LF
MCID: LSS003
MIFTS: 45

Lassa Fever (LF) malady

Infectious diseases category

Summaries for Lassa Fever

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection, has material basis in lassa virus, which is transmitted by multimammate rat of the genus mastomys. the infection has symptom fever, has symptom retrosternal pain, has symptom sore throat, has symptom back pain, has symptom cough, has symptom abdominal pain, has symptom vomiting, has symptom diarrhea, has symptom conjunctivitis, has symptom facial swelling, has symptom proteinuria (protein in the urine), and has symptom mucosal bleeding.

MalaCards: Lassa Fever, also known as hemorrhagic fevers, viral, is related to lymphocytic choriomeningitis and argentine hemorrhagic fever, and has symptoms including vomiting, conjunctival injection/chemosis/red eye and spontaneous abortions. An important gene associated with Lassa Fever is DAG1 (dystroglycan 1 (dystrophin-associated glycoprotein 1)). Affiliated tissues include eye, testes and t cells.

CDC:3 Lassa fever is an acute viral illness that occurs in west Africa. The illness was discovered in 1969 when two missionary nurses died in Nigeria. The virus is named after the town in Nigeria where the first cases occurred. The virus, a member of the virus family Arenaviridae, is a single-stranded RNA virus and is zoonotic, or animal-borne.

Wikipedia:63 Lassa fever or Lassa hemorrhagic fever (LHF) is an acute viral hemorrhagic fever caused by the Lassa... more...

Aliases & Classifications for Lassa Fever

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
lassa fever:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

lassa fever 8 10 44 48 60
hemorrhagic fevers, viral 60
lassa hemorrhagic fever 48
lf 48


External Ids:

Disease Ontology8 DOID:9537
MeSH34 D007835
MESH via Orphanet35 D007835
ICD10 via Orphanet26 A96.2
SNOMED-CT56 19065005
SNOMED-CT via Orphanet57 19065005
UMLS via Orphanet61 C0023092
ICD1025 A96.2

Related Diseases for Lassa Fever

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Lassa Fever:



Diseases related to lassa fever

Clinical Features for Lassa Fever

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 41)
  • vomiting
  • conjunctival injection/chemosis/red eye
  • spontaneous abortions
  • leukopenia/hypoleukocytosis
  • acute diarrhea
  • lymphadenopathy/polyadenopathies
  • palpebral edema/periorbital edema
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • fever
  • conjunctivitis
  • abdominal pain
  • diarrhea
  • sore throat
  • back pain
  • retrosternal pain
  • facial swelling
  • proteinuria (protein in the urine)
  • mucosal bleeding
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • pharyngitis
  • articular/joint pain/arthralgia
  • fever/chilling
  • asthenia/fatigue/weakness
  • obnubilation/coma/lethargia/desorientation
  • cranial hypertension
  • hearing loss/hypoacusia/deafness
  • early death/lethality
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • seizures/epilepsy/absences/spasms/status epilepticus
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • cutaneous rash
  • thoracic/chest pain
  • dizziness
  • facial pain/cephalalgia/migraine
  • thrombocytopenia/thrombopenia
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • acute abdominal pain/colic
  • myalgia/muscular pain
  • cough
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Lassa Fever

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lassa Fever

Drug clinical trials:

Search ClinicalTrials for Lassa Fever

Search NIH Clinical Center for Lassa Fever

Search CenterWatch for Lassa Fever

Genetic Tests for Lassa Fever

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Anatomical Context for Lassa Fever

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Sources:
32MalaCards
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MalaCards organs/tissues related to Lassa Fever:

32
Eye, Testes, T cells, Lung

Animal Models for Lassa Fever or affiliated genes

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Publications for Lassa Fever

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Sources:
50PubMed
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Articles related to Lassa Fever:

(show top 50)    (show all 237)
idTitleAuthorsYear
1
Pathogenesis of Lassa fever virus infection: I. Susceptibility of mice to recombinant Lassa Gp/LCMV chimeric virus. (23684417)
2013
2
Pathogenesis of Lassa fever. (23202452)
2012
3
The first cases of Lassa fever in Ghana. (23661832)
2012
4
Molecular diagnostics for lassa fever at Irrua specialist teaching hospital, Nigeria: lessons learnt from two years of laboratory operation. (23029594)
2012
5
Pathogenesis of Lassa fever in cynomolgus macaques. (21548931)
2011
6
Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever. (21820469)
2011
7
Lassa hemorrhagic fever in a late term pregnancy from northern Sierra Leone with a positive maternal outcome: case report. (21843352)
2011
8
Conserved residues in Lassa fever virus Z protein modulate viral infectivity at the level of the ribonucleoprotein. (21228230)
2011
9
Safety, immunogenicity, and efficacy of the ML29 reassortant vaccine for Lassa fever in small non-human primates. (18692539)
2008
10
Development of recombinant nucleoprotein-based diagnostic systems for Lassa fever. (17634509)
2007
11
Lassa fever in West African sub-region: an overview. (17378212)
2007
12
Historical Lassa fever reports and 30-year clinical update. (16704848)
2006
13
Update on Lassa fever in West Africa. (15831055)
2005
14
Lassa fever. (11987809)
2002
15
Lassa fever. (12138522)
2002
16
Low levels of interleukin-8 and interferon-inducible protein-10 in serum are associated with fatal infections in acute Lassa fever. (11372023)
2001
17
Lassa fever in Guinea: II. Distribution and prevalence of Lassa virus infection in small mammals. (12653128)
2001
18
Lassa fever imported to England. (10769487)
2000
19
Lassa fever, imported case, Netherlands. (10974948)
2000
20
People with Lassa fever. Interview by Anne Gulland. (9188427)
1997
21
Lassa fever. Update. (8695342)
1996
22
Audiometric comparison of Lassa fever hearing loss and idiopathic sudden hearing loss: evidence for viral cause. (1589210)
1992
23
The story of Lassa fever. Part III: The disease in the community. (1436814)
1992
24
Acute sensorineural deafness in Lassa fever. (2214077)
1990
25
Imported Lassa fever--reexamining the algorithms. (2215584)
1990
26
Clinical features of Lassa fever in Liberia. (2749109)
1989
27
Electrocardiographic abnormalities in patients with Lassa fever. (2810453)
1989
28
Protection of rhesus monkeys from fatal Lassa fever by vaccination with a recombinant vaccinia virus containing the Lassa virus glycoprotein gene. (2911575)
1989
29
Lassa fever: epidemiology, therapy and vaccine development. (3138361)
1988
30
Evidence against high contagiousness of Lassa fever. (3188161)
1988
31
Hematologic dysfunction in Lassa fever. (3183637)
1988
32
Lassa virus hepatitis: a study of fatal Lassa fever in humans. (3953952)
1986
33
Use of monoclonal antibody for the detection of Lassa virus antibody and antigen in patients with Lassa fever. (3523183)
1986
34
No evidence for increased risk of Lassa fever infection in hospital staff. (2877335)
1986
35
Endemic Lassa fever in Liberia. IV. Selection of optimally effective plasma for treatment by passive immunization. (3898484)
1985
36
Patients with suspected Lassa fever in London during 1984. (3935259)
1985
37
Enhanced treatment of Lassa fever by immune plasma combined with ribavirin in cynomolgus monkeys. (6715898)
1984
38
Lassa fever 1982. (6407689)
1983
39
A case of Lassa fever. (6814654)
1982
40
A case of Lassa fever: experience at St Thomas's Hospital. (6812717)
1982
41
A case of Lassa fever: clinical and virological findings. (6812716)
1982
42
A case of Lassa fever. (6812704)
1982
43
Preclinical evaluation of monkeys of a ribavirin regimen proposed for use in Lassa fever patients. (7112580)
1982
44
Exotic infectious diseases: Lassa fever. (7384424)
1980
45
Lassa fever (LF) and Marburg disease (MVD): occurrences, origins and diagnoses. (567823)
1978
46
Lassa Fever. (20312981)
1978
47
Lassa fever in Panguma Hospital, Sierra Leone, 1973-6. (861652)
1977
48
Lassa fever: review of epidemiology and epizootiology. (782738)
1975
49
Lassa fever. (1040192)
1975
50
Lassa fever. (4745120)
1973

Genetic Variations for Lassa Fever

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Expression for genes affiliated with Lassa Fever

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lassa Fever

Search GEO for disease gene expression data for Lassa Fever.

Pathways for genes affiliated with Lassa Fever

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Compounds for genes affiliated with Lassa Fever

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GO Terms for genes affiliated with Lassa Fever

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16Gene Ontology
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Cellular components related to Lassa Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi stackGO:0057959.2TMBIM4, MBTPS1
2Golgi membraneGO:0001399.2TMBIM4, GYLTL1B, MBTPS1

Biological processes related to Lassa Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum unfolded protein responseGO:0309689.6MBTPS1, IFNG

Products for genes affiliated with Lassa Fever

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Sources for Lassa Fever

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet