MCID: LSS003
MIFTS: 45

Lassa Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Lassa Fever

MalaCards integrated aliases for Lassa Fever:

Name: Lassa Fever 12 72 55 51 3 41 14 69
Lassa Hemorrhagic Fever 55
Lf 55

Characteristics:

Orphanet epidemiological data:

55
lassa fever
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 55  
Rare infectious diseases


Summaries for Lassa Fever

CDC : 3 Lassa fever is endemic in parts of west Africa including Sierra Leone, Liberia, Guinea and Nigeria; however, other neighboring countries are also at risk, as the animal vector for Lassa virus, the "multimammate rat" (Mastomys natalensis) is distributed throughout the region. In 2009, the first case from Mali was reported in a traveler living in southern Mali; Ghana reported its first cases in late 2011. Isolated cases have also been reported in Côte d’Ivoire and Burkina Faso and there is serologic evidence of Lassa virus infection in Togo and Benin.

MalaCards based summary : Lassa Fever, also known as lassa hemorrhagic fever, is related to lymphocytic choriomeningitis and hemorrhagic fever, and has symptoms including fever, retrosternal pain and sore throat. An important gene associated with Lassa Fever is DAG1 (Dystroglycan 1), and among its related pathways/superpathways is Post-translational modification- synthesis of GPI-anchored proteins. The drugs Ribavirin and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A viral infectious disease that results_in infection, has material basis in Lassa virus, which is transmitted_by multimammate rat of the genus Mastomys. The infection has symptom fever, has symptom retrosternal pain, has symptom sore throat, has symptom back pain, has symptom cough, has symptom abdominal pain, has symptom vomiting, has symptom diarrhea, has symptom conjunctivitis, has symptom facial swelling, has symptom proteinuria (protein in the urine), and has symptom mucosal bleeding.

Wikipedia : 72 Lassa fever, also known as Lassa hemorrhagic fever (LHF), is a type of viral hemorrhagic fever caused by... more...

Related Diseases for Lassa Fever

Graphical network of the top 20 diseases related to Lassa Fever:



Diseases related to Lassa Fever

Symptoms & Phenotypes for Lassa Fever

Symptoms:

12 (show all 12)
  • fever
  • retrosternal pain
  • sore throat
  • back pain
  • cough
  • abdominal pain
  • vomiting
  • diarrhea
  • conjunctivitis
  • facial swelling
  • proteinuria (protein in the urine)
  • mucosal bleeding

Human phenotypes related to Lassa Fever:

55 31 (show all 29)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hearing impairment 55 31 occasional (7.5%) Occasional (29-5%) HP:0000365
2 conjunctivitis 55 31 frequent (33%) Frequent (79-30%) HP:0000509
3 skin rash 55 31 occasional (7.5%) Occasional (29-5%) HP:0000988
4 seizures 55 31 occasional (7.5%) Occasional (29-5%) HP:0001250
5 lethargy 55 31 occasional (7.5%) Occasional (29-5%) HP:0001254
6 subcutaneous nodule 55 31 frequent (33%) Frequent (79-30%) HP:0001482
7 thrombocytopenia 55 31 frequent (33%) Frequent (79-30%) HP:0001873
8 leukopenia 55 31 frequent (33%) Frequent (79-30%) HP:0001882
9 fever 55 31 hallmark (90%) Very frequent (99-80%) HP:0001945
10 diarrhea 55 31 frequent (33%) Frequent (79-30%) HP:0002014
11 nausea and vomiting 55 31 frequent (33%) Frequent (79-30%) HP:0002017
12 abdominal pain 55 31 frequent (33%) Frequent (79-30%) HP:0002027
13 pleural effusion 55 31 occasional (7.5%) Occasional (29-5%) HP:0002202
14 gastrointestinal hemorrhage 55 31 occasional (7.5%) Occasional (29-5%) HP:0002239
15 headache 55 31 frequent (33%) Frequent (79-30%) HP:0002315
16 vertigo 55 31 frequent (33%) Frequent (79-30%) HP:0002321
17 increased intracranial pressure 55 31 occasional (7.5%) Occasional (29-5%) HP:0002516
18 lymphadenopathy 55 31 occasional (7.5%) Occasional (29-5%) HP:0002716
19 arthralgia 55 31 frequent (33%) Frequent (79-30%) HP:0002829
20 myalgia 55 31 frequent (33%) Frequent (79-30%) HP:0003326
21 spontaneous abortion 55 31 hallmark (90%) Very frequent (99-80%) HP:0005268
22 cardiorespiratory arrest 55 31 occasional (7.5%) Occasional (29-5%) HP:0006543
23 chemosis 55 31 frequent (33%) Frequent (79-30%) HP:0012375
24 fatigue 55 31 hallmark (90%) Very frequent (99-80%) HP:0012378
25 cough 55 31 frequent (33%) Frequent (79-30%) HP:0012735
26 palpebral edema 55 31 frequent (33%) Frequent (79-30%) HP:0100540
27 chest pain 55 31 frequent (33%) Frequent (79-30%) HP:0100749
28 recurrent pharyngitis 55 31 frequent (33%) Frequent (79-30%) HP:0100776
29 menometrorrhagia 55 31 hallmark (90%) Very frequent (99-80%) HP:0400008

GenomeRNAi Phenotypes related to Lassa Fever according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 CD40LG CH25H DAG1 GPR132
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 CD40LG CH25H DAG1 GPR132

Drugs & Therapeutics for Lassa Fever

Drugs for Lassa Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 2 36791-04-5 37542
2 Anti-Infective Agents Phase 2
3 Antimetabolites Phase 2
4 Antiviral Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment Facilities Enrolling by invitation NCT00992693 Phase 2 Ribavirin (Virazole) Injection
2 Seroprevalence and Incidence of Lassa Fever in the Rural Commune of Sibirila, District of Bougouni, Mali Completed NCT02311387
3 Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic Fever Enrolling by invitation NCT02483260 Ribavirin

Search NIH Clinical Center for Lassa Fever

Cochrane evidence based reviews: lassa fever

Genetic Tests for Lassa Fever

Anatomical Context for Lassa Fever

MalaCards organs/tissues related to Lassa Fever:

38
Skin, Testes, T Cells, Neutrophil, Lung

Publications for Lassa Fever

Articles related to Lassa Fever:

(show top 50) (show all 284)
# Title Authors Year
1
Mortality Among Confirmed Lassa Fever Cases During the 2015-2016 Outbreak in Nigeria. ( 29267063 )
2018
2
The challenges of detecting and responding to a Lassa fever outbreak in an Ebola-affected setting. ( 29138016 )
2018
3
Discharge Criteria for Patient With Lassa Fever Infection. ( 29186289 )
2018
4
Expression and X-Ray Structural Determination of the Nucleoprotein of Lassa Fever Virus. ( 28986833 )
2018
5
Diagnostics for Lassa Fever: Detecting Host Antibody Responses. ( 28986826 )
2018
6
Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever. ( 28869611 )
2017
7
Moving Lassa Fever Research and Care Into the 21st Century. ( 28863471 )
2017
8
Understanding the cryptic nature of Lassa fever in West Africa. ( 28875769 )
2017
9
Laboratory Diagnosis of Lassa Fever. ( 28404674 )
2017
10
Epidemic preparedness and management: A guide on Lassa fever outbreak preparedness plan. ( 29238121 )
2017
11
Knowledge Attitude and Practices Toward Lassa Fever Control and Prevention Among Residents of Ile-Ife, Southwest Nigeria. ( 28511600 )
2017
12
Lassa fever. ( 28701331 )
2017
13
Lessons learnt from imported cases and onward transmission of Lassa fever in Europe support broader management of viral haemorrhagic fevers. ( 29019310 )
2017
14
Metabolomics analyses identify platelet activating factors and heme breakdown products as Lassa fever biomarkers. ( 28922385 )
2017
15
A DNA vaccine delivered by dermal electroporation fully protects cynomolgus macaques against Lassa fever. ( 29045192 )
2017
16
Control measures following a case of imported Lassa fever from Togo, North Rhine Westphalia, Germany, 2016. ( 29019307 )
2017
17
Favipiravir and Ribavirin Treatment of Epidemiologically Linked Cases of Lassa Fever. ( 29017278 )
2017
18
Emergence of Lassa Fever Disease in Northern Togo: Report of Two Cases in Oti District in 2016. ( 29391958 )
2017
19
Management of a Lassa fever outbreak, Rhineland-Palatinate, Germany, 2016. ( 29019309 )
2017
20
Outbreak of lassa fever in Nigeria: measures for prevention and control. ( 27347299 )
2016
21
Lassa Fever in Pregnancy: Report of 2 Cases Seen at the University College Hospital, Ibadan. ( 27051545 )
2016
22
As Ebola winds down, Lassa Fever reemerges yet again in West Africa. ( 26927465 )
2016
23
Vaccine platforms to control Lassa fever. ( 27136941 )
2016
24
Lassa fever. ( 27333233 )
2016
25
Lassa fever: another threat from West Africa. ( 28265442 )
2016
26
Chimeric Mice with Competent Hematopoietic Immunity Reproduce Key Features of Severe Lassa Fever. ( 27191716 )
2016
27
Imported Case of Lassa Fever in Sweden With Encephalopathy and Sensorineural Hearing Deficit. ( 27975074 )
2016
28
Rat-atouille: A Mixed Method Study to Characterize Rodent Hunting and Consumption in the Context of Lassa Fever. ( 26895631 )
2016
29
Epidemic focus: Lassa Fever. ( 27236868 )
2016
30
An Outbreak of Ebola Virus Disease in the Lassa Fever Zone. ( 27402779 )
2016
31
Postexposure prophylaxis for Lassa fever: Experience from a recent outbreak in Nigeria. ( 27630390 )
2016
32
Molecular confirmation of Lassa fever imported into Ghana. ( 28879105 )
2016
33
Imported Lassa fever: a report of 2 cases in Ghana. ( 26022703 )
2015
34
A Recombinant Vesicular Stomatitis Virus-Based Lassa Fever Vaccine Protects Guinea Pigs and Macaques against Challenge with Geographically and Genetically Distinct Lassa Viruses. ( 25884628 )
2015
35
Development of a time-trend model for analyzing and predicting case-pattern of Lassa fever epidemics in Liberia, 2013-2017. ( 25693816 )
2015
36
Mapping of Lassa fever cases in post-conflict Liberia, 2008-2012: a descriptive and categorical analysis of age, gender and seasonal pattern. ( 25693822 )
2015
37
Using modelling to disentangle the relative contributions of zoonotic and anthroponotic transmission: the case of lassa fever. ( 25569707 )
2015
38
Lassa fever or lassa hemorrhagic fever risk to humans from rodent-borne zoonoses. ( 26012219 )
2015
39
Lessons learnt from the management of a case of Lassa fever and follow-up of nosocomial primary contacts in Nigeria during Ebola virus disease outbreak in West Africa. ( 26171669 )
2015
40
Efficacy of favipiravir alone and in combination with ribavirin in a lethal, immunocompetent mouse model for Lassa fever. ( 26531247 )
2015
41
Engaging Market Traders in Lassa Fever Campaign: Assessment of Knowledge and Risk Behaviour. ( 27492545 )
2015
42
Knowledge of Secondary School Children in Edo State on Lassa Fever and its Implications for Prevention and Control. ( 27492547 )
2015
43
Mapping the zoonotic niche of Lassa fever in Africa. ( 26085474 )
2015
44
Constraints in the diagnosis and treatment of Lassa Fever and the effect on mortality in hospitalized children and women with obstetric conditions in a rural district hospital in Sierra Leone. ( 24535150 )
2014
45
Production of CXC and CC Chemokines by Human Antigen-Presenting Cells in Response to Lassa Virus or Closely Related Immunogenic Viruses, and in Cynomolgus Monkeys with Lassa Fever. ( 24421914 )
2014
46
VaxCelerate II: rapid development of a self-assembling vaccine for Lassa fever. ( 25483693 )
2014
47
Mapping transmission risk of Lassa fever in West Africa: the importance of quality control, sampling bias, and error weighting. ( 25105746 )
2014
48
Lassa fever - full recovery without ribavarin treatment: a case report. ( 25834520 )
2014
49
Lassa fever in post-conflict sierra leone. ( 24651047 )
2014
50
Diagnostic proficiency and reporting of Lassa fever by physicians in Osun State of Nigeria. ( 24950705 )
2014

Variations for Lassa Fever

Expression for Lassa Fever

Search GEO for disease gene expression data for Lassa Fever.

Pathways for Lassa Fever

Pathways related to Lassa Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.62 GP2 PIGC

GO Terms for Lassa Fever

Biological processes related to Lassa Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet activation GO:0030168 8.96 AXL CD40LG
2 viral entry into host cell GO:0046718 8.62 AXL DAG1

Molecular functions related to Lassa Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.62 AXL DAG1

Sources for Lassa Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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