hallmark (90%) HP:0004370
4 spontaneous abortion hallmark (90%) HP:0005268
5 abnormality of the menstrual cycle typical (50%) HP:0000140
6 gingival bleeding typical (50%) HP:0000225
7 epistaxis typical (50%) HP:0000421
8 conjunctivitis typical (50%) HP:0000509
9 thrombocytopenia typical (50%) HP:0001873
10 leukopenia typical (50%) HP:0001882
11 subcutaneous hemorrhage typical (50%) HP:0001933
12 diarrhea typical (50%) HP:0002014
13 nausea and vomiting typical (50%) HP:0002017
14 abdominal pain typical (50%) HP:0002027
15 migraine typical (50%) HP:0002076
16 gastrointestinal hemorrhage typical (50%) HP:0002239
17 arthralgia typical (50%) HP:0002829
18 myalgia typical (50%) HP:0003326
19 spontaneous abortion typical (50%) HP:0005268
20 chest pain typical (50%) HP:0100749
21 conjunctivitis typical (50%) HP:0000509
22 thrombocytopenia typical (50%) HP:0001873
23 leukopenia typical (50%) HP:0001882
24 diarrhea typical (50%) HP:0002014
25 nausea and vomiting typical (50%) HP:0002017
26 abdominal pain typical (50%) HP:0002027
27 migraine typical (50%) HP:0002076
28 vertigo typical (50%) HP:0002321
29 arthralgia typical (50%) HP:0002829
30 myalgia typical (50%) HP:0003326
31 periorbital edema typical (50%) HP:0100539
32 chest pain typical (50%) HP:0100749
33 recurrent pharyngitis typical (50%) HP:0100776
34 hearing impairment occasional (7.5%) HP:0000365
35 seizures occasional (7.5%) HP:0001250
36 encephalitis occasional (7.5%) HP:0002383
37 reduced consciousness/confusion occasional (7.5%) HP:0004372
38 recurrent bronchiolitis occasional (7.5%) HP:0100501
39 retrobulbar optic neuritis occasional (7.5%) HP:0100654
40 hearing impairment occasional (7.5%) HP:0000365
41 skin rash occasional (7.5%) HP:0000988
42 seizures occasional (7.5%) HP:0001250
43 sudden cardiac death occasional (7.5%) HP:0001645
44 abnormality of the pleura occasional (7.5%) HP:0002103
45 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
46 increased intracranial pressure occasional (7.5%) HP:0002516
47 lymphadenopathy occasional (7.5%) HP:0002716
48 reduced consciousness/confusion occasional (7.5%) HP:0004372

Drugs & Therapeutics for Lassa Fever

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Drug clinical trials:

Search ClinicalTrials for Lassa Fever

Search NIH Clinical Center for Lassa Fever

Genetic Tests for Lassa Fever

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Anatomical Context for Lassa Fever

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MalaCards organs/tissues related to Lassa Fever:

32
Eye, Testes, T cells, Lung, Neutrophil

Animal Models for Lassa Fever or affiliated genes

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Publications for Lassa Fever

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Articles related to Lassa Fever:

(show top 50)    (show all 236)
idTitleAuthorsYear
1
Lassa fever in post-conflict sierra leone. (24651047)
2014
2
Hyperglycemic crisis precipitated by Lassa fever in a patient with previously undiagnosed type 2 diabetes mellitus. (25244282)
2014
3
Production of CXC and CC Chemokines by Human Antigen-Presenting Cells in Response to Lassa Virus or Closely Related Immunogenic Viruses, and in Cynomolgus Monkeys with Lassa Fever. (24421914)
2014
4
Advanced vaccine candidates for Lassa fever. (23202493)
2012
5
Guidance for contact tracing of cases of Lassa fever, Ebola or Marburg haemorrhagic fever on an airplane: results of a European expert consultation. (23170851)
2012
6
Hospital-based surveillance for Lassa fever in Edo State, Nigeria, 2005-2008. (22594713)
2012
7
Pathogenesis of Lassa fever. (23202452)
2012
8
Aeromedical evacuation using an aircraft transit isolator of a patient with Lassa fever. (22606871)
2012
9
Pathogenesis of Lassa fever in cynomolgus macaques. (21548931)
2011
10
Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever. (21820469)
2011
11
Hydrogen peroxide vapour decontamination of a critical care unit room used to treat a patient with Lassa fever. (20451295)
2010
12
Imported Lassa fever, Pennsylvania, USA, 2010. (20875288)
2010
13
T cell-dependence of Lassa fever pathogenesis. (20360949)
2010
14
Safety, immunogenicity, and efficacy of the ML29 reassortant vaccine for Lassa fever in small non-human primates. (18692539)
2008
15
Mastomys natalensis and Lassa fever, West Africa. (17326956)
2006
16
Lassa fever, Nigeria, 2003 and 2004. (16355508)
2005
17
The public health response to a case of Lassa fever in London in 2000. (15001300)
2004
18
Imported Lassa fever in Germany: surveillance and management of contact persons. (12746770)
2003
19
Lassa fever. (11987809)
2002
20
Lassa fever. (12138522)
2002
21
Short communication: Lassa fever in Sierra Leone: UN peacekeepers are at risk. (11251899)
2001
22
Murine immune responses to mucosally delivered Salmonella expressing Lassa fever virus nucleoprotein. (10618553)
2000
23
Effective vaccine for lassa fever. (10888616)
2000
24
Lassa fever imported to England. (10769487)
2000
25
The story of Lassa fever. Part I: Discovering the disease. (1614671)
1992
26
Lassa fever. (1995110)
1991
27
Acute sensorineural deafness in Lassa fever. (2214077)
1990
28
Deafness associated with Lassa fever. (2214082)
1990
29
Detection of Lassa virus RNA in specimens from patients with Lassa fever by using the polymerase chain reaction. (2279999)
1990
30
Plasma from patients with severe Lassa fever profoundly modulates f-met-leu-phe induced superoxide generation in neutrophils. (2554951)
1989
31
An imported case of Lassa fever with late appearance of polyserositis. (3171229)
1988
32
Pediatric Lassa fever: a review of 33 Liberian cases. (3826501)
1987
33
A prospective study of the epidemiology and ecology of Lassa fever. (3805771)
1987
34
Clinical virology of Lassa fever in hospitalized patients. (3805773)
1987
35
Lassa virus hepatitis: a study of fatal Lassa fever in humans. (3953952)
1986
36
Journal of Infection Control Nursing. Nursing the isolated patient: Lassa fever. (3640375)
1986
37
Management of Lassa fever. (2867274)
1986
38
Patients with suspected Lassa fever in London during 1984. (3080068)
1986
39
Endemic Lassa fever in Liberia. IV. Selection of optimally effective plasma for treatment by passive immunization. (3898484)
1985
40
The use of Lassa fever convalescent plasma in Nigeria. (6464130)
1984
41
Endemic Lassa fever in Liberia. II. Serological and virological findings in hospital patients. (6390808)
1984
42
Lassa fever antibodies in hospital personnel in the Plateau State of Nigeria. (463337)
1979
43
Epidemiological aspect of the 1976 Pankshin Lassa fever outbreak. (463336)
1979
44
Lassa fever (LF) and Marburg disease (MVD): occurrences, origins and diagnoses. (567823)
1978
45
The Lassa fever crisis. (832782)
1977
46
Lassa fever. (1264786)
1976
47
Lassa fever (arenaviruses) as a public health problem. (1026322)
1976
48
Unrecognized diseases in Africa. II. Lassa fever. (1165154)
1975
49
Hoosiers abroad--report of a case of Lassa fever. (4604539)
1974
50
Lassa fever. A study of 23 hospital cases. (5046379)
1972

Variations for Lassa Fever

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Expression for genes affiliated with Lassa Fever

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Expression patterns in normal tissues for genes affiliated with Lassa Fever

Search GEO for disease gene expression data for Lassa Fever.

Pathways for genes affiliated with Lassa Fever

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Pathways related to Lassa Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5IFNG, DAG1

Compounds for genes affiliated with Lassa Fever

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GO Terms for genes affiliated with Lassa Fever

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Products for genes affiliated with Lassa Fever

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  • Antibodies
  • Proteins
  • Lysates

Sources for Lassa Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet