MCID: LTR003
MIFTS: 38

Lateral Medullary Syndrome

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Lateral Medullary Syndrome

MalaCards integrated aliases for Lateral Medullary Syndrome:

Name: Lateral Medullary Syndrome 12 49 50 41 14 69
Posterior Inferior Cerebellar Artery Syndrome 12 49
Vertebral Artery Syndrome 49 69
Wallenberg's Syndrome 49 50
Wallenberg Syndrome 12 49
Pica Syndrome 49

Classifications:



External Ids:

Disease Ontology 12 DOID:3522
ICD10 32 G46.3
MeSH 41 D014854
NCIt 46 C84807
SNOMED-CT 64 195193009 78569004

Summaries for Lateral Medullary Syndrome

NINDS : 50 Wallenberg’s syndrome is a neurological condition caused by a stroke in the vertebral or posterior inferior cerebellar artery of the brain stem. Symptoms include difficulties with swallowing, hoarseness, dizziness, nausea and vomiting, rapid involuntary movements of the eyes (nystagmus), and problems with balance and gait coordination. Some individuals will experience a lack of pain and temperature sensation on only one side of the face, or a pattern of symptoms on opposite sides of the body – such as paralysis or numbness in the right side of the face, with weak or numb limbs on the left side. Uncontrollable hiccups may also occur, and some individuals will lose their sense of taste on one side of the tongue, while preserving taste sensations on the other side. Some people with Wallenberg’s syndrome report that the world seems to be tilted in an unsettling way, which makes it difficult to keep their balance when they walk.

MalaCards based summary : Lateral Medullary Syndrome, also known as posterior inferior cerebellar artery syndrome, is related to vertebral artery insufficiency and parapharyngeal meningioma. An important gene associated with Lateral Medullary Syndrome is FGB (Fibrinogen Beta Chain), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. Affiliated tissues include brain, eye and tongue.

NIH Rare Diseases : 49 Wallenberg syndromeis a condition that affects the nervous system. Signs and symptoms may include swallowing difficulties, dizziness, hoarseness, nausea and vomiting, nystagmus, and problems with balance. Some people have uncontrollable hiccups, loss of pain and temperature sensation on one side of the face, and/or weakness or numbness on one side of the body. Wallenberg syndrome is often caused by a stroke in the brain stem. Treatment addresses each symptom and may include a feeding tube for swallowing problems, speech and/or swallowing therapy, and medication for pain. While some people's symptoms may improve within weeks or months, others may have long-term neurological problems. Last updated: 5/22/2017

Wikipedia : 72 Lateral medullary syndrome is a neurological disorder causing a range of symptoms due to ischemia in the... more...

Related Diseases for Lateral Medullary Syndrome

Diseases related to Lateral Medullary Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 vertebral artery insufficiency 11.2
2 parapharyngeal meningioma 10.6 CR1 CR2
3 interdigitating dendritic cell sarcoma 10.5 CR1 CR2
4 langerhans cell sarcoma 10.5 CR1 CR2
5 immunodeficiency, common variable, 2 10.5 CD19 CR2
6 lobomycosis 10.5 CD19 CR2
7 histiocytic and dendritic cell cancer 10.5 CR1 CR2
8 t-cell/histiocyte rich large b cell lymphoma 10.5 CR1 CR2
9 central nervous system leukemia 10.5 CD19 CR1
10 castleman disease 10.5 CR1 CR2
11 bladder lymphoma 10.5 CD19 CR2
12 colon lymphoma 10.4 CD19 CD22
13 fungal esophagitis 10.4 ATP12A ATP4A
14 bladder calculus 10.4 ATP12A ATP4A
15 gastrointestinal neuroendocrine benign tumor 10.4 ATP12A ATP4A
16 gastric neuroendocrine neoplasm 10.4 ATP12A ATP4A
17 neonatal candidiasis 10.4 ATP12A ATP4A
18 photoallergic dermatitis 10.4 ATP12A ATP4A
19 squamous papillomatosis 10.4 ATP12A ATP4A
20 acute laryngitis 10.4 ATP12A ATP4A
21 gastroduodenal crohn's disease 10.4 ATP12A ATP4A
22 reticulum cell sarcoma 10.4 CR1 CR2
23 toxic megacolon 10.4 ATP12A ATP4A
24 aspiration pneumonitis 10.4 ATP12A ATP4A
25 gastric antral vascular ectasia 10.4 ATP12A ATP4A
26 esophageal candidiasis 10.4 ATP12A ATP4A
27 postsurgical hypothyroidism 10.4 ATP12A ATP4A
28 rumination disorder 10.4 ATP12A ATP4A
29 laryngeal disease 10.4 ATP12A ATP4A
30 duodenitis 10.4 ATP12A ATP4A
31 congenital disorder of deglycosylation 10.4 ATP12A ATP4A
32 bile reflux 10.4 ATP12A ATP4A
33 active peptic ulcer disease 10.4 ATP12A ATP4A
34 hyperhidrosis, gustatory 10.4 CANX KANTR
35 dyskinesia of esophagus 10.4 ATP12A ATP4A
36 ischemic neuropathy 10.4 ATP12A ATP4A
37 capillary disease 10.4 ATP12A ATP4A
38 peptic esophagitis 10.4 ATP12A ATP4A
39 duodenal disease 10.4 ATP12A ATP4A
40 lung lymphoma 10.4 CD19 CD22 CR2
41 hernia, hiatus 10.4 ATP12A ATP4A
42 esophageal atresia/tracheoesophageal fistula 10.3 ATP12A ATP4A
43 brain stem infarction 10.3 FGB MRPS22 PLG
44 laryngitis 10.3 ATP12A ATP4A
45 sphenoid sinusitis 10.3 KANTR MRPS22
46 lymphocytic colitis 10.3 ATP12A ATP4A
47 thyroid crisis 10.3 CR1 KANTR
48 chronic intestinal vascular insufficiency 10.3 ATP12A ATP4A
49 clostridium difficile colitis 10.3 ATP12A ATP4A
50 lower urinary tract calculus 10.3 ATP12A ATP4A

Graphical network of the top 20 diseases related to Lateral Medullary Syndrome:



Diseases related to Lateral Medullary Syndrome

Symptoms & Phenotypes for Lateral Medullary Syndrome

Drugs & Therapeutics for Lateral Medullary Syndrome

Search Clinical Trials , NIH Clinical Center for Lateral Medullary Syndrome

Cochrane evidence based reviews: lateral medullary syndrome

Genetic Tests for Lateral Medullary Syndrome

Anatomical Context for Lateral Medullary Syndrome

MalaCards organs/tissues related to Lateral Medullary Syndrome:

38
Brain, Eye, Tongue, Medulla Oblongata, Cortex, Skin

Publications for Lateral Medullary Syndrome

Articles related to Lateral Medullary Syndrome:

(show top 50) (show all 84)
# Title Authors Year
1
Lateral medullary syndrome following injury of the vestibular pathway to the core vestibular cortex: Diffusion tensor imaging study. ( 29217256 )
2018
2
A rare presentation of trigeminal neuralgia in lateral medullary syndrome. ( 28488638 )
2017
3
Efficacy of BoNT-A and swallowing treatment for oropharyngeal dysphagia recovery in a patient with Lateral Medullary Syndrome: a case study. ( 28264544 )
2017
4
Lateral medullary syndrome after a scorpion sting. ( 29026772 )
2017
5
Three atypical manifestations of granulomatosis with polyangiitis: lateral medullary syndrome, anterior cheek mass and melting scleritis of eye. ( 28769139 )
2017
6
Posterior inferior cerebellar artery susceptibility sign in lateral medullary syndrome. ( 28290427 )
2017
7
Neuroimaging "HINTS" of the Lateral Medullary Syndrome. ( 28471903 )
2017
8
Wallenberg's lateral medullary syndrome in an adolescent. ( 27246963 )
2016
9
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with lateral medullary syndrome: case report and literature review. ( 27461339 )
2016
10
Ipsilateral Facial Tactile Hypesthesia in a Patient with Lateral Medullary Syndrome. ( 26350694 )
2015
11
Subjective visual vertical and horizontal abnormalities in a patient with lateral medullary syndrome-a case report. ( 25745615 )
2015
12
Ipsipulsion: A forgotten sign of lateral medullary syndrome. ( 26425003 )
2015
13
Lateral medullary syndrome: a diagnostic approach illustrated through case presentation and literature review. ( 24626124 )
2014
14
Persistent hiccups (singultus) as the presenting symptom of lateral medullary syndrome. ( 25035568 )
2014
15
Hemi-seesaw nystagmus in lateral medullary syndrome. ( 23446678 )
2013
16
An unexpected Holter monitor result: multiple sinus arrests in a patient with lateral medullary syndrome. ( 23386489 )
2013
17
Variant lateral medullary syndrome in a patient presenting with inability to swallow. ( 23983892 )
2013
18
Opalski syndrome: a variant of lateral-medullary syndrome. ( 22608536 )
2013
19
Opalski's syndrome: A rare variant of lateral medullary syndrome. ( 23546377 )
2013
20
Lateral medullary syndrome: a diagnostic approach illustrated through case presentation and literature review. ( 23870801 )
2013
21
Up-down asymmetry of saccadic contrapulsion in lateral medullary syndrome. ( 22790667 )
2012
22
Lateral medullary syndrome in a boy with hereditary dysfibrinogenemia. ( 22449744 )
2012
23
Varicella zoster vasculopathy presenting as lateral medullary syndrome. ( 23070818 )
2012
24
Lateral medullary syndrome due to brain stem tuberculoma. ( 21751596 )
2011
25
Vertebral artery dissection presented as lateral medullary syndrome in a patient with migraine: a case report. ( 21210329 )
2010
26
Therapeutic role of rTMS on recovery of dysphagia in patients with lateral medullary syndrome and brainstem infarction. ( 19828479 )
2010
27
Sudden death in a case of lateral medullary syndrome. ( 19439870 )
2009
28
Lateral medullary syndrome with anti-neuronal antibodies (anti-Ta/Ma2) in primary Sjogren's syndrome. ( 19620208 )
2009
29
Lateral medullary syndrome and ipsilateral hemiplegia (Opalski syndrome) due to left vertebral artery dissection. ( 20008668 )
2009
30
Lateral medullary syndrome presenting with ataxia and bradycardia. ( 19534348 )
2009
31
Incomplete lateral medullary syndrome in a patient with Chiari malformation Type I presenting with combined trigeminal and vagal nerve dysfunction. ( 18831657 )
2008
32
Paroxysmal sneezing at the onset of lateral medullary syndrome: cause or consequence? ( 17388999 )
2007
33
Stridor: an unusual presentation of lateral medullary syndrome. ( 17367563 )
2007
34
Lateral medullary syndrome in a woman after ovulation induction. ( 17344003 )
2007
35
Skull base osteomyelitis leading to lateral medullary syndrome in a child. ( 17258480 )
2007
36
Lateral medullary syndrome caused by penetrating head injury. ( 16914313 )
2006
37
Pontomedullary sulcus infarct: a variant of lateral medullary syndrome. ( 17043294 )
2006
38
Vestibular assessment in a patient with confirmed lateral medullary syndrome. ( 16371169 )
2006
39
Thrombolysis in a case of lateral medullary syndrome: CT angiographic findings. ( 15824352 )
2005
40
An atypic herpes encephalitis with Wallenberg's lateral medullary syndrome and CD receptors deficiency. ( 15168883 )
2004
41
Wallenberg's lateral medullary syndrome: diffusion-weighted imaging findings. ( 15164784 )
2004
42
Fibromuscular dysplasia of the vertebral artery presenting with lateral medullary syndrome: a case report. ( 15666696 )
2004
43
Rapidly progressive fatal respiratory failure (Ondine's curse) in the lateral medullary syndrome. ( 17903948 )
2004
44
Relapsing polychondritis with involvement of posterior inferior cerebellar artery causing acute lateral medullary syndrome. ( 17041437 )
2003
45
Lateral medullary syndrome after prone position for general surgery. ( 12401643 )
2002
46
Wallenberg's lateral medullary syndrome. ( 12415087 )
2002
47
Dysphagia in a patient with lateral medullary syndrome: insight into the central control of swallowing. ( 11487551 )
2001
48
Loss of ability to sneeze in lateral medullary syndrome. ( 10668732 )
2000
49
Restricted dissociated sensory loss in a patient with a lateral medullary syndrome: A clinical-MRI study. ( 11108773 )
2000
50
CT study of closure of the hemipharynx with head rotation in a case of lateral medullary syndrome. ( 10594254 )
2000

Variations for Lateral Medullary Syndrome

Expression for Lateral Medullary Syndrome

Search GEO for disease gene expression data for Lateral Medullary Syndrome.

Pathways for Lateral Medullary Syndrome

GO Terms for Lateral Medullary Syndrome

Cellular components related to Lateral Medullary Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 APOH ATP4A FGB LEP PF4 PLG
2 extracellular exosome GO:0070062 9.61 APOH CANX CD19 CD22 CR1 CR2
3 platelet alpha granule lumen GO:0031093 8.8 FGB PF4 PLG

Biological processes related to Lateral Medullary Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of complement activation GO:0030449 9.58 CD19 CR1 CR2
2 fibrinolysis GO:0042730 9.43 FGB PLG
3 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.37 ATP12A ATP4A
4 plasminogen activation GO:0031639 9.32 APOH FGB
5 complement receptor mediated signaling pathway GO:0002430 9.26 CR1 CR2
6 cellular response to leptin stimulus GO:0044320 9.16 FGB LEP
7 negative regulation of fibrinolysis GO:0051918 8.96 APOH PLG
8 platelet degranulation GO:0002576 8.92 APOH FGB PF4 PLG

Molecular functions related to Lateral Medullary Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.56 FGB LEP PLG PRTN3
2 apolipoprotein binding GO:0034185 9.16 CANX PLG
3 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
4 hydrogen:potassium-exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Lateral Medullary Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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